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CTSE Gene

protein-coding   GIFtS: 64
GCID: GC01P206319

Cathepsin E

  See CTSE-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cathepsin E1 2
EC 3.4.23.343 8
CATE2
Erythrocyte Membrane Aspartic Proteinase2
Slow-Moving Proteinase2
EC 3.4.238

External Ids:    HGNC: 25301   Entrez Gene: 15102   Ensembl: ENSG000001961887   OMIM: 1168905   UniProtKB: P140913   

Export aliases for CTSE gene to outside databases

Previous GC identifers: GC01U990032 GC01P202860 GC01P204484 GC01P177247


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTSE Gene:
The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer.
This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and
cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary
protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach.
It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric
cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative
polyadenylation signals and two transcript variants encoding different isoforms exist for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CTSE Gene:
CTSE (cathepsin E) is a protein-coding gene. Diseases associated with CTSE include pancreatic cancer. GO annotations related to this gene include aspartic-type endopeptidase activity and protein homodimerization activity. An important paralog of this gene is BACE1.

UniProtKB/Swiss-Prot: CATE_HUMAN, P14091
Function: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC
class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus,
and in neuronal degeneration and glial cell activation in the brain

Gene Wiki entry for CTSE (Cathepsin E) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTSE gene promoter:
         RelA   NF-kappaB   NF-E2 p45   Cdc5   Evi-1   Ik-2   NF-E2   Zic3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTSE promoter sequence
   Search Chromatin IP Primers for CTSE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTSE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

CTSE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSE gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P206319:  view genomic region     (about GC identifiers)

Start:
206,317,459 bp from pter      End:
206,332,104 bp from pter
Size:
14,646 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CATE_HUMAN, P14091 (See protein sequence)
Recommended Name: Cathepsin E precursor  
Size: 401 amino acids; 43312 Da
Subunit: Homodimer; disulfide-linked
2 PDB 3D structures from and Proteopedia for CTSE:
1LCG (3D)        1TZS (3D)    
Secondary accessions: Q5TZ01 Q5TZ02 Q9NY58 Q9UCE3 Q9UCE4
Alternative splicing: 3 isoforms:  P14091-3   P14091-1   P14091-2   

Explore the universe of human proteins at neXtProt for CTSE: NX_P14091

Explore proteomics data for CTSE at MOPED

Post-translational modifications: 

  • Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme
    contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In
    erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide1
  • Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-571
  • Glycosylation2 at Asn90
  • Selected DME Specific Peptides for CTSE (P14091) (see all 11)
     LPMFSVY  FTVIFDT  WILGDVF  GGVTPVFD 


    See CTSE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001901.1  NP_683865.1  

    ENSEMBL proteins: 
     ENSP00000350911   ENSP00000353350   ENSP00000354337   ENSP00000394607  
    Reactome Protein details: P14091

    CTSE Human Recombinant Protein Products:

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    Novus Biologicals CTSE Protein
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    Sino Biological Cell Lysate for CTSE
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    Cloud-Clone Corp. Proteins for CTSE

     
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    antibodies-online proteins for CTSE (15 products) 

     
    antibodies-online peptides for CTSE

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    antibodies-online kits for CTSE (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CTS: Cathepsins

    4 InterPro protein domains:
     IPR021109 Peptidase_aspartic_dom
     IPR001969 Aspartic_peptidase_AS
     IPR012848 Aspartic_peptidase_N
     IPR001461 Aspartic_peptidase

    Graphical View of Domain Structure for InterPro Entry P14091

    ProtoNet protein and cluster: P14091

    1 Blocks protein domain: IPB001461 Pepsin (A1) aspartic protease family signature

    UniProtKB/Swiss-Prot: CATE_HUMAN, P14091
    Similarity: Belongs to the peptidase A1 family


