Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CTSL Gene

Aliases for CTSL Gene

  • Cathepsin L 2 3 4
  • Major Excreted Protein 3 4
  • EC 3.4.22.15 4 63
  • CTSL1 3 4
  • MEP 3 4
  • Cathepsin L1 2
  • EC 3.4.22 63
  • CATL 3

External Ids for CTSL Gene

Previous HGNC Symbols for CTSL Gene

  • CTSL1

Previous GeneCards Identifiers for CTSL Gene

  • GC09P081384
  • GC09P082193
  • GC09P083896
  • GC09P085798
  • GC09P087570
  • GC09P089530
  • GC09P090352

Summaries for CTSL Gene

Entrez Gene Summary for CTSL Gene

  • The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for CTSL Gene

CTSL (Cathepsin L) is a Protein Coding gene. Diseases associated with CTSL include eccrine acrospiroma and fasciolopsiasis. Among its related pathways are Immune System and Degradation of the extracellular matrix. GO annotations related to this gene include histone binding and cysteine-type peptidase activity. An important paralog of this gene is CTSW.

UniProtKB/Swiss-Prot for CTSL Gene

  • Important for the overall degradation of proteins in lysosomes

Gene Wiki entry for CTSL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSL Gene

Genomics for CTSL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTSL Gene

Chromosome:
9
Start:
87,725,519 bp from pter
End:
87,731,469 bp from pter
Size:
5,951 bases
Orientation:
Plus strand

Genomic View for CTSL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSL Gene

No data available for Regulatory Elements for CTSL Gene

Proteins for CTSL Gene

  • Protein details for CTSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07711-CATL1_HUMAN
    Recommended name:
    Cathepsin L1
    Protein Accession:
    P07711
    Secondary Accessions:
    • Q6IAV1
    • Q96QJ0

    Protein attributes for CTSL Gene

    Size:
    333 amino acids
    Molecular mass:
    37564 Da
    Quaternary structure:
    • Dimer of a heavy and a light chain linked by disulfide bonds

    Three dimensional structures from OCA and Proteopedia for CTSL Gene

neXtProt entry for CTSL Gene

Proteomics data for CTSL Gene at MOPED

Post-translational modifications for CTSL Gene

  • Glycosylation at Asn 221
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSL Gene

Antibody Products

Domains & Families for CTSL Gene

Gene Families for CTSL Gene

Suggested Antigen Peptide Sequences for CTSL Gene

Graphical View of Domain Structure for InterPro Entry

P07711

UniProtKB/Swiss-Prot:

CATL1_HUMAN :
  • Belongs to the peptidase C1 family.
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSL: view

Function for CTSL Gene

Molecular function for CTSL Gene

GENATLAS Biochemistry:
cathepsin L,lysosomal cysteine proteinase,papain superfamily,ubiquitously expressed,involved in matrix degradation during endochondral ossification
UniProtKB/Swiss-Prot CatalyticActivity:
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity
UniProtKB/Swiss-Prot Function:
Important for the overall degradation of proteins in lysosomes

Enzyme Numbers (IUBMB) for CTSL Gene

Gene Ontology (GO) - Molecular Function for CTSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IPI 22952693
GO:0004197 cysteine-type endopeptidase activity IDA 12809493
GO:0005515 protein binding IPI 12504904
GO:0005518 collagen binding IDA 22952693
GO:0008234 cysteine-type peptidase activity IDA 8811434
genes like me logo Genes that share ontologies with CTSL: view
genes like me logo Genes that share phenotypes with CTSL: view

Animal Models for CTSL Gene

MGI Knock Outs for CTSL:

Animal Model Products

miRNA for CTSL Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTSL

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CTSL Gene

Localization for CTSL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSL Gene

Lysosome.

Gene Ontology (GO) - Cellular Components for CTSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 22952693
GO:0005634 nucleus TAS 21326229
GO:0005764 lysosome IDA 1837142
GO:0036021 endolysosome lumen TAS --
genes like me logo Genes that share ontologies with CTSL: view

No data available for Subcellular locations from COMPARTMENTS for CTSL Gene

Pathways & Interactions for CTSL Gene

genes like me logo Genes that share pathways with CTSL: view

Gene Ontology (GO) - Biological Process for CTSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002250 adaptive immune response IEP 15196205
GO:0006508 proteolysis IDA 8811434
GO:0019882 antigen processing and presentation TAS 15196205
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with CTSL: view

No data available for SIGNOR curated interactions for CTSL Gene

Drugs & Compounds for CTSL Gene

(32) Drugs for CTSL Gene - From: NovoSeek, DrugBank, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprotinin Approved, Withdrawn Pharma Inhibitor of bovine pancreatic trypsin 24
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Dexamethasone Approved, Investigational Pharma Agonist 1806
Heparin Approved, Investigational Pharma Antagonist 672,226
hydroxyproline Approved, Experimental Pharma 0

(40) Additional Compounds for CTSL Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Calpeptin
117591-20-5
L 006235
294623-49-7
N-Acetyl-L-leucyl-L-leucyl-L-methional
136632-32-1
SID 26681509
958772-66-2
Actinidin
genes like me logo Genes that share compounds with CTSL: view

Transcripts for CTSL Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTSL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTSL Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - -
SP9: - - - - - -
SP10: - - - - - - - - -
SP11: -
SP12: - - - - - - - - -
SP13: - - - - - - -
SP14: - - - -
SP15: -

ExUns: 9b ^ 10
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CTSL Gene

GeneLoc Exon Structure for
CTSL
ECgene alternative splicing isoforms for
CTSL

Expression for CTSL Gene

mRNA expression in normal human tissues for CTSL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTSL Gene

