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Aliases for CTSW Gene

Aliases for CTSW Gene

  • Cathepsin W 2 3
  • Lymphopain 3 4
  • Cathepsin W (Lymphopain) 2
  • EC 3.4.22.- 4
  • LYPN 3

External Ids for CTSW Gene

Summaries for CTSW Gene

Entrez Gene Summary for CTSW Gene

  • The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTSW Gene

CTSW (Cathepsin W) is a Protein Coding gene. Diseases associated with CTSW include autoimmune atrophic gastritis. Among its related pathways are Lysosome. GO annotations related to this gene include cysteine-type peptidase activity. An important paralog of this gene is CTSV.

UniProtKB/Swiss-Prot for CTSW Gene

  • May have a specific function in the mechanism or regulation of T-cell cytolytic activity

Gene Wiki entry for CTSW Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSW Gene

Genomics for CTSW Gene

Genomic Location for CTSW Gene

Start:
65,879,809 bp from pter
End:
65,883,741 bp from pter
Size:
3,933 bases
Orientation:
Plus strand

Genomic View for CTSW Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTSW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSW Gene

Regulatory Elements for CTSW Gene

Proteins for CTSW Gene

  • Protein details for CTSW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56202-CATW_HUMAN
    Recommended name:
    Cathepsin W
    Protein Accession:
    P56202
    Secondary Accessions:
    • Q86VT4

    Protein attributes for CTSW Gene

    Size:
    376 amino acids
    Molecular mass:
    42120 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTSW Gene

Proteomics data for CTSW Gene at MOPED

Post-translational modifications for CTSW Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn50 and Asn205

Other Protein References for CTSW Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTSW Gene

Domains for CTSW Gene

Gene Families for CTSW Gene

HGNC:
  • CTS :Cathepsins

UniProtKB/Swiss-Prot:

CATW_HUMAN
Family:
  • Belongs to the peptidase C1 family.:
    • P56202
genes like me logo Genes that share domains with CTSW: view

Function for CTSW Gene

Molecular function for CTSW Gene

GENATLAS Biochemistry: cathepsin W,cysteine protease,papain superfamily,expressed in endoplasmic reticulum in CD8+ T-lymphocytes,subgroup F-like protease
UniProtKB/Swiss-Prot Function: May have a specific function in the mechanism or regulation of T-cell cytolytic activity

Enzyme Numbers (IUBMB) for CTSW Gene

Gene Ontology (GO) - Molecular Function for CTSW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008234 cysteine-type peptidase activity IEA --
genes like me logo Genes that share ontologies with CTSW: view

Phenotypes for CTSW Gene

MGI mutant phenotypes for CTSW:
inferred from 1 alleles
GenomeRNAi human phenotypes for CTSW:
genes like me logo Genes that share phenotypes with CTSW: view

Animal Models for CTSW Gene

MGI Knock Outs for CTSW:

miRNA for CTSW Gene

miRTarBase miRNAs that target CTSW

No data available for Transcription Factor Targeting and HOMER Transcription for CTSW Gene

Localization for CTSW Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTSW Gene COMPARTMENTS Subcellular localization image for CTSW gene
Compartment Confidence
extracellular 3
lysosome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CTSW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CTSW: view

Pathways for CTSW Gene

SuperPathways for CTSW Gene

Superpath Contained pathways
1 Lysosome
genes like me logo Genes that share pathways with CTSW: view

Pathways by source for CTSW Gene

1 KEGG pathway for CTSW Gene

Interacting Proteins for CTSW Gene

Gene Ontology (GO) - Biological Process for CTSW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006955 immune response TAS 9823953
genes like me logo Genes that share ontologies with CTSW: view

Compounds for CTSW Gene

(3) Novoseek inferred chemical compound relationships for CTSW Gene

Compound -log(P) Hits PubMed IDs
cysteine 64.9 12
asparagine 43.1 1
histidine 27.6 1
genes like me logo Genes that share compounds with CTSW: view

