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Aliases for CTSL Gene

Aliases for CTSL Gene

  • Cathepsin L 2 3 4 5
  • Major Excreted Protein 3 4
  • Cathepsin L1 2 3
  • EC 3.4.22.15 4 61
  • CTSL1 3 4
  • MEP 3 4
  • EC 3.4.22 61
  • CATL 3

External Ids for CTSL Gene

Previous HGNC Symbols for CTSL Gene

  • CTSL1

Previous GeneCards Identifiers for CTSL Gene

  • GC09P081384
  • GC09P082193
  • GC09P083896
  • GC09P085798
  • GC09P087570
  • GC09P089530
  • GC09P090352

Summaries for CTSL Gene

Entrez Gene Summary for CTSL Gene

  • The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for CTSL Gene

CTSL (Cathepsin L) is a Protein Coding gene. Diseases associated with CTSL include Tracheal Cancer and Eccrine Acrospiroma. Among its related pathways are G-protein signaling N-RAS regulation pathway and Immune System. GO annotations related to this gene include histone binding and cysteine-type peptidase activity. An important paralog of this gene is CTSV.

UniProtKB/Swiss-Prot for CTSL Gene

  • Important for the overall degradation of proteins in lysosomes.

Gene Wiki entry for CTSL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSL Gene

Genomics for CTSL Gene

Regulatory Elements for CTSL Gene

Enhancers for CTSL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F087710 1.8 FANTOM5 Ensembl ENCODE 30.7 -11.9 -11910 7.9 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 FOS JUNB KAT8 SREBF1 CTSL LOC649166 NXNL2 DAPK1 GC09P087714 GC09P087601
GH09F087791 1.7 FANTOM5 Ensembl ENCODE 15.8 +67.4 67402 3.0 PKNOX1 YY1 FOS DEK SP5 GTF2B JUNB REST PPARG KAT8 CTSL ENSG00000214888 DAPK1 ELF2P3 CTSL3P
GH09F087684 1.3 FANTOM5 Ensembl ENCODE 18 -40.0 -40014 2.3 CTCF BMI1 EBF1 ZIC2 RAD21 ZNF316 CTBP1 POLR2A SMC3 NFE2 CTSL GC09P087714 GC09P087601
GH09F087795 1.2 FANTOM5 Ensembl ENCODE 15.8 +70.9 70896 1.2 ZNF146 PKNOX1 BHLHE40 GABPA RAD51 PBX2 NR2C2 MGA CTSL ENSG00000214888 DAPK1 ELF2P3 CTSL3P
GH09F087812 1 FANTOM5 Ensembl 17.5 +87.4 87382 1.0 CTCF ZNF654 ARNT DPF2 REST RAD21 RFX5 JUND KLF16 IKZF1 CTSL DAPK1 ELF2P3 CTSL3P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CTSL on UCSC Golden Path with GeneCards custom track

Promoters for CTSL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001307597 981 2201 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 SP3 NFYC

Genomic Location for CTSL Gene

Chromosome:
9
Start:
87,725,519 bp from pter
End:
87,731,469 bp from pter
Size:
5,951 bases
Orientation:
Plus strand

Genomic View for CTSL Gene

Genes around CTSL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSL Gene

Proteins for CTSL Gene

  • Protein details for CTSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07711-CATL1_HUMAN
    Recommended name:
    Cathepsin L1
    Protein Accession:
    P07711
    Secondary Accessions:
    • Q6IAV1
    • Q96QJ0

    Protein attributes for CTSL Gene

    Size:
    333 amino acids
    Molecular mass:
    37564 Da
    Quaternary structure:
    • Dimer of a heavy and a light chain linked by disulfide bonds.

    Three dimensional structures from OCA and Proteopedia for CTSL Gene

neXtProt entry for CTSL Gene

Selected DME Specific Peptides for CTSL Gene

P07711:
  • QNLVDCS
  • VDWREKG
  • QGQCGSC
  • VLVVGYG
  • CGSCWAF
  • CNGGLMD
  • EGQMFRKTG
  • WRRAVWEKN
  • VTPVKNQ
  • EEFRQVMNGFQN
  • ANDTGFVD
  • MNAFGDMT
  • GCNGGLM
  • GDMTSEE
  • ALMKAVA
  • YWLVKNS
  • DSEESYPY
  • GGLMDYAF
  • DTGFVDIP

Post-translational modifications for CTSL Gene

  • Glycosylation at Asn 221
  • Modification sites at PhosphoSitePlus

Domains & Families for CTSL Gene

Gene Families for CTSL Gene

Suggested Antigen Peptide Sequences for CTSL Gene

Graphical View of Domain Structure for InterPro Entry

P07711

UniProtKB/Swiss-Prot:

CATL1_HUMAN :
  • Belongs to the peptidase C1 family.
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSL: view

Function for CTSL Gene

Molecular function for CTSL Gene

GENATLAS Biochemistry:
cathepsin L,lysosomal cysteine proteinase,papain superfamily,ubiquitously expressed,involved in matrix degradation during endochondral ossification
UniProtKB/Swiss-Prot CatalyticActivity:
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
UniProtKB/Swiss-Prot Function:
Important for the overall degradation of proteins in lysosomes.

