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Aliases for CTSH Gene

Aliases for CTSH Gene

  • Cathepsin H 2 3
  • CPSB 3 4
  • N-Benzoylarginine-Beta-Naphthylamide Hydrolase 3
  • Cathepsin B3 3
  • Cathepsin BA 3
  • EC 63
  • Minichain 3
  • EC 3.4.22 63
  • Aleurain 3
  • ACC-4 3
  • ACC-5 3
  • ACC4 3
  • ACC5 3

External Ids for CTSH Gene

Previous HGNC Symbols for CTSH Gene

  • CPSB

Previous GeneCards Identifiers for CTSH Gene

  • GC15P075196
  • GC15M072371
  • GC15M076790
  • GC15M076929
  • GC15M077001
  • GC15M079213
  • GC15M055974

Summaries for CTSH Gene

Entrez Gene Summary for CTSH Gene

  • The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010]

GeneCards Summary for CTSH Gene

CTSH (Cathepsin H) is a Protein Coding gene. Diseases associated with CTSH include thyroid crisis and intermittent explosive disorder. Among its related pathways are Immune System and Transport to the Golgi and subsequent modification. GO annotations related to this gene include protein complex binding and peptidase activity. An important paralog of this gene is CTSW.

UniProtKB/Swiss-Prot for CTSH Gene

  • Important for the overall degradation of proteins in lysosomes

Gene Wiki entry for CTSH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSH Gene

Genomics for CTSH Gene

Regulatory Elements for CTSH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTSH Gene

78,921,058 bp from pter
78,949,574 bp from pter
28,517 bases
Minus strand

Genomic View for CTSH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for CTSH Gene

Proteins for CTSH Gene

  • Protein details for CTSH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pro-cathepsin H
    Protein Accession:
    Secondary Accessions:
    • B2RBK0
    • Q96NY6
    • Q9BUM7

    Protein attributes for CTSH Gene

    335 amino acids
    Molecular mass:
    37394 Da
    Quaternary structure:
    • Composed of a mini chain and a large chain. The large chain may be split into heavy and light chain. All chains are held together by disulfide bonds

    Three dimensional structures from OCA and Proteopedia for CTSH Gene

neXtProt entry for CTSH Gene

Proteomics data for CTSH Gene at MOPED

Post-translational modifications for CTSH Gene

  • Ubiquitination at Lys 106
  • Glycosylation at Asn 101 and Asn 230
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSH Gene

Antibody Products

Domains & Families for CTSH Gene

Gene Families for CTSH Gene

Suggested Antigen Peptide Sequences for CTSH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C1 family.
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSH: view

Function for CTSH Gene

Molecular function for CTSH Gene

GENATLAS Biochemistry:
cathepsin H,lysosomal cysteine proteinase,papain superfamily,ubiquitously expressed,involved in matrix degradation during endochondral ossification
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg- -Xaa bonds) as well as an endopeptidase
UniProtKB/Swiss-Prot Function:
Important for the overall degradation of proteins in lysosomes

Enzyme Numbers (IUBMB) for CTSH Gene

Gene Ontology (GO) - Molecular Function for CTSH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 14766755
GO:0004177 aminopeptidase activity IDA 15127951
GO:0004197 cysteine-type endopeptidase activity TAS 2849458
GO:0004252 serine-type endopeptidase activity ISS --
GO:0005515 protein binding IPI 6203523
genes like me logo Genes that share ontologies with CTSH: view
genes like me logo Genes that share phenotypes with CTSH: view

Animal Model Products

miRNA for CTSH Gene

miRTarBase miRNAs that target CTSH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTSH

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CTSH Gene

Localization for CTSH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSH Gene


Subcellular locations from

Jensen Localization Image for CTSH Gene COMPARTMENTS Subcellular localization image for CTSH gene
Compartment Confidence
cytosol 5
extracellular 5
lysosome 5
vacuole 5
nucleus 2
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CTSH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9050938
GO:0005764 lysosome IDA 1837142
GO:0005829 cytosol IDA 9050938
GO:0070062 extracellular exosome IDA 23376485
GO:0097208 alveolar lamellar body IDA 18216060
genes like me logo Genes that share ontologies with CTSH: view

Pathways & Interactions for CTSH Gene

genes like me logo Genes that share pathways with CTSH: view

Pathways by source for CTSH Gene

Gene Ontology (GO) - Biological Process for CTSH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001656 metanephros development ISS --
GO:0001913 T cell mediated cytotoxicity ISS --
GO:0002250 adaptive immune response IEP 15196205
GO:0002764 immune response-regulating signaling pathway IDA 16822283
GO:0006508 proteolysis TAS 2849458
genes like me logo Genes that share ontologies with CTSH: view

No data available for SIGNOR curated interactions for CTSH Gene

Drugs & Compounds for CTSH Gene

(8) Drugs for CTSH Gene - From: DrugBank, NovoSeek, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane Experimental Pharma Target 0
N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-Succinamide Experimental Pharma Target 0
Para-Toluene Sulfonate Experimental Pharma Target 0
E 64d Pharma Cysteine protease inhibitor, Cathepsin inhibitor; interferes with autolysosomal digestion 0

(1) Additional Compounds for CTSH Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTSH: view

