Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CTSV Gene

protein-coding   GIFtS: 49
GCID: GC09M099791

Cathepsin V

(Previous name: cathepsin L2)
(Previous symbol: CTSL2)
  See CTSV-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cathepsin V1 2 3     CTSU2 3
CTSL21 2 3 5     Cathepsin L2, Preproprotein2
Cathepsin L21 2     EC 3.4.22.433
Cathepsin U2 3     EC 3.4.228
CATL22 3     

External Ids:    HGNC: 25381   Entrez Gene: 15152   Ensembl: ENSG000001369437   OMIM: 6033085   UniProtKB: O609113   

Export aliases for CTSV gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CTSV Gene:
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may
play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not
in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor
processes. Alternatively spliced variants, encoding the same protein, have been identified. (provided by RefSeq,
Jan 2011)

GeneCards Summary for CTSV Gene:
CTSV (cathepsin V) is a protein-coding gene. Diseases associated with CTSV include osteoarthritis, and rheumatoid arthritis. GO annotations related to this gene include cysteine-type endopeptidase activity and protein complex binding. An important paralog of this gene is CTSF.

UniProtKB/Swiss-Prot: CATL2_HUMAN, O60911
Function: Cysteine protease. May have an important role in corneal physiology

summary for CTSV Gene:
Cathepsins are a group of lysosomal proteases that have a key role in cellular protein turnover. The term
cathepsin includes serine proteases (cathepsins A and G), aspartic proteases (cathepsin D and E) as well as
the cysteine proteases (cathepsins B, C, F, H, K, L, O, S, W and Z). Most cathepsins are endopeptidases,
with the exception of cathepsin C and Z. Cathepsins are synthesized as inactive proenzymes, glycosylated
post-translationally, and directed towards the lysosomal compartment by cellular mannose-6-phosphate
receptors. Their activity is regulated by several mechanisms including regulation of synthesis, zymogen
processing, inhibition by endogenous inhibitors (e.g. stefins and cystatins for cysteine cathepsins) and pH.
The main function of cathepsins is protein recycling within the lysosome but they are also known to be
involved in a range of other physiological, as well as pathological processes, including maturation of the
MHC class II complex, bone remodeling, keratinocyte differentiation, tumor progression and metastasis,
rheumatoid arthritis, osteoarthritis and atherosclerosis.

Gene Wiki entry for CTSV (Cathepsin L2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Search for regulatory transcription factor binding sites for CTSV
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTSV promoter sequence
   Search Chromatin IP Primers for CTSV

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTSV


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.2   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22.33

CTSV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSV gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M099791:  view genomic region     (about GC identifiers)

Start:
99,791,959 bp from pter      End:
99,801,925 bp from pter
Size:
9,967 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CATL2_HUMAN, O60911 (See protein sequence)
Recommended Name: Cathepsin L2 precursor  
Size: 334 amino acids; 37329 Da
3 PDB 3D structures from and Proteopedia for CTSV:
1FH0 (3D)        3H6S (3D)        3KFQ (3D)    
Secondary accessions: O60233 Q2TB86 Q5T1U0

Explore the universe of human proteins at neXtProt for CTSV: NX_O60911

Explore proteomics data for CTSV at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn221, Asn292
  • Selected DME Specific Peptides for CTSV (O60911) (see all 18)
     QNLVDCS  LVSLSEQ  THRRLYG  ATAASYP 


    See CTSV Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001188504.1  NP_001324.2  

    ENSEMBL proteins: 
     ENSP00000259470   ENSP00000445052  
    Reactome Protein details: O60911

    CTSV Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CTSV (Cathepsin V)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CTSV
    OriGene Protein Over-expression Lysate for CTSV
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CTSV
    GenScript Custom Purified and Recombinant Proteins Services for CTSV
    Novus Biologicals CTSV Protein
    Novus Biologicals CTSV Lysates
    Sino Biological Recombinant Protein for CTSV
    Sino Biological Cell Lysate for CTSV
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTSV

     
    Search eBioscience for Proteins for CTSV 

    CTSV Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CTSV
    R&D Systems Antibodies for CTSV (Cathepsin V)
    OriGene Antibodies for CTSV
    OriGene Custom Antibody Services for CTSV
    Novus Biologicals CTSV Antibodies
    Search for Antibodies for CTSV at Abcam
    Cloud-Clone Corp. Antibodies for CTSV
    Search ThermoFisher Antibodies for CTSV
    LSBio Antibodies in human, mouse, rat for CTSV

    CTSV Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CTSV
    R&D Systems ELISAs for CTSV (Cathepsin V)         (see all)
    GenScript Custom Assay Services for CTSV
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CTSV
    Cloud-Clone Corp. CLIAs for CTSV
    Search eBioscience for ELISAs for CTSV 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CTS: Cathepsins

