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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CTSF Gene

protein-coding GIFtS: 65
GCID: GC11M066332

cathepsin F

Explore 10 diseases affiliated with
CTSF via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cathepsin F¹ ²
CATSF¹ ² ³
CLN13¹ ²
EC 3.4.22.41³ ⁸
EC 3.4.22⁸

External Ids:	HGNC: 2531¹	Entrez Gene: 8722²	Ensembl: ENSG00000174080⁷	OMIM: 603539⁵	UniProtKB: Q9UBX1³

Export aliases for CTSF gene to outside databases

Previous GC identifers: GC11M068865 GC11M068012 GC11M066580 GC11M066106 GC11M066088 GC11M062658

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTSF:

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system.

Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature

region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain

similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain

predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine

proteases in that it contains this additional N-terminal segment predicted to share structural similarities with

cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements

known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19

residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the

endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously

expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CATF_HUMAN, Q9UBX1

Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has

also been implicated in tumor invasion and metastasis

Gene Wiki entry for CTSF (Cathepsin F)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CTSF gene promoter:
GR USF1 Spz1 AP-1 CUTL1 CREB deltaCREB FOXO4 GR-alpha TGIF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CTSF promoter sequence

Search SABiosciences Chromatin IP Primers for CTSF

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13.2

CTSF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSF gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M066332: view genomic region (about GC identifiers)

Start:	66,330,934 bp from pter	End:	66,336,312 bp from pter
Size:	5,379 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CATF_HUMAN, Q9UBX1 (See protein sequence)

Recommended Name: Cathepsin F precursor

Size: 484 amino acids; 53366 Da

Subcellular location: Lysosome

2 PDB 3D structures from and Proteopedia for CTSF:

1D5U (3D)

1M6D (3D)

Secondary accessions: B2R964 O95240 Q9NSU4 Q9UKQ5

Explore the universe of human proteins at neXtProt for CTSF: NX_Q9UBX1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UBX1

2 DME Specific Peptides for CTSF (Q9UBX1)

CGSCWAF

FSDLTEEEF

CTSF Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003784.2

ENSEMBL proteins:

ENSP00000310832 ENSP00000434936 ENSP00000433082 ENSP00000435822

Reactome Protein details: Q9UBX1
Human Recombinant Protein Products:

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	Novus Biologicals CTSF Protein Novus Biologicals CTSF Lysate
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CTSF

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005764	lysosome	TAS	9822672
GO:0043202	lysosomal lumen	TAS	--

CTSF for ontologies About GeneDecksing

CTSF Antibody Products:

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	Uscn ELISAs and CLIAs for CTSF

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CTSF for domains About GeneDecksing

5 InterPro domains/families:

IPR013128 Peptidase_C1A

IPR000169 Pept_cys_AS

IPR013201 Prot_inhib_I29

IPR025660 Pept_his_AS

IPR000668 Peptidase_C1A_C

Graphical View of Domain Structure for InterPro Entry Q9UBX1

ProtoNet protein and cluster: Q9UBX1

2 Blocks protein families:

IPB000668 Papain cysteine protease (C1) family signature

IPB013201 Proteinase inhibitor I29

UniProtKB/Swiss-Prot: CATF_HUMAN, Q9UBX1

Similarity: Belongs to the peptidase C1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CATF_HUMAN, Q9UBX1

Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has

also been implicated in tumor invasion and metastasis

Catalytic activity: The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with

high specificity constant (k(cat)/K(m)) comparable to that of cathepsin L

Genatlas biochemistry entry for CTSF:

cysteine proteinase,papain family,cathepsin F,widely expressed,involved in degradative processes during tumor

progression,subgroup F-like protease

Enzyme Numbers (IUBMB): EC 3.4.22.41¹ ² EC 3.4.22²

miRNA Products:		OriGene 3'-UTR Clone: CTSF Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTSF
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CTSF:
		hsa-miR-3184 hsa-miR-137 hsa-miR-3065-3p hsa-miR-3065-5p hsa-miR-29c hsa-miR-29a hsa-miR-423-5p hsa-miR-29b

		SwitchGear 3'UTR luciferase reporter plasmid: CTSF 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTSF (see all 7) OriGene shRNA RFP: CTSF OriGene siRNA: CTSF
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Gene Editing
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		Search LifeMap BioReagents cell lines for CTSF

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSF

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004197	cysteine-type endopeptidase activity	TAS	9822672
GO:0008234	cysteine-type peptidase activity	--	--

CTSF for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CTSF:

