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CTSS Gene

protein-coding   GIFtS: 71
GCID: GC01M150702

Cathepsin S

  See CTSS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cathepsin S1 2
EC 3.4.22.273 8
EC 3.4.228

External Ids:    HGNC: 25451   Entrez Gene: 15202   Ensembl: ENSG000001631317   OMIM: 1168455   UniProtKB: P257743   

Export aliases for CTSS gene to outside databases

Previous GC identifers: GC01M148546 GC01M146449 GC01M147477 GC01M147919 GC01M147515 GC01M148969 GC01M122080


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTSS Gene:
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may
participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The
encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced
transcript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for CTSS Gene:
CTSS (cathepsin S) is a protein-coding gene. Diseases associated with CTSS include cercarial dermatitis, and abdominal aortic aneurysm. GO annotations related to this gene include cysteine-type endopeptidase activity. An important paralog of this gene is CTSF.

UniProtKB/Swiss-Prot: CATS_HUMAN, P25774
Function: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II
molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and
cathepsin N

Gene Wiki entry for CTSS (Cathepsin S) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTSS gene promoter:
         STAT5B   TBP   STAT5A   IRF-1   Evi-1   AREB6   Ik-2   Ik-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTSS promoter sequence
   Search Chromatin IP Primers for CTSS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTSS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

CTSS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M150702:  view genomic region     (about GC identifiers)

Start:
150,702,672 bp from pter      End:
150,738,433 bp from pter
Size:
35,762 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CATS_HUMAN, P25774 (See protein sequence)
Recommended Name: Cathepsin S precursor  
Size: 331 amino acids; 37496 Da
Subunit: Monomer
Selected PDB 3D structures from and Proteopedia for CTSS (see all 30):
1BXF (3D)        1GLO (3D)        1MS6 (3D)        1NPZ (3D)        1NQC (3D)        2C0Y (3D)    
Secondary accessions: B4DWC9 D3DV05 Q5T5I0 Q6FHS5 Q9BUG3
Alternative splicing: 2 isoforms:  P25774-1   P25774-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CTSS: NX_P25774

Explore proteomics data for CTSS at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn104
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CTSS (P25774) (see all 14)
     GDMTSEE  PTLDHHW  VLVVGYG  QNLVDCS 


    See CTSS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186668.1  NP_004070.3  

    ENSEMBL proteins: 
     ENSP00000357981   ENSP00000475176   ENSP00000475557   ENSP00000408414   ENSP00000475812  
    Reactome Protein details: P25774

    CTSS Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for CTSS
    OriGene Purified Protein for CTSS
    OriGene Protein Over-expression Lysate for CTSS
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CTSS
    GenScript Custom Purified and Recombinant Proteins Services for CTSS
    Novus Biologicals CTSS Proteins
    Novus Biologicals CTSS Lysates
    Sino Biological Recombinant Protein for CTSS
    Sino Biological Cell Lysate for CTSS
    ProSpec Recombinant Protein for CTSS
    Cloud-Clone Corp. Proteins for CTSS

     
    Search eBioscience for Proteins for CTSS 

    CTSS Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CTSS
    R&D Systems Antibodies for CTSS (Cathepsin S)
    OriGene Antibodies for CTSS
    OriGene Custom Antibody Services for CTSS
    Novus Biologicals CTSS Antibodies
    Abcam antibodies for CTSS
    Cloud-Clone Corp. Antibodies for CTSS
    ThermoFisher Antibodies for CTSS
    LSBio Antibodies in human, mouse, rat for CTSS

    CTSS Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for CTSS (Cathepsin S)         (see all)
    GenScript CTSS-Activity-based Protease?src=genec Assay for Compound Screening
    Enzo Life Sciences assays for CTSS
    Cloud-Clone Corp. ELISAs for CTSS
    Cloud-Clone Corp. CLIAs for CTSS
    Search eBioscience for ELISAs for CTSS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CTS: Cathepsins

    Selected InterPro protein domains (see all 6):
     IPR013128 Peptidase_C1A
     IPR025661 Pept_asp_AS
     IPR000169 Pept_cys_AS
     IPR013201 Prot_inhib_I29
     IPR025660 Pept_his_AS

