Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTSF Gene

protein-coding   GIFtS: 68
GCID: GC11M066332

Cathepsin F

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cathepsin F1 2
CATSF2 3
EC 3.4.22.413 8
CLN132
EC 3.4.228

External Ids:    HGNC: 25311   Entrez Gene: 87222   Ensembl: ENSG000001740807   OMIM: 6035395   UniProtKB: Q9UBX13   

Export aliases for CTSF gene to outside databases

Previous GC identifers: GC11M068865 GC11M068012 GC11M066580 GC11M066106 GC11M066088 GC11M062658


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTSF Gene:
Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic
system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active
mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a
C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide,
and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the
papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share
structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain
contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of
484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation
sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor
pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene
encoding cathepsin W. (provided by RefSeq, Jul 2008)

GeneCards Summary for CTSF Gene: 
CTSF (cathepsin F) is a protein-coding gene. Diseases associated with CTSF include clonorchiasis, and opisthorchiasis, and among its related super-pathways are Immune System and Kinesins. GO annotations related to this gene include cysteine-type endopeptidase activity. An important paralog of this gene is TINAG.

UniProtKB/Swiss-Prot: CATF_HUMAN, Q9UBX1
Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins.
Has also been implicated in tumor invasion and metastasis

Gene Wiki entry for CTSF (Cathepsin F) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTSF gene promoter:
         GR   USF1   Spz1   AP-1   CUTL1   CREB   deltaCREB   FOXO4   GR-alpha   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTSF promoter sequence
   Search SABiosciences Chromatin IP Primers for CTSF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

CTSF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSF gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M066332:  view genomic region     (about GC identifiers)

Start:
66,330,934 bp from pter      End:
66,336,312 bp from pter
Size:
5,379 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CATF_HUMAN, Q9UBX1 (See protein sequence)
Recommended Name: Cathepsin F precursor  
Size: 484 amino acids; 53366 Da
Subcellular location: Lysosome
2 PDB 3D structures from and Proteopedia for CTSF:
1D5U (3D)        1M6D (3D)    
Secondary accessions: B2R964 O95240 Q9NSU4 Q9UKQ5

Explore the universe of human proteins at neXtProt for CTSF: NX_Q9UBX1

Explore proteomics data for CTSF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBX1

  • 2 DME Specific Peptides for CTSF (Q9UBX1)
     CGSCWAF  FSDLTEEEF 

    CTSF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CTSF Protein Expression
    REFSEQ proteins: NP_003784.2  
    ENSEMBL proteins: 
     ENSP00000310832   ENSP00000434936   ENSP00000433082   ENSP00000435822  
    Reactome Protein details: Q9UBX1
    Human Recombinant Protein Products for CTSF: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for CTSF
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CTSF
    GenScript Custom Purified and Recombinant Proteins Services for CTSF
    Novus Biologicals CTSF Proteins
    Novus Biologicals CTSF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTSF 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome TAS9822672
    GO:0043202lysosomal lumen TAS--

    CTSF for ontologies           About GeneDecksing



    CTSF Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CTSF (Cathepsin F)
    OriGene Antibodies for CTSF
    OriGene Custom Antibody Services for CTSF
    GenScript Custom Superior Antibodies Services for CTSF
    Novus Biologicals CTSF Antibodies
    Abcam antibodies for CTSF
    Cloud-Clone Corp. Antibodies for CTSF 
    ThermoFisher Antibodies for CTSF
    LSBio Antibodies in human, mouse, rat for CTSF 

    Assay Products for CTSF: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CTSF
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CTSF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CTSF 
    Cloud-Clone Corp. CLIAs for CTSF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CTS: Cathepsins

    5 InterPro protein domains:
     IPR013128 Peptidase_C1A
     IPR000169 Pept_cys_AS
     IPR013201 Prot_inhib_I29
     IPR025660 Pept_his_AS
     IPR000668 Peptidase_C1A_C

    Graphical View of Domain Structure for InterPro Entry Q9UBX1

    ProtoNet protein and cluster: Q9UBX1

    2 Blocks protein domains:
    IPB000668 Papain cysteine protease (C1) family signature
    IPB013201 Proteinase inhibitor I29


    UniProtKB/Swiss-Prot: CATF_HUMAN, Q9UBX1
    Similarity: Belongs to the peptidase C1 family


    CTSF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATF_HUMAN, Q9UBX1
    Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins.
    Has also been implicated in tumor invasion and metastasis
    Catalytic activity: The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2,
    with high specificity constant (k(cat)/K(m)) comparable to that of cathepsin L

