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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CTTN Gene

protein-coding GIFtS: 63
GCID: GC11P070244

cortactin

(Previous name: ems1 sequence (mammary tumor and squamous cell carcinoma-associated...)
(Previous symbol: EMS1)

Explore 41 diseases affiliated with
CTTN via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cortactin¹		1110020L01Rik²
EMS1¹ ² ³ ⁵		Amplaxin³
Ems1 Sequence (Mammary Tumor And Squamous Cell Carcinoma-Associated (P80/85 Src Substrate)¹ ²		Src Substrate Cortactin²
Oncogene EMS1² ³		Amplaxin³

External Ids:	HGNC: 3338¹	Entrez Gene: 2017²	Ensembl: ENSG00000085733⁷	OMIM: 164765⁵	UniProtKB: Q14247³

Export aliases for CTTN gene to outside databases

Previous GC identifers: GC11P069971 GC11P069922 GC11P066505

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTTN:

This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is

localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the

interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion

structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent

manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants

that encode different isoforms have been identified for this gene. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247

Function: Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation

of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases

Gene Wiki entry for CTTN (Cortactin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CTTN gene promoter:
HFH-3 AML1a FOXJ2 (long isoform) POU6F1 (c2) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CTTN promoter sequence

Search SABiosciences Chromatin IP Primers for CTTN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTTN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.3 HGNC cytogenetic band: 11q13

CTTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTTN gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P070244: view genomic region (about GC identifiers)

Start:	70,244,510 bp from pter	End:	70,282,690 bp from pter
Size:	38,181 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247 (See protein sequence)

Recommended Name: Src substrate cortactin

Size: 550 amino acids; 61586 Da

Subunit: Interacts with SHANK2 and SHANK3 (via its SH3 domain). Also interacts with FGD1. Identified in a complex

containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with ABL2 (By similarity). Interacts

with PLXDC2 and SRCIN1. Interacts with SAMSN1 (via SH3 domain). Interacts (via SH3 domain) with ASAP1 (via Pro-rich

region). Interacts with DNM2 and FER. Binds to MYLK. A complex made of ABL1, CTTN and MYLK regulates cortical

actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC)

barrier enhancement

Subcellular location: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Note=Associated

with membrane ruffles and lamellipodia

2 PDB 3D structures from and Proteopedia for CTTN:

1X69 (3D)

2D1X (3D)

Secondary accessions: Q8N707 Q96H99

Alternative splicing: 3 isoforms: Q14247-1 Q14247-2 Q14247-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CTTN: NX_Q14247

Post-translational modifications:

Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced

astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By similarity). Phosphorylated

by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.

Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14247

CTTN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001171669.1 NP_005222.2 NP_612632.1

ENSEMBL proteins:

ENSP00000317189 ENSP00000301843 ENSP00000365745 ENSP00000409014 ENSP00000433552

ENSP00000434669 ENSP00000377348 ENSP00000431421 ENSP00000436613 ENSP00000439762

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CTTN OriGene Protein Over-expression Lysate (see all 3): CTTN OriGene Custom Protein Services for CTTN
	GenScript Custom Purified and Recombinant Proteins Services for CTTN
	Novus Biologicals CTTN Proteins Novus Biologicals CTTN Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CTTN

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001726	ruffle	ISS	--
GO:0005625	soluble fraction	--	--
GO:0005737	cytoplasm	ISS	--
GO:0005856	cytoskeleton	IEA	--
GO:0005938	cell cortex	ISS	--

CTTN for ontologies About GeneDecksing

CTTN Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CTTN
	R&D Systems Antibodies for CTTN (Cortactin)
	Cell Signaling Technology (CST) Antibodies for CTTN (cortactin)
	OriGene Antibodies (see all 3): CTTN OriGene Custom Antibody Services for CTTN
	GenScript Custom Superior Antibodies Services for CTTN
	Novus Biologicals CTTN Antibodies
	Abcam antibodies for CTTN
	Uscn Antibodies for CTTN
	ThermoFisher Antibody for CTTN

Assay Products for CTTN:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CTTN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CTTN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CTTN for domains About GeneDecksing

4 InterPro domains/families:

IPR003134 Hs1_Cortactin

IPR015503 Cortactin

IPR000108 p67phox

IPR001452 SH3_domain

Graphical View of Domain Structure for InterPro Entry Q14247

ProtoNet protein and cluster: Q14247

2 Blocks protein families:

IPB001452 SH3 domain signature

IPB003134 Hs1/Cortactin

UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247

Domain: The SH3 motif may mediate binding to the cytoskeleton

Similarity: Contains 7 cortactin repeats

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247

Function: Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation

of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CTTN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTTN
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CTTN (see all 14):
		hsa-miR-3163 hsa-miR-142-3p hsa-miR-187* hsa-miR-1271 hsa-miR-548v hsa-miR-545 hsa-miR-20b* hsa-miR-182

