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Aliases for CTSE Gene

Aliases for CTSE Gene

  • Cathepsin E 2 3 5
  • EC 4 63
  • Erythrocyte Membrane Aspartic Proteinase 3
  • Slow-Moving Proteinase 3
  • EC 3.4.23 63
  • CATE 3

External Ids for CTSE Gene

Previous GeneCards Identifiers for CTSE Gene

  • GC01U990032
  • GC01P202860
  • GC01P204484
  • GC01P206319
  • GC01P177247

Summaries for CTSE Gene

Entrez Gene Summary for CTSE Gene

  • This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]

GeneCards Summary for CTSE Gene

CTSE (Cathepsin E) is a Protein Coding gene. Diseases associated with CTSE include Gastric Adenocarcinoma and Pancreatic Ductal Adenocarcinoma. Among its related pathways are Immune System and Lysosome. GO annotations related to this gene include protein homodimerization activity and aspartic-type endopeptidase activity. An important paralog of this gene is REN.

UniProtKB/Swiss-Prot for CTSE Gene

  • May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

Gene Wiki entry for CTSE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSE Gene

Genomics for CTSE Gene

Regulatory Elements for CTSE Gene

Enhancers for CTSE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CTSE on UCSC Golden Path with GeneCards custom track

Genomic Location for CTSE Gene

206,009,264 bp from pter
206,023,909 bp from pter
14,646 bases
Minus strand

Genomic View for CTSE Gene

Genes around CTSE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSE Gene

Proteins for CTSE Gene

  • Protein details for CTSE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathepsin E
    Protein Accession:
    Secondary Accessions:
    • Q5TZ01
    • Q5TZ02
    • Q9NY58
    • Q9UCE3
    • Q9UCE4

    Protein attributes for CTSE Gene

    401 amino acids
    Molecular mass:
    43312 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for CTSE Gene

    Alternative splice isoforms for CTSE Gene


neXtProt entry for CTSE Gene

Proteomics data for CTSE Gene at MOPED

Post-translational modifications for CTSE Gene

  • Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.
  • Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57.
  • Glycosylation at Asn 90
  • Modification sites at PhosphoSitePlus

Other Protein References for CTSE Gene

Antibody Products

Domains & Families for CTSE Gene

Gene Families for CTSE Gene

Suggested Antigen Peptide Sequences for CTSE Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase A1 domain.
  • Belongs to the peptidase A1 family.
  • Contains 1 peptidase A1 domain.
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with CTSE: view

Function for CTSE Gene

Molecular function for CTSE Gene

GENATLAS Biochemistry:
cathepsin E,aspartic proteinase
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.06 mM for hemoglobin {ECO:0000269 PubMed:8346912}; KM=0.13 mM for Pro-Pro-Thr-Ile-Phe-Phe(4-NO2)-Arg-Leu {ECO:0000269 PubMed:8346912}; KM=0.04 mM for Lys-Pro-Ile-Glu-Phe-Phe(4-NO2)-Arg-Leu {ECO:0000269 PubMed:8346912};
UniProtKB/Swiss-Prot CatalyticActivity:
Similar to cathepsin D, but slightly broader specificity.
UniProtKB/Swiss-Prot Function:
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

Enzyme Numbers (IUBMB) for CTSE Gene

genes like me logo Genes that share phenotypes with CTSE: view

Animal Models for CTSE Gene

MGI Knock Outs for CTSE:

Animal Model Products

  • Taconic Biosciences Mouse Models for CTSE

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSE Gene

Localization for CTSE Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSE Gene

Endosome. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.

Subcellular locations from

Jensen Localization Image for CTSE Gene COMPARTMENTS Subcellular localization image for CTSE gene
Compartment Confidence
lysosome 4
vacuole 4
endosome 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for CTSE Gene

Pathways & Interactions for CTSE Gene

genes like me logo Genes that share pathways with CTSE: view

Pathways by source for CTSE Gene

1 GeneTex pathway for CTSE Gene
1 KEGG pathway for CTSE Gene

Gene Ontology (GO) - Biological Process for CTSE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016540 protein autoprocessing IEA --
genes like me logo Genes that share ontologies with CTSE: view

No data available for SIGNOR curated interactions for CTSE Gene

Drugs & Compounds for CTSE Gene

(4) Drugs for CTSE Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CTSE Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTSE: view

Transcripts for CTSE Gene

Unigene Clusters for CTSE Gene

Cathepsin E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTSE Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2: - -
SP4: - -

Relevant External Links for CTSE Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSE Gene

mRNA expression in normal human tissues for CTSE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSE Gene

This gene is overexpressed in Stomach (x41.1) and Lung (x6.0).

