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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTSL1 Gene

protein-coding   GIFtS: 69
GCID: GC09P090341

cathepsin L1

(Previous name: cathepsin L )
(Previous symbol: CTSL)
 Explore 88 diseases affiliated with
CTSL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CTSL1    

Aliases
for CTSL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cathepsin L11 2     EC 3.4.22.153 8
CTSL1 2 3 5     FLJ310371
Cathepsin L1 2     CATL2
Major Excreted Protein2 3     EC 3.4.228
MEP2 3     

External Ids:    HGNC: 25371   Entrez Gene: 15142   Ensembl: ENSG000001350477   OMIM: 1168805   UniProtKB: P077113   

Export aliases for CTSL1 gene to outside databases

Previous GC identifers: GC09P089531 GC09P060166


Summaries
for CTSL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CTSL1:
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein
catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling
element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes,
including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to
proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy
and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants
have been found for this gene. (provided by RefSeq, Apr 2012)

UniProtKB/Swiss-Prot: CATL1_HUMAN, P07711
Function: Important for the overall degradation of proteins in lysosomes

summary for CTSL1:
Cathepsins are a group of lysosomal proteases that have a key role in cellular protein turnover. The term
cathepsin includes serine proteases (cathepsins A and G), aspartic proteases (cathepsin D and E) as well as
the cysteine proteases (cathepsins B, C, F, H, K, L, O, S, W and Z). Most cathepsins are endopeptidases,
with the exception of cathepsin C and Z. Cathepsins are synthesized as inactive proenzymes, glycosylated
post-translationally, and directed towards the lysosomal compartment by cellular mannose-6-phosphate
receptors. Their activity is regulated by several mechanisms including regulation of synthesis, zymogen
processing, inhibition by endogenous inhibitors (e.g. stefins and cystatins for cysteine cathepsins) and pH.
The main function of cathepsins is protein recycling within the lysosome but they are also known to be
involved in a range of other physiological, as well as pathological processes, including maturation of the
MHC class II complex, bone remodeling, keratinocyte differentiation, tumor progression and metastasis,
rheumatoid arthritis, osteoarthritis and atherosclerosis.

Gene Wiki entry for CTSL1 (Cathepsin L1)


Genomic Views
for CTSL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTSL1 gene promoter:
         TBP   p53   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CTSL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CTSL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.33   Ensembl cytogenetic band:  9q21.33   HGNC cytogenetic band: 9q21.33

CTSL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSL1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P090341:  view genomic region     (about GC identifiers)

Start:
 90,340,434 bp from pter      End:
 90,346,384 bp from pter
Size:
 5,951 bases      Orientation:
 plus strand

Proteins
for CTSL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CATL1_HUMAN, P07711 (See protein sequence)
Recommended Name: Cathepsin L1 precursor  
Size: 333 amino acids; 37564 Da
Subunit: Dimer of a heavy and a light chain linked by disulfide bonds
Subcellular location: Lysosome
6/26 PDB 3D structures from and Proteopedia for CTSL1 (see all 26):
1CJL (3D)        1CS8 (3D)        1ICF (3D)        1MHW (3D)        2NQD (3D)        2VHS (3D)    
Secondary accessions: Q6IAV1 Q96QJ0

Explore the universe of human proteins at neXtProt for CTSL1: NX_P07711

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P07711

    • 4/19 DME Specific Peptides for CTSL1 (P07711) (see all 19)
     QNLVDCS  GCNGGLM  VDWREKG  QGQCGSC 

    CTSL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001244900.1  NP_001244901.1  NP_001244902.1  NP_001903.1  NP_666023.1  

    ENSEMBL proteins: 
     ENSP00000345344   ENSP00000365061   ENSP00000340470  
    Reactome Protein details: P07711
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CTSL1 (Cathepsin L)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): CTSL1
    OriGene Protein Over-expression Lysate (see all 2): CTSL1
    OriGene Custom Protein Services for CTSL1 
    GenScript Custom Purified and Recombinant Proteins Services for CTSL1
    Novus Biologicals CTSL1 Proteins
    Novus Biologicals CTSL1 Lysates
    Sino Biological Recombinant Protein for CTSL1
    ProSpec Recombinant Protein for CTSL1
    Uscn Proteins for CTSL1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS14718574
    GO:0005634nucleus TAS--
    GO:0005764lysosome NAS--
    GO:0036021endolysosome lumen TAS--
    GO:0043202lysosomal lumen TAS--


