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Aliases for CTTN Gene

Aliases for CTTN Gene

  • Cortactin 2 3 5
  • Ems1 Sequence (Mammary Tumor And Squamous Cell Carcinoma-Associated (P80/85 Src Substrate) 2 3
  • Oncogene EMS1 3 4
  • Amplaxin 3 4
  • EMS1 3 4
  • 1110020L01Rik 3

External Ids for CTTN Gene

Previous HGNC Symbols for CTTN Gene

  • EMS1

Previous GeneCards Identifiers for CTTN Gene

  • GC11P069971
  • GC11P069922
  • GC11P070244
  • GC11P066505

Summaries for CTTN Gene

Entrez Gene Summary for CTTN Gene

  • This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for CTTN Gene

CTTN (Cortactin) is a Protein Coding gene. Diseases associated with CTTN include ampulla of vater adenocarcinoma and ethmoid sinus cancer. Among its related pathways are Bacterial invasion of epithelial cells and Development Slit-Robo signaling. GO annotations related to this gene include profilin binding. An important paralog of this gene is DBN1.

UniProtKB/Swiss-Prot for CTTN Gene

  • Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).

Gene Wiki entry for CTTN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTTN Gene

Genomics for CTTN Gene

Regulatory Elements for CTTN Gene

Enhancers for CTTN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CTTN on UCSC Golden Path with GeneCards custom track

Promoters for CTTN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CTTN on UCSC Golden Path with GeneCards custom track

Genomic Location for CTTN Gene

Chromosome:
11
Start:
70,398,404 bp from pter
End:
70,436,584 bp from pter
Size:
38,181 bases
Orientation:
Plus strand

Genomic View for CTTN Gene

Genes around CTTN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTTN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTTN Gene

Proteins for CTTN Gene

  • Protein details for CTTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14247-SRC8_HUMAN
    Recommended name:
    Src substrate cortactin
    Protein Accession:
    Q14247
    Secondary Accessions:
    • Q8N707
    • Q96H99

    Protein attributes for CTTN Gene

    Size:
    550 amino acids
    Molecular mass:
    61586 Da
    Quaternary structure:
    • Interacts with SHANK2 and SHANK3 (via its SH3 domain). Also interacts with FGD1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with ABL2 (By similarity). Interacts with KCNA2 (via non-phosphorylated C-terminus) (PubMed:12151401). Interacts with PLXDC2 and SRCIN1. Interacts with SAMSN1 (via SH3 domain). Interacts (via SH3 domain) with ASAP1 (via Pro-rich region). Interacts (via SH3 domain) with DNM2 (By similarity). Interacts with ACTN1 (By similarity). Interacts with FER (PubMed:9722593). Forms a complex made of ABL1 and MYLK. Interacts with CTTNBP2NL; this interaction may target CTTN to stress fibers. Interacts with CTTNBP2; this interaction may target CTTN at the cell cortex or dendritic spines. Interacts with KCNH1 (PubMed:23144454).

    Three dimensional structures from OCA and Proteopedia for CTTN Gene

    Alternative splice isoforms for CTTN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTTN Gene

Proteomics data for CTTN Gene at MOPED

Post-translational modifications for CTTN Gene

  • Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (By similarity). Phosphorylated by PTK2/FAK1 in response to cell adhesion (By similarity). Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding.
  • Ubiquitination at Lys 87, Lys 124, Lys 161, Lys 171, Lys 181, Lys 208, Lys 235, and Lys 272
  • Modification sites at PhosphoSitePlus

Other Protein References for CTTN Gene

No data available for DME Specific Peptides for CTTN Gene

Domains & Families for CTTN Gene

Protein Domains for CTTN Gene

Graphical View of Domain Structure for InterPro Entry

Q14247

UniProtKB/Swiss-Prot:

SRC8_HUMAN :
  • The SH3 motif may mediate binding to the cytoskeleton.
  • Contains 7 cortactin repeats.
Domain:
  • The SH3 motif may mediate binding to the cytoskeleton.
  • Contains 1 SH3 domain.
Similarity:
  • Contains 7 cortactin repeats.
genes like me logo Genes that share domains with CTTN: view

No data available for Gene Families for CTTN Gene

Function for CTTN Gene

Molecular function for CTTN Gene

UniProtKB/Swiss-Prot Function:
Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).
genes like me logo Genes that share phenotypes with CTTN: view

Animal Models for CTTN Gene

MGI Knock Outs for CTTN:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTTN Gene

Localization for CTTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTTN Gene

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, dendrite. Cell projection. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome. Cell junction. Cell junction, focal adhesion. Membrane, clathrin-coated pit. Cell projection, dendritic spine. Cytoplasm, cell cortex. Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity). {ECO:0000250 UniProtKB:Q60598, ECO:0000250 UniProtKB:Q66HL2}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTTN Gene COMPARTMENTS Subcellular localization image for CTTN gene
Compartment Confidence
cytoskeleton 5
extracellular 5
golgi apparatus 5
plasma membrane 5
cytosol 4
endosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CTTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,ISS --
GO:0005884 colocalizes_with actin filament IDA 12151401
GO:0005905 coated pit ISS --
GO:0005925 focal adhesion IDA 21423176
GO:0005938 cell cortex IEA,ISS --
genes like me logo Genes that share ontologies with CTTN: view

