CTSS Gene
protein-coding GIFtS: 68
GCID: GC01M150702
|
|
cathepsin S
| |
Aliases
for CTSS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cathepsin S1 2 | | EC 3.4.22.273 8 | | EC 3.4.228 |
Export aliases for CTSS gene to outside databasesPrevious GC identifers: GC01M148546 GC01M146449 GC01M147477 GC01M147919 GC01M147515 GC01M148969 GC01M122080 |
Summaries
for CTSS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CTSS:
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that mayparticipate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. Theencoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively splicedtranscript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Dec 2010)
UniProtKB/Swiss-Prot: CATS_HUMAN, P25774Function: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules.The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N
Gene Wiki entry for CTSS (Cathepsin S)
|
Genomic Views
for CTSS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CTSS gene promoter:
STAT5B TBP STAT5A IRF-1 Evi-1 AREB6 Ik-2 Ik-1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CTSS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21CTSS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M150702: view genomic region
(about GC identifiers)
Start:
|
150,702,551 bp from pter |
End:
|
150,738,433 bp from pter |
Size:
|
35,883 bases |
Orientation:
|
minus strand |
|
Proteins
for CTSS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CATS_HUMAN, P25774 (See
protein sequence)Recommended Name: Cathepsin S precursor Size: 331 amino acids; 37496 Da
Subunit: Monomer
Subcellular location: Lysosome
6/30 PDB 3D structures from  and Proteopedia  for CTSS (see all 30):1BXF (3D)
1GLO (3D)
1MS6 (3D)
1NPZ (3D)
1NQC (3D)
2C0Y (3D)
Secondary accessions: B4DWC9 D3DV05 Q5T5I0 Q6FHS5 Q9BUG3Alternative splicing: 2 isoforms: P25774-1 P25774-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CTSS: NX_P25774
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P25774
4/14 DME Specific Peptides for CTSS (P25774) (see all 14)
CTSS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001186668.1 NP_004070.3
ENSEMBL proteins: ENSP00000357981 ENSP00000408414 Reactome Protein details: P25774
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
CTSS for ontologies About GeneDecksing
CTSS Antibody Products:
Assay Products for CTSS: |
Protein
Domains /
Families
for CTSS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CTSS for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P25774ProtoNet protein and cluster: P25774 2 Blocks protein families: IPB000668 Papain cysteine protease (C1) family signature IPB013201 Proteinase inhibitor I29
UniProtKB/Swiss-Prot: CATS_HUMAN, P25774Similarity: Belongs to the peptidase C1 family |
Function
for CTSS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CATS_HUMAN, P25774Function: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules.The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin NCatalytic activity: Similar to cathepsin L, but with much less activity on Z-Phe-Arg- -NHMec, and more activity on theZ-Val-Val-Arg- -Xaa compound Genatlas biochemistry entry for CTSS:cathepsin S,lysosomal cysteine proteinase,expressed in spleen,heart and lung,papain superfamily,specifically involvedin MHCII-associated chain processing and peptide loading
Enzyme Numbers (IUBMB): EC 3.4.22.271 2 EC 3.4.222
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTSS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTSS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CTSS (NM_004079) | |  | Sino Biological Human cDNA Clone for CTSS | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTSS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSS |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CTSS for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CTSS:
Animal Models:
Mouse knock-outs for CTSS: Ctsstm1Eae Ctsstm1Hap
10 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ctss):
CTSS for phenotypes About GeneDecksing
|
Pathways & Interactions
for CTSS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | Collagen formation | | | 3 | Immune response_Antigen presentation by MHC class II | | | 4 | MHC class II antigen presentation | | | 5 | Tuberculosis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CTSS
2  GeneGo (Thomson Reuters) Pathways for CTSS
5/12 
Reactome Pathways for CTSS (see all 12)
4 
Kegg Pathways (Kegg details for CTSS):
