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Aliases for CTSG Gene

Aliases for CTSG Gene

  • Cathepsin G 2 3 5
  • CG 3 4
  • EC 3.4.21.20 4
  • EC 3.4.21 61
  • CATG 3

External Ids for CTSG Gene

Previous GeneCards Identifiers for CTSG Gene

  • GC14M022415
  • GC14M018830
  • GC14M023032
  • GC14M024112
  • GC14M025042
  • GC14M005157

Summaries for CTSG Gene

Entrez Gene Summary for CTSG Gene

  • The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CTSG Gene

CTSG (Cathepsin G) is a Protein Coding gene. Diseases associated with CTSG include Papillon-Lefevre Syndrome and Cutaneous Mastocytosis. Among its related pathways are Defensins and Degradation of the extracellular matrix. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is GZMB.

UniProtKB/Swiss-Prot for CTSG Gene

  • Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.

Gene Wiki entry for CTSG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSG Gene

Genomics for CTSG Gene

Regulatory Elements for CTSG Gene

Enhancers for CTSG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G024672 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.4 -97.9 -97891 2.9 TBP ASH2L RELA FOSL1 POLR2A CBX5 EED RELB ETV6 IKZF2 GZMB GZMH CTSG STXBP6 CMA1 CIDEB LTB4R RIPK3 TINF2 KHNYN
GH14G024995 0.6 FANTOM5 26.8 -419.1 -419139 0.4 MAX HNF4A FOXA1 CMA1 CTSG STXBP6 GZMB PIR50915
GH14G024212 1.2 ENCODE 11.6 +361.6 361573 4.9 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CMA1 CTSG HOMEZ MDP1 CHMP4A RNF31 LTB4R ENSG00000260669
GH14G024692 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7.8 -118.2 -118162 3.5 PKNOX1 ARNT YBX1 BMI1 PLRG1 ETV6 RELB IKZF2 CREM GATAD2B GZMB NYNRIN NFATC4 CTSG CMA1 LTB4R CIDEB TINF2 PIR50915 LOC105370413
GH14G024481 1.2 Ensembl ENCODE 10.2 +94.3 94277 0.9 HDGF PKNOX1 ARID4B DMAP1 ZNF48 SLC30A9 ZNF143 ZNF207 SP5 MXD4 CTSG ENSG00000258744 CMA1 SDR39U1 KHNYN LOC101927045
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CTSG on UCSC Golden Path with GeneCards custom track

Genomic Location for CTSG Gene

Chromosome:
14
Start:
24,573,518 bp from pter
End:
24,576,260 bp from pter
Size:
2,743 bases
Orientation:
Minus strand

Genomic View for CTSG Gene

Genes around CTSG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSG Gene

Proteins for CTSG Gene

  • Protein details for CTSG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08311-CATG_HUMAN
    Recommended name:
    Cathepsin G
    Protein Accession:
    P08311
    Secondary Accessions:
    • Q6IBJ6
    • Q9UCA5
    • Q9UCU6

    Protein attributes for CTSG Gene

    Size:
    255 amino acids
    Molecular mass:
    28837 Da
    Quaternary structure:
    • (Microbial infection) Interacts with M.tuberculosis protein Rv3364c.

    Three dimensional structures from OCA and Proteopedia for CTSG Gene

neXtProt entry for CTSG Gene

Selected DME Specific Peptides for CTSG Gene

P08311:
  • NDIMLLQL
  • VLTAAHC
  • GDSGGPL
  • VTLGAHN
  • PHSRPYMA

Post-translational modifications for CTSG Gene

  • Glycosylation at isoforms=71
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for CTSG Gene

Gene Families for CTSG Gene

Suggested Antigen Peptide Sequences for CTSG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08311

UniProtKB/Swiss-Prot:

CATG_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CTSG: view

Function for CTSG Gene

Molecular function for CTSG Gene

GENATLAS Biochemistry:
cathepsin G,granule serine protease,25kDa,expressed in promyelocyte/promonocyte,oxygen independent phagocytosis of Gram- bacteria
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.15 mM for Z-Lys-SBzl {ECO:0000269 PubMed:8194606}; KM=0.26 mM for Suc-Ala-Ala-Pro-Phe-SBzl {ECO:0000269 PubMed:8194606};
UniProtKB/Swiss-Prot CatalyticActivity:
Specificity similar to chymotrypsin C.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by soybean trypsin inhibitor, benzamidine, the synthetic peptide R13K, Z-Gly-Leu-Phe-CH2Cl, phenylmethylsulfonyl fluoride, 3,4-dichloroisocoumarin, DFP, SBTI and alpha-1-antitrypsin. Inhibited by LPS from P.aeruginosa but not by LPS from S.minnesota. Not inhibited by elastinal, CMK, TLCK and ETDA.
UniProtKB/Swiss-Prot EnzymeRegulation:
(Microbial infection) Serine protease activity is inhibited by the M.tuberculosis protein Rv3364c, which leads to the suppression of downstream caspase-1-dependent apoptosis in macrophages.
UniProtKB/Swiss-Prot Function:
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.