    Find genes that share domains with CTSE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATE_HUMAN, P14091
    Function: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC
    class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus,
    and in neuronal degeneration and glial cell activation in the brain
    Catalytic activity: Similar to cathepsin D, but slightly broader specificity
    Biophysicochemical properties: Kinetic parameters: KM=0.06 mM for hemoglobin; KM=0.13 mM for
    Pro-Pro-Thr-Ile-Phe-Phe(4-NO2)-Arg-Leu; KM=0.04 mM for Lys-Pro-Ile-Glu-Phe-Phe(4-NO2)-Arg-Leu;

         Genatlas biochemistry entry for CTSE:
    cathepsin E,aspartic proteinase

         Enzyme Numbers (IUBMB): EC 3.4.23.341 2 EC 3.4.232

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004190aspartic-type endopeptidase activity IDA7789521
    GO:0042803protein homodimerization activity IEA--
         
    Find genes that share ontologies with CTSE           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CTSE:
     Decreased POU5F1-GFP protein e 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ctse):
     hematopoietic system  homeostasis/metabolism  immune system  integument  reproductive system 

    Find genes that share phenotypes with CTSE           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CTSE: Ctsetm1Kjy Ctsetm1Bchn

       genOway: Develop your customized and physiologically relevant rodent model for CTSE

    miRNA
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    miRTarBase miRNAs that target CTSE:
    hsa-mir-25-3p (MIRT050230)

    Block miRNA regulation of human, mouse, rat CTSE using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CTSE:
    hsa-miR-3671 hsa-miR-3650 hsa-miR-607 hsa-miR-4306 hsa-miR-1270 hsa-miR-620 hsa-miR-185 hsa-miR-3919
    SwitchGear 3'UTR luciferase reporter plasmidCTSE 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CTSE

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): CTSE (NM_148964)
    Sino Biological Human cDNA Clone for CTSE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSE

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CATE_HUMAN, P14091: Endosome. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus,
    while the mature enzyme is localized to the endosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    lysosome3
    vacuole2
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome IDA7983070

    Find genes that share ontologies with CTSE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTSE About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2MHC class II antigen presentation
    MHC class II antigen presentation
    3Lysosome
    Lysosome


    Find genes that share SuperPaths with CTSE           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CTSE
        MHC class II antigen presentation


    1 Kegg Pathway  (Kegg details for CTSE):
        Lysosome

        Pathway & Disease-focused RT2 Profiler PCR Array including CTSE: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CTSE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTSE (P140912, 3 ENSP000003509114) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-63474 I2D: score=5 
    ENSG00000096155P463792, 3MINT-63474 I2D: score=5 
    ENSG00000227761P463792, 3MINT-63474 I2D: score=5 
    ENSG00000228760P463792, 3MINT-63474 I2D: score=5 
    ENSG00000229524P463792, 3MINT-63474 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007586digestion TAS2674141
    GO:0016540protein autoprocessing IEA--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II IDA8765029

    Find genes that share ontologies with CTSE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTSE (CATE)

    6 Novoseek inferred chemical compound relationships for CTSE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pepsinogen 62.9 2 10544016 (1), 10641336 (1)
    cysteine 34.6 4 9180269 (1), 8907186 (1), 17377742 (1), 15843176 (1)
    mannose 29.4 2 2105725 (1), 16633575 (1)
    proline 20.8 1 9365789 (1)
    hydrogen 0 1 15845357 (1)
    estrogen 0 1 10884806 (1)



    Find genes that share compounds with CTSE           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTSE gene (2 alternative transcripts): 
    NM_001910.3  NM_148964.2  

    Unigene Cluster for CTSE:

    Cathepsin E
    Hs.644082  [show with all ESTs]
    Unigene Representative Sequence: NM_001910
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358184(uc001hdu.3 uc001hdv.3 uc010prs.2) ENST00000360218
    ENST00000468617 ENST00000486757 ENST00000361052 ENST00000432969
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate CTSE:
    hsa-miR-3671 hsa-miR-3650 hsa-miR-607 hsa-miR-4306 hsa-miR-1270 hsa-miR-620 hsa-miR-185 hsa-miR-3919
    SwitchGear 3'UTR luciferase reporter plasmidCTSE 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CTSE (NM_148964)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSE
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    Additional mRNA sequence: 

    AJ250716.1 AJ250717.1 AK292057.1 AK298069.1 BC042537.1 J05036.1 

    2 DOTS entries:

    DT.212620  DT.100749003 

    Selected AceView cDNA sequences (see all 84):

    AU107385 BC042537 BM838098 AU100136 BM839715 BI819807 AA307644 AJ250717 
    BM769162 BM830486 BM836508 AU107383 BM830563 BM751704 J05036 NM_001910 
    BM837692 AJ250716 NM_148964 H61582 AW007303 BX092112 BX479645 BM769041 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CTSE    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
    SP1:                                -                                                   
    SP2:                                -                                   -               
    SP3:                                                                                    
    SP4:                    -           -                                                   


    ECgene alternative splicing isoforms for CTSE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTSE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CTSE Expression
    About this image


    CTSE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Epithelial Cells
             Corneocytes Stratified Epidermis
     
     Epidermis (Integumentary System)
             Corneocytes Stratified Epidermis
     
     NULL (Uncategorized)
             Endoderm progenitor-like cells
    CTSE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTSE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.644082

    UniProtKB/Swiss-Prot: CATE_HUMAN, P14091
    Tissue specificity: Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes,
    and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including CTSE: 
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    QuantiFast Probe-based Assays in human, mouse, rat CTSE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CTSE gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctse1 , 5 cathepsin E1, 5 83.33(n)1
    82.98(a)1
      1 (57.14 cM)5
    130341  NM_007799.31  NP_031825.21 
     1316383065 
    chicken
    (Gallus gallus)
    Aves CTSE1 cathepsin E 69.94(n)
    70.03(a)
      771791  XM_001235023.2  XP_001235024.2 
    lizard
    (Anolis carolinensis)
    Reptilia CTSE6
    cathepsin E
    71(a)
    1 ↔ 1
    GL343228.1(943991-955393)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ctse1 cathepsin E 67.2(n)
    71.58(a)
      100145572  NM_001126997.1  NP_001120469.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nots6
    nothepsin
    43(a)
    1 ↔ 1
    14(37891757-37901992) ENSDARG00000052792
    fruit fly
    (Drosophila melanogaster)
    Insecta CG130953 aspartic-type endopeptidase 45(a)
    (best of 8)
      29D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea asp-43 aspartyl protease 45(a)
    (best of 15)
      X(13254300-13256652)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PEP46
    Vacuolar aspartyl protease (proteinase A), require...
    39(a)
    1 → many
    XVI(259714-260931) YPL154C


    ENSEMBL Gene Tree for CTSE (if available)
    TreeFam Gene Tree for CTSE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTSE gene
    BACE12  CTSD2  PGA32  BACE22  NAPSA2  PGC2  PGA52  REN2  
    PGA42  
    8 SIMAP similar genes for CTSE using alignment to 3 protein entries:     CATE_HUMAN (see all proteins):
    PGA3    PGA4    DKFZp666J2410    PGA5    PGC    CTSD
    NAPSA    REN

    Find genes that share paralogs with CTSE           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTSE (see all 460)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs65031,2,,4
    C--1(-) TGTCAC/TCTTCA 4 T I P S mis13Minor allele frequency- T:0.03MN NA 50
    rs284027761,2
    --1(-) TATATA/GTAAGA 2 -- int10--------
    rs284108051,2
    C,F,H--1(-) ATGACA/GGCACT 2 -- int122Minor allele frequency- G:0.35NS EA NA WA CSA 2230
    rs285057791,2
    C,F,H--1(-) ACCCAC/TCCAGG 2 -- int114Minor allele frequency- T:0.08NS EA NA 1928
    rs285174531,2
    C,F--1(-) AATATA/GTTATG 2 -- int11Minor allele frequency- G:0.22NA 120
    rs285317941,2
    C,F,H--1(-) CCAAGG/AGTGGG 2 -- us2k114Minor allele frequency- A:0.20NS NA WA CSA 1366
    rs285480201,2
    C,F,H--1(-) CTACAC/ACCTAC 4 /N /T /P mis1 ese310Minor allele frequency- A:0.02NS NA WA 5608
    rs285506411,2
    C--1(-) GGTCCA/CTGGGG 2 -- int111Minor allele frequency- C:0.01NA WA CSA 137
    rs285722741,2
    C--1(-) TGCCAG/TGCCAT 3 Q H mis1 int1 ese32Minor allele frequency- T:0.00NA 4
    rs285897021,2
    C,F,H--1(-) TATTCG/AGCACC 2 -- int18Minor allele frequency- A:0.05NS NA WA 1012

    HapMap Linkage Disequilibrium report for CTSE (206317459 - 206332104 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CTSE:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873123CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTSE
    DNA2.0 Custom Variant and Variant Library Synthesis for CTSE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116890    OMIM disorders: --

    1 disease for CTSE:    
    About MalaCards
    pancreatic cancer


    Find genes that share disorders with CTSE           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CTSE gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma gastric 32.4 3 12531480 (1), 1370478 (1)
    chronic pancreatitis 20.9 5 11129230 (3), 8759606 (2)
    gastric carcinoma 19.2 1 11534800 (1)
    gastric cancer 17.2 6 8237369 (3), 8593471 (2)
    dermatitis atopic 14.5 3 12843568 (2), 15845357 (1)
    adenoma 11.7 9 12777211 (2), 19172291 (2), 8759606 (1)
    senile plaques 10.7 1 7697369 (1)
    adenocarcinoma 10.2 19 11129230 (9), 8759606 (4), 12777211 (2)
    metaplasia 3.81 3 11534800 (2)
    ischemia 0 1 11211863 (1)


    Export disorders for CTSE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTSE gene, integrated from 10 sources (see all 139):
    (articles sorted by number of sources associating them with CTSE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases. (PubMed id 2674141)1, 2, 3 Azuma T.... Taggart R.T. (J. Biol. Chem. 1989)
    2. Human gastric cathepsin E gene. Multiple transcripts result from alternative polyadenylation of the primary transcripts of a single gene locus at 1q31-q32. (PubMed id 1370478)1, 2, 9 Azuma T.... Taggart R.T. (J. Biol. Chem. 1992)
    3. Regulation of cathepsin E expression during human B cell differentiation in vitro. (PubMed id 8765029)1, 2, 9 Sealy L.... Chain B. (Eur. J. Immunol. 1996)
    4. Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids. (PubMed id 2369841)1, 3, 9 Couvreur J.M....Taggart R.T. (Cytogenet. Cell Genet. 1990)
    5. An alternatively spliced variant of cathepsin E in human gastric adenocarcinoma cells. (PubMed id 12531480)1, 2, 9 Tatnell P.J.... Kay J. (Biochim. Biophys. Acta 2003)
    6. Regulation of human and mouse procathepsin E gene expression. (PubMed id 11322887)1, 2, 9 Cook M.... Tatnell P.J. (Eur. J. Biochem. 2001)
    7. Monomeric human cathepsin E. (PubMed id 7789521)1, 2, 9 Fowler S.D.... Tatnell P.J. (FEBS Lett. 1995)
    8. Structural evidence for two isozymic forms and the carbohydrate attachment site of human gastric cathepsin E. (PubMed id 2334440)1, 2, 9 Athauda S.B.P.... Takahashi K. (Biochem. Biophys. Res. Commun. 1990)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Subcellular localization and targeting of cathepsin E. (PubMed id 7983070)1, 2 Finley E.M. and Kornfeld S. (J. Biol. Chem. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1510 HGNC: 2530 AceView: CTSE Ensembl:ENSG00000196188 euGenes: HUgn1510
    ECgene: CTSE Kegg: 1510 H-InvDB: CTSE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTSE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTSE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTSE gene:
    Search GeneIP for patents involving CTSE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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