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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTSG Gene

protein-coding   GIFtS: 67
GCID: GC14M025042

Cathepsin G

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cathepsin G1 2
CG2 3
CATG2
EC 3.4.21.203
EC 3.4.218

External Ids:    HGNC: 25321   Entrez Gene: 15112   Ensembl: ENSG000001004487   OMIM: 1168305   UniProtKB: P083113   

Export aliases for CTSG gene to outside databases

Previous GC identifers: GC14M022415 GC14M018830 GC14M023032 GC14M024112 GC14M005157


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTSG Gene:
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of
neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin
C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at
sites of inflammation. Transcript variants utilizing alternative polyadenylation signals exist for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CTSG Gene: 
CTSG (cathepsin G) is a protein-coding gene. Diseases associated with CTSG include acute febrile neutrophilic dermatosis, and leech infestation, and among its related super-pathways are ACE Inhibitor Pathway and Metabolism of Angiotensinogen to Angiotensins. GO annotations related to this gene include peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is GZMH.

UniProtKB/Swiss-Prot: CATG_HUMAN, P08311
Function: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has
antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by
LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride

Gene Wiki entry for CTSG (Cathepsin G) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTSG gene promoter:
         AP-2alpha isoform 3   FOXO1a   AP-2alpha isoform 2   AP-2alpha   NF-kappaB   NF-kappaB1   FOXO1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTSG promoter sequence
   Search SABiosciences Chromatin IP Primers for CTSG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q12

CTSG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSG gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M025042:  view genomic region     (about GC identifiers)

Start:
25,042,724 bp from pter      End:
25,045,466 bp from pter
Size:
2,743 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CATG_HUMAN, P08311 (See protein sequence)
Recommended Name: Cathepsin G precursor  
Size: 255 amino acids; 28837 Da
Subcellular location: Cell surface
4 PDB 3D structures from and Proteopedia for CTSG:
1AU8 (3D)        1CGH (3D)        1KYN (3D)        1T32 (3D)    
Secondary accessions: Q6IBJ6 Q9UCA5 Q9UCU6

Explore the universe of human proteins at neXtProt for CTSG: NX_P08311

Explore proteomics data for CTSG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08311

  • 4/5 DME Specific Peptides for CTSG (P08311) (see all 5)
     GDSGGPL  VLTAAHC  VTLGAHN  PHSRPYMA 

    CTSG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CTSG Protein Expression
    REFSEQ proteins: NP_001902.1  
    ENSEMBL proteins: 
     ENSP00000216336  
    Reactome Protein details: P08311
    Human Recombinant Protein Products for CTSG: 
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    OriGene Protein Over-expression Lysate for CTSG
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    Novus Biologicals CTSG Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTSG 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IEA--
    GO:0030141secretory granule IDA11907569

    CTSG for ontologies           About GeneDecksing



    CTSG Antibody Products: 
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    Assay Products for CTSG: 
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    Cloud-Clone Corp. CLIAs for CTSG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands
    CTS: Cathepsins

    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P08311

    ProtoNet protein and cluster: P08311

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: CATG_HUMAN, P08311
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    CTSG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATG_HUMAN, P08311
    Function: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has
    antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by
    LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride
    Catalytic activity: Specificity similar to chymotrypsin C
    Enzyme regulation: Inhibited by soybean trypsin inhibitor, benzamidine, the synthetic peptide R13K,
    Z-Gly-Leu-Phe-CH2Cl, phenylmethylsulfonyl fluoride, 3,4-dichloroisocoumarin, DFP, SBTI and alpha-1-antitrypsin.
    Inhibited by LPS from P.aeruginosa but not by LPS from S.minnesota. Not inhibited by elastinal, CMK, TLCK and
    ETDA
    Biophysicochemical properties: Kinetic parameters: KM=1.15 mM for Z-Lys-SBzl; KM=0.26 mM for
    Suc-Ala-Ala-Pro-Phe-SBzl;

         Genatlas biochemistry entry for CTSG:
    cathepsin G,granule serine protease,25kDa,expressed in promyelocyte/promonocyte,oxygen independent phagocytosis of
    Gram- bacteria