    CTSL1 for ontologies           About GeneDecksing



    CTSL1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CTSL1
    R&D Systems Antibodies for CTSL1 (Cathepsin L)
    OriGene Antibodies: CTSL1
    OriGene Custom Antibody Services for CTSL1 
    GenScript Custom Superior Antibodies Services for CTSL1
    Novus Biologicals CTSL1 Antibodies
    Abcam antibodies for CTSL1 
    Uscn Antibodies for CTSL1
    ThermoFisher Antibodies for CTSL1

    Assay Products for CTSL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for CTSL1 (Cathepsin L)         (see all)
    GenScript CTSL1-Activity-based Protease Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CTSL1

    Protein Domains /
    Families
    for CTSL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CTSL1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR013128 Peptidase_C1A
     IPR025661 Pept_asp_AS
     IPR000169 Pept_cys_AS
     IPR013201 Prot_inhib_I29
     IPR025660 Pept_his_AS

    Graphical View of Domain Structure for InterPro Entry P07711

    ProtoNet protein and cluster: P07711

    2 Blocks protein families:
    IPB000668 Papain cysteine protease (C1) family signature
    IPB013201 Proteinase inhibitor I29


    UniProtKB/Swiss-Prot: CATL1_HUMAN, P07711
    Similarity: Belongs to the peptidase C1 family


    Function
    for CTSL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CATL1_HUMAN, P07711
    Function: Important for the overall degradation of proteins in lysosomes
    Catalytic activity: Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher
    activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity

    Enzyme Numbers (IUBMB): EC 3.4.22.151 2 EC 3.4.222

    miRNA
    Products:            		miRTarBase miRNAs that target CTSL1:
    hsa-mir-30a (MIRT005214)

    OriGene 3'-UTR Clone (see all 2): CTSL1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTSL1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CTSL1
    SwitchGear 3'UTR luciferase reporter plasmid: CTSL1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTSL1 (see all 4)
    OriGene shRNA RFP: CTSL1
    OriGene siRNA: CTSL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSL1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CTSL1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTSL1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTSL1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CTSL1 (NM_001912)
    Sino Biological Human cDNA Clone for CTSL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSL1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CTSL1
    Search LifeMap BioReagents cell lines for CTSL1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSL1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IDA14511383
    GO:0005515protein binding IPI17889653
    GO:0008234cysteine-type peptidase activity IDA8811434
    GO:0042393histone binding IDA--


    CTSL1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CTSL1:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for CTSL1: Ctsltm1Alpk Ctsltm1Cptr
         15/19 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ctsl) (see all 19):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  nervous system  other 

    CTSL1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CTSL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Innate Immune System0.46
    		Adaptive Immune System0.59
    2Collagen formation
    		Collagen formation1.00
    		Extracellular matrix organization0.54
    		Assembly of collagen fibrils and other multimeric structures0.65
    3Immune response_Antigen presentation by MHC class II
    		Immune response_Antigen presentation by MHC class II1.00
    		Immune response Antigen presentation by MHC class II0.76
    4Degradation of the extracellular matrix
    		Degradation of the extracellular matrix1.00
    		Degradation of collagen0.79
    5Endostatin degradation by cathepsins
    		Endostatin degradation by cathepsins1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CTSL1
        Immune response Antigen presentation by MHC class II


    2 GeneGo (Thomson Reuters) Pathways for CTSL1
        Immune response Antigen presentation by MHC class II
    Bacterial infections in CF airways

    5/12        Reactome Pathways for CTSL1 (see all 12)
        Endostatin degradation by cathepsins
    Assembly of collagen fibrils and other multimeric structures
    Toll-Like Receptors Cascades
    Adaptive Immune System
    Collagen formation


    4         Kegg Pathways  (Kegg details for CTSL1):
        Lysosome
    Phagosome
    Antigen processing and presentation
    Rheumatoid arthritis


