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Aliases for CTSB Gene

Aliases for CTSB Gene

  • Cathepsin B 2 3 5
  • APP Secretase 3 4
  • Cathepsin B1 3 4
  • EC 4 61
  • APPS 3 4
  • CPSB 3 4
  • Amyloid Precursor Protein Secretase 3
  • Cysteine Protease 3
  • EC 3.4.22 61

External Ids for CTSB Gene

Previous GeneCards Identifiers for CTSB Gene

  • GC08M011764
  • GC08M011571
  • GC08M011739
  • GC08M011737
  • GC08M011700
  • GC08M010630

Summaries for CTSB Gene

Entrez Gene Summary for CTSB Gene

  • This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]

GeneCards Summary for CTSB Gene

CTSB (Cathepsin B) is a Protein Coding gene. Diseases associated with CTSB include Occlusion Of Gallbladder and Ileum Cancer. Among its related pathways are Apoptosis Modulation and Signaling and Apoptosis and Autophagy. GO annotations related to this gene include peptidase activity and cysteine-type peptidase activity. An important paralog of this gene is TINAGL1.

UniProtKB/Swiss-Prot for CTSB Gene

  • Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

Gene Wiki entry for CTSB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTSB Gene

Genomics for CTSB Gene

Regulatory Elements for CTSB Gene

Enhancers for CTSB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CTSB on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CTSB gene promoter:

Genomic Location for CTSB Gene

11,842,524 bp from pter
11,869,448 bp from pter
26,925 bases
Minus strand

Genomic View for CTSB Gene

Genes around CTSB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTSB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTSB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTSB Gene

Proteins for CTSB Gene

  • Protein details for CTSB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cathepsin B
    Protein Accession:
    Secondary Accessions:
    • B3KQR5
    • B3KRR5
    • Q503A6
    • Q96D87

    Protein attributes for CTSB Gene

    339 amino acids
    Molecular mass:
    37822 Da
    Quaternary structure:
    • Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2.

    Three dimensional structures from OCA and Proteopedia for CTSB Gene

neXtProt entry for CTSB Gene

Post-translational modifications for CTSB Gene

  • Ubiquitination at Lys 223 and Lys 237
  • Glycosylation at Asn 192
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CTSB (CTSB)

Assay Products

  • Enzo Life Sciences assays for CTSB
  • Cloud-Clone Corp Assay Kits for CTSB

Domains & Families for CTSB Gene

Gene Families for CTSB Gene

Suggested Antigen Peptide Sequences for CTSB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C1 family.
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with CTSB: view

Function for CTSB Gene

Molecular function for CTSB Gene

GENATLAS Biochemistry:
cathepsin B,lysosomal cysteine proteinase,ubiquitously expressed,?same as APP secretase,?prorenin-processing enzyme,papain superfamily,involved in matrix degradation during endochondral ossification,contributing to both local invasion at the early stage and remote metastasis in colorectal cancer
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg- -Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
UniProtKB/Swiss-Prot Function:
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

Enzyme Numbers (IUBMB) for CTSB Gene

Gene Ontology (GO) - Molecular Function for CTSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IDA 6203523
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 6203523
GO:0005518 collagen binding IDA 22952693
GO:0008233 peptidase activity IDA 7890620
genes like me logo Genes that share ontologies with CTSB: view
genes like me logo Genes that share phenotypes with CTSB: view

Animal Models for CTSB Gene

MGI Knock Outs for CTSB:

Animal Model Products

  • Taconic Biosciences Mouse Models for CTSB

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CTSB

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTSB Gene

Localization for CTSB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTSB Gene

Lysosome. Melanosome. Secreted, extracellular space. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Jensen Localization Image for CTSB Gene COMPARTMENTS Subcellular localization image for CTSB gene
Compartment Confidence
endosome 5
extracellular 5
lysosome 5
nucleus 5
vacuole 5
mitochondrion 3
plasma membrane 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CTSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS 22261194
GO:0005622 intracellular TAS 1645961
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CTSB: view