         Genatlas biochemistry entry for CTSF:
    cysteine proteinase,papain family,cathepsin F,widely expressed,involved in degradative processes during tumor
    progression,subgroup F-like protease

         Enzyme Numbers (IUBMB): EC 3.4.22.411 2 EC 3.4.222

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity TAS9822672
    GO:0008234cysteine-type peptidase activity ----
         
    CTSF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CTSF:
     Decreased Hepatitis C virus re 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ctsf):
     behavior/neurological  growth/size  mortality/aging  nervous system 

    CTSF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ctsftm1Hap for CTSF

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CTSF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTSF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTSF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTSF 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTSF
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CTSF:
    hsa-miR-3184 hsa-miR-137 hsa-miR-3065-3p hsa-miR-3065-5p hsa-miR-29c hsa-miR-29a hsa-miR-423-5p hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidCTSF 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CTSF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CTSF
    Sirion Biotech Customized adenovirus for overexpression of CTSF

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CTSF (see all 5)
    OriGene ORF clones in mouse, rat for CTSF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTSF (NM_003793)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSF
    Sirion Biotech Customized lentivirus for stable overexpression of CTSF 
                         Customized lentivirus expression plasmids for stable overexpression of CTSF 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CTSF
    Search LifeMap BioReagents cell lines for CTSF
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CTSF About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2MHC class II antigen presentation
    MHC class II antigen presentation0.32
    3Lysosome
    Lysosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for CTSF
        Adaptive Immune System
    Immune System
    MHC class II antigen presentation


    1         Kegg Pathway  (Kegg details for CTSF):
        Lysosome


    CTSF for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTSF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for CTSF (Q9UBX13 ENSP000003108324) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD74P042333, ENSP000000095304I2D: score=2 STRING: ENSP00000009530
    TAF12Q165143I2D: score=2 
    NCAM2O153943I2D: score=1 
    CTSSENSP000003579814STRING: ENSP00000357981
    HLA-DRB1ENSP000003530994STRING: ENSP00000353099
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    CTSF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CTSF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTSF (CATF)

    8 DrugBank Compounds for CTSF    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    4-Morpholin-4-Yl-Piperidine-1-Carboxylic Acid [1-(3-Benzenesulfonyl-1-Propyl-Allylcarbamoyl)-2-Phenylethyl]-Amide-- --target--17139284 17016423
    BENZOYL-TYROSINE-ALANINE-METHYL KETONE-- --target--10592235
    Benzoyl-Arginine-Alanine-Methyl Ketone-- --target--10592235
    HOMOPHENYLALANINYLMETHANE-- --target--10592235
    WRR-112-- --target--10592235
    WRR-99-- --target--10592235
    [1-(1-Benzyl-3-Hydroxy-2-Oxo-Propylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl Ester-- --target--10592235
    [1-(1-Methyl-4,5-Dioxo-Pent-2-Enylcarbamoyl)-2-Phenyl-Ethyl]-Carbamic Acid Benzyl Ester-- --target--10592235

    2 Novoseek inferred chemical compound relationships for CTSF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    divinyl sulfone 78.7 2 12225749 (1), 12454497 (1)
    cysteine 66.9 13 10318784 (4), 10198209 (3), 10661872 (1), 9822672 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about CTSF / CATF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CTSF gene: 
    NM_003793.3  

    Unigene Cluster for CTSF:

    Cathepsin F
    Hs.11590  [show with all ESTs]
    Unigene Representative Sequence: BC013359
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310325(uc001oip.3) ENST00000527141 ENST00000525733 ENST00000524994
    ENST00000530565 ENST00000529199 ENST00000529561 ENST00000533168 ENST00000526010

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTSF
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CTSF:
    hsa-miR-3184 hsa-miR-137 hsa-miR-3065-3p hsa-miR-3065-5p hsa-miR-29c hsa-miR-29a hsa-miR-423-5p hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidCTSF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CTSF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSF
    Clone
    Products:
         
    OriGene clones in human, mouse for CTSF (see all 5)
    OriGene ORF clones in mouse, rat for CTSF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTSF (NM_003793)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSF
    Sirion Biotech Customized lentivirus for stable overexpression of CTSF 
                         Customized lentivirus expression plasmids for stable overexpression of CTSF 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CTSF
    OriGene qSTAR qPCR primer pairs in human, mouse for CTSF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTSF
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSF

    Additional mRNA sequence: 

