Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CTSF Gene

Aliases for CTSF Gene

  • Cathepsin F 2 3
  • EC 4 63
  • CLN13 3 6
  • CATSF 3 4
  • EC 3.4.22 63

External Ids for CTSF Gene

Previous GeneCards Identifiers for CTSF Gene

  • GC11M068865
  • GC11M068012
  • GC11M066580
  • GC11M066106
  • GC11M066088
  • GC11M066332
  • GC11M062658

Summaries for CTSF Gene

Entrez Gene Summary for CTSF Gene

  • Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTSF Gene

CTSF (Cathepsin F) is a Protein Coding gene. Diseases associated with CTSF include ceroid lipofuscinosis, neuronal, 13, kufs type and adult neuronal ceroid lipofuscinosis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Lysosome. GO annotations related to this gene include cysteine-type endopeptidase activity. An important paralog of this gene is CTSW.

UniProtKB/Swiss-Prot for CTSF Gene

  • Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis

Gene Wiki entry for CTSF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSF Gene

Genomics for CTSF Gene

Regulatory Elements for CTSF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTSF Gene

66,563,463 bp from pter
66,568,841 bp from pter
5,379 bases
Minus strand

Genomic View for CTSF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTSF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSF Gene

Proteins for CTSF Gene

  • Protein details for CTSF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathepsin F
    Protein Accession:
    Secondary Accessions:
    • B2R964
    • O95240
    • Q9NSU4
    • Q9UKQ5

    Protein attributes for CTSF Gene

    484 amino acids
    Molecular mass:
    53366 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTSF Gene

neXtProt entry for CTSF Gene

Proteomics data for CTSF Gene at MOPED

Selected DME Specific Peptides for CTSF Gene

Post-translational modifications for CTSF Gene

  • Glycosylation at Asn160, Asn195, Asn367, Asn378, and Asn440
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSF Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for CTSF Gene

Gene Families for CTSF Gene

Suggested Antigen Peptide Sequences for CTSF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C1 family.
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSF: view

Function for CTSF Gene

Molecular function for CTSF Gene

GENATLAS Biochemistry:
cysteine proteinase,papain family,cathepsin F,widely expressed,involved in degradative processes during tumor progression,subgroup F-like protease
UniProtKB/Swiss-Prot CatalyticActivity:
The recombinant enzyme cleaves synthetic substrates with Phe and Leu (better than Val) in P2, with high specificity constant (k(cat)/K(m)) comparable to that of cathepsin L
UniProtKB/Swiss-Prot Function:
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis

Enzyme Numbers (IUBMB) for CTSF Gene

Gene Ontology (GO) - Molecular Function for CTSF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity TAS 9822672
GO:0008234 cysteine-type peptidase activity --
genes like me logo Genes that share ontologies with CTSF: view
genes like me logo Genes that share phenotypes with CTSF: view

Animal Models for CTSF Gene

MGI Knock Outs for CTSF:

Animal Model Products

miRNA for CTSF Gene

miRTarBase miRNAs that target CTSF

No data available for Transcription Factor Targeting and HOMER Transcription for CTSF Gene

Localization for CTSF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSF Gene


Subcellular locations from

Jensen Localization Image for CTSF Gene COMPARTMENTS Subcellular localization image for CTSF gene
Compartment Confidence
lysosome 5
vacuole 5
extracellular 3

Gene Ontology (GO) - Cellular Components for CTSF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome TAS 9822672
GO:0031982 vesicle IDA 24769233
GO:0043202 lysosomal lumen TAS --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with CTSF: view

Pathways for CTSF Gene

genes like me logo Genes that share pathways with CTSF: view

Pathways by source for CTSF Gene

2 Reactome pathways for CTSF Gene
1 KEGG pathway for CTSF Gene

Gene Ontology (GO) - Biological Process for CTSF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008219 cell death --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with CTSF: view

Compounds for CTSF Gene

(3) ApexBio Compounds for CTSF Gene

Compound Action Cas Number
E-64-c Inhibitor of cysteine proteinases [76684-89-4]
Odanacatib (MK-0822) "Cathepsin K,potent and selective" [603139-19-1]
Papain Inhibitor Inhibitor of peptidase activity of Papain [70195-20-9]

(2) Novoseek inferred chemical compound relationships for CTSF Gene

Compound -log(P) Hits PubMed IDs
divinyl sulfone 78.7 2
cysteine 66.9 13
genes like me logo Genes that share compounds with CTSF: view

Compound Products

Transcripts for CTSF Gene

Unigene Clusters for CTSF Gene

Cathepsin F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTSF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: -
SP3: - -
SP4: -
SP5: -

Relevant External Links for CTSF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSF Gene

mRNA expression in normal human tissues for CTSF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CTSF Gene

