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Aliases for CTSZ Gene

Aliases for CTSZ Gene

  • Cathepsin Z 2 3 5
  • Cathepsin X 2 3 4
  • Cysteine-Type Carboxypeptidase 2 3
  • Lysosomal Carboxypeptidase B 2 3
  • Carboxypeptidase LB 2 3
  • Cathepsin IV 2 3
  • Cathepsin B2 2 3
  • Cathepsin Z1 2 3
  • Cathepsin Y 2 3
  • Cathepsin P 3 4
  • EC 4 61
  • Preprocathepsin P 3
  • CTSX 3

External Ids for CTSZ Gene

Previous GeneCards Identifiers for CTSZ Gene

  • GC20M057298
  • GC20M058208
  • GC20M058255
  • GC20M057003
  • GC20M057570
  • GC20M054357

Summaries for CTSZ Gene

Entrez Gene Summary for CTSZ Gene

  • The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]

GeneCards Summary for CTSZ Gene

CTSZ (Cathepsin Z) is a Protein Coding gene. Diseases associated with CTSZ include Dacryoadenitis. Among its related pathways are Transport to the Golgi and subsequent modification and Immune System. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is CTSC.

UniProtKB/Swiss-Prot for CTSZ Gene

  • Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.

Gene Wiki entry for CTSZ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSZ Gene

Genomics for CTSZ Gene

Regulatory Elements for CTSZ Gene

Enhancers for CTSZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F059003 0.2 ENCODE 13.8 +1.2 1203 6.1 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 SIN3A FEZF1 DMAP1 ZNF2 YY1 NELFCD LOC101927932 ENSG00000254419 CTSZ ATP5E GNAS ENSG00000270951 GC20M058985
GH20F058995 0.4 ENCODE 9.5 +11.1 11135 1.3 ELF3 MLX ARID4B RAD21 DNMT3B ZNF48 RARA YY1 SLC30A9 CREM ATP5E NELFCD CTSZ GC20M058985
GH20F059451 0.9 ENCODE 4.8 -445.8 -445815 3.6 CTCF YBX1 RAD21 ZIC2 ZKSCAN1 ARID3A ZNF316 CTBP1 ZNF366 ZNF207 ENSG00000254419 EDN3 CTSZ PIEZO1P1 ENSG00000230352
GH20F059002 0.7 ENCODE 0.8 +4.5 4454 0.2 ATF1 SAP130 RAD21 HBP1 YY1 TEAD3 RARA POLR2A HNF4G NR2F6 ATP5E NELFCD CTSZ GC20M058985
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CTSZ on UCSC Golden Path with GeneCards custom track

Promoters for CTSZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CTSZ Gene

58,995,185 bp from pter
59,007,254 bp from pter
12,070 bases
Minus strand

Genomic View for CTSZ Gene

Genes around CTSZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSZ Gene

Proteins for CTSZ Gene

  • Protein details for CTSZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathepsin Z
    Protein Accession:
    Secondary Accessions:
    • B2RC40
    • O75331
    • Q9UQV5
    • Q9UQV6

    Protein attributes for CTSZ Gene

    303 amino acids
    Molecular mass:
    33868 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTSZ Gene

neXtProt entry for CTSZ Gene

Selected DME Specific Peptides for CTSZ Gene


Post-translational modifications for CTSZ Gene

  • Glycosylation at Asn 184 and Asn 224
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSZ Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CTSZ (Cathepsin X/Z/P)

Domains & Families for CTSZ Gene

Gene Families for CTSZ Gene

Suggested Antigen Peptide Sequences for CTSZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C1 family.
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSZ: view

Function for CTSZ Gene

Molecular function for CTSZ Gene

GENATLAS Biochemistry:
cathepsin Z,cysteine proteinase,papain superfamily member,ubiquitously expressed,involved normal intracellular degradation
UniProtKB/Swiss-Prot CatalyticActivity:
Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.
UniProtKB/Swiss-Prot Function:
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.

Enzyme Numbers (IUBMB) for CTSZ Gene

Gene Ontology (GO) - Molecular Function for CTSZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0005515 protein binding IPI 21516116
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity TAS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CTSZ: view
genes like me logo Genes that share phenotypes with CTSZ: view

Animal Models for CTSZ Gene

MGI Knock Outs for CTSZ:

Animal Model Products

  • Taconic Biosciences Mouse Models for CTSZ

miRNA for CTSZ Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSZ Gene

Localization for CTSZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSZ Gene


Subcellular locations from

Jensen Localization Image for CTSZ Gene COMPARTMENTS Subcellular localization image for CTSZ gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
lysosome 5
plasma membrane 5
vacuole 5
golgi apparatus 4
endosome 1

Gene Ontology (GO) - Cellular Components for CTSZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005615 extracellular space IDA 20551380
GO:0005764 lysosome IEA,IBA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with CTSZ: view