CTSS for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTSS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/33 Interacting proteins for CTSS (P257743 ENSP000003579814) via UniProtKB, MINT, STRING, and/or I2D (see all 33)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002250 | adaptive immune response |
IEP | 15196205 | | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I |
TAS | -- | | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent |
TAS | -- | | GO:0006508 | proteolysis |
IEA | -- | | GO:0006955 | immune response |
TAS | 8157683 |
CTSS for ontologies About GeneDecksing
|
Drugs & Compounds
for CTSS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CTSS
10/12 DrugBank Compounds for CTSS (see all 12) About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-Amide | -- | -- | target | -- | 17139284 17016423 10592235 | | Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]Amide | -- | -- | target | -- | 17139284 17016423 10592235 | | Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-Amide | -- | -- | target | -- | 17139284 17016423 | | (1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATE | -- | -- | target | -- | 10592235 | | 2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL | -- | -- | target | -- | 10592235 | | N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDE | -- | -- | target | -- | 10592235 | | N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDE | -- | -- | target | -- | 10592235 | | N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide | -- | -- | target | -- | 10592235 | | N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamide | -- | -- | target | -- | 10592235 | | N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDE | -- | -- | target | -- | 10592235 |
Search CenterWatch for drugs/clinical trials and news about CTSS / CATS
|
Transcripts
for CTSS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CTSS gene (2 alternative transcripts): NM_001199739.1 NM_004079.4 Unigene Cluster for CTSS: Cathepsin S Hs.181301 [show with all ESTs]Unigene Representative Sequence: NM_0040795 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368985(uc001evn.3 uc010pcj.2) ENST00000472977 ENST00000483930
ENST00000480760 ENST00000448301
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTSS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTSS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CTSS (NM_004079) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTSS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSS |
Additional cDNA sequence: AK024855.1 AK226095.1 AK301472.1 AK314482.1 BC002642.2 CR541676.1 M86553.1 M90696.1 S93414.1 21 DOTS entries: DT.100881531 DT.100881528 DT.447092 DT.95327167 DT.121386657 DT.101976026 DT.100881533 DT.100696184 DT.121386672 DT.100036139 DT.100881522 DT.451535 DT.86859484 DT.92437887 DT.97847226 DT.100881525 DT.121386669 DT.121386670 DT.95327165 DT.95327185 DT.121386681 24/328 AceView cDNA sequences (see all 328): AI419485 AJ705984 AI925850 AI281840 AV716038 BQ220905 CA425538 AI471234 AA825451 CD368265 AI446052 AA694163 AA563663 CR612707 AA367455 AI733867 AI242415 BU626629 CA308597 AA317010 AA411619 AA911728 AL548051 AW515117
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CTSS About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | |
ECgene alternative splicing isoforms for CTSS
|
Expression
for CTSS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CTSS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTAAAAAA
About this image
See CTSS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTSS
SOURCE GeneReport for Unigene cluster: Hs.181301
SABiosciences Expression via Pathway-Focused PCR Arrays including CTSS:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTSS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTSS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSS |
Orthologs
for CTSS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CTSS gene from 8/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CTSS1 |
cathepsin S |
66.67(n)
67.99(a) |
|
425657 NM_001031345.1 NP_001026516.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CTSS6 |
-- |
62(a) |
1 ↔ 1 |
GL343862.1(18139-36017) |
African clawed frog
(Xenopus laevis) |
Amphibia |
ctss-prov2 |
cathepsin S |
77.02(n) |
|
BC056059.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC054668.12 |
-- |
72.5(n) |
|
393398 BC054668.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Cp13 |
protein catabolism cathepsin L |
50(a)
(best of 4) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
cpl-13 |
cathepsin-like protease |
47(a)
(best of 2) |
|
V(16595339-16597937) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
XBCP31 |
xylem bark cysteine peptidase 3 |
