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CTSB Gene

protein-coding   GIFtS: 74
GCID: GC08M011700

Cathepsin B

  See CTSB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cathepsin B1 2     EC 3.4.22.13 8
CPSB2 3 5     Amyloid Precursor Protein Secretase2
Cathepsin B12 3     Cysteine Protease2
APPS2 3     EC 3.4.228
APP Secretase2 3     

External Ids:    HGNC: 25271   Entrez Gene: 15082   Ensembl: ENSG000001647337   OMIM: 1168105   UniProtKB: P078583   

Export aliases for CTSB gene to outside databases

Previous GC identifers: GC08M011764 GC08M011571 GC08M011739 GC08M011737 GC08M010630


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTSB Gene:
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy
and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein
secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete
proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common
cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been
associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same
protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CTSB Gene:
CTSB (cathepsin B) is a protein-coding gene. Diseases associated with CTSB include occlusion of gallbladder, and keratolytic winter erythema. GO annotations related to this gene include cysteine-type endopeptidase activity and cysteine-type peptidase activity. An important paralog of this gene is TINAG.

UniProtKB/Swiss-Prot: CATB_HUMAN, P07858
Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins.
Has also been implicated in tumor invasion and metastasis

Gene Wiki entry for CTSB (Cathepsin B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_077531.5  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTSB gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): CTSB promoter sequence
   Search Chromatin IP Primers for CTSB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTSB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8p23.1   HGNC cytogenetic band: 8p23.1

CTSB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTSB gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M011700:  view genomic region     (about GC identifiers)

Start:
11,700,033 bp from pter      End:
11,726,957 bp from pter
Size:
26,925 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CATB_HUMAN, P07858 (See protein sequence)
Recommended Name: Cathepsin B precursor  
Size: 339 amino acids; 37822 Da
Subunit: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2
Selected PDB 3D structures from and Proteopedia for CTSB (see all 11):
1CSB (3D)        1GMY (3D)        1HUC (3D)        1PBH (3D)        2IPP (3D)        2PBH (3D)    
Secondary accessions: B3KQR5 B3KRR5 Q503A6 Q96D87

Explore the universe of human proteins at neXtProt for CTSB: NX_P07858

Explore proteomics data for CTSB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys223, Lys237
  • Glycosylation2 at Asn192
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CTSB (P07858) (see all 11)
     CGSCWAF  GGHAIRI  PLSDELVN  PSFHPLSD 


    See CTSB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001899.1  NP_680090.1  NP_680091.1  NP_680092.1  NP_680093.1  

    ENSEMBL proteins: 
     ENSP00000473301   ENSP00000345672   ENSP00000435105   ENSP00000433215   ENSP00000409917  
     ENSP00000436456   ENSP00000342070   ENSP00000432244   ENSP00000434217   ENSP00000436159  
     ENSP00000433995   ENSP00000435074   ENSP00000436627   ENSP00000434725   ENSP00000436122  
     ENSP00000431518   ENSP00000435650   ENSP00000436074   ENSP00000435886   ENSP00000431143  
     ENSP00000435260   ENSP00000433379   ENSP00000433929   ENSP00000432077   ENSP00000432408  
     ENSP00000415889   ENSP00000411254  
    Reactome Protein details: P07858

    CTSB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CTSB (Cathepsin B)
    Enzo Life Sciences proteins for CTSB
    OriGene Purified Proteins for CTSB
    OriGene Protein Over-expression Lysate for CTSB
    OriGene MassSpec for CTSB
    OriGene Custom Protein Services for CTSB
    GenScript Custom Purified and Recombinant Proteins Services for CTSB
    Novus Biologicals CTSB Proteins
    Novus Biologicals CTSB Lysates
    Sino Biological Recombinant Protein for CTSB
    Sino Biological Cell Lysate for CTSB
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTSB

     
    Search eBioscience for Proteins for CTSB 

    CTSB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CTSB
    R&D Systems Antibodies for CTSB (Cathepsin B)
    Cell Signaling Technology (CST) Antibodies for CTSB 
    OriGene Antibodies for CTSB
    OriGene Custom Antibody Services for CTSB
    Novus Biologicals CTSB Antibodies
    Abcam antibodies for CTSB
    Cloud-Clone Corp. Antibodies for CTSB
    ThermoFisher Antibodies for CTSB
    LSBio Antibodies in human, mouse, rat for CTSB

    CTSB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CTSB
    R&D Systems ELISAs for CTSB (Cathepsin B)         (see all)
    GenScript CTSB-Activity-based Protease?src=genec Assay for Compound Screening
    Enzo Life Sciences assays for CTSB
    Cloud-Clone Corp. ELISAs for CTSB
    Cloud-Clone Corp. CLIAs for CTSB
    Search eBioscience for ELISAs for CTSB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CTS: Cathepsins

    Selected InterPro protein domains (see all 6):
     IPR013128 Peptidase_C1A
     IPR025661 Pept_asp_AS
     IPR000169 Pept_cys_AS
     IPR012599 Propeptide_C1A
     IPR025660 Pept_his_AS

    Graphical View of Domain Structure for InterPro Entry P07858

    ProtoNet protein and cluster: P07858

    2 Blocks protein domains:
    IPB000668 Papain cysteine protease (C1) family signature
    IPB012599 Peptidase C1


    UniProtKB/Swiss-Prot: CATB_HUMAN, P07858
    Similarity: Belongs to the peptidase C1 family


    Find genes that share domains with CTSB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CATB_HUMAN, P07858
    Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins.
    Has also been implicated in tumor invasion and metastasis
    Catalytic activity: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves
    -Arg-Arg- -Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an
    endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides

         Genatlas biochemistry entry for CTSB:
    cathepsin B,lysosomal cysteine proteinase,ubiquitously expressed,?same as APP secretase,?prorenin-processing
    enzyme,papain superfamily,involved in matrix degradation during endochondral ossification,contributing to both
    local invasion at the early stage and remote metastasis in colorectal cancer

         Enzyme Numbers (IUBMB): EC 3.4.22.11 2 EC 3.4.222

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004197cysteine-type endopeptidase activity IDA--
    GO:0005515protein binding IPI16364318
    GO:0005518collagen binding IDA--
    GO:0008233peptidase activity IDA7890620
    GO:0008234cysteine-type peptidase activity IDA8811434
         
    Find genes that share ontologies with CTSB           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CTSB:
     Decreased homologous recombina  Increased cell death HMECs cel  Synthetic lethal with Ras  Synthetic lethal with imatinib 

         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ctsb):
     behavior/neurological  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     normal  other  renal/urinary system  tumorigenesis 

    Find genes that share phenotypes with CTSB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ctsbtm1Jde for CTSB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTSB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTSB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTSB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTSB

    miRNA
    Products:
        
    miRTarBase miRNAs that target CTSB:
    hsa-mir-27b-3p (MIRT046187), hsa-mir-92a-3p (MIRT049702)

    Block miRNA regulation of human, mouse, rat CTSB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTSB (see all 17):
    hsa-miR-3685 hsa-miR-320a hsa-miR-1271 hsa-miR-320d hsa-miR-486-3p hsa-miR-431 hsa-miR-7 hsa-miR-339-5p
    SwitchGear 3'UTR luciferase reporter plasmidCTSB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CTSB
    Predesigned siRNA for gene silencing in human, mouse, rat CTSB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CTSB

    Clone
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    OriGene clones in human, mouse for CTSB (see all 29)
    OriGene ORF clones in mouse, rat for CTSB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): CTSB (NM_001908)
    Sino Biological Human cDNA Clone for CTSB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSB
    Addgene plasmids for CTSB 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CTSB
    Browse ESI BIO Cell Lines and PureStem Progenitors for CTSB 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSB

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12282) for CTSB 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CATB_HUMAN, P07858: Lysosome. Melanosome. Secreted, extracellular space (By similarity). Note=Identified by mass
    spectrometry in melanosome fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    vacuole5
    endosome4
    nucleus4
    extracellular3
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    golgi apparatus2
    mitochondrion2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ISS--
    GO:0005622intracellular TAS1645961
    GO:0005730nucleolus IDA--
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with CTSB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTSB About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    2Collagen biosynthesis and modifying enzymes
    Collagen formation0.75
    Assembly of collagen fibrils and other multimeric structures0.62
    3Immune response Bacterial infections in normal airways
    Bacterial infections in CF airways0.78
    4Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    5Allograft rejection
    Antigen processing and presentation0.36


    Find genes that share SuperPaths with CTSB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CTSB
        A-beta Plaque Formation & APP Metabolism


    2 Cell Signaling Technology (CST) Pathways for CTSB
        Apoptosis and Autophagy
    Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for CTSB
        Bacterial infections in CF airways


    4 Reactome Pathways for CTSB
        Assembly of collagen fibrils and other multimeric structures
    Trafficking and processing of endosomal TLR
    Collagen degradation
    MHC class II antigen presentation


    2 Kegg Pathways  (Kegg details for CTSB):
        Lysosome
    Antigen processing and presentation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTSB (see all 9): 
              Antiviral Response in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CTSB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTSB (P078581, 2, 3 ENSP000003420704) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-63430 I2D: score=5 
    ENSG00000096155P463792, 3MINT-63430 I2D: score=5 
    ENSG00000227761P463792, 3MINT-63430 I2D: score=5 
    ENSG00000228760P463792, 3MINT-63430 I2D: score=5 
    ENSG00000229524P463792, 3MINT-63430 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0006508proteolysis IDA7890620
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030574collagen catabolic process TAS--

    Find genes that share ontologies with CTSB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CTSB
    Selected ApexBio Compounds for CTSB (see all 12)     About this table
    CompoundAction CAS #
    CA 074Inhibitor of cathepsin B[134448-10-5]
    CA-074 Meirreversible inhibitor of intracellular cathepsin B[147859-80-1]
    CalpeptinPotent cathepsin L inhibitor[117591-20-5]
    Cathepsin G Inhibitor Ipotent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G[429676-93-7]
    Cathepsin S inhibitorA slow, tight-binding reversible inhibitor of recombinant cathepsin S[1373215-15-6]
    E 64dthiol protease inhibitor1[88321-09-9]
    E-64Irriversible cysteine protease inhibitor[66701-25-5]
    E-64-cinhibits cathepsin B, cathepsin H, and cathepsin L[76684-89-4]
    L 006235Potent, reversible cathepsin K inhibitor[294623-49-7]
    MDL 28170Potent, selective inhibitor of calpain and cathepsin B[88191-84-8]

    Browse Tocris compounds for CTSB (CATB)

    Selected DrugBank Compounds for CTSB (see all 14)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-Pyridinethiol-- --target--17139284 17016423 10592235
    3-Amino-4-Oxybenzyl-2-Butanone-- --target--17139284 17016423 10592235
    Diphenylacetic Acid-- --target--17139284 17016423 10592235
    2-Aminoethanimidic Acid-- --target--17139284 17016423
    3-Methylphenylalanine-- --target--17139284 17016423
    BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE-- --target--10592235
    METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE-- --target--10592235
    N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline-- 134448-10-5target--10592235
    N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE-- --target--10592235
    N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for CTSB gene (see all 125)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 90.8 376 7944391 (4), 9569125 (3), 7731994 (2), 8762055 (2) (see all 99)
    ca 074 89.2 16 9546050 (2), 10739956 (1), 11258881 (1), 10380357 (1) (see all 12)
    actinidin 77.4 11 8654398 (3), 7887904 (2), 7575465 (1), 8718861 (1) (see all 8)
    e 64d 75.8 7 16874052 (1), 16339296 (1), 17097791 (1), 12893746 (1) (see all 6)
    7-amino-4-trifluoromethylcoumarin 75.2 2 1355496 (1), 1356148 (1)
    poststatin 74.8 4 8931723 (2), 8931724 (1), 8931725 (1)
    z-arg-arg-nhmec 70.1 1 10900131 (1)
    leupeptin 68.7 16 12220505 (1), 8762057 (1), 10075843 (1), 10501085 (1) (see all 13)
    trypsinogen 67.5 47 12102727 (4), 19900452 (3), 8286198 (3), 7485384 (3) (see all 20)
    pheg 61.5 1 16029017 (1)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTSB gene (5 alternative transcripts): 
    NM_001908.3  NM_147780.2  NM_147781.2  NM_147782.2  NM_147783.2  

    Unigene Cluster for CTSB:

    Cathepsin B
    Hs.520898  [show with all ESTs]
    Unigene Representative Sequence: NM_147780
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 35):
    ENST00000526481 ENST00000353047(uc003wuu.3) ENST00000420692 ENST00000530640
    ENST00000531089 ENST00000453527 ENST00000531551 ENST00000345125 ENST00000533455
    ENST00000534510 ENST00000530624 ENST00000532409 ENST00000530290 ENST00000533110
    ENST00000534636 ENST00000533572 ENST00000530296 ENST00000525076
    miRNA
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    Block miRNA regulation of human, mouse, rat CTSB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTSB (see all 17):
    hsa-miR-3685 hsa-miR-320a hsa-miR-1271 hsa-miR-320d hsa-miR-486-3p hsa-miR-431 hsa-miR-7 hsa-miR-339-5p
    SwitchGear 3'UTR luciferase reporter plasmidCTSB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CTSB
    Clone
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    OriGene ORF clones in mouse, rat for CTSB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): CTSB (NM_001908)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTSB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTSB
    Addgene plasmids for CTSB 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CTSB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTSB
      QuantiTect SYBR Green Assays in human, mouse, rat CTSB
      QuantiFast Probe-based Assays in human, mouse, rat CTSB
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12282) for CTSB 

    Additional mRNA sequence: 

    AK075393.1 AK092070.1 AK097384.1 AK098296.1 AK127308.1 AK130184.1 AK290239.1 AK296845.1 
    AK297687.1 BC010240.1 BC095408.1 BX647765.1 BX647952.1 L16510.1 L38712.1 M13230.1 
    M14221.1 Y18460.1 

    Selected DOTS entries (see all 103):

    DT.100850425  DT.100686825  DT.100849772  DT.100059728  DT.95316962  DT.100714463  DT.100686806  DT.92061400 
    DT.120646724  DT.95258060  DT.120646898  DT.95258117  DT.100686820  DT.100686850  DT.120646761  DT.100686824 
    DT.120646609  DT.100686868  DT.100686835  DT.100641889  DT.120646644  DT.95258033  DT.100686838  DT.120646856 

    Selected AceView cDNA sequences (see all 1176):

    BX438066 BG252355 CB164331 BF592126 CR612536 CB215576 CR623525 BQ233626 
    BI869520 AA350183 AV656950 BM849260 CR592977 BF725741 BE166171 CR609540 
    BE744162 BM928618 CR596339 BQ441654 BU151673 BM049672 BI060048 CR603066 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CTSB (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
    SP1:                    -     -     -     -     -     -                                                     -     -                 -     -                     
    SP2:                    -     -     -     -     -           -                                               -     -                 -     -                     
    SP3:                    -     -     -     -     -     -     -                                               -     -                 -     -                     
    SP4:                                                                                                                                                            
    SP5:                                            -     -     -                                               -     -                                             

    ExUns: 14b ^ 15 ^ 16a · 16b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for CTSB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CTSB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGTGAGCC
    CTSB Expression
    About this image


    CTSB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Monocytes Peripheral Blood
     
     Placenta (Extraembryonic Tissues)
             Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Brain (Nervous System)
             Cerebral Cortex
    CTSB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTSB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520898
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTSB (see all 9): 
              Antiviral Response in human mouse rat
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CTSB
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTSB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CTSB gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctsb1 , 5 cathepsin B1, 5 80.04(n)1
    78.76(a)1
      14 (33.24 cM)5
    130301  NM_007798.31  NP_031824.11 
     631224625 
    chicken
    (Gallus gallus)
    Aves CTSB1 cathepsin B 75.71(n)
    76.4(a)
      396329  XM_004935898.1  XP_004935955.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTSB6
    cathepsin B
    70(a)
    1 ↔ 1
    GL343309.1(177011-194545)
    African clawed frog
    (Xenopus laevis)
    Amphibia cg10992-prov2 hypothetical protein MGC52983 76.02(n)    BC046667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044517.12   -- 76.33(n)   394030  BC044517.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG109923
    CtsB11
    cathepsin B3
    Cathepsin B11
    58(a)3
    59.9(n)1
    59.69(a)1
      12C23
    323411  NM_132692.31  NP_572920.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F57F5.13 cysteine protease 51(a)
    (best of 7)
      V(12005606-12006629)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G023051 AT1G02305 55.36(n)
    53.15(a)
      839538  NM_100111.3  NP_563648.1 
    rice
    (Oryza sativa)
    Liliopsida AK064820.12   -- 78.02(n)    AK064820.1 


    ENSEMBL Gene Tree for CTSB (if available)
    TreeFam Gene Tree for CTSB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTSB gene
    TINAG2  TINAGL12  
    3 SIMAP similar genes for CTSB using alignment to 18 protein entries:     CATB_HUMAN (see all proteins):
    DKFZp686N0152    CTSS    DKFZp686B24257

    Find genes that share paralogs with CTSB           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CTSB
    PGOHUM00000245227 PGOHUM00000245492


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTSB (see all 1259)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447253581,2
    C--10654001(+) GCGGAG/-GTTGC 5 -- int11Minor allele frequency- -:0.00NA 2
    rs286133131,2
    C--10658081(+) AAAAAG/AAAGGC 5 -- us2k1 trp32Minor allele frequency- A:0.00WA CSA 3
    rs1494457491,2
    C--11705380(+) GGAGA-/AGCCCCAG
    CTGGGCGAGGC
    AGACC
    5 -- int10--------
    rs575096231,2
    C--11706970(+) TCAAC-/GATTTG 5 -- int11Minor allele frequency- G:0.00NA 2
    rs1999560361,2
    C--11706970(+) TCAACA/GATTTG 5 -- int10--------
    rs2012905281,2
    C--11707088(+) GTGTGG/TTTTTT 5 -- int10--------
    rs26454181,2
    C,F,A,H--11707951(-) TCTTTT/CTTTTT 5 -- int1 trp33Minor allele frequency- C:0.33NA WA 6
    rs345042341,2
    C,F--11711114(+) AACTCT/-TAAGG 5 -- int13Minor allele frequency- -:0.50NA CSA 6
    rs3715652271,2
    C--11713534(+) TGCCT-/AAAAAAT 5 -- int10--------
    rs613448671,2
    C--11714365(+) TTAAG-/AAAAAA 5 -- int10--------

    HapMap Linkage Disequilibrium report for CTSB (11700033 - 11726957 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CTSB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668269CNV Deletion23128226
    esv34042CNV Loss18971310
    nsv890369CNV Loss21882294
    nsv890368CNV Loss21882294
    nsv890362CNV Loss21882294
    nsv890361CNV Gain21882294
    nsv890366CNV Gain21882294
    nsv890367CNV Gain21882294
    nsv890365CNV Gain21882294
    nsv516685CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): CTSB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTSB
    DNA2.0 Custom Variant and Variant Library Synthesis for CTSB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116810    OMIM disorders: --

    14 diseases for CTSB:    
    About MalaCards
    occlusion of gallbladder    keratolytic winter erythema    tropical calcific pancreatitis    benign meningioma
    adenocarcinoma    gingival overgrowth    hereditary pancreatitis    mucolipidosis ii
    pancreatitis    amyloidosis, secondary    keratoconus    dementia
    meningioma    alzheimer's disease

    5 diseases from the University of Copenhagen DISEASES database for CTSB:
    Pancreatitis     Alzheimer's disease     Carcinoma     Arthritis
    Occlusion of gallbladder

    Find genes that share disorders with CTSB           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CTSB gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 56.5 392 9524062 (7), 9499362 (6), 11147599 (6), 9770500 (6) (see all 99)
    osteoclastoma 54.7 3 8467955 (2), 1540624 (1)
    metastasis 54.3 104 7677635 (3), 8330299 (3), 18296264 (3), 11147599 (3) (see all 79)
    alzheimers disease 49.6 26 1795881 (3), 7674807 (2), 11033346 (1), 11880515 (1) (see all 21)
    senile plaques 49.5 9 1692625 (2), 1795881 (1), 7592716 (1), 1584965 (1) (see all 8)
    cancer 48.8 131 2097084 (4), 14587299 (4), 10374777 (3), 10866820 (3) (see all 83)
    i-cell disease 48.4 1 8240260 (1)
    glioblastoma 45.3 41 19774387 (6), 11494030 (6), 14730346 (4), 7820956 (4) (see all 15)
    glioma 44.9 54 10571410 (5), 7820956 (4), 17172424 (4), 11494030 (4) (see all 27)
    chronic periodontitis 44.8 7 9429076 (2), 8884632 (1), 16953825 (1), 1531511 (1) (see all 6)

    Genetic Association Database (GAD): CTSB
    Human Genome Epidemiology (HuGE) Navigator: CTSB (10 documents)

    Export disorders for CTSB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTSB gene, integrated from 10 sources (see all 1146):
    (articles sorted by number of sources associating them with CTSB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene. (PubMed id 8112600)1, 2, 3, 9 Cao L.... Sloane B.F. (Gene 1994)
    2. Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. (PubMed id 3463996)1, 2, 3 Chan S.J.... Steiner D.F. (Proc. Natl. Acad. Sci. U.S.A. 1986)
    3. Human tumour cathepsin B. Comparison with normal liver cathepsin B. (PubMed id 1637335)1, 2, 9 Moin K.... Sloane B.F. (Biochem. J. 1992)
    4. Polymorphism L26V in the cathepsin B gene may be associated with a risk of prostate cancer and differentiation. (PubMed id 19930869)1, 4, 9 Stiblar-Martincic D. and Hajdinjak T. (J. Int. Med. Res. 2009)
    5. TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes. (PubMed id 18706099)1, 4, 9 Mahurkar S....Chandak G.R. (BMC Med. Genet. 2008)
    6. Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis. (PubMed id 17990360)1, 4, 9 Mahurkar S....Chandak G.R. (World J. Gastroenterol. 2007)
    7. Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. (PubMed id 16492714)1, 4, 9 Mahurkar S....Chandak G.R. (Gut 2006)
    8. A polymorphic marker for the human cathepsin B gene. (PubMed id 11513559)1, 4, 9 MacKenzie J.R....Bickerstaffe R. (Mol. Cell. Probes 2001)
    9. The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity. (PubMed id 1868826)1, 2, 9 Musil D.... Bode W. (EMBO J. 1991)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1508 HGNC: 2527 AceView: CTSB Ensembl:ENSG00000164733 euGenes: HUgn1508
    ECgene: CTSB Kegg: 1508 H-InvDB: CTSB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CTSB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTSB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CTSB gene:
    Search GeneIP for patents involving CTSB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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