Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CTU1 Gene

protein-coding   GIFtS: 48
GCID: GC19M051601

Cytosolic Thiouridylase Subunit 1

(Previous names: ATP binding domain 3, cytosolic thiouridylase subunit 1...)
(Previous symbol: ATPBD3)
  Search for CTU1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cytosolic Thiouridylase Subunit 11 2     Cytosolic Thiouridylase Subunit 1 Homolog (S. Pombe)1
ATPBD31 2 3 5     Cancer-Associated Protein2
ATP Binding Domain 31 2     Cytoplasmic TRNA 2-Thiolation Protein 12
Cancer-Associated Gene Protein2 3     Cytosolic Thiouridylase Subunit 1 Homolog2
Cytoplasmic TRNA Adenylyltransferase 12 3     EC 2.7.7.-3
NCS62 3     EC 2.7.78
ATP-Binding Domain-Containing Protein 32 3     

External Ids:    HGNC: 295901   Entrez Gene: 903532   Ensembl: ENSG000001425447   OMIM: 6126945   UniProtKB: Q7Z7A33   

Export aliases for CTU1 gene to outside databases

Previous GC identifers: GC19M056295 GC19M047934


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CTU1 Gene:
CTU1 (cytosolic thiouridylase subunit 1) is a protein-coding gene. GO annotations related to this gene include tRNA binding and transferase activity.

UniProtKB/Swiss-Prot: CTU1_HUMAN, Q7Z7A3
Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and
tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required
for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from
thiocarboxylated URM1 onto the uridine of tRNAs at wobble position




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CTU1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CTU1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTU1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

CTU1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTU1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051601:  view genomic region     (about GC identifiers)

Start:
51,600,863 bp from pter      End:
51,611,647 bp from pter
Size:
10,785 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CTU1_HUMAN, Q7Z7A3 (See protein sequence)
Recommended Name: Cytoplasmic tRNA 2-thiolation protein 1  
Size: 348 amino acids; 36450 Da
Subunit: Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with
CTU2/NCS2
Secondary accessions: A8K558 Q96GZ7

Explore the universe of human proteins at neXtProt for CTU1: NX_Q7Z7A3

Explore proteomics data for CTU1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CTU1 (Q7Z7A3) (see all 8)
     AETVLMN  SGQALCG  TGHNADD  LEAARPSA 


    See CTU1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660275.2  
    ENSEMBL proteins: 
     ENSP00000390011  

    CTU1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CTU1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CTU1
    GenScript Custom Purified and Recombinant Proteins Services for CTU1
    Novus Biologicals CTU1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTU1

    CTU1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CTU1
    OriGene Custom Antibody Services for CTU1
    Novus Biologicals CTU1 Antibody
    Abcam antibodies for CTU1
    Cloud-Clone Corp. Antibodies for CTU1
    ThermoFisher Antibodies for CTU1
    LSBio Antibodies in human, mouse, rat for CTU1

    CTU1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CTU1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CTU1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CTU1
    Cloud-Clone Corp. CLIAs for CTU1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR011063 tRNA-lysidine/thiocyt_synth
     IPR012089 2-thiocytidine_tRNA_synth_TtcA
     IPR000541 Ncs6/Tuc1/Ctu1
     IPR014729 Rossmann-like_a/b/a_fold

    Graphical View of Domain Structure for InterPro Entry Q7Z7A3

    ProtoNet protein and cluster: Q7Z7A3

    2 Blocks protein domains:
    IPB000541 Protein of unknown function UPF0021
    IPB011063 PP-loop


    UniProtKB/Swiss-Prot: CTU1_HUMAN, Q7Z7A3
    Similarity: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily


    CTU1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTU1_HUMAN, Q7Z7A3
    Function: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and
    tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required
    for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from
    thiocarboxylated URM1 onto the uridine of tRNAs at wobble position

         Enzyme Numbers (IUBMB): EC 2.7.7.-1 EC 2.7.72

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding IEA--
    GO:0005515protein binding IPI19017811
    GO:0005524ATP binding ----
    GO:0016740transferase activity ----
    GO:0016779nucleotidyltransferase activity IEA--
         