         Enzyme Numbers (IUBMB): EC 3.4.21.201 EC 3.4.212

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IDA8194606
    GO:0008201heparin binding IDA11907569
    GO:0008233peptidase activity IDA11907569
         
    CTSG for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ctsg):
     hematopoietic system  immune system  liver/biliary system  mortality/aging  normal 
     tumorigenesis 

    CTSG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CTSG: Ctsgtm1Ley Ctsgtm1.1Roes

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CTSG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTSG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTSG 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CTSG About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    ACE Inhibitor Pathway0.85
    ACE Inhibitor Pathway, Pharmacodynamics0.85
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics0.85
    2Renin-angiotensin system
    Renin-angiotensin system0.43
    Metabolism of Angiotensinogen to Angiotensins0.43
    3Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.79
    Activation of Matrix Metalloproteinases0.40
    4Collagen biosynthesis and modifying enzymes
    Extracellular matrix organization0.39
    5Insulin Processing
    Peptide hormone metabolism0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CTSG
        Selected targets of C/EBPalpha


    1 BioSystems Pathway for CTSG
        ACE Inhibitor Pathway

    5/7        Reactome Pathways for CTSG (see all 7)
        Metabolism of Angiotensinogen to Angiotensins
    Extracellular matrix organization
    Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    Metabolism of proteins
    Degradation of the extracellular matrix

    2 PharmGKB Pathways for CTSG
        ACE Inhibitor Pathway, Pharmacodynamics
    Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics

    5         Kegg Pathways  (Kegg details for CTSG):
        Neuroactive ligand-receptor interaction
    Lysosome
    Renin-angiotensin system
    Amoebiasis
    Systemic lupus erythematosus


    CTSG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTSG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/79 Interacting proteins for CTSG (P083112, 3 ENSP000002163364) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRP1Q079543, ENSP000002430774I2D: score=3 STRING: ENSP00000243077
    SERPINA1P010093, ENSP000003480684I2D: score=3 STRING: ENSP00000348068
    CXCL12P480613, ENSP000003635484I2D: score=2 STRING: ENSP00000363548
    CXCR4P610733, ENSP000003868844I2D: score=2 STRING: ENSP00000386884
    AGTP010193, ENSP000003556274I2D: score=1 STRING: ENSP00000355627
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002003angiotensin maturation TAS--
    GO:0006508proteolysis IDA11907569
    GO:0006955immune response TAS2569462
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--

    CTSG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CTSG for compounds           About GeneDecksing

    EMD Millipore small molecules for CTSG:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for CTSG

    Browse Tocris compounds for CTSG (CATG)

    2 DrugBank Compounds for CTSG    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Bis-Napthyl Beta-Ketophosphonic Acid-- --target--17139284 17016423 10592235
    2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid-- --target--17139284 17016423

    10/90 Novoseek inferred chemical compound relationships for CTSG gene (see all 90)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 86.5 263 8354288 (3), 10888624 (3), 7510795 (3), 9920787 (2) (see all 99)
    scca1 76.7 8 10653592 (1), 12743426 (1), 14630915 (1), 12949073 (1) (see all 5)
    4-nitroanilide 69.5 1 2206460 (1)
    chymostatin 69.1 6 10722050 (1), 17013240 (1), 9536127 (1), 18995931 (1)
    elastatinal 68 3 10722050 (1), 16963625 (1)
    diisopropylfluorophosphate 66 6 1406456 (1), 8354288 (1), 1879926 (1), 1658173 (1)
    fmlp 63.3 16 16112105 (3), 7559504 (2), 7888078 (1), 2306372 (1) (see all 11)
    (4-aminophenyl)mercuric acetate 61.4 1 8314909 (1)
    pmsf 58.8 7 9000539 (2), 9536127 (1), 1937776 (1), 12355450 (1)
    succinyl-ala-ala-pro-phe-p-nitroanilide 57.4 4 8408036 (1)

    Search CenterWatch for drugs/clinical trials and news about CTSG / CATG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for CTSG gene: 
    NM_001911.2  

    Unigene Cluster for CTSG:

