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Aliases for CTSH Gene

Aliases for CTSH Gene

  • Cathepsin H 2 3
  • CPSB 3 4
  • N-Benzoylarginine-Beta-Naphthylamide Hydrolase 3
  • Pro-Cathepsin H 3
  • Cathepsin B3 3
  • Cathepsin BA 3
  • EC 63
  • Minichain 3
  • EC 3.4.22 63
  • Aleurain 3
  • ACC-4 3
  • ACC-5 3
  • ACC4 3
  • ACC5 3

External Ids for CTSH Gene

Previous HGNC Symbols for CTSH Gene

  • CPSB

Previous GeneCards Identifiers for CTSH Gene

  • GC15P075196
  • GC15M072371
  • GC15M076790
  • GC15M076929
  • GC15M077001
  • GC15M079213
  • GC15M055974

Summaries for CTSH Gene

Entrez Gene Summary for CTSH Gene

  • The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010]

GeneCards Summary for CTSH Gene

CTSH (Cathepsin H) is a Protein Coding gene. Diseases associated with CTSH include thyroid crisis and narcolepsy. Among its related pathways are Class I MHC mediated antigen processing and presentation and Lysosome. GO annotations related to this gene include serine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is CTSW.

UniProtKB/Swiss-Prot for CTSH Gene

  • Important for the overall degradation of proteins in lysosomes

Gene Wiki entry for CTSH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSH Gene

Genomics for CTSH Gene

Regulatory Elements for CTSH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTSH Gene

78,921,058 bp from pter
78,949,574 bp from pter
28,517 bases
Minus strand

Genomic View for CTSH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTSH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSH Gene

Proteins for CTSH Gene

  • Protein details for CTSH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pro-cathepsin H
    Protein Accession:
    Secondary Accessions:
    • B2RBK0
    • Q96NY6
    • Q9BUM7

    Protein attributes for CTSH Gene

    335 amino acids
    Molecular mass:
    37394 Da
    Quaternary structure:
    • Composed of a mini chain and a large chain. The large chain may be split into heavy and light chain. All chains are held together by disulfide bonds

    Three dimensional structures from OCA and Proteopedia for CTSH Gene

neXtProt entry for CTSH Gene

Proteomics data for CTSH Gene at MOPED

Post-translational modifications for CTSH Gene

  • Ubiquitination at Lys106
  • Glycosylation at Asn101 and Asn230
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSH Gene

Antibody Products

Domains for CTSH Gene

Gene Families for CTSH Gene

Suggested Antigen Peptide Sequences for CTSH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C1 family.
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSH: view

Function for CTSH Gene

Molecular function for CTSH Gene

GENATLAS Biochemistry:
cathepsin H,lysosomal cysteine proteinase,papain superfamily,ubiquitously expressed,involved in matrix degradation during endochondral ossification
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg- -Xaa bonds) as well as an endopeptidase
UniProtKB/Swiss-Prot Function:
Important for the overall degradation of proteins in lysosomes

Enzyme Numbers (IUBMB) for CTSH Gene

Gene Ontology (GO) - Molecular Function for CTSH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 14766755
GO:0004177 aminopeptidase activity IDA 15127951
GO:0004197 cysteine-type endopeptidase activity TAS 2849458
GO:0004252 serine-type endopeptidase activity ISS --
GO:0005515 protein binding IPI 15127951
genes like me logo Genes that share ontologies with CTSH: view
genes like me logo Genes that share phenotypes with CTSH: view

Animal Model Products

miRNA for CTSH Gene

miRTarBase miRNAs that target CTSH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTSH

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CTSH Gene

Localization for CTSH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSH Gene


Subcellular locations from

Jensen Localization Image for CTSH Gene COMPARTMENTS Subcellular localization image for CTSH gene
Compartment Confidence
cytosol 5
extracellular 5
lysosome 5
vacuole 5
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTSH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001520 outer dense fiber IEA --
GO:0001669 acrosomal vesicle IEA --
GO:0005615 extracellular space IDA 16502470
GO:0005764 lysosome IDA 15196205
GO:0005829 cytosol IDA 9050938
genes like me logo Genes that share ontologies with CTSH: view

Pathways for CTSH Gene

genes like me logo Genes that share pathways with CTSH: view

Pathways by source for CTSH Gene

2 Reactome pathways for CTSH Gene
1 KEGG pathway for CTSH Gene

Gene Ontology (GO) - Biological Process for CTSH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001656 metanephros development ISS --
GO:0001913 T cell mediated cytotoxicity ISS --
GO:0002250 adaptive immune response IEP 15196205
GO:0002764 immune response-regulating signaling pathway IDA 16822283
GO:0006508 proteolysis TAS 2849458
genes like me logo Genes that share ontologies with CTSH: view

Drugs for CTSH Gene

(4) Drugbank Compounds for CTSH Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
5289332 Target experimental
5288147 Target experimental
5287869 Target experimental
Para-Toluene Sulfonate
6101 Target experimental

(1) ApexBio Compounds for CTSH Gene

Compound Action Cas Number
E 64d Cysteine protease inhibitor [88321-09-9]

(4) Novoseek inferred chemical compound relationships for CTSH Gene

Compound -log(P) Hits PubMed IDs
cysteine 77.8 19
actinidin 69.7 2
serine 12.5 1
methionine 0 2
genes like me logo Genes that share compounds with CTSH: view

Compound Products

Transcripts for CTSH Gene

Unigene Clusters for CTSH Gene

Cathepsin H:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTSH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTSH Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP6: -

Relevant External Links for CTSH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSH Gene

mRNA expression in normal human tissues for CTSH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSH Gene

This gene is overexpressed in Lung (5.1) and Kidney - Cortex (4.5).

