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CTSO Gene

protein-coding   GIFtS: 55
GCID: GC04M156845

Cathepsin O


(Previous symbol: CTSO1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cathepsin O1 2
CTSO11 2 3
EC 3.4.22.423

External Ids:    HGNC: 25421   Entrez Gene: 15192   Ensembl: ENSG000002560437   OMIM: 6005505   UniProtKB: P432343   

Export aliases for CTSO gene to outside databases

Previous GC identifers: GC04M157734 GC04M157274 GC04M157422 GC04M157202 GC04M157064 GC04M152584


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTSO Gene:
The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic
enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to
degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was
abolished by an inhibitor of cyteine proteinase. (provided by RefSeq, Jul 2008)

GeneCards Summary for CTSO Gene:
CTSO (cathepsin O) is a protein-coding gene. Diseases associated with CTSO include pycnodysostosis, and malaria. GO annotations related to this gene include cysteine-type endopeptidase activity. An important paralog of this gene is CTSF.

UniProtKB/Swiss-Prot: CATO_HUMAN, P43234
Function: Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover

Gene Wiki entry for CTSO (Cathepsin O) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CTSO
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTSO promoter sequence
   Search Chromatin IP Primers for CTSO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTSO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.1   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q32.1

CTSO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSO gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M156845:  view genomic region     (about GC identifiers)

Start:
156,845,270 bp from pter      End:
156,875,069 bp from pter
Size:
29,800 bases      Orientation:
minus strand

1 alternative location:
Chr4-,NW_003315914 88,741-118,513     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CATO_HUMAN, P43234 (See protein sequence)
Recommended Name: Cathepsin O precursor  
Size: 321 amino acids; 35958 Da

Explore the universe of human proteins at neXtProt for CTSO: NX_P43234

Explore proteomics data for CTSO at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn62, Asn105
  • Modification sites at PhosphoSitePlus

  • See CTSO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001325.1  
    ENSEMBL proteins: 
     ENSP00000414904  
    Reactome Protein details: P43234

    CTSO Human Recombinant Protein Products:

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    Novus Biologicals CTSO Protein
    Novus Biologicals CTSO Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTSO

    CTSO Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CTSO (Cathepsin O)
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    Novus Biologicals CTSO Antibodies
    Abcam antibodies for CTSO
    Cloud-Clone Corp. Antibodies for CTSO
    ThermoFisher Antibody for CTSO
    LSBio Antibodies in human, mouse, rat for CTSO

    CTSO Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CTSO
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CTSO
    Cloud-Clone Corp. CLIAs for CTSO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CTS: Cathepsins

    4 InterPro protein domains:
     IPR013128 Peptidase_C1A
     IPR000169 Pept_cys_AS
     IPR025660 Pept_his_AS
     IPR000668 Peptidase_C1A_C

    Graphical View of Domain Structure for InterPro Entry P43234

    ProtoNet protein and cluster: P43234

    1 Blocks protein domain: IPB000668 Papain cysteine protease (C1) family signature

    UniProtKB/Swiss-Prot: CATO_HUMAN, P43234
    Similarity: Belongs to the peptidase C1 family


    CTSO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATO_HUMAN, P43234
    Function: Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover
    Catalytic activity: The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including
    Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec

         Genatlas biochemistry entry for CTSO:
    cathepsin O,lysosomal cysteine proteinase,papain superfamily,ubiquitously expressed

         Enzyme Number (IUBMB): EC 3.4.22.421

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity TAS7929457
    GO:0008234cysteine-type peptidase activity ----
         
    CTSO for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTSO
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTSO
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTSO

    miRNA
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    Block miRNA regulation of human, mouse, rat CTSO using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CTSO:
    hsa-miR-578 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidCTSO 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CTSO
    Predesigned siRNA for gene silencing in human, mouse, rat CTSO

    Gene Editing
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    OriGene ORF clones in mouse, rat for CTSO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTSO (NM_001334)
    Sino Biological Human cDNA Clone for CTSO
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSO

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CTSO 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CATO_HUMAN, P43234: Lysosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    vacuole5
    cytosol1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IEA--

    CTSO for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTSO About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2MHC class II antigen presentation
    MHC class II antigen presentation
    3Lysosome
    Lysosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CTSO
        MHC class II antigen presentation


    1 Kegg Pathway  (Kegg details for CTSO):
        Lysosome


    CTSO for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTSO
    Interactions:

        Search GeneGlobe Interaction Network for CTSO

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS7929457

    CTSO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTSO (CATO)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CTSO gene: 
    NM_001334.2  

    Unigene Cluster for CTSO:

    Cathepsin O
    Hs.75262  [show with all ESTs]
    Unigene Representative Sequence: NM_001334
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000433477(uc003ipg.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CTSO using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CTSO:
    hsa-miR-578 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidCTSO 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CTSO
    Predesigned siRNA for gene silencing in human, mouse, rat CTSO
    Clone
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    OriGene clones in human, mouse for CTSO (see all 6)
    OriGene ORF clones in mouse, rat for CTSO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTSO (NM_001334)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSO
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CTSO
    OriGene qSTAR qPCR primer pairs in human, mouse for CTSO
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTSO
      QuantiTect SYBR Green Assays in human, mouse, rat CTSO
      QuantiFast Probe-based Assays in human, mouse, rat CTSO

