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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTTNBP2NL Gene

protein-coding   GIFtS: 48
GCID: GC01P112938

CTTNBP2 N-terminal like

 Explore 5 diseases affiliated with
CTTNBP2NL via our new
 Human Malady Compendium 
Biological research products
for CTTNBP2NL
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
CTTNBP2 N-Terminal Like1 2
DKFZp547A0231
CTTNBP2 N-Terminal-Like Protein2
KIAA14333

External Ids:    HGNC: 253301   Entrez Gene: 559172   Ensembl: ENSG000001430797   UniProtKB: Q9P2B43   

Export aliases for CTTNBP2NL gene to outside databases

Previous GC identifers: GC01P112651 GC01P112740 GC01P110795


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for CTTNBP2NL


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTTNBP2NL gene promoter:
         SRF   AML1a   GCNF   SRF (504 AA)   STAT5A   POU2F1a   HSF2   GCNF-1   c-Myb   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTTNBP2NL promoter sequence
   Search SABiosciences Chromatin IP Primers for CTTNBP2NL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTTNBP2NL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

CTTNBP2NL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTTNBP2NL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P112938:  view genomic region     (about GC identifiers)

Start:
112,938,800 bp from pter      End:
113,003,786 bp from pter
Size:
64,987 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CT2NL_HUMAN, Q9P2B4 (See protein sequence)
Recommended Name: CTTNBP2 N-terminal-like protein  
Size: 639 amino acids; 70158 Da
Sequence caution: Sequence=BAA92671.1; Type=Erroneous initiation;
Secondary accessions: Q96B40

Explore the universe of human proteins at neXtProt for CTTNBP2NL: NX_Q9P2B4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2B4

  • CTTNBP2NL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061174.1  
    ENSEMBL proteins: 
     ENSP00000271277   ENSP00000390976  

    Human Recombinant Protein Products: 
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    Uscn Proteins for CTTNBP2NL

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015629actin cytoskeleton IDA--


    CTTNBP2NL for ontologies           About GeneDecksing



    CTTNBP2NL Antibody Products: 
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    Uscn Antibodies for CTTNBP2NL
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    Uscn ELISAs and CLIAs for CTTNBP2NL


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CTTNBP2NL for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019131 Cortactin-binding_p2_N

    Graphical View of Domain Structure for InterPro Entry Q9P2B4

    ProtoNet protein and cluster: Q9P2B4


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: CTTNBP2NL
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTTNBP2NL
    8/104 QIAGEN miScript miRNA Assays for microRNAs that regulate CTTNBP2NL (see all 104):
    hsa-miR-582-3p hsa-miR-323-3p hsa-miR-576-3p hsa-miR-3607-3p hsa-miR-4272 hsa-miR-134 hsa-miR-30d hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidCTTNBP2NL 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTTNBP2NL (see all 7)
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19156129


    CTTNBP2NL for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CTTNBP2NL:
     Increased 8N DNA content  Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTTNBP2NL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/20 Interacting proteins for CTTNBP2NL (Q9P2B41, 3 ENSP000002712774) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK24Q9Y6E01, 3, ENSP000003657304EBI-1774273,EBI-1054809 I2D: score=2 STRING: ENSP00000365730
    STRNO438151, 3, ENSP000002639184EBI-1774273,EBI-1046642 I2D: score=2 STRING: ENSP00000263918
    FAM40AQ5VSL91, 3EBI-1774273,EBI-1773588 I2D: score=2 
    MOB4Q9Y3A31, 3, ENSP000003157024EBI-1774273,EBI-713935 I2D: score=2 STRING: ENSP00000315702
    MST4Q9P2891, 3, ENSP000003778674EBI-1774273,EBI-1774248 I2D: score=2 STRING: ENSP00000377867
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTTNBP2NL
    Search CenterWatch for drugs/clinical trials and news about CTTNBP2NL / CT2NL 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CTTNBP2NL gene: 
    NM_018704.2  

    Unigene Cluster for CTTNBP2NL:

    CTTNBP2 N-terminal like
    Hs.744100  [show with all ESTs]
    Unigene Representative Sequence: NM_018704
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000271277(uc001ebx.3) ENST00000496194 ENST00000441739

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTTNBP2NL
    8/104 QIAGEN miScript miRNA Assays for microRNAs that regulate CTTNBP2NL (see all 104):
    hsa-miR-582-3p hsa-miR-323-3p hsa-miR-576-3p hsa-miR-3607-3p hsa-miR-4272 hsa-miR-134 hsa-miR-30d hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidCTTNBP2NL 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTTNBP2NL (see all 7)
    OriGene shRNA RFP: CTTNBP2NL
    OriGene siRNA: CTTNBP2NL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTTNBP2NL
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTTNBP2NL
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    Additional cDNA sequence: 

