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Aliases for CTSW Gene

Aliases for CTSW Gene

  • Cathepsin W 2 3 5
  • Lymphopain 3 4
  • Cathepsin W (Lymphopain) 2
  • EC 3.4.22.- 4
  • LYPN 3

External Ids for CTSW Gene

Previous GeneCards Identifiers for CTSW Gene

  • GC11P068181
  • GC11P067328
  • GC11P065897
  • GC11P065422
  • GC11P065405
  • GC11P065647
  • GC11P061973

Summaries for CTSW Gene

Entrez Gene Summary for CTSW Gene

  • The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTSW Gene

CTSW (Cathepsin W) is a Protein Coding gene. Diseases associated with CTSW include autoimmune atrophic gastritis. Among its related pathways are Apoptosis Modulation and Signaling and Lysosome. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is CTSO.

UniProtKB/Swiss-Prot for CTSW Gene

  • May have a specific function in the mechanism or regulation of T-cell cytolytic activity.

Gene Wiki entry for CTSW Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSW Gene

Genomics for CTSW Gene

Regulatory Elements for CTSW Gene

Enhancers for CTSW Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CTSW on UCSC Golden Path with GeneCards custom track

Genomic Location for CTSW Gene

Chromosome:
11
Start:
65,879,809 bp from pter
End:
65,883,741 bp from pter
Size:
3,933 bases
Orientation:
Plus strand

Genomic View for CTSW Gene

Genes around CTSW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSW Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSW Gene

Proteins for CTSW Gene

  • Protein details for CTSW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56202-CATW_HUMAN
    Recommended name:
    Cathepsin W
    Protein Accession:
    P56202
    Secondary Accessions:
    • Q86VT4

    Protein attributes for CTSW Gene

    Size:
    376 amino acids
    Molecular mass:
    42120 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTSW Gene

Proteomics data for CTSW Gene at MOPED

Post-translational modifications for CTSW Gene

  • Glycosylation at Asn 50 and Asn 205
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSW Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTSW Gene

Domains & Families for CTSW Gene

Gene Families for CTSW Gene

Suggested Antigen Peptide Sequences for CTSW Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56202

UniProtKB/Swiss-Prot:

CATW_HUMAN :
  • Belongs to the peptidase C1 family.
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSW: view

Function for CTSW Gene

Molecular function for CTSW Gene

GENATLAS Biochemistry:
cathepsin W,cysteine protease,papain superfamily,expressed in endoplasmic reticulum in CD8+ T-lymphocytes,subgroup F-like protease
UniProtKB/Swiss-Prot Function:
May have a specific function in the mechanism or regulation of T-cell cytolytic activity.

Enzyme Numbers (IUBMB) for CTSW Gene

genes like me logo Genes that share phenotypes with CTSW: view

Animal Models for CTSW Gene

MGI Knock Outs for CTSW:

Animal Model Products

miRNA for CTSW Gene

miRTarBase miRNAs that target CTSW

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSW Gene

Localization for CTSW Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTSW Gene COMPARTMENTS Subcellular localization image for CTSW gene
Compartment Confidence
extracellular 4
lysosome 4
vacuole 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CTSW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CTSW: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CTSW Gene

Pathways & Interactions for CTSW Gene

genes like me logo Genes that share pathways with CTSW: view

Pathways by source for CTSW Gene

2 KEGG pathways for CTSW Gene

Interacting Proteins for CTSW Gene

Gene Ontology (GO) - Biological Process for CTSW Gene

None

No data available for SIGNOR curated interactions for CTSW Gene

Drugs & Compounds for CTSW Gene

(4) Drugs for CTSW Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Papain Inhibitor Pharma Inhibitor of peptidase activity of Papain 0

(1) ApexBio Compounds for CTSW Gene

Compound Action Cas Number
Papain Inhibitor Inhibitor of peptidase activity of Papain 70195-20-9
genes like me logo Genes that share compounds with CTSW: view

Transcripts for CTSW Gene

mRNA/cDNA for CTSW Gene

Unigene Clusters for CTSW Gene

Cathepsin W:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTSW Gene

No ASD Table

Relevant External Links for CTSW Gene

GeneLoc Exon Structure for
CTSW
ECgene alternative splicing isoforms for
CTSW

Expression for CTSW Gene

mRNA expression in normal human tissues for CTSW Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSW Gene

This gene is overexpressed in Whole Blood (x39.9).