    Selected InterPro protein domains (see all 6):
     IPR013128 Peptidase_C1A
     IPR025661 Pept_asp_AS
     IPR000169 Pept_cys_AS
     IPR013201 Prot_inhib_I29
     IPR025660 Pept_his_AS

    Graphical View of Domain Structure for InterPro Entry O60911

    ProtoNet protein and cluster: O60911

    2 Blocks protein domains:
    IPB000668 Papain cysteine protease (C1) family signature
    IPB013201 Proteinase inhibitor I29


    UniProtKB/Swiss-Prot: CATL2_HUMAN, O60911
    Similarity: Belongs to the peptidase C1 family


    Find genes that share domains with CTSV           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATL2_HUMAN, O60911
    Function: Cysteine protease. May have an important role in corneal physiology
    Catalytic activity: The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates
    (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec)

         Genatlas biochemistry entry for CTSV:
    cathepsin V,thymus and testis specific cysteine protease

         Enzyme Numbers (IUBMB): EC 3.4.22.431 EC 3.4.222

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0004197cysteine-type endopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0008234cysteine-type peptidase activity TAS9563472
    GO:0030984kininogen binding IEA--
         
    Find genes that share ontologies with CTSV           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CTSV:
     Decreased focal adhesion (FA)   Increased viability after born 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTSV
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTSV

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTSV
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTSV

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CTSV using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CTSV
    SwitchGear 3'UTR luciferase reporter plasmidCTSV 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CTSV
    Predesigned siRNA for gene silencing in human, mouse, rat CTSV

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CTSV

    Clone
    Products:
         
    OriGene clones in human, mouse for CTSV (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CTSV
    Sino Biological Human cDNA Clone for CTSV
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSV

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CTSV
    Browse ESI BIO Cell Lines and PureStem Progenitors for CTSV 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSV


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CATL2_HUMAN, O60911: Lysosome (Potential)

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005737cytoplasm ----
    GO:0005764lysosome ----
    GO:0005773vacuole ----
    GO:0005902microvillus IEA--

    Find genes that share ontologies with CTSV           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CTSV About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    2CDK-mediated phosphorylation and removal of Cdc6
    Antigen processing-Cross presentation0.80
    Endosomal/Vacuolar pathway0.00
    3Collagen biosynthesis and modifying enzymes
    Collagen formation0.75
    Assembly of collagen fibrils and other multimeric structures0.62
    4Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    5Matrix Metalloproteinases
    Activation of Matrix Metalloproteinases0.37


    Find genes that share SuperPaths with CTSV           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CTSV
        Endochondral Ossification


    Selected Reactome Pathways for CTSV (see all 6)
        Endosomal/Vacuolar pathway
    Assembly of collagen fibrils and other multimeric structures
    Trafficking and processing of endosomal TLR
    Degradation of the extracellular matrix
    Activation of Matrix Metalloproteinases


    1 Kegg Pathway  (Kegg details for CTSV):
        Lysosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTSV
    Interactions:

        Search GeneGlobe Interaction Network for CTSV

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTSV (O609113 ENSP000002594704) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC2A4P146723I2D: score=1 
    CSTAENSP000002644744STRING: ENSP00000264474
    CTSSENSP000003579814STRING: ENSP00000357981
    IFI30ENSP000003848864STRING: ENSP00000384886
    CD74ENSP000000095304STRING: ENSP00000009530
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007154cell communication ----
    GO:0007283spermatogenesis IEA--
    GO:0008584male gonad development ----
    GO:0009267cellular response to starvation IEA--

    Find genes that share ontologies with CTSV           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CTSV available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CalpeptinCalpain and cathepsin L inhibitor[117591-20-5]
    N-Acetyl-L-leucyl-L-leucyl-L-methionalCathepsin inhibitor[136632-32-1]
    E 64dCathepsin inhibitor; interferes with autolysosomal digestion[88321-09-9]
    L 006235Potent cathepsin K inhibitor[294623-49-7]
    SID 26681509Cathepsin L inhibitor[958772-66-2]

    1 Novoseek inferred chemical compound relationship for CTSV gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 71.2 17 11027133 (2), 9563472 (2), 10382972 (1), 12648222 (1) (see all 11)



    Find genes that share compounds with CTSV           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CTSV gene (2 alternative transcripts): 
    NM_001201575.1  NM_001333.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259470(uc004awt.3 uc010msj.2 uc010msk.3 uc010msi.3 uc004awu.3)
    ENST00000479932 ENST00000538255
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CTSV using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CTSV
    SwitchGear 3'UTR luciferase reporter plasmidCTSV 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CTSV
    Predesigned siRNA for gene silencing in human, mouse, rat CTSV
    Clone
    Products:
         