This gene is overexpressed in Amniocyte (12.9) and Lung (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTSL Gene



genes like me logo Genes that share expression patterns with CTSL: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CTSL Gene

Orthologs for CTSL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTSL1 35
  • 80.68 (n)
  • 74.47 (a)
CTSL1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTSL1 35
  • 99.7 (n)
  • 100 (a)
CTSL1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctsl 16
4930486L24Rik 36
  • 62 (a)
OneToMany
BC051665 36
  • 64 (a)
OneToMany
Cts3 36
  • 54 (a)
OneToMany
Cts6 36
  • 54 (a)
OneToMany
Cts7 36
  • 50 (a)
OneToMany
Cts8 36
  • 56 (a)
OneToMany
Ctsj 36
  • 53 (a)
OneToMany
Ctsll3 36
  • 66 (a)
OneToMany
Ctsm 36
  • 58 (a)
OneToMany
Ctsq 36
  • 50 (a)
OneToMany
Ctsr 36
  • 55 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CTSL 36
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves CTSL2 36
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii Dr.26555 35
ctsl.1 36
  • 53 (a)
ManyToMany
ctsla 36
  • 65 (a)
ManyToMany
ctslb 36
  • 55 (a)
ManyToMany
ctslb 36
  • 57 (a)
ManyToMany
ctslb 36
  • 57 (a)
ManyToMany
ctsll 36
  • 62 (a)
ManyToMany
si:dkey-239j18.2 36
  • 57 (a)
ManyToMany
si:dkey-239j18.3 36
  • 57 (a)
ManyToMany
si:dkey-269i1.3 36
  • 57 (a)
ManyToMany
si:dkey-269i1.4 36
  • 57 (a)
ManyToMany
si:dkey-269i1.4 36
  • 58 (a)
ManyToMany
si:dkey-26g8.4 36
  • 57 (a)
ManyToMany
si:dkey-26g8.5 36
  • 57 (a)
ManyToMany
zgc:174153 36
  • 57 (a)
ManyToMany
zgc:174855 36
  • 57 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta 26-29kD-proteinase 37
  • 37 (a)
CG11459 37
  • 37 (a)
CG4847 37
  • 42 (a)
Cp1 37
  • 54 (a)
Cp1 36
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cpl-1 37
  • 50 (a)
R09F10.1 37
  • 36 (a)
cpl-1 36
  • 49 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G50260 35
  • 53.61 (n)
  • 50.16 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12411 35
rice
(Oryza sativa)
Liliopsida Os08g0556900 35
  • 51.18 (n)
  • 47.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
CSA.11034 36
  • 50 (a)
ManyToMany
Species with no ortholog for CTSL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CTSL Gene

ENSEMBL:
Gene Tree for CTSL (if available)
TreeFam:
Gene Tree for CTSL (if available)

Paralogs for CTSL Gene

Paralogs for CTSL Gene

(10) SIMAP similar genes for CTSL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTSL: view

Variants for CTSL Gene

Sequence variations from dbSNP and Humsavar for CTSL Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs10566 -- 87,731,117(+) GTGGA(C/T)GGTGA utr-variant-3-prime
rs14805 -- 87,731,272(+) TTACC(C/T)CTATT utr-variant-3-prime
rs1801404 -- 87,727,698(+) CAAGT(G/T)GAAGG reference, missense, utr-variant-5-prime
rs2274611 -- 87,727,760(+) TAGTC(C/T)TGGCT intron-variant
rs2296958 -- 87,729,401(+) TGGAG(C/T)CAATT intron-variant

Variation tolerance for CTSL Gene

Residual Variation Intolerance Score: 49.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTSL Gene

HapMap Linkage Disequilibrium report
CTSL
Human Gene Mutation Database (HGMD)
CTSL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CTSL Gene

Disorders for CTSL Gene

MalaCards: The human disease database

(31) MalaCards diseases for CTSL Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
eccrine acrospiroma
  • eccrine hidradenoma of skin
fasciolopsiasis
  • infectious disease by fasciolopsis
vulva basal cell carcinoma
  • basal cell carcinoma of vulva
trachea adenoid cystic carcinoma
  • tracheal adenoid cystic carcinoma
mandibular cancer
  • mandible cancer
- elite association
Search CTSL in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTSL

Tumor Gene Database (TGDB):
CTSL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTSL
genes like me logo Genes that share disorders with CTSL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSL Gene

Publications for CTSL Gene

  1. Cloning, genomic organization, and chromosomal localization of human cathepsin L. (PMID: 8419312) Chauhan S.S. … Troen B.R. (J. Biol. Chem. 1993) 2 23 67
  2. Legumain and cathepsin-L expression in human unstable carotid plaque. (PMID: 19671471) Mattock K.L. … Smith A. (Atherosclerosis 2010) 23 67
  3. Cathepsin L, target in cancer treatment? (PMID: 19958782) Lankelma J.M. … Van Noorden C.J. (Life Sci. 2010) 23 67
  4. Stefin B interacts with histones and cathepsin L in the nucleus. (PMID: 20075068) Ceru S. … Kopitar-Jerala N. (J. Biol. Chem. 2010) 23 67
  5. Plasminogen hydrolysis by cathepsin S and identification of derived peptides as selective substrate for cathepsin V and cathepsin L inhibitor. (PMID: 20302511) Coppini L.P. … Carmona A.K. (Biol. Chem. 2010) 23 67

Products for CTSL Gene

  • Addgene plasmids for CTSL

Sources for CTSL Gene

Back to Top

Content