Pathways & Interactions for CTSZ Gene

genes like me logo Genes that share pathways with CTSZ: view

Gene Ontology (GO) - Biological Process for CTSZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002003 angiotensin maturation TAS --
GO:0006508 proteolysis TAS 9642240
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0048208 COPII vesicle coating TAS --
GO:0051603 proteolysis involved in cellular protein catabolic process IBA --
genes like me logo Genes that share ontologies with CTSZ: view

No data available for SIGNOR curated interactions for CTSZ Gene

Drugs & Compounds for CTSZ Gene

(3) Drugs for CTSZ Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
E-64-c Pharma Inhibitor of cysteine proteinases 0
Odanacatib (MK-0822) Pharma Cathepsin K,potent and selective 0

(2) ApexBio Compounds for CTSZ Gene

Compound Action Cas Number
E-64-c Inhibitor of cysteine proteinases 76684-89-4
Odanacatib (MK-0822) Cathepsin K,potent and selective 603139-19-1
genes like me logo Genes that share compounds with CTSZ: view

Transcripts for CTSZ Gene

Unigene Clusters for CTSZ Gene

Cathepsin Z:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTSZ Gene

No ASD Table

Relevant External Links for CTSZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTSZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSZ Gene

This gene is overexpressed in Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for CTSZ Gene

This gene is overexpressed in Nasal epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTSZ Gene

NURSA nuclear receptor signaling pathways regulating expression of CTSZ Gene:


SOURCE GeneReport for Unigene cluster for CTSZ Gene:


mRNA Expression by UniProt/SwissProt for CTSZ Gene:

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with CTSZ: view

Primer Products

No data available for Protein tissue co-expression partners for CTSZ Gene

Orthologs for CTSZ Gene

This gene was present in the common ancestor of animals.

Orthologs for CTSZ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTSZ 34 35
  • 99.67 (n)
(Bos Taurus)
Mammalia CTSZ 34 35
  • 85.31 (n)
(Canis familiaris)
Mammalia CTSZ 34 35
  • 84.87 (n)
(Mus musculus)
Mammalia Ctsz 34 16 35
  • 83.92 (n)
(Rattus norvegicus)
Mammalia Ctsz 34
  • 83.33 (n)
(Monodelphis domestica)
Mammalia CTSZ 35
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia CTSZ 35
  • 68 (a)
(Gallus gallus)
Aves CTSZ 34 35
  • 72.68 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 72 (a)
-- 35
  • 64 (a)
-- 35
  • 61 (a)
-- 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctsz 34
  • 74.03 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8587 34
(Danio rerio)
Actinopterygii ctsz 34 35
  • 66.91 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1216 34
(Caenorhabditis elegans)
Secernentea F32B5.8 36
  • 62 (a)
cpz-1 34 35
  • 61.38 (n)
M04G12.2 36
  • 50 (a)
Species where no ortholog for CTSZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSZ Gene

Gene Tree for CTSZ (if available)
Gene Tree for CTSZ (if available)

Paralogs for CTSZ Gene

Paralogs for CTSZ Gene

genes like me logo Genes that share paralogs with CTSZ: view

Variants for CTSZ Gene

Sequence variations from dbSNP and Humsavar for CTSZ Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10369 -- 58,995,401(+) TGTGT(C/T)GCAGG downstream-variant-500B, utr-variant-3-prime
rs10427474 -- 59,000,302(+) aaacc(C/T)gggag intron-variant
rs1043219 -- 58,994,805(+) GATGA(C/G)TTCTT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs10582096 -- 58,997,184(+) AAAAA(-/A)TCTGG intron-variant
rs10627356 -- 58,999,559(+) GAGAA(-/TTC)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTSZ Gene

Variant ID Type Subtype PubMed ID
nsv525118 CNV loss 19592680
nsv955144 CNV deletion 24416366

Variation tolerance for CTSZ Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTSZ Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSZ Gene

Disorders for CTSZ Gene

MalaCards: The human disease database

(1) MalaCards diseases for CTSZ Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • dacryocystitis
- elite association - COSMIC cancer census association via MalaCards
Search CTSZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTSZ

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CTSZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSZ Gene

Publications for CTSZ Gene

  1. Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. (PMID: 9642240) Santamaria I. … Lopez-Otin C. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis. (PMID: 18420963) Cooke G.S. … Hill A.V. (Am. J. Respir. Crit. Care Med. 2008) 3 22 46 64
  3. Identification and molecular cloning of cathepsin P, a novel human putative cysteine protease of the papain family. (PMID: 10653162) Pungercar J. … Ivanovski G. (Pflugers Arch. 2000) 3 4 22 64
  4. Tissue expression and immunolocalization of a novel human cathepsin P. (PMID: 10653163) Pungercar J. … Krizaj I. (Pflugers Arch. 2000) 3 4 22 64
  5. Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization. (PMID: 10760573) Deussing J. … Peters C. (Biochim. Biophys. Acta 2000) 3 4 22 64

Products for CTSZ Gene

  • Cloud-Clone Corp. Antibodies for CTSZ
  • Cloud-Clone Corp. Proteins for CTSZ
  • Cloud-Clone Corp Assay Kits for CTSZ

Sources for CTSZ Gene

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