Protein differential expression in normal tissues from HIPED for CTSE Gene

This gene is overexpressed in Stomach (42.8), Cardia (17.1), and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CTSE Gene

SOURCE GeneReport for Unigene cluster for CTSE Gene Hs.644082

mRNA Expression by UniProt/SwissProt for CTSE Gene

Tissue specificity: Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.
genes like me logo Genes that share expression patterns with CTSE: view

Primer Products

No data available for Protein tissue co-expression partners for CTSE Gene

Orthologs for CTSE Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTSE Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia CTSE 35
  • 87.12 (n)
  • 88.89 (a)
  • 89 (a)
(Mus musculus)
Mammalia Ctse 35
  • 83.33 (n)
  • 82.98 (a)
Ctse 16
Ctse 36
  • 83 (a)
(Pan troglodytes)
Mammalia CTSE 35
  • 99.58 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ctse 35
  • 84.39 (n)
  • 84.77 (a)
(Monodelphis domestica)
Mammalia CTSE 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
-- 36
  • 35 (a)
(Gallus gallus)
Aves CTSE 35
  • 69.94 (n)
  • 70.03 (a)
  • 68 (a)
(Anolis carolinensis)
Reptilia CTSE 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctse 35
  • 67.2 (n)
  • 71.58 (a)
(Danio rerio)
Actinopterygii nots 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10104 37
  • 39 (a)
CG13095 37
  • 45 (a)
CG17134 37
  • 42 (a)
CG17283 37
  • 40 (a)
CG5860 37
  • 36 (a)
CG5863 37
  • 42 (a)
CG6508 37
  • 40 (a)
pcl 37
  • 43 (a)
Bace 36
  • 44 (a)
CG17134 36
  • 41 (a)
CG17283 36
  • 31 (a)
CG31661 36
  • 32 (a)
CG31926 36
  • 32 (a)
CG31928 36
  • 31 (a)
CG33128 36
  • 38 (a)
CG5860 36
  • 33 (a)
CG5863 36
  • 39 (a)
CG6508 36
  • 35 (a)
pcl 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea asp-2 37
  • 34 (a)
asp-3 37
  • 42 (a)
asp-4 37
  • 45 (a)
asp-5 37
  • 33 (a)
asp-6 37
  • 34 (a)
C11D2.2 37
  • 34 (a)
C15C8.3 37
  • 32 (a)
F21F8.4 37
  • 32 (a)
F28A12.4 37
  • 30 (a)
F59D6.2 37
  • 29 (a)
F59D6.3 37
  • 32 (a)
Y39B6A.21 37
  • 35 (a)
Y39B6A.22 37
  • 29 (a)
Y39B6A.23 37
  • 33 (a)
Y39B6A.24 37
  • 31 (a)
asp-1 36
  • 33 (a)
asp-10 36
  • 30 (a)
asp-12 36
  • 32 (a)
asp-13 36
  • 26 (a)
asp-14 36
  • 19 (a)
asp-15 36
  • 28 (a)
asp-16 36
  • 31 (a)
asp-17 36
  • 32 (a)
asp-18 36
  • 31 (a)
asp-19 36
  • 27 (a)
asp-2 36
  • 20 (a)
asp-5 36
  • 31 (a)
asp-6 36
  • 31 (a)
asp-7 36
  • 28 (a)
asp-8 36
  • 23 (a)
asp-9 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP4 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10126 36
  • 43 (a)
Species with no ortholog for CTSE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSE Gene

Gene Tree for CTSE (if available)
Gene Tree for CTSE (if available)

Paralogs for CTSE Gene

Paralogs for CTSE Gene

(8) SIMAP similar genes for CTSE Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTSE: view

Variants for CTSE Gene

Sequence variations from dbSNP and Humsavar for CTSE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6503 - 206,012,363(+) TGTCA(C/T)CTTCA reference, missense
rs57621203 - 206,022,249(-) GCACT(A/C/G)TCTCC reference, missense
rs28402776 -- 206,019,743(-) TATAT(A/G)TAAGA intron-variant
rs28410805 -- 206,014,870(-) ATGAC(A/G)GCACT intron-variant
rs28765494 -- 206,018,722(-) AGAAC(A/G)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTSE Gene

Variant ID Type Subtype PubMed ID
nsv873123 CNV Gain 21882294

Variation tolerance for CTSE Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CTSE Gene

Disorders for CTSE Gene

MalaCards: The human disease database

(2) MalaCards diseases for CTSE Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastric adenocarcinoma
  • adenocarcinoma of stomach
pancreatic ductal adenocarcinoma
  • ductal adenocarcinoma of the pancreas
- elite association - COSMIC cancer census association via MalaCards
Search CTSE in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTSE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CTSE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSE Gene

Publications for CTSE Gene

  1. Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases. (PMID: 2674141) Azuma T. … Taggart R.T. (J. Biol. Chem. 1989) 2 3 4 67
  2. Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids. (PMID: 2369841) Couvreur J.M. … Taggart R.T. (Cytogenet. Cell Genet. 1990) 2 3 23
  3. Over-expression of cathepsin E and trefoil factor 1 in sessile serrated adenomas of the colorectum identified by gene expression analysis. (PMID: 19172291) Caruso M. … Ruszkiewicz A. (Virchows Arch. 2009) 3 23
  4. Cathepsin E regulates the presentation of tetanus toxin C-fragment in PMA activated primary human B cells. (PMID: 18996084) Burster T. … Kalbacher H. (Biochem. Biophys. Res. Commun. 2008) 3 23
  5. Regulation of the human cathepsin E gene by the constitutive androstane receptor. (PMID: 17888866) Page J.L. … Omiecinski C.J. (Arch. Biochem. Biophys. 2007) 3 23

Products for CTSE Gene

Sources for CTSE Gene