Aliases for CTSH Gene
External Ids for CTSH Gene
Previous HGNC Symbols for CTSH Gene
Previous GeneCards Identifiers for CTSH Gene
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
GeneCards Summary for CTSH Gene
CTSH (Cathepsin H) is a Protein Coding gene. Diseases associated with CTSH include Thyroid Crisis and Intermittent Explosive Disorder. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protein complex binding and peptidase activity. An important paralog of this gene is CTSK.
UniProtKB/Swiss-Prot for CTSH Gene
Important for the overall degradation of proteins in lysosomes.