CTSE Gene

Aliases
for CTSE gene

Previous GC identifers: GC01U990032 GC01P202860 GC01P204484 GC01P177247

Summaries
for CTSE gene

Genomic Views
for CTSE gene

RefSeq DNA sequence:

NC_000001.10  NT_086602.2  

SwitchGear Promoter luciferase reporter plasmid: CTSE promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTSE

CTSE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206319:  view genomic region     (about GC identifiers)

Proteins
for CTSE gene

2 PDB 3D structures from and Proteopedia for CTSE:

1LCG (3D)        1TZS (3D)    

Explore the universe of human proteins at neXtProt for CTSE: NX_P14091

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CTSE (Cathepsin E)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): CTSE OriGene Custom Protein Services for CTSE
	GenScript Custom Purified and Recombinant Proteins Services for CTSE
	Novus Biologicals CTSE Protein Novus Biologicals CTSE Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CTSE

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for CTSE (Cathepsin E)
	OriGene Antibodies: CTSE OriGene Custom Antibody Services for CTSE
	GenScript Custom Superior Antibodies Services for CTSE
	Novus Biologicals CTSE Antibodies
	Search for Antibodies for CTSE at Abcam
	Uscn Antibodies for CTSE
	ThermoFisher Antibodies for CTSE

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for CTSE (Cathepsin E)
	GenScript CTSE-Activity-based Protease Assay for Compound Screening
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CTSE

Protein Domains /
Families
for CTSE gene

ProtoNet protein and cluster: P14091

Function
for CTSE gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CTSE Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTSE
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CTSE:
		hsa-miR-3671 hsa-miR-3650 hsa-miR-607 hsa-miR-4306 hsa-miR-1270 hsa-miR-620 hsa-miR-185 hsa-miR-3919
		SwitchGear 3'UTR luciferase reporter plasmid: CTSE 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTSE (see all 7) OriGene shRNA RFP: CTSE OriGene siRNA: CTSE
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTSE

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CTSE

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTSE (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTSE (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CTSE (NM_148964)
		Sino Biological Human cDNA Clone for CTSE
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSE
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSE

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CTSE
		Search LifeMap BioReagents cell lines for CTSE

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSE

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Ctse)

Pathways & Interactions
for CTSE gene

	Super-pathway	contained gene-specific pathways
1	Immune System	Immune System 1.00 Adaptive Immune System 0.59
2	Lysosome	Lysosome 1.00
3	MHC class II antigen presentation	MHC class II antigen presentation 1.00

3        Reactome Pathways for CTSE

	Adaptive Immune System
	Immune System
	MHC class II antigen presentation

1         Kegg Pathway  (Kegg details for CTSE)

Lysosome

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for CTSE gene

Transcripts
for CTSE gene

Expression
for CTSE gene

CTSE expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	KidneyRenal Collecting Duct System			Kidney
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Endoderm progenitor-like cells (Generation and expan...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTSE Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTSE
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTSE
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTSE

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSE

Orthologs
for CTSE gene

Paralogs
for CTSE gene

Paralogs for CTSE gene

BACE1²  CTSD²  PGA3²  BACE2²  NAPSA²  ENSG00000250644²  PGC²  PGA5²  

ENSG00000265969²  REN²  PGA4²  

8 SIMAP similar genes for CTSE using alignment to 3 protein entries:     CATE_HUMAN (see all proteins):

PGA3    PGA4    DKFZp666J2410    PGA5    PGC    CTSD

NAPSA    REN

CTSE for paralogs           About GeneDecksing

Genomic Variants
for CTSE gene

10/349 NCBI SNPs in CTSE are shown (see all 349)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs286199551,2	C,F,H,	--	177246234(+)	GAAAGA/GTCAAC	2	--	us2k1 tfbs3		18		NS NA WA CSA	1886
rs285317941,2	C,F,H,	--	177246356(+)	CCAAGG/AGTGGG	2	--	us2k1		14		NS NA WA CSA	1366
rs618167701,2		--	177246675(+)	CTGATG/TGTGAG	2	--	us2k1		1		NA	2
rs2018913711,2	C	--	177246821(+)	ATGTTC/GANNNN	2	--	us2k1		0	--	--	--	--
rs778587121,2		--	177246855(+)	TGACTA/GTATTT	2	--	us2k1		0	--	--	--	--
rs1119608151,2	C,	--	177246914(+)	GTGGGC/TCCTAC	2	--	us2k1		1		NA	2
rs754753011,2	F,	--	177247142(+)	CTTTGT/CCATGG	2	--	us2k1		1		WA	118
rs755790191,2	F,	--	177247261(+)	TCATCA/CAGTCC	2	--	us2k1		1		WA	118
rs577136921,2	C,F,	--	177247510(+)	GCACTT/CGCAGT	2	--	us2k1		8		WA NA CSA	249
rs557536281,2	C,F,	--	177247605(+)	GCCAAA/GGCCCT	2	--	us2k1		5		WA NA CSA	126

HapMap Linkage Disequilibrium report for CTSE (206317459 - 206332104 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CTSE: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTSE

DNA2.0 Custom Variant and Variant Library Synthesis for CTSE

Disorders / Diseases
for CTSE gene

20 diseases for CTSE

10/18 Novoseek disease relationships for CTSE gene (see all 18)    About this table

Publications
for CTSE gene

PubMed articles for CTSE gene, integrated from 9 sources (see all 138): (articles sorted by number of sources associating them with CTSE)

Utopia: connect your pdf to the dynamic world of online information

1. Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases. (PubMed id 2674141)^{1, 2, 3} Azuma T.... Taggart R.T. (1989)
2. Human gastric cathepsin E gene. Multiple transcripts result from alternative polyadenylation of the primary transcripts of a single gene locus at 1q31-q32. (PubMed id 1370478)^{1, 2, 9} Azuma T.... Taggart R.T. (1992)
3. Regulation of cathepsin E expression during human B cell differentiation in vitro. (PubMed id 8765029)^{1, 2, 9} Sealy L.... Chain B. (1996)
4. Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids. (PubMed id 2369841)^{1, 3, 9} Couvreur J.M....Taggart R.T. (1990)
5. An alternatively spliced variant of cathepsin E in human gastric adenocarcinoma cells. (PubMed id 12531480)^{1, 2, 9} Tatnell P.J.... Kay J. (2003)
6. Regulation of human and mouse procathepsin E gene expression. (PubMed id 11322887)^{1, 2, 9} Cook M.... Tatnell P.J. (2001)
7. Monomeric human cathepsin E. (PubMed id 7789521)^{1, 2, 9} Fowler S.D.... Tatnell P.J. (1995)
8. Structural evidence for two isozymic forms and the carbohydrate attachment site of human gastric cathepsin E. (PubMed id 2334440)^{1, 2, 9} Athauda S.B.P.... Takahashi K. (1990)
9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
10. Subcellular localization and targeting of cathepsin E. (PubMed id 7983070)^{1, 2} Finley E.M. and Kornfeld S. (1994)

External Searches for CTSE gene

Genome Databases showing CTSE gene

Other Databases showing CTSE gene

Specialized Databases showing CTSE gene

Products
for CTSE gene