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Aliases for CTSO Gene

Aliases for CTSO Gene

  • Cathepsin O 2 3 5
  • CTSO1 3 4
  • EC 3.4.22.42 4

External Ids for CTSO Gene

Previous HGNC Symbols for CTSO Gene

  • CTSO1

Previous GeneCards Identifiers for CTSO Gene

  • GC04M157734
  • GC04M157274
  • GC04M157422
  • GC04M157202
  • GC04M157064
  • GC04M156845
  • GC04M152584

Summaries for CTSO Gene

Entrez Gene Summary for CTSO Gene

  • The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTSO Gene

CTSO (Cathepsin O) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CTSF.

UniProtKB/Swiss-Prot for CTSO Gene

  • Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

Gene Wiki entry for CTSO Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSO Gene

Genomics for CTSO Gene

Regulatory Elements for CTSO Gene

Enhancers for CTSO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G155952 1.2 ENCODE dbSUPER 17.4 0.0 -34 3.4 FOXA2 SIN3A DMAP1 ZNF48 YY1 CBX5 ZNF207 MIER2 REST ZNF518A CTSO FTH1P21
GH04G156109 0.8 Ensembl ENCODE 15 -157.0 -156999 2.7 CTCF HLF TEAD4 CHD7 CTSO GC04P156132 PIR40160
GH04G156020 0.9 ENCODE 11.7 -67.4 -67448 0.9 TBP ELF3 PKNOX1 FOXA2 ATF1 ARNT MLX SIN3A ARID4B FEZF1 CTSO PIR40160 GC04P156132
GH04G155973 1 ENCODE dbSUPER 7 -20.3 -20260 1.4 PKNOX1 TEAD4 RELA CBX5 RELB IKZF2 CREM CHD2 MTA2 DPF2 CTSO FTH1P21
GH04G155959 0.5 ENCODE dbSUPER 11.2 -6.7 -6670 2.2 CTSO FTH1P21
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CTSO on UCSC Golden Path with GeneCards custom track

Promoters for CTSO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000175211 417 1401 DMAP1 ZNF48 CBX5 ZNF207 MIER2 REST TBX21 ZNF518A KAT8 ZNF610

Genomic Location for CTSO Gene

Chromosome:
4
Start:
155,924,118 bp from pter
End:
155,953,917 bp from pter
Size:
29,800 bases
Orientation:
Minus strand

Genomic View for CTSO Gene

Genes around CTSO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSO Gene

Proteins for CTSO Gene

  • Protein details for CTSO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43234-CATO_HUMAN
    Recommended name:
    Cathepsin O
    Protein Accession:
    P43234

    Protein attributes for CTSO Gene

    Size:
    321 amino acids
    Molecular mass:
    35958 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTSO Gene

Post-translational modifications for CTSO Gene

  • Glycosylation at isoforms=62 and isoforms=105
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSO Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTSO Gene

Domains & Families for CTSO Gene

Gene Families for CTSO Gene

Suggested Antigen Peptide Sequences for CTSO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43234

UniProtKB/Swiss-Prot:

CATO_HUMAN :
  • Belongs to the peptidase C1 family.
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSO: view

Function for CTSO Gene

Molecular function for CTSO Gene

GENATLAS Biochemistry:
cathepsin O,lysosomal cysteine proteinase,papain superfamily,ubiquitously expressed
UniProtKB/Swiss-Prot CatalyticActivity:
The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.
UniProtKB/Swiss-Prot Function:
Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.

Enzyme Numbers (IUBMB) for CTSO Gene

Gene Ontology (GO) - Molecular Function for CTSO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS 7929457
GO:0008233 peptidase activity IEA --
GO:0008234 cysteine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CTSO: view
genes like me logo Genes that share phenotypes with CTSO: view

Animal Models for CTSO Gene

MGI Knock Outs for CTSO:
  • Ctso tm2b(KOMP)Wtsi

Animal Model Products

  • Taconic Biosciences Mouse Models for CTSO

CRISPR Products

miRNA for CTSO Gene

miRTarBase miRNAs that target CTSO

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CTSO

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSO Gene

Localization for CTSO Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSO Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTSO gene
Compartment Confidence
lysosome 5
extracellular 3

Gene Ontology (GO) - Cellular Components for CTSO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005764 lysosome IBA,IEA --
genes like me logo Genes that share ontologies with CTSO: view

Pathways & Interactions for CTSO Gene

genes like me logo Genes that share pathways with CTSO: view

Pathways by source for CTSO Gene

2 KEGG pathways for CTSO Gene

Gene Ontology (GO) - Biological Process for CTSO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis TAS 7929457
GO:0051603 proteolysis involved in cellular protein catabolic process IBA --
genes like me logo Genes that share ontologies with CTSO: view

No data available for SIGNOR curated interactions for CTSO Gene

Drugs & Compounds for CTSO Gene

(1) Drugs for CTSO Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Papain Inhibitor Pharma Inhibitor of peptidase activity of Papain 0

(1) ApexBio Compounds for CTSO Gene

Compound Action Cas Number
Papain Inhibitor Inhibitor of peptidase activity of Papain 70195-20-9
genes like me logo Genes that share compounds with CTSO: view

Drug Products

Transcripts for CTSO Gene

mRNA/cDNA for CTSO Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(138) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTSO Gene

Cathepsin O:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CTSO

Alternative Splicing Database (ASD) splice patterns (SP) for CTSO Gene

No ASD Table

Relevant External Links for CTSO Gene

GeneLoc Exon Structure for
CTSO
ECgene alternative splicing isoforms for
CTSO

Expression for CTSO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTSO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTSO Gene

This gene is overexpressed in NK cells (19.8), Islet of Langerhans (14.6), Prostate (12.3), and CD8 Tcells (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CTSO Gene



NURSA nuclear receptor signaling pathways regulating expression of CTSO Gene:

CTSO

SOURCE GeneReport for Unigene cluster for CTSO Gene:

Hs.75262

mRNA Expression by UniProt/SwissProt for CTSO Gene:

P43234-CATO_HUMAN
Tissue specificity: Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle.

Evidence on tissue expression from TISSUES for CTSO Gene

  • Intestine(4)
genes like me logo Genes that share expression patterns with CTSO: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTSO Gene

Orthologs for CTSO Gene

This gene was present in the common ancestor of animals.

Orthologs for CTSO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTSO 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia CTSO 34 35
  • 88.04 (n)
cow
(Bos Taurus)
Mammalia CTSO 34 35
  • 82.76 (n)
mouse
(Mus musculus)
Mammalia Ctso 34 16 35
  • 80.16 (n)
oppossum
(Monodelphis domestica)
Mammalia CTSO 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 26 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CTSO 34 35
  • 74.18 (n)
lizard
(Anolis carolinensis)
Reptilia CTSO 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctso 34
  • 66.79 (n)
zebrafish
(Danio rerio)
Actinopterygii ctso 34 35
  • 61.82 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6991 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002720 34
  • 46.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6347 35
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R07E3.1 36 35
  • 33 (a)
Y40H7A.10 35
  • 24 (a)
OneToMany
R09F10.1 35
  • 22 (a)
OneToMany
Y113G7B.15 35
  • 22 (a)
OneToMany
tag-329 35
  • 22 (a)
OneToMany
Y51A2D.8 35
  • 20 (a)
OneToMany
Y51A2D.1 35
  • 19 (a)
OneToMany
Species where no ortholog for CTSO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSO Gene

ENSEMBL:
Gene Tree for CTSO (if available)
TreeFam:
Gene Tree for CTSO (if available)

Paralogs for CTSO Gene

Paralogs for CTSO Gene

(8) SIMAP similar genes for CTSO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTSO: view

Variants for CTSO Gene

Sequence variations from dbSNP and Humsavar for CTSO Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs11303235 -- 155,950,857(+) ACCCC(A/C/G)ACACC intron-variant
rs11383821 -- 155,950,006(+) TTTTT(-/A)AAGGA intron-variant
rs140877092 -- 155,948,374(+) GCCTT(-/TGTGTG)TGTGT intron-variant
rs141198252 -- 155,948,374(+) GCCTT(-/TGTGTGTG)TGTGT intron-variant
rs200000569 -- 155,948,381(+) TGTGT(G/T)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTSO Gene

Variant ID Type Subtype PubMed ID
esv274871 CNV loss 21479260
esv3569758 CNV loss 25503493
esv3575777 CNV gain 25503493
esv999516 CNV insertion 20482838
nsv1026581 CNV gain 25217958
nsv1029122 CNV gain 25217958
nsv262 CNV insertion 15895083
nsv437447 CNV loss 16327808
nsv4564 CNV insertion 18451855
nsv480081 CNV novel sequence insertion 20440878
nsv830121 CNV gain 17160897

Variation tolerance for CTSO Gene

Residual Variation Intolerance Score: 43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 36.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTSO Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTSO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSO Gene

Disorders for CTSO Gene

Relevant External Links for CTSO

Genetic Association Database (GAD)
CTSO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTSO

No disorders were found for CTSO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTSO Gene

Publications for CTSO Gene

  1. Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO). (PMID: 9790772) SantamarA-a I. … LA^pez-OtA-n C. (Genomics 1998) 2 3 22 64
  2. First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. (PMID: 19786962) Roeske D. … Schulte-KAPrne G. (Mol. Psychiatry 2011) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues. (PMID: 7929457) Velasco G. … Lopez-Otin C. (J. Biol. Chem. 1994) 3 4 64
  5. Prognostic impact of a single-nucleotide polymorphism near the CTSO gene in hormone receptor-positive breast cancer patients. (PMID: 26482374) Hato Y. … Toyama T. (Int. J. Clin. Oncol. 2016) 3 64

Products for CTSO Gene

Sources for CTSO Gene

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