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Aliases for CTSV Gene

Aliases for CTSV Gene

  • Cathepsin V 2 3 4 5
  • Cathepsin U 3 4
  • CTSL2 3 4
  • CATL2 3 4
  • CTSU 3 4
  • Cathepsin L2, Preproprotein 3
  • Cathepsin L2 2
  • EC 3.4.22.43 4
  • EC 3.4.22 63

External Ids for CTSV Gene

Previous HGNC Symbols for CTSV Gene

  • CTSL2

Previous GeneCards Identifiers for CTSV Gene

  • GC09M099791

Summaries for CTSV Gene

Entrez Gene Summary for CTSV Gene

  • The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]

GeneCards Summary for CTSV Gene

CTSV (Cathepsin V) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Immune System. GO annotations related to this gene include protein complex binding and cysteine-type endopeptidase activity. An important paralog of this gene is CTSW.

UniProtKB/Swiss-Prot for CTSV Gene

  • Cysteine protease. May have an important role in corneal physiology.

Gene Wiki entry for CTSV Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSV Gene

Genomics for CTSV Gene

Regulatory Elements for CTSV Gene

Promoters for CTSV Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CTSV on UCSC Golden Path with GeneCards custom track

Genomic Location for CTSV Gene

Chromosome:
9
Start:
97,029,677 bp from pter
End:
97,039,643 bp from pter
Size:
9,967 bases
Orientation:
Minus strand

Genomic View for CTSV Gene

Genes around CTSV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSV Gene

Proteins for CTSV Gene

  • Protein details for CTSV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60911-CATL2_HUMAN
    Recommended name:
    Cathepsin L2
    Protein Accession:
    O60911
    Secondary Accessions:
    • O60233
    • Q2TB86
    • Q5T1U0

    Protein attributes for CTSV Gene

    Size:
    334 amino acids
    Molecular mass:
    37329 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTSV Gene

neXtProt entry for CTSV Gene

Proteomics data for CTSV Gene at MOPED

Post-translational modifications for CTSV Gene

  • Glycosylation at Asn 221 and Asn 292
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSV Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for CTSV Gene

Gene Families for CTSV Gene

Suggested Antigen Peptide Sequences for CTSV Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60911

UniProtKB/Swiss-Prot:

CATL2_HUMAN :
  • Belongs to the peptidase C1 family.
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSV: view

Function for CTSV Gene

Molecular function for CTSV Gene

GENATLAS Biochemistry:
cathepsin V,thymus and testis specific cysteine protease
UniProtKB/Swiss-Prot CatalyticActivity:
The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).
UniProtKB/Swiss-Prot Function:
Cysteine protease. May have an important role in corneal physiology.

Enzyme Numbers (IUBMB) for CTSV Gene

genes like me logo Genes that share phenotypes with CTSV: view

Animal Models for CTSV Gene

MGI Knock Outs for CTSV:

Animal Model Products

miRNA for CTSV Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSV Gene

Localization for CTSV Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSV Gene

Lysosome.

Gene Ontology (GO) - Cellular Components for CTSV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0005773 vacuole IEA --
GO:0005902 microvillus IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with CTSV: view

No data available for Subcellular locations from COMPARTMENTS for CTSV Gene

Pathways & Interactions for CTSV Gene

genes like me logo Genes that share pathways with CTSV: view

Pathways by source for CTSV Gene

1 GeneTex pathway for CTSV Gene
1 BioSystems pathway for CTSV Gene

Interacting Proteins for CTSV Gene

Gene Ontology (GO) - Biological Process for CTSV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008584 male gonad development IEA --
GO:0010259 multicellular organism aging IEA --
GO:0014070 response to organic cyclic compound IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0021675 nerve development IEA --
genes like me logo Genes that share ontologies with CTSV: view

No data available for SIGNOR curated interactions for CTSV Gene

Drugs & Compounds for CTSV Gene

(6) Drugs for CTSV Gene - From: DrugBank, ApexBio, Novoseek, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
3-amino-5-phenylpentane Experimental Pharma Target 0
4-Methylpiperazin-1-Yl Carbonyl Group Experimental Pharma Target 0
E-64-c Pharma Inhibitor of cysteine proteinases 0
Odanacatib (MK-0822) Pharma Cathepsin K,potent and selective 0
MDL 28170 Pharma Calpain and cathepsin B inhibitor, selective, Potent, selective calpain and cathepsin B inhibitor 0

(4) Additional Compounds for CTSV Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Calpeptin
117591-20-5
L 006235
294623-49-7
N-Acetyl-L-leucyl-L-leucyl-L-methional
136632-32-1
SID 26681509
958772-66-2

(5) Tocris Compounds for CTSV Gene

Compound Action Cas Number
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
L 006235 Potent cathepsin K inhibitor 294623-49-7
MDL 28170 Potent, selective calpain and cathepsin B inhibitor 88191-84-8
N-Acetyl-L-leucyl-L-leucyl-L-methional Cathepsin inhibitor 136632-32-1
SID 26681509 Cathepsin L inhibitor 958772-66-2

(2) ApexBio Compounds for CTSV Gene

Compound Action Cas Number
E-64-c Inhibitor of cysteine proteinases 76684-89-4
Odanacatib (MK-0822) Cathepsin K,potent and selective 603139-19-1
genes like me logo Genes that share compounds with CTSV: view

Transcripts for CTSV Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CTSV Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: -
SP7: - -
SP8:

Relevant External Links for CTSV Gene

GeneLoc Exon Structure for
CTSV
ECgene alternative splicing isoforms for
CTSV

Expression for CTSV Gene

mRNA expression in normal human tissues for CTSV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSV Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x10.3), Testis (x9.8), Skin - Sun Exposed (Lower leg) (x8.6), Cervix - Ectocervix (x6.3), and Esophagus - Mucosa (x4.1).

