Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTSS Gene

protein-coding   GIFtS: 71
GCID: GC01M150702

Cathepsin S

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cathepsin S1 2
EC 3.4.22.273 8
EC 3.4.228

External Ids:    HGNC: 25451   Entrez Gene: 15202   Ensembl: ENSG000001631317   OMIM: 1168455   UniProtKB: P257743   

Export aliases for CTSS gene to outside databases

Previous GC identifers: GC01M148546 GC01M146449 GC01M147477 GC01M147919 GC01M147515 GC01M148969 GC01M122080


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTSS Gene:
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may
participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The
encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced
transcript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for CTSS Gene: 
CTSS (cathepsin S) is a protein-coding gene. Diseases associated with CTSS include cercarial dermatitis, and pycnodysostosis, and among its related super-pathways are Immune System and Collagen formation. GO annotations related to this gene include cysteine-type endopeptidase activity. An important paralog of this gene is TINAG.

UniProtKB/Swiss-Prot: CATS_HUMAN, P25774
Function: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II
molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and
cathepsin N

Gene Wiki entry for CTSS (Cathepsin S) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTSS gene promoter:
         STAT5B   TBP   STAT5A   IRF-1   Evi-1   AREB6   Ik-2   Ik-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTSS promoter sequence
   Search SABiosciences Chromatin IP Primers for CTSS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

CTSS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M150702:  view genomic region     (about GC identifiers)

Start:
150,702,672 bp from pter      End:
150,738,433 bp from pter
Size:
35,762 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CATS_HUMAN, P25774 (See protein sequence)
Recommended Name: Cathepsin S precursor  
Size: 331 amino acids; 37496 Da
Subunit: Monomer
Subcellular location: Lysosome
6/30 PDB 3D structures from and Proteopedia for CTSS (see all 30):
1BXF (3D)        1GLO (3D)        1MS6 (3D)        1NPZ (3D)        1NQC (3D)        2C0Y (3D)    
Secondary accessions: B4DWC9 D3DV05 Q5T5I0 Q6FHS5 Q9BUG3
Alternative splicing: 2 isoforms:  P25774-1   P25774-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CTSS: NX_P25774

Explore proteomics data for CTSS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P25774

  • 4/14 DME Specific Peptides for CTSS (P25774) (see all 14)
     GDMTSEE  PTLDHHW  VLVVGYG  QNLVDCS 

    CTSS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CTSS Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186668.1  NP_004070.3  

    ENSEMBL proteins: 
     ENSP00000357981   ENSP00000475176   ENSP00000475557   ENSP00000408414   ENSP00000475812  
    Reactome Protein details: P25774
    Human Recombinant Protein Products for CTSS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CTSS (Cathepsin S)
    Enzo Life Sciences proteins for CTSS
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CTSS
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CTSS
    GenScript Custom Purified and Recombinant Proteins Services for CTSS
    Novus Biologicals CTSS Proteins
    Novus Biologicals CTSS Lysates
    Sino Biological Recombinant Protein for CTSS
    Sino Biological Cell Lysate for CTSS 
    ProSpec Recombinant Protein for CTSS
    Cloud-Clone Corp. Proteins for CTSS 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005764lysosome NAS--
    GO:0016020membrane IEA--
    GO:0036021endolysosome lumen TAS--
    GO:0043202lysosomal lumen TAS--

    CTSS for ontologies           About GeneDecksing



    CTSS Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CTSS
    R&D Systems Antibodies for CTSS (Cathepsin S)
    OriGene Antibodies for CTSS
    OriGene Custom Antibody Services for CTSS
    GenScript Custom Superior Antibodies Services for CTSS
    Novus Biologicals CTSS Antibodies
    Abcam antibodies for CTSS
    Cloud-Clone Corp. Antibodies for CTSS 
    ThermoFisher Antibodies for CTSS
    LSBio Antibodies in human, mouse, rat for CTSS 

