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CTSZ Gene

protein-coding   GIFtS: 65
GCID: GC20M057570

Cathepsin Z

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cathepsin Z1 2     Cysteine-Type Carboxypeptidase1 2
Cathepsin X1 2 3     Lysosomal Carboxypeptidase B1 2
Carboxypeptidase LB1 2     Cathepsin P2 3
Cathepsin B21 2     EC 3.4.18.13 8
Cathepsin IV1 2     CTSX2
Cathepsin Y1 2     Preprocathepsin P2
Cathepsin Z11 2     

External Ids:    HGNC: 25471   Entrez Gene: 15222   Ensembl: ENSG000001011607   OMIM: 6031695   UniProtKB: Q9UBR23   

Export aliases for CTSZ gene to outside databases

Previous GC identifers: GC20M057298 GC20M058208 GC20M058255 GC20M057003 GC20M054357


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTSZ Gene:
The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It
exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known
as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and,
like other members of this family, may be involved in tumorigenesis. (provided by RefSeq, Oct 2008)

GeneCards Summary for CTSZ Gene:
CTSZ (cathepsin Z) is a protein-coding gene. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is CTSF.

UniProtKB/Swiss-Prot: CATZ_HUMAN, Q9UBR2
Function: Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity

Gene Wiki entry for CTSZ (Cathepsin Z) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTSZ gene promoter:
         SRF   C/EBPbeta   Pax-6   SRF (504 AA)   YY1   C/EBPalpha   En-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTSZ promoter sequence
   Search Chromatin IP Primers for CTSZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTSZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.32   Ensembl cytogenetic band:  20q13.32   HGNC cytogenetic band: 20q13.32

CTSZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSZ gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M057570:  view genomic region     (about GC identifiers)

Start:
57,570,240 bp from pter      End:
57,582,309 bp from pter
Size:
12,070 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CATZ_HUMAN, Q9UBR2 (See protein sequence)
Recommended Name: Cathepsin Z precursor  
Size: 303 amino acids; 33868 Da
2 PDB 3D structures from and Proteopedia for CTSZ:
1DEU (3D)        1EF7 (3D)    
Secondary accessions: B2RC40 O75331 Q9UQV5 Q9UQV6

Explore the universe of human proteins at neXtProt for CTSZ: NX_Q9UBR2

Explore proteomics data for CTSZ at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn184, Asn224
  • Selected DME Specific Peptides for CTSZ (Q9UBR2) (see all 5)
     RIVTSTYK  NGPISCGIMATE  EYWIVRNSWGEPWGE  TRNQHIPQYCGSCWAH 


    See CTSZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001327.2  
    ENSEMBL proteins: 
     ENSP00000217131  
    Reactome Protein details: Q9UBR2

    CTSZ Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CTSZ
    Sino Biological Cell Lysate for CTSZ
    ProSpec Recombinant Protein for CTSZ
    Cloud-Clone Corp. Proteins for CTSZ

     
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CTSZ
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    Search eBioscience for ELISAs for CTSZ 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CTS: Cathepsins

    3 InterPro protein domains:
     IPR013128 Peptidase_C1A
     IPR025661 Pept_asp_AS
     IPR000668 Peptidase_C1A_C

    Graphical View of Domain Structure for InterPro Entry Q9UBR2

    ProtoNet protein and cluster: Q9UBR2

    1 Blocks protein domain: IPB000668 Papain cysteine protease (C1) family signature

    UniProtKB/Swiss-Prot: CATZ_HUMAN, Q9UBR2
    Similarity: Belongs to the peptidase C1 family


    Find genes that share domains with CTSZ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATZ_HUMAN, Q9UBR2
    Function: Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity
    Catalytic activity: Release of C-terminal amino acid residues with broad specificity, but lacks action on
    C-terminal proline. Shows weak endopeptidase activity

         Genatlas biochemistry entry for CTSZ:
    cathepsin Z,cysteine proteinase,papain superfamily member,ubiquitously expressed,involved normal intracellular
    degradation

         Enzyme Number (IUBMB): EC 3.4.18.11 2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008234cysteine-type peptidase activity IEA--
         
    Find genes that share ontologies with CTSZ           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CTSZ:
     Increased cell death in breast 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ctsz):
     cellular  normal  renal/urinary system  tumorigenesis 