Protein differential expression in normal tissues for CTSH Gene

This gene is overexpressed in Nasal epithelium (11.8) and Lymph node (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTSH Gene

SOURCE GeneReport for Unigene cluster for CTSH Gene Hs.148641

genes like me logo Genes that share expressions with CTSH: view

Expression partners for CTSH Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CTSH Gene

Orthologs for CTSH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSH Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTSH 35
  • 86.77 (n)
  • 86.27 (a)
  • 86 (a)
(Canis familiaris)
Mammalia CTSH 35
  • 83.07 (n)
  • 84.95 (a)
  • 88 (a)
(Mus musculus)
Mammalia Ctsh 35
  • 82.88 (n)
  • 83.48 (a)
Ctsh 16
Ctsh 36
  • 83 (a)
(Pan troglodytes)
Mammalia CTSH 35
  • 99.5 (n)
  • 99.7 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ctsh 35
  • 83.38 (n)
  • 83.18 (a)
(Monodelphis domestica)
Mammalia CTSH 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
(Gallus gallus)
Aves CTSH 35
  • 71.75 (n)
  • 73.52 (a)
-- 36
  • 33 (a)
(Anolis carolinensis)
Reptilia CTSH 36
  • 68 (a)
(Danio rerio)
Actinopterygii ctsh 35
  • 67.76 (n)
  • 67.54 (a)
wufc44c02 35
ctsh 36
  • 64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9813 35
fruit fly
(Drosophila melanogaster)
Insecta 26-29kD-proteinase 37
  • 35 (a)
CG4847 37
  • 38 (a)
CG11459 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea R07E3.1 37
  • 31 (a)
R09F10.1 37
  • 35 (a)
Y113G7B.15 37
  • 30 (a)
Y71H2AR.2 36
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G45310 35
  • 54.8 (n)
  • 53.9 (a)
(Glycine max)
eudicotyledons Gma.2302 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7537 35
(Hordeum vulgare)
Liliopsida Hv.1501 35
(Oryza sativa)
Liliopsida Os.7860 35
Os09g0442300 35
  • 56 (n)
  • 50.67 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3543 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.296 36
  • 41 (a)
Species with no ortholog for CTSH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CTSH Gene

Gene Tree for CTSH (if available)
Gene Tree for CTSH (if available)

Paralogs for CTSH Gene

Paralogs for CTSH Gene

(9) SIMAP similar genes for CTSH Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CTSH: view

Variants for CTSH Gene

Sequence variations from dbSNP and Humsavar for CTSH Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3128 -- 78,922,050(+) ACTTC(C/T)TCCAG utr-variant-3-prime
rs3129 -- 78,921,873(+) ATATT(C/G/T)GTGGT utr-variant-3-prime
rs5849 -- 78,921,850(+) AGTAG(C/T)CCTTC utr-variant-3-prime
rs10941 -- 78,922,095(-) AGAAG(G/T)AGAGG utr-variant-3-prime
rs12549 -- 78,922,087(-) AGGAA(C/G/T)GGGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CTSH Gene

Variant ID Type Subtype PubMed ID
esv33573 CNV Gain+Loss 17666407
nsv1629 CNV Insertion 18451855

Relevant External Links for CTSH Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSH Gene

Disorders for CTSH Gene

(1) University of Copenhagen DISEASES for CTSH Gene

(11) Novoseek inferred disease relationships for CTSH Gene

Disease -log(P) Hits PubMed IDs
lung tumor 11.3 2
inflammation 7.02 1
glioblastoma 5.41 1
breast cancer 0 1
arthritis 0 1

Relevant External Links for CTSH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CTSH: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CTSH Gene

Publications for CTSH Gene

  1. Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H. (PMID: 2849458) Fuchs R. … Gassen H.G. (Biol. Chem. Hoppe-Seyler 1988) 2 3 4
  2. Analysis of a truncated form of cathepsin H in human prostate tumor cells. (PMID: 11796715) Waghray A. … Chen Y.Q. (J. Biol. Chem. 2002) 3 4 23
  3. Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. (PMID: 20203524) Pierce B.L. … Ahsan H. (Hum. Hered. 2010) 3 48
  4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 48
  5. Serum cathepsin H as a potential prognostic marker in patients with colorectal cancer. (PMID: 15646835) Schweiger A. … Kos J. (Int. J. Biol. Markers 2004) 3 23

Products for CTSH Gene

Sources for CTSH Gene

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