Enzyme Numbers (IUBMB) for CTSL Gene

Gene Ontology (GO) - Molecular Function for CTSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IPI 22952693
GO:0004197 cysteine-type endopeptidase activity IDA,TAS --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 12504904
GO:0005518 collagen binding IDA 22952693
genes like me logo Genes that share ontologies with CTSL: view
genes like me logo Genes that share phenotypes with CTSL: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTSL Gene

Localization for CTSL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSL Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTSL gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 5
endosome 5
cytoskeleton 2
cytosol 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CTSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS,TAS --
GO:0005615 extracellular space IDA 22952693
GO:0005634 nucleus TAS 21326229
GO:0005764 lysosome IEA,IDA 1837142
GO:0036021 endolysosome lumen TAS --
genes like me logo Genes that share ontologies with CTSL: view

Pathways & Interactions for CTSL Gene

genes like me logo Genes that share pathways with CTSL: view

Gene Ontology (GO) - Biological Process for CTSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002250 adaptive immune response IEP 15196205
GO:0006508 proteolysis IEA,IDA 8811434
GO:0019882 antigen processing and presentation TAS 15196205
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with CTSL: view

No data available for SIGNOR curated interactions for CTSL Gene

Drugs & Compounds for CTSL Gene

(40) Drugs for CTSL Gene - From: DrugBank, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BIPHENYL-4-YL-ACETALDEHYDE Experimental Pharma Target 0
Cysteinesulfonic Acid Experimental Pharma Target 0
E 64d Pharma Cysteine protease inhibitor, Cathepsin inhibitor; interferes with autolysosomal digestion 0
E-64 Pharma Cysteine protease inhibitor,irriversible, Potent and irreversible cysteine protease inhibitor 0
CA 074 Pharma Cathepsin B inhibitor, Selective cathepsin B inhibitor 0

(34) Additional Compounds for CTSL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for CTSL Gene

Compound Action Cas Number
CA 074 Selective cathepsin B inhibitor 134448-10-5
Calpeptin Calpain and cathepsin L inhibitor 117591-20-5
E 64 Potent and irreversible cysteine protease inhibitor 66701-25-5
E 64d Cathepsin inhibitor; interferes with autolysosomal digestion 88321-09-9
L 006235 Potent cathepsin K inhibitor 294623-49-7

(9) ApexBio Compounds for CTSL Gene

Compound Action Cas Number
Calpain Inhibitor I, ALLN Calpain I/II/ B/L inhibitor 110044-82-1
Calpain Inhibitor II, ALLM Calpain inhibitor 136632-32-1
Cathepsin Inhibitor 1 Cathepsin inhibitor 225120-65-0
E 64d Cysteine protease inhibitor 88321-09-9
E-64 Cysteine protease inhibitor,irriversible 66701-25-5
E-64-c Inhibitor of cysteine proteinases 76684-89-4
Odanacatib (MK-0822) Cathepsin K,potent and selective 603139-19-1
Papain Inhibitor Inhibitor of peptidase activity of Papain 70195-20-9
SID 26681509 Human cathepsin L inhibitor,potent and reversible 958772-66-2
genes like me logo Genes that share compounds with CTSL: view

Transcripts for CTSL Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTSL Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - -
SP9: - - - - - -
SP10: - - - - - - - - -
SP11: -
SP12: - - - - - - - - -
SP13: - - - - - - -
SP14: - - - -
SP15: -

ExUns: 9b ^ 10
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CTSL Gene

GeneLoc Exon Structure for
CTSL
ECgene alternative splicing isoforms for
CTSL

Expression for CTSL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTSL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTSL Gene

This gene is overexpressed in Amniocyte (12.9) and Lung (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTSL Gene



NURSA nuclear receptor signaling pathways regulating expression of CTSL Gene:

CTSL
genes like me logo Genes that share expression patterns with CTSL: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CTSL Gene