Protein differential expression in normal tissues from HIPED for CTSW Gene

This gene is overexpressed in NK cells (37.5), Peripheral blood mononuclear cells (20.6), and CD8 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTSW Gene



SOURCE GeneReport for Unigene cluster for CTSW Gene Hs.416848

mRNA Expression by UniProt/SwissProt for CTSW Gene

P56202-CATW_HUMAN
Tissue specificity: Expressed in natural killer and cytotoxic T cells.
genes like me logo Genes that share expression patterns with CTSW: view

Protein tissue co-expression partners for CTSW Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CTSW Gene

This gene was present in the common ancestor of animals.

Orthologs for CTSW Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CTSW 35
  • 81.19 (n)
  • 73.8 (a)
CTSW 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctsw 35
  • 75.56 (n)
  • 67.92 (a)
Ctsw 16
Ctsw 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTSW 35
  • 99.47 (n)
  • 98.94 (a)
CTSW 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctsw 35
  • 75.56 (n)
  • 69 (a)
cow
(Bos Taurus)
Mammalia CTSW 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTSW 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 37 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 17 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ctsw 35
  • 54.4 (n)
  • 48.83 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:110239 36
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12163 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R07E3.1 37
  • 29 (a)
R09F10.1 37
  • 33 (a)
tag-196 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2594 36
  • 39 (a)
OneToMany
Species with no ortholog for CTSW:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSW Gene

ENSEMBL:
Gene Tree for CTSW (if available)
TreeFam:
Gene Tree for CTSW (if available)

Paralogs for CTSW Gene

Paralogs for CTSW Gene

(8) SIMAP similar genes for CTSW Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTSW: view

Variants for CTSW Gene

Sequence variations from dbSNP and Humsavar for CTSW Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs606830 - 65,882,812(+) GTTCC(A/G)GGGCA reference, missense
rs604630 - 65,882,303(+) TGGCC(A/G/T)GCGCC reference, missense
rs596002 -- 65,877,883(+) GGTCA(A/G)GAGAT upstream-variant-2KB
rs601863 -- 65,879,086(+) ccggc(A/C)TGCTT upstream-variant-2KB
rs613457 -- 65,879,396(+) cctgt(A/T)atccc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CTSW Gene

Variant ID Type Subtype PubMed ID
nsv897736 CNV Loss 21882294
dgv393e1 CNV Complex 17122850
dgv1185n71 CNV Loss 21882294
nsv897764 CNV Loss 21882294
nsv832191 CNV Loss 17160897

Variation tolerance for CTSW Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTSW Gene

HapMap Linkage Disequilibrium report
CTSW

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSW Gene

Disorders for CTSW Gene

MalaCards: The human disease database

(1) MalaCards diseases for CTSW Gene - From: GeneCards

Disorder Aliases PubMed IDs
autoimmune atrophic gastritis
- elite association - COSMIC cancer census association via MalaCards
Search CTSW in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTSW

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTSW
genes like me logo Genes that share disorders with CTSW: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSW Gene

Publications for CTSW Gene

  1. Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. (PMID: 9108299) Linnevers C. … Broemme D. (FEBS Lett. 1997) 2 3 4 23 67
  2. Genomic structure, chromosomal localization, and expression of human cathepsin W. (PMID: 9675123) Wex T. … Bromme D. (Biochem. Biophys. Res. Commun. 1998) 2 3 23
  3. Cathepsin W expressed exclusively in CD8+ T cells and NK cells, is secreted during target cell killing but is not essential for cytotoxicity in human CTLs. (PMID: 19100676) Stoeckle C. … Tolosa E. (Exp. Hematol. 2009) 3 23
  4. Identification of a novel isoform predominantly expressed in gastric tissue and a triple-base pair polymorphism of the cathepsin W gene. (PMID: 15358123) Meinhardt C. … Wex T. (Biochem. Biophys. Res. Commun. 2004) 3 23
  5. Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal tract. (PMID: 12437118) Buhling F. … Wex T. (Biol. Chem. 2002) 3 23

Products for CTSW Gene

Sources for CTSW Gene

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