Decreased Hepatitis C virus re

Animal Models:
Mouse knock-out Ctsf^tm1Hap for CTSF
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ctsf):

behavior/neurological

growth/size

mortality/aging

nervous system

CTSF for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Lysosome

Lysosome

1.00

MHC class II antigen presentation

MHC class II antigen presentation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for CTSF

	Adaptive Immune System
	Immune System
	MHC class II antigen presentation

1 Kegg Pathway (Kegg details for CTSF):

Lysosome

CTSF for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CTSF

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/9 Interacting proteins for CTSF (Q9UBX1³ ENSP00000310832⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD74	P04233³, ENSP00000009530⁴	I2D: score=2 STRING: ENSP00000009530
TAF12	Q16514³	I2D: score=2
NCAM2	O15394³	I2D: score=1
CTSS	ENSP00000357981⁴	STRING: ENSP00000357981
HLA-DRB1	ENSP00000353099⁴	STRING: ENSP00000353099

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS	--

CTSF for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CTSF for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CTSF

8 DrugBank Compounds for CTSF About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
4-Morpholin-4-Yl-Piperidine-1-Carboxylic Acid [1-(3-Benzenesulfonyl-1-Propyl-Allylcarbamoyl)-2-Phenylethyl]-Amide	--	--	target	--	17139284 17016423
BENZOYL-TYROSINE-ALANINE-METHYL KETONE	--	--	target	--	10592235
Benzoyl-Arginine-Alanine-Methyl Ketone	--	--	target	--	10592235
HOMOPHENYLALANINYLMETHANE	--	--	target	--	10592235
WRR-112	--	--	target	--	10592235
WRR-99	--	--	target	--	10592235
[1-(1-Benzyl-3-Hydroxy-2-Oxo-Propylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl Ester	--	--	target	--	10592235
[1-(1-Methyl-4,5-Dioxo-Pent-2-Enylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl Ester	--	--	target	--	10592235

2 Novoseek chemical compound relationships for CTSF gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
divinyl sulfone	78.7	2	12225749 (1), 12454497 (1)
cysteine	66.9	13	10318784 (4), 10198209 (3), 10661872 (1), 9822672 (1) (see all 8)

Search CenterWatch for drugs/clinical trials and news about CTSF / CATF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CTSF gene:

NM_003793.3

Unigene Cluster for CTSF:

Cathepsin F

Hs.11590 [show with all ESTs]

Unigene Representative Sequence: BC013359

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000310325(uc001oip.3) ENST00000527141 ENST00000525733 ENST00000524994

ENST00000530565 ENST00000529199 ENST00000529561 ENST00000533168 ENST00000526010

miRNA Products:		OriGene 3'-UTR Clone: CTSF Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTSF
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CTSF:
		hsa-miR-3184 hsa-miR-137 hsa-miR-3065-3p hsa-miR-3065-5p hsa-miR-29c hsa-miR-29a hsa-miR-423-5p hsa-miR-29b

		SwitchGear 3'UTR luciferase reporter plasmid: CTSF 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: CTSF (NM_003793)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSF

Additional cDNA sequence:

AF071748.1 AF071749.1 AF088886.2 AF136279.1 AJ007331.1 AK313657.1 AL137742.1 BC011682.2

BC013359.2 BC036451.1 CR541680.1

6 DOTS entries:

DT.111592 DT.100817827 DT.95281684 DT.92428022 DT.92428023 DT.95099455

24/210 AceView cDNA sequences (see all 210):

BU742891 BU734302 BX451495 AA937142 BE501402 CR541680 BM710498 BI755456

AI028147 AA323194 CB269409 BQ575903 BM712529 BM716355 BM987509 BM723542

BQ005952 AA322096 BU687274 AL137742 BM971582 AA321987 AI081060 BM673807

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CTSF (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13	^	14
SP1:							-
SP2:
SP3:			-				-
SP4:													-
SP5:																															-

ECgene alternative splicing isoforms for CTSF

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CTSF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAGGAAAC

About this image

CTSF expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CTSF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTSF

SOURCE GeneReport for Unigene cluster: Hs.11590

UniProtKB/Swiss-Prot: CATF_HUMAN, Q9UBX1

Tissue specificity: High expression levels in heart, skeletal muscle, brain, testis and ovary; moderate levels in

prostate, placenta, liver and colon; and no detectable expression in peripheral leukocytes and thymus