Pathways & Interactions for CTSB Gene

genes like me logo Genes that share pathways with CTSB: view

Pathways by source for CTSB Gene

1 GeneGo (Thomson Reuters) pathway for CTSB Gene
1 R&D Systems pathway for CTSB Gene

Gene Ontology (GO) - Biological Process for CTSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0006508 proteolysis IDA 7890620
GO:0006914 autophagy IEA --
GO:0007283 spermatogenesis IEA --
GO:0007519 skeletal muscle tissue development IEA --
genes like me logo Genes that share ontologies with CTSB: view

No data available for SIGNOR curated interactions for CTSB Gene

Drugs & Compounds for CTSB Gene

(81) Drugs for CTSB Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-Aminoethanimidic Acid Experimental Pharma Target 0
2-Pyridinethiol Experimental Pharma Target 0
3-Amino-4-Oxybenzyl-2-Butanone Experimental Pharma Target 0
3-Methylphenylalanine Experimental Pharma Target 0

(66) Additional Compounds for CTSB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(9) ApexBio Compounds for CTSB Gene

Compound Action Cas Number
CA 074 Cathepsin B inhibitor 134448-10-5
CA-074 Me Cathepsin B inhibitor 147859-80-1
Calpain Inhibitor I, ALLN Calpain I/II/ B/L inhibitor 110044-82-1
Calpain Inhibitor II, ALLM Calpain inhibitor 136632-32-1
Cathepsin Inhibitor 1 Cathepsin inhibitor 225120-65-0
E 64d Cysteine protease inhibitor 88321-09-9
E-64 Cysteine protease inhibitor,irriversible 66701-25-5
E-64-c Inhibitor of cysteine proteinases 76684-89-4
MDL 28170 Calpain and cathepsin B inhibitor, selective 88191-84-8
genes like me logo Genes that share compounds with CTSB: view

Transcripts for CTSB Gene

Unigene Clusters for CTSB Gene

Cathepsin B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CTSB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTSB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP5: - - - - -
SP6: - -
SP8: - - - - -
SP9: - - - -
SP11: - - - - -
SP12: - - - - -

ExUns: 14b ^ 15 ^ 16a · 16b

Relevant External Links for CTSB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTSB Gene

mRNA expression in normal human tissues for CTSB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTSB Gene

This gene is overexpressed in Amniocyte (16.2) and Nasal epithelium (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTSB Gene

NURSA nuclear receptor signaling pathways regulating expression of CTSB Gene:


SOURCE GeneReport for Unigene cluster for CTSB Gene:

genes like me logo Genes that share expression patterns with CTSB: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CTSB Gene

Orthologs for CTSB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTSB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTSB 34
  • 85.27 (n)
  • 83.58 (a)
  • 84 (a)
(Canis familiaris)
Mammalia CTSB 34
  • 86.23 (n)
  • 84.66 (a)
  • 85 (a)
(Mus musculus)
Mammalia Ctsb 34
  • 80.04 (n)
  • 78.76 (a)
Ctsb 16
Ctsb 35
  • 78 (a)
(Pan troglodytes)
Mammalia CTSB 34
  • 98.62 (n)
  • 99.41 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Ctsb 34
  • 80.14 (n)
  • 78.76 (a)
(Monodelphis domestica)
Mammalia CTSB 35
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia CTSB 35
  • 51 (a)
(Gallus gallus)
Aves CTSB 34
  • 75.71 (n)
  • 76.4 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia CTSB 35
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ctsb 34
  • 70.78 (n)
  • 73.19 (a)
MGC75969 34
African clawed frog
(Xenopus laevis)
Amphibia cg10992-prov 34
(Danio rerio)
Actinopterygii -- 34
ctsba 34
  • 69.72 (n)
  • 73.17 (a)
ctsba 35
  • 72 (a)
ctsbb 35
  • 64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1055 34
fruit fly
(Drosophila melanogaster)
Insecta CG10992 36
  • 58 (a)
CtsB1 34
  • 59.9 (n)
  • 59.69 (a)
CtsB1 35
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004533 34
  • 58.63 (n)
  • 60.26 (a)
(Caenorhabditis elegans)
Secernentea cpr-4 36
  • 49 (a)
cpr-6 36
  • 49 (a)
F32H5.1 36
  • 38 (a)
F36D3.9 36
  • 44 (a)
F57F5.1 36
  • 51 (a)
W07B8.1 36
  • 41 (a)
W07B8.4 36
  • 49 (a)
cpr-1 35
  • 47 (a)
cpr-2 35
  • 43 (a)
cpr-3 35
  • 40 (a)
cpr-4 35
  • 47 (a)
cpr-5 35
  • 47 (a)
cpr-6 35
  • 40 (a)
F32H5.1 35
  • 36 (a)
F57F5.1 35
  • 46 (a)
W07B8.1 35
  • 39 (a)
W07B8.4 35
  • 47 (a)
Y65B4A.2 35
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G02305 34
  • 55.36 (n)
  • 53.15 (a)
(Hordeum vulgare)
Liliopsida Hv.392 34
(Oryza sativa)
Liliopsida Os05g0310500 34
  • 58.84 (n)
  • 55.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2385 35
  • 59 (a)
Species where no ortholog for CTSB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTSB Gene