Transcripts for CTSH Gene

Unigene Clusters for CTSH Gene

Cathepsin H:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTSH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTSH Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP6: -

Relevant External Links for CTSH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSH Gene

mRNA expression in normal human tissues for CTSH Gene

mRNA differential expression in normal tissues according to GTEx for CTSH Gene

This gene is overexpressed in Lung (x5.1) and Kidney - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for CTSH Gene

This gene is overexpressed in Nasal epithelium (11.8) and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTSH Gene

SOURCE GeneReport for Unigene cluster for CTSH Gene Hs.148641

genes like me logo Genes that share expression patterns with CTSH: view

Protein tissue co-expression partners for CTSH Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CTSH Gene

Orthologs for CTSH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSH Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTSH 35
  • 86.77 (n)
  • 86.27 (a)
  • 86 (a)
(Canis familiaris)
Mammalia CTSH 35
  • 83.07 (n)
  • 84.95 (a)
  • 88 (a)
(Mus musculus)
Mammalia Ctsh 35
  • 82.88 (n)
  • 83.48 (a)
Ctsh 16
Ctsh 36
  • 83 (a)
(Pan troglodytes)
Mammalia CTSH 35
  • 99.5 (n)
  • 99.7 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ctsh 35
  • 83.38 (n)
  • 83.18 (a)
(Monodelphis domestica)
Mammalia CTSH 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
(Gallus gallus)
Aves CTSH 35
  • 71.75 (n)
  • 73.52 (a)
-- 36
  • 33 (a)
(Anolis carolinensis)
Reptilia CTSH 36
  • 68 (a)
(Danio rerio)
Actinopterygii ctsh 35
  • 67.76 (n)
  • 67.54 (a)
wufc44c02 35
ctsh 36
  • 64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9813 35
fruit fly
(Drosophila melanogaster)
Insecta 26-29kD-proteinase 37
  • 35 (a)
CG4847 37
  • 38 (a)
CG11459 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea R07E3.1 37
  • 31 (a)
R09F10.1 37
  • 35 (a)
Y113G7B.15 37
  • 30 (a)
Y71H2AR.2 36
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G45310 35
  • 54.8 (n)
  • 53.9 (a)
(Glycine max)
eudicotyledons Gma.2302 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7537 35
(Hordeum vulgare)
Liliopsida Hv.1501 35
(Oryza sativa)
Liliopsida Os.7860 35
Os09g0442300 35
  • 56 (n)
  • 50.67 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3543 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.296 36
  • 41 (a)
Species with no ortholog for CTSH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CTSH Gene

Gene Tree for CTSH (if available)
Gene Tree for CTSH (if available)

Paralogs for CTSH Gene

Paralogs for CTSH Gene

(9) SIMAP similar genes for CTSH Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CTSH: view

Variants for CTSH Gene

Sequence variations from dbSNP and Humsavar for CTSH Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs13345 -- 78,932,405(-) TCTGC(A/G)ATCGC synonymous-codon, reference
rs894785 -- 78,922,526(+) AAAGC(G/T)CTCCT intron-variant
rs1036937 -- 78,944,838(+) CCCAG(A/C)GTCCA intron-variant, utr-variant-5-prime
rs1036938 - 78,944,905(+) TCACG(C/G)ACAGT missense, reference, utr-variant-5-prime
rs1036939 -- 78,944,982(+) CACAT(A/C)GCAGC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CTSH Gene

Variant ID Type Subtype PubMed ID
esv33573 CNV Gain+Loss 17666407
nsv1629 CNV Insertion 18451855

Variation tolerance for CTSH Gene

Residual Variation Intolerance Score: 41.99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.12; 87.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTSH Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSH Gene

Disorders for CTSH Gene

MalaCards: The human disease database

(6) MalaCards diseases for CTSH Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
thyroid crisis
  • thyrotoxic crisis
intermittent explosive disorder
  • explosive personality disorder
fibrous meningioma
  • fibroblastic meningioma
  • paroxysmal sleep
neurologic diseases
  • nervous system disorder
- elite association
Search CTSH in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTSH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CTSH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSH Gene

Publications for CTSH Gene

  1. Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a SjAPgren's syndrome-like exocrinopathy. (PMID: 19852957) Schenke-Layland K. … Hamm-Alvarez S.F. (Exp. Eye Res. 2010) 23 67
  2. [Serum activity of chitotriosidase, lysozyme and cathepsin H in patients with lung cancer and patients with inflammatory exudate (preliminary report)]. (PMID: 19388531) GoA8ab K. … Warwas M. (Pol. Merkur. Lekarski 2009) 23 67
  3. Sortilin and prosaposin localize to detergent-resistant membrane microdomains. (PMID: 18992238) Canuel M. … Morales C.R. (Exp. Cell Res. 2009) 23 67
  4. The interactomics of sortilin: an ancient lysosomal receptor evolving new functions. (PMID: 19224451) Canuel M. … Morales C.R. (Histol. Histopathol. 2009) 23 67
  5. Levels of cathepsins S and H in pleural fluids of inflammatory and neoplastic origin. (PMID: 19404922) Bunatova K. … Kos J. (Int. J. Biol. Markers 2009) 23 67

Products for CTSH Gene

Sources for CTSH Gene

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