SABiosciences Custom PCR Arrays for CTSF

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSF

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSF gene from 5/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
zebrafish (Danio rerio)	Actinopterygii	ctsf¹	cathepsin F	56.92(n) 52.9(a)	565588 NM_001077568.1 NP_001071036.1
fruit fly (Drosophila melanogaster)	Insecta	CG12163³	cathepsin F	45(a)	82F7 --
worm (Caenorhabditis elegans)	Secernentea	F41E6.6³ tag-196¹	cysteine protease and a protease inhibitor³ Protein TAG-196¹	45(a) (best of 3)³ 52.35(n)¹ 49.66(a)¹	V(8597514-8599945)³ 179240¹ NM_072814.2¹ NP_505215.2¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G54940¹	Papain family cysteine protease	48.92(n) 47.44(a)	824659 NM_115351.6 NP_567010.5
rice (Oryza sativa)	Liliopsida	Os07g0480900¹	hypothetical protein	53.58(n) 47.44(a)	4343231 NM_001066174.1 NP_001059639.1

ENSEMBL Gene Tree for CTSF (if available)
TreeFam Gene Tree for CTSF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CTSF gene

TINAG² CTSL1² CTSO² CTSW² CTSK² CTSB² CTSL2² CTSS²

CTSH² CTSC² TINAGL1² CTSZ²

9 SIMAP similar genes for CTSF using alignment to 5 protein entries: CATF_HUMAN (see all proteins):

DKFZp686B24257 CTSW CTSH CTSL1 CTSS CTSL2

CTSO CTSL CTSK

CTSF for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144556402^1,2	F	--	66331452(+)	`GCCCCG/AGACCC`	2	/S	syn¹		1		NA	4478
rs572846^1,2	C,F,O,A,H,	--	66331458(-)	`CATCGC/TGGGTC`	2	R	syn¹ ese³		34		EA NA MN NS WA CSA EU	9922
rs149999352^1,2	C,	--	66331519(+)	`TAGGAA/TGGCGG`	1	--	int¹		0	--	--	--	--
rs148155987^1,2	C,F,	--	66331571(+)	`CCCCAG/ATCAGT`	2	/D	syn¹		1		NA	4486
rs73505406^1,2	C,	--	66331636(+)	`CAGAGC/TGCAAG`	1	--	int¹		1		WA	2
rs11227533^1,2	C,F,H,	--	66331666(+)	`CCAGGC/AAGAGC`	1	--	int¹		5		NS EA NA	538
rs111799708^1,2	F,	--	66331712(+)	`GGCCTG/ACTGTG`	1	--	int¹		1		CSA	5
rs17147739^1,2	C,	--	66331722(+)	`GTGACA/CGGGAC`	1	--	int¹		4		NA WA	260
rs183930092^1,2		--	66331749(+)	`AGCGAA/GGGGCC`	1	--	int¹		0	--	--	--	--
rs189448201^1,2		--	66331755(+)	`GGGCCA/CACCTA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CTSF (66330934 - 66336312 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CTSF: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CTSF for disorders           About GeneDecksing

OMIM gene information: 603539    OMIM disorders: --

10 diseases for CTSF:    About MalaCards

clonorchiasis opisthorchiasis keratopathy bipolar disorder

keratoconus cervical cancer cervicitis osteosarcoma

prostate cancer prostatitis

2 diseases from the University of Copenhagen DISEASES database for CTSF:

Clonorchiasis Keratopathy

Human Genome Epidemiology (HuGE) Navigator: CTSF (3 documents)

Export disorders for CTSF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CTSF gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with CTSF)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain. (PubMed id 10318784)^{1, 2, 3, 9} Santamaria I.... Lopez-Otin C. (1999)
Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. (PubMed id 9822672)^{1, 2, 3, 9} Wang B.... Broemme D. (1998)
Human cathepsins F and W: a new subgroup of cathepsins. (PubMed id 10362521)^{1, 2, 9} Wex T.... Bromme D. (1999)
Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen. (PubMed id 10198209)^{1, 2, 9} Naegler D.K.... Menard R. (1999)
The human cathepsin F gene -- a fusion product between an ancestral cathepsin and cystatin gene. (PubMed id 10661872)^{1, 2, 9} Wex T.... Broemme D. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mouse cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene. (PubMed id 10876093)^{1, 9} Deussing J....Peters C. (2000)
Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro. (PubMed id 15184381)^{1, 9} Oorni K....Kovanen P.T. (2004)
Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: an angiotensin II type 2 receptor-mediated effect. (PubMed id 16963053)^{1, 9} Kaakinen R....Oorni K. (2007)
The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators. (PubMed id 12225749)^{2, 9} Somoza J.R.... Ho J.D. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8722	HGNC: 2531	AceView: CTSF	Ensembl:ENSG00000174080	euGenes: HUgn8722
ECgene: CTSF	Kegg: 8722	H-InvDB: CTSF

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CTSF	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CTSF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CTSF gene:
Search GeneIP for patents involving CTSF

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Advanced Cell Diagnostics
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