    Find genes that share phenotypes with CTSZ           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTSZ
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    miRNA
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    miRTarBase miRNAs that target CTSZ:
    hsa-mir-128-3p (MIRT021991), hsa-mir-505-3p (MIRT041024), hsa-mir-615-3p (MIRT039629), hsa-mir-26b-5p (MIRT029430)

    Block miRNA regulation of human, mouse, rat CTSZ using miScript Target Protectors
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    Sino Biological Human cDNA Clone for CTSZ
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSZ

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSZ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CATZ_HUMAN, Q9UBR2: Lysosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    vacuole5
    endoplasmic reticulum4
    extracellular4
    plasma membrane4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005764lysosome IEA--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane TAS--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with CTSZ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTSZ About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    Lysosome Vesicle Biogenesis0.41
    trans-Golgi Network Vesicle Budding0.89
    Membrane Trafficking0.32
    2Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Metabolism of Angiotensinogen to Angiotensins0.00
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Lysosome
    Lysosome


    Find genes that share SuperPaths with CTSZ           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for CTSZ
        Metabolism of Angiotensinogen to Angiotensins
    Lysosome Vesicle Biogenesis


    1 Kegg Pathway  (Kegg details for CTSZ):
        Lysosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTSZ
    Interactions:

        Search GeneGlobe Interaction Network for CTSZ

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for CTSZ (Q9UBR23 ENSP000002171314) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AMY2AP047463I2D: score=1 
    KRTAP5-9P263713I2D: score=1 
    ACE2ENSP000002525194STRING: ENSP00000252519
    ATP6AP2ENSP000003676974STRING: ENSP00000367697
    GOPCENSP000003574844STRING: ENSP00000357484
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002003angiotensin maturation TAS--
    GO:0006508proteolysis TAS9642240
    GO:0044267cellular protein metabolic process TAS--
    GO:0060441epithelial tube branching involved in lung morphogenesis IEA--

    Find genes that share ontologies with CTSZ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTSZ (CATZ)

    1 Novoseek inferred chemical compound relationship for CTSZ gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 55.9 10 9642240 (4), 10760573 (2), 10653162 (1), 17218008 (1) (see all 5)



    Find genes that share compounds with CTSZ           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTSZ gene: 
    NM_001336.3  

    Unigene Cluster for CTSZ:

    Cathepsin Z
    Hs.252549  [show with all ESTs]
    Unigene Representative Sequence: NM_001336
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000217131(uc002yai.2) ENST00000503833(uc002yaj.4) ENST00000488395
    ENST00000472025
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CTSZ
      QuantiFast Probe-based Assays in human, mouse, rat CTSZ

    Additional mRNA sequence: 

    AF009923.1 AF073890.1 AF136273.1 AK314931.1 BC025419.2 BC042168.1 BT019915.1 

    19 DOTS entries:

    DT.97759997  DT.448927  DT.95076513  DT.99933713  DT.120833594  DT.95261096  DT.95261097  DT.100783553 
    DT.87078881  DT.75176018  DT.91748864  DT.95261005  DT.120833540  DT.120833583  DT.91707044  DT.120833566 
    DT.121413598  DT.91777786  DT.95351331 

    Selected AceView cDNA sequences (see all 231):

    AI472198 AI073435 BM129317 CN485127 BE747230 AA912840 AI422113 BE501860 
    AI274264 BE501841 AI301323 AI377517 AI168099 BM837068 AI420441 BC042168 
    AW009155 AI521288 CF131397 AI081224 AI377190 AI802976 AA789084 AI363372 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTSZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTGCCTC
    CTSZ Expression
    About this image


    CTSZ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    CTSZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTSZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.252549

    UniProtKB/Swiss-Prot: CATZ_HUMAN, Q9UBR2
    Tissue specificity: Widely expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CTSZ gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctsz1 , 5 cathepsin Z1, 5 83.92(n)1
    85.66(a)1
      2 (97.94 cM)5
    641381  NM_022325.41  NP_071720.11 
     1744274935 
    chicken
    (Gallus gallus)
    Aves CTSZ1 cathepsin Z 72.68(n)
    76.9(a)
      419311  XM_417483.4  XP_417483.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    72(a)
    64(a)
    (see all 4)
    1 ↔ many
    1 ↔ many
    (see all 4)
    GL343475.1(579853-603101)
    GL343475.1(560752-568412)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.85872 Xenopus laevis transcribed sequence with weak similarity more 78.23(n)    CB944759.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ctsz1 cathepsin Z 66.91(n)
    68.35(a)
      450022  NM_001006043.1  NP_001006043.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F32B5.83
    cpz-11
    cysteine proteinase3
    cpz-11
    62(a)
    (best of 2)3
    61.38(n)1
    62.6(a)1
      I(2686699-2691806)3
    1718291  NM_058622.51  NP_491023.21 


