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CTTN Gene

protein-coding   GIFtS: 64
GCID: GC11P070244

Cortactin

(Previous name: ems1 sequence (mammary tumor and squamous cell carcinoma-associated...)
(Previous symbol: EMS1)
  See CTTN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
cortactin1 2     1110020L01Rik2
EMS11 2 3 5     amplaxin2
Ems1 Sequence (Mammary Tumor And Squamous Cell Carcinoma-Associated
(P80/85 Src Substrate)1 2
     Src Substrate Cortactin2
Oncogene EMS12 3     Amplaxin3

External Ids:    HGNC: 33381   Entrez Gene: 20172   Ensembl: ENSG000000857337   OMIM: 1647655   UniProtKB: Q142473   

Export aliases for CTTN gene to outside databases

Previous GC identifers: GC11P069971 GC11P069922 GC11P066505


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTTN Gene:
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein
is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1)
regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and
cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a
caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis.
Three splice variants that encode different isoforms have been identified for this gene. (provided by RefSeq, May
2010)

GeneCards Summary for CTTN Gene:
CTTN (cortactin) is a protein-coding gene. Diseases associated with CTTN include ethmoid sinus adenocarcinoma, and ampulla of vater adenocarcinoma. An important paralog of this gene is DBN1.

UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247
Function: Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and
MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated
endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the
invasiveness of cancer cells, and the formation of metastases

Gene Wiki entry for CTTN (Cortactin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTTN gene promoter:
         HFH-3   AML1a   FOXJ2 (long isoform)   POU6F1 (c2)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTTN promoter sequence
   Search Chromatin IP Primers for CTTN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.3   HGNC cytogenetic band: 11q13

CTTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTTN gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P070244:  view genomic region     (about GC identifiers)

Start:
70,244,510 bp from pter      End:
70,282,690 bp from pter
Size:
38,181 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247 (See protein sequence)
Recommended Name: Src substrate cortactin  
Size: 550 amino acids; 61586 Da
Subunit: Interacts with SHANK2 and SHANK3 (via its SH3 domain). Also interacts with FGD1. Identified in a complex
containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with ABL2 (By similarity).
Interacts with PLXDC2 and SRCIN1. Interacts with SAMSN1 (via SH3 domain). Interacts (via SH3 domain) with ASAP1
(via Pro-rich region). Interacts with DNM2 and FER. Forms a complex made of ABL1 and MYLK. Interacts with
CTTNBP2NL; this interaction may target CTTN to stress fibers. Interacts with CTTNBP2; this interaction may target
CTTN at the cell cortex or dendritic spines
2 PDB 3D structures from and Proteopedia for CTTN:
1X69 (3D)        2D1X (3D)    
Secondary accessions: Q8N707 Q96H99
Alternative splicing: 3 isoforms:  Q14247-1   Q14247-2   Q14247-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CTTN: NX_Q14247

Explore proteomics data for CTTN at MOPED

Post-translational modifications: 

  • Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in
    hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By
    similarity). Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular
    growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC
    promotes MYLK binding1
  • Ubiquitination2 at Lys87, Lys124, Lys161, Lys171, Lys181, Lys208, Lys235, Lys272
  • Modification sites at PhosphoSitePlus

  • See CTTN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171669.1  NP_005222.2  NP_612632.1  

    ENSEMBL proteins: 
     ENSP00000317189   ENSP00000301843   ENSP00000365745   ENSP00000409014   ENSP00000433552  
     ENSP00000434669   ENSP00000377348   ENSP00000431421   ENSP00000436613   ENSP00000439762  

    CTTN Human Recombinant Protein Products:

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    OriGene Purified Protein for CTTN
    OriGene Protein Over-expression Lysate for CTTN
    OriGene MassSpec for CTTN
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    GenScript Custom Purified and Recombinant Proteins Services for CTTN
    Novus Biologicals CTTN Proteins
    Novus Biologicals CTTN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTTN

     
    Search eBioscience for Proteins for CTTN 

    CTTN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CTTN
    R&D Systems Antibodies for CTTN (Cortactin)
    Cell Signaling Technology (CST) Antibodies for CTTN  (cortactin)
    OriGene Antibodies for CTTN
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    Novus Biologicals CTTN Antibodies
    Abcam antibodies for CTTN
    Cloud-Clone Corp. Antibodies for CTTN
    ThermoFisher Antibody for CTTN
    LSBio Antibodies in human, mouse, rat for CTTN

    CTTN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CTTN
    Cloud-Clone Corp. CLIAs for CTTN
    Search eBioscience for ELISAs for CTTN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR003134 Hs1_Cortactin
     IPR015503 Cortactin
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q14247