Gene Tree for CTSB (if available)
Gene Tree for CTSB (if available)

Paralogs for CTSB Gene

Paralogs for CTSB Gene Pseudogenes for CTSB Gene

genes like me logo Genes that share paralogs with CTSB: view

Variants for CTSB Gene

Sequence variations from dbSNP and Humsavar for CTSB Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs12338 - 11,853,379(-) ATCCC(A/C/G/T)TGTCG reference, missense
rs17573 - 11,847,141(-) CAATA(A/G/T)CGAGA reference, missense
rs1803250 - 11,852,665(-) ACATG(A/G/T)GCTAC reference, missense
rs11548596 - 11,850,921(-) ATGGC(C/T)ACAGT reference, missense
rs1004449 -- 11,863,948(-) AGATA(C/G)TTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTSB Gene

Variant ID Type Subtype PubMed ID
dgv2039e212 CNV loss 25503493
esv2668269 CNV deletion 23128226
esv2762727 CNV loss 21179565
esv34042 CNV loss 18971310
esv3572516 CNV loss 25503493
esv3572517 CNV loss 25503493
esv3616259 CNV loss 21293372
esv3616260 CNV loss 21293372
nsv1018042 CNV gain 25217958
nsv1032739 CNV loss 25217958
nsv1034132 CNV gain 25217958
nsv516685 CNV gain+loss 19592680
nsv610293 CNV gain 21841781

Variation tolerance for CTSB Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.40; 90.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTSB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTSB Gene

Disorders for CTSB Gene

MalaCards: The human disease database

(20) MalaCards diseases for CTSB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
occlusion of gallbladder
  • obstruction of gallbladder
ileum cancer
  • ileal neoplasm
tropical calcific pancreatitis
  • fibrocalculous pancreatic diabetes
cerebral aneurysms
  • cerebral aneurysm
  • stenosis of larynx
- elite association - COSMIC cancer census association via MalaCards
Search CTSB in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTSB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CTSB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTSB Gene

Publications for CTSB Gene

  1. Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene. (PMID: 8112600) Cao L. … Sloane B.F. (Gene 1994) 2 3 4 22 65
  2. Polymorphism L26V in the cathepsin B gene may be associated with a risk of prostate cancer and differentiation. (PMID: 19930869) Stiblar-Martincic D. … Hajdinjak T. (J. Int. Med. Res. 2009) 3 22 46 65
  3. Association of cathepsin B gene polymorphisms with tropical calcific pancreatitis. (PMID: 16492714) Mahurkar S. … Chandak G.R. (Gut 2006) 3 22 46 65
  4. Human tumour cathepsin B. Comparison with normal liver cathepsin B. (PMID: 1637335) Moin K. … Sloane B.F. (Biochem. J. 1992) 3 4 22 65
  5. The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity. (PMID: 1868826) Musil D. … Bode W. (EMBO J. 1991) 3 4 22 65

Products for CTSB Gene

  • Addgene plasmids for CTSB

Sources for CTSB Gene

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