Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CTSV Gene

Aliases for CTSV Gene

  • Cathepsin V 2 3 4
  • Cathepsin L2 2 3
  • Cathepsin U 3 4
  • CTSL2 3 4
  • CATL2 3 4
  • CTSU 3 4
  • Cathepsin L2, Preproprotein 3
  • EC 3.4.22.43 4
  • EC 3.4.22 63
  • CTSL2, 6

External Ids for CTSV Gene

Previous HGNC Symbols for CTSV Gene

  • CTSL2

Previous GeneCards Identifiers for CTSV Gene

  • GC09M099791

Summaries for CTSV Gene

Entrez Gene Summary for CTSV Gene

  • The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]

GeneCards Summary for CTSV Gene

CTSV (Cathepsin V) is a Protein Coding gene. Diseases associated with CTSV include osteoarthritis and atherosclerosis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Endochondral Ossification. GO annotations related to this gene include protein complex binding and cysteine-type endopeptidase activity. An important paralog of this gene is CTSW.

UniProtKB/Swiss-Prot for CTSV Gene

  • Cysteine protease. May have an important role in corneal physiology.

Gene Wiki entry for CTSV Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSV Gene

Genomics for CTSV Gene

Genomic Location for CTSV Gene

Start:
97,029,677 bp from pter
End:
97,039,643 bp from pter
Size:
9,967 bases
Orientation:
Minus strand

Genomic View for CTSV Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTSV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSV Gene

No data available for Regulatory Elements for CTSV Gene

Proteins for CTSV Gene

  • Protein details for CTSV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60911-CATL2_HUMAN
    Recommended name:
    Cathepsin L2
    Protein Accession:
    O60911
    Secondary Accessions:
    • O60233
    • Q2TB86
    • Q5T1U0

    Protein attributes for CTSV Gene

    Size:
    334 amino acids
    Molecular mass:
    37329 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTSV Gene

neXtProt entry for CTSV Gene

Proteomics data for CTSV Gene at MOPED

Post-translational modifications for CTSV Gene

  • Glycosylation at Asn221 and Asn292
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSV Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CTSV Gene

Gene Families for CTSV Gene

HGNC:
  • CTS :Cathepsins

Graphical View of Domain Structure for InterPro Entry

O60911

UniProtKB/Swiss-Prot:

CATL2_HUMAN :
  • O60911
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSV: view

No data available for Suggested Antigen Peptide Sequences for CTSV Gene

Function for CTSV Gene

Molecular function for CTSV Gene

GENATLAS Biochemistry: cathepsin V,thymus and testis specific cysteine protease
UniProtKB/Swiss-Prot CatalyticActivity: The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).
UniProtKB/Swiss-Prot Function: Cysteine protease. May have an important role in corneal physiology.

Enzyme Numbers (IUBMB) for CTSV Gene

Gene Ontology (GO) - Molecular Function for CTSV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IEA --
GO:0004197 cysteine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 12809493
GO:0008234 cysteine-type peptidase activity TAS 9563472
GO:0016807 cysteine-type carboxypeptidase activity IEA --
genes like me logo Genes that share ontologies with CTSV: view

Phenotypes for CTSV Gene

genes like me logo Genes that share phenotypes with CTSV: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CTSV Gene

Localization for CTSV Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSV Gene

Lysosome.

Gene Ontology (GO) - Cellular Components for CTSV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with CTSV: view

No data available for Subcellular locations from COMPARTMENTS for CTSV Gene

Pathways for CTSV Gene

genes like me logo Genes that share pathways with CTSV: view

Interacting Proteins for CTSV Gene

Gene Ontology (GO) - Biological Process for CTSV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0007154 cell communication --
GO:0007283 spermatogenesis IEA --
GO:0008584 male gonad development --
GO:0009267 cellular response to starvation IEA --
genes like me logo Genes that share ontologies with CTSV: view

Compounds for CTSV Gene

(1) Novoseek inferred chemical compound relationships for CTSV Gene

Compound -log(P) Hits PubMed IDs
cysteine 71.2 13
genes like me logo Genes that share compounds with CTSV: view

Transcripts for CTSV Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CTSV Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: -
SP7: - -
SP8:

Relevant External Links for CTSV Gene

GeneLoc Exon Structure for
CTSV
ECgene alternative splicing isoforms for
CTSV

Expression for CTSV Gene

mRNA expression in normal human tissues for CTSV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSV Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (10.3), Testis (9.8), Skin - Sun Exposed (Lower leg) (8.6), Cervix - Ectocervix (6.3), and Esophagus - Mucosa (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CTSV Gene

mRNA Expression by UniProt/SwissProt for CTSV Gene

O60911-CATL2_HUMAN
Tissue specificity: Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
genes like me logo Genes that share expressions with CTSV: view

