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Aliases for CTSB Gene

Aliases for CTSB Gene

  • Cathepsin B 2 3
  • CPSB 3 4 6
  • APP Secretase 3 4
  • Cathepsin B1 3 4
  • EC 3.4.22.1 4 64
  • APPS 3 4
  • Amyloid Precursor Protein Secretase 3
  • Cysteine Protease 3
  • EC 3.4.22 64

External Ids for CTSB Gene

Summaries for CTSB Gene

Entrez Gene Summary for CTSB Gene

  • The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTSB Gene

CTSB (Cathepsin B) is a Protein Coding gene. Diseases associated with CTSB include occlusion of gallbladder and adenocarcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Degradation of the extracellular matrix. GO annotations related to this gene include cysteine-type peptidase activity and cysteine-type endopeptidase activity. An important paralog of this gene is TINAG.

UniProtKB/Swiss-Prot for CTSB Gene

  • Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis

Gene Wiki entry for CTSB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSB Gene

Genomics for CTSB Gene

Genomic Location for CTSB Gene

Start:
11,842,524 bp from pter
End:
11,869,448 bp from pter
Size:
26,925 bases
Orientation:
Minus strand

Genomic View for CTSB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTSB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSB Gene

Regulatory Elements for CTSB Gene

Transcription factor binding sites by QIAGEN in the CTSB gene promoter:

Proteins for CTSB Gene

  • Protein details for CTSB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07858-CATB_HUMAN
    Recommended name:
    Cathepsin B
    Protein Accession:
    P07858
    Secondary Accessions:
    • B3KQR5
    • B3KRR5
    • Q503A6
    • Q96D87

    Protein attributes for CTSB Gene

    Size:
    339 amino acids
    Molecular mass:
    37822 Da
    Quaternary structure:
    • Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2.

    Three dimensional structures from OCA and Proteopedia for CTSB Gene

neXtProt entry for CTSB Gene

Proteomics data for CTSB Gene at MOPED

Post-translational modifications for CTSB Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys223 and Lys237
  • Glycosylation at Asn192

Domains for CTSB Gene

Gene Families for CTSB Gene

HGNC:
  • CTS :Cathepsins

UniProtKB/Swiss-Prot:

CATB_HUMAN
Family:
  • Belongs to the peptidase C1 family.:
    • P07858
genes like me logo Genes that share domains with CTSB: view

Function for CTSB Gene

Molecular function for CTSB Gene

GENATLAS Biochemistry: cathepsin B,lysosomal cysteine proteinase,ubiquitously expressed,?same as APP secretase,?prorenin-processing enzyme,papain superfamily,involved in matrix degradation during endochondral ossification,contributing to both local invasion at the early stage and remote metastasis in colorectal cancer
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg- -Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides
UniProtKB/Swiss-Prot Function: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis

Enzyme Numbers (IUBMB) for CTSB Gene

Gene Ontology (GO) - Molecular Function for CTSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IDA 22952693
GO:0005515 protein binding IPI 16237761
GO:0005518 collagen binding IDA 22952693
GO:0008233 peptidase activity IDA 7890620
GO:0008234 cysteine-type peptidase activity IDA 8612130
genes like me logo Genes that share ontologies with CTSB: view
genes like me logo Genes that share phenotypes with CTSB: view

Animal Models for CTSB Gene

MGI Knock Outs for CTSB:

miRNA for CTSB Gene

miRTarBase miRNAs that target CTSB

No data available for Transcription Factor Targeting and HOMER Transcription for CTSB Gene

Localization for CTSB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSB Gene

Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTSB Gene COMPARTMENTS Subcellular localization image for CTSB gene
Compartment Confidence
lysosome 5
vacuole 5
endosome 4
nucleus 4
extracellular 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CTSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS 22261194
GO:0005622 intracellular TAS 1645961
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CTSB: view

Pathways for CTSB Gene

genes like me logo Genes that share pathways with CTSB: view

Pathways by source for CTSB Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for CTSB Gene
1 R&D Systems pathway for CTSB Gene
2 Cell Signaling Technology pathways for CTSB Gene