Transcripts for CTSW Gene

mRNA/cDNA for CTSW Gene

Unigene Clusters for CTSW Gene

Cathepsin W:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTSW Gene

No ASD Table

Relevant External Links for CTSW Gene

GeneLoc Exon Structure for
CTSW
ECgene alternative splicing isoforms for
CTSW

Expression for CTSW Gene

mRNA expression in normal human tissues for CTSW Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSW Gene

This gene is overexpressed in Whole Blood (39.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CTSW Gene

SOURCE GeneReport for Unigene cluster for CTSW Gene Hs.416848

mRNA Expression by UniProt/SwissProt for CTSW Gene

P56202-CATW_HUMAN
Tissue specificity: Expressed in natural killer and cytotoxic T cells
genes like me logo Genes that share expressions with CTSW: view

Orthologs for CTSW Gene

This gene was present in the common ancestor of animals.

Orthologs for CTSW Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTSW 36
  • 99.47 (n)
  • 98.94 (a)
CTSW 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTSW 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTSW 36
  • 81.19 (n)
  • 73.8 (a)
CTSW 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctsw 36
  • 75.56 (n)
  • 67.92 (a)
Ctsw 16
Ctsw 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTSW 37
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 39 (a)
OneToMany
-- 37
  • 48 (a)
OneToMany
-- 37
  • 48 (a)
OneToMany
-- 37
  • 37 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ctsw 36
  • 75.56 (n)
  • 69 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 17 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ctsw 36
  • 54.4 (n)
  • 48.83 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:110239 37
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12163 37
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-196 37
  • 23 (a)
OneToMany
R07E3.1 38
  • 29 (a)
R09F10.1 38
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2594 37
  • 39 (a)
OneToMany
Species with no ortholog for CTSW:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSW Gene

ENSEMBL:
Gene Tree for CTSW (if available)
TreeFam:
Gene Tree for CTSW (if available)

Paralogs for CTSW Gene

Paralogs for CTSW Gene

Selected SIMAP similar genes for CTSW Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTSW: view

Variants for CTSW Gene

Sequence variations from dbSNP and Humsavar for CTSW Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs514506 -- 65,880,517(+) ggttt(C/G)accat intron-variant
rs596002 -- 65,877,883(+) GGTCA(A/G)GAGAT upstream-variant-2KB
rs601863 -- 65,879,086(+) ccggc(A/C)TGCTT upstream-variant-2KB
rs606830 - 65,882,812(+) GTTCC(A/G)GGGCA reference, missense
rs613457 -- 65,879,396(+) cctgt(A/T)atccc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CTSW Gene

Variant ID Type Subtype PubMed ID
nsv897736 CNV Loss 21882294
dgv393e1 CNV Complex 17122850
dgv1185n71 CNV Loss 21882294
nsv897764 CNV Loss 21882294
nsv832191 CNV Loss 17160897

Relevant External Links for CTSW Gene

HapMap Linkage Disequilibrium report
CTSW

Disorders for CTSW Gene

(1) Novoseek inferred disease relationships for CTSW Gene

Disease -log(P) Hits PubMed IDs
leukemia 7.44 1
genes like me logo Genes that share disorders with CTSW: view

No data available for UniProtKB/Swiss-Prot for CTSW Gene

Publications for CTSW Gene

  1. Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes. (PMID: 9108299) Linnevers C. … Broemme D. (FEBS Lett. 1997) 2 3 4 23
  2. Genomic structure, chromosomal localization, and expression of human cathepsin W. (PMID: 9675123) Wex T. … Bromme D. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  3. Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase. (PMID: 9823953) Brown J. … Enver T. (Leukemia 1998) 3 4 23
  4. Human cathepsins F and W: a new subgroup of cathepsins. (PMID: 10362521) Wex T. … Bromme D. (Biochem. Biophys. Res. Commun. 1999) 3 23
  5. Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes. (PMID: 10716634) Brinkworth R.I. … Dalton J.P. (Int. J. Biochem. Cell Biol. 2000) 3 23

Products for CTSW Gene

Sources for CTSW Gene

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