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CTSB Gene

protein-coding GIFtS: 75

GC08M011737

cathepsin B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
APPS ^², ³
CPSB ^², ³, ⁵
EC 3.4.22.1 ^³
OTTHUMP00000116009 ^²

Descriptions
APP secretase ^², ³
Cathepsin B1 ^², ³
amyloid precursor protein secretase ^²
cathepsin B ^²
cysteine protease ^²
preprocathepsin B ^²

External Ids
HGNC: 2527¹
Entrez Gene: 1508²
UniProtKB: P07858³
Ensembl: ENSG00000164733⁷

Search outside databases for aliases for CTSB gene

Previous GC identifers: GC08M011764 GC08M011571 GC08M011739

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CTSB:

The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of

disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also

known as amyloid precursor protein secretase and is involved in the proteolytic processing of

amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be

a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the

encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal

adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have

been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: CATB_HUMAN, P07858

Function: Thiol protease which is believed to participate in intracellular degradation and turnover

of proteins. Has also been implicated in tumor invasion and metastasis

Gene Wiki entry for CTSB (Cathepsin_B)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CTSB gene

Entrez Gene cytogenetic band: 8p22 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1

CTSB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M011737: (about GC identifiers)

Start:	11,737,442 bp from pter
End:	11,763,055 bp from pter
Size:	25,614 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_077531.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CATB_HUMAN, P07858 (See protein sequence)

Recommended Name: Cathepsin B precursor

Size: 339 amino acids; 37822 Da

Subunit: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond

Subcellular location: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome

fractions from stage I to stage IV

PDB structures from and Proteopedia :

1CSB (3D)

1GMY (3D)

1HUC (3D)

1PBH (3D)

2IPP (3D)

2PBH (3D)

3CBJ (3D)

3CBK (3D)

3PBH (3D)

Secondary accessions: B3KRR5 Q503A6 Q96D87

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (5 alternative transcripts):

NP_001899.1 NP_680090.1 NP_680091.1 NP_680092.1 NP_680093.1

ENSEMBL proteins:

ENSP00000342070 ENSP00000345672

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CTSB
	R&D Systems Recombinant & Natural Proteins for CTSB (Cathepsin B)
	Enzo Life Sciences proteins for CTSB
	Recombinant Proteins from Abcam (Cathepsin B)
	Human Recombinant Proteins from Abnova (CTSB)

OriGene Purified Recombinant Human Proteins (see all 2): CTSB

5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005622	intracellular	TAS	1645961
GO:0005625	soluble fraction	IEA	--
GO:0005739	mitochondrion	IEA	--
GO:0005764	lysosome	IEA	--

About this table

Antibodies for CTSB:

	Invitrogen Antibodies for CTSB
	Millipore Mono- and Polyclonal Antibodies for the study of CTSB
	Sigma-Aldrich Antibodies for CTSB
	R&D Systems Antibodies for CTSB (Cathepsin B)
	Cell Signaling Technology (CST) Antibodies for CTSB (Cathepsin B)
	Antibodies from Abcam (Cathepsin B), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CTSB)
	Novus Biologicals Antibodies for CTSB

Assays for CTSB:

	Invitrogen Assays for CTSB
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for CTSB (Cathepsin B) (see all)
	Enzo Life Sciences assays for CTSB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P07858

ProtoNet protein and cluster: P07858

2 Blocks protein families:

IPB000668 Papain cysteine protease (C1) family signature

IPB012599 Peptidase C1

UniProtKB/Swiss-Prot: CATB_HUMAN, P07858

Similarity: Belongs to the peptidase C1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CTSB)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_001908

Applied Biosystems Silencer® siRNAs for CTSB

Sigma-Aldrich siRNA and siRNA Panels for CTSB

Sigma-Aldrich shRNA for CTSB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CTSB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001908
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001908
untagged cDNA clones in CMV expression vector (see all 5): NM_001908

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_147781

UniProtKB/Swiss-Prot: CATB_HUMAN, P07858

Function: Thiol protease which is believed to participate in intracellular degradation and turnover

of proteins. Has also been implicated in tumor invasion and metastasis

Catalytic activity: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially

cleaves -Arg-Arg- -Xaa bonds in small molecule substrates (thus differing from cathepsin L). In

addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal

dipeptides

Enzyme Number (IUBMB): EC 3.4.22.1

Genatlas biochemistry entry for CTSB:

cathepsin B,lysosomal cysteine proteinase,ubiquitously expressed,?same as APP

secretase,?prorenin-processing enzyme,papain superfamily,involved in matrix degradation during

endochondral ossification,contributing to both local invasion at the early stage and remote

metastasis in colorectal cancer

11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ctsb):

behavior/neurological	cellular	digestive/alimentary	endocrine/exocrine gland	growth/size
homeostasis/metabolism	immune system	lethality-postnatal	nervous system	other
skin/coat/nails

