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CTSD Gene

protein-coding GIFtS: 75

GC11M001730

cathepsin D
(Previous name: cathepsin D (lysosomal aspartyl protease) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CPSD)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CLN10 ^², ⁵
CPSD ^², ³, ⁵
EC 3.4.23.5 ^³
MGC2311 ^²

Descriptions
cathepsin D ^²
cathepsin D (lysosomal aspartyl protease) ^¹
lysosomal aspartyl peptidase ^²
lysosomal aspartyl protease ^²

External Ids
HGNC: 2529¹
Entrez Gene: 1509²
UniProtKB: P07339³
Ensembl: ENSG00000117984⁷

Search outside databases for aliases for CTSD gene

Previous GC identifers: GC11M001414 GC11M001847 GC11M001714 GC11M001738

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CTSD:

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and

light chains, both produced from a single protein precursor. This proteinase, which is a member of

the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A.

Transcription of this gene is initiated from several sites, including one which is a start site

for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of

several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq]

UniProtKB/Swiss-Prot: CATD_HUMAN, P07339

Function: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of

several diseases such as breast cancer and possibly Alzheimer disease

Gene Wiki entry for CTSD (Cathepsin_D)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CTSD gene

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

CTSD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M001730: (about GC identifiers)

Start:	1,730,561 bp from pter
End:	1,741,798 bp from pter
Size:	11,238 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CATD_HUMAN, P07339 (See protein sequence)

Recommended Name: Cathepsin D precursor

Size: 412 amino acids; 44552 Da

Subunit: Consists of a light chain and a heavy chain

Subcellular location: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome

fractions from stage I to stage IV

PDB structures from and Proteopedia :

1LYA (3D)

1LYB (3D)

1LYW (3D)

Secondary accessions: Q6IB57

REFSEQ proteins: NP_001900.1

ENSEMBL proteins:

ENSP00000236671 ENSP00000384947

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CTSD
	R&D Systems Recombinant & Natural Proteins for CTSD (Cathepsin D)
	Enzo Life Sciences proteins for CTSD
	Recombinant Proteins from Abcam (Cathepsin D, proCathepsin D)
	Human Recombinant Proteins from Abnova (CTSD)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005739	mitochondrion	IEA	--
GO:0005764	lysosome	NAS	--
GO:0042470	melanosome	IEA	--

About this table

Antibodies for CTSD:

	Invitrogen Antibodies for CTSD
	Millipore Mono- and Polyclonal Antibodies for the study of CTSD
	Sigma-Aldrich Antibody Arrays and Antibodies for CTSD
	R&D Systems Antibodies for CTSD (Cathepsin D)
	Cell Signaling Technology (CST) Antibodies for CTSD (Cathepsin D)
	Antibodies from Abcam (Cathepsin D, proCathepsin D), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CTSD)
	Novus Biologicals Antibodies for CTSD

Assays for CTSD:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P07339

ProtoNet protein and cluster: P07339

1 Blocks protein family: IPB001461 Pepsin (A1) aspartic protease family signature

UniProtKB/Swiss-Prot: CATD_HUMAN, P07339

Similarity: Belongs to the peptidase A1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CTSD)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CTSD)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001909

Applied Biosystems Silencer® siRNAs for CTSD

Sigma-Aldrich siRNA and siRNA Panels for CTSD

Sigma-Aldrich shRNA Panels and shRNA for CTSD

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CTSD
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001909
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001909
untagged cDNA clone in CMV expression vector: NM_001909

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001909

UniProtKB/Swiss-Prot: CATD_HUMAN, P07339

Function: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of

several diseases such as breast cancer and possibly Alzheimer disease

Catalytic activity: Specificity similar to, but narrower than, that of pepsin A. Does not cleave

the 4-Gln- -His-5 bond in B chain of insulin

Enzyme Number (IUBMB): EC 3.4.23.5

Genatlas biochemistry entry for CTSD:

cathepsin D,major retinal pigment epithelial aspartic proteinase,lysosomal,cleaving procaspase

