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Aliases for CTSZ Gene

Aliases for CTSZ Gene

  • Cathepsin Z 2 3
  • Cathepsin X 2 3 4
  • Cysteine-Type Carboxypeptidase 2 3
  • Lysosomal Carboxypeptidase B 2 3
  • Carboxypeptidase LB 2 3
  • Cathepsin IV 2 3
  • Cathepsin B2 2 3
  • Cathepsin Z1 2 3
  • Cathepsin Y 2 3
  • Cathepsin P 3 4
  • EC 4 63
  • Preprocathepsin P 3
  • CTSX 3

External Ids for CTSZ Gene

Previous GeneCards Identifiers for CTSZ Gene

  • GC20M057298
  • GC20M058208
  • GC20M058255
  • GC20M057003
  • GC20M057570
  • GC20M054357

Summaries for CTSZ Gene

Entrez Gene Summary for CTSZ Gene

  • The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]

GeneCards Summary for CTSZ Gene

CTSZ (Cathepsin Z) is a Protein Coding gene. Among its related pathways are Lysosome and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is CTSW.

UniProtKB/Swiss-Prot for CTSZ Gene

  • Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity

Gene Wiki entry for CTSZ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSZ Gene

Genomics for CTSZ Gene

Regulatory Elements for CTSZ Gene

Genomic Location for CTSZ Gene

58,995,185 bp from pter
59,007,254 bp from pter
12,070 bases
Minus strand

Genomic View for CTSZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTSZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSZ Gene

Proteins for CTSZ Gene

  • Protein details for CTSZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathepsin Z
    Protein Accession:
    Secondary Accessions:
    • B2RC40
    • O75331
    • Q9UQV5
    • Q9UQV6

    Protein attributes for CTSZ Gene

    303 amino acids
    Molecular mass:
    33868 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTSZ Gene

neXtProt entry for CTSZ Gene

Proteomics data for CTSZ Gene at MOPED

Selected DME Specific Peptides for CTSZ Gene

Post-translational modifications for CTSZ Gene

  • Glycosylation at Asn184 and Asn224

Other Protein References for CTSZ Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CTSZ (Cathepsin X/Z/P)

Domains for CTSZ Gene

Gene Families for CTSZ Gene

  • CTS :Cathepsins

Protein Domains for CTSZ Gene

Suggested Antigen Peptide Sequences for CTSZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UBR2
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSZ: view

Function for CTSZ Gene

Molecular function for CTSZ Gene

GENATLAS Biochemistry: cathepsin Z,cysteine proteinase,papain superfamily member,ubiquitously expressed,involved normal intracellular degradation
UniProtKB/Swiss-Prot CatalyticActivity: Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.
UniProtKB/Swiss-Prot Function: Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity

Enzyme Numbers (IUBMB) for CTSZ Gene

Gene Ontology (GO) - Molecular Function for CTSZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with CTSZ: view
genes like me logo Genes that share phenotypes with CTSZ: view

Animal Model Products

miRNA for CTSZ Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTSZ

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CTSZ Gene

Localization for CTSZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSZ Gene


Subcellular locations from

Jensen Localization Image for CTSZ Gene COMPARTMENTS Subcellular localization image for CTSZ gene
Compartment Confidence
lysosome 5
vacuole 5
endoplasmic reticulum 4
extracellular 4
plasma membrane 4

Gene Ontology (GO) - Cellular Components for CTSZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20551380
GO:0005764 lysosome IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CTSZ: view

Pathways for CTSZ Gene

genes like me logo Genes that share pathways with CTSZ: view

Pathways by source for CTSZ Gene

Gene Ontology (GO) - Biological Process for CTSZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002003 angiotensin maturation TAS --
GO:0006508 proteolysis TAS 9642240
GO:0044267 cellular protein metabolic process TAS --
GO:0060441 epithelial tube branching involved in lung morphogenesis IEA --
genes like me logo Genes that share ontologies with CTSZ: view

Compounds for CTSZ Gene

(1) Novoseek inferred chemical compound relationships for CTSZ Gene

Compound -log(P) Hits PubMed IDs
cysteine 55.9 9
genes like me logo Genes that share compounds with CTSZ: view

Transcripts for CTSZ Gene

mRNA/cDNA for CTSZ Gene

Unigene Clusters for CTSZ Gene

Cathepsin Z:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTSZ

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTSZ Gene

No ASD Table

Relevant External Links for CTSZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSZ Gene

mRNA expression in normal human tissues for CTSZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSZ Gene

This gene is overexpressed in Whole Blood (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTSZ Gene

SOURCE GeneReport for Unigene cluster for CTSZ Gene Hs.252549

mRNA Expression by UniProt/SwissProt for CTSZ Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with CTSZ: view

In Situ Assay Products

Orthologs for CTSZ Gene

This gene was present in the common ancestor of animals.

