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Aliases for CTSS Gene

Aliases for CTSS Gene

  • Cathepsin S 2 3 5
  • EC 3.4.22.27 4 61
  • EC 3.4.22 61

External Ids for CTSS Gene

Previous GeneCards Identifiers for CTSS Gene

  • GC01M148546
  • GC01M146449
  • GC01M147477
  • GC01M147919
  • GC01M147515
  • GC01M148969
  • GC01M122080

Summaries for CTSS Gene

Entrez Gene Summary for CTSS Gene

  • The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for CTSS Gene

CTSS (Cathepsin S) is a Protein Coding gene. Diseases associated with CTSS include Mandibular Cancer and Cercarial Dermatitis. Among its related pathways are G-protein signaling N-RAS regulation pathway and Immune System. GO annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CTSK.

UniProtKB/Swiss-Prot for CTSS Gene

  • Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

Gene Wiki entry for CTSS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSS Gene

Genomics for CTSS Gene

Regulatory Elements for CTSS Gene

Enhancers for CTSS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F150609 1.1 FANTOM5 ENCODE 20.8 +153.2 153171 7.4 PKNOX1 ARID4B SIN3A YY1 SLC30A9 ZNF143 FOS SP3 JUNB MXD4 HORMAD1 MCL1 CTSS ARNT GOLPH3L VPS72 CDC42SE1 LYSMD1 GABPB2 VPS45
GH01F150763 0.7 FANTOM5 ENCODE 19.9 +1.0 972 3.0 TBP HDAC1 PKNOX1 WRNIP1 GTF3C2 POLR3A ETV6 FOS CEBPB USF2 HORMAD1 CTSS SETDB1 PRPF3 GOLPH3L SF3B4 UBE2D3P3 ARNT MRPL9 RPS10P6
GH01F150557 0.4 ENCODE 11.3 +196.7 196653 23.1 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC HORMAD1 SETDB1 GOLPH3L SF3B4 CTSK PRPF3 UBE2D3P3 CYCSP51 VPS45 GABPB2
GH01F150793 0.2 Ensembl 11.2 -27.4 -27382 0.7 HDAC1 CBX3 PKNOX1 NFRKB ZNF175 POLR2A ADNP EED ETV6 ZNF584 HORMAD1 CTSS UBE2D3P3 GC01P150780 LOC100132571
GH01F150320 1.4 FANTOM5 ENCODE 8.1 +444.2 444202 2.4 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A YBX1 DMAP1 GABPB2 PRPF3 ADAMTSL4 SETDB1 CYCSP51 MRPS21 MCL1 BOLA1 LYSMD1 UBE2D3P3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CTSS on UCSC Golden Path with GeneCards custom track

Promoters for CTSS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000544808 1757 3601 TBP HDAC1 PKNOX1 WRNIP1 RAD21 GTF3C2 POLR3A ETV6 FOS CEBPB

Genomic Location for CTSS Gene

Chromosome:
1
Start:
150,730,196 bp from pter
End:
150,765,957 bp from pter
Size:
35,762 bases
Orientation:
Minus strand

Genomic View for CTSS Gene

Genes around CTSS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSS Gene

Proteins for CTSS Gene

  • Protein details for CTSS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25774-CATS_HUMAN
    Recommended name:
    Cathepsin S
    Protein Accession:
    P25774
    Secondary Accessions:
    • B4DWC9
    • D3DV05
    • Q5T5I0
    • Q6FHS5
    • Q9BUG3

    Protein attributes for CTSS Gene

    Size:
    331 amino acids
    Molecular mass:
    37496 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for CTSS Gene

    Alternative splice isoforms for CTSS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTSS Gene

Post-translational modifications for CTSS Gene

  • Glycosylation at Asn 104
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSS Gene

