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Aliases for CTXN2 Gene

Aliases for CTXN2 Gene

  • Cortexin 2 2 3 5
  • Cortexin-2 3

External Ids for CTXN2 Gene

Previous GeneCards Identifiers for CTXN2 Gene

  • GC15U900443
  • GC15P048483
  • GC15P025316

Summaries for CTXN2 Gene

GeneCards Summary for CTXN2 Gene

CTXN2 (Cortexin 2) is a Protein Coding gene. An important paralog of this gene is CTXN3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTXN2 Gene

Genomics for CTXN2 Gene

Regulatory Elements for CTXN2 Gene

Enhancers for CTXN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F048266 0.3 FANTOM5 9.9 +88.1 88102 0.0 HMBOX1 SLC12A1 SLC24A5 CTXN2 PIR60543 ENSG00000202542 GC15M048328
GH15F048176 0.5 ENCODE 0.8 -0.5 -485 2.4 SIN3A ZNF48 BRCA1 SCRT2 RCOR1 YY2 CBFB MXD4 JUNB REST CTXN2 GC15P048147
GH15F048149 0.4 ENCODE 0.3 -28.2 -28184 1.9 JUND JUN MAFK GC15P048147 CTXN2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CTXN2 on UCSC Golden Path with GeneCards custom track

Promoters for CTXN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CTXN2 Gene

48,178,355 bp from pter
48,203,756 bp from pter
25,402 bases
Plus strand

Genomic View for CTXN2 Gene

Genes around CTXN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTXN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTXN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTXN2 Gene

Proteins for CTXN2 Gene

  • Protein details for CTXN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for CTXN2 Gene

    81 amino acids
    Molecular mass:
    8980 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTXN2 Gene

Post-translational modifications for CTXN2 Gene

No Post-translational modifications

Other Protein References for CTXN2 Gene

No data available for DME Specific Peptides for CTXN2 Gene

Domains & Families for CTXN2 Gene

Protein Domains for CTXN2 Gene


Suggested Antigen Peptide Sequences for CTXN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cortexin family.
  • Belongs to the cortexin family.
genes like me logo Genes that share domains with CTXN2: view

No data available for Gene Families for CTXN2 Gene

Function for CTXN2 Gene

Phenotypes for CTXN2 Gene

GenomeRNAi human phenotypes for CTXN2:
genes like me logo Genes that share phenotypes with CTXN2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTXN2 Gene

Localization for CTXN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTXN2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CTXN2 Gene COMPARTMENTS Subcellular localization image for CTXN2 gene
Compartment Confidence
cytosol 2
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0031224 intrinsic component of membrane IEA --
genes like me logo Genes that share ontologies with CTXN2: view

Pathways & Interactions for CTXN2 Gene

SuperPathways for CTXN2 Gene

No Data Available

Interacting Proteins for CTXN2 Gene

Gene Ontology (GO) - Biological Process for CTXN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for CTXN2 Gene

Transcripts for CTXN2 Gene

mRNA/cDNA for CTXN2 Gene

(5) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTXN2 Gene

Cortexin 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTXN2 Gene

No ASD Table

Relevant External Links for CTXN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTXN2 Gene

mRNA expression in normal human tissues for CTXN2 Gene

mRNA differential expression in normal tissues according to GTEx for CTXN2 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.1), Brain - Frontal Cortex (BA9) (x5.6), Brain - Cortex (x5.3), and Brain - Anterior cingulate cortex (BA24) (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of CTXN2 Gene:


SOURCE GeneReport for Unigene cluster for CTXN2 Gene:

genes like me logo Genes that share expression patterns with CTXN2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CTXN2 Gene

Orthologs for CTXN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTXN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTXN2 34 35
  • 100 (n)
(Monodelphis domestica)
Mammalia CTXN2 35
  • 98 (a)
(Canis familiaris)
Mammalia CTXN2 34 35
  • 96.71 (n)
(Bos Taurus)
Mammalia CTXN2 34 35
  • 96.3 (n)
(Mus musculus)
Mammalia Ctxn2 34 16 35
  • 86.83 (n)
(Rattus norvegicus)
Mammalia Ctxn2 34
  • 83.54 (n)
(Ornithorhynchus anatinus)
Mammalia CTXN2 35
  • 79 (a)
(Gallus gallus)
Aves LOC100859495 34
  • 83.95 (n)
(Danio rerio)
Actinopterygii ctxn2 34
  • 65 (n)
Species where no ortholog for CTXN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTXN2 Gene

Gene Tree for CTXN2 (if available)
Gene Tree for CTXN2 (if available)

Paralogs for CTXN2 Gene

Paralogs for CTXN2 Gene

(2) SIMAP similar genes for CTXN2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTXN2: view

Variants for CTXN2 Gene

Sequence variations from dbSNP and Humsavar for CTXN2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11070627 -- 48,179,327(+) CTCAA(A/T)TAACA intron-variant, upstream-variant-2KB
rs11070628 -- 48,179,418(+) ACACA(C/G/T)ACACA intron-variant, upstream-variant-2KB
rs111345894 -- 48,184,930(+) AAACT(G/T)TGGCA intron-variant
rs111375055 -- 48,180,394(+) TTGAT(C/T)TTTCC intron-variant, upstream-variant-2KB
rs111924919 -- 48,179,417(+) CACAC(-/AT)ACACA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CTXN2 Gene

Variant ID Type Subtype PubMed ID
esv3636411 CNV loss 21293372

Variation tolerance for CTXN2 Gene

Gene Damage Index Score: 1.33; 26.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTXN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTXN2 Gene

Disorders for CTXN2 Gene

Relevant External Links for CTXN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CTXN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTXN2 Gene

Publications for CTXN2 Gene

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 3 4 64
  2. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for CTXN2 Gene

Sources for CTXN2 Gene

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