CTSW Gene
protein-coding GIFtS: 57
GCID: GC11P065647
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cathepsin W(Previous name: cathepsin W (lymphopain) )
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Aliases
for CTSW gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cathepsin W1 2 | | Cathepsin W (Lymphopain)1 | | LYPN2 | | Lymphopain3 | | EC 3.4.22.-3 | | Lymphopain3 |
Export aliases for CTSW gene to outside databasesPrevious GC identifers: GC11P068181 GC11P067328 GC11P065897 GC11P065422 GC11P065405 GC11P061973 |
Summaries
for CTSW gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CTSW:
The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have aspecific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associatedwith the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene isup-regulated by interleukin-2. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CATW_HUMAN, P56202Function: May have a specific function in the mechanism or regulation of T-cell cytolytic activity
Gene Wiki entry for CTSW (Cathepsin W)
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Genomic Views
for CTSW gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CTSW gene promoter:
p53 ATF-2 Lmo2 IRF-1 Roaz PPAR-alpha FAC1 COMP1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for CTSW
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSW |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1CTSW Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P065647: view genomic region
(about GC identifiers)
Start:
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65,647,280 bp from pter |
End:
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65,651,212 bp from pter |
Size:
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3,933 bases |
Orientation:
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plus strand |
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Proteins
for CTSW gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CATW_HUMAN, P56202 (See
protein sequence)Recommended Name: Cathepsin W precursor Size: 376 amino acids; 42120 Da
Secondary accessions: Q86VT4Explore the universe of human proteins at neXtProt for CTSW: NX_P56202
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P56202
CTSW Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001326.2
ENSEMBL proteins: ENSP00000311300 ENSP00000436568 ENSP00000434267
Human Recombinant Protein Products:
CTSW Antibody Products:
Assay Products for CTSW: |
Protein
Domains /
Families
for CTSW gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CTSW for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P56202ProtoNet protein and cluster: P56202 2 Blocks protein families: IPB000668 Papain cysteine protease (C1) family signature IPB013201 Proteinase inhibitor I29
UniProtKB/Swiss-Prot: CATW_HUMAN, P56202Similarity: Belongs to the peptidase C1 family |
Function
for CTSW gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CATW_HUMAN, P56202Function: May have a specific function in the mechanism or regulation of T-cell cytolytic activity Genatlas biochemistry entry for CTSW:cathepsin W,cysteine protease,papain superfamily,expressed in endoplasmic reticulum in CD8+ T-lymphocytes,subgroupF-like protease
Enzyme Number (IUBMB): EC 3.4.22.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTSW (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTSW (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CTSW (NM_001335) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTSW | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSW |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSW |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008234 | cysteine-type peptidase activity |
IEA | -- |
CTSW for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CTSW:
Animal Models:
Mouse knock-out Ctswtm1Ctnp for CTSW
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ctsw):
CTSW for phenotypes About GeneDecksing
|
Pathways & Interactions
for CTSW gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Lysosome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for CTSW):
CTSW for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTSW
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for CTSW (P562023 ENSP000003113004) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
CTSW for ontologies About GeneDecksing
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Drugs & Compounds
for CTSW gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CTSW for compounds About GeneDecksing
 Browse Tocris compounds for CTSW
3 Novoseek chemical compound relationships for CTSW gene About this table
Search CenterWatch for drugs/clinical trials and news about CTSW / CATW
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Transcripts
for CTSW gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CTSW gene: NM_001335.3 Unigene Cluster for CTSW: Cathepsin W Hs.416848 [show with all ESTs]Unigene Representative Sequence: BC0482554 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000307886(uc001ogc.1) ENST00000524681 ENST00000528419 ENST00000526034
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTSW (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTSW (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CTSW (NM_001335) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTSW | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSW |
Additional cDNA sequence: AF013611.1 BC035637.1 BC048255.1 6 DOTS entries: DT.412309 DT.120708704 DT.120708723 DT.91659837 DT.120708722 DT.75101574 24/87 AceView cDNA sequences (see all 87): AA523291 AA235600 AA311607 BQ185511 CR621885 BU741330 CD370188 AA588693 BQ052762 BV195164 AA410838 BC048255 BX283355 BM724658 BM916973 BM564355 AW958483 BM917206 BU151606 AA309618 AF013611 AL540662 BU624108 BX356621
GeneLoc Exon Structure
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Expression
for CTSW gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CTSW expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCCCCTTC
About this image
See CTSW Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTSW
SOURCE GeneReport for Unigene cluster: Hs.416848
UniProtKB/Swiss-Prot: CATW_HUMAN, P56202Tissue specificity: Expressed in natural killer and cytotoxic T cells
SABiosciences Custom PCR Arrays for CTSW
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTSW
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTSW | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSW | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSW | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSW |
Orthologs
for CTSW gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CTSW gene from 5/19 species (see all 19) About this table
ENSEMBL Gene Tree for CTSW (if available)
TreeFam Gene Tree for CTSW (if available) |
Paralogs
for CTSW gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CTSW gene
- TINAG2 CTSL12 CTSF2 CTSO2 CTSK2 CTSB2 CTSL22 CTSS2
- CTSH2 CTSC2 TINAGL12 CTSZ2
8 SIMAP similar genes for CTSW using alignment to 3 protein entries: CATW_HUMAN (see all proteins):CTSF CTSS CTSL CTSO DKFZp686B24257 CTSL2
CTSH CTSL1
CTSW for paralogs About GeneDecksing
|
Genomic Variants
for CTSW gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CTSW (65647280 - 65651212 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CTSW
1 CNV: 3855 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTSW |
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Disorders
/ Diseases
for CTSW gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CTSW for disorders About GeneDecksing
OMIM gene information: 602364
OMIM disorders: --
4  diseases for CTSW: About MalaCardsatrophic gastritis gastritis leukemia tuberculosis
1 Novoseek disease relationship for CTSW gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia |
7.44 |
1 |
9823953 (1) |
Export disorders for CTSW gene to outside databases
|
Publications
for CTSW gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CTSW gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with CTSW) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. (PubMed id 9108299)1, 2, 3, 9 Linnevers C.... Broemme D. (1997)
- Genomic structure, chromosomal localization, and expression of human cathepsin W. (PubMed id 9675123)1, 2, 3, 9 Wex T.... Bromme D. (1998)
- Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase. (PubMed id 9823953)1, 2, 9 Brown J....Enver T. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum. (PubMed id 11490002)1, 9 Wex T....Bromme D. (2001)
- Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes. (PubMed id 10716634)1, 9 Brinkworth R.I....Dalton J.P. (2000)
- Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal tract. (PubMed id 12437118)1, 9 Buhling F....Wex T. (2002)
- Cathepsin W expressed exclusively in CD8+ T cells and NK cells, is secreted during target cell killing but is not essential for cytotoxicity in human CTLs. (PubMed id 19100676)1, 9 Stoeckle C....Tolosa E. (2009)
- Identification of a novel isoform predominantly expressed in gastric tissue and a triple-base pair polymorphism of the cathepsin W gene. (PubMed id 15358123)1, 9 Meinhardt C....Wex T. (2004)
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External Searches for CTSW gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CTSW gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CTSW gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CTSW gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CTSW | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CTSW gene:
Search GeneIP for patents involving CTSW
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CTSW gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CTSW | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTSW | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTSW | | | OriGene Protein Over-expression Lysate for CTSW | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CTSW | | OriGene 3'-UTR Clone for CTSW | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTSW | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTSW | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CTSW | | OriGene Custom Protein Services for CTSW | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTSW | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTSW | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSW | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSW | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSW | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSW |
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 |  |  |  | |
| | | | Search Tocris compounds for CTSW |
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 | | | CTSW Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSW |
|  |  |  | | | | ThermoFisher Antibodies for CTSW |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSW |
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