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CTSG Gene

protein-coding   GIFtS: 67
GCID: GC14M025042

Cathepsin G

  See CTSG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cathepsin G1 2
CG2 3
CATG2
EC 3.4.21.203
EC 3.4.218

External Ids:    HGNC: 25321   Entrez Gene: 15112   Ensembl: ENSG000001004487   OMIM: 1168305   UniProtKB: P083113   

Export aliases for CTSG gene to outside databases

Previous GC identifers: GC14M022415 GC14M018830 GC14M023032 GC14M024112 GC14M005157


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTSG Gene:
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of
neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin
C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at
sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CTSG Gene:
CTSG (cathepsin G) is a protein-coding gene. Diseases associated with CTSG include amelanotic melanoma, and acute febrile neutrophilic dermatosis. GO annotations related to this gene include peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is GZMH.

UniProtKB/Swiss-Prot: CATG_HUMAN, P08311
Function: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has
antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by
LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride

Gene Wiki entry for CTSG (Cathepsin G) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTSG gene promoter:
         AP-2alpha isoform 3   FOXO1a   AP-2alpha isoform 2   AP-2alpha   NF-kappaB   NF-kappaB1   FOXO1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTSG promoter sequence
   Search Chromatin IP Primers for CTSG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTSG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q12

CTSG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSG gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M025042:  view genomic region     (about GC identifiers)

Start:
25,042,724 bp from pter      End:
25,045,466 bp from pter
Size:
2,743 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CATG_HUMAN, P08311 (See protein sequence)
Recommended Name: Cathepsin G precursor  
Size: 255 amino acids; 28837 Da
4 PDB 3D structures from and Proteopedia for CTSG:
1AU8 (3D)        1CGH (3D)        1KYN (3D)        1T32 (3D)    
Secondary accessions: Q6IBJ6 Q9UCA5 Q9UCU6

Explore the universe of human proteins at neXtProt for CTSG: NX_P08311

Explore proteomics data for CTSG at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn71
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CTSG (P08311) (see all 5)
     GDSGGPL  VLTAAHC  VTLGAHN  PHSRPYMA 


    See CTSG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001902.1  
    ENSEMBL proteins: 
     ENSP00000216336  
    Reactome Protein details: P08311

    CTSG Human Recombinant Protein Products:

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    Novus Biologicals CTSG Lysates
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    Cloud-Clone Corp. Proteins for CTSG

     
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    antibodies-online proteins for CTSG (13 products) 

     
    antibodies-online peptides for CTSG

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    CTSG Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    CTS: Cathepsins

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P08311

    ProtoNet protein and cluster: P08311

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: CATG_HUMAN, P08311
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with CTSG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATG_HUMAN, P08311
    Function: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has
    antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by
    LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride
    Catalytic activity: Specificity similar to chymotrypsin C
    Enzyme regulation: Inhibited by soybean trypsin inhibitor, benzamidine, the synthetic peptide R13K,
    Z-Gly-Leu-Phe-CH2Cl, phenylmethylsulfonyl fluoride, 3,4-dichloroisocoumarin, DFP, SBTI and alpha-1-antitrypsin.
    Inhibited by LPS from P.aeruginosa but not by LPS from S.minnesota. Not inhibited by elastinal, CMK, TLCK and
    ETDA
    Biophysicochemical properties: Kinetic parameters: KM=1.15 mM for Z-Lys-SBzl; KM=0.26 mM for
    Suc-Ala-Ala-Pro-Phe-SBzl;

         Genatlas biochemistry entry for CTSG:
    cathepsin G,granule serine protease,25kDa,expressed in promyelocyte/promonocyte,oxygen independent phagocytosis of
    Gram- bacteria

         Enzyme Numbers (IUBMB): EC 3.4.21.201 EC 3.4.212

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IDA8194606
    GO:0008201heparin binding IDA11907569
    GO:0008233peptidase activity IDA11907569
         
