Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CTSG Gene

Aliases for CTSG Gene

  • Cathepsin G 2 3
  • CG 3 4
  • EC 3.4.21.20 4
  • EC 3.4.21 64
  • CATG 3

External Ids for CTSG Gene

Summaries for CTSG Gene

Entrez Gene Summary for CTSG Gene

  • The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CTSG Gene

CTSG (Cathepsin G) is a Protein Coding gene. Diseases associated with CTSG include acute febrile neutrophilic dermatosis and amelanotic melanoma. Among its related pathways are Degradation of the extracellular matrix and Lysosome. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is ELANE.

UniProtKB/Swiss-Prot for CTSG Gene

  • Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.

Gene Wiki entry for CTSG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSG Gene

Genomics for CTSG Gene

Genomic Location for CTSG Gene

Start:
24,573,518 bp from pter
End:
24,576,260 bp from pter
Size:
2,743 bases
Orientation:
Minus strand

Genomic View for CTSG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTSG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSG Gene

Proteins for CTSG Gene

  • Protein details for CTSG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08311-CATG_HUMAN
    Recommended name:
    Cathepsin G
    Protein Accession:
    P08311
    Secondary Accessions:
    • Q6IBJ6
    • Q9UCA5
    • Q9UCU6

    Protein attributes for CTSG Gene

    Size:
    255 amino acids
    Molecular mass:
    28837 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTSG Gene

neXtProt entry for CTSG Gene

Proteomics data for CTSG Gene at MOPED

Selected DME Specific Peptides for CTSG Gene

Post-translational modifications for CTSG Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn71

Other Protein References for CTSG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CTSG Gene

Gene Families for CTSG Gene

HGNC:

UniProtKB/Swiss-Prot:

CATG_HUMAN
Domain:
  • Contains 1 peptidase S1 domain.:
    • P08311
Family:
  • Belongs to the peptidase S1 family.:
    • P08311
genes like me logo Genes that share domains with CTSG: view

Function for CTSG Gene

Molecular function for CTSG Gene

GENATLAS Biochemistry: cathepsin G,granule serine protease,25kDa,expressed in promyelocyte/promonocyte,oxygen independent phagocytosis of Gram- bacteria
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=1.15 mM for Z-Lys-SBzl {ECO:0000269 PubMed:8194606}; KM=0.26 mM for Suc-Ala-Ala-Pro-Phe-SBzl {ECO:0000269 PubMed:8194606};
UniProtKB/Swiss-Prot CatalyticActivity: Specificity similar to chymotrypsin C
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by soybean trypsin inhibitor, benzamidine, the synthetic peptide R13K, Z-Gly-Leu-Phe-CH2Cl, phenylmethylsulfonyl fluoride, 3,4-dichloroisocoumarin, DFP, SBTI and alpha-1-antitrypsin. Inhibited by LPS from P.aeruginosa but not by LPS from S.minnesota. Not inhibited by elastinal, CMK, TLCK and ETDA.
UniProtKB/Swiss-Prot Function: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.

Enzyme Numbers (IUBMB) for CTSG Gene

Gene Ontology (GO) - Molecular Function for CTSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IDA 12504904
GO:0005515 protein binding IPI 25416956
GO:0008201 heparin binding IDA 11907569
GO:0008233 peptidase activity IDA 11907569
genes like me logo Genes that share ontologies with CTSG: view
genes like me logo Genes that share phenotypes with CTSG: view

Animal Models for CTSG Gene

MGI Knock Outs for CTSG:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CTSG Gene

Localization for CTSG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSG Gene

Cell surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTSG Gene COMPARTMENTS Subcellular localization image for CTSG gene
Compartment Confidence
plasma membrane 5
extracellular 4
lysosome 3
vacuole 3
nucleus 1

Gene Ontology (GO) - Cellular Components for CTSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 20551380
GO:0005634 nucleus IDA 21630459
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with CTSG: view

Pathways for CTSG Gene

genes like me logo Genes that share pathways with CTSG: view

Gene Ontology (GO) - Biological Process for CTSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002003 angiotensin maturation TAS --
GO:0006468 protein phosphorylation IDA 8573071
GO:0006508 proteolysis IDA 11907569
GO:0006955 immune response TAS 2569462
GO:0016485 protein processing IBA --
genes like me logo Genes that share ontologies with CTSG: view

