Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CTSS Gene

Aliases for CTSS Gene

  • Cathepsin S 2 3
  • EC 4 64
  • EC 3.4.22 64

External Ids for CTSS Gene

Summaries for CTSS Gene

Entrez Gene Summary for CTSS Gene

  • The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for CTSS Gene

CTSS (Cathepsin S) is a Protein Coding gene. Diseases associated with CTSS include cercarial dermatitis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Degradation of the extracellular matrix. GO annotations related to this gene include cysteine-type endopeptidase activity. An important paralog of this gene is CTSW.

UniProtKB/Swiss-Prot for CTSS Gene

  • Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N

Gene Wiki entry for CTSS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSS Gene

Genomics for CTSS Gene

Genomic Location for CTSS Gene

150,730,196 bp from pter
150,765,957 bp from pter
35,762 bases
Minus strand

Genomic View for CTSS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTSS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSS Gene

Regulatory Elements for CTSS Gene

Proteins for CTSS Gene

  • Protein details for CTSS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathepsin S
    Protein Accession:
    Secondary Accessions:
    • B4DWC9
    • D3DV05
    • Q5T5I0
    • Q6FHS5
    • Q9BUG3

    Protein attributes for CTSS Gene

    331 amino acids
    Molecular mass:
    37496 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CTSS Gene

    Alternative splice isoforms for CTSS Gene


neXtProt entry for CTSS Gene

Proteomics data for CTSS Gene at MOPED

Post-translational modifications for CTSS Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn104

Other Protein References for CTSS Gene

Domains for CTSS Gene

Gene Families for CTSS Gene

  • CTS :Cathepsins


  • Belongs to the peptidase C1 family.:
    • P25774
genes like me logo Genes that share domains with CTSS: view

Function for CTSS Gene

Molecular function for CTSS Gene

GENATLAS Biochemistry: cathepsin S,lysosomal cysteine proteinase,expressed in spleen,heart and lung,papain superfamily,specifically involved in MHCII-associated chain processing and peptide loading
UniProtKB/Swiss-Prot CatalyticActivity: Similar to cathepsin L, but with much less activity on Z-Phe-Arg- -NHMec, and more activity on the Z-Val-Val-Arg- -Xaa compound
UniProtKB/Swiss-Prot Function: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N

Enzyme Numbers (IUBMB) for CTSS Gene

Gene Ontology (GO) - Molecular Function for CTSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IPI 22952693
GO:0004197 cysteine-type endopeptidase activity IDA 22952693
GO:0005518 collagen binding IDA 22952693
GO:0008233 peptidase activity --
GO:0008234 cysteine-type peptidase activity --
genes like me logo Genes that share ontologies with CTSS: view
genes like me logo Genes that share phenotypes with CTSS: view

Animal Models for CTSS Gene

MGI Knock Outs for CTSS:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CTSS Gene

Localization for CTSS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSS Gene


Subcellular locations from

Jensen Localization Image for CTSS Gene COMPARTMENTS Subcellular localization image for CTSS gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
endosome 4
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
mitochondrion 2
nucleus 2
plasma membrane 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CTSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005764 lysosome IDA 15196205
GO:0016020 membrane IEA --
GO:0036021 endolysosome lumen TAS --
genes like me logo Genes that share ontologies with CTSS: view

Pathways for CTSS Gene

genes like me logo Genes that share pathways with CTSS: view

Gene Ontology (GO) - Biological Process for CTSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002250 adaptive immune response IEP 15196205
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS --
GO:0006508 proteolysis IDA 22864553
genes like me logo Genes that share ontologies with CTSS: view

Transcripts for CTSS Gene

Unigene Clusters for CTSS Gene

Cathepsin S:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTSS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
SP1: - -
SP2: -
SP4: - - -
SP5: -

Relevant External Links for CTSS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSS Gene

mRNA expression in normal human tissues for CTSS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSS Gene

This gene is overexpressed in Whole Blood (25.9) and Spleen (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTSS Gene