    Graphical View of Domain Structure for InterPro Entry P25774

    ProtoNet protein and cluster: P25774

    2 Blocks protein domains:
    IPB000668 Papain cysteine protease (C1) family signature
    IPB013201 Proteinase inhibitor I29


    UniProtKB/Swiss-Prot: CATS_HUMAN, P25774
    Similarity: Belongs to the peptidase C1 family


    Find genes that share domains with CTSS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATS_HUMAN, P25774
    Function: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II
    molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and
    cathepsin N
    Catalytic activity: Similar to cathepsin L, but with much less activity on Z-Phe-Arg- -NHMec, and more activity on
    the Z-Val-Val-Arg- -Xaa compound

         Genatlas biochemistry entry for CTSS:
    cathepsin S,lysosomal cysteine proteinase,expressed in spleen,heart and lung,papain superfamily,specifically
    involved in MHCII-associated chain processing and peptide loading

         Enzyme Numbers (IUBMB): EC 3.4.22.271 2 EC 3.4.222

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IPI--
    GO:0004197cysteine-type endopeptidase activity IDA--
    GO:0005518collagen binding IDA--
    GO:0008234cysteine-type peptidase activity ----
    GO:0043236laminin binding IDA--
         
    Find genes that share ontologies with CTSS           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CTSS:
     Cell cycle / mitosis defect  Decreased viability of wild-ty 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ctss):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  muscle  respiratory system  skeleton 

    Find genes that share phenotypes with CTSS           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CTSS: Ctsstm1Eae Ctsstm1Hap

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTSS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTSS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTSS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTSS

    miRNA
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    Block miRNA regulation of human, mouse, rat CTSS using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CTSS:
    hsa-miR-203 hsa-miR-370 hsa-miR-576-5p hsa-miR-520d-5p hsa-miR-561 hsa-miR-524-5p hsa-miR-32* hsa-miR-4282
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CTSS
    Predesigned siRNA for gene silencing in human, mouse, rat CTSS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CTSS

    Clone
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    OriGene clones in human, mouse for CTSS (see all 7)
    OriGene ORF clones in mouse, rat for CTSS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CTSS (NM_004079)
    Sino Biological Human cDNA Clone for CTSS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSS
    Addgene plasmids for CTSS 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CTSS 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSS

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13503) for CTSS 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CATS_HUMAN, P25774: Lysosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome5
    vacuole5
    endosome4
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    mitochondrion2
    nucleus2
    plasma membrane2
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005764lysosome IDA15196205
    GO:0016020membrane ----
    GO:0036021endolysosome lumen TAS--

    Find genes that share ontologies with CTSS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTSS About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    2CDK-mediated phosphorylation and removal of Cdc6
    Antigen processing-Cross presentation0.80
    Endosomal/Vacuolar pathway0.00
    3Collagen biosynthesis and modifying enzymes
    Collagen formation0.75
    Assembly of collagen fibrils and other multimeric structures0.62
    4Immune response Antigen presentation by MHC class II
    Immune response Antigen presentation by MHC class II0.46
    5Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34


    Find genes that share SuperPaths with CTSS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for CTSS
        Immune response Antigen presentation by MHC class II
    Bacterial infections in CF airways


    5 Reactome Pathways for CTSS
        Endosomal/Vacuolar pathway
    Assembly of collagen fibrils and other multimeric structures
    Trafficking and processing of endosomal TLR
    Degradation of the extracellular matrix
    MHC class II antigen presentation


    4 Kegg Pathways  (Kegg details for CTSS):
        Lysosome
    Phagosome
    Antigen processing and presentation
    Tuberculosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTSS: 
              Nephrotoxicity in human mouse rat
              Cancer Drug Targets in human mouse rat
              Antiviral Response in human mouse rat
              Autophagy in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CTSS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTSS (P257743 ENSP000003579814) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CST5P283253, ENSP000003071324I2D: score=2 STRING: ENSP00000307132
    PLCG1P191743, ENSP000002440074I2D: score=2 STRING: ENSP00000244007
    SERPINB3P295083, ENSP000002837524I2D: score=2 STRING: ENSP00000283752
    SERPINB4P485943, ENSP000003434454I2D: score=1 STRING: ENSP00000343445
    CST3P010343, ENSP000003661244I2D: score=2 STRING: ENSP00000366124
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002250adaptive immune response IEP15196205
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--
    GO:0006508proteolysis TAS1373132

