Aliases for CTSA Gene
External Ids for CTSA Gene
Previous HGNC Symbols for CTSA Gene
Previous GeneCards Identifiers for CTSA Gene
This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015]
GeneCards Summary for CTSA Gene
CTSA (Cathepsin A) is a Protein Coding gene. Diseases associated with CTSA include galactosialidosis and ring chromosome 20. Among its related pathways are Immune System and Transport to the Golgi and subsequent modification. GO annotations related to this gene include enzyme activator activity and serine-type carboxypeptidase activity. An important paralog of this gene is CPVL.
UniProtKB/Swiss-Prot for CTSA Gene
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.
Cathepsins are a group of lysosomal proteases that have a key role in cellular protein turnover. The term cathepsin includes serine proteases (cathepsins A and G), aspartic proteases (cathepsin D and E) as well as the cysteine proteases (cathepsins B, C, F, H, K, L, O, S, W and Z).