3,ubiquitously expressed,involved in epidermal differentiation and major factor in the proteolysis

of opsin,potentially recruited during apoptosis,bound to ceramide for proteolytic activity,at most

a mild risk factor for sporadic Alzheimer's disease,not decreased in age related maculopathy

11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ctsd):

behavior/neurological	cellular	digestive/alimentary	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	life span-post-weaning/aging	nervous system
vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004190	aspartic-type endopeptidase activity	TAS	3927292
GO:0008233	peptidase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for CTSD (Your Favorite Gene powered by Ingenuity)

Ceramide Signaling
Huntington's Disease Signaling
Lysine Degradation
Aryl Hydrocarbon Receptor Signaling

GeneDecks CTSD for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CTSD

5/70 Interacting proteins for CTSD (ENSP00000236671³ P07339²) via UniProtKB, MINT, and/or STRING (see all 70 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APP	P05067²	STRING (score=.95) MINT-3974374 MINT-3974360
HBA1	P69905²	MINT-3974347
HBA2	P69905²	MINT-3974347
MARCH9	Q86YJ5²	MINT-4053134
M6PR	ENSP00000000412³	STRING (score=.958)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000045	autophagic vacuole formation	IEA	--
GO:0006508	proteolysis	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CTSD

Browse Small Molecules at Sigma-Aldrich

Compounds for CTSD available from Tocris Bioscience
10/55 Novoseek chemical compound relationships for CTSD gene (see all 55 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mannose 6-phosphate	85.86	40	12296771 (3), 18174267 (3), 1848227 (2), 8134116 (1) (see all 31)
progesterone	71.24	158	7906196 (4), 9238685 (4), 11062111 (3), 7915829 (3) (see all 99)
statine	58.86	2	10423175 (2)
3-(2,4-dinitroanilino)-3'-amino-n-methyldipropylamine	54.27	1	9278305 (1)
pepsinogen	41.40	5	2170024 (2), 1331083 (1), 8408210 (1)
estradiol	41.22	19	9271363 (3), 8920230 (2), 8137264 (1), 2222457 (1) (see all 15)
steroid	40.42	43	1633322 (2), 1688438 (2), 9673387 (2), 8487052 (2) (see all 32)
rennet	39.71	2	12464069 (2)
mannose	39.32	8	9694859 (2), 1848227 (1), 11300479 (1), 1660878 (1) (see all 7)
3-methyladenine	31.55	3	16850182 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CTSD)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CTSD)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001909

Sigma-Aldrich siRNA and siRNA Panels for CTSD

Sigma-Aldrich shRNA Panels and shRNA for CTSD

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001909

REFSEQ mRNAs for CTSD gene:

NM_001909.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001909

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001909
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001909
                                 untagged cDNA clone in CMV expression vector: NM_001909

Additional cDNA sequence:

AK130178.1 BC001574.1 BC016320.2 BC036199.1 BT006910.1 BT020155.1 CR456947.1 CR597228.1

CR609839.1 CR612133.1 CR613410.1 CR623521.1 M11233.1 X05344.1

24/45 DOTS entries (see all 45 ):

DT.450575 DT.95090842 DT.97806869 DT.100889534 DT.100889548 DT.100889543 DT.95231629 DT.100889540

DT.95231802 DT.100889514 DT.92469315 DT.100039640 DT.100889517 DT.92042237 DT.108744 DT.91752367

DT.95317688 DT.100889520 DT.120699379 DT.95231735 DT.120699376 DT.91746087 DT.100889528 DT.95120527

24/1563 AceView cDNA sequences (see all 1563 ):

