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Aliases for CTRL Gene

Aliases for CTRL Gene

  • Chymotrypsin-Like 2 3
  • CTRL1 3 4
  • Chymotrypsin-Like Protease CTRL-1 3
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for CTRL Gene

Previous GeneCards Identifiers for CTRL Gene

  • GC16M058658
  • GC16M068341
  • GC16M067698
  • GC16M067740
  • GC16M067741
  • GC16M066521
  • GC16M067963
  • GC16M053837

Summaries for CTRL Gene

GeneCards Summary for CTRL Gene

CTRL (Chymotrypsin-Like) is a Protein Coding gene. Diseases associated with CTRL include netherton syndrome and severe acute respiratory syndrome. Among its related pathways are Pancreatic secretion and Protein digestion and absorption. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA2B.

Gene Wiki entry for CTRL Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTRL Gene

Genomics for CTRL Gene

Regulatory Elements for CTRL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTRL Gene

Start:
67,927,640 bp from pter
End:
67,932,414 bp from pter
Size:
4,775 bases
Orientation:
Minus strand

Genomic View for CTRL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTRL Gene

Proteins for CTRL Gene

  • Protein details for CTRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40313-CTRL_HUMAN
    Recommended name:
    Chymotrypsin-like protease CTRL-1
    Protein Accession:
    P40313
    Secondary Accessions:

    Protein attributes for CTRL Gene

    Size:
    264 amino acids
    Molecular mass:
    28002 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTRL Gene

Proteomics data for CTRL Gene at MOPED

Selected DME Specific Peptides for CTRL Gene

Post-translational modifications for CTRL Gene

  • Glycosylation at Asn114
  • Modification sites at PhosphoSitePlus

Other Protein References for CTRL Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for CTRL Gene

Suggested Antigen Peptide Sequences for CTRL Gene

Graphical View of Domain Structure for InterPro Entry

P40313

UniProtKB/Swiss-Prot:

CTRL_HUMAN :
  • P40313
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CTRL: view

No data available for Gene Families for CTRL Gene

Function for CTRL Gene

Molecular function for CTRL Gene

GENATLAS Biochemistry: chymotrypsin protease-like,pancreas

Enzyme Numbers (IUBMB) for CTRL Gene

Gene Ontology (GO) - Molecular Function for CTRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0008233 peptidase activity --
GO:0008236 serine-type peptidase activity --
genes like me logo Genes that share ontologies with CTRL: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTRL

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CTRL Gene

Localization for CTRL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTRL Gene COMPARTMENTS Subcellular localization image for CTRL gene
Compartment Confidence
extracellular 4
cytosol 2
lysosome 2
nucleus 2
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 9065485
genes like me logo Genes that share ontologies with CTRL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CTRL Gene

Pathways for CTRL Gene

genes like me logo Genes that share pathways with CTRL: view

Pathways by source for CTRL Gene

Gene Ontology (GO) - Biological Process for CTRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007586 digestion TAS 9065485
genes like me logo Genes that share ontologies with CTRL: view

Compounds for CTRL Gene

(58) Novoseek inferred chemical compound relationships for CTRL Gene

Compound -log(P) Hits PubMed IDs
zlyck 82.5 2
chymostatin 81.9 6
clasto-lactacystinbeta-lactone 77.7 2
3,4-dichloroisocoumarin 74.3 2
tpck 73.4 7
genes like me logo Genes that share compounds with CTRL: view

Transcripts for CTRL Gene

mRNA/cDNA for CTRL Gene

Unigene Clusters for CTRL Gene

Chymotrypsin-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTRL

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CTRL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTRL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - -
SP6: - -
SP7: -
SP8:
SP9: - -
SP10: - -
SP11:
SP12:

ExUns: 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CTRL Gene

GeneLoc Exon Structure for
CTRL
ECgene alternative splicing isoforms for
CTRL

Expression for CTRL Gene

mRNA expression in normal human tissues for CTRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTRL Gene

This gene is overexpressed in Pancreas (49.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CTRL Gene

SOURCE GeneReport for Unigene cluster for CTRL Gene Hs.654546

genes like me logo Genes that share expressions with CTRL: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CTRL Gene

Orthologs for CTRL Gene

This gene was present in the common ancestor of animals.

