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Aliases for CTTN Gene

Aliases for CTTN Gene

  • Cortactin 2 3
  • EMS1 3 4 6
  • Ems1 Sequence (Mammary Tumor And Squamous Cell Carcinoma-Associated (P80/85 Src Substrate) 2 3
  • Oncogene EMS1 3 4
  • Amplaxin 3 4
  • Src Substrate Cortactin 3
  • 1110020L01Rik 3

External Ids for CTTN Gene

Previous Symbols for CTTN Gene

  • EMS1

Summaries for CTTN Gene

Entrez Gene Summary for CTTN Gene

  • This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for CTTN Gene

CTTN (Cortactin) is a Protein Coding gene. Diseases associated with CTTN include breast cancer and ampulla of vater adenocarcinoma. Among its related pathways are Proteoglycans in cancer and N-cadherin signaling events. An important paralog of this gene is DBN1.

UniProtKB/Swiss-Prot for CTTN Gene

  • Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).

Gene Wiki entry for CTTN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTTN Gene

Genomics for CTTN Gene

Genomic Location for CTTN Gene

Start:
70,398,404 bp from pter
End:
70,436,584 bp from pter
Size:
38,181 bases
Orientation:
Plus strand

Genomic View for CTTN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTTN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTTN Gene

Regulatory Elements for CTTN Gene

Proteins for CTTN Gene

  • Protein details for CTTN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14247-SRC8_HUMAN
    Recommended name:
    Src substrate cortactin
    Protein Accession:
    Q14247
    Secondary Accessions:
    • Q8N707
    • Q96H99

    Protein attributes for CTTN Gene

    Size:
    550 amino acids
    Molecular mass:
    61586 Da
    Quaternary structure:
    • Interacts with SHANK2 and SHANK3 (via its SH3 domain). Also interacts with FGD1. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with ABL2 (By similarity). Interacts with KCNA2 (via non-phosphorylated C-terminus) (PubMed:12151401). Interacts with PLXDC2 and SRCIN1. Interacts with SAMSN1 (via SH3 domain). Interacts (via SH3 domain) with ASAP1 (via Pro-rich region). Interacts (via SH3 domain) with DNM2 (By similarity). Interacts with ACTN1 (By similarity). Interacts with FER (PubMed:9722593). Forms a complex made of ABL1 and MYLK. Interacts with CTTNBP2NL; this interaction may target CTTN to stress fibers. Interacts with CTTNBP2; this interaction may target CTTN at the cell cortex or dendritic spines. Interacts with KCNH1 (PubMed:23144454).

    Three dimensional structures from OCA and Proteopedia for CTTN Gene

    Alternative splice isoforms for CTTN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTTN Gene

Proteomics data for CTTN Gene at MOPED

Post-translational modifications for CTTN Gene

  • Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associates with filamentous actin (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (By similarity). Phosphorylated by PTK2/FAK1 in response to cell adhesion (By similarity). Phosphorylated by FER. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated in response to FGR activation. Phosphorylation by SRC promotes MYLK binding.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys87, Lys124, Lys161, Lys171, Lys181, Lys208, Lys235, and Lys272

No data available for DME Specific Peptides for CTTN Gene

Domains for CTTN Gene

Protein Domains for CTTN Gene

UniProtKB/Swiss-Prot:

SRC8_HUMAN
Domain:
  • The SH3 motif may mediate binding to the cytoskeleton.:
    • Q14247
  • Contains 1 SH3 domain.:
    • Q14247
Similarity:
  • Contains 7 cortactin repeats.:
    • Q14247
genes like me logo Genes that share domains with CTTN: view

No data available for Gene Families for CTTN Gene

Function for CTTN Gene

Molecular function for CTTN Gene

UniProtKB/Swiss-Prot Function: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879). Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (PubMed:20861316). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454).

Gene Ontology (GO) - Molecular Function for CTTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15169891
GO:0005522 profilin binding IPI 24700464
genes like me logo Genes that share ontologies with CTTN: view
genes like me logo Genes that share phenotypes with CTTN: view

Animal Models for CTTN Gene

MGI Knock Outs for CTTN:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CTTN Gene

Localization for CTTN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTTN Gene

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, dendrite. Cell projection. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome. Cell junction. Cell junction, focal adhesion. Membrane, clathrin-coated pit. Cell projection, dendritic spine. Cytoplasm, cell cortex. Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity). {ECO:0000250 UniProtKB:Q60598, ECO:0000250 UniProtKB:Q66HL2}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTTN Gene COMPARTMENTS Subcellular localization image for CTTN gene
Compartment Confidence
cytoskeleton 5
cytosol 3
plasma membrane 2
endosome 1
extracellular 1

Gene Ontology (GO) - Cellular Components for CTTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle ISS --
GO:0002102 podosome IEA --
GO:0005737 cytoplasm ISS --
GO:0005856 cytoskeleton TAS 9054437
GO:0005884 colocalizes_with actin filament IDA 12151401
genes like me logo Genes that share ontologies with CTTN: view

Pathways for CTTN Gene

genes like me logo Genes that share pathways with CTTN: view

Gene Ontology (GO) - Biological Process for CTTN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IMP 17959782
GO:0006898 receptor-mediated endocytosis ISS --
GO:0006930 substrate-dependent cell migration, cell extension IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0030041 actin filament polymerization IEA --
genes like me logo Genes that share ontologies with CTTN: view