SOURCE GeneReport for Unigene cluster for CTSS Gene Hs.181301

genes like me logo Genes that share expressions with CTSS: view

Orthologs for CTSS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTSS 36
  • 99.5 (n)
  • 99.09 (a)
  • 99 (a)
(Bos Taurus)
Mammalia CTSS 36
  • 87.11 (n)
  • 83.69 (a)
  • 84 (a)
(Canis familiaris)
Mammalia CTSS 36
  • 88.82 (n)
  • 87.92 (a)
  • 86 (a)
(Mus musculus)
Mammalia Ctss 36
  • 80.97 (n)
  • 74.02 (a)
Ctss 16
Ctss 37
  • 72 (a)
(Monodelphis domestica)
Mammalia CTSS 37
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia CTSS 37
  • 73 (a)
(Rattus norvegicus)
Mammalia Ctss 36
  • 81.45 (n)
  • 77.67 (a)
(Gallus gallus)
Aves CTSS 36
  • 66.67 (n)
  • 67.99 (a)
  • 68 (a)
(Anolis carolinensis)
Reptilia CTSS 37
  • 64 (a)
African clawed frog
(Xenopus laevis)
Amphibia ctss-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ctss 36
  • 67.98 (n)
  • 62.31 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8503 36
(Danio rerio)
Actinopterygii -- 36
ctssb.1 36
  • 62.26 (n)
  • 61.01 (a)
ctssb.1 37
  • 59 (a)
ctssb.2 37
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cp1 38
  • 50 (a)
26-29kD-proteinase 38
  • 35 (a)
CG11459 38
  • 37 (a)
CG4847 38
  • 38 (a)
(Caenorhabditis elegans)
Secernentea R09F10.1 38
  • 32 (a)
cpl-1 38
  • 47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G11320 36
  • 51.52 (n)
  • 46.85 (a)
Species with no ortholog for CTSS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSS Gene

Gene Tree for CTSS (if available)
Gene Tree for CTSS (if available)

Paralogs for CTSS Gene

Paralogs for CTSS Gene

genes like me logo Genes that share paralogs with CTSS: view

Variants for CTSS Gene

Sequence variations from dbSNP and Humsavar for CTSS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1059603 -- 150,755,125(-) TTTGA(C/T)GAGTT intron-variant, missense, reference
rs1059604 - 150,751,927(-) TGGTG(A/T)CTCTC missense, reference
rs1059605 -- 150,750,100(-) TATGG(C/G/T)AGAGA reference, synonymous-codon
rs1134067 -- 150,748,699(-) gaggc(A/C)aaatc intron-variant
rs1134068 -- 150,748,657(-) ttaca(A/G)ttagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTSS Gene

Variant ID Type Subtype PubMed ID
nsv872417 CNV Loss 21882294
nsv872418 CNV Gain 21882294
nsv872419 CNV Loss 21882294
esv2717818 CNV Deletion 23290073
esv1299298 CNV Deletion 17803354
esv1542672 CNV Deletion 17803354
nsv437169 CNV Loss 16327808

Relevant External Links for CTSS Gene

HapMap Linkage Disequilibrium report

Disorders for CTSS Gene

(1) MalaCards Diseases for CTSS Gene

Search for CTSS Gene in MalaCards »

(4) University of Copenhagen DISEASES for CTSS Gene

Relevant External Links for CTSS

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CTSS: view

No data available for UniProtKB/Swiss-Prot for CTSS Gene

Publications for CTSS Gene

  1. CTSS promoter -25G/A: not a risk factor for CHD in Chinese. (PMID: 19593952) Sun A. … Ge J. (Acta Cardiol 2009) 3 23 49
  2. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. (PMID: 1373132) Shi G.-P. … Chapman H.A. (J. Biol. Chem. 1992) 2 3 4
  3. Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S. (PMID: 1377692) Wiederanders B. … Peters C. (J. Biol. Chem. 1992) 3 4
  4. Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. (PMID: 8157683) Shi G.-P. … Chapman H.A. (J. Biol. Chem. 1994) 3 4
  5. Three-dimensional structures of the cysteine proteases cathepsins K and S deduced by knowledge-based modelling and active site characteristics. (PMID: 9876921) Fengler A. … Brandt W. (Protein Eng. 1998) 3 4

Products for CTSS Gene

  • Addgene plasmids for CTSS

Sources for CTSS Gene

Back to Top