Antibody Products

Protein Products

Assay Products

  • Enzo Life Sciences assays for CTSS
  • Cloud-Clone Corp Assay Kits for CTSS

Domains & Families for CTSS Gene

Gene Families for CTSS Gene

Suggested Antigen Peptide Sequences for CTSS Gene

Graphical View of Domain Structure for InterPro Entry

P25774

UniProtKB/Swiss-Prot:

CATS_HUMAN :
  • Belongs to the peptidase C1 family.
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSS: view

Function for CTSS Gene

Molecular function for CTSS Gene

GENATLAS Biochemistry:
cathepsin S,lysosomal cysteine proteinase,expressed in spleen,heart and lung,papain superfamily,specifically involved in MHCII-associated chain processing and peptide loading
UniProtKB/Swiss-Prot CatalyticActivity:
Similar to cathepsin L, but with much less activity on Z-Phe-Arg- -NHMec, and more activity on the Z-Val-Val-Arg- -Xaa compound.
UniProtKB/Swiss-Prot Function:
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

Enzyme Numbers (IUBMB) for CTSS Gene

Gene Ontology (GO) - Molecular Function for CTSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IPI 22952693
GO:0004197 cysteine-type endopeptidase activity IDA,TAS --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005518 collagen binding IDA 22952693
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with CTSS: view
genes like me logo Genes that share phenotypes with CTSS: view

Animal Models for CTSS Gene

MGI Knock Outs for CTSS:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CTSS

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSS Gene

Localization for CTSS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSS Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTSS Gene COMPARTMENTS Subcellular localization image for CTSS gene
Compartment Confidence
endosome 5
extracellular 5
lysosome 5
vacuole 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CTSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0005764 lysosome IEA,IDA 15196205
GO:0036021 endolysosome lumen TAS --
GO:0043202 lysosomal lumen TAS --
genes like me logo Genes that share ontologies with CTSS: view

Pathways & Interactions for CTSS Gene

genes like me logo Genes that share pathways with CTSS: view

Gene Ontology (GO) - Biological Process for CTSS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002250 adaptive immune response IEP 15196205
GO:0006508 proteolysis IEA,IDA 22864553
GO:0006955 immune response TAS 8157683
GO:0010447 response to acidic pH IDA 22864553
genes like me logo Genes that share ontologies with CTSS: view

No data available for SIGNOR curated interactions for CTSS Gene

Drugs & Compounds for CTSS Gene

(16) Drugs for CTSS Gene - From: DrugBank, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE Experimental Pharma Target 0
2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL Experimental Pharma Target 0
Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide Experimental Pharma Target 0
Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide Experimental Pharma Target 0
Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide Experimental Pharma Target 0

(3) ApexBio Compounds for CTSS Gene

Compound Action Cas Number
Cathepsin Inhibitor 1 Cathepsin inhibitor 225120-65-0
Cathepsin S inhibitor Blocks MHCII antigen presentation 1373215-15-6
E-64 Cysteine protease inhibitor,irriversible 66701-25-5
genes like me logo Genes that share compounds with CTSS: view

Transcripts for CTSS Gene

Unigene Clusters for CTSS Gene

Cathepsin S:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CTSS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTSS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
SP1: - -
SP2: -
SP3:
SP4: - - -
SP5: -

Relevant External Links for CTSS Gene

GeneLoc Exon Structure for
CTSS
ECgene alternative splicing isoforms for
CTSS

Expression for CTSS Gene

mRNA expression in normal human tissues for CTSS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSS Gene

This gene is overexpressed in Whole Blood (x25.9) and Spleen (x4.3).