    OriGene clones in human, mouse for CTSV (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CTSV
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSV
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSV
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CTSV
    OriGene qSTAR qPCR primer pairs in human, mouse for CTSV
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CTSV
      QuantiTect SYBR Green Assays in human, mouse, rat CTSV
      QuantiFast Probe-based Assays in human, mouse, rat CTSV

    Selected AceView cDNA sequences (see all 98):

    BG679304 BM781965 BP368026 BP367312 BM764331 BI087441 BU619955 NM_001333 
    BM764323 AY358641 AW450930 BM127507 BM850210 BM127639 BC067289 BM852345 
    CK906127 AB001928 AI803574 AI368960 AA307011 CB156052 CA417449 AI867566 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CTSV (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10
    SP1:                          -     -           -     -                                         -     -                           
    SP2:        -     -     -     -     -           -     -                                                                           
    SP3:                          -     -           -     -                                                                           
    SP4:                                -           -     -                                                                           
    SP5:                          -     -                 -                                                                           


    ECgene alternative splicing isoforms for CTSV

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CTSV expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CTSV Expression
    About this image


    CTSV expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
     
     Thymus (Hematopoietic System)
    CTSV Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTSV Protein Expression

    UniProtKB/Swiss-Prot: CATL2_HUMAN, O60911
    Tissue specificity: Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to
    a lesser extent in conjunctival epithelium and skin

        Custom PCR Arrays for CTSV
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CTSV
    OriGene qSTAR qPCR primer pairs in human, mouse for CTSV
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CTSV
    QuantiTect SYBR Green Assays in human, mouse, rat CTSV
    QuantiFast Probe-based Assays in human, mouse, rat CTSV
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSV

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CTSV gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctsl1 cathepsin L 76.18(n)
    75.38(a)
      13039  NM_009984.3  NP_034114.1 
    chicken
    (Gallus gallus)
    Aves CTSL21 cathepsin L2 69.06(n)
    67.37(a)
      427466  NM_001168009.1  NP_001161481.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    59(a)
    1 → many
    2(40926589-40945236)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ctsv1 cathepsin V 67.56(n)
    65.87(a)
      448179  NM_001004869.1  NP_001004869.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ctsla1 cathepsin La 68.17(n)
    65.06(a)
      321453  NM_212584.1  NP_997749.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cp11 Cysteine proteinase-1 54.68(n)
    51.36(a)
      36546  NM_079011.3  NP_523735.2 
    worm
    (Caenorhabditis elegans)
    Secernentea cpl-11 cpl-1 53.07(n)
    48.04(a)
      180111  NM_001269789.1  NP_001256718.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G193901 AT3G19390 49.17(n)
    43.75(a)
      821473  NM_112826.3  NP_566633.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g06702001 Os04g0670200 51.3(n)
    48.94(a)
      4337351  NM_001060746.1  NP_001054211.2 


    ENSEMBL Gene Tree for CTSV (if available)
    TreeFam Gene Tree for CTSV (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CTSV gene
    CTSF2  CTSO2  CTSW2  CTSK2  CTSS2  CTSH2  CTSC2  CTSZ2  
    CTSL2  
    8 SIMAP similar genes for CTSV using alignment to 1 protein entry:     CATL2_HUMAN:
    CTSL1    CTSL    CTSS    CTSK    CTSH    CTSF
    CTSO    CTSW

    Find genes that share paralogs with CTSV           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CTSV (see all 302)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895919031,2
    --99791494(+) TTCACG/TCCATT 2 -- int10--------
    rs1416518161,2
    C--99791572(+) TTTGTA/CTTTTT 2 -- int10--------
    rs1813841281,2
    --99791573(+) TTGTAC/TTTTTA 2 -- int10--------
    rs1461528431,2
    C--99791599(+) CACCAC/TGTTAG 2 -- int10--------
    rs1390320871,2
    --99791875(+) GCTGCA/TCAAGG 2 -- int10--------
    rs64778311,2
    C,F,A,H--99791912(+) tcaagG/Aatcaa 2 -- int125Minor allele frequency- A:0.12NS EA NA WA CSA 2353
    rs758648931,2
    F--99792056(+) CAAGTC/TATGTG 2 -- ut311Minor allele frequency- T:0.01NA 120
    rs1859212461,2
    --99792155(+) ATACAC/TGAATA 2 -- ut310--------
    rs101237541,2
    C,F,A,H--99792208(+) ATGTGT/CTGCAC 2 -- ut3121Minor allele frequency- C:0.35NS EA NA WA CSA 2322
    rs101237571,2
    C,F,A--99792249(+) CCATAT/CAGCCT 2 -- ut319Minor allele frequency- C:0.40NA WA CSA EA 369