    CTSL1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTSL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for CTSL1 (P077111, 2, 3 ENSP000003453444) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEDO755302, 3, ENSP000002633604MINT-8253935 I2D: score=2 STRING: ENSP00000263360
    CRELD2Q6UXH12, 3MINT-8253924 I2D: score=1 
    CSTAP010403, ENSP000002644744I2D: score=3 STRING: ENSP00000264474
    CD74P042333, ENSP000000095304I2D: score=2 STRING: ENSP00000009530
    CST3P010343, ENSP000003661244I2D: score=2 STRING: ENSP00000366124
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002250adaptive immune response IEP15196205
    GO:0006508proteolysis IDA--
    GO:0019882antigen processing and presentation TAS15196205
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--
    GO:0045087innate immune response TAS--


    CTSL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CTSL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CTSL1 for compounds           About GeneDecksing

    EMD Millipore small molecules for CTSL1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CTSL1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CalpeptinCalpain and cathepsin L inhibitor[117591-20-5]
    N-Acetyl-L-leucyl-L-leucyl-L-methionalCathepsin inhibitor[136632-32-1]
    SID 26681509Cathepsin L inhibitor[958772-66-2]

    2 DrugBank Compounds for CTSL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    BIPHENYL-4-YL-ACETALDEHYDE-- --target--10592235
    Cysteinesulfonic Acid-- --target----

    10/62 Novoseek chemical compound relationships for CTSL1 gene (see all 62)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 89.7 188 1898042 (3), 9563472 (3), 9816040 (2), 10993910 (2) (see all 99)
    n-(2,4-dinitrophenyl)ethylenediamine 81.6 3 9163334 (1), 10727410 (1), 20302511 (1)
    scca1 70.3 6 10653592 (1), 12743426 (1), 9817977 (1)
    actinidin 66.8 4 8654398 (3), 10380357 (1)
    ca 074 60 2 10600517 (1)
    leupeptin 58.1 7 20355055 (2), 7487106 (1), 2297706 (1), 7840205 (1) (see all 5)
    serine 55.6 21 1551416 (2), 9006092 (1), 10653592 (1), 17631863 (1) (see all 19)
    kininogen 55.3 9 12492488 (3), 8654398 (2), 1466282 (1), 8467916 (1) (see all 6)
    anthranilate 53.9 2 9163334 (1), 10727410 (1)
    matrigel 52.7 3 15621884 (1), 8521613 (1), 12715895 (1)

    Search CenterWatch for drugs/clinical trials and news about CTSL1 / CATL1 

    Transcripts
    for CTSL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CTSL1 gene (5 alternative transcripts): 
    NM_001257971.1  NM_001257972.1  NM_001257973.1  NM_001912.4  NM_145918.2  

    Unigene Clusters for CTSL1:

    Cathepsin L1
    Hs.731507  [show with all ESTs], Hs.731952  [show with all ESTs]
    Unigene Representative Sequences: AK055599, AL570627
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343150(uc004api.3 uc004aph.3 uc010mqh.3 uc004apl.3 uc004apk.3)
    ENST00000340342 ENST00000375894 ENST00000495822 ENST00000342020 ENST00000482054


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): CTSL1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTSL1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CTSL1
    SwitchGear 3'UTR luciferase reporter plasmid: CTSL1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTSL1 (see all 4)
    OriGene shRNA RFP: CTSL1
    OriGene siRNA: CTSL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSL1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTSL1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTSL1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): CTSL1 (NM_001912)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSL1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTSL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CTSL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSL1

    Additional cDNA sequence: X05256.1 

    24/27 DOTS entries (see all 27):

    DT.218387  DT.100040761  DT.97862169  DT.100881398  DT.101985520  DT.100881388  DT.100881419  DT.100881390 
    DT.100881389  DT.121160013  DT.100881403  DT.100881428  DT.92453710  DT.100881404  DT.100881426  DT.100881393 
    DT.100881407  DT.100881409  DT.121160017  DT.95253876  DT.100829796  DT.100837176  DT.121160083  DT.121160105 

    24/688 AceView cDNA sequences (see all 688):