This gene is overexpressed in Serum (31.0), Vitreous humor (17.9), and Plasma (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CTSF Gene

SOURCE GeneReport for Unigene cluster for CTSF Gene Hs.11590

mRNA Expression by UniProt/SwissProt for CTSF Gene

Tissue specificity: High expression levels in heart, skeletal muscle, brain, testis and ovary; moderate levels in prostate, placenta, liver and colon; and no detectable expression in peripheral leukocytes and thymus
genes like me logo Genes that share expressions with CTSF: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for CTSF Gene

Orthologs for CTSF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTSF 35
  • 86.33 (n)
  • 82 (a)
  • 82 (a)
(Canis familiaris)
Mammalia CTSF 35
  • 86.98 (n)
  • 84.65 (a)
  • 83 (a)
(Mus musculus)
Mammalia Ctsf 35
  • 82.8 (n)
  • 79.55 (a)
Ctsf 16
Ctsf 36
  • 78 (a)
(Pan troglodytes)
Mammalia CTSF 35
  • 98.76 (n)
  • 98.14 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Ctsf 35
  • 82.39 (n)
  • 78.23 (a)
(Monodelphis domestica)
Mammalia CTSF 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctsf 35
  • 65.48 (n)
  • 64.94 (a)
(Danio rerio)
Actinopterygii ctsf 35
  • 56.87 (n)
  • 53.47 (a)
ctsf 36
  • 48 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12546 35
fruit fly
(Drosophila melanogaster)
Insecta CG12163 37
  • 45 (a)
CG12163 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea F41E6.6 37
  • 45 (a)
R07E3.1 37
  • 35 (a)
R09F10.1 37
  • 34 (a)
tag-196 35
  • 52.35 (n)
  • 49.66 (a)
tag-196 36
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G54940 35
  • 48.33 (n)
  • 46.67 (a)
(Hordeum vulgare)
Liliopsida Hv.4417 35
(Oryza sativa)
Liliopsida Os07g0480900 35
  • 53.58 (n)
  • 47.44 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1645 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2594 36
  • 63 (a)
Species with no ortholog for CTSF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSF Gene

Gene Tree for CTSF (if available)
Gene Tree for CTSF (if available)

Paralogs for CTSF Gene

Paralogs for CTSF Gene

(9) SIMAP similar genes for CTSF Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CTSF: view

Variants for CTSF Gene

Sequence variations from dbSNP and Humsavar for CTSF Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs545009 -- 66,566,127(-) CTGAG(A/G/T)AAAGA synonymous-codon, reference, missense
rs572846 -- 66,563,987(-) CATCG(C/T)GGGTC synonymous-codon, reference
rs615205 -- 66,570,516(-) aatca(A/G)tctca upstream-variant-2KB
rs630021 -- 66,569,518(-) GTGAG(A/C)CACTG upstream-variant-2KB
rs654200 -- 66,564,516(-) CACAG(C/G)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTSF Gene

Variant ID Type Subtype PubMed ID
dgv1187n71 CNV Loss 21882294
nsv522277 CNV Loss 19592680
nsv897787 CNV Loss 21882294
nsv897788 CNV Loss 21882294

Relevant External Links for CTSF Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSF Gene

Disorders for CTSF Gene

(1) OMIM Diseases for CTSF Gene (603539)


  • Ceroid lipofuscinosis, neuronal, 13 (CLN13) [MIM:615362]: A form of neuronal ceroid lipofuscinosis characterized by adult onset of progressive cognitive decline and motor dysfunction leading to dementia and often early death. Some patients develop seizures. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. {ECO:0000269 PubMed:23297359}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for CTSF Gene

Relevant External Links for CTSF

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CTSF: view

No data available for Novoseek inferred disease relationships and Genatlas for CTSF Gene

Publications for CTSF Gene

  1. Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain. (PMID: 10318784) Santamaria I. … Lopez-Otin C. (J. Biol. Chem. 1999) 2 3 4 23
  2. Human cathepsin F. Molecular cloning, functional expression, tissue localization, and enzymatic characterization. (PMID: 9822672) Wang B. … Broemme D. (J. Biol. Chem. 1998) 2 3 4 23
  3. Full-length cDNA of human cathepsin F predicts the presence of a cystatin domain at the N-terminus of the cysteine protease zymogen. (PMID: 10198209) Naegler D.K. … Menard R. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  4. Human cathepsins F and W: a new subgroup of cathepsins. (PMID: 10362521) Wex T. … Bromme D. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  5. The human cathepsin F gene -- a fusion product between an ancestral cathepsin and cystatin gene. (PMID: 10661872) Wex T. … Broemme D. (Biol. Chem. 1999) 3 4 23

Products for CTSF Gene

Sources for CTSF Gene

Back to Top