Enzyme Numbers (IUBMB) for CTSG Gene

Gene Ontology (GO) - Molecular Function for CTSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity TAS,IDA --
GO:0005515 protein binding IPI 25416956
GO:0008201 heparin binding IDA 11907569
GO:0008233 peptidase activity IDA 11907569
GO:0008236 serine-type peptidase activity IMP 1937776
genes like me logo Genes that share ontologies with CTSG: view
genes like me logo Genes that share phenotypes with CTSG: view

Animal Models for CTSG Gene

MGI Knock Outs for CTSG:

Animal Model Products

  • Taconic Biosciences Mouse Models for CTSG

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CTSG
  • Applied Biological Materials Clones for CTSG

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CTSG Gene

Localization for CTSG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSG Gene

Cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTSG gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
lysosome 5
cytosol 1

Gene Ontology (GO) - Cellular Components for CTSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 20551380
GO:0005634 nucleus IDA 21630459
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with CTSG: view

Pathways & Interactions for CTSG Gene

genes like me logo Genes that share pathways with CTSG: view

Gene Ontology (GO) - Biological Process for CTSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002003 angiotensin maturation TAS --
GO:0006468 protein phosphorylation IDA 8573071
GO:0006508 proteolysis IDA 1861080
GO:0006955 immune response TAS 2569462
GO:0016485 protein processing IBA --
genes like me logo Genes that share ontologies with CTSG: view

No data available for SIGNOR curated interactions for CTSG Gene

Drugs & Compounds for CTSG Gene

(41) Drugs for CTSG Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid Experimental Pharma Target 0
Bis-Napthyl Beta-Ketophosphonic Acid Experimental Pharma Target 0
Cathepsin G Inhibitor I Pharma Cathepsin G inhibitor 0
1,3-BIS(PHENYLMETHYL)-1,3-DIAZETIDINE-2,4-DIONE Pharma 0
Dermolastin Pharma inhibitor 0

(54) Additional Compounds for CTSG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CTSG Gene

Compound Action Cas Number
Cathepsin G Inhibitor I Cathepsin G inhibitor 429676-93-7
genes like me logo Genes that share compounds with CTSG: view

Drug Products

Transcripts for CTSG Gene

mRNA/cDNA for CTSG Gene

Unigene Clusters for CTSG Gene

Cathepsin G:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CTSG
  • Applied Biological Materials Clones for CTSG

Alternative Splicing Database (ASD) splice patterns (SP) for CTSG Gene

No ASD Table

Relevant External Links for CTSG Gene

GeneLoc Exon Structure for
CTSG
ECgene alternative splicing isoforms for
CTSG

Expression for CTSG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTSG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSG Gene

This gene is overexpressed in Whole Blood (x23.0) and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for CTSG Gene

This gene is overexpressed in Neutrophil (44.5) and Nasal epithelium (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTSG Gene



Protein tissue co-expression partners for CTSG Gene

NURSA nuclear receptor signaling pathways regulating expression of CTSG Gene:

CTSG

SOURCE GeneReport for Unigene cluster for CTSG Gene:

Hs.421724

Evidence on tissue expression from TISSUES for CTSG Gene

  • Blood(4.7)
  • Skin(4.4)
  • Bone marrow(3.7)
  • Spleen(3)
  • Lung(2.6)
  • Lymph node(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with CTSG: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTSG Gene

Orthologs for CTSG Gene

This gene was present in the common ancestor of mammals.

Orthologs for CTSG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTSG 34 35
  • 98.04 (n)
cow
(Bos Taurus)
Mammalia CTSG 34
  • 76.19 (n)
-- 35
  • 66 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ctsg 34 16 35
  • 75.51 (n)
rat
(Rattus norvegicus)
Mammalia Ctsg 34
  • 74.89 (n)
dog
(Canis familiaris)
Mammalia CTSG 35
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 45 (a)
OneToMany
Species where no ortholog for CTSG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CTSG Gene

ENSEMBL:
Gene Tree for CTSG (if available)
TreeFam:
Gene Tree for CTSG (if available)

Paralogs for CTSG Gene

Variants for CTSG Gene

Sequence variations from dbSNP and Humsavar for CTSG Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000333362 -- 24,575,228(+) GGCTG(C/T)GTTCC intron-variant
rs1001851042 -- 24,573,244(+) TGGGG(A/C)CTTTG downstream-variant-500B
rs1002706454 -- 24,576,915(+) GCGTG(C/T)GGCTG upstream-variant-2KB
rs1003238583 -- 24,577,830(+) TATAT(A/G)TACCA upstream-variant-2KB
rs1003921584 -- 24,574,806(+) ATTTA(G/T)ATTGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CTSG Gene

Variant ID Type Subtype PubMed ID
nsv510631 CNV deletion 20534489

Variation tolerance for CTSG Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.67; 45.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTSG Gene

Human Gene Mutation Database (HGMD)
CTSG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTSG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSG Gene

Disorders for CTSG Gene

MalaCards: The human disease database

(19) MalaCards diseases for CTSG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
papillon-lefevre syndrome
  • papillon-lefevre disease
cutaneous mastocytosis
  • cm
suppurative periapical periodontitis
  • apical abscess
vasculitis
  • angiitis
wegener granulomatosis
  • wegener's granulomatosis
- elite association - COSMIC cancer census association via MalaCards
Search CTSG in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTSG

Genetic Association Database (GAD)
CTSG
Human Genome Epidemiology (HuGE) Navigator
CTSG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTSG
genes like me logo Genes that share disorders with CTSG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSG Gene

Publications for CTSG Gene

  1. The 1.8 A crystal structure of human cathepsin G in complex with Suc- Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. (PMID: 8896442) Hof P. … Bode W. (EMBO J. 1996) 3 4 22 64
  2. Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa. (PMID: 1937776) Wasiluk K.R. … Gray B.H. (Infect. Immun. 1991) 3 4 22 64
  3. Genomic organization and chromosomal localization of the human cathepsin G gene. (PMID: 2569462) Hohn P.A. … Ley T.J. (J. Biol. Chem. 1989) 2 3 4 64
  4. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PMID: 20056178) Segat L. … Crovella S. (Vaccine 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for CTSG Gene

  • Addgene plasmids for CTSG

Sources for CTSG Gene

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