    CR591819 NM_001912 BU790538 CR603622 AA329575 CR619050 CR617897 BQ378141 
    CR612043 BQ009150 CR595268 AI150759 CR623879 AI702435 CR612596 BI824623 
    CR607547 BF674281 AI709086 BQ226235 BU626777 CR603807 AI928345 AL702501 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for CTSL1 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a ·
    SP1:                                            -     -     -                       -                                                     -                     
    SP2:                                -     -     -     -     -                       -                                                     -                     
    SP3:                                -     -     -     -     -                       -                                                     -                     
    SP4:                                      -     -     -     -                       -                                                     -                     
    SP5:                                -     -     -     -     -     -     -     -     -     -                                               -                     

    ExUns: 9b ^ 10
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CTSL1

    Expression
    for CTSL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTSL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAGGAATTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CTSL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleMural Granulosa CellsOvary
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primitive gut tube-like cells (A scalable, suspensi...)

    See CTSL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTSL1

    SOURCE GeneReport for Unigene clusters: Hs.731507 Hs.731952
        SABiosciences Expression via Pathway-Focused PCR Arrays including CTSL1: 
              Cancer Drug Targets in human mouse rat
              Antiviral Response in human mouse rat
              Alzheimer's Disease in human mouse rat
              Tumor Metastasis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for CTSL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CTSL1 gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NYJ1_CHICK6
    		 Uncharacterized protein
    		 68(a)
    		 possible ortholog
    		 Z(40910626-40916030)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 62(a)
    		 possible ortholog
    		 2(40926589-40932486)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia AL879746.12   -- 75(n)    AL879746.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.265552 Danio rerio cathepsin mRNA, partial cds 76.38(n)    AF498292.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cp16
    CG114596
    (see all 4)    		 --
    		 49(a)
    35(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 2R(9848164-9855486)
    3R(1851832-1852962)
    worm
    (Caenorhabditis elegans)    		 Secernentea cpl-16
    		 CathePsin L family member (cpl-1)
    		 48(a)
    		 possible ortholog
    		 V(16592550-16595327)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G502601 putative cysteine proteinase 54.7(n)
    51.68(a)    		   835091  NM_124405.2  NP_568722.1 
    rice
    (Oryza sativa)    		 Liliopsida Os08g05569001 hypothetical protein 49.73(n)
    44.73(a)    		   4346292  NM_001069014.1  NP_001062479.1 


    ENSEMBL Gene Tree for CTSL1 (if available)
    TreeFam Gene Tree for CTSL1 (if available) 

    Paralogs
    for CTSL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTSL1 gene
    TINAG2  CTSF2  CTSO2  CTSW2  CTSK2  CTSB2  CTSL22  CTSS2  
    CTSH2  CTSC2  TINAGL12  CTSZ2  
    10 SIMAP similar genes for CTSL1 using alignment to 3 protein entries:     CATL1_HUMAN (see all proteins):
    CTSL    CTSL2    CTSL3P    CTSK    CTSS    DKFZp686B24257
    CTSH    CTSF    CTSO    CTSW

    CTSL1 for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for CTSL1 (see all 9)
    PGOHUM00000251240 PGOHUM00000251242 PGOHUM00000251245 PGOHUM00000238490 PGOHUM00000238554


    Genomic Variants
    for CTSL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/157 NCBI SNPs in CTSL1 are shown (see all 157)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1129367271,2
    		C,--90339051(+) CTCTCG/ACCCTG 5 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1497717971,2
    		--90339069(+) CTACAA/CCACCT 5 -- us2k10--------
    rs1447022861,2
    		--90339132(+) TCCTGA/GACCTC 5 -- us2k10--------
    rs1906937351,2
    		--90339194(+) ACACAA/GTTCCA 5 -- us2k10--------
    rs1395271011,2
    		--90339201(+) TCCAGA/GTATTC 5 -- us2k10--------
    rs1444587021,2
    		--90339284(+) CTCCAC/GAGAAG 5 -- us2k10--------
    rs789850721,2
    		F,--90339318(+) CGGCCG/AGGCAC 5 -- us2k11Minor allele frequency- A:0.10EA 120
    rs1466424891,2
    		--90339338(+) CACCTG/TTAATT 5 -- us2k10--------
    rs1413313001,2
    		--90339455(+) CAGGCA/GTGGTG 5 -- us2k10--------
    rs1424218331,2
    		--90339464(+) TGGTGC/TGCGCC 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for CTSL1 (90340434 - 90346384 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for CTSL1
         2 CNVs: 0129 3775
    Human Gene Mutation Database (HGMD): CTSL1