Orthologs for CTSZ Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTSZ 35
  • 99.67 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia CTSZ 35
  • 85.31 (n)
  • 86.01 (a)
  • 85 (a)
(Canis familiaris)
Mammalia CTSZ 35
  • 84.87 (n)
  • 88.08 (a)
  • 88 (a)
(Mus musculus)
Mammalia Ctsz 35
  • 83.92 (n)
  • 85.66 (a)
Ctsz 16
Ctsz 36
  • 82 (a)
(Monodelphis domestica)
Mammalia CTSZ 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia CTSZ 36
  • 68 (a)
(Rattus norvegicus)
Mammalia Ctsz 35
  • 83.33 (n)
  • 87.06 (a)
(Gallus gallus)
Aves CTSZ 35
  • 72.68 (n)
  • 76.9 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
-- 36
  • 72 (a)
-- 36
  • 60 (a)
-- 36
  • 61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8587 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ctsz 35
  • 74.03 (n)
  • 77.17 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1216 35
(Danio rerio)
Actinopterygii ctsz 35
  • 66.91 (n)
  • 68.35 (a)
ctsz 36
  • 64 (a)
(Caenorhabditis elegans)
Secernentea cpz-1 35
  • 61.38 (n)
  • 62.6 (a)
cpz-1 36
  • 55 (a)
M04G12.2 37
  • 50 (a)
F32B5.8 37
  • 62 (a)
Species with no ortholog for CTSZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSZ Gene

Gene Tree for CTSZ (if available)
Gene Tree for CTSZ (if available)

Paralogs for CTSZ Gene

Paralogs for CTSZ Gene

genes like me logo Genes that share paralogs with CTSZ: view

Variants for CTSZ Gene

Sequence variations from dbSNP and Humsavar for CTSZ Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs9760 -- 58,996,708(+) GCCAC(A/G)GAAAC synonymous-codon, reference
rs151335 -- 59,004,895(+) GTCCC(A/G)CATCC intron-variant
rs151343 -- 59,008,243(+) CTGTC(C/G)GAGTG upstream-variant-2KB
rs163785 -- 58,997,620(+) TTTGC(A/C/G)TAGAT reference, stop-gained, synonymous-codon
rs163786 -- 58,998,800(+) CACGG(C/T)GGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTSZ Gene

Variant ID Type Subtype PubMed ID
nsv912963 CNV Gain 21882294
nsv525118 CNV Loss 19592680

Relevant External Links for CTSZ Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

PCR Panel Products

  • Copy Number PCR Panels: for CTSZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSZ Gene

Disorders for CTSZ Gene

(1) Novoseek inferred disease relationships for CTSZ Gene

Disease -log(P) Hits PubMed IDs
protein deficiency 69.9 1

Relevant External Links for CTSZ

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CTSZ: view

No data available for UniProtKB/Swiss-Prot for CTSZ Gene

Publications for CTSZ Gene

  1. Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. (PMID: 9642240) Santamaria I. … Lopez-Otin C. (J. Biol. Chem. 1998) 2 3 4 23
  2. Identification and molecular cloning of cathepsin P, a novel human putative cysteine protease of the papain family. (PMID: 10653162) Pungercar J. … Ivanovski G. (Pflugers Arch. 2000) 3 4 23
  3. Tissue expression and immunolocalization of a novel human cathepsin P. (PMID: 10653163) Pungercar J. … Krizaj I. (Pflugers Arch. 2000) 3 4 23
  4. Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization. (PMID: 10760573) Deussing J. … Peters C. (Biochim. Biophys. Acta 2000) 3 4 23
  5. Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis. (PMID: 18420963) Cooke G.S. … Hill A.V. (Am. J. Respir. Crit. Care Med. 2008) 3 23 48

Products for CTSZ Gene

Sources for CTSZ Gene

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