    ENSEMBL Gene Tree for CTSZ (if available)
    TreeFam Gene Tree for CTSZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTSZ gene
    CTSF2  CTSO2  CTSW2  CTSV2  CTSK2  CTSS2  CTSH2  CTSC2  
    CTSL2  

    Find genes that share paralogs with CTSZ           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTSZ (see all 378)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110866621,2
    C--54361483(+) ACCTTC/-CATCT 1 -- int12Minor allele frequency- -:0.00NA 4
    rs106273561,2
    C--54361529(+) GAGAA-/TTCTTTCT 1 -- cds10--------
    rs2003423371,2
    --54362046(+) AAAAA-/AAAAAC
            
    AAACT
    1 -- int10--------
    rs1132255811,2
    C--54362047(+) AAAAA-/AAAAC 
            
    AAACT
    1 -- int11Minor allele frequency- AAAAC:0.00CSA 2
    rs2000533691,2
    C--54362047(+) AAAAA-/AAAAC 
            
    AAACT
    1 -- int10--------
    rs2018880621,2
    --57539740(+) ATCCTC/TCAGAG 1 -- ds50010--------
    rs73411,2
    C,F,A,H--57539811(+) GGCTCG/TGGCAG 1 -- ds500124Minor allele frequency- T:0.41MN NS EA NA CSA WA 2667
    rs10432191,2
    C--57539855(+) GATGAC/GTTCTT 1 -- ds50015Minor allele frequency- G:0.10MN NA CSA EA 427
    rs1825594651,2
    --57539876(+) AATGGC/TAGCAG 1 -- ds50010--------
    rs1848888191,2
    --57539928(+) TGTCAA/GTCCAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CTSZ (57570240 - 57582309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CTSZ:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525118CNV Loss19592680
    nsv912963CNV Gain21882294

    Human Gene Mutation Database (HGMD): CTSZ
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing CTSZ:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing CTSZ
    DNA2.0 Custom Variant and Variant Library Synthesis for CTSZ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603169    OMIM disorders: --


    Find genes that share disorders with CTSZ           About GenesLikeMe

    1 Novoseek inferred disease relationship for CTSZ gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    protein deficiency 69.9 1 15849265 (1)

    Genetic Association Database (GAD): CTSZ
    Human Genome Epidemiology (HuGE) Navigator: CTSZ (4 documents)

    Export disorders for CTSZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTSZ gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with CTSZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. (PubMed id 9642240)1, 2, 3, 9 Santamaria I.... Lopez-Otin C. (J. Biol. Chem. 1998)
    2. Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization. (PubMed id 10760573)1, 2, 9 Deussing J.... Peters C. (Biochim. Biophys. Acta 2000)
    3. Identification and molecular cloning of cathepsin P, a novel human putative cysteine protease of the papain family. (PubMed id 10653162)1, 2, 9 Pungercar J. and Ivanovski G. (Pflugers Arch. 2000)
    4. Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis. (PubMed id 18420963)1, 4, 9 Cooke G.S....Hill A.V. (Am. J. Respir. Crit. Care Med. 2008)
    5. Tissue expression and immunolocalization of a novel human cathepsin P. (PubMed id 10653163)1, 2, 9 Pungercar J.... Krizaj I. (Pflugers Arch. 2000)
    6. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    7. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    10. Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease. (PubMed id 10745011)1, 2 Guncar G.... Turk D. (Structure 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1522 HGNC: 2547 AceView: CTSZ Ensembl:ENSG00000101160 euGenes: HUgn1522
    ECgene: CTSZ Kegg: 1522 H-InvDB: CTSZ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTSZ Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTSZ Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTSZ gene:
    Search GeneIP for patents involving CTSZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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