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Aliases for CTSW Gene

Aliases for CTSW Gene

  • Cathepsin W 2 3 5
  • Lymphopain 3 4
  • Cathepsin W (Lymphopain) 2
  • EC 3.4.22.- 4
  • LYPN 3

External Ids for CTSW Gene

Previous GeneCards Identifiers for CTSW Gene

  • GC11P068181
  • GC11P067328
  • GC11P065897
  • GC11P065422
  • GC11P065405
  • GC11P065647
  • GC11P061973

Summaries for CTSW Gene

Entrez Gene Summary for CTSW Gene

  • The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTSW Gene

CTSW (Cathepsin W) is a Protein Coding gene. Diseases associated with CTSW include Autoimmune Atrophic Gastritis. Among its related pathways are Lysosome and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is CTSF.

UniProtKB/Swiss-Prot for CTSW Gene

  • May have a specific function in the mechanism or regulation of T-cell cytolytic activity.

Gene Wiki entry for CTSW Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSW Gene

Genomics for CTSW Gene

Regulatory Elements for CTSW Gene

Enhancers for CTSW Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065878 0.5 Ensembl ENCODE 51.3 +0.1 121 3.7 CTCF MAX ZMYM3 SIN3A YY1 SREBF1 POLR2A KLF9 CTSW SNX32 FIBP
GH11F065884 0.5 ENCODE 51.1 +5.2 5226 1.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF207 ZNF143 CTSW KAT5 FIBP
GH11F065886 0.8 FANTOM5 ENCODE 51.1 +15.7 15650 18.4 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SNX32 CTSW MRPL11 EIF1AD NEAT1 MUS81 ENSG00000258297 KAT5 FAU POLA2
GH11F065868 1 ENCODE 39.5 -8.1 -8101 5.6 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A YBX1 SLC30A9 ZNF143 CTSW SNX32 EFEMP2 KRT8P26 PIR60009
GH11F065811 1.1 Ensembl ENCODE 27.9 -67.6 -67603 2.0 PKNOX1 NR2F1 ZNF223 CEBPB EBF1 BCL11B NCOR1 SMARCA4 POLR2A BCL11A SNX32 CTSW MAP3K11 OVOL1-AS1 OVOL1 AP5B1 CFL1 PCNX3 CCDC85B FIBP
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CTSW on UCSC Golden Path with GeneCards custom track

Genomic Location for CTSW Gene

Chromosome:
11
Start:
65,879,809 bp from pter
End:
65,883,741 bp from pter
Size:
3,933 bases
Orientation:
Plus strand

Genomic View for CTSW Gene

Genes around CTSW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSW Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSW Gene

Proteins for CTSW Gene

  • Protein details for CTSW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56202-CATW_HUMAN
    Recommended name:
    Cathepsin W
    Protein Accession:
    P56202
    Secondary Accessions:
    • Q86VT4

    Protein attributes for CTSW Gene

    Size:
    376 amino acids
    Molecular mass:
    42120 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTSW Gene

Post-translational modifications for CTSW Gene

  • Glycosylation at Asn 50 and Asn 205
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSW Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTSW Gene

Domains & Families for CTSW Gene

Gene Families for CTSW Gene

Suggested Antigen Peptide Sequences for CTSW Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56202

UniProtKB/Swiss-Prot:

CATW_HUMAN :
  • Belongs to the peptidase C1 family.
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSW: view

Function for CTSW Gene

Molecular function for CTSW Gene

GENATLAS Biochemistry:
cathepsin W,cysteine protease,papain superfamily,expressed in endoplasmic reticulum in CD8+ T-lymphocytes,subgroup F-like protease
UniProtKB/Swiss-Prot Function:
May have a specific function in the mechanism or regulation of T-cell cytolytic activity.

Enzyme Numbers (IUBMB) for CTSW Gene

Gene Ontology (GO) - Molecular Function for CTSW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IBA --
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA,TAS 9823953
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CTSW: view
genes like me logo Genes that share phenotypes with CTSW: view

Animal Models for CTSW Gene

MGI Knock Outs for CTSW:

Animal Model Products

miRNA for CTSW Gene

miRTarBase miRNAs that target CTSW

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSW Gene

Localization for CTSW Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTSW Gene COMPARTMENTS Subcellular localization image for CTSW gene
Compartment Confidence
extracellular 4
lysosome 4
vacuole 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CTSW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005764 lysosome IBA --
GO:0016020 membrane IDA 19946888
GO:0031089 platelet dense granule lumen TAS --
genes like me logo Genes that share ontologies with CTSW: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CTSW Gene

Pathways & Interactions for CTSW Gene

genes like me logo Genes that share pathways with CTSW: view

Pathways by source for CTSW Gene

2 KEGG pathways for CTSW Gene

Interacting Proteins for CTSW Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000311300%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000357484%0d%0a9606.ENSP00000261714%0d%0a9606.ENSP00000360129%0d%0a
Selected Interacting proteins: P56202-CATW_HUMAN ENSP00000311300 for CTSW Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for CTSW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006508 proteolysis IEA --
GO:0006955 immune response TAS 9823953
GO:0051603 proteolysis involved in cellular protein catabolic process IBA --
genes like me logo Genes that share ontologies with CTSW: view

