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Aliases for CTXN1 Gene

Aliases for CTXN1 Gene

  • Cortexin 1 2 3
  • CTXN 3 4 6
  • Cortexin-1 3

External Ids for CTXN1 Gene

Summaries for CTXN1 Gene

GeneCards Summary for CTXN1 Gene

CTXN1 (Cortexin 1) is a Protein Coding gene. Diseases associated with CTXN1 include corneal edema. An important paralog of this gene is CTXN2.

UniProtKB/Swiss-Prot for CTXN1 Gene

  • May mediate extracellular or intracellular signaling of cortical neurons during forebrain development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTXN1 Gene

Genomics for CTXN1 Gene

Genomic Location for CTXN1 Gene

Start:
7,924,485 bp from pter
End:
7,926,166 bp from pter
Size:
1,682 bases
Orientation:
Minus strand

Genomic View for CTXN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTXN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTXN1 Gene

Proteins for CTXN1 Gene

  • Protein details for CTXN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60606-CTXN1_HUMAN
    Recommended name:
    Cortexin-1
    Protein Accession:
    P60606
    Secondary Accessions:

    Protein attributes for CTXN1 Gene

    Size:
    82 amino acids
    Molecular mass:
    9045 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTXN1 Gene

Proteomics data for CTXN1 Gene at MOPED

Post-translational modifications for CTXN1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys69

Other Protein References for CTXN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTXN1 Gene

Domains for CTXN1 Gene

Protein Domains for CTXN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CTXN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60606

UniProtKB/Swiss-Prot:

CTXN1_HUMAN
Family:
  • Belongs to the cortexin family.:
    • P60606
genes like me logo Genes that share domains with CTXN1: view

No data available for Gene Families for CTXN1 Gene

Function for CTXN1 Gene

Molecular function for CTXN1 Gene

UniProtKB/Swiss-Prot Function: May mediate extracellular or intracellular signaling of cortical neurons during forebrain development.

Phenotypes for CTXN1 Gene

GenomeRNAi human phenotypes for CTXN1:
genes like me logo Genes that share phenotypes with CTXN1: view

miRNA for CTXN1 Gene

miRTarBase miRNAs that target CTXN1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CTXN1 Gene

Localization for CTXN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTXN1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTXN1 Gene COMPARTMENTS Subcellular localization image for CTXN1 gene
Compartment Confidence
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0031224 intrinsic component of membrane --
genes like me logo Genes that share ontologies with CTXN1: view

Pathways for CTXN1 Gene

SuperPathways for CTXN1 Gene

No Data Available

Interacting Proteins for CTXN1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000313226%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000313226 for CTXN1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for CTXN1 Gene

None

No data available for Pathways by source for CTXN1 Gene

Compounds for CTXN1 Gene

(1) Novoseek inferred chemical compound relationships for CTXN1 Gene

Compound -log(P) Hits PubMed IDs
epithalamin 85.7 4
genes like me logo Genes that share compounds with CTXN1: view

Transcripts for CTXN1 Gene

mRNA/cDNA for CTXN1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(355) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTXN1 Gene

Cortexin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTXN1 Gene

No ASD Table

Relevant External Links for CTXN1 Gene

GeneLoc Exon Structure for
CTXN1
ECgene alternative splicing isoforms for
CTXN1

Expression for CTXN1 Gene

mRNA expression in normal human tissues for CTXN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTXN1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (7.6), Brain - Putamen (basal ganglia) (7.4), Brain - Caudate (basal ganglia) (6.6), Brain - Hippocampus (4.7), and Brain - Amygdala (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CTXN1 Gene

SOURCE GeneReport for Unigene cluster for CTXN1 Gene Hs.657978

genes like me logo Genes that share expressions with CTXN1: view

No data available for mRNA Expression by UniProt/SwissProt for CTXN1 Gene

Orthologs for CTXN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTXN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTXN1 35
  • 100 (n)
  • 100 (a)
CTXN1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTXN1 35
  • 94.72 (n)
  • 100 (a)
CTXN1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTXN1 35
  • 96.75 (n)
  • 98.78 (a)
CTXN1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctxn1 35
  • 93.09 (n)
  • 96.34 (a)
Ctxn1 16
Ctxn1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTXN1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctxn1 35
  • 91.87 (n)
  • 97.56 (a)
chicken
(Gallus gallus)
Aves CTXN1 36
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CTXN1 (1 of 2) 36
  • 54 (a)
OneToMany
CTXN1 (2 of 2) 36
  • 61 (a)
OneToMany
Species with no ortholog for CTXN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTXN1 Gene

ENSEMBL:
Gene Tree for CTXN1 (if available)
TreeFam:
Gene Tree for CTXN1 (if available)

Paralogs for CTXN1 Gene

Paralogs for CTXN1 Gene

Selected SIMAP similar genes for CTXN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTXN1: view

Variants for CTXN1 Gene

Sequence variations from dbSNP and Humsavar for CTXN1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs35756104 -- 7,924,215(+) ATCAG(-/C)CCCCC downstream-variant-500B
rs79360620 -- 7,925,487(+) CGGGG(G/T)CCCCG missense, reference
rs79409642 -- 7,924,981(+) AGGGG(A/G)CGGTG utr-variant-3-prime
rs111971063 -- 7,926,050(+) CTCTC(A/C)CCGGC utr-variant-5-prime
rs112116703 -- 7,925,937(+) CTCCC(A/C)CACCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTXN1 Gene

Variant ID Type Subtype PubMed ID
dgv3715n71 CNV Loss 21882294
nsv833733 CNV Gain 17160897
dgv3716n71 CNV Loss 21882294
nsv910989 CNV Loss 21882294
nsv910990 CNV Loss 21882294
nsv910993 CNV Loss 21882294

Relevant External Links for CTXN1 Gene

HapMap Linkage Disequilibrium report
CTXN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTXN1 Gene

Disorders for CTXN1 Gene

(1) MalaCards Diseases for CTXN1 Gene

Search for CTXN1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CTXN1 Gene

genes like me logo Genes that share disorders with CTXN1: view

No data available for UniProtKB/Swiss-Prot for CTXN1 Gene

Publications for CTXN1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  3. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3
  4. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3
  5. [The effect of brain peptides on nerve tissue cells in vitro]. (PMID: 9490497) Khavinson V.K.h. … Okulov V.B. (Tsitologiia 1997) 23

Products for CTXN1 Gene

Sources for CTXN1 Gene

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