Orthologs for CTSL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTSL1 34 35
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia CTSL1 34 35
  • 80.68 (n)
dog
(Canis familiaris)
Mammalia CTSL 35
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctsll3 35
  • 66 (a)
OneToMany
BC051665 35
  • 64 (a)
OneToMany
4930486L24Rik 35
  • 62 (a)
OneToMany
Ctsm 35
  • 58 (a)
OneToMany
Cts8 35
  • 56 (a)
OneToMany
Ctsr 35
  • 55 (a)
OneToMany
Cts3 35
  • 54 (a)
OneToMany
Cts6 35
  • 54 (a)
OneToMany
Ctsj 35
  • 53 (a)
OneToMany
Cts7 35
  • 50 (a)
OneToMany
Ctsq 35
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves CTSL2 35
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ctsla 35
  • 65 (a)
ManyToMany
ctsll 35
  • 62 (a)
ManyToMany
si:dkey-239j18.2 35
  • 57 (a)
ManyToMany
si:dkey-239j18.3 35
  • 57 (a)
ManyToMany
si:dkey-269i1.3 35
  • 57 (a)
ManyToMany
si:dkey-269i1.4 35 35
  • 57 (a)
ManyToMany
si:dkey-26g8.4 35
  • 57 (a)
ManyToMany
si:dkey-26g8.5 35
  • 57 (a)
ManyToMany
zgc:174153 35
  • 57 (a)
ManyToMany
zgc:174855 35
  • 57 (a)
ManyToMany
ctslb 35 35 35
  • 55 (a)
ManyToMany
ctsl.1 35
  • 53 (a)
ManyToMany
Dr.26555 34
fruit fly
(Drosophila melanogaster)
Insecta Cp1 36 35
  • 54 (a)
CG4847 36
  • 42 (a)
26-29kD-proteinase 36
  • 37 (a)
CG11459 36
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea cpl-1 36 35
  • 50 (a)
R09F10.1 36
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G50260 34
  • 53.61 (n)
rice
(Oryza sativa)
Liliopsida Os08g0556900 34
  • 51.18 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.12411 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
ManyToMany
CSA.11034 35
  • 50 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
Species where no ortholog for CTSL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CTSL Gene

ENSEMBL:
Gene Tree for CTSL (if available)
TreeFam:
Gene Tree for CTSL (if available)

Paralogs for CTSL Gene

Paralogs for CTSL Gene

(10) SIMAP similar genes for CTSL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTSL: view

Variants for CTSL Gene

Sequence variations from dbSNP and Humsavar for CTSL Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10123692 -- 87,727,561(+) TTGGT(C/G)TAATC intron-variant
rs10566 -- 87,731,117(+) GTGGA(C/T)GGTGA utr-variant-3-prime
rs111258561 -- 87,728,135(+) TGAAC(A/G)CCTTT intron-variant, reference, missense
rs111444788 -- 87,725,209(+) TAAGA(C/T)ACATA upstream-variant-2KB
rs111657890 -- 87,725,709(+) ACTGG(A/G)CTAGA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CTSL Gene

Variant ID Type Subtype PubMed ID
nsv968717 CNV duplication 23825009
esv2759703 CNV loss 17122850

Variation tolerance for CTSL Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTSL Gene

Human Gene Mutation Database (HGMD)
CTSL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTSL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSL Gene

Disorders for CTSL Gene

MalaCards: The human disease database

(31) MalaCards diseases for CTSL Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tracheal cancer
  • ca trachea
eccrine acrospiroma
  • eccrine hidradenoma
vulva basal cell carcinoma
  • basal cell carcinoma of the vulva
fasciolopsiasis
  • infection by fasciolopsis buski
rectosigmoid junction neoplasm
  • neoplasm of rectosigmoid junction
- elite association - COSMIC cancer census association via MalaCards
Search CTSL in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTSL

Tumor Gene Database (TGDB):
CTSL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTSL
genes like me logo Genes that share disorders with CTSL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSL Gene

Publications for CTSL Gene

  1. The crystal structure of human cathepsin L complexed with E-64. (PMID: 9141479) Fujishima A. … Sugarawa T. (FEBS Lett. 1997) 3 4 22 64
  2. Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment. (PMID: 8896443) Coulombe R. … Cygler M. (EMBO J. 1996) 3 4 22 64
  3. Cloning, genomic organization, and chromosomal localization of human cathepsin L. (PMID: 8419312) Chauhan S.S. … Troen B.R. (J. Biol. Chem. 1993) 2 3 22 64
  4. Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. (PMID: 2835398) Joseph L.J. … Sukhatme V.P. (J. Clin. Invest. 1988) 2 3 4 64
  5. Cathepsin L, target in cancer treatment? (PMID: 19958782) Lankelma J.M. … Van Noorden C.J. (Life Sci. 2010) 3 22 64

Products for CTSL Gene

Sources for CTSL Gene

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