    Cathepsin G
    Hs.421724  [show with all ESTs]
    Unigene Representative Sequence: NM_001911
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552252(uc001wpq.3) ENST00000216336
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    BC014460.1 CR456807.1 CR541704.1 M16117.1 

    3 DOTS entries:

    DT.442723  DT.95134480  DT.86850691 

    24/55 AceView cDNA sequences (see all 55):

    AW468344 NM_001911 M16117 AI718752 BM719703 BC014460 CR541704 AI970874 
    BI833632 AI685998 AW339582 AW236211 AJ706064 AW293396 BG762718 AW468608 
    BU621869 CR456807 AW467290 AA355657 AA993752 AI804051 BX279549 AI401738 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTSG expression in normal human tissues (normalized intensities)      CTSG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGAGGGGAA
    CTSG Expression
    About this image


    CTSG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 12 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Bone marrow-derived hematopoietic stem cells
             Bone Marrow CD105+ Cells   
             bone marrow mononuclear cells   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             bone marrow   
     
     Liver (Hepatobiliary System)
             Fetal Liver CD34+ Cells   
     
     Lung (Respiratory System)
             lung ; macrophages   
     
     Tonsil (Hematopoietic System)
             tonsil ; non-germinal center cells   

    See CTSG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTSG

    SOURCE GeneReport for Unigene cluster: Hs.421724
        SABiosciences Expression via Pathway-Focused PCR Arrays including CTSG: 
              Wound Healing in human mouse rat
              Alzheimer's Disease in human mouse rat
              Antibacterial Response in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CTSG gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctsg1 , 5 cathepsin G1, 5 75.51(n)1
    70.2(a)1
      14 (28.19 cM)5
    130351  NM_007800.11  NP_031826.11 
     560998815 
    chicken
    (Gallus gallus)
    Aves CTSG1 cathepsin G 55.79(n)
    47.21(a)
      426049  XM_423728.2  XP_423728.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    41(a)
    40(a)
    possible ortholog
    possible ortholog
    GL343717.1(249182-253080)
    GL343717.1(208040-216141)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-165b19.86
    si:ch211-165b19.46
    (see all 5)
    si:ch211-165b19.4
    (see all 5)
    37(a)
    37(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    9(33700477-33702236)
    9(33687862-33689964)


    ENSEMBL Gene Tree for CTSG (if available)
    TreeFam Gene Tree for CTSG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTSG gene
    GZMH2  PRTN32  GZMK2  PRSS572  CFD2  ELANE2  CMA12  AZU12  
    GZMM2  GZMA2  GZMB2  
    18/58 SIMAP similar genes for CTSG using alignment to 1 protein entry:     CATG_HUMAN(see all similar genes):
    GZMH    GZMB    CMA1    PRTN3    GZMK    KLK4
    KLK15    DF    ELANE    GZMA    GZMM    CFD
    CTRB1    CTRB2    KLK6    KLK8    KLK14    KLK5

    CTSG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/117 SNPs in CTSG are shown (see all 117)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466235771,2
    C--25042256(+) CTGTCC/GCTCAG 1 -- ds50010--------
    rs757724911,2
    F--25042465(+) GTGATT/GAGGTC 1 -- ds50011Minor allele frequency- G:0.06WA 118
    rs2019688931,2
    --25042853(+) GGGGGC/GTCTCC 2 T S mis10--------
    rs617371181,2
    C,F--25042909(+) GGCAGG/AAAACT 2 /F syn17Minor allele frequency- A:0.03NS WA CSA NA EU 6057
    rs1381107771,2
    C,F--25042955(+) ACGACT/CTTCCA 2 /K /R mis11Minor allele frequency- C:0.00NA 4552
    rs1436702601,2
    C,F--25042960(+) TTTCCA/GTAGGA 2 Y syn11Minor allele frequency- G:0.00NA 4552
    rs1472608511,2
    F--25042969(+) GAGACG/AATGCC 2 /I syn11Minor allele frequency- A:0.00NA 4552
    rs1998775201,2
    C--25042978(+) CCGTGG/AGCCAC 2 /A syn11Minor allele frequency- A:0.00EU 1147
    rs2019610411,2
    C--25042985(+) CCACAC/TTGTTA 2 N S mis10--------
    rs1391420971,2
    C--25043014(+) GAATCC/TCCCTG 2 G syn11Minor allele frequency- T:0.00NA 4448