    Assay Products for CTSS: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CTSS
    R&D Systems ELISAs for CTSS (Cathepsin S)         (see all)
    GenScript CTSS-Activity-based Protease Assay for Compound Screening
    Enzo Life Sciences assays for CTSS
    Cloud-Clone Corp. ELISAs for CTSS 
    Cloud-Clone Corp. CLIAs for CTSS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CTS: Cathepsins

    5/6 InterPro protein domains (see all 6):
     IPR013128 Peptidase_C1A
     IPR025661 Pept_asp_AS
     IPR000169 Pept_cys_AS
     IPR013201 Prot_inhib_I29
     IPR025660 Pept_his_AS

    Graphical View of Domain Structure for InterPro Entry P25774

    ProtoNet protein and cluster: P25774

    2 Blocks protein domains:
    IPB000668 Papain cysteine protease (C1) family signature
    IPB013201 Proteinase inhibitor I29


    UniProtKB/Swiss-Prot: CATS_HUMAN, P25774
    Similarity: Belongs to the peptidase C1 family


    CTSS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATS_HUMAN, P25774
    Function: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II
    molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and
    cathepsin N
    Catalytic activity: Similar to cathepsin L, but with much less activity on Z-Phe-Arg- -NHMec, and more activity on
    the Z-Val-Val-Arg- -Xaa compound

         Genatlas biochemistry entry for CTSS:
    cathepsin S,lysosomal cysteine proteinase,expressed in spleen,heart and lung,papain superfamily,specifically
    involved in MHCII-associated chain processing and peptide loading

         Enzyme Numbers (IUBMB): EC 3.4.22.271 2 EC 3.4.222

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity TAS1373132
    GO:0008233peptidase activity ----
    GO:0008234cysteine-type peptidase activity ----
         
    CTSS for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CTSS:
     Cell cycle / mitosis defect  Decreased viability of wild-ty 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ctss):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  muscle  respiratory system  skeleton 

    CTSS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CTSS: Ctsstm1Eae Ctsstm1Hap

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CTSS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTSS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTSS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTSS 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTSS
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CTSS:
    hsa-miR-203 hsa-miR-370 hsa-miR-576-5p hsa-miR-520d-5p hsa-miR-561 hsa-miR-524-5p hsa-miR-32* hsa-miR-4282
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CTSS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CTSS
    Sirion Biotech Customized adenovirus for overexpression of CTSS

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CTSS (see all 8)
    OriGene ORF clones in mouse, rat for CTSS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CTSS (NM_004079)
    Sino Biological Human cDNA Clone for CTSS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSS
    Sirion Biotech Customized lentivirus for stable overexpression of CTSS 
                         Customized lentivirus expression plasmids for stable overexpression of CTSS 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CTSS
    Search LifeMap BioReagents cell lines for CTSS
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CTSS About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    2Collagen biosynthesis and modifying enzymes
    Collagen formation0.74
    Extracellular matrix organization0.39
    Assembly of collagen fibrils and other multimeric structures0.65
    3TRAF6 Mediated Induction of proinflammatory cytokines
    Toll-Like Receptors Cascades0.87
    4Antigen processing: Ubiquitination & Proteasome degradation
    Class I MHC mediated antigen processing & presentation0.83
    5CDK-mediated phosphorylation and removal of Cdc6
    Antigen processing-Cross presentation0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CTSS
        Immune response Antigen presentation by MHC class II


    2 GeneGo (Thomson Reuters) Pathways for CTSS
        Immune response Antigen presentation by MHC class II
    Bacterial infections in CF airways


    5/12        Reactome Pathways for CTSS (see all 12)
        Endosomal/Vacuolar pathway
    Antigen processing-Cross presentation
    Assembly of collagen fibrils and other multimeric structures
    Toll-Like Receptors Cascades
    Adaptive Immune System


    4         Kegg Pathways  (Kegg details for CTSS):
        Lysosome
    Phagosome
    Antigen processing and presentation
    Tuberculosis


