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Aliases for CTSL Gene

Aliases for CTSL Gene

  • Cathepsin L 2 3 4
  • Major Excreted Protein 3 4
  • Cathepsin L1 2 3
  • EC 3.4.22.15 4 64
  • CTSL1 3 4
  • MEP 3 4
  • EC 3.4.22 64
  • CATL 3

External Ids for CTSL Gene

Previous Symbols for CTSL Gene

  • CTSL1

Summaries for CTSL Gene

Entrez Gene Summary for CTSL Gene

  • The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for CTSL Gene

CTSL (Cathepsin L) is a Protein Coding gene. Diseases associated with CTSL include rheumatoid arthritis and osteoarthritis. Among its related pathways are Proteoglycans in cancer and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include cysteine-type peptidase activity and cysteine-type endopeptidase activity. An important paralog of this gene is CTSW.

UniProtKB/Swiss-Prot for CTSL Gene

  • Important for the overall degradation of proteins in lysosomes

Tocris Summary for CTSL Gene

  • Cathepsins are a group of lysosomal proteases that have a key role in cellular protein turnover. The term cathepsin includes serine proteases (cathepsins A and G), aspartic proteases (cathepsin D and E) as well as the cysteine proteases (cathepsins B, C, F, H, K, L, O, S, W and Z). Most cathepsins are endopeptidases, with the exception of cathepsin C and Z. Cathepsins are synthesized as inactive proenzymes, glycosylated post-translationally, and directed towards the lysosomal compartment by cellular mannose-6-phosphate receptors. Their activity is regulated by several mechanisms including regulation of synthesis, zymogen processing, inhibition by endogenous inhibitors (e.g. stefins and cystatins for cysteine cathepsins) and pH. The main function of cathepsins is protein recycling within the lysosome but they are also known to be involved in a range of other physiological, as well as pathological processes, including maturation of the MHC class II complex, bone remodeling, keratinocyte differentiation, tumor progression and metastasis, rheumatoid arthritis, osteoarthritis and atherosclerosis.

Gene Wiki entry for CTSL Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSL Gene

Genomics for CTSL Gene

Genomic Location for CTSL Gene

Start:
87,725,519 bp from pter
End:
87,731,469 bp from pter
Size:
5,951 bases
Orientation:
Plus strand

Genomic View for CTSL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSL Gene

No data available for Regulatory Elements for CTSL Gene

Proteins for CTSL Gene

  • Protein details for CTSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07711-CATL1_HUMAN
    Recommended name:
    Cathepsin L1
    Protein Accession:
    P07711
    Secondary Accessions:
    • Q6IAV1
    • Q96QJ0

    Protein attributes for CTSL Gene

    Size:
    333 amino acids
    Molecular mass:
    37564 Da
    Quaternary structure:
    • Dimer of a heavy and a light chain linked by disulfide bonds

    Three dimensional structures from OCA and Proteopedia for CTSL Gene

neXtProt entry for CTSL Gene

Proteomics data for CTSL Gene at MOPED

Post-translational modifications for CTSL Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn221

Other Protein References for CTSL Gene

Domains for CTSL Gene

Gene Families for CTSL Gene

HGNC:
  • CTS :Cathepsins

UniProtKB/Swiss-Prot:

CATL1_HUMAN
Family:
  • Belongs to the peptidase C1 family.:
    • P07711
genes like me logo Genes that share domains with CTSL: view

Function for CTSL Gene

Molecular function for CTSL Gene

GENATLAS Biochemistry: cathepsin L,lysosomal cysteine proteinase,papain superfamily,ubiquitously expressed,involved in matrix degradation during endochondral ossification
UniProtKB/Swiss-Prot CatalyticActivity: Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity
UniProtKB/Swiss-Prot Function: Important for the overall degradation of proteins in lysosomes

Enzyme Numbers (IUBMB) for CTSL Gene

Gene Ontology (GO) - Molecular Function for CTSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IPI 22952693
GO:0004197 cysteine-type endopeptidase activity IDA 12809493
GO:0005515 protein binding IPI 12504904
GO:0005518 collagen binding IDA 22952693
GO:0008234 cysteine-type peptidase activity IDA 8811434
genes like me logo Genes that share ontologies with CTSL: view
genes like me logo Genes that share phenotypes with CTSL: view

Animal Models for CTSL Gene

MGI Knock Outs for CTSL:

miRNA for CTSL Gene

miRTarBase miRNAs that target CTSL

No data available for Transcription Factor Targeting and HOMER Transcription for CTSL Gene

Localization for CTSL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSL Gene

Lysosome.

