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Aliases for CTXN1 Gene

Aliases for CTXN1 Gene

  • Cortexin 1 2 3 5
  • CTXN 3 4
  • Cortexin-1 3

External Ids for CTXN1 Gene

Previous GeneCards Identifiers for CTXN1 Gene

  • GC19U900430
  • GC19M007896
  • GC19M007898
  • GC19M007989
  • GC19M007660

Summaries for CTXN1 Gene

GeneCards Summary for CTXN1 Gene

CTXN1 (Cortexin 1) is a Protein Coding gene. An important paralog of this gene is CTXN3.

UniProtKB/Swiss-Prot for CTXN1 Gene

  • May mediate extracellular or intracellular signaling of cortical neurons during forebrain development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTXN1 Gene

Genomics for CTXN1 Gene

Regulatory Elements for CTXN1 Gene

Enhancers for CTXN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F007896 0.9 ENCODE 12.3 +28.7 28684 1.1 ARID4B RARA YY1 ZNF121 CREM EGR2 CEBPB KAT8 TGIF2 SSRP1 PRR36 CTXN1 LRRC8E GC19M007891 GC19M007902
GH19F007894 0.6 ENCODE 11.7 +31.3 31267 1.5 ZNF687 RFX1 DDX20 DPF2 TFDP1 RAD51 GLIS2 KLF9 CTXN1 GC19M007891 GC19M007902
GH19F007842 0.8 FANTOM5 1.3 +83.4 83427 0.5 SCRT1 SUZ12 INSM2 ZNF76 PLRG1 MNT ZNF645 ZNF121 ZNF157 POLR2A LYPLA2P2 RPL21P129 MBD3L3 MBD3L5 ENSG00000261866 FLJ25758 LINC01862 ELAVL1 LRRC8E EVI5L
GH19F007926 1.2 Ensembl ENCODE 0.8 -2.4 -2413 5.0 YY1 ZNF121 GLIS2 FOS ZNF263 SP3 TBX21 RFX3 GLIS1 MYNN TIMM44 ENSG00000269139 LOC105372266 CTXN1
GH19F007941 1.1 ENCODE 0.3 -17.2 -17247 3.0 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TIMM44 ELAVL1 HNRNPM ZNF558 CTXN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CTXN1 on UCSC Golden Path with GeneCards custom track

Promoters for CTXN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000342947 466 1401 ATF1 CREB3L1 SIN3A ARID4B ZNF48 SLC30A9 GLIS2 ZNF143 ZNF263 SP3

Genomic Location for CTXN1 Gene

Chromosome:
19
Start:
7,924,485 bp from pter
End:
7,926,166 bp from pter
Size:
1,682 bases
Orientation:
Minus strand

Genomic View for CTXN1 Gene

Genes around CTXN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTXN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTXN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTXN1 Gene

Proteins for CTXN1 Gene

  • Protein details for CTXN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60606-CTXN1_HUMAN
    Recommended name:
    Cortexin-1
    Protein Accession:
    P60606

    Protein attributes for CTXN1 Gene

    Size:
    82 amino acids
    Molecular mass:
    9045 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTXN1 Gene

Post-translational modifications for CTXN1 Gene

  • Ubiquitination at Lys 69
  • Modification sites at PhosphoSitePlus

Other Protein References for CTXN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTXN1 Gene

Domains & Families for CTXN1 Gene

Protein Domains for CTXN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CTXN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60606

UniProtKB/Swiss-Prot:

CTXN1_HUMAN :
  • Belongs to the cortexin family.
Family:
  • Belongs to the cortexin family.
genes like me logo Genes that share domains with CTXN1: view

No data available for Gene Families for CTXN1 Gene

Function for CTXN1 Gene

Molecular function for CTXN1 Gene

UniProtKB/Swiss-Prot Function:
May mediate extracellular or intracellular signaling of cortical neurons during forebrain development.

