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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTSW Gene

protein-coding   GIFtS: 60
GCID: GC11P065647

Cathepsin W

(Previous name: cathepsin W (lymphopain))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cathepsin W1 2
Cathepsin W (Lymphopain)1
LYPN2
lymphopain2
EC 3.4.22.-3
Lymphopain3

External Ids:    HGNC: 25461   Entrez Gene: 15212   Ensembl: ENSG000001725437   OMIM: 6023645   UniProtKB: P562023   

Export aliases for CTSW gene to outside databases

Previous GC identifers: GC11P068181 GC11P067328 GC11P065897 GC11P065422 GC11P065405 GC11P061973


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTSW Gene:
The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a
specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found
associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression
of this gene is up-regulated by interleukin-2. (provided by RefSeq, Jul 2008)

GeneCards Summary for CTSW Gene: 
CTSW (cathepsin W) is a protein-coding gene. Diseases associated with CTSW include autoimmune atrophic gastritis, and atrophic gastritis. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is TINAG.

UniProtKB/Swiss-Prot: CATW_HUMAN, P56202
Function: May have a specific function in the mechanism or regulation of T-cell cytolytic activity

Gene Wiki entry for CTSW (Cathepsin W) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTSW gene promoter:
         p53   ATF-2   Lmo2   IRF-1   Roaz   PPAR-alpha   FAC1   COMP1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTSW promoter sequence
   Search SABiosciences Chromatin IP Primers for CTSW

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSW


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

CTSW Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSW gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P065647:  view genomic region     (about GC identifiers)

Start:
65,647,280 bp from pter      End:
65,651,212 bp from pter
Size:
3,933 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CATW_HUMAN, P56202 (See protein sequence)
Recommended Name: Cathepsin W precursor  
Size: 376 amino acids; 42120 Da
Secondary accessions: Q86VT4

Explore the universe of human proteins at neXtProt for CTSW: NX_P56202

Explore proteomics data for CTSW at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P56202

  • CTSW Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CTSW Protein Expression
    REFSEQ proteins: NP_001326.2  
    ENSEMBL proteins: 
     ENSP00000311300   ENSP00000436568   ENSP00000434267  

    Human Recombinant Protein Products for CTSW: 
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    OriGene Protein Over-expression Lysate for CTSW
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CTSW
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    Novus Biologicals CTSW Protein
    Novus Biologicals CTSW Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTSW 


    CTSW Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CTSW Antibodies
    Abcam antibodies for CTSW
    Cloud-Clone Corp. Antibodies for CTSW 
    ThermoFisher Antibodies for CTSW
    LSBio Antibodies in human, mouse, rat for CTSW 

    Assay Products for CTSW: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CTSW 
    Cloud-Clone Corp. CLIAs for CTSW


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CTS: Cathepsins

    5 InterPro protein domains:
     IPR013128 Peptidase_C1A
     IPR025661 Pept_asp_AS
     IPR013201 Prot_inhib_I29
     IPR025660 Pept_his_AS
     IPR000668 Peptidase_C1A_C

    Graphical View of Domain Structure for InterPro Entry P56202

    ProtoNet protein and cluster: P56202

    2 Blocks protein domains:
    IPB000668 Papain cysteine protease (C1) family signature
    IPB013201 Proteinase inhibitor I29


    UniProtKB/Swiss-Prot: CATW_HUMAN, P56202
    Similarity: Belongs to the peptidase C1 family


    CTSW for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATW_HUMAN, P56202
    Function: May have a specific function in the mechanism or regulation of T-cell cytolytic activity

         Genatlas biochemistry entry for CTSW:
    cathepsin W,cysteine protease,papain superfamily,expressed in endoplasmic reticulum in CD8+ T-lymphocytes,subgroup
    F-like protease

         Enzyme Number (IUBMB): EC 3.4.22.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008234cysteine-type peptidase activity IEA--
         
    CTSW for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CTSW:
     Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ctsw):
     immune system  normal 

    CTSW for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ctswtm1Ctnp for CTSW

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CTSW 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTSW

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTSW 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTSW 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTSW
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CTSW
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CTSW
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CTSW

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CTSW (see all 8)
    OriGene ORF clones in mouse, rat for CTSW
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTSW (NM_001335)
    Sino Biological Human cDNA Clone for CTSW
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSW
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                         Customized lentivirus expression plasmids for stable overexpression of CTSW 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSW


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CTSW About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Lysosome
    Lysosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for CTSW):
        Lysosome


    CTSW for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTSW

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for CTSW (P562023 ENSP000003113004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    CSTBENSP000002915684STRING: ENSP00000291568
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0006955immune response TAS9823953

    CTSW for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CTSW for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTSW (CATW)

    3 Novoseek inferred chemical compound relationships for CTSW gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 64.9 19 10716634 (2), 9823953 (2), 11490002 (2), 15087452 (1) (see all 9)
    asparagine 43.1 1 9108299 (1)
    histidine 27.6 1 9108299 (1)

    Search CenterWatch for drugs/clinical trials and news about CTSW / CATW

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CTSW gene: 
    NM_001335.3  

    Unigene Cluster for CTSW:

    Cathepsin W
    Hs.416848  [show with all ESTs]
    Unigene Representative Sequence: BC048255
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307886(uc001ogc.1) ENST00000524681 ENST00000528419 ENST00000526034

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTSW
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CTSW
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CTSW
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSW
    Clone
    Products:
         
    OriGene clones in human, mouse for CTSW (see all 8)
    OriGene ORF clones in mouse, rat for CTSW
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTSW (NM_001335)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSW
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSW
    Sirion Biotech Customized lentivirus for stable overexpression of CTSW 
                         Customized lentivirus expression plasmids for stable overexpression of CTSW 
    Primer
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    OriGene qPCR primer pairs and template standards for CTSW
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSW
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSW

    Additional mRNA sequence: 

    AF013611.1 BC035637.1 BC048255.1 

    6 DOTS entries:

    DT.412309  DT.120708704  DT.120708723  DT.91659837  DT.120708722  DT.75101574 

    24/87 AceView cDNA sequences (see all 87):

    AA588693 BQ185511 AA311607 CD370188 AA523291 CR621885 AA235600 BU741330 
    CA308689 AL540662 AW135224 BM917105 AW137036 BI908056 BC048255 BQ051661 
    BI833187 AF013611 BP339319 NM_001335 BM724658 BG745157 CD611320 BP431062 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTSW expression in normal human tissues (normalized intensities)      CTSW embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCCCTTC
    CTSW Expression
    About this image


    CTSW expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T-Cytotoxic Cells Thymus
             Thymus
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Thyroid (Endocrine System)    fully expand to see all 2 entries
             thyroid gland ; glandular cells   
     
     Spleen (Hematopoietic System)
             spleen ; cells in red pulp   

    See CTSW Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTSW

    SOURCE GeneReport for Unigene cluster: Hs.416848

    UniProtKB/Swiss-Prot: CATW_HUMAN, P56202
    Tissue specificity: Expressed in natural killer and cytotoxic T cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSW

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CTSW gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctsw1 , 5 cathepsin W1, 5 76.64(n)1
    69(a)1
      19 (4.33 cM)5
    130411  NM_009985.41  NP_034115.21 
     54652405 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG121636
    --
    19(a)
    1 → many
    3R(1063373-1077468)
    worm
    (Caenorhabditis elegans)
    Secernentea R09F10.13 peptidase 33(a)
    (best of 2)
      X(8358887-8360238)   --


    ENSEMBL Gene Tree for CTSW (if available)
    TreeFam Gene Tree for CTSW (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTSW gene
    TINAG2  CTSF2  CTSO2  CTSV2  CTSK2  CTSB2  CTSS2  CTSH2  
    CTSC2  TINAGL12  CTSZ2  CTSL2  
    8 SIMAP similar genes for CTSW using alignment to 3 protein entries:     CATW_HUMAN (see all proteins):
    CTSF    CTSS    CTSL    CTSO    DKFZp686B24257    CTSL2
    CTSH    CTSL1

    CTSW for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/248 SNPs in CTSW are shown (see all 248)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0588474
    ----see VAR_0588472 S G mis40--------
    rs5960021,2
    C,A,H--61971871(+) GGTCAG/AGAGAT 1 -- us2k19Minor allele frequency- A:0.00NS EA NA 598
    rs1417881751,2
    --61972036(+) GAGATC/TGCACC 1 -- us2k10--------
    rs1893360461,2
    --61972076(+) GACTCC/TGTCTC 1 -- us2k10--------
    rs12046501,2
    C,A--61972097(+) ACAAAC/AAAAAG 1 -- us2k1 tfbs3 trp38Minor allele frequency- A:0.39NA WA EA 368
    rs1815032581,2
    --61972125(+) TGTAAA/GTGAAT 1 -- us2k10--------
    rs11515191,2
    C,F,A,H--61972348(+) CCTCCC/GTCTGT 1 -- us2k116Minor allele frequency- G:0.34MN NA EA CSA WA 921
    rs1854600061,2
    --61972393(+) CCCCTC/TATCCT 1 -- us2k10--------
    rs1505084531,2
    --61972449(+) CAGTTA/GCTGCT 1 -- us2k10--------
    rs1895713761,2
    --61972535(+) GAGTGC/TAATGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CTSW (65647280 - 65651212 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CTSW:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897764CNV Loss21882294
    nsv832191CNV Loss17160897
    dgv1185n71CNV Loss21882294
    nsv897736CNV Loss21882294
    dgv393e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CTSW
    DNA2.0 Custom Variant and Variant Library Synthesis for CTSW

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602364    OMIM disorders: --

    5 diseases for CTSW:    About MalaCards
    autoimmune atrophic gastritis    atrophic gastritis    gastritis    tuberculosis
    leukemia


    CTSW for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CTSW gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 7.44 1 9823953 (1)


    Export disorders for CTSW gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTSW gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with CTSW)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. (PubMed id 9108299)1, 2, 3, 9 Linnevers C.... Broemme D. (1997)
    2. Genomic structure, chromosomal localization, and expression of human cathepsin W. (PubMed id 9675123)1, 2, 3, 9 Wex T.... Bromme D. (1998)
    3. Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase. (PubMed id 9823953)1, 2, 9 Brown J....Enver T. (1998)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    6. Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum. (PubMed id 11490002)1, 9 Wex T....Bromme D. (2001)
    7. Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes. (PubMed id 10716634)1, 9 Brinkworth R.I....Dalton J.P. (2000)
    8. Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal tract. (PubMed id 12437118)1, 9 Buhling F....Wex T. (2002)
    9. Cathepsin W expressed exclusively in CD8+ T cells and NK cells, is secreted during target cell killing but is not essential for cytotoxicity in human CTLs. (PubMed id 19100676)1, 9 Stoeckle C....Tolosa E. (2009)
    10. Identification of a novel isoform predominantly expressed in gastric tissue and a triple-base pair polymorphism of the cathepsin W gene. (PubMed id 15358123)1, 9 Meinhardt C....Wex T. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1521 HGNC: 2546 AceView: CTSW Ensembl:ENSG00000172543 euGenes: HUgn1521
    ECgene: CTSW Kegg: 1521 H-InvDB: CTSW

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTSW Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTSW gene:
    Search GeneIP for patents involving CTSW

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