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CTSL Gene

protein-coding   GIFtS: 59
GCID: GC09P090352

Cathepsin L

(Previous name: cathepsin L1)
(Previous symbol: CTSL1)
  See CTSL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cathepsin L1 2 3     MEP2 3
CTSL11 2 3     EC 3.4.22.153 8
Cathepsin L11 2     CATL2
Major Excreted Protein2 3     EC 3.4.228

External Ids:    HGNC: 25371   Entrez Gene: 15142   Ensembl: ENSG000001350477   OMIM: 1168805   UniProtKB: P077113   
ORGUL members:         

Export aliases for CTSL gene to outside databases

Previous GC identifers: GC09P081384 GC09P082193 GC09P083896 GC09P085798 GC09P087570 GC09P089530


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTSL Gene:
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular
protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major
controlling element of neutrophil elastase activity. The encoded protein has been implicated in several
pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal
tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed
of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively
spliced transcript variants have been found for this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for CTSL Gene:
CTSL (cathepsin L) is a protein-coding gene. Diseases associated with CTSL include osteoarthritis, and metachromatic leukodystrophy. GO annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CTSF.

UniProtKB/Swiss-Prot: CATL1_HUMAN, P07711
Function: Important for the overall degradation of proteins in lysosomes

summary for CTSL Gene:
Cathepsins are a group of lysosomal proteases that have a key role in cellular protein turnover. The term
cathepsin includes serine proteases (cathepsins A and G), aspartic proteases (cathepsin D and E) as well as
the cysteine proteases (cathepsins B, C, F, H, K, L, O, S, W and Z). Most cathepsins are endopeptidases,
with the exception of cathepsin C and Z. Cathepsins are synthesized as inactive proenzymes, glycosylated
post-translationally, and directed towards the lysosomal compartment by cellular mannose-6-phosphate
receptors. Their activity is regulated by several mechanisms including regulation of synthesis, zymogen
processing, inhibition by endogenous inhibitors (e.g. stefins and cystatins for cysteine cathepsins) and pH.
The main function of cathepsins is protein recycling within the lysosome but they are also known to be
involved in a range of other physiological, as well as pathological processes, including maturation of the
MHC class II complex, bone remodeling, keratinocyte differentiation, tumor progression and metastasis,
rheumatoid arthritis, osteoarthritis and atherosclerosis.

Gene Wiki entry for CTSL (Cathepsin L1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CTSL
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTSL promoter sequence
   Search Chromatin IP Primers for CTSL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTSL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.33   Ensembl cytogenetic band:  9q21.33   HGNC cytogenetic band: 9q21.33

CTSL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSL gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P090352:  view genomic region     (about GC identifiers)

Start:
90,340,434 bp from pter      End:
90,346,384 bp from pter
Size:
5,951 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CATL1_HUMAN, P07711 (See protein sequence)
Recommended Name: Cathepsin L1 precursor  
Size: 333 amino acids; 37564 Da
Subunit: Dimer of a heavy and a light chain linked by disulfide bonds
Selected PDB 3D structures from and Proteopedia for CTSL (see all 28):
1CJL (3D)        1CS8 (3D)        1ICF (3D)        1MHW (3D)        2NQD (3D)        2VHS (3D)    
Secondary accessions: Q6IAV1 Q96QJ0

Explore the universe of human proteins at neXtProt for CTSL: NX_P07711

Explore proteomics data for CTSL at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn221
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CTSL (P07711) (see all 19)
     QNLVDCS  GCNGGLM  VDWREKG  QGQCGSC 


    See CTSL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001244900.1  NP_001244901.1  NP_001244902.1  NP_001903.1  NP_666023.1  

    ENSEMBL proteins: 
     ENSP00000345344   ENSP00000365061   ENSP00000340470  
    Reactome Protein details: P07711

    CTSL Human Recombinant Protein Products:

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    Novus Biologicals CTSL Proteins
    Novus Biologicals CTSL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTSL

     
    Search eBioscience for Proteins for CTSL 

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    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    CTSL Assay Products:

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    Cloud-Clone Corp. ELISAs for CTSL
    Cloud-Clone Corp. CLIAs for CTSL
    eBioscience ELISAs for CTSL:  
                        Human Cathepsin L Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CTS: Cathepsins

    Selected InterPro protein domains (see all 6):
     IPR013128 Peptidase_C1A
     IPR025661 Pept_asp_AS
     IPR000169 Pept_cys_AS
     IPR013201 Prot_inhib_I29
     IPR025660 Pept_his_AS