    CTU1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTU1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTU1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTU1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTU1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CTU1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CTU1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CTU1
    Predesigned siRNA for gene silencing in human, mouse, rat CTU1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CTU1

    Clone
    Products:
         
    OriGene clones in human, mouse for CTU1 (see all 8)
    OriGene ORF clones in mouse, rat for CTU1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTU1 (NM_145232)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTU1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTU1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CTU1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CTU1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTU1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CTU1_HUMAN, Q7Z7A3: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion3
    nucleus3
    chloroplast1
    endoplasmic reticulum1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol ISS--

    CTU1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CTU1 About    
    See pathways by source

    SuperPathContained pathways About
    1Sulfur relay system
    Sulfur relay system

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for CTU1):
        Sulfur relay system

    UniProtKB/Swiss-Prot: CTU1_HUMAN, Q7Z7A3
    Pathway: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis


    CTU1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTU1
    Interactions:

        Search GeneGlobe Interaction Network for CTU1

    Selected Interacting proteins for CTU1 (Q7Z7A33) via UniProtKB, MINT, STRING, and/or I2D (see all 66)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIN1Q135263I2D: score=3 
    COTL1Q140193I2D: score=2 
    CTPS1P178123I2D: score=2 
    MAPRE1Q156913I2D: score=2 
    RPSAP088653I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002098tRNA wobble uridine modification NAS19017811
    GO:0008033tRNA processing ----
    GO:0032447protein urmylation IEA--
    GO:0034227tRNA thio-modification NAS19017811

    CTU1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTU1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CTU1 gene: 
    NM_145232.3  

    Unigene Cluster for CTU1:

    Cytosolic thiouridylase subunit 1 homolog (S. pombe)
    Hs.148425  [show with all ESTs]
    Unigene Representative Sequence: NM_145232
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000421832(uc010eop.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CTU1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CTU1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CTU1
    Predesigned siRNA for gene silencing in human, mouse, rat CTU1
    Clone
    Products:
         
    OriGene clones in human, mouse for CTU1 (see all 8)
    OriGene ORF clones in mouse, rat for CTU1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTU1 (NM_145232)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTU1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTU1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CTU1
    OriGene qSTAR qPCR primer pairs in human, mouse for CTU1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTU1
      QuantiTect SYBR Green Assays in human, mouse, rat CTU1
      QuantiFast Probe-based Assays in human, mouse, rat CTU1

    Additional mRNA sequence: 

    AK291173.1 BC009037.2 

    2 DOTS entries:

    DT.95369229  DT.75103154 

    Selected AceView cDNA sequences (see all 41):

    CR597220 CR608929 BX282661 CK823037 CK823003 BU632056 BQ100968 BX440723 
    AI651542 BE407299 AI376601 NM_145232 BC009037 CK823002 AI831882 CA424069 
    BX380318 BU633522 BQ684480 AW262002 CD515538 BE409635 CK823036 BX363108 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CTU1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTCCTAC
    CTU1 Expression
    About this image

    CTU1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTU1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.148425
        Custom PCR Arrays for CTU1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CTU1
    OriGene qSTAR qPCR primer pairs in human, mouse for CTU1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTU1
    QuantiTect SYBR Green Assays in human, mouse, rat CTU1
    QuantiFast Probe-based Assays in human, mouse, rat CTU1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTU1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CTU1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctu11 , 5 cytosolic thiouridylase subunit 1 homolog (S. pombe)1, 5 82.99(n)1
    90.15(a)1
      7 (28.26 cM)5
    2331891  NM_145582.11  NP_663557.11 
     436720165 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc553952 hypothetical protein MGC55395 77.74(n)   393098  BC044158.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80786
    --
    48(a)
    1 ↔ 1
    2R(4984436-4985972)
    worm
    (Caenorhabditis elegans)
    Secernentea tut-16
    Protein TUT-1 (tut-1) mRNA, complete cds
    40(a)
    1 ↔ 1
    IV(119274-121707) WBGene00017928
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NCS66
    Protein required for thiolation of the uridine at ...
    44(a)
    1 ↔ 1
    VII(92512-93591) YGL211W