    AK022544.1 AK023340.1 AK055261.1 AK092791.1 AL359565.1 BC016029.1 

    13 DOTS entries:

    DT.80102096  DT.102830262  DT.91722712  DT.100841455  DT.91722710  DT.121398227  DT.303630  DT.422696 
    DT.95159006  DT.95279400  DT.95317308  DT.302253  DT.95374481 

    24/204 AceView cDNA sequences (see all 204):

    AI478886 BF111529 Z39449 BE141863 BU742931 AA232932 BQ014048 AI565906 
    AA644645 AW847733 AI085123 AI290423 AK055261 AL539535 N58935 AW449060 
    BP364132 AI952922 AL601394 AA232944 AL047986 AA253100 AW847736 BQ776231 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CTTNBP2NL    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:        -     -     -                                             
    SP2:              -     -                                             
    SP3:        -     -     -                       -                     
    SP4:                                                                  


    ECgene alternative splicing isoforms for CTTNBP2NL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTTNBP2NL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGAAGTCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CTTNBP2NL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Gut TubeHindgutGut Tube
    Gut TubeMidgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CTTNBP2NL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTTNBP2NL

    SOURCE GeneReport for Unigene cluster: Hs.744100
        SABiosciences Custom PCR Arrays for CTTNBP2NL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTTNBP2NL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CTTNBP2NL gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CTTNBP2NL1 CTTNBP2 N-terminal like 72.99(n)
    78.21(a)
      419870  XM_417997.3  XP_417997.3 
    lizard
    (Anolis carolinensis)
    Reptilia CTTNBP2NL6
    --
    76(a)
    1 ↔ 1
    4(127905346-127920830)
    zebrafish
    (Danio rerio)
    Actinopterygii cttnbp2nl1 CTTNBP2 N-terminal like 55.01(n)
    52.2(a)
      556247  NM_001077371.1  NP_001070839.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG109156
    --
    22(a)
    1 → many
    2R(14048225-14051714)
    worm
    (Caenorhabditis elegans)
    Secernentea C49H3.66
    Protein C49H3.6, isoform a
    19(a)
    1 → many
    IV(7903726-7907071)


    ENSEMBL Gene Tree for CTTNBP2NL (if available)
    TreeFam Gene Tree for CTTNBP2NL (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTTNBP2NL gene
    CTTNBP22  FILIP12  FILIP1L2  LUZP12  
    3 SIMAP similar genes for CTTNBP2NL using alignment to 2 protein entries:     CT2NL_HUMAN (see all proteins):
    DKFZp547A023    CTTNBP2    FILIP1L

    CTTNBP2NL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1235 NCBI SNPs in CTTNBP2NL are shown (see all 1235    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1450910221,2
    --112936809(+) GACAGA/GGCGAG 1 -- us2k10--------
    rs2004404401,2
    C--112936851(-) TTTTTC/TTNNNN 1 -- us2k10--------
    rs1883662231,2
    --112936868(+) AGGAGC/TTGATT 1 -- us2k10--------
    rs1421412991,2
    --112936922(+) AGCTTA/GTTCTC 1 -- us2k10--------
    rs24887691,2
    C,F,O,A,H,--112936957(-) AAGTGT/CCTCAT 1 -- us2k124Minor allele frequency- C:0.45NS EA NA WA CSA 2353
    rs1901816181,2
    --112937073(+) TCAGAC/TATTTT 1 -- us2k10--------
    rs24925041,2
    C,F,O,A,--112937090(+) AGTCAG/ATATTT 1 -- us2k1 tfbs314Minor allele frequency- A:0.44NA WA CSA EA 509
    rs24887681,2
    C,F,A,H,--112937128(-) GCTAAG/AATGAG 1 -- us2k115Minor allele frequency- A:0.44NS EA NA WA CSA 791
    rs1449548031,2
    --112937272(+) GAGAT-/GGACCC 1 -- us2k10--------
    rs1431467171,2
    --112937418(+) TGGAGC/TCATAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CTTNBP2NL (112938800 - 113003786 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CTTNBP2NL
         2 CNVs: 5510 64617

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTTNBP2NL
    DNA2.0 Custom Variant and Variant Library Synthesis for CTTNBP2NL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CTTNBP2NL for disorders           About GeneDecksing

    5 diseases for CTTNBP2NL:    About MalaCards
    cerebral cavernous malformations    cavernous malformation    cerebral cavernous malformations 3    dermatofibrosarcoma
    cerebritis


    Export disorders for CTTNBP2NL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTTNBP2NL gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with CTTNBP2NL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55917 HGNC: 25330 AceView: DKFZp547A023 Ensembl:ENSG00000143079 euGenes: HUgn55917
    ECgene: CTTNBP2NL H-InvDB: CTTNBP2NL

    (According to HUGE)
    About This Section
    HUGE: KIAA1433

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTTNBP2NL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CTTNBP2NL gene:
    Search GeneIP for patents involving CTTNBP2NL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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