    Graphical View of Domain Structure for InterPro Entry P07711

    ProtoNet protein and cluster: P07711

    2 Blocks protein domains:
    IPB000668 Papain cysteine protease (C1) family signature
    IPB013201 Proteinase inhibitor I29


    UniProtKB/Swiss-Prot: CATL1_HUMAN, P07711
    Similarity: Belongs to the peptidase C1 family


    Find genes that share domains with CTSL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATL1_HUMAN, P07711
    Function: Important for the overall degradation of proteins in lysosomes
    Catalytic activity: Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher
    activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase
    activity

         Genatlas biochemistry entry for CTSL:
    cathepsin L,lysosomal cysteine proteinase,papain superfamily,ubiquitously expressed,involved in matrix degradation
    during endochondral ossification

         Enzyme Numbers (IUBMB): EC 3.4.22.151 2 EC 3.4.222

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IPI--
    GO:0004197cysteine-type endopeptidase activity IDA14511383
    GO:0005515protein binding IPI17889653
    GO:0005518collagen binding IDA--
    GO:0008234cysteine-type peptidase activity IDA8811434
         
    Find genes that share ontologies with CTSL           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CTSL:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ctsl) (see all 19):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  nervous system  other 

    Find genes that share phenotypes with CTSL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CTSL: Ctsltm1Alpk Ctsltm1Cptr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTSL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTSL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTSL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTSL

    miRNA
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    miRTarBase miRNAs that target CTSL:
    hsa-mir-30a-5p (MIRT005214)

    Block miRNA regulation of human, mouse, rat CTSL using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CTSL
    SwitchGear 3'UTR luciferase reporter plasmidCTSL 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CTSL

    Gene Editing
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    Clone
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    GenScript Custom all cDNA clones Services for CTSL
    Sino Biological Human cDNA Clone for CTSL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSL
    Addgene plasmids for CTSL 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CATL1_HUMAN, P07711: Lysosome

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005634nucleus TAS--
    GO:0005764lysosome IDA15196205
    GO:0036021endolysosome lumen TAS--

    Find genes that share ontologies with CTSL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTSL About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    3CDK-mediated phosphorylation and removal of Cdc6
    Antigen processing-Cross presentation0.80
    Endosomal/Vacuolar pathway0.00
    4Collagen biosynthesis and modifying enzymes
    Collagen formation0.75
    Assembly of collagen fibrils and other multimeric structures0.62
    5Immune response Antigen presentation by MHC class II
    Immune response Antigen presentation by MHC class II0.46


    Find genes that share SuperPaths with CTSL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for CTSL
        Immune response Antigen presentation by MHC class II
    Bacterial infections in CF airways


    Selected Reactome Pathways for CTSL (see all 6)
        Endosomal/Vacuolar pathway
    Assembly of collagen fibrils and other multimeric structures
    Trafficking and processing of endosomal TLR
    Degradation of the extracellular matrix
    Collagen degradation


    5 Kegg Pathways  (Kegg details for CTSL):
        Lysosome
    Phagosome
    Antigen processing and presentation
    Proteoglycans in cancer
    Rheumatoid arthritis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTSL
    Interactions:

        Search GeneGlobe Interaction Network for CTSL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTSL (P077111, 2, 3 ENSP000003453444) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEDO755302, 3, ENSP000002633604MINT-8253935 I2D: score=2 STRING: ENSP00000263360
    CRELD2Q6UXH12, 3MINT-8253924 I2D: score=1 
    BAG6P463793I2D: score=1 
    ENSG00000096155P463793I2D: score=1 
    ENSG00000227761P463793I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002250adaptive immune response IEP15196205
    GO:0006508proteolysis IDA--
    GO:0019882antigen processing and presentation TAS15196205
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    Find genes that share ontologies with CTSL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for CTSL (see all 12)     About this table
    CompoundAction CAS #
    CA 074Inhibitor of cathepsin B[134448-10-5]
    CA-074 Meirreversible inhibitor of intracellular cathepsin B[147859-80-1]
    CalpeptinPotent cathepsin L inhibitor[117591-20-5]
    Cathepsin G Inhibitor Ipotent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G[429676-93-7]
    Cathepsin S inhibitorA slow, tight-binding reversible inhibitor of recombinant cathepsin S[1373215-15-6]
    E 64dthiol protease inhibitor1[88321-09-9]
    E-64Irriversible cysteine protease inhibitor[66701-25-5]
    E-64-cinhibits cathepsin B, cathepsin H, and cathepsin L[76684-89-4]
    L 006235Potent, reversible cathepsin K inhibitor[294623-49-7]
    MDL 28170Potent, selective inhibitor of calpain and cathepsin B[88191-84-8]