    AF071748.1 AF071749.1 AF088886.2 AF136279.1 AJ007331.1 AK313657.1 AL137742.1 BC011682.2 
    BC013359.2 BC036451.1 CR541680.1 

    6 DOTS entries:

    DT.111592  DT.100817827  DT.95281684  DT.92428022  DT.92428023  DT.95099455 

    24/210 AceView cDNA sequences (see all 210):

    AA937142 BQ575903 CR541680 BQ005952 BU734302 BQ575103 BX451495 AA323194 
    BM712529 BE501402 AA478441 AL137742 AI640129 CB269409 BM673807 AI081060 
    AI813436 BF727319 AA322096 AI640362 BM971582 BM716355 BM710498 BM723542 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CTSF (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:                    -                                                                                                               
    SP2:                                                                                                                                    
    SP3:        -           -                                                                                                               
    SP4:                                      -                                                                                             
    SP5:                                                                                            -                                       


    ECgene alternative splicing isoforms for CTSF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTSF expression in normal human tissues (normalized intensities)      CTSF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAGGAAAC
    CTSF Expression
    About this image


    CTSF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem progenitor RP1-MV2-16
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See CTSF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTSF

    SOURCE GeneReport for Unigene cluster: Hs.11590

    UniProtKB/Swiss-Prot: CATF_HUMAN, Q9UBX1
    Tissue specificity: High expression levels in heart, skeletal muscle, brain, testis and ovary; moderate levels in
    prostate, placenta, liver and colon; and no detectable expression in peripheral leukocytes and thymus

        SABiosciences Custom PCR Arrays for CTSF
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CTSF
    OriGene qSTAR qPCR primer pairs in human, mouse for CTSF
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTSF
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSF
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CTSF gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctsf1 , 5 cathepsin F1, 5 82.03(n)1
    78.48(a)1
      19 (4.12 cM)5
    564641  NM_019861.11  NP_063914.11 
     48551295 
    zebrafish
    (Danio rerio)
    Actinopterygii ctsf1 cathepsin F 56.92(n)
    52.9(a)
      565588  NM_001077568.1  NP_001071036.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG121633 cathepsin F 45(a)   82F7   --
    worm
    (Caenorhabditis elegans)
    Secernentea F41E6.63
    tag-1961
    cysteine protease and a protease
    inhibitor3
    Protein TAG-1961
    45(a)
    (best of 3)3
    52.35(n)1
    49.66(a)1
      V(8597514-8599945)3
    1792401  NM_072814.21  NP_505215.21 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G549401 Papain family cysteine protease 48.92(n)
    47.44(a)
      824659  NM_115351.6  NP_567010.5 
    rice
    (Oryza sativa)
    Liliopsida Os07g04809001 hypothetical protein 53.58(n)
    47.44(a)
      4343231  NM_001066174.1  NP_001059639.1 


    ENSEMBL Gene Tree for CTSF (if available)
    TreeFam Gene Tree for CTSF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTSF gene
    TINAG2  CTSO2  CTSW2  CTSK2  CTSV2  CTSB2  CTSS2  CTSH2  
    CTSC2  TINAGL12  CTSZ2  CTSL2  
    9 SIMAP similar genes for CTSF using alignment to 5 protein entries:     CATF_HUMAN (see all proteins):
    DKFZp686B24257    CTSW    CTSH    CTSL1    CTSS    CTSL2
    CTSO    CTSL    CTSK

    CTSF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/203 SNPs in CTSF are shown (see all 203)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154673741,2
    C,F--66253159(+) ACAGAT/CGCAAG 1 -- int11Minor allele frequency- C:0.05WA 118
    rs46303091,2
    C,F,H--66253375(+) CCCCCC/AATTAT 1 -- int1 trp323Minor allele frequency- A:0.22NS EA NA WA CSA 2635
    rs1898620701,2
    C--66253484(+) CAAGCC/TGCCCA 2 S G mis10--------
    rs2022424981,2
    --66253574(+) TAGGCC/TGGGGA 1 -- int10--------
    rs2020500531,2
    C,F--66253577(+) GCTGGG/AGACAG 1 -- int11Minor allele frequency- A:0.00EU 593
    rs1147276601,2
    C,F--66253630(+) AGGGTC/TCCCTG 2 G syn12Minor allele frequency- T:0.01WA NA 4666
    rs2014898351,2
    --66253719(+) GGTGGA/TGTTGG 1 -- int10--------
    rs2004233551,2
    C--66253735(+) GAGCCA/GGGCCC 1 -- int10--------
    rs1150775911,2
    C--66253752(+) CAGCCC/TCAGTG 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1473982261,2
    F--66253853(+) GGGGCG/AAGGTC 2 /L syn11Minor allele frequency- A:0.00NA 4552