Compounds for CTSG Gene

(12) ApexBio Compounds for CTSG Gene

Compound Action Cas Number
CA 074 Inhibitor of cathepsin B. [134448-10-5]
CA-074 Me irreversible inhibitor of intracellular cathepsin B. [147859-80-1]
Calpeptin Potent cathepsin L inhibitor [117591-20-5]
Cathepsin G Inhibitor I potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G. [429676-93-7]
Cathepsin S inhibitor A slow, tight-binding reversible inhibitor of recombinant cathepsin S. [1373215-15-6]
E 64d thiol protease inhibitor1 [88321-09-9]
E-64 Irriversible cysteine protease inhibitor [66701-25-5]
E-64-c inhibits cathepsin B, cathepsin H, and cathepsin L [76684-89-4]
L 006235 Potent, reversible cathepsin K inhibitor. [294623-49-7]
MDL 28170 Potent, selective inhibitor of calpain and cathepsin B. [88191-84-8]
Odanacatib (MK-0822) inhibitor of cathepsin K. [603139-19-1]
SID 26681509 Potent and reversible human cathepsin L inhibitor. [958772-66-2]

(90) Novoseek inferred chemical compound relationships for CTSG Gene

Compound -log(P) Hits PubMed IDs
serine 86.5 116
scca1 76.7 5
4-nitroanilide 69.5 1
chymostatin 69.1 4
elastatinal 68 2
genes like me logo Genes that share compounds with CTSG: view

Transcripts for CTSG Gene

mRNA/cDNA for CTSG Gene

Unigene Clusters for CTSG Gene

Cathepsin G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTSG Gene

No ASD Table

Relevant External Links for CTSG Gene

GeneLoc Exon Structure for
CTSG
ECgene alternative splicing isoforms for
CTSG

Expression for CTSG Gene

mRNA expression in normal human tissues for CTSG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSG Gene

This gene is overexpressed in Whole Blood (23.0) and Skin - Sun Exposed (Lower leg) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTSG Gene

SOURCE GeneReport for Unigene cluster for CTSG Gene Hs.421724

genes like me logo Genes that share expressions with CTSG: view

Orthologs for CTSG Gene

This gene was present in the common ancestor of mammals.

Orthologs for CTSG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTSG 36
  • 98.04 (n)
  • 96.86 (a)
CTSG 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 66 (a)
OneToMany
-- 37
  • 62 (a)
OneToMany
CTSG 36
  • 76.19 (n)
  • 67.53 (a)
dog
(Canis familiaris)
Mammalia CTSG 37
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctsg 36
  • 75.51 (n)
  • 70.2 (a)
Ctsg 16
Ctsg 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 52 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 45 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ctsg 36
  • 74.89 (n)
  • 71.37 (a)
Species with no ortholog for CTSG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CTSG Gene

ENSEMBL:
Gene Tree for CTSG (if available)
TreeFam:
Gene Tree for CTSG (if available)

Paralogs for CTSG Gene

Paralogs for CTSG Gene

genes like me logo Genes that share paralogs with CTSG: view

Variants for CTSG Gene

Sequence variations from dbSNP and Humsavar for CTSG Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1885597 -- 24,573,862(+) CTGCT(G/T)CCCTG intron-variant
rs1957523 -- 24,575,506(+) GGGGA(C/T)GGCAG intron-variant
rs2070697 -- 24,574,883(-) TCCCC(A/G)TGCTG intron-variant
rs2236742 -- 24,575,924(-) TTTGT(A/G)TAAAT intron-variant
rs3759639 -- 24,576,538(+) CTCAA(C/T)CCATC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CTSG Gene

Variant ID Type Subtype PubMed ID
nsv510631 CNV Loss 20534489

Relevant External Links for CTSG Gene

HapMap Linkage Disequilibrium report
CTSG
Human Gene Mutation Database (HGMD)
CTSG

Disorders for CTSG Gene

(55) Novoseek inferred disease relationships for CTSG Gene

Disease -log(P) Hits PubMed IDs
wegeners granulomatosis 64.2 1
vasculitis 55.8 2
inflammation 51.1 30
colitis ulcerative 47 11
lung diseases 35.4 3

Relevant External Links for CTSG

Genetic Association Database (GAD)
CTSG
Human Genome Epidemiology (HuGE) Navigator
CTSG
genes like me logo Genes that share disorders with CTSG: view

No data available for UniProtKB/Swiss-Prot for CTSG Gene

Publications for CTSG Gene

  1. The 1.8 A crystal structure of human cathepsin G in complex with Suc- Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificities. (PMID: 8896442) Hof P. … Bode W. (EMBO J. 1996) 3 4 23
  2. Characterization of polymorphic structure of cathepsin G gene: role in cardiovascular and cerebrovascular diseases. (PMID: 11557685) Herrmann S.M. … Paul M. (Arterioscler. Thromb. Vasc. Biol. 2001) 3 23 49
  3. Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis. (PMID: 16444434) Sipahi T. … Akar N. (Clin. Appl. Thromb. Hemost. 2006) 3 23 49
  4. Genomic organization and chromosomal localization of the human cathepsin G gene. (PMID: 2569462) Hohn P.A. … Ley T.J. (J. Biol. Chem. 1989) 2 3 4
  5. Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor. (PMID: 11520773) LAcvesque J.P. … Simmons P.J. (Blood 2001) 3 23

Products for CTSG Gene

Sources for CTSG Gene

Back to Top

Content