Orthologs for CTSV Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTSL2 35
  • 99.8 (n)
  • 99.4 (a)
CTSV 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTSL2 36
  • 80 (a)
OneToOne
CTSV 35
  • 83.68 (n)
  • 79.28 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
OneToMany
CTSL1 36
  • 82 (a)
OneToMany
CTSL1 36
  • 82 (a)
OneToMany
LOC102156614 35
  • 85.94 (n)
  • 83.13 (a)
mouse
(Mus musculus)
Mammalia Ctsl 35
  • 76.18 (n)
  • 75.38 (a)
Ctsl 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ctsl1 35
  • 77.38 (n)
  • 75.68 (a)
chicken
(Gallus gallus)
Aves CTSL2 35
  • 69.06 (n)
  • 67.37 (a)
CTSL2 36
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ctsv 35
  • 67.56 (n)
  • 65.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.166 35
zebrafish
(Danio rerio)
Actinopterygii ctsla 35
  • 68.17 (n)
  • 65.06 (a)
ctsla 36
  • 64 (a)
ManyToMany
ctslb 36
  • 57 (a)
ManyToMany
ctslb 36
  • 60 (a)
ManyToMany
ctslb 36
  • 60 (a)
ManyToMany
ctsll 36
  • 63 (a)
ManyToMany
si:dkey-239j18.2 36
  • 60 (a)
ManyToMany
si:dkey-239j18.3 36
  • 60 (a)
ManyToMany
si:dkey-269i1.3 36
  • 60 (a)
ManyToMany
si:dkey-269i1.4 36
  • 60 (a)
ManyToMany
si:dkey-269i1.4 36
  • 60 (a)
ManyToMany
si:dkey-26g8.4 36
  • 60 (a)
ManyToMany
si:dkey-26g8.5 36
  • 60 (a)
ManyToMany
zgc:174153 36
  • 60 (a)
ManyToMany
zgc:174855 36
  • 60 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011828 35
  • 55.93 (n)
  • 53.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cp1 35
  • 54.68 (n)
  • 51.36 (a)
Cp1 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpl-1 35
  • 53.07 (n)
  • 48.04 (a)
cpl-1 36
  • 48 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G19390 35
  • 49.17 (n)
  • 43.75 (a)
rice
(Oryza sativa)
Liliopsida Os04g0670200 35
  • 51.3 (n)
  • 48.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
Species with no ortholog for CTSV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSV Gene

ENSEMBL:
Gene Tree for CTSV (if available)
TreeFam:
Gene Tree for CTSV (if available)

Paralogs for CTSV Gene

Paralogs for CTSV Gene

Selected SIMAP similar genes for CTSV Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTSV: view

Variants for CTSV Gene

Sequence variations from dbSNP and Humsavar for CTSV Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs15394 -- 97,032,843(-) ATCAT(G/T)GAGGA utr-variant-3-prime
rs1131737 -- 97,037,501(-) CTTTT(C/G)GTGAC missense, reference
rs1131739 -- 97,037,500(-) TTTTG(C/G)TGACA missense, reference
rs2809782 -- 97,034,439(+) AAAAA(A/C)GCAAT intron-variant
rs2809783 -- 97,038,198(+) GGAGG(G/T)ATTTG intron-variant

Relevant External Links for CTSV Gene

HapMap Linkage Disequilibrium report
CTSV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CTSV Gene

Disorders for CTSV Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for CTSV Gene including...

Search for CTSV Gene in MalaCards »

(2) Novoseek inferred disease relationships for CTSV Gene

Disease -log(P) Hits PubMed IDs
breast cancer 0 2
tumors 0 3
genes like me logo Genes that share disorders with CTSV: view

No data available for UniProtKB/Swiss-Prot for CTSV Gene

Publications for CTSV Gene

  1. Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. (PMID: 9563472) Santamaria I. … Lopez-Otin C. (Cancer Res. 1998) 2 3 4 23
  2. Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. (PMID: 10029531) Broemme D. … Mehler E. (Biochemistry 1999) 2 3 4 23
  3. Genomic organization and chromosomal localization of the human cathepsin L2 gene. (PMID: 10382972) Itoh R. … Okubo K. (DNA Res. 1999) 3 4 23
  4. Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium. (PMID: 9727401) Adachi W. … Okubo K. (Invest. Ophthalmol. Vis. Sci. 1998) 3 4 23
  5. Crystal structure of human cathepsin V. (PMID: 11027133) Somoza J.R. … McGrath M.E. (Biochemistry 2000) 3 4 23

Products for CTSV Gene

Sources for CTSV Gene

Back to Top

Content