		SwitchGear 3'UTR luciferase reporter plasmid: CTTN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTTN (see all 7) OriGene shRNA RFP: CTTN OriGene siRNA: CTTN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTTN

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CTTN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTTN (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTTN (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CTTN (NM_138565)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTTN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTTN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CTTN
		Search LifeMap BioReagents cell lines for CTTN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTTN

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	19146815

CTTN for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for CTTN: Cttn^tm1.2Okab Cttn^tm1.2Dvst
     8 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cttn):

cardiovascular system	cellular	embryogenesis	immune system	mortality/aging
no phenotypic analysis	reproductive system	respiratory system

CTTN for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeleton remodeling Slit-Robo signaling

	Cytoskeleton remodeling Slit-Robo signaling	1.00			Cell adhesion_Cadherin-mediated cell adhesion	0.28
	Development_Slit-Robo signaling	0.92			Cell adhesion Cadherin-mediated cell adhesion	0.28

Neurophysiological process Receptor-mediated axon growth repulsion

Neurophysiological process Receptor-mediated axon growth repulsion

1.00

Neurophysiological process_Receptor-mediated axon growth repulsion

0.94

Pathogenic Escherichia coli infection

Pathogenic Escherichia coli infection

1.00

Pathogenic Escherichia coli infection

0.98

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

E-cadherin signaling in the nascent adherens junction

E-cadherin signaling in the nascent adherens junction

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CTTN

	Neurophysiological process Receptor-mediated axon growth repulsion
	Cytoskeleton remodeling Slit-Robo signaling
	Cell adhesion Cadherin-mediated cell adhesion

1 Cell Signaling Technology (CST) Pathway for CTTN

Cytoskeletal Signaling

3 GeneGo (Thomson Reuters) Pathways for CTTN

	Neurophysiological process Receptor-mediated axon growth repulsion
	Development Slit-Robo signaling
	Cell adhesion Cadherin-mediated cell adhesion

5 BioSystems Pathways for CTTN

	Pathogenic Escherichia coli infection
	FGF signaling pathway
	N-cadherin signaling events
	E-cadherin signaling in the nascent adherens junction
	Syndecan-3-mediated signaling events

4 Kegg Pathways (Kegg details for CTTN):

	Tight junction
	Bacterial invasion of epithelial cells
	Pathogenic Escherichia coli infection
	Shigellosis

CTTN for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CTTN

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/662 Interacting proteins for CTTN (Q14247^{1, 2, 3} ENSP00000301843⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 662)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PAK1	Q13153²^,³, ENSP00000278568⁴	MINT-7945693 MINT-6541935 I2D: score=2 STRING: ENSP00000278568
MTSS1	O43312²^,³, ENSP00000322804⁴	MINT-7306884 I2D: score=2 STRING: ENSP00000322804
YWHAB	P31946²^,³, ENSP00000300161⁴	MINT-8009879 I2D: score=1 STRING: ENSP00000300161
CHD3	Q12873²^,³	MINT-7945693 I2D: score=3
ASAP1	Q9ULH1²^,³, ENSP00000350297⁴	MINT-7145534 MINT-7145594 MINT-7145426 MINT-7145630 MINT-7145519 MINT-7145575 I2D: score=1 STRING: ENSP00000350297

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CTTN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CTTN
10/24 Novoseek chemical compound relationships for CTTN gene (see all 24) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ucs15a	77.8	1	16636290 (1)
tyrosine	72.7	221	9748248 (5), 10952984 (5), 17420251 (5), 12851885 (5) (see all 90)
cytochalasin d	55.5	4	7545676 (1), 10072547 (1), 15671060 (1)
jasplakinolide	38.1	2	15030313 (1)
phosphotyrosine	33.8	4	16442522 (2), 18240308 (1)
threonine	32.2	6	16109479 (2), 9683637 (1), 15169891 (1), 18768925 (1) (see all 5)
pip2	20.4	1	17217950 (1)
serine	18.3	10	18768925 (4), 16109479 (2), 9683637 (1), 15169891 (1) (see all 6)
matrigel	17.6	1	15242766 (1)
thromboxane a2	15.7	2	10438543 (2)

Search CenterWatch for drugs/clinical trials and news about CTTN / SRC8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CTTN gene (3 alternative transcripts):

NM_001184740.1 NM_005231.3 NM_138565.2

Unigene Cluster for CTTN:

Cortactin

Hs.596164 [show with all ESTs]

Unigene Representative Sequence: NM_005231

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000346329(uc010rqm.2 uc001opu.3 uc001opw.4 uc001opx.3)

ENST00000301843(uc001opv.4) ENST00000482755 ENST00000527622 ENST00000376561

ENST00000415461 ENST00000525276 ENST00000532334 ENST00000527962 ENST00000483662

ENST00000498223 ENST00000525852 ENST00000393747 ENST00000529736 ENST00000533931

ENST00000538675

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CTTN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTTN
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CTTN (see all 14):
		hsa-miR-3163 hsa-miR-142-3p hsa-miR-187* hsa-miR-1271 hsa-miR-548v hsa-miR-545 hsa-miR-20b* hsa-miR-182

		SwitchGear 3'UTR luciferase reporter plasmid: CTTN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTTN (see all 7) OriGene shRNA RFP: CTTN OriGene siRNA: CTTN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTTN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTTN (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTTN (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CTTN (NM_138565)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTTN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTTN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTTN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CTTN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTTN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTTN

Additional cDNA sequence:

AK091778.1 AK222613.1 AK291097.1 AK304582.1 BC008799.2 BC033889.1 M98343.1

24/31 DOTS entries (see all 31):

DT.91882382 DT.447076 DT.100818545 DT.100818541 DT.91771079 DT.95183963 DT.91899683 DT.91976081

DT.92070660 DT.100030904 DT.100754041 DT.99960412 DT.120746422 DT.91771082 DT.92415497 DT.120746195

DT.120746431 DT.75105205 DT.91743354 DT.91993609 DT.87018110 DT.91866291 DT.92025209 DT.95170878

24/220 AceView cDNA sequences (see all 220):

AI338797 AW819667 AA845427 CA431395 BE816632 BE891493 BU541128 AW170308

AA908467 T27704 AW467072 BF434407 CB110275 BM459048 BF061580 AW006471

AW166140 CD107269 AW001339 BE465802 BQ941445 CB109016 CB106419 CA389488

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CTTN (see all 8) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	^	15	^	16a	·	16b	^	17a	·	17b	^	18a	·	18b	·
SP1:									-												-				-		-																-		-						-
SP2:									-												-						-																-		-
SP3:									-												-				-		-																-		-
SP4:																																											-		-
SP5:																																											-

ExUns:	18c	·	18d	^	19	^	20
SP1:	-		-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CTTN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CTTN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCAATTTCA

About this image

CTTN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CTTN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTTN

SOURCE GeneReport for Unigene cluster: Hs.596164

SABiosciences Expression via Pathway-Focused PCR Arrays including CTTN:

Cytoskeleton Regulators in human mouse rat

Tight Junctions in human mouse rat

Cell Motility in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTTN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CTTN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTTN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTTN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTTN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CTTN gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CTTN¹	cortactin	76.82(n) 84.18(a)		396455 NM_205468.1 NP_990799.1
lizard (Anolis carolinensis)	Reptilia	CTTN⁶	--	72(a)	1 ↔ 1	GL343283.1(199331-229248)
African clawed frog (Xenopus laevis)	Amphibia	Xl.6493²	Xenopus laevis mRNA for cortactin, complete cds	79.03(n)		AB027611.1
zebrafish (Danio rerio)	Actinopterygii	zgc66325²	similar to cortactin	77.75(n)		394016 BC055600.1
fruit fly (Drosophila melanogaster)	Insecta	Cortactin⁶	Cortactin	40(a)	1 → many	3R(16887402-16890193)

ENSEMBL Gene Tree for CTTN (if available)
TreeFam Gene Tree for CTTN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CTTN gene

