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Aliases for CTSE Gene

Aliases for CTSE Gene

  • Cathepsin E 2 3
  • EC 3.4.23.34 4 63
  • Erythrocyte Membrane Aspartic Proteinase 3
  • Slow-Moving Proteinase 3
  • EC 3.4.23 63
  • CATE 3

External Ids for CTSE Gene

Summaries for CTSE Gene

Entrez Gene Summary for CTSE Gene

  • The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTSE Gene

CTSE (Cathepsin E) is a Protein Coding gene. Diseases associated with CTSE include pancreatic cancer. Among its related pathways are Class I MHC mediated antigen processing and presentation and Lysosome. GO annotations related to this gene include protein homodimerization activity and aspartic-type endopeptidase activity. An important paralog of this gene is BACE1.

UniProtKB/Swiss-Prot for CTSE Gene

  • May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

Gene Wiki entry for CTSE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSE Gene

Genomics for CTSE Gene

Genomic Location for CTSE Gene

Start:
206,009,264 bp from pter
End:
206,023,909 bp from pter
Size:
14,646 bases
Orientation:
Minus strand

Genomic View for CTSE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTSE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSE Gene

Regulatory Elements for CTSE Gene

Proteins for CTSE Gene

  • Protein details for CTSE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14091-CATE_HUMAN
    Recommended name:
    Cathepsin E
    Protein Accession:
    P14091
    Secondary Accessions:
    • Q5TZ01
    • Q5TZ02
    • Q9NY58
    • Q9UCE3
    • Q9UCE4

    Protein attributes for CTSE Gene

    Size:
    401 amino acids
    Molecular mass:
    43312 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for CTSE Gene

    Alternative splice isoforms for CTSE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTSE Gene

Proteomics data for CTSE Gene at MOPED

Post-translational modifications for CTSE Gene

  • Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.
  • Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57
  • Glycosylation at Asn90

Other Protein References for CTSE Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CTSE Gene

Gene Families for CTSE Gene

HGNC:
  • CTS :Cathepsins

Suggested Antigen Peptide Sequences for CTSE Gene

Graphical View of Domain Structure for InterPro Entry

P14091

UniProtKB/Swiss-Prot:

CATE_HUMAN
Family:
  • Belongs to the peptidase A1 family.:
    • P14091
genes like me logo Genes that share domains with CTSE: view

Function for CTSE Gene

Molecular function for CTSE Gene

GENATLAS Biochemistry: cathepsin E,aspartic proteinase
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.06 mM for hemoglobin {ECO:0000269 PubMed:8346912}; KM=0.13 mM for Pro-Pro-Thr-Ile-Phe-Phe(4-NO2)-Arg-Leu {ECO:0000269 PubMed:8346912}; KM=0.04 mM for Lys-Pro-Ile-Glu-Phe-Phe(4-NO2)-Arg-Leu {ECO:0000269 PubMed:8346912};
UniProtKB/Swiss-Prot CatalyticActivity: Similar to cathepsin D, but slightly broader specificity.
UniProtKB/Swiss-Prot Function: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

Enzyme Numbers (IUBMB) for CTSE Gene

Gene Ontology (GO) - Molecular Function for CTSE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IDA 7789521
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with CTSE: view
genes like me logo Genes that share phenotypes with CTSE: view

Animal Models for CTSE Gene

MGI Knock Outs for CTSE:

miRNA for CTSE Gene

miRTarBase miRNAs that target CTSE

No data available for Transcription Factor Targeting and HOMER Transcription for CTSE Gene

Localization for CTSE Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSE Gene

Endosome. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTSE Gene COMPARTMENTS Subcellular localization image for CTSE gene
Compartment Confidence
endosome 5
lysosome 3
vacuole 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CTSE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IDA 7983070
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CTSE: view

Pathways for CTSE Gene

genes like me logo Genes that share pathways with CTSE: view

Pathways by source for CTSE Gene

2 Reactome pathways for CTSE Gene
1 KEGG pathway for CTSE Gene

Gene Ontology (GO) - Biological Process for CTSE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0007586 digestion TAS 2674141
GO:0016540 protein autoprocessing IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IDA 8765029
genes like me logo Genes that share ontologies with CTSE: view

Compounds for CTSE Gene

(6) Novoseek inferred chemical compound relationships for CTSE Gene

Compound -log(P) Hits PubMed IDs
pepsinogen 62.9 2
cysteine 34.6 4
mannose 29.4 2
proline 20.8 1
hydrogen 0 1
genes like me logo Genes that share compounds with CTSE: view

Transcripts for CTSE Gene

Unigene Clusters for CTSE Gene

Cathepsin E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTSE Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: -
SP2: - -
SP3:
SP4: - -

Relevant External Links for CTSE Gene

GeneLoc Exon Structure for
CTSE
ECgene alternative splicing isoforms for
CTSE

Expression for CTSE Gene

mRNA expression in normal human tissues for CTSE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTSE Gene

This gene is overexpressed in Stomach (41.1) and Lung (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CTSE Gene

SOURCE GeneReport for Unigene cluster for CTSE Gene Hs.644082

mRNA Expression by UniProt/SwissProt for CTSE Gene

P14091-CATE_HUMAN
Tissue specificity: Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.
genes like me logo Genes that share expressions with CTSE: view

