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Aliases for CTTNBP2NL Gene

Aliases for CTTNBP2NL Gene

  • CTTNBP2 N-Terminal Like 2 3 5
  • KIAA1433 4

External Ids for CTTNBP2NL Gene

Previous GeneCards Identifiers for CTTNBP2NL Gene

  • GC01P112651
  • GC01P112740
  • GC01P112938
  • GC01P110795

Summaries for CTTNBP2NL Gene

GeneCards Summary for CTTNBP2NL Gene

CTTNBP2NL (CTTNBP2 N-Terminal Like) is a Protein Coding gene. GO annotations related to this gene include protein phosphatase 2A binding. An important paralog of this gene is CTTNBP2.

Gene Wiki entry for CTTNBP2NL Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTTNBP2NL Gene

Genomics for CTTNBP2NL Gene

Regulatory Elements for CTTNBP2NL Gene

Enhancers for CTTNBP2NL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CTTNBP2NL on UCSC Golden Path with GeneCards custom track

Promoters for CTTNBP2NL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CTTNBP2NL on UCSC Golden Path with GeneCards custom track

Genomic Location for CTTNBP2NL Gene

112,396,178 bp from pter
112,463,456 bp from pter
67,279 bases
Plus strand

Genomic View for CTTNBP2NL Gene

Genes around CTTNBP2NL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTTNBP2NL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTTNBP2NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTTNBP2NL Gene

Proteins for CTTNBP2NL Gene

  • Protein details for CTTNBP2NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    CTTNBP2 N-terminal-like protein
    Protein Accession:
    Secondary Accessions:
    • B3KMS5
    • Q96B40

    Protein attributes for CTTNBP2NL Gene

    639 amino acids
    Molecular mass:
    70158 Da
    Quaternary structure:
    • Interacts with CTTN/cortactin; this interaction may redistribute CTTN to stress fibers (By similarity). May form homomers. May interact with MOB4, PPP2R1A, PPP2CB, STK24, STK25, STK26, STRN4, STRIP1 and STRIP2.
    • Sequence=BAA92671.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for CTTNBP2NL Gene

Proteomics data for CTTNBP2NL Gene at MOPED

Post-translational modifications for CTTNBP2NL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTTNBP2NL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTTNBP2NL Gene

Domains & Families for CTTNBP2NL Gene

Protein Domains for CTTNBP2NL Gene


Suggested Antigen Peptide Sequences for CTTNBP2NL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CTTNBP2NL: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CTTNBP2NL Gene

Function for CTTNBP2NL Gene

genes like me logo Genes that share phenotypes with CTTNBP2NL: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTTNBP2NL Gene

Localization for CTTNBP2NL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTTNBP2NL Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with stress fibers. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CTTNBP2NL Gene COMPARTMENTS Subcellular localization image for CTTNBP2NL gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for CTTNBP2NL Gene

Pathways & Interactions for CTTNBP2NL Gene

SuperPathways for CTTNBP2NL Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTTNBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032410 negative regulation of transporter activity IMP 24218568
genes like me logo Genes that share ontologies with CTTNBP2NL: view

No data available for Pathways by source and SIGNOR curated interactions for CTTNBP2NL Gene

Drugs & Compounds for CTTNBP2NL Gene

No Compound Related Data Available

Transcripts for CTTNBP2NL Gene

Unigene Clusters for CTTNBP2NL Gene

CTTNBP2 N-terminal like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTTNBP2NL Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP3: - - - -

Relevant External Links for CTTNBP2NL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTTNBP2NL Gene

mRNA expression in normal human tissues for CTTNBP2NL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTTNBP2NL Gene

This gene is overexpressed in Adrenal (34.1) and Cervix (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTTNBP2NL Gene

SOURCE GeneReport for Unigene cluster for CTTNBP2NL Gene Hs.744100

genes like me logo Genes that share expression patterns with CTTNBP2NL: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CTTNBP2NL Gene

Orthologs for CTTNBP2NL Gene

This gene was present in the common ancestor of animals.

Orthologs for CTTNBP2NL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTTNBP2NL 35
  • 89.25 (n)
  • 92.02 (a)
  • 92 (a)
(Canis familiaris)
Mammalia CTTNBP2NL 35
  • 87.79 (n)
  • 90.61 (a)
  • 91 (a)
(Mus musculus)
Mammalia Cttnbp2nl 35
  • 87.04 (n)
  • 89.81 (a)
Cttnbp2nl 16
Cttnbp2nl 36
  • 90 (a)
(Pan troglodytes)
Mammalia CTTNBP2NL 35
  • 99.48 (n)
  • 99.37 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Cttnbp2nl 35
  • 86.99 (n)
  • 89.03 (a)
(Monodelphis domestica)
Mammalia CTTNBP2NL 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia CTTNBP2NL 36
  • 83 (a)
(Gallus gallus)
  • 73.26 (n)
  • 78.65 (a)
  • 73 (a)
(Anolis carolinensis)
Reptilia CTTNBP2NL 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cttnbp2nl 35
  • 66.67 (n)
  • 68.2 (a)
(Danio rerio)
Actinopterygii cttnbp2nlb 35
  • 56.97 (n)
  • 55.03 (a)
cttnbp2nl 36
  • 49 (a)
CTTNBP2NL (1 of 2) 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10915 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea C49H3.6 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for CTTNBP2NL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTTNBP2NL Gene

Gene Tree for CTTNBP2NL (if available)
Gene Tree for CTTNBP2NL (if available)

Paralogs for CTTNBP2NL Gene

Paralogs for CTTNBP2NL Gene

(3) SIMAP similar genes for CTTNBP2NL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CTTNBP2NL: view

Variants for CTTNBP2NL Gene

Sequence variations from dbSNP and Humsavar for CTTNBP2NL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1175640 - 112,456,378(+) TAACC(A/G)TGTCC reference, missense
rs12137578 - 112,456,717(+) CTTCC(A/G)GTGGG reference, missense
rs11035 -- 112,460,067(-) ACTAA(A/T)ATTGT utr-variant-3-prime
rs962401 -- 112,412,144(+) ACCAA(C/G/T)TTGTT intron-variant
rs962402 -- 112,412,372(+) ATGCA(A/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTTNBP2NL Gene

Variant ID Type Subtype PubMed ID
esv27061 CNV Gain+Loss 19812545
nsv831081 CNV Loss 17160897
esv2660196 CNV Deletion 23128226
esv267691 CNV Insertion 20981092
esv273441 CNV Insertion 20981092
nsv159431 CNV Insertion 16902084
nsv159278 CNV Loss 16902084
nsv506955 CNV Insertion 20534489

Variation tolerance for CTTNBP2NL Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CTTNBP2NL Gene

Disorders for CTTNBP2NL Gene

Relevant External Links for CTTNBP2NL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CTTNBP2NL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTTNBP2NL Gene

Publications for CTTNBP2NL Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for CTTNBP2NL Gene

Sources for CTTNBP2NL Gene