Gene Ontology (GO) - Biological Process for CTSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0006508 proteolysis IDA 7890620
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0030574 collagen catabolic process TAS --
genes like me logo Genes that share ontologies with CTSB: view

Compounds for CTSB Gene

(12) ApexBio Compounds for CTSB Gene

Compound Action Cas Number
CA 074 Inhibitor of cathepsin B. [134448-10-5]
CA-074 Me irreversible inhibitor of intracellular cathepsin B. [147859-80-1]
Calpeptin Potent cathepsin L inhibitor [117591-20-5]
Cathepsin G Inhibitor I potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G. [429676-93-7]
Cathepsin S inhibitor A slow, tight-binding reversible inhibitor of recombinant cathepsin S. [1373215-15-6]
E 64d thiol protease inhibitor1 [88321-09-9]
E-64 Irriversible cysteine protease inhibitor [66701-25-5]
E-64-c inhibits cathepsin B, cathepsin H, and cathepsin L [76684-89-4]
L 006235 Potent, reversible cathepsin K inhibitor. [294623-49-7]
MDL 28170 Potent, selective inhibitor of calpain and cathepsin B. [88191-84-8]
Odanacatib (MK-0822) inhibitor of cathepsin K. [603139-19-1]
SID 26681509 Potent and reversible human cathepsin L inhibitor. [958772-66-2]

(125) Novoseek inferred chemical compound relationships for CTSB Gene

Compound -log(P) Hits PubMed IDs
cysteine 90.8 131
ca 074 89.2 13
actinidin 77.4 11
e 64d 75.8 6
7-amino-4-trifluoromethylcoumarin 75.2 2
genes like me logo Genes that share compounds with CTSB: view

Transcripts for CTSB Gene

Unigene Clusters for CTSB Gene

Cathepsin B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTSB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4:
SP5: - - - - -
SP6: - -
SP7:
SP8: - - - - -
SP9: - - - -
SP10:
SP11: - - - - -
SP12: - - - - -

ExUns: 14b ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CTSB Gene

GeneLoc Exon Structure for
CTSB
ECgene alternative splicing isoforms for
CTSB

Expression for CTSB Gene

mRNA expression in normal human tissues for CTSB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTSB Gene

SOURCE GeneReport for Unigene cluster for CTSB Gene Hs.520898

genes like me logo Genes that share expressions with CTSB: view

Orthologs for CTSB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTSB 36
  • 98.62 (n)
  • 99.41 (a)
CTSB 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CATB 37
  • 84 (a)
OneToOne
CTSB 36
  • 85.27 (n)
  • 83.58 (a)
dog
(Canis familiaris)
Mammalia CTSB 36
  • 86.23 (n)
  • 84.66 (a)
CTSB 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctsb 36
  • 80.04 (n)
  • 78.76 (a)
Ctsb 16
Ctsb 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTSB 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTSB 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctsb 36
  • 80.14 (n)
  • 78.76 (a)
chicken
(Gallus gallus)
Aves CTSB 36
  • 75.71 (n)
  • 76.4 (a)
CTSB 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTSB 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cg10992-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ctsb 36
  • 70.78 (n)
  • 73.19 (a)
MGC75969 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1055 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
ctsba 36
  • 69.72 (n)
  • 73.17 (a)
ctsba 37
  • 72 (a)
OneToMany
ctsbb 37
  • 64 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004533 36
  • 58.63 (n)
  • 60.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta CtsB1 36
  • 59.9 (n)
  • 59.69 (a)
CtsB1 37
  • 54 (a)
OneToOne
CG10992 38
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea cpr-1 37
  • 47 (a)
OneToMany
cpr-2 37
  • 43 (a)
OneToMany
cpr-3 37
  • 40 (a)
OneToMany
cpr-4 37
  • 47 (a)
OneToMany
cpr-5 37
  • 47 (a)
OneToMany
cpr-6 37
  • 40 (a)
OneToMany
F32H5.1 37
  • 36 (a)
OneToMany
F57F5.1 37
  • 46 (a)
OneToMany
W07B8.1 37
  • 39 (a)
OneToMany
W07B8.4 37
  • 47 (a)
OneToMany
Y65B4A.2 37
  • 24 (a)
OneToMany
F36D3.9 38
  • 44 (a)
cpr-4 38
  • 49 (a)
cpr-6 38
  • 49 (a)
F57F5.1 38
  • 51 (a)
W07B8.4 38
  • 49 (a)
W07B8.1 38
  • 41 (a)
F32H5.1 38
  • 38 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G02305 36
  • 55.36 (n)
  • 53.15 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.392 36
rice
(Oryza sativa)
Liliopsida Os05g0310500 36
  • 58.84 (n)
  • 55.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2385 37
  • 59 (a)
OneToOne
Species with no ortholog for CTSB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSB Gene