Compounds for CTTN Gene

(24) Novoseek inferred chemical compound relationships for CTTN Gene

Compound -log(P) Hits PubMed IDs
ucs15a 77.8 1
tyrosine 72.7 175
cytochalasin d 55.5 3
jasplakinolide 38.1 1
phosphotyrosine 33.8 3
genes like me logo Genes that share compounds with CTTN: view

Transcripts for CTTN Gene

Unigene Clusters for CTTN Gene

Cortactin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTTN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b ·
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: - -
SP7:
SP8:

ExUns: 18c · 18d ^ 19 ^ 20
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for CTTN Gene

GeneLoc Exon Structure for
CTTN
ECgene alternative splicing isoforms for
CTTN

Expression for CTTN Gene

mRNA expression in normal human tissues for CTTN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTTN Gene

SOURCE GeneReport for Unigene cluster for CTTN Gene Hs.596164

genes like me logo Genes that share expressions with CTTN: view

Orthologs for CTTN Gene

This gene was present in the common ancestor of animals.

Orthologs for CTTN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTTN 36
  • 95.21 (n)
  • 94.53 (a)
cow
(Bos Taurus)
Mammalia CTTN 36
  • 85.44 (n)
  • 90.52 (a)
CTTN 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTTN 36
  • 87.36 (n)
  • 92.57 (a)
CTTN 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cttn 36
  • 86.2 (n)
  • 92.86 (a)
Cttn 16
Cttn 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTTN 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cttn 36
  • 85.85 (n)
  • 91.94 (a)
chicken
(Gallus gallus)
Aves CTTN 36
  • 77.78 (n)
  • 85.43 (a)
CTTN 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTTN 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6493 36
tropical clawed frog
(Silurana tropicalis)
Amphibia cttn 36
  • 71.92 (n)
  • 74.11 (a)
Str.1561 36
zebrafish
(Danio rerio)
Actinopterygii cttn 36
  • 70.72 (n)
  • 73.51 (a)
cttn 37
  • 64 (a)
OneToOne
zgc66325 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004625 36
  • 55.23 (n)
  • 53.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cortactin 36
  • 53.56 (n)
  • 47.78 (a)
Cortactin 37
  • 42 (a)
OneToMany
Species with no ortholog for CTTN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTTN Gene

ENSEMBL:
Gene Tree for CTTN (if available)
TreeFam:
Gene Tree for CTTN (if available)

Paralogs for CTTN Gene

Paralogs for CTTN Gene

Selected SIMAP similar genes for CTTN Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CTTN: view

Variants for CTTN Gene

Sequence variations from dbSNP and Humsavar for CTTN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs6894 -- 70,436,523(-) ACCTA(G/T)GAGGT utr-variant-3-prime
rs12858 -- 70,435,506(+) CCCTC(A/G)TGCCC missense, reference, utr-variant-3-prime
rs482438 -- 70,432,459(-) CACCG(G/T)CAGTG intron-variant
rs513487 -- 70,408,784(+) ACTCC(A/G)GTGGC intron-variant
rs548687 -- 70,429,793(-) TGTCA(A/G)TGGCA intron-variant

Relevant External Links for CTTN Gene

HapMap Linkage Disequilibrium report
CTTN

No data available for Structural Variations from Database of Genomic Variants (DGV) for CTTN Gene

Disorders for CTTN Gene

(1) University of Copenhagen DISEASES for CTTN Gene

(23) Novoseek inferred disease relationships for CTTN Gene

Disease -log(P) Hits PubMed IDs
hnscc 65 24
carcinoma squamous cell 58.5 25
wiskott-aldrich syndrome 51.5 3
metastasis 45.7 44
laryngeal carcinoma 43.9 10

Relevant External Links for CTTN

Genetic Association Database (GAD)
CTTN
Human Genome Epidemiology (HuGE) Navigator
CTTN
genes like me logo Genes that share disorders with CTTN: view

No data available for UniProtKB/Swiss-Prot for CTTN Gene

Publications for CTTN Gene

  1. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. (PMID: 1532244) Schuuring E.M.D. … Michalides R.J.A. (Oncogene 1992) 3 4 23
  2. Amplified region of chromosome band 11q13 in breast and squamous cell carcinomas encompasses three CpG islands telomeric of FGF3, including the expressed gene EMS1. (PMID: 7685625) Brookes S. … Peters G. (Genes Chromosomes Cancer 1993) 2 3 23
  3. The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell- substratum contact sites. (PMID: 8474448) Schuuring E.M.D. … Michalides R.J.A. (Mol. Cell. Biol. 1993) 3 4 23
  4. Novel interaction of cortactin with endothelial cell myosin light chain kinase. (PMID: 12408982) Dudek S.M. … Garcia J.G.N. (Biochem. Biophys. Res. Commun. 2002) 3 4 23
  5. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. (PMID: 15574754) Nanda A. … St Croix B. (Cancer Res. 2004) 3 4 23

Products for CTTN Gene

  • Addgene plasmids for CTTN

Sources for CTTN Gene

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