    Find genes that share ontologies with CTSG           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ctsg):
     hematopoietic system  immune system  liver/biliary system  mortality/aging  normal 
     tumorigenesis 

    Find genes that share phenotypes with CTSG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CTSG: Ctsgtm1Ley Ctsgtm1.1Roes

       genOway: Develop your customized and physiologically relevant rodent model for CTSG

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    Sino Biological Human cDNA Clone for CTSG
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CATG_HUMAN, P08311: Cell surface
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    lysosome3
    vacuole3
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IEA--
    GO:0030141secretory granule IDA11907569

    Find genes that share ontologies with CTSG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTSG About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.37
    ACE Inhibitor Pathway, Pharmacodynamics0.00
    Renin-angiotensin system0.37
    ACE Inhibitor Pathway0.00
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    3Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Metabolism of Angiotensinogen to Angiotensins0.00
    4RNA Polymerase I Promoter Opening
    Systemic lupus erythematosus0.40
    5Matrix Metalloproteinases
    Activation of Matrix Metalloproteinases0.37


    Find genes that share SuperPaths with CTSG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CTSG
        ACE Inhibitor Pathway


    4 Reactome Pathways for CTSG
        Metabolism of Angiotensinogen to Angiotensins
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Degradation of the extracellular matrix
    Activation of Matrix Metalloproteinases

    2 PharmGKB Pathways for CTSG
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for CTSG):
        Neuroactive ligand-receptor interaction
    Lysosome
    Renin-angiotensin system
    Amoebiasis
    Systemic lupus erythematosus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTSG: 
              Wound Healing in human mouse rat
              Alzheimer's Disease in human mouse rat
              Antibacterial Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CTSG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTSG (P083112, 3 ENSP000002163364) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRP1Q079543, ENSP000002430774I2D: score=3 STRING: ENSP00000243077
    SERPINA1P010093, ENSP000003480684I2D: score=3 STRING: ENSP00000348068
    CXCL12P480613, ENSP000003635484I2D: score=2 STRING: ENSP00000363548
    CXCR4P610733, ENSP000003868844I2D: score=2 STRING: ENSP00000386884
    AGTP010193, ENSP000003556274I2D: score=1 STRING: ENSP00000355627
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002003angiotensin maturation TAS--
    GO:0006508proteolysis IDA11907569
    GO:0006955immune response TAS2569462
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--

    Find genes that share ontologies with CTSG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CTSG
    Selected ApexBio Compounds for CTSG (see all 12)     About this table
    CompoundAction CAS #
    CA 074Inhibitor of cathepsin B[134448-10-5]
    CA-074 Meirreversible inhibitor of intracellular cathepsin B[147859-80-1]
    CalpeptinPotent cathepsin L inhibitor[117591-20-5]
    Cathepsin G Inhibitor Ipotent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G[429676-93-7]
    Cathepsin S inhibitorA slow, tight-binding reversible inhibitor of recombinant cathepsin S[1373215-15-6]
    E 64dthiol protease inhibitor1[88321-09-9]
    E-64Irriversible cysteine protease inhibitor[66701-25-5]
    E-64-cinhibits cathepsin B, cathepsin H, and cathepsin L[76684-89-4]
    L 006235Potent, reversible cathepsin K inhibitor[294623-49-7]
    MDL 28170Potent, selective inhibitor of calpain and cathepsin B[88191-84-8]

    Browse Tocris compounds for CTSG (CATG)

