CTXN1 Gene
protein-coding GIFtS : 43
GCID: GC19 M007989
cortexin 1
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Aliasesfor CTXN1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Cortexin 1 1 2 CTXN2 3 5 FLJ259681 Cortexin-11
Export aliases for CTXN1 gene to outside databases Previous GC identifers: GC19U900430 GC19M007896 GC19M007898 GC19M007660
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Summariesfor CTXN1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: CTXN1_HUMAN, P60606 Function : May mediate extracellular or intracellular signaling of cortical neurons during forebrain development (Bysimilarity)
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Genomic Viewsfor CTXN1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_077812.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CTXN1 gene promoter: Pax-5 NRSF form 1 Lmo2 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) STAT5A NRSF form 2 MEF-2A SRY aMEF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for CTXN1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CTXN1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2 CTXN1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19M007989: view genomic region
(about GC identifiers )
Start:
7,989,381 bp from pter
End:
7,991,051 bp from pter
Size:
1,671 bases
Orientation:
minus strand
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Proteinsfor CTXN1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CTXN1_HUMAN, P60606 (See
protein sequence )Recommended Name: Cortexin-1 Size : 82 amino acids; 9045 Da
Subcellular location : Membrane; Single-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for CTXN1: NX_P60606 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P60606 CTXN1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_996664.1 ENSEMBL proteins: ENSP00000313226 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
CTXN1 for ontologies About GeneDecksing CTXN1 Antibody Products: Assay Products for CTXN1:
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Protein
Domains / Familiesfor CTXN1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CTXN1 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry P60606 ProtoNet protein and cluster: P60606
UniProtKB/Swiss-Prot: CTXN1_HUMAN, P60606 Similarity : Belongs to the cortexin family
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Functionfor CTXN1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CTXN1_HUMAN, P60606 Function : May mediate extracellular or intracellular signaling of cortical neurons during forebrain development (Bysimilarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CTXN1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CTXN1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CTXN1 (NM_206833 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTXN1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CTXN1
1 GenomeRNAi human phenotype for CTXN1 :
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Pathways & Interactionsfor CTXN1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTXN1
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Drugs & Compoundsfor CTXN1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
CTXN1 for compounds About GeneDecksing Browse Tocris compounds for CTXN1 1 Novoseek chemical compound relationship for CTXN1 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
epithalamin
85.7
4
10970020 (2), 9490497 (2)
Search CenterWatch for drugs/clinical trials and news about CTXN1
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Transcriptsfor CTXN1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CTXN1 gene: NM_206833.3 Unigene Cluster for CTXN1:
Cortexin 1 Hs.657978 [show with all ESTs ] Unigene Representative Sequence: BQ278750 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000318978 (uc002miy.4 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CTXN1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CTXN1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CTXN1 (NM_206833 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTXN1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CTXN1
Additional cDNA sequence: AK098834.1 BC024148.2 BC040420.2 BC062702.1
4 DOTS entries : DT.70103774 DT.121452012
DT.91651067 DT.310231 24/355 AceView cDNA sequences (see all 355 ):
BM724653 BX364558 AI589670 CR595021 AI923270 BM756736 CR597878 BP351709 BM742224 CA489444 BM796411 AK098834 BM069486 BM750692 CB152340 BM770335 T28125 AA477833 NM_006351 F27317 BQ072969 BP373084 BQ649769 CR597337 GeneLoc Exon Structure
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Expression for CTXN1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CTXN1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image CTXN1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Brain Cerebral Cortex Brain Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See CTXN1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CTXN1 SOURCE GeneReport for Unigene cluster: Hs.657978 SABiosciences Custom PCR Arrays for CTXN1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CTXN1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CTXN1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CTXN1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CTXN1
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Orthologsfor CTXN1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for CTXN1 gene from 2/8 species (see all 8 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
CTXN11
cortexin 1
72.36(n) 73.17(a)
 
420051 XM_429729.2 XP_429729.3
zebrafish (Danio rerio)
Actinopterygii
CU693374.26
--
54(a)
1 ↔ 1
2(56644028-56644297)
ENSEMBL Gene Tree for CTXN1 (if available)TreeFam Gene Tree for CTXN1 (if available)
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Paralogsfor CTXN1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CTXN1 gene CTXN2 2 CTXN3 2 2 SIMAP similar genes for CTXN1 using alignment to 1 protein entry: CTXN1_HUMAN :CTXN2 CTXN3
CTXN1 for paralogs About GeneDecksing
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Genomic Variantsfor CTXN1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 19 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CTXN1 (7989381 - 7991051 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CTXN1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CTXN1
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Disorders
/ Diseasesfor CTXN1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CTXN1 for disorders About GeneDecksing
OMIM gene information: 600135
OMIM disorders : --5 diseases for CTXN1 : About MalaCards corneal edema hypertension cerebritis tuberculosis neuronitis 1 disease from the University of Copenhagen DISEASES database for CTXN1 :Corneal edema Export disorders for CTXN1 gene to outside databases
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Publicationsfor CTXN1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CTXN1 gene, integrated from 9 sources (see all 25 ): (articles sorted by number of sources associating them with CTXN1) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Identification of cortexin: a novel, neuron-specific, 82-residue membrane protein enriched in rodent cerebral cortex. (PubMed id 8336151) 1 Coulter P.M....Watson J.B. (1993) [Cortexin effectiveness in circulatory encephalopathy ] (PubMed id 10356917) 9 Khavinson V.K.h....ZakutskiA- N.G. (1999) Purification and mechanism of action of 'cortexi n,' a novel antihypertensive protein hormone from kidney and its role in e ssential hypertension in men. (PubMed id 20409952) 9 Chakraborty S....Sinha A.K. (2009) [Influence of cortexin on memory and attention] (PubMed id 15537099) 9 Tsyganov V.N. and BogoslovskiA- M.M. (2004) Cortexin and combination of nitrite with cortexin dec rease swelling and destruction of cerebellar neurons in hemorrhagic stroke. (PubMed id 19650315) 9 Reutov V.P....Chailakhyan L.M. (2009) [Comparative analysis of efficacy of certain neuroprotectors in ischemic stroke] (PubMed id 18193579) 9 Skorokhodov A.P....Sedova A.A. (2006) [Use of cortexin electrophoresis in the prophylaxis o f cerebral strokes] (PubMed id 15154345) 9 Markin S.P....Borisov V.A. (2004)
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External Searches for CTXN1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CTXN1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CTXN1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CTXN1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CTXN1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CTXN1 gene: Search GeneIP for patents involving CTXN1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CTXN1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CTXN1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CTXN1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CTXN1 OriGene Protein Over-expression Lysate for CTXN1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CTXN1 OriGene 3'-UTR Clone for CTXN1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CTXN1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CTXN1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CTXN1 OriGene Custom Protein Services for CTXN1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTXN1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CTXN1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CTXN1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CTXN1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CTXN1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CTXN1
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CTXN1 Proteins, Antibodies, CLIAs, and ELISAs
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CTXN1
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