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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTRL Gene

protein-coding   GIFtS: 57
GCID: GC16M067963

chymotrypsin-like

 Explore 38 diseases affiliated with
CTRL via our new
 Human Malady Compendium 
Biological research products
for CTRL
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chymotrypsin-Like1
CTRL12 3
Chymotrypsin-Like Protease CTRL-12
EC 3.4.21.-3
EC 3.4.218

External Ids:    HGNC: 25241   Entrez Gene: 15062   Ensembl: ENSG000001410867   OMIM: 1188885   UniProtKB: P403133   

Export aliases for CTRL gene to outside databases

Previous GC identifers: GC16M058658 GC16M068341 GC16M067698 GC16M067740 GC16M067741 GC16M066521 GC16M053837


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for CTRL


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTRL gene promoter:
         GR   p53   COMP1   GR-beta   GR-alpha   LCR-F1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTRL promoter sequence
   Search SABiosciences Chromatin IP Primers for CTRL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTRL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

CTRL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTRL gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M067963:  view genomic region     (about GC identifiers)

Start:
67,961,543 bp from pter      End:
67,966,317 bp from pter
Size:
4,775 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CTRL_HUMAN, P40313 (See protein sequence)
Recommended Name: Chymotrypsin-like protease CTRL-1 precursor  
Size: 264 amino acids; 28002 Da

Explore the universe of human proteins at neXtProt for CTRL: NX_P40313

4/7 DME Specific Peptides for CTRL (P40313) (see all 7)
 FCGGSLI  GDSGGPL  WPWQVSL  HFCGGSL 

CTRL Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001898.1  
ENSEMBL proteins: 
 ENSP00000458537   ENSP00000461842   ENSP00000458598  

Human Recombinant Protein Products: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein: CTRL
OriGene Protein Over-expression Lysate: CTRL
OriGene Custom Protein Services for CTRL 
GenScript Custom Purified and Recombinant Proteins Services for CTRL
Novus Biologicals CTRL Protein
Novus Biologicals CTRL Lysate
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins
Uscn Proteins for CTRL

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space TAS9065485


CTRL for ontologies           About GeneDecksing



CTRL Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of CTRL
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for CTRL 
GenScript Custom Superior Antibodies Services for CTRL
Novus Biologicals CTRL Antibodies
Abcam antibodies for CTRL 
Uscn Antibodies for CTRL
Search ThermoFisher Antibodies for CTRL

Assay Products for CTRL: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Immunoassay Development
Browse OriGene Fluorogenic Cell Assay Kits
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CTRL
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for CTRL


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CTRL for domains           About GeneDecksing

4 InterPro domains/families:
 IPR001314 Peptidase_S1A
 IPR001254 Peptidase_S1
 IPR018114 Peptidase_S1_AS
 IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry P40313

ProtoNet protein and cluster: P40313

2 Blocks protein families:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: CTRL_HUMAN, P40313
Similarity: Belongs to the peptidase S1 family
Similarity: Contains 1 peptidase S1 domain


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:
     Genatlas biochemistry entry for CTRL:
chymotrypsin protease-like,pancreas

Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

miRNA
Products:
    
Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTRL
2 QIAGEN miScript miRNA Assays for microRNAs that regulate CTRL:
hsa-miR-4328 hsa-miR-143*
SwitchGear 3'UTR luciferase reporter plasmidCTRL 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTRL (see all 6)
OriGene siRNA: CTRL
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTRL

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CTRL

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTRL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTRL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: CTRL (NM_001907)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRL
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRL 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CTRL
Search LifeMap BioReagents cell lines for CTRL

In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTRL

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004252serine-type endopeptidase activity IEA--
GO:0008233peptidase activity ----


CTRL for ontologies           About GeneDecksing



(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Protein digestion and absorption
Protein digestion and absorption1.00
2Pancreatic secretion
Pancreatic secretion1.00

Pathway sources
See GeneCards unified pathways
Show all pathways



2         Kegg Pathways  (Kegg details for CTRL):
    Pancreatic secretion
Protein digestion and absorption


CTRL for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTRL

2 Interacting proteins for CTRL (P403132, 3) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ING1Q9UK532, 3MINT-6616081 I2D: score=1 
SERPINA3P010113I2D: score=2 
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--
GO:0007586digestion TAS9065485


CTRL for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CTRL for compounds           About GeneDecksing