    Find genes that share ontologies with CTSS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTSS (CATS)

    Selected DrugBank Compounds for CTSS (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide-- --target--17139284 17016423 10592235
    Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide-- --target--17139284 17016423 10592235
    Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide-- --target--17139284 17016423
    (1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE-- --target--10592235
    2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL-- --target--10592235
    N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE-- --target--10592235
    N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE-- --target--10592235
    N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide-- --target--10592235
    N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide-- --target--10592235
    N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTSS gene (2 alternative transcripts): 
    NM_001199739.1  NM_004079.4  

    Unigene Cluster for CTSS:

    Cathepsin S
    Hs.181301  [show with all ESTs]
    Unigene Representative Sequence: NM_004079
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368985(uc001evn.3 uc010pcj.2) ENST00000472977 ENST00000607427
    ENST00000448301 ENST00000483930 ENST00000480760
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate CTSS:
    hsa-miR-203 hsa-miR-370 hsa-miR-576-5p hsa-miR-520d-5p hsa-miR-561 hsa-miR-524-5p hsa-miR-32* hsa-miR-4282
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CTSS
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    GenScript: all cDNA clones in your preferred vector (see all 2): CTSS (NM_004079)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSS
    Addgene plasmids for CTSS 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CTSS
    OriGene qSTAR qPCR primer pairs in human, mouse for CTSS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTSS
      QuantiTect SYBR Green Assays in human, mouse, rat CTSS
      QuantiFast Probe-based Assays in human, mouse, rat CTSS
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13503) for CTSS 

    Additional mRNA sequence: 

    AK024855.1 AK226095.1 AK301472.1 AK314482.1 BC002642.2 CR541676.1 M86553.1 M90696.1 
    S93414.1 

    21 DOTS entries:

    DT.100881531  DT.100881528  DT.447092  DT.95327167  DT.121386657  DT.101976026  DT.100881533  DT.100696184 
    DT.121386672  DT.100036139  DT.100881522  DT.451535  DT.86859484  DT.92437887  DT.97847226  DT.100881525 
    DT.121386669  DT.121386670  DT.95327165  DT.95327185  DT.121386681 

    Selected AceView cDNA sequences (see all 328):

    AA411619 CR592748 BQ220905 AI471234 AI440119 CR626534 AJ706143 NM_004079 
    AI733867 BQ006623 AA367455 BQ053160 BU626629 CA308597 CR623699 AW515534 
    AI702418 AV716038 AI242415 CK429964 AA694163 AA814186 AA563663 BX116242 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CTSS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
    SP1:                                      -                 -                                 
    SP2:                                      -                                                   
    SP3:                                                                                          
    SP4:                          -     -     -                                                   
    SP5:                                                                                -         


    ECgene alternative splicing isoforms for CTSS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CTSS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTAAAAAA
    CTSS Expression
    About this image


    CTSS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    CTSS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTSS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.181301
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTSS: 
              Nephrotoxicity in human mouse rat
              Cancer Drug Targets in human mouse rat
              Antiviral Response in human mouse rat
              Autophagy in human mouse rat
              Cell Death PathwayFinder in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CTSS gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctss1 , 5 cathepsin S1, 5 80.97(n)1
    74.02(a)1
      3 (40.74 cM)5
    130401  NM_021281.31  NP_067256.41 
     955267865 
    chicken
    (Gallus gallus)
    Aves CTSS1 cathepsin S 66.67(n)
    67.99(a)
      425657  NM_001031345.1  NP_001026516.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTSS6
    cathepsin S
    64(a)
    1 ↔ 1
    GL343862.1(16639-38667)
    African clawed frog
    (Xenopus laevis)
    Amphibia ctss-prov2 cathepsin S 77.02(n)    BC056059.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054668.12   -- 72.5(n)   393398  BC054668.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G113201 AT4G11320 51.52(n)
    46.85(a)
      826734  NM_117203.3  NP_567377.1 