    HapMap Linkage Disequilibrium report for CTSF (66330934 - 66336312 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CTSF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897788CNV Loss21882294
    nsv897787CNV Loss21882294
    nsv522277CNV Loss19592680
    dgv1187n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): CTSF
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CTSF
    DNA2.0 Custom Variant and Variant Library Synthesis for CTSF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603539    OMIM disorders: --

    10 diseases for CTSF:    About MalaCards
    clonorchiasis    opisthorchiasis    keratoconus    keratopathy
    bipolar disorder    osteosarcoma    cervical cancer    cervicitis
    prostate cancer    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for CTSF:
    Clonorchiasis     Keratopathy

    CTSF for disorders           About GeneDecksing

    Genetic Association Database (GAD): CTSF
    Human Genome Epidemiology (HuGE) Navigator: CTSF (3 documents)

    Export disorders for CTSF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTSF gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with CTSF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain. (PubMed id 10318784)1, 2, 3, 9 Santamaria I.... Lopez-Otin C. (1999)
    2. Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. (PubMed id 9822672)1, 2, 3, 9 Wang B.... Broemme D. (1998)
    3. Human cathepsins F and W: a new subgroup of cathepsins. (PubMed id 10362521)1, 2, 9 Wex T.... Bromme D. (1999)
    4. Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen. (PubMed id 10198209)1, 2, 9 Naegler D.K.... Menard R. (1999)
    5. The human cathepsin F gene -- a fusion product between an ancestral cathepsin and cystatin gene. (PubMed id 10661872)1, 2, 9 Wex T.... Broemme D. (1999)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. (PubMed id 19416921)1, 4 Scott L.J....Boehnke M. (2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Mouse cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene. (PubMed id 10876093)1, 9 Deussing J....Peters C. (2000)
    10. Cysteine protease cathepsin F is expressed in human atherosclerotic lesions, is secreted by cultured macrophages, and modifies low density lipoprotein particles in vitro. (PubMed id 15184381)1, 9 Oorni K....Kovanen P.T. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8722 HGNC: 2531 AceView: CTSF Ensembl:ENSG00000174080 euGenes: HUgn8722
    ECgene: CTSF Kegg: 8722 H-InvDB: CTSF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTSF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CTSF gene:
    Search GeneIP for patents involving CTSF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CTSF (Cathepsin F)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CTSF   OriGene RNAi products in human, mouse, rat for CTSF  
     OriGene qPCR primer pairs and template standards for CTSF   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CTSF  
     OriGene qSTAR qPCR primer pairs in human, mouse for CTSF   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CTSF   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CTSF   OriGene Custom Protein Services for CTSF  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTSF
     QIAGEN SeqTarget long-range PCR primers for resequencing CTSF
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSF
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSF
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSF
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSF
     GenScript Custom Purified and Recombinant Proteins Services for CTSF GenScript cDNA clones with any tag delivered in your preferred vector for CTSF
     GenScript Custom Assay Services for CTSF GenScript Custom Superior Antibodies Services for CTSF
     GenScript Custom overexpressing Cell Line Services for CTSF CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CTSF promoter
     Search Chromatin IP Primers for CTSF
     RT2 qPCR Primer Assay in human, mouse, rat CTSF
     Search GNC Networks for CTSF
     SABiosciences Custom PCR Arrays for CTSF
     Search Tocris compounds for CTSF (CATF)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for CTSF
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CTSF antibodies
     CTSF proteins
     CTSF lysates
     Antibodies for CTSF
     See all of Abcam's Antibodies, Kits and Proteins for CTSF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CTSF
     Antibodies for CTSF
     ELISAs for CTSF
     CLIAs for CTSF
     Search LifeMap BioReagents cell lines for CTSF
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSF
     SwitchGear 3'UTR luciferase reporter plasmids for CTSF
     SwitchGear Promoter luciferase reporter plasmids for CTSF
     ThermoFisher Antibodies for CTSF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSF
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CTSF
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTSF
    Customized:
     lentivirus for stable overexpression of CTSF
     lentivirus expression plasmids for stable overexpression of CTSF
     adenovirus for overexpression of CTSF
     LSBio Antibodies in human, mouse, rat for CTSF
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CTSF gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4