    2 DrugBank Compounds for CTSG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Bis-Napthyl Beta-Ketophosphonic Acid-- --target--17139284 17016423 10592235
    2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid-- --target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for CTSG gene (see all 90)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 86.5 263 8354288 (3), 10888624 (3), 7510795 (3), 9920787 (2) (see all 99)
    scca1 76.7 8 10653592 (1), 12743426 (1), 14630915 (1), 12949073 (1) (see all 5)
    4-nitroanilide 69.5 1 2206460 (1)
    chymostatin 69.1 6 10722050 (1), 17013240 (1), 9536127 (1), 18995931 (1)
    elastatinal 68 3 10722050 (1), 16963625 (1)
    diisopropylfluorophosphate 66 6 1406456 (1), 8354288 (1), 1879926 (1), 1658173 (1)
    fmlp 63.3 16 16112105 (3), 7559504 (2), 7888078 (1), 2306372 (1) (see all 11)
    (4-aminophenyl)mercuric acetate 61.4 1 8314909 (1)
    pmsf 58.8 7 9000539 (2), 9536127 (1), 1937776 (1), 12355450 (1)
    succinyl-ala-ala-pro-phe-p-nitroanilide 57.4 4 8408036 (1)



    Find genes that share compounds with CTSG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTSG gene: 
    NM_001911.2  

    Unigene Cluster for CTSG:

    Cathepsin G
    Hs.421724  [show with all ESTs]
    Unigene Representative Sequence: NM_001911
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552252(uc001wpq.3) ENST00000216336
    miRNA
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    Additional mRNA sequence: 

    BC014460.1 CR456807.1 CR541704.1 M16117.1 

    3 DOTS entries:

    DT.442723  DT.95134480  DT.86850691 

    Selected AceView cDNA sequences (see all 55):

    NM_001911 CR541704 BM719703 AI718752 AW468344 M16117 BC014460 AW467275 
    BI833632 BG762718 BX279549 BU621869 AI272833 AA306697 AW293396 AW236211 
    AA356289 AA355657 AW339582 AW467290 AI401738 AW468608 AI970874 AA993752 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTSG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGGGGAA
    CTSG Expression
    About this image


    CTSG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
             Bone marrow-derived hematopoietic stem cells (family)
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Prostate (Endocrine System)
    CTSG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTSG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.421724
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTSG: 
              Wound Healing in human mouse rat
              Alzheimer's Disease in human mouse rat
              Antibacterial Response in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CTSG gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctsg1 , 5 cathepsin G1, 5 75.51(n)1
    70.2(a)1
      14 (28.19 cM)5
    130351  NM_007800.11  NP_031826.11 
     560998815 


    ENSEMBL Gene Tree for CTSG (if available)
    TreeFam Gene Tree for CTSG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTSG gene
    GZMH2  PRTN32  GZMK2  PRSS572  CFD2  ELANE2  CMA12  AZU12  
    GZMM2  GZMA2  GZMB2  
    Selected SIMAP similar genes for CTSG using alignment to 1 protein entry:     CATG_HUMAN(see all similar genes):
    GZMH    GZMB    CMA1    PRTN3    GZMK    KLK4
    GZMM    DF    ELANE    GZMA    KLK15    CFD
    CTRB1    CTRB2    KLK6    KLK8    KLK14    KLK5

    Find genes that share paralogs with CTSG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTSG (see all 117)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466235771,2
    C--25042256(+) CTGTCC/GCTCAG 1 -- ds50010--------
    rs757724911,2
    F--25042465(+) GTGATT/GAGGTC 1 -- ds50011Minor allele frequency- G:0.06WA 118
    rs2019688931,2
    --25042853(+) GGGGGC/GTCTCC 2 T S mis10--------
    rs617371181,2
    C,F--25042909(+) GGCAGG/AAAACT 2 /F syn17Minor allele frequency- A:0.03NS WA CSA NA EU 6057
    rs1381107771,2
    C,F--25042955(+) ACGACT/CTTCCA 2 /K /R mis11Minor allele frequency- C:0.00NA 4552
    rs1436702601,2
    C,F--25042960(+) TTTCCA/GTAGGA 2 Y syn11Minor allele frequency- G:0.00NA 4552
    rs1472608511,2
    F--25042969(+) GAGACG/AATGCC 2 /I syn11Minor allele frequency- A:0.00NA 4552
    rs1998775201,2
    C--25042978(+) CCGTGG/AGCCAC 2 /A syn11Minor allele frequency- A:0.00EU 1147
    rs2019610411,2
    C--25042985(+) CCACAC/TTGTTA 2 N S mis10--------
    rs1391420971,2
    C--25043014(+) GAATCC/TCCCTG 2 G syn11Minor allele frequency- T:0.00NA 4448

