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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTTN Gene

protein-coding   GIFtS: 63
GCID: GC11P070244

Cortactin

(Previous name: ems1 sequence (mammary tumor and squamous cell carcinoma-associated...)
(Previous symbol: EMS1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
cortactin1 2     1110020L01Rik2
EMS11 2 3 5     amplaxin2
Ems1 Sequence (Mammary Tumor And Squamous Cell Carcinoma-Associated
(P80/85 Src Substrate)1 2
     Src Substrate Cortactin2
Oncogene EMS12 3     Amplaxin3

External Ids:    HGNC: 33381   Entrez Gene: 20172   Ensembl: ENSG000000857337   OMIM: 1647655   UniProtKB: Q142473   

Export aliases for CTTN gene to outside databases

Previous GC identifers: GC11P069971 GC11P069922 GC11P066505


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTTN Gene:
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein
is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1)
regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and
cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a
caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis.
Three splice variants that encode different isoforms have been identified for this gene. (provided by RefSeq, May
2010)

GeneCards Summary for CTTN Gene: 
CTTN (cortactin) is a protein-coding gene. Diseases associated with CTTN include breast squamous cell carcinoma, and ethmoid sinus adenocarcinoma, and among its related super-pathways are Development Slit-Robo signaling and Neurophysiological process Receptor-mediated axon growth repulsion. GO annotations related to this gene include protein binding. An important paralog of this gene is DBN1.

UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247
Function: Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and
MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated
endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the
invasiveness of cancer cells, and the formation of metastases

Gene Wiki entry for CTTN (Cortactin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTTN gene promoter:
         HFH-3   AML1a   FOXJ2 (long isoform)   POU6F1 (c2)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTTN promoter sequence
   Search SABiosciences Chromatin IP Primers for CTTN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13

CTTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTTN gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P070244:  view genomic region     (about GC identifiers)

Start:
70,244,510 bp from pter      End:
70,282,690 bp from pter
Size:
38,181 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247 (See protein sequence)
Recommended Name: Src substrate cortactin  
Size: 550 amino acids; 61586 Da
Subunit: Interacts with SHANK2 and SHANK3 (via its SH3 domain). Also interacts with FGD1. Identified in a complex
containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with ABL2 (By similarity).
Interacts with PLXDC2 and SRCIN1. Interacts with SAMSN1 (via SH3 domain). Interacts (via SH3 domain) with ASAP1
(via Pro-rich region). Interacts with DNM2 and FER. Forms a complex made of ABL1 and MYLK. Interacts with
CTTNBP2NL; this interaction may target CTTN to stress fibers. Interacts with CTTNBP2; this interaction may target
CTTN at the cell cortex or dendritic spines
Subcellular location: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell
projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Note=Associated with
membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity).
In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by
glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity)
2 PDB 3D structures from and Proteopedia for CTTN:
1X69 (3D)        2D1X (3D)    
Secondary accessions: Q8N707 Q96H99
Alternative splicing: 3 isoforms:  Q14247-1   Q14247-2   Q14247-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CTTN: NX_Q14247

Explore proteomics data for CTTN at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in
    hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By
    similarity). Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular
    growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC
    promotes MYLK binding
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14247

  • CTTN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CTTN Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001171669.1  NP_005222.2  NP_612632.1  

    ENSEMBL proteins: 
     ENSP00000317189   ENSP00000301843   ENSP00000365745   ENSP00000409014   ENSP00000433552  
     ENSP00000434669   ENSP00000377348   ENSP00000431421   ENSP00000436613   ENSP00000439762  

    Human Recombinant Protein Products for CTTN: 
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    Novus Biologicals CTTN Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTTN 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle ISS--
    GO:0005737cytoplasm ISS--
    GO:0005856cytoskeleton IEA--
    GO:0005938cell cortex ISS--
    GO:0030027lamellipodium ISS--

    CTTN for ontologies           About GeneDecksing



    CTTN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CTTN
    R&D Systems Antibodies for CTTN (Cortactin)
    Cell Signaling Technology (CST) Antibodies for CTTN  (cortactin)
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    Abcam antibodies for CTTN
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    ThermoFisher Antibody for CTTN
    LSBio Antibodies in human, mouse, rat for CTTN 

    Assay Products for CTTN: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CTTN 
    Cloud-Clone Corp. CLIAs for CTTN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR003134 Hs1_Cortactin
     IPR015503 Cortactin
     IPR000108 p67phox
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q14247