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004197	cysteine-type endopeptidase activity	TAS	1645961
GO:0008233	peptidase activity	IEA	--
GO:0030984	kininogen binding	IEA	--
GO:0042277	peptide binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for CTSB

5/72 Interacting proteins for CTSB (ENSP00000345672³ P07858²) via UniProtKB, MINT, and/or STRING (see all 72 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SPHK1	Q9NYA1²	STRING (score=.886) MINT-3974266 MINT-3974278 MINT-3974294 MINT-3974318
AMBP	P02760²	MINT-73534 MINT-73532 MINT-73533 MINT-73528
BAT3	P46379²	MINT-63430
RGS2	P41220²	MINT-63727
CSTA	ENSP00000264474³	STRING (score=.998)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	TAS	3463996
GO:0009611	response to wounding	IEA	--
GO:0042981	regulation of apoptosis	TAS	16130169
GO:0050790	regulation of catalytic activity	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for CTSB

Sigma-Aldrich Small Molecules for CTSB:

Inhibitor

Compounds for CTSB available from Tocris Bioscience
10/56 Novoseek chemical compound relationships for CTSB gene (see all 56 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
actinidin	78.39	11	8654398 (3), 7887904 (2), 7575465 (1), 8718861 (1) (see all 8)
7-amino-4-trifluoromethylcoumarin	75.90	2	1355496 (1), 1356148 (1)
poststatin	75.26	4	8931723 (2), 8931724 (1), 8931725 (1)
z-arg-arg-nhmec	69.86	1	10900131 (1)
trypsinogen	67.56	43	12102727 (4), 7485384 (3), 8286198 (3), 11312265 (2) (see all 19)
pheg	62.11	1	16029017 (1)
cac 10	62.09	2	18803412 (1), 15701875 (1)
3-methyladenine	54.49	1	15715672 (1)
matrigel	53.11	12	16820909 (3), 15122332 (1), 15731924 (1), 9407311 (1) (see all 8)
cdp-i	48.72	1	2401660 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CTSB)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_001908

Sigma-Aldrich siRNA and siRNA Panels for CTSB

Sigma-Aldrich shRNA for CTSB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001908 NM_147780 NM_147781 NM_147782 NM_147783

REFSEQ mRNAs for CTSB gene (5 alternative transcripts):

NM_001908.3 NM_147780.2 NM_147781.2 NM_147782.2 NM_147783.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001908 NM_147780 NM_147781 NM_147782 NM_147783

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001908
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001908
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001908

Additional cDNA sequence:

AK075393.1 AK092070.1 AK097384.1 AK098296.1 AK127308.1 AK130184.1 AK290239.1 AK296845.1

AK297687.1 BC010240.1 BC095408.1 BX647765.1 BX647952.1 CR590308.1 CR591985.1 CR592456.1

CR592977.1 CR593765.1 CR594217.1 CR594314.1 CR594660.1 CR594854.1 CR595173.1 CR596339.1

CR596852.1 CR598671.1 CR601520.1 CR602375.1 CR603066.1 CR603790.1 CR605942.1 CR606913.1

CR607589.1 CR607736.1 CR608531.1 CR608828.1 CR609102.1 CR609348.1 CR609540.1 CR611342.1

CR612536.1 CR612757.1 CR613583.1 CR613700.1 CR614817.1 CR615369.1 CR615689.1 CR616354.1

CR617189.1 CR619827.1 CR621067.1 CR622240.1 CR623525.1 CR624308.1 CR626324.1 L16510.1

L38712.1 M13230.1 M14221.1 Y18460.1

24/104 DOTS entries (see all 104 ):

DT.100850425 DT.100686825 DT.100849772 DT.100059728 DT.95316962 DT.100686806 DT.100714463 DT.92061400

DT.95258060 DT.120646724 DT.120646898 DT.95258117 DT.100686820 DT.100686850 DT.120646761 DT.100686824

DT.120646609 DT.100686835 DT.100686868 DT.100641889 DT.120646644 DT.95258033 DT.92350646 DT.100686838

24/1176 AceView cDNA sequences (see all 1176 ):

BQ647205 CA390194 AA336919 BE907163 BU151673 AU076885 BE256703 AA339979

BQ705981 CR616354 AA319242 AA360603 CR594217 BG252355 BM835268 CA307068

BG572877 AW068069 CR592977 CR622240 CB145191 CB164331 BQ653516 CN483176

highest scoring ESTs for CTSB:

AA295173 AA337332 AA381342 AK092070 AK130184 AL552125 AL554048 AL709961 AL709982 AU076885

Unigene Cluster for CTSB:

Cathepsin B

Hs.520898 [show with all ESTs]

Unigene Representative Sequence: NM_147780

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CTSB (see all 12 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	·	10c	^	11a	·	11b	^	12	^	13	^	14a	·
SP1:							-		-		-		-		-		-																		-		-						-		-
SP2:							-		-		-		-		-				-																-		-						-		-
SP3:							-		-		-		-		-		-		-																-		-						-		-
SP4:
SP5:															-		-		-																-		-

ExUns:	14b	^	15	^	16a	·	16b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CTSB

2 Ensembl transcripts including schematic representations:

ENST00000345125 ENST00000353047

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CTSB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CTSB

¹ / ² / ³

11 probe-sets matching CTSB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32372_at*²^{, 3}	U95-A	1	0.38	1.00	1.00	1.00	L22569	0.20	0.50	0.38	1
227961_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
200839_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001908	0.60	1.00	0.82	1
200838_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001908	0.60	1.00	0.82	1
213274_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA020826	0.40	1.00	0.76	1
213275_x_at²	U133-A	2	1.00	0.95	--	--	--	--	--	--	--
227961_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200839_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200838_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213274_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213275_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks CTSB for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGGTGAGCC

SOURCE GeneReport for Unigene cluster: Hs.520898
Expression variation in blood from EXPOLDB for CTSB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CTSB gene from 5/19 species (see all 19 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CTSB¹	--	cathepsin B	86.23(n) 84.66(a)	486077 XM_543203.2 XP_543203.2
chimpanzee (Pan troglodytes)	CTSB¹	--	cathepsin B	95.95(n) 96.69(a)	463993 XM_519607.2 XP_519607.2
cow (Bos taurus)	CTSB¹	--	cathepsin B	85.27(n) 83.58(a)	281105 NM_174031.1 NP_776456.1
rat (Rattus norvegicus)	Ctsb¹	--	cathepsin B	80.36(n) 79.46(a)	64529 NM_022597.2 NP_072119.2
mouse (Mus musculus)	Ctsb^{1, 5}	14 (28.00 cM)⁵	cathepsin B^{1, 5}	80.26(n)¹ 79.46(a)¹	13030¹ NM_007798.2¹ NP_031824.1¹ AA389530⁵ AF062526⁵ (see all 77)

About this table Species with no ortholog for CTSB

ENSEMBL Gene Tree for CTSB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CTSB gene

CTSO²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/319 NCBI SNPs in CTSB are shown (see all 319 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 160)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs709822^1,2	A,C,F,H,O	11739722(+)	`TCCTGC/GGTCTC`	5	--	ut3¹ ese³		13	MN CSAM EA NA EU WA	1136
	rs3947^1,2	A,C,F,H,O	11739784(+)	`GGGCAG/ACAGGT`	5	--	ut3¹ ese³		15	MN CSAM EA NA EU WA	1510
--	rs6731^1,2	A,C,F,H,O	11737510(-)	`TTCATA/GACCAC`	5	--	ut3¹ ese³		9	MN EU EA WA NA	930
	rs1692821^1,2	C,F,H,O	11737397(-)	`CCATCG/ATATAC`	5	--	ng5¹		20	EA NA MN EU WA	1810
	rs709821^1,2	A,C,F,H	11740003(+)	`ACCCCG/CATCTC`	5	--	ut3¹		6	MN EU EA WA	626
	rs1736078^1,2	A,C,F,H	11739251(+)	`AGAAAC/ACTTTT`	5	--	ut3¹		12	MN NA EU EA WA	1162
	rs4841601^1,2	A,C,F,H	11737139(+)	`AGGCAT/CTGTTA`	5	--	ng5¹		12	EU EA WA NA	1052
	rs4839^1,2	C,F,H,O	11739342(+)	`CTATTT/CTCCTT`	5	--	ut3¹		13	MN NA EU EA WA	1348
	rs6730^1,2	A,C,F,H	11739613(+)	`ACACCA/GTCTCT`	5	--	ut3¹ ese³		20	NA EA MN CSAM EU WA	1558
	rs12898^1,2	A,C,F,H	11738607(-)	`ACAGGC/TTTGGT`	5	--	ut3¹		13	MN EU EA WA NA	1350

About this table

HapMap Linkage Disequilibrium images for CTSB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 116810