    HapMap Linkage Disequilibrium report for CTSG (25042724 - 25045466 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CTSG:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510631CNV Loss20534489

    Human Gene Mutation Database (HGMD): CTSG
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTSG
    DNA2.0 Custom Variant and Variant Library Synthesis for CTSG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116830    OMIM disorders: --

    12 diseases for CTSG:    
    About MalaCards
    amelanotic melanoma    acute febrile neutrophilic dermatosis    gingivitis    cutaneous mastocytosis
    pulmonary emphysema    cholangitis    keratoconus    bronchiectasis
    chediak-higashi syndrome    primary sclerosing cholangitis    lupus nephritis    peritonitis

    5 diseases from the University of Copenhagen DISEASES database for CTSG:
    Vasculitis     Chediak-Higashi syndrome     Lung disease     Ulcerative colitis
    Cystic fibrosis

    Find genes that share disorders with CTSG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CTSG gene (see all 55)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wegeners granulomatosis 64.2 1 2033050 (1)
    vasculitis 55.8 2 18640073 (1), 8536374 (1)
    inflammation 51.1 31 12707281 (2), 7722846 (1), 10527409 (1), 2356859 (1) (see all 29)
    colitis ulcerative 47 12 8163698 (2), 19528350 (2), 11023039 (1), 9773480 (1) (see all 9)
    lung diseases 35.4 3 19679607 (1), 8352807 (1), 10879957 (1)
    leukemia promyelocytic acute 32.1 3 16019164 (1), 8558945 (1), 12750176 (1)
    inflammatory bowel diseases 31.8 3 11269973 (1), 9831423 (1), 9155585 (1)
    rheumatoid arthritis 31 8 16977463 (2), 8929773 (1), 8841833 (1), 16341903 (1) (see all 6)
    cholangitis primary sclerosing 30.8 2 9831423 (1), 1327593 (1)
    glomerulonephritis 29.6 1 15034162 (1)

    Genetic Association Database (GAD): CTSG
    Human Genome Epidemiology (HuGE) Navigator: CTSG (10 documents)

    Export disorders for CTSG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTSG gene, integrated from 10 sources (see all 599):
    (articles sorted by number of sources associating them with CTSG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and chromosomal localization of the human cathepsin G gene. (PubMed id 2569462)1, 2, 3 Hohn P.A.... Ley T.J. (J. Biol. Chem. 1989)
    2. The 1.8 A crystal structure of human cathepsin G in complex with Suc- Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. (PubMed id 8896442)1, 2, 9 Hof P.... Bode W. (EMBO J. 1996)
    3. Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis. (PubMed id 16444434)1, 4, 9 Sipahi T....Akar N. (Clin. Appl. Thromb. Hemost. 2006)
    4. Characterization of polymorphic structure of cathepsin G gene: role in cardiovascular and cerebrovascular diseases. (PubMed id 11557685)1, 4, 9 Herrmann S.M....Paul M. (Arterioscler. Thromb. Vasc. Biol. 2001)
    5. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    6. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2009)
    9. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. (PubMed id 19056482)1, 4 Yoshida T....Yamada Y. (Genomics 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1511 HGNC: 2532 AceView: CTSG Ensembl:ENSG00000100448 euGenes: HUgn1511
    ECgene: CTSG Kegg: 1511 H-InvDB: CTSG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTSG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTSG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTSG gene:
    Search GeneIP for patents involving CTSG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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