    ProtoNet protein and cluster: Q14247

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB003134 Hs1/Cortactin


    UniProtKB/Swiss-Prot: SRC8_HUMAN, Q14247
    Domain: The SH3 motif may mediate binding to the cytoskeleton
    Similarity: Contains 7 cortactin repeats
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with CTTN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRC8_HUMAN, Q14247
    Function: Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and
    MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated
    endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the
    invasiveness of cancer cells, and the formation of metastases

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15169891
         
    Find genes that share ontologies with CTTN           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cttn):
     cardiovascular system  cellular  embryogenesis  hematopoietic system  immune system 
     mortality/aging  no phenotypic analysis  reproductive system  respiratory system 

    Find genes that share phenotypes with CTTN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CTTN: Cttntm1.2Okab Cttntm1.2Dvst

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTTN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTTN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTTN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTTN

    miRNA
    Products:
        
    miRTarBase miRNAs that target CTTN:
    hsa-mir-92a-3p (MIRT049499), hsa-mir-1 (MIRT023872), hsa-mir-34a-5p (MIRT025473), hsa-mir-340-5p (MIRT019566), hsa-mir-185-5p (MIRT045376)

    Block miRNA regulation of human, mouse, rat CTTN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTTN (see all 14):
    hsa-miR-3163 hsa-miR-142-3p hsa-miR-187* hsa-miR-1271 hsa-miR-548v hsa-miR-545 hsa-miR-20b* hsa-miR-182
    SwitchGear 3'UTR luciferase reporter plasmidCTTN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CTTN

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CTTN

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CTTN (NM_138565)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTTN
    Addgene plasmids for CTTN 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTTN

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12107) for CTTN 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRC8_HUMAN, Q14247: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell
    projection, dendrite (By similarity). Cell projection, dendritic spine (By similarity). Note=Associated with
    membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity).
    In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by
    glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    plasma membrane2
    endosome1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle ISS--
    GO:0005737cytoplasm ISS--
    GO:0005856cytoskeleton IEA--
    GO:0005938cell cortex ISS--
    GO:0030027lamellipodium ISS--

    Find genes that share ontologies with CTTN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTTN About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Salmonella infection (KEGG)
    Shigellosis0.30
    3Tight junction
    Tight junction
    4Syndecan-3-mediated signaling events
    Syndecan-3-mediated signaling events
    5Proteoglycans in cancer
    Proteoglycans in cancer


    Find genes that share SuperPaths with CTTN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CTTN
        Epithelial Tight Junctions
    Agrin Interactions at Neuromuscular Junction

    1 Cell Signaling Technology (CST) Pathway for CTTN
        Cytoskeletal Signaling

    3 GeneGo (Thomson Reuters) Pathways for CTTN
        Neurophysiological process Receptor-mediated axon growth repulsion
    Development Slit-Robo signaling
    Cell adhesion Cadherin-mediated cell adhesion

    5 BioSystems Pathways for CTTN
        Pathogenic Escherichia coli infection
    N-cadherin signaling events
    Syndecan-3-mediated signaling events
    E-cadherin signaling in the nascent adherens junction
    FGF signaling pathway


    5 Kegg Pathways  (Kegg details for CTTN):
        Tight junction
    Bacterial invasion of epithelial cells
    Pathogenic Escherichia coli infection
    Shigellosis
    Proteoglycans in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTTN: 
              Cytoskeleton Regulators in human mouse rat
              Tight Junctions in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CTTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTTN (Q142471, 2, 3 ENSP000003018434) via UniProtKB, MINT, STRING, and/or I2D (see all 740)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAK1Q131532, 3, ENSP000002785684MINT-7945693 MINT-6541935 I2D: score=2 STRING: ENSP00000278568
    MTSS1O433122, 3, ENSP000003228044MINT-7306884 I2D: score=2 STRING: ENSP00000322804
    HDAC6Q9UBN71, 3, ENSP000003340614EBI-351886,EBI-301697 I2D: score=1 STRING: ENSP00000334061
    YWHABP319462, 3, ENSP000003001614MINT-8009879 I2D: score=1 STRING: ENSP00000300161
    CHD3Q128732, 3MINT-7945693 I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTTN (SRC8)