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CTSL1

    Disorders / Diseases
    for CTSL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CTSL1 for disorders           About GeneDecksing

    OMIM gene information: 116880    OMIM disorders: --

    20/88 diseases for CTSL1 (see all 88):    About MalaCards
    rheumatoid arthritis    proteinuria    osteoarthritis    ischemia
    hermansky-pudlak syndrome    arthritis    atherosclerosis    thrombotic thrombocytopenic purpura
    myopathy    dna topoisomerase i    aortic aneurysm    gingival overgrowth
    metachromatic leukodystrophy    abdominal aortic aneurysm    giant cell tumor    severe acute respiratory syndrome
    benign meningioma    pulmonary emphysema    otitis media    cutaneous malignant melanoma

    4 diseases from the University of Copenhagen DISEASES database for CTSL1:
    Fascioliasis     Clonorchiasis     Chagas disease     Paragonimiasis

    10/61 Novoseek disease relationships for CTSL1 gene (see all 61)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 41.7 39 16918298 (2), 19550400 (2), 11869092 (2), 8835762 (2) (see all 27)
    benign meningioma 41.1 1 11270551 (1)
    pulmonary emphysema 36.4 1 2365815 (1)
    tumors 34.2 104 9816040 (5), 9703780 (4), 16261157 (3), 19915865 (3) (see all 46)
    gingival overgrowth 33.5 3 12466121 (1), 15324353 (1)
    carcinoma squamous cell 31 8 12392065 (2), 19959474 (1), 7612192 (1), 12907202 (1) (see all 5)
    oral cancer 23.4 6 12907202 (2), 8985100 (1), 10987253 (1)
    glioblastoma 21.9 12 17094453 (3), 8521613 (3), 17574778 (3), 19137551 (1) (see all 5)
    cancer 21.7 42 16918298 (4), 19958782 (4), 17855659 (2), 15621884 (2) (see all 23)
    primary tumor 20.9 5 9816040 (1), 19550400 (1), 9508185 (1)


    Export disorders for CTSL1 gene to outside databases

    Publications
    for CTSL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTSL1 gene, integrated from 9 sources (see all 523):
    (articles sorted by number of sources associating them with CTSL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. (PubMed id 2835398)1, 2, 3 Joseph L.J.... Sukhatme V.P. (1988)
    2. The crystal structure of human cathepsin L complexed with E-64. (PubMed id 9141479)1, 2, 9 Fujishima A....Sugarawa T. (1997)
    3. Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment. (PubMed id 8896443)1, 2, 9 Coulombe R....Cygler M. (1996)
    4. Cloning, genomic organization, and chromosomal localization of human cathepsin L. (PubMed id 8419312)1, 3, 9 Chauhan S.S....Troen B.R. (1993)
    5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    8. Isolation and sequence of a cDNA for human pro-(cathepsin L). (PubMed id 3421948)1, 2 Gal S. and Gottesman M.M. (1988)
    9. Amino acid sequences of the human kidney cathepsins H and L. (PubMed id 3342889)1, 2 Ritonja A.... Turk V. (1988)
    10. The major ras induced protein in NIH3T3 cells is cathepsin L. (PubMed id 3550705)1, 2 Joseph L.J.... Sukhatme V.P. (1987)

    External Searches for CTSL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CTSL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1514 HGNC: 2537 AceView: CTSL Ensembl:ENSG00000135047 euGenes: HUgn1514
    ECgene: CTSL1 Kegg: 1514 H-InvDB: CTSL1

    Other Databases showing CTSL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CTSL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTSL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTSL1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CTSL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CTSL1 gene:
    Search GeneIP for patents involving CTSL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CTSL1 gene

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    About This Section

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