51.03(n)
44.86(a) |
|
837517 NM_100859.2 NP_563855.1 |
rice
(Oryza sativa) |
Liliopsida |
Os05g05083001 |
hypothetical protein |
49.89(n)
43.45(a) |
|
4339265 NM_001062529.1 NP_001055994.1 |
ENSEMBL Gene Tree for CTSS (if available)
TreeFam Gene Tree for CTSS (if available) |
Paralogs
for CTSS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CTSS gene
- TINAG2 CTSL12 CTSF2 CTSO2 CTSW2 CTSK2 CTSB2 CTSL22
- CTSH2 CTSC2 TINAGL12 CTSZ2
8 SIMAP similar genes for CTSS using alignment to 1 protein entry: CATS_HUMAN:CTSK CTSL CTSL2 CTSL1 CTSH CTSF
CTSO CTSW
CTSS for paralogs About GeneDecksing
|
Genomic Variants
for CTSS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CTSS (150702551 - 150738433 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CTSS
2 Indels: 23969 23968 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTSS |
|
Disorders
/ Diseases
for CTSS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CTSS for disorders About GeneDecksing
OMIM gene information: 116845
OMIM disorders: --
20/36  diseases for CTSS (see all 36): About MalaCardscercarial dermatitis inverted papilloma soft tissue sarcoma pycnodysostosis
coronary heart disease morbid obesity pulmonary emphysema herpes simplex
emphysema papilloma squamous cell carcinoma rheumatoid arthritis
prostate cancer, progression of down syndrome multiple sclerosis myopathy
prostate cancer obesity sarcoma cervical cancer
4 diseases from the University of Copenhagen DISEASES database for CTSS:Cancer Arthritis Cercarial dermatitis Atherosclerosis Human Genome Epidemiology (HuGE) Navigator: CTSS (14 documents)
Export disorders for CTSS gene to outside databases
|
Publications
for CTSS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CTSS gene, integrated from 9 sources (see all 104):
(articles sorted by number of sources associating them with CTSS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease. (PubMed id 1373132)1, 2, 3 Shi G.-P.... Chapman H.A. (1992)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Structure of a Cys25-->Ser mutant of human cathepsin S. (PubMed id 11856830)1, 2 Turkenburg J.P.... Williams D.H. (2002)
- Three-dimensional structures of the cysteine proteases cathepsins K and S deduced by knowledge-based modelling and active site characteristics. (PubMed id 9876921)1, 2 Fengler A. and Brandt W. (1998)
- Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. (PubMed id 8157683)1, 2 Shi G.-P.... Chapman H.A. (1994)
- Phylogenetic conservation of cysteine proteinases. Cloning and expression of a cDNA coding for human cathepsin S. (PubMed id 1377692)1, 2 Wiederanders B....Peters C. (1992)
- CTSS promoter -25G/A: not a risk factor for CHD in Ch inese. (PubMed id 19593952)1, 9 Sun A....Ge J. (2009)
- Human cathepsin S gene (CTSS) promoter -25G/A polymorphism. (PubMed id 10721671)1, 9 Cao H. and Hegele R.A. (2000)
- Cleavage of nidogen-1 by cathepsin S impairs its bindi ng to basement membrane partners. (PubMed id 22952693)1 Sage J....Lecaille F. (2012)
|
External Searches for CTSS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CTSS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CTSS gene
(According to HUGE)
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Specialized Databases showing CTSS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for CTSS | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CTSS gene:
Search GeneIP for patents involving CTSS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CTSS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for CTSS | | OriGene shRNA RFP for CTSS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTSS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTSS | | | OriGene Protein Over-expression Lysate for CTSS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CTSS | | OriGene 3'-UTR Clone for CTSS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTSS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTSS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CTSS | | OriGene Custom Protein Services for CTSS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTSS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTSS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSS |
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| | | | Search Tocris compounds for CTSS |
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 | | | CTSS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSS |
|  |  |  | | | | ThermoFisher Antibodies for CTSS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSS |
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