    CTSS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTSS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for CTSS (P257743 ENSP000003579814) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CST5P283253, ENSP000003071324I2D: score=2 STRING: ENSP00000307132
    PLCG1P191743, ENSP000002440074I2D: score=2 STRING: ENSP00000244007
    SERPINB3P295083, ENSP000002837524I2D: score=2 STRING: ENSP00000283752
    SERPINB4P485943, ENSP000003434454I2D: score=1 STRING: ENSP00000343445
    CST3P010343, ENSP000003661244I2D: score=2 STRING: ENSP00000366124
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002250adaptive immune response IEP15196205
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--
    GO:0006508proteolysis IEA--

    CTSS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for CTSS:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTSS (CATS)

    10/12 DrugBank Compounds for CTSS (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide-- --target--17139284 17016423 10592235
    Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide-- --target--17139284 17016423 10592235
    Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide-- --target--17139284 17016423
    (1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE-- --target--10592235
    2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL-- --target--10592235
    N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE-- --target--10592235
    N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE-- --target--10592235
    N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide-- --target--10592235
    N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide-- --target--10592235
    N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDE-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about CTSS / CATS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CTSS gene (2 alternative transcripts): 
    NM_001199739.1  NM_004079.4  

    Unigene Cluster for CTSS:

    Cathepsin S
    Hs.181301  [show with all ESTs]
    Unigene Representative Sequence: NM_004079
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368985(uc001evn.3 uc010pcj.2) ENST00000472977 ENST00000607427
    ENST00000448301 ENST00000483930 ENST00000480760

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTSS
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CTSS:
    hsa-miR-203 hsa-miR-370 hsa-miR-576-5p hsa-miR-520d-5p hsa-miR-561 hsa-miR-524-5p hsa-miR-32* hsa-miR-4282
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CTSS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSS
    Clone
    Products:
         
    OriGene clones in human, mouse for CTSS (see all 8)
    OriGene ORF clones in mouse, rat for CTSS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CTSS (NM_004079)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSS
    Sirion Biotech Customized lentivirus for stable overexpression of CTSS 
                         Customized lentivirus expression plasmids for stable overexpression of CTSS 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CTSS
    OriGene qSTAR qPCR primer pairs in human, mouse for CTSS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTSS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSS

    Additional mRNA sequence: 

    AK024855.1 AK226095.1 AK301472.1 AK314482.1 BC002642.2 CR541676.1 M86553.1 M90696.1 
    S93414.1 

    21 DOTS entries:

    DT.100881531  DT.100881528  DT.447092  DT.95327167  DT.121386657  DT.101976026  DT.100881533  DT.100696184 
    DT.121386672  DT.100036139  DT.100881522  DT.451535  DT.86859484  DT.92437887  DT.97847226  DT.100881525 
    DT.121386669  DT.121386670  DT.95327165  DT.95327185  DT.121386681 

    24/328 AceView cDNA sequences (see all 328):

    AV716038 AI419485 AA911728 BU626629 AA317010 AI242415 AA411619 BQ006623 
    BQ053160 AA825451 AA814186 AJ705984 AI702418 AA694163 BM969156 AW515235 
    AA367455 AW515534 CR612707 AI472109 BQ220905 T27597 BX116242 CR607339 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CTSS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
    SP1:                                      -                 -                                 
    SP2:                                      -                                                   
    SP3:                                                                                          
    SP4:                          -     -     -                                                   
    SP5:                                                                                -         


    ECgene alternative splicing isoforms for CTSS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTSS expression in normal human tissues (normalized intensities)      CTSS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTAAAAAA
    CTSS Expression
    About this image


    CTSS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived early endothelial progenitor cells
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain

    See CTSS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTSS

    SOURCE GeneReport for Unigene cluster: Hs.181301
        SABiosciences Expression via Pathway-Focused PCR Arrays including CTSS: 
              Nephrotoxicity in human mouse rat
              Cancer Drug Targets in human mouse rat
              Antiviral Response in human mouse rat
              Autophagy in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CTSS
    OriGene qSTAR qPCR primer pairs in human, mouse for CTSS
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTSS
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSS
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CTSS gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctss1 , 5 cathepsin S1, 5 81.22(n)1
    75.54(a)1
      3 (40.74 cM)5
    130401  NM_021281.21  NP_067256.31 
     955267865 
    chicken
    (Gallus gallus)
    Aves CTSS1 cathepsin S 66.67(n)
    67.99(a)
      425657  NM_001031345.1  NP_001026516.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTSS6
    --
    Uncharacterized protein
    64(a)
    45(a)
    1 ↔ 1
    possible ortholog
    GL343862.1(16639-38667)
    GL344400.1(465-12183)
    African clawed frog
    (Xenopus laevis)
    Amphibia ctss-prov2 cathepsin S 77.02(n)    BC056059.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054668.12   -- 72.5(n)   393398  BC054668.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cp13 protein catabolism cathepsin L 50(a)
    (best of 4)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea cpl-13 cathepsin-like protease 47(a)
    (best of 2)
      V(16595339-16597937)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons XBCP31 xylem bark cysteine peptidase 3 51.03(n)
    44.86(a)
      837517  NM_100859.2  NP_563855.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05083001 hypothetical protein 49.89(n)
    43.45(a)
      4339265  NM_001062529.1  NP_001055994.1 


    ENSEMBL Gene Tree for CTSS (if available)
    TreeFam Gene Tree for CTSS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTSS gene
    TINAG2  CTSF2  CTSO2  CTSW2  CTSV2  CTSK2  CTSB2  CTSH2  
    CTSC2  TINAGL12  CTSZ2  CTSL2  
    8 SIMAP similar genes for CTSS using alignment to 1 protein entry:     CATS_HUMAN:
    CTSK    CTSL    CTSL2    CTSL1    CTSH    CTSF
    CTSO    CTSW

    CTSS for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/638 SNPs in CTSS are shown (see all 638)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1827305831,2
    C--150702217(+) CACCTC/TGGGAG 2 -- ds50010--------
    rs120953481,2
    C--150702264(+) agaccG/Cgcccg 2 -- ds50012Minor allele frequency- C:0.00NA 4
    rs1922670291,2
    --150702269(+) CGCCCC/GGCCAA 2 -- ds50010--------
    rs75408741,2
    C,F,H--150702663(+) agattA/Cgcaag 2 -- ds500119Minor allele frequency- C:0.39NS EA NA CSA WA 2338
    rs1852779731,2
    C--150702694(+) TTAATA/G/TTAAGT 4 -- ut310--------
    rs11368081,2
    C,F,H--150702717(-) tggagC/Gccctc 2 -- ut3112Minor allele frequency- G:0.34MN NS EA NA CSA WA 962
    rs1181048831,2
    C,F--150702736(+) TAAAGG/ACCCAA 2 -- ut311Minor allele frequency- A:0.03EA 120
    rs563883451,2
    C,F--150702769(+) TTTTTG/ATAGTA 2 -- ut311Minor allele frequency- A:0.50NA 2
    rs559609431,2
    C--150703035(+) CAGGC-/AGAAGGTC 2 -- cds10--------
    rs563635481,2
    C--150703037(+) GGCAG-/AAGGTCAG 2 -- cds10--------

    HapMap Linkage Disequilibrium report for CTSS (150702672 - 150738433 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CTSS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1542672CNV Deletion17803354
    esv2717818CNV Deletion23290073
    esv1299298CNV Deletion17803354
    nsv437169CNV Loss16327808
    nsv872417CNV Loss21882294
    nsv872419CNV Loss21882294
    nsv872418CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CTSS
    DNA2.0 Custom Variant and Variant Library Synthesis for CTSS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 116845    OMIM disorders: --

    20/36 diseases for CTSS (see all 36):    About MalaCards
    cercarial dermatitis    pycnodysostosis    inverted papilloma    pulmonary emphysema
    soft tissue sarcoma    morbid obesity    papilloma    prostate cancer, progression of
    coronary heart disease    herpes simplex    down syndrome    obesity
    aortic aneurysm    osteoarthritis    myopathy    dermatitis
    multiple sclerosis    astrocytoma    cervical cancer    atherosclerosis