Orthologs for CTRL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTRL 35
  • 99.37 (n)
  • 98.48 (a)
CTRL 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTRB1 36
  • 54 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CTRL 35
  • 88.04 (n)
  • 88.31 (a)
CTRL 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctrl 35
  • 84.01 (n)
  • 85.48 (a)
Ctrl 16
Ctrl 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTRL 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTRL 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctrl 35
  • 84.95 (n)
  • 86.69 (a)
chicken
(Gallus gallus)
Aves CTRL 35
  • 70.07 (n)
  • 66.53 (a)
lizard
(Anolis carolinensis)
Reptilia CTRL 36
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ctrl 35
  • 65.17 (n)
  • 65.31 (a)
ctrl 36
  • 62 (a)
OneToMany
CTRL (1 of 3) 36
  • 56 (a)
OneToMany
CTRL (3 of 3) 36
  • 49 (a)
OneToMany
Dr.4930 35
fruit fly
(Drosophila melanogaster)
Insecta CG10469 36
  • 31 (a)
ManyToMany
CG10472 36
  • 29 (a)
ManyToMany
CG10477 36
  • 31 (a)
ManyToMany
CG11529 36
  • 26 (a)
ManyToMany
CG18179 36
  • 26 (a)
ManyToMany
CG18180 36
  • 27 (a)
ManyToMany
CG3088 36
  • 24 (a)
ManyToMany
CG6462 36
  • 26 (a)
ManyToMany
CG6592 36
  • 19 (a)
ManyToMany
CG7542 36
  • 34 (a)
ManyToMany
CG8329 36
  • 25 (a)
ManyToMany
CG8952 36
  • 31 (a)
ManyToMany
Jon25Bi 36
  • 27 (a)
ManyToMany
Jon25Bii 36
  • 29 (a)
ManyToMany
Jon25Biii 36
  • 29 (a)
ManyToMany
Jon44E 36
  • 33 (a)
ManyToMany
Jon65Ai 36
  • 28 (a)
ManyToMany
Jon65Aii 36
  • 27 (a)
ManyToMany
Jon65Aiii 36
  • 31 (a)
ManyToMany
Jon65Aiv 36
  • 33 (a)
ManyToMany
Jon66Ci 36
  • 29 (a)
ManyToMany
Jon66Cii 36
  • 29 (a)
ManyToMany
Jon74E 36
  • 19 (a)
ManyToMany
Jon99Ci 36
  • 28 (a)
ManyToMany
Jon99Cii 36
  • 31 (a)
ManyToMany
Jon99Ciii 36
  • 31 (a)
ManyToMany
Jon99Fi 36
  • 30 (a)
ManyToMany
Jon99Fii 36
  • 30 (a)
ManyToMany
sphinx1 36
  • 20 (a)
ManyToMany
sphinx2 36
  • 22 (a)
ManyToMany
yip7 36
  • 31 (a)
ManyToMany
CG11836 37
  • 39 (a)
mas 37
  • 36 (a)
Sb 37
  • 37 (a)
CG6483 37
  • 35 (a)
CG7542 37
  • 34 (a)
BcDNA:LD13269 37
  • 34 (a)
CG6467 37
  • 38 (a)
CG11824 37
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
ManyToMany
Species with no ortholog for CTRL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTRL Gene

ENSEMBL:
Gene Tree for CTRL (if available)
TreeFam:
Gene Tree for CTRL (if available)

Paralogs for CTRL Gene

Paralogs for CTRL Gene

genes like me logo Genes that share paralogs with CTRL: view

Variants for CTRL Gene

Sequence variations from dbSNP and Humsavar for CTRL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1079724 -- 67,931,689(-) GTGGG(C/T)AAAAG intron-variant
rs1079725 -- 67,931,647(-) AACAG(G/T)CCTGC intron-variant
rs1079726 -- 67,931,031(-) GCCCA(C/T)CCCCA intron-variant
rs1134760 - 67,930,300(+) GCAGA(C/T)GTGCT reference, missense
rs2549809 -- 67,932,427(+) TGTAC(A/G)CAAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CTRL Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680

Relevant External Links for CTRL Gene

HapMap Linkage Disequilibrium report
CTRL
Human Gene Mutation Database (HGMD)
CTRL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTRL Gene

Disorders for CTRL Gene

(2) University of Copenhagen DISEASES for CTRL Gene

(14) Novoseek inferred disease relationships for CTRL Gene

Disease -log(P) Hits PubMed IDs
netherton syndrome 57.7 1
prostate cancer 40.4 9
tumors 28.9 12
cancer 28.2 6
leukemia 26.7 3
genes like me logo Genes that share disorders with CTRL: view

No data available for UniProtKB/Swiss-Prot for CTRL Gene

Publications for CTRL Gene

  1. A tight cluster of five unrelated human genes on chromosome 16q22.1. (PMID: 8268911) Larsen F. … Prydz H. (Hum. Mol. Genet. 1993) 2 3 4 23
  2. Chymotrypsin-like protease (chymase) mediates endothelial activation by factors derived from preeclamptic placentas. (PMID: 19494363) Yang Gu . … Yuping Wang . (Reprod Sci 2009) 3 23
  3. Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsia. (PMID: 19126871) Gu Y. … Wang Y. (Reprod Sci 2009) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for CTRL Gene

Sources for CTRL Gene

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