    ENSEMBL Gene Tree for CTSS (if available)
    TreeFam Gene Tree for CTSS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTSS gene
    CTSF2  CTSO2  CTSW2  CTSV2  CTSK2  CTSH2  CTSC2  CTSZ2  
    CTSL2  
    Selected SIMAP similar genes for CTSS using alignment to 3 protein entries:     CATS_HUMAN (see all proteins) (see all similar genes):
    COL24A1    MEFV    UBIAD1    ARMC4    FAM210A    TNFRSF17
    ZNF564    ZNF737    HKR1    ASB11    CHID1    LINC00596
    NF2    NPLOC4    RBMS2    TMEM44    TSEN2    ZNF738

    Find genes that share paralogs with CTSS           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTSS (see all 638)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1827305831,2
    C--150702217(+) CACCTC/TGGGAG 2 -- ds50010--------
    rs120953481,2
    C--150702264(+) agaccG/Cgcccg 2 -- ds50012Minor allele frequency- C:0.00NA 4
    rs1922670291,2
    --150702269(+) CGCCCC/GGCCAA 2 -- ds50010--------
    rs75408741,2
    C,F,H--150702663(+) agattA/Cgcaag 2 -- ds500119Minor allele frequency- C:0.39NS EA NA CSA WA 2338
    rs1852779731,2
    C--150702694(+) TTAATA/G/TTAAGT 4 -- ut310--------
    rs11368081,2
    C,F,H--150702717(-) tggagC/Gccctc 2 -- ut3112Minor allele frequency- G:0.34MN NS EA NA CSA WA 962
    rs1181048831,2
    C,F--150702736(+) TAAAGG/ACCCAA 2 -- ut311Minor allele frequency- A:0.03EA 120
    rs563883451,2
    C,F--150702769(+) TTTTTG/ATAGTA 2 -- ut311Minor allele frequency- A:0.50NA 2
    rs559609431,2
    C--150703035(+) CAGGC-/AGAAGGTC 2 -- cds10--------
    rs563635481,2
    C--150703037(+) GGCAG-/AAGGTCAG 2 -- cds10--------

    HapMap Linkage Disequilibrium report for CTSS (150702672 - 150738433 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CTSS:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1542672CNV Deletion17803354
    esv2717818CNV Deletion23290073
    esv1299298CNV Deletion17803354
    nsv437169CNV Loss16327808
    nsv872417CNV Loss21882294
    nsv872419CNV Loss21882294
    nsv872418CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTSS
    DNA2.0 Custom Variant and Variant Library Synthesis for CTSS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116845    OMIM disorders: --

    2 diseases for CTSS:    
    About MalaCards
    cercarial dermatitis    abdominal aortic aneurysm

    4 diseases from the University of Copenhagen DISEASES database for CTSS:
    Cancer     Arthritis     Cercarial dermatitis     Atherosclerosis

    Find genes that share disorders with CTSS           About GenesLikeMe

    Genetic Association Database (GAD): CTSS
    Human Genome Epidemiology (HuGE) Navigator: CTSS (14 documents)

    Export disorders for CTSS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTSS gene, integrated from 10 sources (see all 114):
    (articles sorted by number of sources associating them with CTSS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. (PubMed id 1373132)1, 2, 3 Shi G.-P.... Chapman H.A. (J. Biol. Chem. 1992)
    2. CTSS promoter -25G/A: not a risk factor for CHD in Chinese. (PubMed id 19593952)1, 4, 9 Sun A....Ge J. (Acta Cardiol 2009)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PubMed id 19336475)1, 4 Drenos F....Hingorani A.D. (Hum. Mol. Genet. 2009)
    5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    6. Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations. (PubMed id 18565099)1, 4 Spielmann N....ClAcment K. (Clin. Genet. 2008)
    7. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    8. Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers. (PubMed id 17622942)1, 4 Grossman I....Miller A. (Pharmacogenet. Genomics 2007)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Pharmacogenomics of responsiveness to interferon IFN-beta treatment in multiple sclerosis: a genetic screen of 100 type I interferon-inducible genes. (PubMed id 16338279)1, 4 Cunningham S....Vandenbroeck K. (Clin. Pharmacol. Ther. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1520 HGNC: 2545 AceView: CTSS Ensembl:ENSG00000163131 euGenes: HUgn1520
    ECgene: CTSS Kegg: 1520 H-InvDB: CTSS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTSS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTSS gene:
    Search GeneIP for patents involving CTSS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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