Aliases for CTSD Gene
External Ids for CTSD Gene
Previous Symbols for CTSD Gene
This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]
GeneCards Summary for CTSD Gene
CTSD (Cathepsin D) is a Protein Coding gene. Diseases associated with CTSD include ceroid lipofuscinosis, neuronal, 10 and congenital neuronal ceroid lipofuscinosis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Degradation of the extracellular matrix. GO annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is BACE1.
UniProtKB/Swiss-Prot for CTSD Gene
Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease