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Aliases for CTSV Gene

Aliases for CTSV Gene

  • Cathepsin V 2 3 4
  • Cathepsin L2 2 3
  • Cathepsin U 3 4
  • CTSL2 3 4
  • CATL2 3 4
  • CTSU 3 4
  • Cathepsin L2, Preproprotein 3
  • EC 3.4.22.43 4
  • EC 3.4.22 64
  • CTSL2, 6

External Ids for CTSV Gene

Previous Symbols for CTSV Gene

  • CTSL2

Summaries for CTSV Gene

Entrez Gene Summary for CTSV Gene

  • The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]

GeneCards Summary for CTSV Gene

CTSV (Cathepsin V) is a Protein Coding gene. Diseases associated with CTSV include rheumatoid arthritis and osteoarthritis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Endochondral Ossification. GO annotations related to this gene include protein complex binding and cysteine-type endopeptidase activity. An important paralog of this gene is CTSW.

UniProtKB/Swiss-Prot for CTSV Gene

  • Cysteine protease. May have an important role in corneal physiology.

Tocris Summary for CTSV Gene

  • Cathepsins are a group of lysosomal proteases that have a key role in cellular protein turnover. The term cathepsin includes serine proteases (cathepsins A and G), aspartic proteases (cathepsin D and E) as well as the cysteine proteases (cathepsins B, C, F, H, K, L, O, S, W and Z). Most cathepsins are endopeptidases, with the exception of cathepsin C and Z. Cathepsins are synthesized as inactive proenzymes, glycosylated post-translationally, and directed towards the lysosomal compartment by cellular mannose-6-phosphate receptors. Their activity is regulated by several mechanisms including regulation of synthesis, zymogen processing, inhibition by endogenous inhibitors (e.g. stefins and cystatins for cysteine cathepsins) and pH. The main function of cathepsins is protein recycling within the lysosome but they are also known to be involved in a range of other physiological, as well as pathological processes, including maturation of the MHC class II complex, bone remodeling, keratinocyte differentiation, tumor progression and metastasis, rheumatoid arthritis, osteoarthritis and atherosclerosis.

Gene Wiki entry for CTSV Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSV Gene

Genomics for CTSV Gene

Genomic Location for CTSV Gene

Start:
97,029,677 bp from pter
End:
97,039,643 bp from pter
Size:
9,967 bases
Orientation:
Minus strand

Genomic View for CTSV Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTSV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSV Gene

No data available for Regulatory Elements for CTSV Gene

Proteins for CTSV Gene

  • Protein details for CTSV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60911-CATL2_HUMAN
    Recommended name:
    Cathepsin L2
    Protein Accession:
    O60911
    Secondary Accessions:
    • O60233
    • Q2TB86
    • Q5T1U0

    Protein attributes for CTSV Gene

    Size:
    334 amino acids
    Molecular mass:
    37329 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTSV Gene

neXtProt entry for CTSV Gene

Proteomics data for CTSV Gene at MOPED

Post-translational modifications for CTSV Gene

  • Glycosylation at Asn221 and Asn292

Other Protein References for CTSV Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CTSV Gene

Gene Families for CTSV Gene

HGNC:
  • CTS :Cathepsins

UniProtKB/Swiss-Prot:

CATL2_HUMAN
Family:
  • Belongs to the peptidase C1 family.:
    • O60911
genes like me logo Genes that share domains with CTSV: view

Function for CTSV Gene

Molecular function for CTSV Gene

GENATLAS Biochemistry: cathepsin V,thymus and testis specific cysteine protease
UniProtKB/Swiss-Prot CatalyticActivity: The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec).
UniProtKB/Swiss-Prot Function: Cysteine protease. May have an important role in corneal physiology.

Enzyme Numbers (IUBMB) for CTSV Gene

Gene Ontology (GO) - Molecular Function for CTSV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IEA --
GO:0004197 cysteine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 12809493
GO:0008234 cysteine-type peptidase activity TAS 9563472
GO:0016807 cysteine-type carboxypeptidase activity IEA --
genes like me logo Genes that share ontologies with CTSV: view

Phenotypes for CTSV Gene

genes like me logo Genes that share phenotypes with CTSV: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CTSV Gene

Localization for CTSV Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSV Gene

Lysosome.

Gene Ontology (GO) - Cellular Components for CTSV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with CTSV: view

Pathways for CTSV Gene

genes like me logo Genes that share pathways with CTSV: view

Interacting Proteins for CTSV Gene

Gene Ontology (GO) - Biological Process for CTSV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0007154 cell communication --
GO:0007283 spermatogenesis IEA --
GO:0008584 male gonad development --
GO:0009267 cellular response to starvation IEA --
genes like me logo Genes that share ontologies with CTSV: view

Compounds for CTSV Gene

(5) Tocris Compounds for CTSV Gene

Compound Action Cas Number
Calpeptin Calpain and cathepsin L inhibitor [117591-20-5]
E 64d Cathepsin inhibitor; interferes with autolysosomal digestion [88321-09-9]
L 006235 Potent cathepsin K inhibitor [294623-49-7]
N-Acetyl-L-leucyl-L-leucyl-L-methional Cathepsin inhibitor [136632-32-1]
SID 26681509 Cathepsin L inhibitor [958772-66-2]

(1) Novoseek inferred chemical compound relationships for CTSV Gene

Compound -log(P) Hits PubMed IDs
cysteine 71.2 13
genes like me logo Genes that share compounds with CTSV: view

