CTSL2 Gene

Aliases
for CTSL2 gene

Previous GC identifers: GC09M090620 GC09M091538 GC09M093252 GC09M095174 GC09M096874 GC09M098834 GC09M069395

Summaries
for CTSL2 gene

Genomic Views
for CTSL2 gene

RefSeq DNA sequence:

NC_000009.11  NC_018920.1  NT_008470.19  

SwitchGear Promoter luciferase reporter plasmid: CTSL2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSL2

CTSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M099794:  view genomic region     (about GC identifiers)

Proteins
for CTSL2 gene

3 PDB 3D structures from and Proteopedia for CTSL2:

1FH0 (3D)        3H6S (3D)        3KFQ (3D)    

Explore the universe of human proteins at neXtProt for CTSL2: NX_O60911

Post-translational modifications:

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	R&D Systems Recombinant & Natural Proteins for CTSL2 (Cathepsin V)
	Enzo Life Sciences proteins for CTSL2
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CTSL2 OriGene Custom Protein Services for CTSL2
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	Novus Biologicals CTSL2 Protein Novus Biologicals CTSL2 Lysates
	Sino Biological Recombinant Protein for CTSL2
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	Uscn Proteins for CTSL2

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CTSL2
	R&D Systems Antibodies for CTSL2 (Cathepsin V)
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	Novus Biologicals CTSL2 Antibodies
	Abcam antibodies for CTSL2
	Uscn Antibodies for CTSL2
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	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CTSL2 (Cathepsin V)         (see all)
	GenScript CTSL2-Activity-based Protease Assay for Compound Screening
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CTSL2

Protein Domains /
Families
for CTSL2 gene

ProtoNet protein and cluster: O60911

Function
for CTSL2 gene

miRNA Products:		OriGene 3'-UTR Clone: CTSL2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTSL2
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate CTSL2 (see all 20):
		hsa-miR-320a hsa-miR-140-5p hsa-miR-1226 hsa-miR-4328 hsa-miR-500a hsa-miR-223 hsa-miR-890 hsa-miR-924
		SwitchGear 3'UTR luciferase reporter plasmid: CTSL2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTSL2 OriGene shRNA RFP: CTSL2 OriGene siRNA: CTSL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSL2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CTSL2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTSL2 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTSL2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CTSL2 (NM_001201575)
		Sino Biological Human cDNA Clone for CTSL2
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CTSL2
		Search LifeMap BioReagents cell lines for CTSL2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSL2

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

Pathways & Interactions
for CTSL2 gene

	Super-pathway	contained gene-specific pathways
1	Collagen formation	Collagen formation 1.00 Extracellular matrix organization 0.54 Assembly of collagen fibrils and other multimeric structures 0.65
2	Immune System	Immune System 1.00 Adaptive Immune System 0.59
3	Degradation of the extracellular matrix	Degradation of the extracellular matrix 1.00 Activation of Matrix Metalloproteinases 0.40
4	MHC class II antigen presentation	MHC class II antigen presentation 1.00
5	Lysosome	Lysosome 1.00

1 BioSystems Pathway for CTSL2

Endochondral Ossification

5/8        Reactome Pathways for CTSL2

	Assembly of collagen fibrils and other multimeric structures
	Adaptive Immune System
	Collagen formation
	Activation of Matrix Metalloproteinases
	Extracellular matrix organization

1         Kegg Pathway  (Kegg details for CTSL2)

Lysosome

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

Drugs & Compounds
for CTSL2 gene

Transcripts
for CTSL2 gene

Expression
for CTSL2 gene

CTSL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGGGGAAA

Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Definitive endoderm-like cells (A scalable, suspensi...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTSL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTSL2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSL2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSL2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSL2

Orthologs
for CTSL2 gene

Paralogs
for CTSL2 gene

Paralogs for CTSL2 gene

TINAG²  CTSL1²  CTSF²  CTSO²  CTSW²  CTSK²  CTSB²  CTSS²  

CTSH²  CTSC²  TINAGL1²  CTSZ²  

8 SIMAP similar genes for CTSL2 using alignment to 1 protein entry:     CATL2_HUMAN:

CTSL1    CTSL    CTSS    CTSK    CTSH    CTSF

CTSO    CTSW

CTSL2 for paralogs           About GeneDecksing

Genomic Variants
for CTSL2 gene

10/234 NCBI SNPs in CTSL2 are shown (see all 234)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1895919031,2		--	99791494(+)	TTCACG/TCCATT	2	--	int1		0	--	--	--	--
rs1416518161,2		--	99791572(+)	TTTGTA/CTTTTT	2	--	int1		0	--	--	--	--
rs1813841281,2		--	99791573(+)	TTGTAC/TTTTTA	2	--	int1		0	--	--	--	--
rs1461528431,2		--	99791599(+)	CACCAC/TGTTAG	2	--	int1		0	--	--	--	--
rs1390320871,2		--	99791875(+)	GCTGCA/TCAAGG	2	--	int1		0	--	--	--	--
rs64778311,2	C,F,A,H,	--	99791912(+)	TCAAGG/AATCAA	2	--	int1		25		NS EA NA WA CSA	2353
rs758648931,2		--	99792056(+)	CAAGTC/TATGTG	2	--	ut31		1		NA	120
rs1859212461,2		--	99792155(+)	ATACAC/TGAATA	2	--	ut31		0	--	--	--	--
rs101237541,2	C,F,A,H,	--	99792208(+)	ATGTGT/CTGCAC	2	--	ut31		21		NS EA NA WA CSA	2322
rs101237571,2	C,F,A,	--	99792249(+)	CCATAT/CAGCCT	2	--	ut31		9		NA WA CSA EA	369

HapMap Linkage Disequilibrium report for CTSL2 (99794937 - 99801925 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CTSL2
     2 CNVs: 4646 52897

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTSL2

DNA2.0 Custom Variant and Variant Library Synthesis for CTSL2

Disorders / Diseases
for CTSL2 gene

19 diseases for CTSL2

2 Novoseek disease relationships for CTSL2 gene    About this table

Publications
for CTSL2 gene

PubMed articles for CTSL2 gene, integrated from 9 sources (see all 55): (articles sorted by number of sources associating them with CTSL2)

Utopia: connect your pdf to the dynamic world of online information

1. Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization. (PubMed id 10029531)^{1, 2, 3, 9} Bromme D....Mehler E. (1999)
2. Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas. (PubMed id 9563472)^{1, 2, 3, 9} Santamaria I....Lopez-Otin C. (1998)
3. Crystal structure of human cathepsin V. (PubMed id 11027133)^{1, 2, 9} Somoza J.R.... McGrath M.E. (2000)
4. Genomic organization and chromosomal localization of the human cathepsin L2 gene. (PubMed id 10382972)^{1, 2, 9} Itoh R.... Okubo K. (1999)
5. Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium. (PubMed id 9727401)^{1, 2, 9} Adachi W.... Okubo K. (1998)
6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
8. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. (PubMed id 16565075)^{1, 9} Cheng T....Zeeuwen P.L. (2006)
9. Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. (PubMed id 15192101)^{1, 9} Yasuda Y....Bromme D. (2004)
10. Cathepsin V, but not cathepsins L, B and K, may release angiostatin-like fragments from plasminogen. (PubMed id 18163891)^{1, 9} Puzer L....Carmona A.K. (2008)

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Products
for CTSL2 gene