Protein differential expression in normal tissues from HIPED for CTSS Gene

This gene is overexpressed in Monocytes (12.2), Peripheral blood mononuclear cells (9.0), Spleen (6.3), and Nasal epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTSS Gene



NURSA nuclear receptor signaling pathways regulating expression of CTSS Gene:

CTSS

SOURCE GeneReport for Unigene cluster for CTSS Gene:

Hs.181301
genes like me logo Genes that share expression patterns with CTSS: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CTSS Gene

Orthologs for CTSS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTSS 34 35
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia CTSS 34 35
  • 88.82 (n)
cow
(Bos Taurus)
Mammalia CTSS 34 35
  • 87.11 (n)
rat
(Rattus norvegicus)
Mammalia Ctss 34
  • 81.45 (n)
mouse
(Mus musculus)
Mammalia Ctss 34 16 35
  • 80.97 (n)
oppossum
(Monodelphis domestica)
Mammalia CTSS 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTSS 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTSS 34 35
  • 66.67 (n)
lizard
(Anolis carolinensis)
Reptilia CTSS 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctss 34
  • 67.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia ctss-prov 34
zebrafish
(Danio rerio)
Actinopterygii ctssb.1 34 35
  • 62.26 (n)
ctssb.2 35
  • 58 (a)
OneToMany
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8503 34
fruit fly
(Drosophila melanogaster)
Insecta Cp1 36
  • 50 (a)
CG4847 36
  • 38 (a)
CG11459 36
  • 37 (a)
26-29kD-proteinase 36
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea cpl-1 36
  • 47 (a)
R09F10.1 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G11320 34
  • 51.52 (n)
Species where no ortholog for CTSS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSS Gene

ENSEMBL:
Gene Tree for CTSS (if available)
TreeFam:
Gene Tree for CTSS (if available)

Paralogs for CTSS Gene

Variants for CTSS Gene

Sequence variations from dbSNP and Humsavar for CTSS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10556231 -- 150,739,663(+) TGTCT(-/CAA)CAACA intron-variant
rs1059603 -- 150,755,125(-) TTTGA(C/T)GAGTT intron-variant, reference, missense
rs1059604 -- 150,751,927(-) TGGTG(A/T)CTCTC reference, missense
rs1059605 -- 150,750,100(-) TATGG(C/G/T)AGAGA reference, synonymous-codon
rs10609824 -- 150,743,508(+) ATATA(-/TA)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTSS Gene

Variant ID Type Subtype PubMed ID
esv1299298 CNV deletion 17803354
esv1542672 CNV deletion 17803354
esv2717818 CNV deletion 23290073
esv3587511 CNV loss 21293372
nsv1006838 CNV gain 25217958
nsv1008381 CNV gain 25217958
nsv1076858 CNV deletion 25765185
nsv1144404 CNV deletion 24896259
nsv437169 CNV loss 16327808
nsv952803 CNV deletion 24416366

Variation tolerance for CTSS Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.13; 93.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTSS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTSS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSS Gene

Disorders for CTSS Gene

MalaCards: The human disease database

(7) MalaCards diseases for CTSS Gene - From: DISEASES

Disorder Aliases PubMed IDs
mandibular cancer
  • malignant neoplasm of inferior maxilla
cercarial dermatitis
  • cutaneous schistosomiasis
non-suppurative otitis media
  • nonsuppurative otitis media
corneal dystrophy, subepithelial mucinous
  • subepithelial mucinous corneal dystrophy
jaw cancer
  • jaw neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search CTSS in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTSS

Genetic Association Database (GAD)
CTSS
Human Genome Epidemiology (HuGE) Navigator
CTSS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTSS
genes like me logo Genes that share disorders with CTSS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSS Gene

Publications for CTSS Gene

  1. CTSS promoter -25G/A: not a risk factor for CHD in Chinese. (PMID: 19593952) Sun A. … Ge J. (Acta Cardiol 2009) 3 22 46 64
  2. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. (PMID: 1373132) Shi G.-P. … Chapman H.A. (J. Biol. Chem. 1992) 2 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PMID: 19336475) Drenos F. … Hingorani A.D. (Hum. Mol. Genet. 2009) 3 46 64
  5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr J.M. … Deary I.J. (Mech. Ageing Dev. 2008) 3 46 64

Products for CTSS Gene

Sources for CTSS Gene

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