Transcripts for CTSV Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CTSV Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: -
SP7: - -
SP8:

Relevant External Links for CTSV Gene

GeneLoc Exon Structure for
CTSV
ECgene alternative splicing isoforms for
CTSV

Expression for CTSV Gene

mRNA expression in normal human tissues for CTSV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSV Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (10.3), Testis (9.8), Skin - Sun Exposed (Lower leg) (8.6), Cervix - Ectocervix (6.3), and Esophagus - Mucosa (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CTSV Gene

mRNA Expression by UniProt/SwissProt for CTSV Gene

O60911-CATL2_HUMAN
Tissue specificity: Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.
genes like me logo Genes that share expressions with CTSV: view

Orthologs for CTSV Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTSL2 36
  • 99.8 (n)
  • 99.4 (a)
CTSV 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTSL2 37
  • 80 (a)
OneToOne
CTSV 36
  • 83.68 (n)
  • 79.28 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 77 (a)
OneToMany
CTSL1 37
  • 82 (a)
OneToMany
CTSL1 37
  • 82 (a)
OneToMany
LOC102156614 36
  • 85.94 (n)
  • 83.13 (a)
mouse
(Mus musculus)
Mammalia Ctsl 36
  • 76.18 (n)
  • 75.38 (a)
Ctsl 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ctsl1 36
  • 77.38 (n)
  • 75.68 (a)
chicken
(Gallus gallus)
Aves CTSL2 36
  • 69.06 (n)
  • 67.37 (a)
CTSL2 37
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ctsv 36
  • 67.56 (n)
  • 65.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.166 36
zebrafish
(Danio rerio)
Actinopterygii ctsla 36
  • 68.17 (n)
  • 65.06 (a)
ctsla 37
  • 64 (a)
ManyToMany
ctslb 37
  • 57 (a)
ManyToMany
ctslb 37
  • 60 (a)
ManyToMany
ctslb 37
  • 60 (a)
ManyToMany
ctsll 37
  • 63 (a)
ManyToMany
si:dkey-239j18.2 37
  • 60 (a)
ManyToMany
si:dkey-239j18.3 37
  • 60 (a)
ManyToMany
si:dkey-269i1.3 37
  • 60 (a)
ManyToMany
si:dkey-269i1.4 37
  • 60 (a)
ManyToMany
si:dkey-269i1.4 37
  • 60 (a)
ManyToMany
si:dkey-26g8.4 37
  • 60 (a)
ManyToMany
si:dkey-26g8.5 37
  • 60 (a)
ManyToMany
zgc:174153 37
  • 60 (a)
ManyToMany
zgc:174855 37
  • 60 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011828 36
  • 55.93 (n)
  • 53.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cp1 36
  • 54.68 (n)
  • 51.36 (a)
Cp1 37
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpl-1 36
  • 53.07 (n)
  • 48.04 (a)
cpl-1 37
  • 48 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G19390 36
  • 49.17 (n)
  • 43.75 (a)
rice
(Oryza sativa)
Liliopsida Os04g0670200 36
  • 51.3 (n)
  • 48.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
ManyToMany
-- 37
  • 47 (a)
ManyToMany
Species with no ortholog for CTSV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSV Gene

ENSEMBL:
Gene Tree for CTSV (if available)
TreeFam:
Gene Tree for CTSV (if available)

Paralogs for CTSV Gene

Paralogs for CTSV Gene

Selected SIMAP similar genes for CTSV Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTSV: view

Variants for CTSV Gene

Sequence variations from dbSNP and Humsavar for CTSV Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs15394 -- 97,032,843(-) ATCAT(G/T)GAGGA utr-variant-3-prime
rs1131737 -- 97,037,501(-) CTTTT(C/G)GTGAC missense, reference
rs1131739 -- 97,037,500(-) TTTTG(C/G)TGACA missense, reference
rs2809782 -- 97,034,439(+) AAAAA(A/C)GCAAT intron-variant
rs2809783 -- 97,038,198(+) GGAGG(G/T)ATTTG intron-variant

Relevant External Links for CTSV Gene

HapMap Linkage Disequilibrium report
CTSV

No data available for Structural Variations from Database of Genomic Variants (DGV) for CTSV Gene

Disorders for CTSV Gene

(2) Novoseek inferred disease relationships for CTSV Gene

Disease -log(P) Hits PubMed IDs
breast cancer 0 2
tumors 0 3
genes like me logo Genes that share disorders with CTSV: view

No data available for UniProtKB/Swiss-Prot for CTSV Gene

Publications for CTSV Gene

  1. Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. (PMID: 9563472) Santamaria I. … Lopez-Otin C. (Cancer Res. 1998) 2 3 4 23
  2. Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. (PMID: 10029531) Broemme D. … Mehler E. (Biochemistry 1999) 2 3 4 23
  3. Genomic organization and chromosomal localization of the human cathepsin L2 gene. (PMID: 10382972) Itoh R. … Okubo K. (DNA Res. 1999) 3 4 23
  4. Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium. (PMID: 9727401) Adachi W. … Okubo K. (Invest. Ophthalmol. Vis. Sci. 1998) 3 4 23
  5. Crystal structure of human cathepsin V. (PMID: 11027133) Somoza J.R. … McGrath M.E. (Biochemistry 2000) 3 4 23

Products for CTSV Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CTSV
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CTSV
    • Block miRNA regulation of CTSV using miScript Target Protectors

    Sources for CTSV Gene

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