DBN1² DBNL² HCLS1²

4 SIMAP similar genes for CTTN using alignment to 8 protein entries: SRC8_HUMAN (see all proteins):

EMS1 HCLS1 SH3GL2 DBNL

CTTN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111879164^1,2	C,	--	66504210(+)	`TTTTTT/ATTTTT`	3	--	us2k¹		2		CSA WA	120
rs11601536^1,2	H	--	66504265(+)	`cctcaG/Tcctcc`	3	--	us2k¹		0	--	--	--	--
rs78887322^1,2	C	--	66504371(-)	`GCCTGG/AGCAAC`	3	--	us2k¹		2		NA	4
rs12284785^1,2		--	66504782(+)	`ctcatT/Cacaat`	3	--	us2k¹		2		CSA WA	120
rs7938866^1,2	C,F,	--	66504927(+)	`attacA/Gggcgt`	3	--	us2k¹		1		WA	118
rs12576561^1,2	C,F,H,	--	66505502(+)	`ACGGCT/CGAGGG`	3	--	us2k¹		12		NS EA NA WA CSA	721
rs34612166^1,2		--	66505599(+)	`CCGGCC/TCCGGG`	3	--	us2k¹		5		CSA WA NA EA	361
rs11825736^1,2	C,A,H,	--	66505855(+)	`CCTGGC/TGCCTG`	3	--	ut5¹ ese³		0	--	--	--	--
rs34733714^1,2	C,F,	--	66506245(+)	`TGAGGG/AGAGGG`	3	--	int¹		7		WA NA CSA	246
rs79843900^1,2	F	--	66506684(+)	`GCGCAG/TGGAAA`	3	--	int¹		1		NA	4

HapMap Linkage Disequilibrium report for CTTN (70244510 - 70282690 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CTTN: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CTTN for disorders           About GeneDecksing

OMIM gene information: 164765    OMIM disorders: --

20/41 diseases for CTTN (see all 41):    About MalaCards

squamous cell carcinoma squamous cell carcinoma of the head and neck carcinoma aarskog-scott syndrome

breast cancer wiskott-aldrich syndrome ethmoid sinusitis ethmoid sinus adenocarcinoma

urinary bladder cancer adenoid cystic carcinoma oral squamous cell carcinoma peptic ulcer

scott syndrome esophageal squamous cell carcinoma polycystic kidney disease breast squamous cell carcinoma

sporadic breast cancer sinusitis laryngeal carcinoma adenoiditis

1 disease from the University of Copenhagen DISEASES database for CTTN:

Carcinoma

10/23 Novoseek disease relationships for CTTN gene (see all 23) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hnscc	65	40	16912177 (6), 17909038 (3), 18931703 (3), 17483334 (3) (see all 9)
carcinoma squamous cell	58.5	34	10955801 (3), 19125793 (2), 17909038 (2), 18607838 (2) (see all 20)
wiskott-aldrich syndrome	51.5	3	12517700 (1), 15585574 (1), 15579908 (1)
metastasis	45.7	56	15464244 (5), 17178864 (4), 16636290 (3), 18575752 (3) (see all 25)
laryngeal carcinoma	43.9	10	19947248 (7), 18268491 (3)
carcinoma	42.8	43	16280034 (3), 16912177 (3), 9054437 (3), 18776588 (2) (see all 20)
tumors	41	120	19125793 (4), 16912177 (4), 19898426 (4), 18607838 (4) (see all 48)
breast cancer	34.4	41	9747885 (6), 16636290 (3), 9380415 (3), 8945620 (3) (see all 17)
cancer	32.5	41	19885549 (7), 16261345 (3), 18403644 (3), 18406052 (2) (see all 18)
mammary tumor	29	5	16536875 (1), 9309140 (1), 18334127 (1), 9533029 (1)

Human Genome Epidemiology (HuGE) Navigator: CTTN (2 documents)

Export disorders for CTTN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CTTN gene, integrated from 9 sources (see all 414):
(articles sorted by number of sources associating them with CTTN)

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Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. (PubMed id 16636290)^{1, 2, 9} Hashimoto S....Sabe H. (2006)
Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. (PubMed id 15574754)^{1, 2, 9} Nanda A.... St Croix B. (2004)
Novel interaction of cortactin with endothelial cell myosin light chain kinase. (PubMed id 12408982)^{1, 2, 9} Dudek S.M....Garcia J.G. (2002)
The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell- substratum contact sites. (PubMed id 8474448)^{1, 2, 9} Schuuring E.M.D.... Michalides R.J.A. (1993)
Amplified region of chromosome band 11q13 in breast and squamous cell carcinomas encompasses three CpG islands telomeric of FGF3, including the expressed gene EMS1. (PubMed id 7685625)^{1, 3, 9} Brookes S....Peters G. (1993)
Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. (PubMed id 1532244)^{1, 2, 9} Schuuring E.M.D.... Michalides R.J.A. (1992)
Dynamic microtubules regulate dendritic spine morphol ogy and synaptic plasticity. (PubMed id 19146815)^{1, 2} Jaworski J....Hoogenraad C.C. (2009)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2017	HGNC: 3338	AceView: CTTN	Ensembl:ENSG00000085733	euGenes: HUgn2017
ECgene: CTTN	Kegg: 2017	H-InvDB: CTTN

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CTTN	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CTTN	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Cortactin

Intellectual Property for CTTN gene
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Patent Information for CTTN gene:
Search GeneIP for patents involving CTTN

GeneCards and IP:
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