    Compounds for CTSL available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CalpeptinCalpain and cathepsin L inhibitor[117591-20-5]
    N-Acetyl-L-leucyl-L-leucyl-L-methionalCathepsin inhibitor[136632-32-1]
    E 64dCathepsin inhibitor; interferes with autolysosomal digestion[88321-09-9]
    L 006235Potent cathepsin K inhibitor[294623-49-7]
    SID 26681509Cathepsin L inhibitor[958772-66-2]

    Selected Novoseek inferred chemical compound relationships for CTSL gene (see all 62)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 89.7 188 1898042 (3), 9563472 (3), 9816040 (2), 10993910 (2) (see all 99)
    n-(2,4-dinitrophenyl)ethylenediamine 81.6 3 9163334 (1), 10727410 (1), 20302511 (1)
    scca1 70.3 6 10653592 (1), 12743426 (1), 9817977 (1)
    actinidin 66.8 4 8654398 (3), 10380357 (1)
    ca 074 60 2 10600517 (1)
    leupeptin 58.1 7 20355055 (2), 7487106 (1), 2297706 (1), 7840205 (1) (see all 5)
    serine 55.6 21 1551416 (2), 9006092 (1), 10653592 (1), 17631863 (1) (see all 19)
    kininogen 55.3 9 12492488 (3), 8654398 (2), 1466282 (1), 8467916 (1) (see all 6)
    anthranilate 53.9 2 9163334 (1), 10727410 (1)
    matrigel 52.7 3 15621884 (1), 8521613 (1), 12715895 (1)



    Find genes that share compounds with CTSL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTSL gene (5 alternative transcripts): 
    NM_001257971.1  NM_001257972.1  NM_001257973.1  NM_001912.4  NM_145918.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343150(uc004api.3 uc004aph.3 uc010mqh.3 uc004apl.3 uc004apk.3)
    ENST00000340342 ENST00000375894 ENST00000495822 ENST00000342020 ENST00000482054

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      QuantiTect SYBR Green Assays in human, mouse, rat CTSL
      QuantiFast Probe-based Assays in human, mouse, rat CTSL

    Selected AceView cDNA sequences (see all 688):

    CR601498 AA969937 AL832167 BU839250 CR617897 BU790538 AA149247 CR626403 
    AI709379 CR624025 CR609955 CR603622 CA309460 CD613343 CR618895 CR601495 
    AW340938 AL549406 CR595008 AL702422 H95126 CR607254 AA151347 BU632024 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CTSL (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a ·
    SP1:                                            -     -     -                       -                                                     -                     
    SP2:                                -     -     -     -     -                       -                                                     -                     
    SP3:                                -     -     -     -     -                       -                                                     -                     
    SP4:                                      -     -     -     -                       -                                                     -                     
    SP5:                                -     -     -     -     -     -     -     -     -     -                                               -                     

    ExUns: 9b ^ 10
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CTSL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CTSL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CTSL Expression
    About this image


    CTSL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Kidney (Urinary System)
    CTSL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTSL Protein Expression
        Custom PCR Arrays for CTSL
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CTSL gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctsl5 cathepsin L   --   13 (33.26 cM) 64363214 
    chicken
    (Gallus gallus)
    Aves CTSL26
    Gallus gallus cathepsin L2 (CTSL2), mRNA.
    66(a)
    1 → many
    Z(41267479-41272899)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    58(a)
    1 → many
    2(40926589-40945236)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL879746.12   -- 75(n)    AL879746.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.265552 Danio rerio cathepsin mRNA, partial cds 76.38(n)    AF498292.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cp13 protein catabolism cathepsin L 54(a)
    (best of 4)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea cpl-13 cathepsin-like protease 50(a)
    (best of 2)
      V(16595339-16597937)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G502601 AT5G50260 53.61(n)
    50.16(a)
      835091  NM_124405.2  NP_568722.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g05569001 Os08g0556900 51.18(n)
    47.47(a)
      4346292  NM_001069014.1  NP_001062479.1 


    ENSEMBL Gene Tree for CTSL (if available)
    TreeFam Gene Tree for CTSL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTSL gene
    CTSF2  CTSO2  CTSW2  CTSV2  CTSK2  CTSS2  CTSH2  CTSC2  
    CTSZ2  
    10 SIMAP similar genes for CTSL using alignment to 3 protein entries:     CATL1_HUMAN (see all proteins):
    CTSL1    CTSV    CTSL3P    CTSS    CTSK    DKFZp686B24257
    CTSH    CTSF    CTSO    CTSW