    ENSEMBL Gene Tree for CTU1 (if available)
    TreeFam Gene Tree for CTU1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CTU1 gene

    CTU1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CTU1
    PGOHUM00000259416


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CTU1 (see all 273)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1396237081,2
    C--51600398(+) TGATG-/TG    
       CTTAC
    TGCTT
    1 -- ds50010--------
    rs25695031,2
    C,A--51600404(+) TGCTTA/GCTGTC 1 -- ds50013Minor allele frequency- G:0.20WA NA CSA 5
    rs25695041,2
    C,F,A--51600576(+) AGTGAG/AGACAG 1 -- ds500112Minor allele frequency- A:0.30NA WA CSA EA 375
    rs1168236651,2
    C,F--51600638(+) GAGGAG/CAGAAT 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs730510821,2
    C,F--51600666(+) GGACCC/TTGGAG 1 -- ds50011Minor allele frequency- T:0.05NA 120
    rs361204991,2
    C--51600772(+) AGTTT-/GAGATTC 1 -- ds50012Minor allele frequency- GA:0.25NA CSA 4
    rs104033521,2
    C,F--51600909(+) TCTTCC/TATTTC 1 -- ut312Minor allele frequency- T:0.15WA 120
    rs104039421,2
    C,F,A,H--51600921(+) TCCCAA/GTGGTG 1 -- ut3120Minor allele frequency- G:0.46NS EA WA NA CSA 2227
    rs671228411,2
    C--51600945(-) CCCCG-/CCCCCC 1 -- ut311Minor allele frequency- C:0.00NA 2
    rs129740981,2
    C--51600952(+) GGGGGC/GGGGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CTU1 (51600863 - 51611647 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CTU1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912293CNV Loss21882294
    esv34104CNV Loss18971310
    nsv912292CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTU1
    DNA2.0 Custom Variant and Variant Library Synthesis for CTU1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612694    OMIM disorders: --


    CTU1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CTU1
    Human Genome Epidemiology (HuGE) Navigator: CTU1 (1 document)

    Export disorders for CTU1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CTU1 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with CTU1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. (PubMed id 19017811)1, 2, 3 Schlieker C.D....Ploegh H.L. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 90353 HGNC: 29590 AceView: LOC90353 Ensembl:ENSG00000142544 euGenes: HUgn90353
    ECgene: CTU1 Kegg: 90353 H-InvDB: CTU1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CTU1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CTU1 gene:
    Search GeneIP for patents involving CTU1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CTU1   OriGene RNAi products in human, mouse, rat for CTU1  
     OriGene qPCR primer pairs and template standards for CTU1   OriGene Protein Over-expression Lysate for CTU1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CTU1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CTU1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CTU1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CTU1   OriGene Custom Protein Services for CTU1  

     
     
     Block miRNA regulation of human, mouse, rat CTU1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CTU1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTU1 Predesigned siRNA for gene silencing in human, mouse, rat CTU1
     QuantiFast Probe-based Assays in human, mouse, rat CTU1 QuantiTect SYBR Green Assays in human, mouse, rat CTU1
     Custom PCR Arrays for CTU1 Search Chromatin IP Primers for CTU1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTU1  Search GeneGlobe Interaction Network for CTU1
     Search Regulatory tfbs for CTU1
     GenScript Custom Purified and Recombinant Proteins Services for CTU1 GenScript cDNA clones with any tag delivered in your preferred vector for CTU1
     GenScript Custom Assay Services for CTU1 GenScript Custom overexpressing Cell Line Services for CTU1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CTU1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CTU1 antibodies
     CTU1 lysates
     Antibodies for CTU1
     See all of Abcam's Antibodies, Kits and Proteins for CTU1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CTU1
     Antibodies for CTU1
     ELISAs for CTU1
     CLIAs for CTU1



     Browse ESI BIO Cell Lines and PureStem Progenitors for CTU1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTU1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CTU1
     Browse SwitchGear Promoter luciferase reporter plasmids for CTU1
     ThermoFisher Antibodies for CTU1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTU1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTU1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTU1
     LSBio Antibodies in human, mouse, rat for CTU1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CTU1 gene at Home site.
    Version: 3.12.164 25 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4