Gene Ontology (GO) - Cellular Components for CTSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 22952693
GO:0005634 nucleus TAS 21326229
GO:0005764 lysosome IDA 15196205
GO:0036021 endolysosome lumen TAS --
genes like me logo Genes that share ontologies with CTSL: view

Pathways for CTSL Gene

genes like me logo Genes that share pathways with CTSL: view

Gene Ontology (GO) - Biological Process for CTSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002250 adaptive immune response IEP 15196205
GO:0006508 proteolysis IDA 21326229
GO:0019882 antigen processing and presentation TAS 15196205
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with CTSL: view

Compounds for CTSL Gene

(12) ApexBio Compounds for CTSL Gene

Compound Action Cas Number
CA 074 Inhibitor of cathepsin B. [134448-10-5]
CA-074 Me irreversible inhibitor of intracellular cathepsin B. [147859-80-1]
Calpeptin Potent cathepsin L inhibitor [117591-20-5]
Cathepsin G Inhibitor I potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G. [429676-93-7]
Cathepsin S inhibitor A slow, tight-binding reversible inhibitor of recombinant cathepsin S. [1373215-15-6]
E 64d thiol protease inhibitor1 [88321-09-9]
E-64 Irriversible cysteine protease inhibitor [66701-25-5]
E-64-c inhibits cathepsin B, cathepsin H, and cathepsin L [76684-89-4]
L 006235 Potent, reversible cathepsin K inhibitor. [294623-49-7]
MDL 28170 Potent, selective inhibitor of calpain and cathepsin B. [88191-84-8]
Odanacatib (MK-0822) inhibitor of cathepsin K. [603139-19-1]
SID 26681509 Potent and reversible human cathepsin L inhibitor. [958772-66-2]

(5) Tocris Compounds for CTSL Gene

Compound Action Cas Number
Calpeptin Calpain and cathepsin L inhibitor [117591-20-5]
E 64d Cathepsin inhibitor; interferes with autolysosomal digestion [88321-09-9]
L 006235 Potent cathepsin K inhibitor [294623-49-7]
N-Acetyl-L-leucyl-L-leucyl-L-methional Cathepsin inhibitor [136632-32-1]
SID 26681509 Cathepsin L inhibitor [958772-66-2]

(62) Novoseek inferred chemical compound relationships for CTSL Gene

Compound -log(P) Hits PubMed IDs
cysteine 89.7 111
n-(2,4-dinitrophenyl)ethylenediamine 81.6 3
scca1 70.3 3
actinidin 66.8 4
ca 074 60 1
genes like me logo Genes that share compounds with CTSL: view

Transcripts for CTSL Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CTSL Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - -
SP9: - - - - - -
SP10: - - - - - - - - -
SP11: -
SP12: - - - - - - - - -
SP13: - - - - - - -
SP14: - - - -
SP15: -

ExUns: 9b ^ 10
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CTSL Gene

GeneLoc Exon Structure for
CTSL
ECgene alternative splicing isoforms for
CTSL

Expression for CTSL Gene

mRNA expression in normal human tissues for CTSL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTSL Gene