    4 diseases from the University of Copenhagen DISEASES database for CTSS:
    Cancer     Arthritis     Cercarial dermatitis     Atherosclerosis

    CTSS for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CTSS
    Human Genome Epidemiology (HuGE) Navigator: CTSS (14 documents)

    Export disorders for CTSS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTSS gene, integrated from 9 sources (see all 109):
    (articles sorted by number of sources associating them with CTSS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. (PubMed id 1373132)1, 2, 3 Shi G.-P.... Chapman H.A. (1992)
    2. CTSS promoter -25G/A: not a risk factor for CHD in Ch inese. (PubMed id 19593952)1, 4, 9 Sun A....Ge J. (2009)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PubMed id 19336475)1, 4 Drenos F....Hingorani A.D. (2009)
    5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    6. Cathepsin S genotypes are associated with Apo-A1 and HDL-cholesterol in lean and obese French populations. (PubMed id 18565099)1, 4 Spielmann N....Clement K. (2008)
    7. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    8. Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers. (PubMed id 17622942)1, 4 Grossman I....Miller A. (2007)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. Pharmacogenomics of responsiveness to interferon IFN-beta treatment in multiple sclerosis: a genetic screen of 100 type I interferon-inducible genes. (PubMed id 16338279)1, 4 Cunningham S....Vandenbroeck K. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1520 HGNC: 2545 AceView: CTSS Ensembl:ENSG00000163131 euGenes: HUgn1520
    ECgene: CTSS Kegg: 1520 H-InvDB: CTSS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTSS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CTSS gene:
    Search GeneIP for patents involving CTSS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore small molecules (inhibitor) for CTSS
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CTSS
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CTSS (Cathepsin S)   Browse Cell Culture Products  
     ELISAs for CTSS (Cathepsin S)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for CTSS (Cathepsin S)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for CTSS (Cathepsin S)  
     OriGene Antibodies for CTSS   OriGene RNAi products in human, mouse, rat for CTSS  
     OriGene qPCR primer pairs and template standards for CTSS   OriGene Protein Over-expression Lysate for CTSS  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CTSS  
     OriGene qSTAR qPCR primer pairs in human, mouse for CTSS   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CTSS   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CTSS   OriGene Custom Protein Services for CTSS  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTSS
     QIAGEN SeqTarget long-range PCR primers for resequencing CTSS
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSS
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSS
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSS
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSS
     GenScript Custom Purified and Recombinant Proteins Services for CTSS GenScript cDNA clones with any tag delivered in your preferred vector for CTSS
     GenScript CTSS-Activity-based typehere Assay for Compound Screening GenScript Custom Superior Antibodies Services for CTSS
     GenScript Custom overexpressing Cell Line Services for CTSS CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CTSS promoter
     Search Chromatin IP Primers for CTSS
     RT2 qPCR Primer Assay in human, mouse, rat CTSS
     GNC Network for CTSS
     SABiosciences PCR Arrays including human, mouse, rat CTSS
     Search Tocris compounds for CTSS (CATS)
     Proteins and Antibodies for CTSS
     Cell Lysates for CTSS
     cDNA Clones for CTSS
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Proteins for CTSS
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CTSS antibodies
     CTSS proteins
     CTSS lysates
     Antibodies for CTSS
     See all of Abcam's Antibodies, Kits and Proteins for CTSS
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CTSS




     Proteins for CTSS
     Antibodies for CTSS
     ELISAs for CTSS
     CLIAs for CTSS
     Search LifeMap BioReagents cell lines for CTSS
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSS
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CTSS
     SwitchGear Promoter luciferase reporter plasmids for CTSS
     ThermoFisher Antibodies for CTSS
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSS
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CTSS
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTSS
    Customized:
     lentivirus for stable overexpression of CTSS
     lentivirus expression plasmids for stable overexpression of CTSS
     adenovirus for overexpression of CTSS
     LSBio Antibodies in human, mouse, rat for CTSS
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CTSS gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4