    Selected Novoseek inferred chemical compound relationships for CTTN gene (see all 24)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ucs15a 77.8 1 16636290 (1)
    tyrosine 72.7 221 9748248 (5), 10952984 (5), 17420251 (5), 12851885 (5) (see all 90)
    cytochalasin d 55.5 4 7545676 (1), 10072547 (1), 15671060 (1)
    jasplakinolide 38.1 2 15030313 (1)
    phosphotyrosine 33.8 4 16442522 (2), 18240308 (1)
    threonine 32.2 6 16109479 (2), 9683637 (1), 15169891 (1), 18768925 (1) (see all 5)
    pip2 20.4 1 17217950 (1)
    serine 18.3 10 18768925 (4), 16109479 (2), 9683637 (1), 15169891 (1) (see all 6)
    matrigel 17.6 1 15242766 (1)
    thromboxane a2 15.7 2 10438543 (2)



    Find genes that share compounds with CTTN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTTN gene (3 alternative transcripts): 
    NM_001184740.1  NM_005231.3  NM_138565.2  

    Unigene Cluster for CTTN:

    Cortactin
    Hs.596164  [show with all ESTs]
    Unigene Representative Sequence: NM_005231
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346329(uc010rqm.2 uc001opu.3 uc001opw.4 uc001opx.3)
    ENST00000301843(uc001opv.4) ENST00000482755 ENST00000527622 ENST00000376561
    ENST00000415461 ENST00000525276 ENST00000532334 ENST00000527962 ENST00000483662
    ENST00000498223 ENST00000525852 ENST00000393747 ENST00000529736 ENST00000533931
    ENST00000538675
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CTTN (see all 14):
    hsa-miR-3163 hsa-miR-142-3p hsa-miR-187* hsa-miR-1271 hsa-miR-548v hsa-miR-545 hsa-miR-20b* hsa-miR-182
    SwitchGear 3'UTR luciferase reporter plasmidCTTN 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): CTTN (NM_138565)
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    Addgene plasmids for CTTN 
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    Flow Cytometry
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    Additional mRNA sequence: 

    AK091778.1 AK222613.1 AK291097.1 AK304582.1 BC008799.2 BC033889.1 M98343.1 

    Selected DOTS entries (see all 31):

    DT.91882382  DT.447076  DT.100818545  DT.100818541  DT.91771079  DT.95183963  DT.91899683  DT.91976081 
    DT.92070660  DT.100030904  DT.100754041  DT.99960412  DT.120746422  DT.91771082  DT.92415497  DT.120746195 
    DT.120746431  DT.75105205  DT.91743354  DT.91993609  DT.87018110  DT.91866291  DT.92025209  DT.95170878 

    Selected AceView cDNA sequences (see all 220):

    BQ961429 CR600359 CB106419 BM989953 AW166140 AA576139 BQ070136 BQ941445 
    AA845427 BF434407 BQ647254 CB130168 BM839381 AI146717 BM993684 CD107269 
    AI127977 AA113075 AI206566 AI949360 AL706115 AA789012 BM708644 AW819667 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CTTN (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ·
    SP1:                          -                                   -           -     -                                               -     -                 -   
    SP2:                          -                                   -                 -                                               -     -                     
    SP3:                          -                                   -           -     -                                               -     -                     
    SP4:                                                                                                                                -     -                     
    SP5:                                                                                                                                -                           

    ExUns: 18c · 18d ^ 19 ^ 20
    SP1:  -     -               
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CTTN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTTN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAATTTCA
    CTTN Expression
    About this image


    CTTN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    CTTN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTTN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.596164
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTTN: 
              Cytoskeleton Regulators in human mouse rat
              Tight Junctions in human mouse rat
              Cell Motility in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CTTN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cttn1 , 5 cortactin1, 5 86.2(n)1
    92.86(a)1
      7 (88.84 cM)5
    130431  NM_007803.51  NP_031829.21 
     1444357335 
    chicken
    (Gallus gallus)
    Aves CTTN1 cortactin 77.78(n)
    85.43(a)
      396455  NM_205468.1  NP_990799.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTTN6
    cortactin
    73(a)
    1 ↔ 1
    GL343283.1(199331-232974)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.64932 Xenopus laevis mRNA for cortactin, complete cds 79.03(n)    AB027611.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc663252 similar to cortactin 77.75(n)   394016  BC055600.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cortactin1 Cortactin 53.56(n)
    47.78(a)
      42491  NM_001260293.2  NP_001247222.1 


    ENSEMBL Gene Tree for CTTN (if available)
    TreeFam Gene Tree for CTTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTTN gene
    DBN12  HCLS12  DBNL2  
    4 SIMAP similar genes for CTTN using alignment to 8 protein entries:     SRC8_HUMAN (see all proteins):
    EMS1    HCLS1    SH3GL2    DBNL