BM708319 BM694848 BF528084 BU191048 BQ672240 BC016320 CN482387 BX337990

BM759138 BG035861 AJ346214 CA489132 T29113 R84987 BM763542 BX476363

BU501886 BP355905 BM821219 AW732268 BG287247 BE907772 BU542022 F24168

highest scoring ESTs for CTSD:

AA018954 AA074710 AA410697 AA433879 AI751896 AU119847 AW067770 AW403966 AW498958 AW630435

Unigene Clusters for CTSD:

Cathepsin D

Hs.121575 [show with all ESTs], Hs.654447 [show with all ESTs]

Unigene Representative Sequences: AK022293, NM_001909

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CTSD (see all 6 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10	^	11a	·	11b
SP1:							-		-																		-						-				-
SP2:							-		-				-
SP3:							-		-						-
SP4:																																					-
SP5:																																	-

About this scheme

ECgene alternative splicing isoforms for CTSD

2 Ensembl transcripts including schematic representations:

ENST00000236671 ENST00000407742

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CTSD expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CTSD

¹ / ² / ³

8 probe-sets matching CTSD gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
239_at²^{, 3}	U95-A	1	1.00	1.00	0.67	1.12	M63138	0.20	1.00	0.72	1
88716_at²^{, 3}	U95-E	3	1.00	0.48	0.88	0.88	AI927079	0.60	0.62	0.61	1
200766_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001909	0.60	1.00	0.82	1
227886_at²^{, 3}	U133-B	2	1.00	0.50	--	--	AU147615	0.60	1.00	0.82	1
227863_at²^{, 3}	U133-B	3	1.00	0.42	--	--	AV706254	0.40	0.67	0.55	1
200766_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227886_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
227863_at²	U133Plus2	3	1.00	0.42	--	--	--	--	--	--	--

GeneDecks CTSD for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.121575 Hs.654447
Expression variation in blood from EXPOLDB for CTSD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CTSD gene from 5/23 species (see all 23 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CTSD¹	--	cathepsin D	87.72(n) 88.54(a)	483662 NM_001025621.1 NP_001020792.1
cow (Bos taurus)	CTSD¹	--	cathepsin D	85.69(n) 83.9(a)	282883 XM_609913.3 XP_609913.3
rat (Rattus norvegicus)	Ctsd¹	--	cathepsin D	81.33(n) 83.29(a)	171293 NM_134334.2 NP_599161.2
mouse (Mus musculus)	Ctsd^{1, 5}	7⁵	cathepsin D^{1, 5}	80.44(n)¹ 81.91(a)¹	13033¹ NM_009983.2¹ NP_034113.1¹ AK089294⁵ AK093885⁵ (see all 87)
chicken (Gallus gallus)	CTSD¹	--	cathepsin D	71.72(n) 69.95(a)	396090 NM_205177.1 NP_990508.1

About this table Species with no ortholog for CTSD

ENSEMBL Gene Tree for CTSD

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CTSD gene

NAPSB² BACE1² BACE2² NAPSA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: CATD_HUMAN, P07339

Polymorphism: The Val-58 allele is significantly overrepresented in demented patients (11.8%)

compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold

increased risk for developing AD than non-carriers

10/73 NCBI SNPs in CTSD are shown (see all 73 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 31)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs698450^1,2	A,C,F	1730872(-)	`CCCCTC/TTGCCC`	1	--	ut3¹ ese³		1	MN	184
	rs17571^1,2	C,F,H	1739170(-)	`CCAGGC/TGGTGC`	1	A/V	mis¹ ese³		10	MN EU EA WA	1060
	rs8839^1,2	A,F	1730712(-)	`GAGCCA/CGTCCC`	1	--	ut3¹ ese³		1	MN	184
	rs12214^1,2	A,F	1731242(-)	`GGCCCA/GGCGGC`	1	--	ut3¹ ese³		2	MN	372
	rs1051143^1,2	F	1730616(-)	`TTGGGC/GGGCTG`	1	--	ut3¹ ese³		1	MN	184
--	rs698452^1,2	F	1730751(-)	`AACCCA/CCCTTG`	1	--	ut3¹		1	MN	184
--	rs2230067^1,2	F	1737443(-)	`CAGGCC/TCAGTA`	1	A/A	syn¹		1	MN	52
	rs1320294^1,2	A	1735249(-)	`AAGTTC/TGATGG`	1	F/F	syn¹ ese³		1	MN	184
	rs1317356^1,2	A,C,F,H	1735714(-)	`AGGCTG/ATGTCT`	1	--	int¹		6	EU EA WA NA	594
	rs2292963^1,2	C,F,H	1732908(-)	`ATTCAC/TCCTCT`	1	--	int¹		5	EA EU WA	1906

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HapMap Linkage Disequilibrium images for CTSD (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 116840 disorders: 610127

UniProtKB/Swiss-Prot: CATD_HUMAN, P07339

Defects in CTSD are the cause of neuronal ceroid lipofuscinosis 10 (CLN10) [MIM:610127];

also known as neuronal ceroid lipofuscinosis due to cathepsin D deficiency. The neuronal ceroid

lipofuscinosis are a group of progressive neurodegenerative diseases in children and in adults,

characterized by visual and mental decline, motor disturbance, epilepsy and behavioral changes

10/93 Novoseek disease relationships for CTSD gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	79.45	418	8261461 (7), 9527695 (5), 8443752 (5), 9765021 (5) (see all 99)
breast carcinoma	74.06	68	1332483 (3), 9701723 (3), 8410496 (3), 11753972 (3) (see all 46)
metastasis	64.47	150	16033070 (6), 10562684 (5), 12140763 (4), 18433155 (4) (see all 96)
carcinoma ductal	63.07	16	8816882 (2), 9683294 (2), 7906196 (1), 17996735 (1) (see all 13)
tumors	61.97	425	1332483 (5), 8816882 (5), 9179261 (5), 8697388 (4) (see all 99)
invasive ductal breast carcinoma	58.66	7	17908479 (2), 8291222 (1), 8225242 (1), 10503271 (1) (see all 6)
neuronal ceroid lipofuscinoses	55.58	6	18091563 (2), 17495518 (1), 16670177 (1), 15837574 (1)
carcinoma	54.81	66	16033070 (4), 16244588 (3), 7540754 (3), 11474252 (2) (see all 42)
alzheimers disease	53.18	68	1795881 (3), 15003956 (3), 10218883 (2), 7649217 (2) (see all 45)
ductal breast carcinoma	52.17	3	11940423 (1), 18254778 (1), 10610231 (1)

About this table

GeneTests: CTSD

Neuronal Ceroid-Lipofuscinoses

Human Gene Mutation Database: CTSD
Genetic Association Database: CTSD
Human Genome Epidemiology Navigator: CTSD (29 documents)
Tumor Gene Database: CTSD
Breast Cancer Gene Database: CTSD

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1010 PubMed articles for CTSD gene (see all 1010 ):

Cloning and sequence analysis of cDNA for human cathepsin D. (PubMed id 3927292)^{2, 3, 4} Faust P.L.... Chirgwin J.M. (1985)
Cathepsin D deficiency is associated with a human neurodegenerative disorder. (PubMed id 16685649)^{1, 3, 4} Steinfeld R.... Gartner J. (2006)
Association between cathepsin D polymorphism and Alzheimer's disease in a Chinese Han population. (PubMed id 15211064)^{1, 3, 6} Li X.Q....Zhang J.W. (2004)
Two crystal structures for cathepsin D: the lysosomal targeting signal and active site. (PubMed id 8467789)^{1, 3, 4} Metcalf P. and Fusek M. (1993)
Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease: a HuGE gene-disease association review. (PubMed id 15003956)^{1, 3, 6} Ntais C....Ioannidis J.P. (2004)
Cathepsin D polymorphism in Italian sporadic and familial Alzheimer's disease. (PubMed id 12147324)^{1, 3, 6} Bagnoli S....Sorbi S. (2002)
Non-replication of association between cathepsin D genotype and late onset Alzheimer disease. (PubMed id 11304834)^{1, 3, 6} Menzer G....Finckh U. (2001)
[The C224T polymorphism in the cathepsin D gene is not associated with sporadic Alzheimer's disease in Chinese] (PubMed id 15843343)^{1, 3, 6} Sun Y....Li T. (2005)
The cathepsin D gene exon 2 (C224T) polymorphism and sporadic Alzheimer's disease in European populations. (PubMed id 16127101)^{1, 3, 6} Capurso C....Panza F. (2005)
Contribution of apolipoprotein E and cathepsin D genotypes to the familial aggregation of Alzheimer's disease. (PubMed id 15211070)^{1, 3, 6} Heun R....Jessen F. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1509	HGNC: 2529	AceView: CTSD	Ensembl:ENSG00000117984	euGenes: HUgn1509
ECgene: CTSD	H-InvDB: CTSD

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CTSD	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CTSD
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CTSD:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CTSD-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CTSD		Antibodies for CTSD
	Explore super-pooled esiRNAs		Proteins for CTSD
	Lentivirus-delivered shRNAs for CTSD		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CTSD)
	Antibodies (CTSD)
	Chimera RNAi (CTSD)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CTSD (Cathepsin D)

	Recombinant Proteins (Cathepsin D, proCathepsin D)
	Antibodies (Cathepsin D, proCathepsin D)

Search OriGene for CTSD

Tocris compounds for CTSD

	Drugs/Proteins for CTSD
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CTSD

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CTSD Gene at Home site.
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CTSD Gene

protein-coding GIFtS: 75

Aliases &
Descriptions
for CTSD

Summaries
for CTSD

Genomic Location
for CTSD

Proteins
for CTSD

Protein Domains/
Families
for CTSD

Gene Function
for CTSD

Pathways & Interactions
for CTSD

Drugs & Compounds
for CTSD

Transcripts
for CTSD

Expression
for CTSD

Orthologs
for CTSD

Paralogs
for CTSD

SNPs/Variants
for CTSD

Disorders & Mutations
for CTSD

Medical News
for CTSD

Publications
for CTSD

Search for CTSD

Genome Databases showing CTSD

Other Databases showing CTSD

Specialized Databases showing CTSD

Licensable Technologies
for CTSD

Services
for CTSD

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CTSD Gene

protein-coding GIFtS: 75

Aliases & Descriptionsfor CTSD

Summariesfor CTSD

Genomic Locationfor CTSD

Proteinsfor CTSD

Protein Domains/Familiesfor CTSD

Gene Functionfor CTSD

Pathways & Interactionsfor CTSD

Drugs & Compoundsfor CTSD

Transcriptsfor CTSD

Expression for CTSD

Orthologsfor CTSD

Paralogsfor CTSD

SNPs/Variantsfor CTSD

Disorders & Mutationsfor CTSD

Medical Newsfor CTSD

Publicationsfor CTSD

Search for CTSD

Genome Databases showing CTSD

Other Databases showing CTSD

Specialized Databases showing CTSD

Licensable Technologiesfor CTSD

Servicesfor CTSD

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CTSD

Summaries
for CTSD

Genomic Location
for CTSD

Proteins
for CTSD

Protein Domains/
Families
for CTSD

Gene Function
for CTSD

Pathways & Interactions
for CTSD

Drugs & Compounds
for CTSD

Transcripts
for CTSD

Expression
for CTSD

Orthologs
for CTSD

Paralogs
for CTSD

SNPs/Variants
for CTSD

Disorders & Mutations
for CTSD

Medical News
for CTSD

Publications
for CTSD

Licensable Technologies
for CTSD

Services
for CTSD