    ProtoNet protein and cluster: Q14247

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB003134 Hs1/Cortactin


    UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247
    Domain: The SH3 motif may mediate binding to the cytoskeleton
    Similarity: Contains 7 cortactin repeats
    Similarity: Contains 1 SH3 domain


    CTTN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRC8_HUMAN, Q14247
    Function: Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and
    MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated
    endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the
    invasiveness of cancer cells, and the formation of metastases

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15169891
         
    CTTN for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cttn):
     cardiovascular system  cellular  embryogenesis  immune system  mortality/aging 
     no phenotypic analysis  reproductive system  respiratory system 

    CTTN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CTTN: Cttntm1.2Okab Cttntm1.2Dvst

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CTTN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTTN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTTN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTTN 

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CTTN (see all 14):
    hsa-miR-3163 hsa-miR-142-3p hsa-miR-187* hsa-miR-1271 hsa-miR-548v hsa-miR-545 hsa-miR-20b* hsa-miR-182
    SwitchGear 3'UTR luciferase reporter plasmidCTTN 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTTN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CTTN About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit-Robo signaling
    Development Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.43
    Cytoskeleton remodeling Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    2Neurophysiological process Receptor-mediated axon growth repulsion
    Neurophysiological process Receptor-mediated axon growth repulsion0.94
    3Cell adhesion Cadherin-mediated cell adhesion
    Cell adhesion Cadherin-mediated cell adhesion1.00
    4Tight junction
    Tight junction
    5Syndecan-3-mediated signaling events
    Syndecan-3-mediated signaling events

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for CTTN
        Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Slit-Robo signaling
    Cell adhesion Cadherin-mediated cell adhesion


    1 Cell Signaling Technology (CST) Pathway for CTTN
        Cytoskeletal Signaling

    3 GeneGo (Thomson Reuters) Pathways for CTTN
        Neurophysiological process Receptor-mediated axon growth repulsion
    Development Slit-Robo signaling
    Cell adhesion Cadherin-mediated cell adhesion

    5 BioSystems Pathways for CTTN
        Pathogenic Escherichia coli infection
    E-cadherin signaling in the nascent adherens junction
    N-cadherin signaling events
    Syndecan-3-mediated signaling events
    FGF signaling pathway


    5         Kegg Pathways  (Kegg details for CTTN):
        Tight junction
    Bacterial invasion of epithelial cells
    Pathogenic Escherichia coli infection
    Shigellosis
    Proteoglycans in cancer


    CTTN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/690 Interacting proteins for CTTN (Q142471, 2, 3 ENSP000003018434) via UniProtKB, MINT, STRING, and/or I2D (see all 690)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAK1Q131532, 3, ENSP000002785684MINT-7945693 MINT-6541935 I2D: score=2 STRING: ENSP00000278568
    MTSS1O433122, 3, ENSP000003228044MINT-7306884 I2D: score=2 STRING: ENSP00000322804
    YWHABP319462, 3, ENSP000003001614MINT-8009879 I2D: score=1 STRING: ENSP00000300161
    CHD3Q128732, 3MINT-7945693 I2D: score=3 
    ASAP1Q9ULH12, 3, ENSP000003502974MINT-7145534 MINT-7145594 MINT-7145426 MINT-7145630 MINT-7145519 MINT-7145575 I2D: score=1 STRING: ENSP00000350297
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CTTN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTTN (SRC8)

    10/24 Novoseek inferred chemical compound relationships for CTTN gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ucs15a 77.8 1 16636290 (1)
    tyrosine 72.7 221 9748248 (5), 10952984 (5), 17420251 (5), 12851885 (5) (see all 90)
    cytochalasin d 55.5 4 7545676 (1), 10072547 (1), 15671060 (1)
    jasplakinolide 38.1 2 15030313 (1)
    phosphotyrosine 33.8 4 16442522 (2), 18240308 (1)
    threonine 32.2 6 16109479 (2), 9683637 (1), 15169891 (1), 18768925 (1) (see all 5)
    pip2 20.4 1 17217950 (1)
    serine 18.3 10 18768925 (4), 16109479 (2), 9683637 (1), 15169891 (1) (see all 6)
    matrigel 17.6 1 15242766 (1)
    thromboxane a2 15.7 2 10438543 (2)

    Search CenterWatch for drugs/clinical trials and news about CTTN / SRC8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CTTN gene (3 alternative transcripts): 
    NM_001184740.1  NM_005231.3  NM_138565.2  

    Unigene Cluster for CTTN:

    Cortactin
    Hs.596164  [show with all ESTs]
    Unigene Representative Sequence: NM_005231
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346329(uc010rqm.2 uc001opu.3 uc001opw.4 uc001opx.3)
    ENST00000301843(uc001opv.4) ENST00000482755 ENST00000527622 ENST00000376561
    ENST00000415461 ENST00000525276 ENST00000532334 ENST00000527962 ENST00000483662
    ENST00000498223 ENST00000525852 ENST00000393747 ENST00000529736 ENST00000533931
    ENST00000538675
    miRNA
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    Additional mRNA sequence: 

    AK091778.1 AK222613.1 AK291097.1 AK304582.1 BC008799.2 BC033889.1 M98343.1 

    24/31 DOTS entries (see all 31):

    DT.91882382  DT.447076  DT.100818545  DT.100818541  DT.91771079  DT.95183963  DT.91899683  DT.91976081 
    DT.92070660  DT.100030904  DT.100754041  DT.99960412  DT.120746422  DT.91771082  DT.92415497  DT.120746195 
    DT.120746431  DT.75105205  DT.91743354  DT.91993609  DT.87018110  DT.91866291  DT.92025209  DT.95170878 

    24/220 AceView cDNA sequences (see all 220):

    AA308550 CB130168 BQ962340 AA430469 BM989953 AA322557 BM845130 AI146717 
    AW166140 AW001339 CB148503 BC008799 T27704 BQ647254 BM993684 AI336244 
    AI302758 BU077769 AA113075 BM468617 BU541128 BE891493 BI062728 AA845427 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CTTN (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ·
    SP1:                          -                                   -           -     -                                               -     -                 -   
    SP2:                          -                                   -                 -                                               -     -                     
    SP3:                          -                                   -           -     -                                               -     -                     
    SP4:                                                                                                                                -     -                     
    SP5:                                                                                                                                -                           

    ExUns: 18c · 18d ^ 19 ^ 20
    SP1:  -     -               
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CTTN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTTN expression in normal human tissues (normalized intensities)      CTTN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAATTTCA
    CTTN Expression
    About this image


    CTTN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 3 entries
             salivary gland ; glandular cells   
             buccal mucosa   

    See CTTN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTTN

    SOURCE GeneReport for Unigene cluster: Hs.596164
        SABiosciences Expression via Pathway-Focused PCR Arrays including CTTN: 
              Cytoskeleton Regulators in human mouse rat
              Tight Junctions in human mouse rat
              Cell Motility in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CTTN gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cttn1 , 5 cortactin1, 5 84.74(n)1
    91.94(a)1
      7 (88.84 cM)5
    130431  NM_007803.51  NP_031829.21 
     1444357335 
    chicken
    (Gallus gallus)
    Aves CTTN1 cortactin 76.82(n)
    84.18(a)
      396455  NM_205468.1  NP_990799.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTTN6
    Uncharacterized protein
    73(a)
    1 ↔ 1
    GL343283.1(199331-232974)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.64932 Xenopus laevis mRNA for cortactin, complete cds 79.03(n)    AB027611.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc663252 similar to cortactin 77.75(n)   394016  BC055600.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cortactin6
    Cortactin
    40(a)
    1 ↔ 1
    3R(16887402-16890193)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ABP16
    Actin-binding protein of the cortical actin cytosk...
    9(a)
    1 → many
    III(265068-266846)


    ENSEMBL Gene Tree for CTTN (if available)
    TreeFam Gene Tree for CTTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTTN gene
    DBN12  HCLS12  DBNL2  
    4 SIMAP similar genes for CTTN using alignment to 8 protein entries:     SRC8_HUMAN (see all proteins):
    EMS1    HCLS1    SH3GL2    DBNL

    CTTN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1012 SNPs in CTTN are shown (see all 1012)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1886056291,2
    --70087672(+) CACGTC/GCCTGT 3 -- us2k10--------
    rs1813938331,2
    --70087673(+) ACGTGA/CCTGTA 3 -- us2k10--------
    rs1486523471,2
    C--70087806(+) CAAAC-/AAAAAA 3 -- us2k10--------
    rs1869685091,2
    --70087860(+) ATGGGA/GTCTAT 3 -- us2k10--------
    rs1458373691,2
    --70087904(+) AGCAAA/TCCTCT 3 -- us2k10--------
    rs1118791641,2
    C,F--70088066(+) TTTTTT/ATTTTT 3 -- us2k12Minor allele frequency- A:0.10CSA WA 120
    rs116015361,2
    H--70088121(+) cctcaG/Tcctcc 3 -- us2k10--------
    rs1498873741,2
    C--70088188(+) AAAAA-/TTTTTT 3 -- us2k10--------
    rs788873221,2
    C--70088227(-) GCCTGG/AGCAAC 3 -- us2k12Minor allele frequency- A:0.00NA 4
    rs345523781,2
    C,F--70088262(+) CAATCC/TTCCTG 3 -- us2k18Minor allele frequency- T:0.12NA WA CSA EA 251

    HapMap Linkage Disequilibrium report for CTTN (70244510 - 70282690 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CTTN: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CTTN
    DNA2.0 Custom Variant and Variant Library Synthesis for CTTN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 164765    OMIM disorders: --

    20/41 diseases for CTTN (see all 41):    About MalaCards
    breast squamous cell carcinoma    ethmoid sinus adenocarcinoma    aarskog-scott syndrome    squamous cell carcinoma of the head and neck
    ethmoid sinusitis    squamous cell carcinoma    laryngeal carcinoma    scott syndrome
    sinusitis    wiskott-aldrich syndrome    peptic ulcer    adenoid cystic carcinoma
    shigellosis    breast cancer    adenoiditis    laryngitis
    sporadic breast cancer    esophageal squamous cell carcinoma    polycystic kidney disease    gastric adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for CTTN:
    Carcinoma

    CTTN for disorders           About GeneDecksing

    10/23 Novoseek inferred disease relationships for CTTN gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hnscc 65 40 16912177 (6), 17909038 (3), 18931703 (3), 17483334 (3) (see all 9)
    carcinoma squamous cell 58.5 34 10955801 (3), 19125793 (2), 17909038 (2), 18607838 (2) (see all 20)
    wiskott-aldrich syndrome 51.5 3 12517700 (1), 15585574 (1), 15579908 (1)
    metastasis 45.7 56 15464244 (5), 17178864 (4), 16636290 (3), 18575752 (3) (see all 25)
    laryngeal carcinoma 43.9 10 19947248 (7), 18268491 (3)
    carcinoma 42.8 43 16280034 (3), 16912177 (3), 9054437 (3), 18776588 (2) (see all 20)
    tumors 41 120 19125793 (4), 16912177 (4), 19898426 (4), 18607838 (4) (see all 48)
    breast cancer 34.4 41 9747885 (6), 16636290 (3), 9380415 (3), 8945620 (3) (see all 17)
    cancer 32.5 41 19885549 (7), 16261345 (3), 18403644 (3), 18406052 (2) (see all 18)
    mammary tumor 29 5 16536875 (1), 9309140 (1), 18334127 (1), 9533029 (1)

    Genetic Association Database (GAD): CTTN
    Human Genome Epidemiology (HuGE) Navigator: CTTN (2 documents)

    Export disorders for CTTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTTN gene, integrated from 9 sources (see all 424):
    (articles sorted by number of sources associating them with CTTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. (PubMed id 16636290)1, 2, 9 Hashimoto S....Sabe H. (2006)
    2. A common cortactin gene variation confers differential susceptibility to severe asthma. (PubMed id 18521921)1, 4, 9 Ma S.F....Garcia J.G. (2008)
    3. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. (PubMed id 15574754)1, 2, 9 Nanda A.... St Croix B. (2004)
    4. Novel interaction of cortactin with endothelial cell myosin light chain kinase. (PubMed id 12408982)1, 2, 9 Dudek S.M....Garcia J.G. (2002)
    5. The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell- substratum contact sites. (PubMed id 8474448)1, 2, 9 Schuuring E.M.D.... Michalides R.J.A. (1993)
    6. Amplified region of chromosome band 11q13 in breast and squamous cell carcinomas encompasses three CpG islands telomeric of FGF3, including the expressed gene EMS1. (PubMed id 7685625)1, 3, 9 Brookes S....Peters G. (1993)
    7. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. (PubMed id 1532244)1, 2, 9 Schuuring E.M.D.... Michalides R.J.A. (1992)
    8. Dynamic microtubules regulate dendritic spine morphol ogy and synaptic plasticity. (PubMed id 19146815)1, 2 Jaworski J....Hoogenraad C.C. (2009)
    9. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2017 HGNC: 3338 AceView: CTTN Ensembl:ENSG00000085733 euGenes: HUgn2017
    ECgene: CTTN Kegg: 2017 H-InvDB: CTTN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTTN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTTN Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Cortactin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CTTN gene:
    Search GeneIP for patents involving CTTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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