CTXN2 Gene
protein-coding GIFtS: 34
GCID: GC15P048483
|
|
cortexin 2
| |
Aliases
for CTXN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cortexin 21 2 | | Cortexin-21 |
Export aliases for CTXN2 gene to outside databasesPrevious GC identifers: GC15U900443 GC15P025316 |
Summaries
for CTXN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CTXN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CTXN2 gene promoter:
MEF-2A POU2F1 ATF-2 Olf-1 FOXD3 aMEF-2 Nkx5-1 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for CTXN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTXN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q21.1 Ensembl cytogenetic band: 15q21.1 HGNC chromosome: 15CTXN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P048483: view genomic region
(about GC identifiers)
Start:
|
48,483,736 bp from pter |
End:
|
48,495,953 bp from pter |
Size:
|
12,218 bases |
Orientation:
|
plus strand |
|
Proteins
for CTXN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CTXN2_HUMAN, P0C2S0 (See
protein sequence)Recommended Name: Cortexin-2 Size: 81 amino acids; 8980 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for CTXN2: NX_P0C2S0
CTXN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001139140.1
ENSEMBL proteins: ENSP00000406145 ENSP00000445900
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
CTXN2 for ontologies About GeneDecksing
CTXN2 Antibody Products:
Assay Products for CTXN2: |
Protein
Domains /
Families
for CTXN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CTXN2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P0C2S0ProtoNet protein and cluster: P0C2S0 UniProtKB/Swiss-Prot: CTXN2_HUMAN, P0C2S0Similarity: Belongs to the cortexin family |
Function
for CTXN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTXN2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTXN2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CTXN2 (NM_001145668) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTXN2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CTXN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTXN2 |
1 GenomeRNAi human phenotype for CTXN2:
|
Pathways & Interactions
for CTXN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTXN2
|
Drugs & Compounds
for CTXN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CTXN2
Search CenterWatch for drugs/clinical trials and news about CTXN2
|
Transcripts
for CTXN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CTXN2 gene: NM_001145668.1 Unigene Cluster for CTXN2: Cortexin 2 Hs.721408 [show with all ESTs]Unigene Representative Sequence: BX5377722 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000417307(uc001zwm.1) ENST00000541248
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTXN2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTXN2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CTXN2 (NM_001145668) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTXN2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CTXN2 |
Additional cDNA sequence: BX537772.1 2 DOTS entries: DT.99971600 DT.70105391
GeneLoc Exon Structure
|
Expression
for CTXN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CTXN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTACTGCTC
About this image
See CTXN2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.721408
SABiosciences Custom PCR Arrays for CTXN2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTXN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CTXN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTXN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTXN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTXN2 |
Orthologs
for CTXN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CTXN2 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for CTXN2 (if available)
TreeFam Gene Tree for CTXN2 (if available) |
Paralogs
for CTXN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CTXN2 gene
- CTXN32 CTXN12
2 SIMAP similar genes for CTXN2 using alignment to 1 protein entry: CTXN2_HUMAN:CTXN3 CTXN1
CTXN2 for paralogs About GeneDecksing
|
Genomic Variants
for CTXN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CTXN2 (48483736 - 48495953 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CTXN2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTXN2 |
|
Disorders
/ Diseases
for CTXN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CTXN2 for disorders About GeneDecksing
3  diseases for CTXN2: About MalaCardsloeys-dietz syndrome progressive multifocal leukoencephalopathy cystoid macular edema
2 diseases from the University of Copenhagen DISEASES database for CTXN2:Loeys-Dietz syndrome Cystoid macular edema Export disorders for CTXN2 gene to outside databases
|
Publications
for CTXN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CTXN2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CTXN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (2006)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for CTXN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CTXN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CTXN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CTXN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CTXN2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CTXN2 gene:
Search GeneIP for patents involving CTXN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CTXN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CTXN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTXN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTXN2 | | | OriGene Protein Over-expression Lysate for CTXN2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CTXN2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTXN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTXN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CTXN2 | | OriGene Custom Protein Services for CTXN2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTXN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTXN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTXN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTXN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTXN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTXN2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CTXN2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CTXN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTXN2 |
|  |  |  | | | | Search ThermoFisher Antibodies for CTXN2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CTXN2 |
|
|
|
|