Pathways & Interactions for CTTN Gene

genes like me logo Genes that share pathways with CTTN: view

SIGNOR curated interactions for CTTN Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CTTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA,IMP 17959782
GO:0006898 receptor-mediated endocytosis ISS --
GO:0006930 substrate-dependent cell migration, cell extension IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0030838 positive regulation of actin filament polymerization ISS --
genes like me logo Genes that share ontologies with CTTN: view

Drugs & Compounds for CTTN Gene

(10) Drugs for CTTN Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(14) Additional Compounds for CTTN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTTN: view

Transcripts for CTTN Gene

Unigene Clusters for CTTN Gene

Cortactin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTTN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ·
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: - -
SP7:
SP8:

ExUns: 18c · 18d ^ 19 ^ 20
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for CTTN Gene

GeneLoc Exon Structure for
CTTN
ECgene alternative splicing isoforms for
CTTN

Expression for CTTN Gene

mRNA expression in normal human tissues for CTTN Gene

Protein differential expression in normal tissues from HIPED for CTTN Gene

This gene is overexpressed in Nasal epithelium (13.1), Bone marrow stromal cell (11.0), and Platelet (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTTN Gene



SOURCE GeneReport for Unigene cluster for CTTN Gene Hs.596164

genes like me logo Genes that share expression patterns with CTTN: view

Protein tissue co-expression partners for CTTN Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CTTN Gene

Orthologs for CTTN Gene

This gene was present in the common ancestor of animals.

Orthologs for CTTN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTTN 35
  • 85.44 (n)
  • 90.52 (a)
CTTN 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTTN 35
  • 87.36 (n)
  • 92.57 (a)
CTTN 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cttn 35
  • 86.2 (n)
  • 92.86 (a)
Cttn 16
Cttn 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTTN 35
  • 95.21 (n)
  • 94.53 (a)
rat
(Rattus norvegicus)
Mammalia Cttn 35
  • 85.85 (n)
  • 91.94 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CTTN 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTTN 35
  • 77.78 (n)
  • 85.43 (a)
CTTN 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTTN 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cttn 35
  • 71.92 (n)
  • 74.11 (a)
Str.1561 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6493 35
zebrafish
(Danio rerio)
Actinopterygii cttn 35
  • 70.72 (n)
  • 73.51 (a)
zgc66325 35
cttn 36
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004625 35
  • 55.23 (n)
  • 53.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cortactin 35
  • 53.56 (n)
  • 47.78 (a)
Cortactin 36
  • 42 (a)
OneToMany
Species with no ortholog for CTTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTTN Gene

ENSEMBL:
Gene Tree for CTTN (if available)
TreeFam:
Gene Tree for CTTN (if available)

Paralogs for CTTN Gene

Paralogs for CTTN Gene

(4) SIMAP similar genes for CTTN Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CTTN: view

Variants for CTTN Gene

Sequence variations from dbSNP and Humsavar for CTTN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs548687 -- 70,429,793(-) TGTCA(A/G)TGGCA intron-variant
rs569732 -- 70,407,480(+) CACAA(C/T)CCAGG intron-variant
rs588871 -- 70,424,496(-) ATGTA(C/T)GGGGA intron-variant
rs592501 -- 70,423,671(+) CTGGG(G/T)GGGAC intron-variant
rs611216 -- 70,429,668(-) GTGAG(C/T)GGGGC intron-variant

Variation tolerance for CTTN Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTTN Gene

HapMap Linkage Disequilibrium report
CTTN
Human Gene Mutation Database (HGMD)
CTTN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CTTN Gene

Disorders for CTTN Gene

MalaCards: The human disease database

(9) MalaCards diseases for CTTN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ampulla of vater adenocarcinoma
  • adenocarcinoma of ampulla of vater
ethmoid sinus cancer
  • malignant neoplasm of ethmoidal sinus
ethmoid sinus adenocarcinoma
  • adenocarcinoma of ethmoid sinus
shigellosis
  • bacillary dysentery
salivary gland adenoid cystic carcinoma
  • adenoid cystic cancer
- elite association - COSMIC cancer census association via MalaCards
Search CTTN in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTTN

Genetic Association Database (GAD)
CTTN
Human Genome Epidemiology (HuGE) Navigator
CTTN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTTN
genes like me logo Genes that share disorders with CTTN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTTN Gene

Publications for CTTN Gene

  1. Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. (PMID: 16636290) Hashimoto S. … Sabe H. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23 67
  2. Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression. (PMID: 19898426) Xu X.Z. … Wu H. (Mod. Pathol. 2010) 3 23
  3. Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon. (PMID: 18931703) Clark E.S. … Weaver A.M. (Oncogene 2009) 3 23
  4. Expression of survivin and cortactin in colorectal adenocarcinoma: association with clinicopathological parameters. (PMID: 19242064) Lee Y.Y. … Jin J.S. (Dis. Markers 2009) 3 23
  5. Cortactin is a functional target of E-cadherin-activated Src family kinases in MCF7 epithelial monolayers. (PMID: 19457864) Ren G. … Yap A.S. (J. Biol. Chem. 2009) 3 23

Products for CTTN Gene

Sources for CTTN Gene

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