Orthologs for CTSE Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTSE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTSE 35
  • 99.58 (n)
  • 100 (a)
CTSE 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTSE 35
  • 87.12 (n)
  • 88.89 (a)
CTSE 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctse 35
  • 83.33 (n)
  • 82.98 (a)
Ctse 16
Ctse 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTSE 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ctse 35
  • 84.39 (n)
  • 84.77 (a)
chicken
(Gallus gallus)
Aves CTSE 35
  • 69.94 (n)
  • 70.03 (a)
CTSE 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTSE 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctse 35
  • 67.2 (n)
  • 71.58 (a)
zebrafish
(Danio rerio)
Actinopterygii nots 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Bace 36
  • 44 (a)
ManyToMany
CG17134 36
  • 41 (a)
ManyToMany
CG17283 36
  • 31 (a)
ManyToMany
CG31661 36
  • 32 (a)
ManyToMany
CG31926 36
  • 32 (a)
ManyToMany
CG31928 36
  • 31 (a)
ManyToMany
CG33128 36
  • 38 (a)
ManyToMany
CG5860 36
  • 33 (a)
ManyToMany
CG5863 36
  • 39 (a)
ManyToMany
CG6508 36
  • 35 (a)
ManyToMany
pcl 36
  • 39 (a)
ManyToMany
CG17283 37
  • 40 (a)
CG5860 37
  • 36 (a)
CG17134 37
  • 42 (a)
CG6508 37
  • 40 (a)
CG13095 37
  • 45 (a)
pcl 37
  • 43 (a)
CG10104 37
  • 39 (a)
CG5863 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea asp-1 36
  • 33 (a)
ManyToMany
asp-10 36
  • 30 (a)
ManyToMany
asp-12 36
  • 32 (a)
ManyToMany
asp-13 36
  • 26 (a)
ManyToMany
asp-14 36
  • 19 (a)
ManyToMany
asp-15 36
  • 28 (a)
ManyToMany
asp-16 36
  • 31 (a)
ManyToMany
asp-17 36
  • 32 (a)
ManyToMany
asp-18 36
  • 31 (a)
ManyToMany
asp-19 36
  • 27 (a)
ManyToMany
asp-2 36
  • 20 (a)
ManyToMany
asp-5 36
  • 31 (a)
ManyToMany
asp-6 36
  • 31 (a)
ManyToMany
asp-7 36
  • 28 (a)
ManyToMany
asp-8 36
  • 23 (a)
ManyToMany
asp-9 36
  • 33 (a)
ManyToMany
asp-4 37
  • 45 (a)
C11D2.2 37
  • 34 (a)
Y39B6A.21 37
  • 35 (a)
asp-5 37
  • 33 (a)
F28A12.4 37
  • 30 (a)
F59D6.2 37
  • 29 (a)
Y39B6A.24 37
  • 31 (a)
asp-3 37
  • 42 (a)
F21F8.4 37
  • 32 (a)
Y39B6A.22 37
  • 29 (a)
C15C8.3 37
  • 32 (a)
F59D6.3 37
  • 32 (a)
asp-2 37
  • 34 (a)
Y39B6A.23 37
  • 33 (a)
asp-6 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP4 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10126 36
  • 43 (a)
ManyToMany
Species with no ortholog for CTSE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSE Gene

ENSEMBL:
Gene Tree for CTSE (if available)
TreeFam:
Gene Tree for CTSE (if available)

Paralogs for CTSE Gene

Paralogs for CTSE Gene

Selected SIMAP similar genes for CTSE Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CTSE: view

Variants for CTSE Gene

Sequence variations from dbSNP and Humsavar for CTSE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6503 - 206,012,363(-) TGTCA(C/T)CTTCA reference, missense
rs28402776 -- 206,019,743(-) TATAT(A/G)TAAGA intron-variant
rs28410805 -- 206,014,870(-) ATGAC(A/G)GCACT intron-variant
rs28463784 -- 206,018,677(-) TTACA(A/G)TTTTC intron-variant
rs28505779 -- 206,014,205(-) ACCCA(C/T)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTSE Gene

Variant ID Type Subtype PubMed ID
nsv873123 CNV Gain 21882294

Relevant External Links for CTSE Gene

HapMap Linkage Disequilibrium report
CTSE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSE Gene

Disorders for CTSE Gene

(1) MalaCards Diseases for CTSE Gene

Search for CTSE Gene in MalaCards »

(18) Novoseek inferred disease relationships for CTSE Gene

Disease -log(P) Hits PubMed IDs
adenocarcinoma gastric 32.4 2
chronic pancreatitis 20.9 5
gastric carcinoma 19.2 1
gastric cancer 17.2 5
dermatitis atopic 14.5 3
genes like me logo Genes that share disorders with CTSE: view

No data available for UniProtKB/Swiss-Prot for CTSE Gene

Publications for CTSE Gene

  1. Human gastric cathepsin E gene. Multiple transcripts result from alternative polyadenylation of the primary transcripts of a single gene locus at 1q31-q32. (PMID: 1370478) Azuma T. … Taggart R.T. (J. Biol. Chem. 1992) 3 4 23
  2. Structural evidence for two isozymic forms and the carbohydrate attachment site of human gastric cathepsin E. (PMID: 2334440) Athauda S.B.P. … Takahashi K. (Biochem. Biophys. Res. Commun. 1990) 3 4 23
  3. Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids. (PMID: 2369841) Couvreur J.M. … Taggart R.T. (Cytogenet. Cell Genet. 1990) 2 3 23
  4. Monomeric human cathepsin E. (PMID: 7789521) Fowler S.D. … Tatnell P.J. (FEBS Lett. 1995) 3 4 23
  5. Regulation of cathepsin E expression during human B cell differentiation in vitro. (PMID: 8765029) Sealy L. … Chain B. (Eur. J. Immunol. 1996) 3 4 23

Products for CTSE Gene

Sources for CTSE Gene

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