Protein differential expression in normal tissues from HIPED for CTSV Gene

This gene is overexpressed in Hair follicle (47.6) and Cervix (21.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CTSV Gene



mRNA Expression by UniProt/SwissProt for CTSV Gene

O60911-CATL2_HUMAN
Tissue specificity: Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
genes like me logo Genes that share expression patterns with CTSV: view

Protein tissue co-expression partners for CTSV Gene

Primer Products

In Situ Assay Products

Orthologs for CTSV Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSV Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTSV 35
  • 83.68 (n)
  • 79.28 (a)
CTSL2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102156614 35
  • 85.94 (n)
  • 83.13 (a)
-- 36
  • 77 (a)
OneToMany
CTSL1 36
  • 82 (a)
OneToMany
CTSL1 36
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ctsl 35
  • 76.18 (n)
  • 75.38 (a)
Ctsl 16
Ctsl 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTSL2 35
  • 99.8 (n)
  • 99.4 (a)
CTSV 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctsl1 35
  • 77.38 (n)
  • 75.68 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves CTSL2 35
  • 69.06 (n)
  • 67.37 (a)
CTSL2 36
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ctsv 35
  • 67.56 (n)
  • 65.87 (a)
zebrafish
(Danio rerio)
Actinopterygii ctsla 35
  • 68.17 (n)
  • 65.06 (a)
ctsla 36
  • 64 (a)
ManyToMany
ctslb 36
  • 57 (a)
ManyToMany
ctslb 36
  • 60 (a)
ManyToMany
ctslb 36
  • 60 (a)
ManyToMany
ctsll 36
  • 63 (a)
ManyToMany
si:dkey-239j18.2 36
  • 60 (a)
ManyToMany
si:dkey-239j18.3 36
  • 60 (a)
ManyToMany
si:dkey-269i1.3 36
  • 60 (a)
ManyToMany
si:dkey-269i1.4 36
  • 60 (a)
ManyToMany
si:dkey-269i1.4 36
  • 60 (a)
ManyToMany
si:dkey-26g8.4 36
  • 60 (a)
ManyToMany
si:dkey-26g8.5 36
  • 60 (a)
ManyToMany
zgc:174153 36
  • 60 (a)
ManyToMany
zgc:174855 36
  • 60 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.166 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011828 35
  • 55.93 (n)
  • 53.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cp1 35
  • 54.68 (n)
  • 51.36 (a)
Cp1 36
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpl-1 35
  • 53.07 (n)
  • 48.04 (a)
cpl-1 36
  • 48 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G19390 35
  • 49.17 (n)
  • 43.75 (a)
rice
(Oryza sativa)
Liliopsida Os04g0670200 35
  • 51.3 (n)
  • 48.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
Species with no ortholog for CTSV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSV Gene

ENSEMBL:
Gene Tree for CTSV (if available)
TreeFam:
Gene Tree for CTSV (if available)

Paralogs for CTSV Gene

Paralogs for CTSV Gene

(8) SIMAP similar genes for CTSV Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTSV: view

Variants for CTSV Gene

Sequence variations from dbSNP and Humsavar for CTSV Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs15394 -- 97,032,843(-) ATCAT(G/T)GAGGA utr-variant-3-prime
rs1131737 -- 97,037,501(-) CTTTT(C/G)GTGAC reference, missense
rs1131739 -- 97,037,500(-) TTTTG(C/G)TGACA reference, missense
rs2809782 -- 97,034,439(+) AAAAA(A/C)GCAAT intron-variant
rs2809783 -- 97,038,198(+) GGAGG(G/T)ATTTG intron-variant

Variation tolerance for CTSV Gene

Residual Variation Intolerance Score: 57.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 35.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTSV Gene

HapMap Linkage Disequilibrium report
CTSV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CTSV Gene

Disorders for CTSV Gene

Relevant External Links for CTSV

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTSV

No disorders were found for CTSV Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTSV Gene

Publications for CTSV Gene

  1. Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. (PMID: 10029531) Broemme D. … Mehler E. (Biochemistry 1999) 2 3 4 23 67
  2. Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. (PMID: 9563472) Santamaria I. … Lopez-Otin C. (Cancer Res. 1998) 2 3 23
  3. Cathepsin V, but not cathepsins L, B and K, may release angiostatin-like fragments from plasminogen. (PMID: 18163891) Puzer L. … Carmona A.K. (Biol. Chem. 2008) 3 23
  4. Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis. (PMID: 17869649) Viken M.K. … Lie B.A. (Hum. Immunol. 2007) 3 23
  5. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain- binding site. A novel clue for the role of cystatin M/E in epidermal cornification. (PMID: 16565075) Cheng T. … Zeeuwen P.L. (J. Biol. Chem. 2006) 3 23

Products for CTSV Gene

Sources for CTSV Gene

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