    Find genes that share paralogs with CTTN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTTN (see all 1012)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1886056291,2
    --70087672(+) CACGTC/GCCTGT 3 -- us2k10--------
    rs1813938331,2
    --70087673(+) ACGTGA/CCTGTA 3 -- us2k10--------
    rs1486523471,2
    C--70087806(+) CAAAC-/AAAAAA 3 -- us2k10--------
    rs1869685091,2
    --70087860(+) ATGGGA/GTCTAT 3 -- us2k10--------
    rs1458373691,2
    --70087904(+) AGCAAA/TCCTCT 3 -- us2k10--------
    rs1118791641,2
    C,F--70088066(+) TTTTTT/ATTTTT 3 -- us2k12Minor allele frequency- A:0.10CSA WA 120
    rs116015361,2
    H--70088121(+) cctcaG/Tcctcc 3 -- us2k10--------
    rs1498873741,2
    C--70088188(+) AAAAA-/TTTTTT 3 -- us2k10--------
    rs788873221,2
    C--70088227(-) GCCTGG/AGCAAC 3 -- us2k12Minor allele frequency- A:0.00NA 4
    rs345523781,2
    C,F--70088262(+) CAATCC/TTCCTG 3 -- us2k18Minor allele frequency- T:0.12NA WA CSA EA 251

    HapMap Linkage Disequilibrium report for CTTN (70244510 - 70282690 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CTTN: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTTN
    DNA2.0 Custom Variant and Variant Library Synthesis for CTTN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164765    OMIM disorders: --

    3 diseases for CTTN:    
    About MalaCards
    ethmoid sinus adenocarcinoma    ampulla of vater adenocarcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CTTN:
    Carcinoma

    Find genes that share disorders with CTTN           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CTTN gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hnscc 65 40 16912177 (6), 17909038 (3), 18931703 (3), 17483334 (3) (see all 9)
    carcinoma squamous cell 58.5 34 10955801 (3), 19125793 (2), 17909038 (2), 18607838 (2) (see all 20)
    wiskott-aldrich syndrome 51.5 3 12517700 (1), 15585574 (1), 15579908 (1)
    metastasis 45.7 56 15464244 (5), 17178864 (4), 16636290 (3), 18575752 (3) (see all 25)
    laryngeal carcinoma 43.9 10 19947248 (7), 18268491 (3)
    carcinoma 42.8 43 16280034 (3), 16912177 (3), 9054437 (3), 18776588 (2) (see all 20)
    tumors 41 120 19125793 (4), 16912177 (4), 19898426 (4), 18607838 (4) (see all 48)
    breast cancer 34.4 41 9747885 (6), 16636290 (3), 9380415 (3), 8945620 (3) (see all 17)
    cancer 32.5 41 19885549 (7), 16261345 (3), 18403644 (3), 18406052 (2) (see all 18)
    mammary tumor 29 5 16536875 (1), 9309140 (1), 18334127 (1), 9533029 (1)

    Genetic Association Database (GAD): CTTN
    Human Genome Epidemiology (HuGE) Navigator: CTTN (2 documents)

    Export disorders for CTTN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTTN gene, integrated from 10 sources (see all 428):
    (articles sorted by number of sources associating them with CTTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. (PubMed id 16636290)1, 2, 9 Hashimoto S.... Sabe H. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    2. A common cortactin gene variation confers differential susceptibility to severe asthma. (PubMed id 18521921)1, 4, 9 Ma S.F....Garcia J.G. (Genet. Epidemiol. 2008)
    3. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. (PubMed id 15574754)1, 2, 9 Nanda A.... St Croix B. (Cancer Res. 2004)
    4. Novel interaction of cortactin with endothelial cell myosin light chain kinase. (PubMed id 12408982)1, 2, 9 Dudek S.M.... Garcia J.G.N. (Biochem. Biophys. Res. Commun. 2002)
    5. The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell- substratum contact sites. (PubMed id 8474448)1, 2, 9 Schuuring E.M.D.... Michalides R.J.A. (Mol. Cell. Biol. 1993)
    6. Amplified region of chromosome band 11q13 in breast and squamous cell carcinomas encompasses three CpG islands telomeric of FGF3, including the expressed gene EMS1. (PubMed id 7685625)1, 3, 9 Brookes S....Peters G. (amp 1993)
    7. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. (PubMed id 1532244)1, 2, 9 Schuuring E.M.D.... Michalides R.J.A. (Oncogene 1992)
    8. Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. (PubMed id 19146815)1, 2 Jaworski J.... Hoogenraad C.C. (Neuron 2009)
    9. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2017 HGNC: 3338 AceView: CTTN Ensembl:ENSG00000085733 euGenes: HUgn2017
    ECgene: CTTN Kegg: 2017 H-InvDB: CTTN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTTN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTTN Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Cortactin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTTN gene:
    Search GeneIP for patents involving CTTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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