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Aliases for CTXN1 Gene

Aliases for CTXN1 Gene

  • Cortexin 1 2 3
  • CTXN 3 4 6
  • Cortexin-1 3

External Ids for CTXN1 Gene

Previous GeneCards Identifiers for CTXN1 Gene

  • GC19U900430
  • GC19M007896
  • GC19M007898
  • GC19M007989
  • GC19M007660

Summaries for CTXN1 Gene

GeneCards Summary for CTXN1 Gene

CTXN1 (Cortexin 1) is a Protein Coding gene. Diseases associated with CTXN1 include corneal edema. An important paralog of this gene is CTXN2.

UniProtKB/Swiss-Prot for CTXN1 Gene

  • May mediate extracellular or intracellular signaling of cortical neurons during forebrain development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTXN1 Gene

Genomics for CTXN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTXN1 Gene

7,924,485 bp from pter
7,926,166 bp from pter
1,682 bases
Minus strand

Genomic View for CTXN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTXN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTXN1 Gene

Proteins for CTXN1 Gene

  • Protein details for CTXN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CTXN1 Gene

    82 amino acids
    Molecular mass:
    9045 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTXN1 Gene

Proteomics data for CTXN1 Gene at MOPED

Post-translational modifications for CTXN1 Gene

  • Ubiquitination at Lys69
  • Modification sites at PhosphoSitePlus

Other Protein References for CTXN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTXN1 Gene

Domains for CTXN1 Gene

Protein Domains for CTXN1 Gene


Suggested Antigen Peptide Sequences for CTXN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cortexin family.
  • Belongs to the cortexin family.
genes like me logo Genes that share domains with CTXN1: view

No data available for Gene Families for CTXN1 Gene

Function for CTXN1 Gene

Molecular function for CTXN1 Gene

UniProtKB/Swiss-Prot Function:
May mediate extracellular or intracellular signaling of cortical neurons during forebrain development.

Phenotypes for CTXN1 Gene

GenomeRNAi human phenotypes for CTXN1:
genes like me logo Genes that share phenotypes with CTXN1: view

Animal Model Products

miRNA for CTXN1 Gene

miRTarBase miRNAs that target CTXN1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTXN1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CTXN1 Gene

Localization for CTXN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTXN1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CTXN1 Gene COMPARTMENTS Subcellular localization image for CTXN1 gene
Compartment Confidence
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0031224 intrinsic component of membrane --
genes like me logo Genes that share ontologies with CTXN1: view

Pathways for CTXN1 Gene

SuperPathways for CTXN1 Gene

No Data Available

Interacting Proteins for CTXN1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000313226 for CTXN1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CTXN1 Gene


No data available for Pathways by source for CTXN1 Gene

Drugs for CTXN1 Gene

(1) Novoseek inferred chemical compound relationships for CTXN1 Gene

Compound -log(P) Hits PubMed IDs
epithalamin 85.7 4
genes like me logo Genes that share compounds with CTXN1: view

Transcripts for CTXN1 Gene

mRNA/cDNA for CTXN1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(355) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTXN1 Gene

Cortexin 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTXN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTXN1 Gene

No ASD Table

Relevant External Links for CTXN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTXN1 Gene

mRNA expression in normal human tissues for CTXN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTXN1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (7.6), Brain - Putamen (basal ganglia) (7.4), Brain - Caudate (basal ganglia) (6.6), Brain - Hippocampus (4.7), and Brain - Amygdala (4.2).

Protein differential expression in normal tissues for CTXN1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CTXN1 Gene

SOURCE GeneReport for Unigene cluster for CTXN1 Gene Hs.657978

genes like me logo Genes that share expressions with CTXN1: view

Expression partners for CTXN1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CTXN1 Gene

Orthologs for CTXN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTXN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTXN1 35
  • 94.72 (n)
  • 100 (a)
CTXN1 36
  • 96 (a)
(Canis familiaris)
Mammalia CTXN1 35
  • 96.75 (n)
  • 98.78 (a)
CTXN1 36
  • 99 (a)
(Mus musculus)
Mammalia Ctxn1 35
  • 93.09 (n)
  • 96.34 (a)
Ctxn1 16
Ctxn1 36
  • 96 (a)
(Pan troglodytes)
Mammalia CTXN1 35
  • 100 (n)
  • 100 (a)
CTXN1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ctxn1 35
  • 91.87 (n)
  • 97.56 (a)
(Ornithorhynchus anatinus)
Mammalia CTXN1 36
  • 78 (a)
(Gallus gallus)
Aves CTXN1 36
  • 70 (a)
(Danio rerio)
Actinopterygii CTXN1 (1 of 2) 36
  • 54 (a)
CTXN1 (2 of 2) 36
  • 61 (a)
Species with no ortholog for CTXN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTXN1 Gene

Gene Tree for CTXN1 (if available)
Gene Tree for CTXN1 (if available)

Paralogs for CTXN1 Gene

Paralogs for CTXN1 Gene

(2) SIMAP similar genes for CTXN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTXN1: view

Variants for CTXN1 Gene

Sequence variations from dbSNP and Humsavar for CTXN1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs35756104 -- 7,924,215(+) ATCAG(-/C)CCCCC downstream-variant-500B
rs79360620 -- 7,925,487(+) CGGGG(G/T)CCCCG missense, reference
rs79409642 -- 7,924,981(+) AGGGG(A/G)CGGTG utr-variant-3-prime
rs111971063 -- 7,926,050(+) CTCTC(A/C)CCGGC utr-variant-5-prime
rs370706588 -- 7,925,479(+) GCGCC(A/C)ACCGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CTXN1 Gene

Variant ID Type Subtype PubMed ID
dgv3715n71 CNV Loss 21882294
nsv833733 CNV Gain 17160897
dgv3716n71 CNV Loss 21882294
nsv910989 CNV Loss 21882294
nsv910990 CNV Loss 21882294
nsv910993 CNV Loss 21882294

Relevant External Links for CTXN1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTXN1 Gene

Disorders for CTXN1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CTXN1 Gene in MalaCards »

(1) Disease for CTXN1 Gene

(1) University of Copenhagen DISEASES for CTXN1 Gene

genes like me logo Genes that share disorders with CTXN1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for CTXN1 Gene

Publications for CTXN1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  3. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  4. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3
  5. Purification and mechanism of action of "cortexin," a novel antihypertensive protein hormone from kidney and its role in essential hypertension in men. (PMID: 20409952) Chakraborty S. … Sinha A.K. (J Am Soc Hypertens 2009) 23

Products for CTXN1 Gene

Sources for CTXN1 Gene

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