    HapMap Linkage Disequilibrium report for CTSG (25042724 - 25045466 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CTSG:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510631CNV Loss20534489


    Human Gene Mutation Database (HGMD): CTSG
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CTSG
    DNA2.0 Custom Variant and Variant Library Synthesis for CTSG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 116830    OMIM disorders: --

    20/67 diseases for CTSG (see all 67):    About MalaCards
    acute febrile neutrophilic dermatosis    leech infestation    amelanotic melanoma    cutaneous mastocytosis
    alpha-1-antichymotrypsin deficiency    bronchiectasis    primary sclerosing cholangitis    cholangitis
    keratoconus    hemangioendothelioma    periodontal disease    pulmonary emphysema
    wegener's granulomatosis    sclerosing cholangitis    lupus nephritis    chediak-higashi syndrome
    vasculitis    netherton syndrome    mastocytosis    hypersensitivity reaction type ii disease

    5 diseases from the University of Copenhagen DISEASES database for CTSG:
    Vasculitis     Chediak-Higashi syndrome     Lung disease     Ulcerative colitis
    Cystic fibrosis

    CTSG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/55 Novoseek inferred disease relationships for CTSG gene (see all 55)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wegeners granulomatosis 64.2 1 2033050 (1)
    vasculitis 55.8 2 18640073 (1), 8536374 (1)
    inflammation 51.1 31 12707281 (2), 7722846 (1), 10527409 (1), 2356859 (1) (see all 29)
    colitis ulcerative 47 12 8163698 (2), 19528350 (2), 11023039 (1), 9773480 (1) (see all 9)
    lung diseases 35.4 3 19679607 (1), 8352807 (1), 10879957 (1)
    leukemia promyelocytic acute 32.1 3 16019164 (1), 8558945 (1), 12750176 (1)
    inflammatory bowel diseases 31.8 3 11269973 (1), 9831423 (1), 9155585 (1)
    rheumatoid arthritis 31 8 16977463 (2), 8929773 (1), 8841833 (1), 16341903 (1) (see all 6)
    cholangitis primary sclerosing 30.8 2 9831423 (1), 1327593 (1)
    glomerulonephritis 29.6 1 15034162 (1)

    Genetic Association Database (GAD): CTSG
    Human Genome Epidemiology (HuGE) Navigator: CTSG (10 documents)

    Export disorders for CTSG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTSG gene, integrated from 9 sources (see all 597):
    (articles sorted by number of sources associating them with CTSG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and chromosomal localization of the human cathepsin G gene. (PubMed id 2569462)1, 2, 3 Hohn P.A.... Ley T.J. (1989)
    2. The 1.8 A crystal structure of human cathepsin G in complex with Suc- Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. (PubMed id 8896442)1, 2, 9 Hof P.... Bode W. (1996)
    3. Effect of various genetic polymorphisms on the incide nce and outcome of severe sepsis. (PubMed id 16444434)1, 4, 9 Sipahi T....Akar N. (2006)
    4. Characterization of polymorphic structure of cathepsin G gene: role in cardiovascular and cerebrovascular diseases. (PubMed id 11557685)1, 4, 9 Herrmann S.M....Paul M. (2001)
    5. Polymorphisms in innate immunity genes and patients r esponse to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (2010)
    6. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Association of genetic variants with chronic kidney d isease in individuals with different lipid profiles. (PubMed id 19578796)1, 4 Yoshida T....Yamada Y. (2009)
    9. Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. (PubMed id 19056482)1, 4 Yoshida T....Yamada Y. (2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1511 HGNC: 2532 AceView: CTSG Ensembl:ENSG00000100448 euGenes: HUgn1511
    ECgene: CTSG Kegg: 1511 H-InvDB: CTSG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTSG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTSG Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CTSG gene:
    Search GeneIP for patents involving CTSG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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