CTSH Gene

Aliases
for CTSH gene

Previous GC identifers: GC15P075196 GC15M072371 GC15M076790 GC15M076929 GC15M077001 GC15M055974

Summaries
for CTSH gene

Genomic Views
for CTSH gene

RefSeq DNA sequence:

NC_000015.9  NC_018926.1  NT_010194.17  

SwitchGear Promoter luciferase reporter plasmid: CTSH promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSH

CTSH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M079213:  view genomic region     (about GC identifiers)

Proteins
for CTSH gene

1 PDB 3D structure from and Proteopedia for CTSH:

1BZN (3D)    

Explore the universe of human proteins at neXtProt for CTSH: NX_P09668

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CTSH (Cathepsin H)
	Enzo Life Sciences proteins for CTSH
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CTSH
	GenScript Custom Purified and Recombinant Proteins Services for CTSH
	Novus Biologicals CTSH Proteins Novus Biologicals CTSH Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CTSH

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CTSH (Cathepsin H)
	OriGene Antibodies: CTSH OriGene Custom Antibody Services for CTSH
	GenScript Custom Superior Antibodies Services for CTSH
	Novus Biologicals CTSH Antibodies
	Abcam antibodies for CTSH
	Uscn Antibodies for CTSH
	ThermoFisher Antibodies for CTSH

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript CTSH-Activity-based Protease Assay for Compound Screening
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CTSH

Protein Domains /
Families
for CTSH gene

ProtoNet protein and cluster: P09668

Function
for CTSH gene

miRNA Products:		OriGene 3'-UTR Clone: CTSH Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTSH
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CTSH:
		hsa-miR-138
		SwitchGear 3'UTR luciferase reporter plasmid: CTSH 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTSH (see all 7) OriGene shRNA RFP: CTSH OriGene siRNA: CTSH
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSH

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CTSH

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTSH (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTSH (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CTSH (NM_004390)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSH
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSH

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CTSH
		Search LifeMap BioReagents cell lines for CTSH

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CTSH

Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

(inferred from 1 allele) (MGI details for Ctsh)

Pathways & Interactions
for CTSH gene

	Super-pathway	contained gene-specific pathways
1	Immune System	Immune System 1.00 Adaptive Immune System 0.59
2	Lysosome	Lysosome 1.00
3	MHC class II antigen presentation	MHC class II antigen presentation 1.00

3        Reactome Pathways for CTSH

	Adaptive Immune System
	Immune System
	MHC class II antigen presentation

1         Kegg Pathway  (Kegg details for CTSH)

Lysosome

Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

Drugs & Compounds
for CTSH gene

Transcripts
for CTSH gene

Expression
for CTSH gene

CTSH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Stem Cell Differentiation: 5 LifeMap Cells
	Name			Category
	PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)			Heart, Myocardium, Smooth Muscle
	PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
	PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
	Extraembryonic endoderm-like cells (Generation of extrae...)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTSH Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTSH
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSH
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSH

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CTSH

Orthologs
for CTSH gene

Paralogs
for CTSH gene

Paralogs for CTSH gene

TINAG²  CTSL1²  CTSF²  CTSO²  CTSW²  CTSK²  CTSB²  CTSS²  

CTSL2²  CTSC²  TINAGL1²  CTSZ²  

9 SIMAP similar genes for CTSH using alignment to 5 protein entries:     CATH_HUMAN (see all proteins):

DKFZp686B24257    CTSL    CTSL2    CTSK    CTSL1    CTSF

CTSS    CTSO    CTSW

CTSH for paralogs           About GeneDecksing

Genomic Variants
for CTSH gene

10/624 NCBI SNPs in CTSH are shown (see all 624)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs797082851,2		--	55973523(+)	CAGGAA/GGCAGC	1	--	ds5001		0	--	--	--	--
rs749833381,2	C,	--	55973543(+)	ATGGCC/TGCCCT	1	--	ds5001		2		NA	122
rs49870571,2	C,F,H,	--	55974067(-)	CTTTTC/TTGTAT	1	--	ut31		9		MN NS WA	1052
rs10501861,2	C,H	--	55974072(-)	ACTGTC/TTTTTY	1	--	ut31		8		MN NS NA	714
rs58491,2	C,F,H,	--	55974105(+)	AGTAGC/TCCTTC	1	--	ut31 ese3		31		MN NS EA NA CSA WA	3364
rs31291,2	C,F,A,H,	--	55974128(+)	ATATTC/G/TGTGGT	2	--	ut31 ese3		31		MN NA NS EA WA CSA	3129
rs31904571,2	F	--	55974156(-)	TCCTTC/TTTAAC	1	--	ut31		1		MN	184
rs49870561,2	C,F,	--	55974190(-)	ATGACG/ACAAAG	1	--	ut31		5		MN	408
rs31281,2	C,F,H,	--	55974305(+)	ACTTCC/TTCCAG	1	--	ut31 ese3		19		MN NS EA NA	1566
rs2000861041,2	C	--	55974353(+)	CTCCTC/TCTCCG	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for CTSH (79213400 - 79241916 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CTSH
     2 CNVs: 87758 7073
     1 Indel: 77014

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTSH

DNA2.0 Custom Variant and Variant Library Synthesis for CTSH

Disorders / Diseases
for CTSH gene

20/42 diseases for CTSH

10/11 Novoseek disease relationships for CTSH gene (see all 11)    About this table

Publications
for CTSH gene

PubMed articles for CTSH gene, integrated from 9 sources (see all 167): (articles sorted by number of sources associating them with CTSH)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H. (PubMed id 2849458)^{1, 2, 3} Fuchs R.... Gassen H.G. (1988)
2. Analysis of a truncated form of cathepsin H in human prostate tumor cells. (PubMed id 11796715)^{1, 2, 9} Waghray A.... Chen Y.Q. (2002)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Nucleotide sequence of human preprocathepsin H, a lysosomal cysteine proteinase. (PubMed id 2587265)^{1, 2} Fuchs R. and Gassen H.G. (1989)
5. Amino acid sequences of the human kidney cathepsins H and L. (PubMed id 3342889)^{1, 2} Ritonja A.... Turk V. (1988)
6. Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis. (PubMed id 17500053)^{1, 9} Lu J....Cardoso W.V. (2007)
7. Crystal structure of Stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidases. (PubMed id 12581647)^{1, 9} Jenko S....Turk D. (2003)
8. Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis. (PubMed id 18216060)^{1, 9} Woischnik M....Griese M. (2008)
9. Enzymatically modified LDL induces cathepsin H in human monocytes: potential relevance in early atherogenesis. (PubMed id 12615673)^{1, 9} Han S.R....Husmann M. (2003)
10. Enzyme-linked immunosorbent assay for the detection of total cathepsin H in human tissue cytosols and sera. (PubMed id 9050938)^{1, 9} Schweiger A....Kos J. (1997)

External Searches for CTSH gene

Genome Databases showing CTSH gene

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Specialized Databases showing CTSH gene

Products
for CTSH gene