    Find genes that share paralogs with CTSL           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for CTSL (see all 9)
    PGOHUM00000251240 PGOHUM00000251242 PGOHUM00000251245 PGOHUM00000238490 PGOHUM00000238554


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTSL (see all 212)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1129367271,2
    C,F--90339051(+) CTCTCG/ACCCTG 5 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1497717971,2
    C--90339069(+) CTACAA/CCACCT 5 -- us2k10--------
    rs1447022861,2
    C--90339132(+) TCCTGA/GACCTC 5 -- us2k10--------
    rs1906937351,2
    --90339194(+) ACACAA/GTTCCA 5 -- us2k10--------
    rs1395271011,2
    C--90339201(+) TCCAGA/GTATTC 5 -- us2k10--------
    rs1444587021,2
    --90339284(+) CTCCAC/GAGAAG 5 -- us2k10--------
    rs789850721,2
    C,F--90339318(+) CGGCCG/AGGCAC 5 -- us2k11Minor allele frequency- A:0.10EA 120
    rs1466424891,2
    --90339338(+) CACCTG/TTAATT 5 -- us2k10--------
    rs1413313001,2
    --90339455(+) CAGGCA/GTGGTG 5 -- us2k10--------
    rs1424218331,2
    C--90339464(+) TGGTGC/TGCGCC 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for CTSL (90340434 - 90346384 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CTSL: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTSL
    DNA2.0 Custom Variant and Variant Library Synthesis for CTSL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116880    OMIM disorders: --

    8 diseases for CTSL:    
    About MalaCards
    osteoarthritis    metachromatic leukodystrophy    ischemia    oral cancer
    atherosclerosis    rheumatoid arthritis    meningioma    arthritis


    Find genes that share disorders with CTSL           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CTSL gene (see all 61)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 41.7 39 16918298 (2), 19550400 (2), 11869092 (2), 8835762 (2) (see all 27)
    benign meningioma 41.1 1 11270551 (1)
    pulmonary emphysema 36.4 1 2365815 (1)
    tumors 34.2 104 9816040 (5), 9703780 (4), 16261157 (3), 19915865 (3) (see all 46)
    gingival overgrowth 33.5 3 12466121 (1), 15324353 (1)
    carcinoma squamous cell 31 8 12392065 (2), 19959474 (1), 7612192 (1), 12907202 (1) (see all 5)
    oral cancer 23.4 6 12907202 (2), 8985100 (1), 10987253 (1)
    glioblastoma 21.9 12 17094453 (3), 8521613 (3), 17574778 (3), 19137551 (1) (see all 5)
    cancer 21.7 42 16918298 (4), 19958782 (4), 17855659 (2), 15621884 (2) (see all 23)
    primary tumor 20.9 5 9816040 (1), 19550400 (1), 9508185 (1)

    Tumor Gene Database (TGDB): CTSL

    Export disorders for CTSL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTSL gene, integrated from 10 sources (see all 537):
    (articles sorted by number of sources associating them with CTSL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. (PubMed id 2835398)1, 2, 3 Joseph L.J.... Sukhatme V.P. (J. Clin. Invest. 1988)
    2. The crystal structure of human cathepsin L complexed with E-64. (PubMed id 9141479)1, 2, 9 Fujishima A....Sugarawa T. (FEBS Lett. 1997)
    3. Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment. (PubMed id 8896443)1, 2, 9 Coulombe R....Cygler M. (EMBO J. 1996)
    4. Cloning, genomic organization, and chromosomal localization of human cathepsin L. (PubMed id 8419312)1, 3, 9 Chauhan S.S....Troen B.R. (J. Biol. Chem. 1993)
    5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)
    8. Isolation and sequence of a cDNA for human pro-(cathepsin L). (PubMed id 3421948)1, 2 Gal S. and Gottesman M.M. (Biochem. J. 1988)
    9. Amino acid sequences of the human kidney cathepsins H and L. (PubMed id 3342889)1, 2 Ritonja A.... Turk V. (FEBS Lett. 1988)
    10. The major ras induced protein in NIH3T3 cells is cathepsin L. (PubMed id 3550705)1, 2 Joseph L.J.... Sukhatme V.P. (Nucleic Acids Res. 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1514 HGNC: 2537 AceView: CTSL Ensembl:ENSG00000135047 euGenes: HUgn1514
    ECgene: CTSL Kegg: 1514 H-InvDB: CTSL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTSL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTSL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CTSL gene:
    Search GeneIP for patents involving CTSL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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