    HapMap Linkage Disequilibrium report for CTSV (99791959 - 99801925 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CTSV: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTSV
    DNA2.0 Custom Variant and Variant Library Synthesis for CTSV

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603308    OMIM disorders: --

    3 diseases for CTSV:    
    About MalaCards
    osteoarthritis    rheumatoid arthritis    atherosclerosis


    Find genes that share disorders with CTSV           About GenesLikeMe

    2 Novoseek inferred disease relationships for CTSV gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 0 2 16322222 (1), 9563472 (1)
    tumors 0 4 9563472 (2), 12874860 (1)


    Export disorders for CTSV gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CTSV gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with CTSV)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. (PubMed id 10029531)1, 2, 3, 9 Broemme D.... Mehler E. (Biochemistry 1999)
    2. Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. (PubMed id 9563472)1, 2, 3, 9 Santamaria I....Lopez-Otin C. (Cancer Res. 1998)
    3. Crystal structure of human cathepsin V. (PubMed id 11027133)1, 2, 9 Somoza J.R.... McGrath M.E. (Biochemistry 2000)
    4. Genomic organization and chromosomal localization of the human cathepsin L2 gene. (PubMed id 10382972)1, 2, 9 Itoh R.... Okubo K. (DNA Res. 1999)
    5. Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium. (PubMed id 9727401)1, 2, 9 Adachi W.... Okubo K. (Invest. Ophthalmol. Vis. Sci. 1998)
    6. Determination of cathepsin V activity and intracellular trafficking by N-glycosylation. (PubMed id 22967898)1, 2 Niwa Y.... Simizu S. (FEBS Lett. 2012)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain- binding site. A novel clue for the role of cystatin M/E in epidermal cornification. (PubMed id 16565075)1, 9 Cheng T....Zeeuwen P.L. (J. Biol. Chem. 2006)
    10. Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. (PubMed id 15192101)1, 9 Yasuda Y....BrAPmme D. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1515 HGNC: 2538 AceView: CTSL2 Ensembl:ENSG00000136943 euGenes: HUgn1515
    ECgene: CTSV Kegg: 1515 H-InvDB: CTSV

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CTSV Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CTSV gene:
    Search GeneIP for patents involving CTSV

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CTSV
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for CTSV (Cathepsin V)   Browse Cell Culture Products  
     ELISAs for CTSV (Cathepsin V)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for CTSV (Cathepsin V)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for CTSV (Cathepsin V)  
     OriGene Antibodies for CTSV   OriGene RNAi products in human, mouse, rat for CTSV  
     OriGene qPCR primer pairs and template standards for CTSV   OriGene Protein Over-expression Lysate for CTSV  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CTSV  
     OriGene qSTAR qPCR primer pairs in human, mouse for CTSV   OriGene Purified Protein for CTSV  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CTSV   OriGene Custom Protein Services for CTSV  

     
     
     Block miRNA regulation of human, mouse, rat CTSV using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CTSV
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTSV Predesigned siRNA for gene silencing in human, mouse, rat CTSV
     QuantiFast Probe-based Assays in human, mouse, rat CTSV QuantiTect SYBR Green Assays in human, mouse, rat CTSV
     Custom PCR Arrays for CTSV Search Chromatin IP Primers for CTSV
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CTSV Search GeneGlobe Interaction Network for CTSV
     Search Regulatory tfbs for CTSV
     GenScript Custom Purified and Recombinant Proteins Services for CTSV GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CTSV
     GenScript Custom Assay Services for CTSV GenScript Custom overexpressing Cell Line Services for CTSV
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for CTSV
     Proteins for CTSV
     Cell Lysates for CTSV
     cDNA Clones for CTSV
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CTSV antibodies
     CTSV proteins
     CTSV lysates
     Search for Antibodies for CTSV at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CTSV
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CTSV
     Antibodies for CTSV
     ELISAs for CTSV
     CLIAs for CTSV



     Browse ESI BIO Cell Lines and PureStem Progenitors for CTSV
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSV
     SwitchGear 3'UTR luciferase reporter plasmids for CTSV
     SwitchGear Promoter luciferase reporter plasmids for CTSV
     Search ThermoFisher Antibodies for CTSV
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSV
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTSV
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTSV
     LSBio Antibodies in human, mouse, rat for CTSV
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CTSV
      Search eBioscience for proteins for CTSV
      Search eBioscience for elisas for CTSV
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CTSV gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4