EMD Millipore small molecules for CTRL:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CTRL
10/58 Novoseek chemical compound relationships for CTRL gene (see all 58)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
zlyck 82.5 4 1874738 (1), 1653805 (1)
chymostatin 81.9 6 11112426 (1), 8031148 (1), 8022661 (1), 8458433 (1) (see all 6)
clasto-lactacystinbeta-lactone 77.7 2 9601040 (1), 16719460 (1)
3,4-dichloroisocoumarin 74.3 4 1356435 (1), 8431436 (1)
tpck 73.4 8 9178191 (2), 11112426 (1), 19653099 (1), 15197350 (1) (see all 6)
lactacystin 73.3 9 10856705 (1), 16941495 (1), 17140599 (1), 12146975 (1)
bortezomib 71.6 14 18502982 (2), 19946334 (2), 19020781 (1), 17616698 (1) (see all 6)
serine 71.2 36 8363563 (1), 11708923 (1), 15654079 (1), 19281249 (1) (see all 34)
n-acetyl-leu-leu-methioninal 67.4 1 8431436 (1)
mg 132 67.3 2 18565852 (1), 17352013 (1)

Search CenterWatch for drugs/clinical trials and news about CTRL 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CTRL gene: 
NM_001907.2  

Unigene Cluster for CTRL:

Chymotrypsin-like
Hs.654546  [show with all ESTs]
Unigene Representative Sequence: BM918604
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000573845 ENST00000574481(uc002euw.3) ENST00000572144 ENST00000576915
ENST00000571044 ENST00000571605 ENST00000576408 ENST00000575302

miRNA
Products:
     
Browse 3'-UTR reporter clones for miRNA target validation
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTRL
2 QIAGEN miScript miRNA Assays for microRNAs that regulate CTRL:
hsa-miR-4328 hsa-miR-143*
SwitchGear 3'UTR luciferase reporter plasmidCTRL 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTRL (see all 6)
OriGene siRNA: CTRL
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTRL
Clone
Products:
     
OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTRL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTRL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: CTRL (NM_001907)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRL
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRL 
Primer
Products:
    
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTRL
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTRL
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTRL
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTRL

Additional cDNA sequence: 

AK223172.1 BC039716.1 BC063475.1 X71877.1 

5 DOTS entries:

DT.441944  DT.97796543  DT.120704986  DT.100796135  DT.86840959 

24/282 AceView cDNA sequences (see all 282):

CF528911 BM832430 BU074473 CD672577 AA587209 BM792628 AW270020 BE466922 
CD365722 BQ083171 BU737642 X71877 BM831608 BM781750 CB241116 NM_001907 
AI342523 BI771225 BI821068 BM834564 BG392300 AW075764 BI833975 BI834199 

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CTRL (see all 12)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^
SP1:                                      -     -                       -     -                                                                                 
SP2:                                                                                                              -                                   -         
SP3:                                                                                                              -     -           -                           
SP4:                                      -     -                                                                                                               
SP5:                                      -     -                                                                                                               

ExUns: 15 ^ 16a · 16b
SP1:                  
SP2:                  
SP3:                  
SP4:                  
SP5:                  


ECgene alternative splicing isoforms for CTRL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CTRL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGAGGCCGG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

CTRL expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
PancreasIslets of LangerhansMature Beta CellsPancreas
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

Genevestigator expression for CTRL

SOURCE GeneReport for Unigene cluster: Hs.654546
    SABiosciences Custom PCR Arrays for CTRL
Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTRL
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTRL
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTRL
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTRL
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTRL

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CTRL gene from 4/17 species (see all 17)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves CTRL1 chymotrypsin-like 68.58(n)
64.12(a)
  427531  XM_425105.3  XP_425105.1 
lizard
(Anolis carolinensis)
Reptilia CTRL6
--
71(a)
1 ↔ 1
GL343295.1(474771-489379)
zebrafish
(Danio rerio)
Actinopterygii Dr.49302 Transcribed sequence with weak similarity to protein more 76.15(n)    CF594751.1 
fruit fly
(Drosophila melanogaster)
Insecta CG118363
CG317281
serine-type endopeptidase3
CG317281
39(a)
(best of 8)3
48.26(n)1
39.57(a)1
  96B203
347311  NM_165031.31  NP_723797.31 


ENSEMBL Gene Tree for CTRL (if available)
TreeFam Gene Tree for CTRL (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CTRL gene
CTRB12  CELA12  CELA3A2  CELA2B2  CTRC2  CTRB22  CELA2A2  CELA3B2  
18/120 SIMAP similar genes for CTRL using alignment to 4 protein entries:     CTRL_HUMAN (see all proteins) (see all similar genes):
FLJ00366    CTRB1    CTRB2    TMPRSS3    DKFZp586F0824    CELA2B
PRSS42    CELA2A    ELA2A    CELA1    CELA3B    KLK11
KLKB1    OVCH1    ELA2B    F11    KLK7    PROC1