No data available for SIGNOR curated interactions for CTSW Gene

Drugs & Compounds for CTSW Gene

(3) Drugs for CTSW Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Papain Inhibitor Pharma Inhibitor of peptidase activity of Papain 0

(1) Additional Compounds for CTSW Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CTSW Gene

Compound Action Cas Number
Papain Inhibitor Inhibitor of peptidase activity of Papain 70195-20-9
genes like me logo Genes that share compounds with CTSW: view

Transcripts for CTSW Gene

mRNA/cDNA for CTSW Gene

Unigene Clusters for CTSW Gene

Cathepsin W:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTSW Gene

No ASD Table

Relevant External Links for CTSW Gene

GeneLoc Exon Structure for
CTSW
ECgene alternative splicing isoforms for
CTSW

Expression for CTSW Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTSW Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSW Gene

This gene is overexpressed in Whole Blood (x39.9).

Protein differential expression in normal tissues from HIPED for CTSW Gene

This gene is overexpressed in NK cells (37.5), Peripheral blood mononuclear cells (20.6), and CD8 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTSW Gene



Protein tissue co-expression partners for CTSW Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTSW Gene:

CTSW

SOURCE GeneReport for Unigene cluster for CTSW Gene:

Hs.416848

mRNA Expression by UniProt/SwissProt for CTSW Gene:

P56202-CATW_HUMAN
Tissue specificity: Expressed in natural killer and cytotoxic T cells.
genes like me logo Genes that share expression patterns with CTSW: view

Primer Products

Orthologs for CTSW Gene

This gene was present in the common ancestor of animals.

Orthologs for CTSW Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTSW 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia CTSW 34 35
  • 81.19 (n)
mouse
(Mus musculus)
Mammalia Ctsw 34 16 35
  • 75.56 (n)
rat
(Rattus norvegicus)
Mammalia Ctsw 34
  • 75.56 (n)
cow
(Bos Taurus)
Mammalia CTSW 35
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTSW 35
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 48 (a)
OneToMany
-- 35
  • 48 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 17 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ctsw 34
  • 54.4 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:110239 35
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12163 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R09F10.1 36
  • 33 (a)
R07E3.1 36
  • 29 (a)
tag-196 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2594 35
  • 39 (a)
OneToMany
Species where no ortholog for CTSW was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSW Gene

ENSEMBL:
Gene Tree for CTSW (if available)
TreeFam:
Gene Tree for CTSW (if available)

Paralogs for CTSW Gene

Paralogs for CTSW Gene

(8) SIMAP similar genes for CTSW Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTSW: view

Variants for CTSW Gene

Sequence variations from dbSNP and Humsavar for CTSW Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111385621 -- 65,881,316(+) ACTGG(A/G)TGGGT intron-variant
rs111398658 -- 65,878,709(+) GGCTG(A/C/G)TCTCC upstream-variant-2KB
rs112825852 -- 65,879,639(+) AAAAA(A/C)AAAAG upstream-variant-2KB
rs113243481 -- 65,884,045(+) GTGTC(A/G/T)GTAAG downstream-variant-500B, splice-acceptor-variant
rs113492674 -- 65,882,486(+) CTGTG(A/G)CGCAT reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for CTSW Gene

Variant ID Type Subtype PubMed ID
esv2759834 CNV gain 17122850
nsv1159905 CNV duplication 26073780
nsv555215 CNV loss 21841781
nsv832191 CNV loss 17160897
nsv951019 CNV deletion 24416366

Variation tolerance for CTSW Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTSW Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTSW

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSW Gene

Disorders for CTSW Gene

MalaCards: The human disease database

(1) MalaCards diseases for CTSW Gene - From: GeneCards

Disorder Aliases PubMed IDs
autoimmune atrophic gastritis
- elite association - COSMIC cancer census association via MalaCards
Search CTSW in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTSW

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTSW
genes like me logo Genes that share disorders with CTSW: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSW Gene

Publications for CTSW Gene

  1. Genomic structure, chromosomal localization, and expression of human cathepsin W. (PMID: 9675123) Wex T. … Bromme D. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 22 64
  2. Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. (PMID: 9108299) Linnevers C. … Broemme D. (FEBS Lett. 1997) 2 3 4 22 64
  3. Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase. (PMID: 9823953) Brown J. … Enver T. (Leukemia 1998) 3 4 22 64
  4. Cathepsin W expressed exclusively in CD8+ T cells and NK cells, is secreted during target cell killing but is not essential for cytotoxicity in human CTLs. (PMID: 19100676) Stoeckle C. … Tolosa E. (Exp. Hematol. 2009) 3 22 64
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64

Products for CTSW Gene

Sources for CTSW Gene

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