Phenotypes for CTXN1 Gene

genes like me logo Genes that share phenotypes with CTXN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CTXN1

miRNA for CTXN1 Gene

miRTarBase miRNAs that target CTXN1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTXN1 Gene

Localization for CTXN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTXN1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTXN1 gene
Compartment Confidence
plasma membrane 2
nucleus 2
extracellular 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CTXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0031224 intrinsic component of membrane IEA --
genes like me logo Genes that share ontologies with CTXN1: view

Pathways & Interactions for CTXN1 Gene

SuperPathways for CTXN1 Gene

No Data Available

Interacting Proteins for CTXN1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000313226%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000313226 for CTXN1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for CTXN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CTXN1 Gene

Drugs & Compounds for CTXN1 Gene

(1) Additional Compounds for CTXN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTXN1: view

Transcripts for CTXN1 Gene

mRNA/cDNA for CTXN1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(355) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTXN1 Gene

Cortexin 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTXN1 Gene

No ASD Table

Relevant External Links for CTXN1 Gene

GeneLoc Exon Structure for
CTXN1
ECgene alternative splicing isoforms for
CTXN1

Expression for CTXN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTXN1 Gene

mRNA differential expression in normal tissues according to GTEx for CTXN1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.6), Brain - Putamen (basal ganglia) (x7.4), Brain - Caudate (basal ganglia) (x6.6), Brain - Hippocampus (x4.7), and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for CTXN1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTXN1 Gene



Protein tissue co-expression partners for CTXN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTXN1 Gene:

CTXN1

SOURCE GeneReport for Unigene cluster for CTXN1 Gene:

Hs.657978
genes like me logo Genes that share expression patterns with CTXN1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CTXN1 Gene

Orthologs for CTXN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTXN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTXN1 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia CTXN1 34 35
  • 96.75 (n)
cow
(Bos Taurus)
Mammalia CTXN1 34 35
  • 94.72 (n)
mouse
(Mus musculus)
Mammalia Ctxn1 34 16 35
  • 93.09 (n)
rat
(Rattus norvegicus)
Mammalia Ctxn1 34
  • 91.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CTXN1 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTXN1 35
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CTXN1 (2 of 2) 35
  • 61 (a)
OneToMany
CTXN1 (1 of 2) 35
  • 54 (a)
OneToMany
Species where no ortholog for CTXN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTXN1 Gene

ENSEMBL:
Gene Tree for CTXN1 (if available)
TreeFam:
Gene Tree for CTXN1 (if available)

Paralogs for CTXN1 Gene

Paralogs for CTXN1 Gene

(2) SIMAP similar genes for CTXN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTXN1: view

Variants for CTXN1 Gene

Sequence variations from dbSNP and Humsavar for CTXN1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs138385134 Likely benign 7,927,274(+) CAGAG(C/T)GCCCA upstream-variant-2KB, reference, synonymous-codon
rs143337629 Uncertain significance 7,927,239(+) AGGCC(A/G)CGTAG upstream-variant-2KB, reference, missense
rs11542187 Benign 7,928,091(-) TAGAC(A/G)TTGAC upstream-variant-2KB, reference, missense
rs11542188 Benign 7,927,241(-) CCCTA(C/T)GCGGC upstream-variant-2KB, reference, synonymous-codon
rs12976850 Benign 7,927,167(+) GGGCT(A/C)CCTGG upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CTXN1 Gene

Variant ID Type Subtype PubMed ID
nsv953961 CNV deletion 24416366
nsv833733 CNV gain 17160897
nsv1136274 CNV deletion 24896259
nsv1072318 CNV deletion 25765185

Variation tolerance for CTXN1 Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTXN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTXN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTXN1 Gene

Disorders for CTXN1 Gene

Relevant External Links for CTXN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTXN1

No disorders were found for CTXN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTXN1 Gene

Publications for CTXN1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Cortexin and combination of nitrite with cortexin decrease swelling and destruction of cerebellar neurons in hemorrhagic stroke. (PMID: 19650315) Reutov V.P. … Chailakhyan L.M. (Dokl. Biol. Sci. 2009) 22 64
  3. [Use of cortexin in the early rehabilitation period of ischemic stroke of moderate severity]. (PMID: 19672239) Nurguzhaev E.S. … Abdil'manova B.R. (Zh Nevrol Psikhiatr Im S S Korsakova 2009) 22 64
  4. [Cytoprotective effect of neuropeptides on immunocompetent cells (in vitro study)]. (PMID: 19803367) Garmanchuk L.V. … Kul'chikov A.E. (Eksp Klin Farmakol 2009) 22 64
  5. Purification and mechanism of action of "cortexin," a novel antihypertensive protein hormone from kidney and its role in essential hypertension in men. (PMID: 20409952) Chakraborty S. … Sinha A.K. (J Am Soc Hypertens 2009) 22 64

Products for CTXN1 Gene

Sources for CTXN1 Gene

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