    Additional mRNA sequence: 

    AK300112.1 AK308323.1 AK312354.1 BC049206.1 X77383.1 

    4 DOTS entries:

    DT.452446  DT.121218744  DT.100809660  DT.40191333 

    Selected AceView cDNA sequences (see all 138):

    AI033423 AA024431 N81036 AI634956 BU735518 AI200651 AI522027 BX113588 
    AA767784 BM129303 AI889600 AI708625 AA922992 AI523707 AI247114 AA024432 
    BQ002824 AI348405 AA885288 AI480391 BM998065 AI635547 AI247006 AW305190 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTSO expression in normal human tissues (normalized intensities)      CTSO embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGCAGTA
    CTSO Expression
    About this image


    CTSO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Metencephalon
    CTSO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTSO Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75262

    UniProtKB/Swiss-Prot: CATO_HUMAN, P43234
    Tissue specificity: Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while
    low levels seen in thymus and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CTSO gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctso1 , 5 cathepsin O1, 5 80.16(n)1
    76.82(a)1
      3 (35.97 cM)5
    2294451  NM_177662.21  NP_808330.11 
     819326015 
    chicken
    (Gallus gallus)
    Aves CTSO1 cathepsin O 74.18(n)
    72.54(a)
      422410  NM_001031129.1  NP_001026300.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTSO6
    cathepsin O
    67(a)
    1 ↔ 1
    5(129429266-129445037)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ctso1 cathepsin O 66.79(n)
    62.77(a)
      100496370  XM_002933473.2  XP_002933519.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ctso1 cathepsin O 61.82(n)
    58.91(a)
      567333  XM_690625.5  XP_695717.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG63476
    --
    21(a)
    many ↔ many
    2R(9723926-9726869)
    worm
    (Caenorhabditis elegans)
    Secernentea R07E3.13 cysteine proteinase 33(a)   X(10374605-10376330)   --


    ENSEMBL Gene Tree for CTSO (if available)
    TreeFam Gene Tree for CTSO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTSO gene
    CTSF2  CTSW2  CTSV2  CTSK2  CTSS2  CTSH2  CTSC2  CTSZ2  
    CTSL2  
    8 SIMAP similar genes for CTSO using alignment to 1 protein entry:     CATO_HUMAN:
    CTSS    CTSF    CTSK    CTSL    CTSV    CTSW
    CTSH    CTSL1

    CTSO for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTSO (see all 750)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440353541,2
    --156844788(+) TAAATA/GCAGGG 1 -- ds50010--------
    rs1473741391,2
    --156844949(+) GGAGGC/TAGGTA 1 -- ds50010--------
    rs1484363391,2
    --156845034(+) TGATTC/GCATAA 1 -- ds50010--------
    rs780429191,2
    C--156845084(+) AAGGAA/CATTTT 1 -- ds50010--------
    rs1916809071,2
    --156845099(+) GGGGGA/TGGTGG 1 -- ds50010--------
    rs782421931,2
    F--156845144(+) AAACAC/GTGAGG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1841466631,2
    C--156845253(+) AAGCCA/GTACAC 1 -- ds50010--------
    rs1491130911,2
    --156845414(+) CACAT-/AGAAA 
    GTCAGCGA
    AGAAA
    1 -- ut310--------
    rs1873256811,2
    --156845436(+) CAAACG/TAGACA 1 -- ut310--------
    rs1505121261,2
    --156845556(+) CTTTTC/TGGATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CTSO (156845270 - 156875069 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CTSO:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv999516CNV Insertion20482838
    nsv4564CNV Insertion18451855
    nsv262CNV Insertion15895083
    nsv437447CNV Loss16327808
    esv274871CNV Loss21479260
    nsv830121CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CTSO
    DNA2.0 Custom Variant and Variant Library Synthesis for CTSO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600550    OMIM disorders: --

    2 diseases for CTSO:    About MalaCards
    pycnodysostosis    malaria


    CTSO for disorders           About GeneDecksing

    Genetic Association Database (GAD): CTSO

    Export disorders for CTSO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTSO gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CTSO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO). (PubMed id 9790772)1, 3, 9 SantamarA-a I....LA^pez-OtA-n C. (Genomics 1998)
    2. First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. (PubMed id 19786962)1, 4 Roeske D....Schulte-KAPrne G. (Mol. Psychiatry 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues. (PubMed id 7929457)1, 2 Velasco G.... Lopez-Otin C. (J. Biol. Chem. 1994)
    5. Molecular insight into propeptide-protein interactions in cathepsins L and O. (PubMed id 23009386)1 Reif M.M....Oostenbrink C. (Biochemistry 2012)
    6. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (J. Proteome Res. 2012)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2. (PubMed id 7805878)1 Shi G.-P....Weiss S.J. (FEBS Lett. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1519 HGNC: 2542 AceView: CTSO Ensembl:ENSG00000256043 euGenes: HUgn1519
    ECgene: CTSO Kegg: 1519 H-InvDB: CTSO

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTSO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTSO gene:
    Search GeneIP for patents involving CTSO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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