10/95 Novoseek disease relationships for CTSB gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	56.32	372	9524062 (7), 9499362 (6), 11147599 (6), 9770500 (6) (see all 99)
osteoclastoma	55.68	3	8467955 (2), 1540624 (1)
metastasis	54.21	102	7677635 (3), 8330299 (3), 18296264 (3), 11147599 (3) (see all 77)
senile plaques	50.08	9	1692625 (2), 1795881 (1), 7592716 (1), 1584965 (1) (see all 8)
alzheimers disease	49.98	26	1795881 (3), 7674807 (2), 11033346 (1), 11880515 (1) (see all 21)
i-cell disease	49.68	1	8240260 (1)
cancer	46.97	125	2097084 (4), 14587299 (4), 10374777 (3), 10866820 (3) (see all 78)
chronic periodontitis	45.06	7	9429076 (2), 8884632 (1), 16953825 (1), 1531511 (1) (see all 6)
glioma	43.28	50	10571410 (5), 7820956 (4), 17172424 (4), 11494030 (4) (see all 24)
glioblastoma	42.07	26	11494030 (6), 14730346 (4), 7820956 (4), 15122332 (2) (see all 10)

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Human Gene Mutation Database: CTSB
Genetic Association Database: CTSB
Human Genome Epidemiology Navigator: CTSB (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/890 PubMed articles for CTSB gene (see all 890 ):

Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene. (PubMed id 8112600)^{1, 2, 3, 4} Cao L.... Sloane B.F. (1994)
Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. (PubMed id 3463996)^{2, 3, 4} Chan S.J....Steiner D.F. (1986)
Human tumour cathepsin B. Comparison with normal liver cathepsin B. (PubMed id 1637335)^{1, 3, 4} Moin K.... Sloane B.F. (1992)
A polymorphic marker for the human cathepsin B gene. (PubMed id 11513559)^{1, 3, 6} MacKenzie J.R....Bickerstaffe R. (2001)
The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity. (PubMed id 1868826)^{1, 3, 4} Musil D.... Bode W. (1991)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)^{3, 4} Basrur V.... Appella E. (2003)
Crystal structure of the wild-type human procathepsin B at 2.5-A resolution reveals the native active site of a papain-like cysteine protease zymogen. (PubMed id 9299326)^{3, 4} Podobnik M.... Turk D. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1508	HGNC: 2527	AceView: CTSB	Ensembl:ENSG00000164733	euGenes: HUgn1508
ECgene: CTSB	H-InvDB: CTSB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CTSB	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CTSB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CTSB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CTSB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CTSB		Antibodies for CTSB
	Explore super-pooled esiRNAs		Proteins for CTSB
	Lentivirus-delivered shRNAs for CTSB		Small molecules for CTSB
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CTSB)
	Antibodies (CTSB)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CTSB (Cathepsin B)

	Recombinant Proteins (Cathepsin B)
	Antibodies (Cathepsin B)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for CTSB

	Assays/Drugs/Proteins for CTSB
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CTSB

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CTSB Gene at Home site.
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CTSB Gene

protein-coding GIFtS: 75

Aliases &
Descriptions
for CTSB

Summaries
for CTSB

Genomic Location
for CTSB

Proteins
for CTSB

Protein Domains/
Families
for CTSB

Gene Function
for CTSB

Pathways & Interactions
for CTSB

Drugs & Compounds
for CTSB

Transcripts
for CTSB

Expression
for CTSB

Orthologs
for CTSB

Paralogs
for CTSB

SNPs/Variants
for CTSB

Disorders & Mutations
for CTSB

Medical News
for CTSB

Publications
for CTSB

Search for CTSB

Genome Databases showing CTSB

Other Databases showing CTSB

Specialized Databases showing CTSB

Licensable Technologies
for CTSB

Services
for CTSB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CTSB Gene

protein-coding GIFtS: 75

Aliases & Descriptionsfor CTSB

Summariesfor CTSB

Genomic Locationfor CTSB

Proteinsfor CTSB

Protein Domains/Familiesfor CTSB

Gene Functionfor CTSB

Pathways & Interactionsfor CTSB

Drugs & Compoundsfor CTSB

Transcriptsfor CTSB

Expression for CTSB

Orthologsfor CTSB

Paralogsfor CTSB

SNPs/Variantsfor CTSB

Disorders & Mutationsfor CTSB

Medical Newsfor CTSB

Publicationsfor CTSB

Search for CTSB

Genome Databases showing CTSB

Other Databases showing CTSB

Specialized Databases showing CTSB

Licensable Technologiesfor CTSB

Servicesfor CTSB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CTSB

Summaries
for CTSB

Genomic Location
for CTSB

Proteins
for CTSB

Protein Domains/
Families
for CTSB

Gene Function
for CTSB

Pathways & Interactions
for CTSB

Drugs & Compounds
for CTSB

Transcripts
for CTSB

Expression
for CTSB

Orthologs
for CTSB

Paralogs
for CTSB

SNPs/Variants
for CTSB

Disorders & Mutations
for CTSB

Medical News
for CTSB

Publications
for CTSB

Licensable Technologies
for CTSB

Services
for CTSB