ENSEMBL:
Gene Tree for CTSB (if available)
TreeFam:
Gene Tree for CTSB (if available)

Paralogs for CTSB Gene

Paralogs for CTSB Gene

Pseudogenes.org Pseudogenes for CTSB Gene

genes like me logo Genes that share paralogs with CTSB: view

Variants for CTSB Gene

Sequence variations from dbSNP and Humsavar for CTSB Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3947 -- 11,844,866(+) GGGCA(A/G)CAGGT utr-variant-3-prime
rs4178 -- 11,844,379(+) GAAGC(-/TG)TAATT utr-variant-3-prime
rs4839 -- 11,844,424(+) CTATT(C/T)TCCTT utr-variant-3-prime
rs4943 -- 11,850,941(-) AGCTT(C/T)GATGC reference, synonymous-codon
rs6730 -- 11,844,695(+) ACACC(A/G/T)TCTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CTSB Gene

Variant ID Type Subtype PubMed ID
nsv890361 CNV Gain 21882294
nsv890362 CNV Loss 21882294
nsv890365 CNV Gain 21882294
nsv890366 CNV Gain 21882294
nsv890367 CNV Gain 21882294
nsv890368 CNV Loss 21882294
nsv890369 CNV Loss 21882294
esv34042 CNV Loss 18971310
nsv516685 CNV Gain+Loss 19592680
esv2668269 CNV Deletion 23128226

Relevant External Links for CTSB Gene

HapMap Linkage Disequilibrium report
CTSB
Human Gene Mutation Database (HGMD)
CTSB

Disorders for CTSB Gene

(5) University of Copenhagen DISEASES for CTSB Gene

(97) Novoseek inferred disease relationships for CTSB Gene

Disease -log(P) Hits PubMed IDs
tumors 56.5 214
osteoclastoma 54.7 3
metastasis 54.3 99
alzheimers disease 49.6 24
senile plaques 49.5 9

Relevant External Links for CTSB

Genetic Association Database (GAD)
CTSB
Human Genome Epidemiology (HuGE) Navigator
CTSB
genes like me logo Genes that share disorders with CTSB: view

No data available for UniProtKB/Swiss-Prot for CTSB Gene

Publications for CTSB Gene

  1. Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene. (PMID: 8112600) Cao L. … Sloane B.F. (Gene 1994) 2 3 4 23
  2. Human tumour cathepsin B. Comparison with normal liver cathepsin B. (PMID: 1637335) Moin K. … Sloane B.F. (Biochem. J. 1992) 3 4 23
  3. The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity. (PMID: 1868826) Musil D. … Bode W. (EMBO J. 1991) 3 4 23
  4. A polymorphic marker for the human cathepsin B gene. (PMID: 11513559) MacKenzie J.R. … Bickerstaffe R. (Mol. Cell. Probes 2001) 3 23 49
  5. Comprehensive screening for reg1alpha gene rules out association with tropical calcific pancreatitis. (PMID: 17990360) Mahurkar S. … Chandak G.R. (World J. Gastroenterol. 2007) 3 23 49

Products for CTSB Gene

  • Addgene plasmids for CTSB

Sources for CTSB Gene

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