genes like me logo Genes that share expressions with CTSL: view

Orthologs for CTSL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTSL1 36
  • 99.7 (n)
  • 100 (a)
CTSL1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTSL1 36
  • 80.68 (n)
  • 74.47 (a)
CTSL1 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTSL 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930486L24Rik 37
  • 62 (a)
OneToMany
BC051665 37
  • 64 (a)
OneToMany
Cts3 37
  • 54 (a)
OneToMany
Cts6 37
  • 54 (a)
OneToMany
Cts7 37
  • 50 (a)
OneToMany
Cts8 37
  • 56 (a)
OneToMany
Ctsj 37
  • 53 (a)
OneToMany
Ctsl 16
Ctsll3 37
  • 66 (a)
OneToMany
Ctsm 37
  • 58 (a)
OneToMany
Ctsq 37
  • 50 (a)
OneToMany
Ctsr 37
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves CTSL2 37
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ctsl.1 37
  • 53 (a)
ManyToMany
ctsla 37
  • 65 (a)
ManyToMany
ctslb 37
  • 55 (a)
ManyToMany
ctslb 37
  • 57 (a)
ManyToMany
ctslb 37
  • 57 (a)
ManyToMany
ctsll 37
  • 62 (a)
ManyToMany
Dr.26555 36
si:dkey-239j18.2 37
  • 57 (a)
ManyToMany
si:dkey-239j18.3 37
  • 57 (a)
ManyToMany
si:dkey-269i1.3 37
  • 57 (a)
ManyToMany
si:dkey-269i1.4 37
  • 57 (a)
ManyToMany
si:dkey-269i1.4 37
  • 58 (a)
ManyToMany
si:dkey-26g8.4 37
  • 57 (a)
ManyToMany
si:dkey-26g8.5 37
  • 57 (a)
ManyToMany
zgc:174153 37
  • 57 (a)
ManyToMany
zgc:174855 37
  • 57 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Cp1 37
  • 49 (a)
OneToMany
Cp1 38
  • 54 (a)
26-29kD-proteinase 38
  • 37 (a)
CG11459 38
  • 37 (a)
CG4847 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea cpl-1 37
  • 49 (a)
OneToMany
R09F10.1 38
  • 36 (a)
cpl-1 38
  • 50 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G50260 36
  • 53.61 (n)
  • 50.16 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12411 36
rice
(Oryza sativa)
Liliopsida Os08g0556900 36
  • 51.18 (n)
  • 47.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
ManyToMany
-- 37
  • 47 (a)
ManyToMany
CSA.11034 37
  • 50 (a)
ManyToMany
Species with no ortholog for CTSL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CTSL Gene

ENSEMBL:
Gene Tree for CTSL (if available)
TreeFam:
Gene Tree for CTSL (if available)

Paralogs for CTSL Gene

Paralogs for CTSL Gene

Selected SIMAP similar genes for CTSL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTSL: view

Variants for CTSL Gene

Sequence variations from dbSNP and Humsavar for CTSL Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs10566 -- 87,731,117(+) GTGGA(C/T)GGTGA utr-variant-3-prime
rs14805 -- 87,731,272(+) TTACC(C/T)CTATT utr-variant-3-prime
rs1801404 -- 87,727,698(+) CAAGT(G/T)GAAGG reference, missense, utr-variant-5-prime
rs2274611 -- 87,727,760(+) TAGTC(C/T)TGGCT intron-variant
rs2296958 -- 87,729,401(+) TGGAG(C/T)CAATT intron-variant

Relevant External Links for CTSL Gene

HapMap Linkage Disequilibrium report
CTSL
Human Gene Mutation Database (HGMD)
CTSL

No data available for Structural Variations from Database of Genomic Variants (DGV) for CTSL Gene

Disorders for CTSL Gene

(61) Novoseek inferred disease relationships for CTSL Gene

Disease -log(P) Hits PubMed IDs
metastasis 41.7 31
benign meningioma 41.1 1
pulmonary emphysema 36.4 1
tumors 34.2 74
gingival overgrowth 33.5 2

Relevant External Links for CTSL

Tumor Gene Database (TGDB):
CTSL
genes like me logo Genes that share disorders with CTSL: view

No data available for UniProtKB/Swiss-Prot for CTSL Gene

Publications for CTSL Gene

  1. Cloning, genomic organization, and chromosomal localization of human cathepsin L. (PMID: 8419312) Chauhan S.S. … Troen B.R. (J. Biol. Chem. 1993) 2 3 23
  2. Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment. (PMID: 8896443) Coulombe R. … Cygler M. (EMBO J. 1996) 3 4 23
  3. The crystal structure of human cathepsin L complexed with E-64. (PMID: 9141479) Fujishima A. … Sugarawa T. (FEBS Lett. 1997) 3 4 23
  4. Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts. (PMID: 2835398) Joseph L.J. … Sukhatme V.P. (J. Clin. Invest. 1988) 2 3 4
  5. Amino acid sequences of the human kidney cathepsins H and L. (PMID: 3342889) Ritonja A. … Turk V. (FEBS Lett. 1988) 3 4

Products for CTSL Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CTSL
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CTSL
    • Block miRNA regulation of CTSL using miScript Target Protectors
    • Addgene plasmids for CTSL

    Sources for CTSL Gene

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