CTRL for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/126 NCBI SNPs in CTRL are shown (see all 126    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1911049161,2
--67963033(+) AAGCCC/TCTTCC 2 -- ut31 int10--------
rs1146361081,2
F,--67963044(+) TCCACA/TGCTGC 2 -- int1 ut311Minor allele frequency- T:0.02WA 118
rs25498121,2
C,H--67963069(+) ATGGGG/CCCAGG 2 -- int1 ut314Minor allele frequency- C:0.00NS EA 416
rs1840706261,2
--67963143(+) TCAGCC/TTCTGC 2 -- int1 ut310--------
rs1868842801,2
--67963262(+) CCTACC/TGTCCC 2 -- ut31 int10--------
rs1503405461,2
--67963270(+) CCCCAA/GTGCCC 2 -- ut31 int10--------
rs80598241,2
C,F,A,H,--67963284(+) GGGCAG/AGAGGC 2 -- int1 ut3111Minor allele frequency- A:0.11NS EA NA WA 1386
rs1449911581,2
--67963291(+) AGGCAA/GTGGAG 2 -- ut31 int10--------
rs1420923561,2
--67963294(+) CAGTGC/GAGAAC 2 -- ut31 int10--------
rs1929717541,2
--67963382(+) CTCTTA/GCCCAG 2 -- int1 ut310--------

HapMap Linkage Disequilibrium report for CTRL (67961543 - 67966317 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for CTRL: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTRL
DNA2.0 Custom Variant and Variant Library Synthesis for CTRL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CTRL for disorders           About GeneDecksing

OMIM gene information: 118888    OMIM disorders: --

20/38 diseases for CTRL (see all 38):    About MalaCards
netherton syndrome    severe acute respiratory syndrome    jmp syndrome    mouth disease
newcastle disease    acute myeloid leukemia    myeloid leukemia    hepatitis a
cataract    balanitis    lymphoblastic lymphoma    multiple myeloma
alzheimer's disease    gastric cancer    encephalomyelitis    parkinson's disease
vaginitis    prostate cancer    breast cancer    duodenitis

2 diseases from the University of Copenhagen DISEASES database for CTRL:
Severe acute respiratory syndrome     Multiple myeloma

10/14 Novoseek disease relationships for CTRL gene (see all 14)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
netherton syndrome 57.7 1 16628198 (1)
prostate cancer 40.4 10 17541980 (2), 16651429 (1), 17308104 (1), 18304598 (1) (see all 8)
tumors 28.9 13 10894830 (1), 12460905 (1), 7957109 (1), 19671918 (1) (see all 12)
cancer 28.2 7 20514399 (2), 16455650 (1), 17982703 (1), 17541980 (1) (see all 5)
leukemia 26.7 3 14960234 (1), 15066131 (1), 18773885 (1)
alzheimers disease 19.9 2 10386971 (1), 8336143 (1)
breast cancer 17.7 5 15746161 (1), 19337512 (1), 19911377 (1), 16806088 (1) (see all 5)
metastasis 3.55 1 10894830 (1)
necrosis 0 1 7957109 (1)
cataract 0 5 17162884 (3)


Export disorders for CTRL gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CTRL gene, integrated from 9 sources (see all 232):
(articles sorted by number of sources associating them with CTRL)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A tight cluster of five unrelated human genes on chromosome 16q22.1. (PubMed id 8268911)1, 2, 3, 9 Larsen F.... Prydz H. (1993)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsia. (PubMed id 19126871)1, 9 Gu Y....Wang Y. (2009)
  4. Chymotrypsin-like protease (chymase) mediates endothe lial activation by factors derived from preeclamptic placentas. (PubMed id 19494363)1, 9 Yang Gu ....Yuping Wang . (2009)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  6. Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux. (PubMed id 12231569)1 Lee M....Kovanen P.T. (2002)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. A novel human chymotrypsin-like digestive enzyme. (PubMed id 9065485)1 Reseland J.E....Prydz H. (1997)
  9. Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3). (PubMed id 8812482)1 Mastroianni N.... Casari G. (1996)
  10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1506 HGNC: 2524 AceView: CTRLandPSMB10 Ensembl:ENSG00000141086 euGenes: HUgn1506
ECgene: CTRL Kegg: 1506 H-InvDB: CTRL

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CTRL Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CTRL gene:
Search GeneIP for patents involving CTRL

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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 Regulatory tfbs in CTRL promoter
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