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CTRL Gene

protein-coding   GIFtS: 60
GCID: GC16M067963

Chymotrypsin-Like

  See CTRL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
chymotrypsin-like1 2
CTRL12 3
Chymotrypsin-Like Protease CTRL-12
EC 3.4.21.-3
EC 3.4.218

External Ids:    HGNC: 25241   Entrez Gene: 15062   Ensembl: ENSG000001410867   OMIM: 1188885   UniProtKB: P403133   

Export aliases for CTRL gene to outside databases

Previous GC identifers: GC16M058658 GC16M068341 GC16M067698 GC16M067740 GC16M067741 GC16M066521 GC16M053837


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CTRL Gene:
CTRL (chymotrypsin-like) is a protein-coding gene. Diseases associated with CTRL include severe acute respiratory syndrome, and netherton syndrome. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CTRC.

Gene Wiki entry for CTRL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTRL gene promoter:
         GR   p53   COMP1   GR-beta   GR-alpha   LCR-F1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTRL promoter sequence
   Search Chromatin IP Primers for CTRL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTRL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

CTRL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTRL gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M067963:  view genomic region     (about GC identifiers)

Start:
67,961,543 bp from pter      End:
67,966,317 bp from pter
Size:
4,775 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CTRL_HUMAN, P40313 (See protein sequence)
Recommended Name: Chymotrypsin-like protease CTRL-1 precursor  
Size: 264 amino acids; 28002 Da

Explore the universe of human proteins at neXtProt for CTRL: NX_P40313

Explore proteomics data for CTRL at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn114
  • Selected DME Specific Peptides for CTRL (P40313) (see all 7)
     FCGGSLI  GDSGGPL  WPWQVSL  HFCGGSL 


    See CTRL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001898.1  
    ENSEMBL proteins: 
     ENSP00000458537   ENSP00000461842   ENSP00000458598  

    CTRL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CTRL
    OriGene Protein Over-expression Lysate for CTRL
    OriGene MassSpec for CTRL
    OriGene Custom Protein Services for CTRL
    GenScript Custom Purified and Recombinant Proteins Services for CTRL
    Novus Biologicals CTRL Protein
    Novus Biologicals CTRL Lysate
    Sino Biological Recombinant Protein for CTRL
    Sino Biological Cell Lysate for CTRL
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTRL

     
    Search eBioscience for Proteins for CTRL 

     
    antibodies-online proteins for CTRL (11 products) 

     
    antibodies-online peptides for CTRL

    CTRL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CTRL
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CTRL
    Novus Biologicals CTRL Antibodies
    Abcam antibodies for CTRL
    Cloud-Clone Corp. Antibodies for CTRL
    Search ThermoFisher Antibodies for CTRL
    antibodies-online antibodies for CTRL (68 products) 

    CTRL Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CTRL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CTRL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CTRL
    Cloud-Clone Corp. CLIAs for CTRL
    Search eBioscience for ELISAs for CTRL 
    antibodies-online kits for CTRL (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P40313

    ProtoNet protein and cluster: P40313

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: CTRL_HUMAN, P40313
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with CTRL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for CTRL:
    chymotrypsin protease-like,pancreas

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008233peptidase activity ----
    GO:0008236serine-type peptidase activity ----
         
    Find genes that share ontologies with CTRL           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CTRL

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CTRL using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CTRL:
    hsa-miR-4328 hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidCTRL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CTRL
    Predesigned siRNA for gene silencing in human, mouse, rat CTRL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CTRL

    Clone
    Products:
         
    OriGene clones in human, mouse for CTRL (see all 6)
    OriGene ORF clones in mouse, rat for CTRL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTRL (NM_001907)
    Sino Biological Human cDNA Clone for CTRL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRL

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CTRL
    Browse ESI BIO Cell Lines and PureStem Progenitors for CTRL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTRL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytosol2
    lysosome2
    nucleus2
    vacuole2
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS9065485

    Find genes that share ontologies with CTRL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTRL About    
    See pathways by source

    SuperPathContained pathways About
    1Protein digestion and absorption
    Protein digestion and absorption
    2Pancreatic secretion
    Pancreatic secretion


    Find genes that share SuperPaths with CTRL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for CTRL):
        Pancreatic secretion
    Protein digestion and absorption

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTRL
    Interactions:

        GeneGlobe Interaction Network for CTRL

    2 Interacting proteins for CTRL (P403132, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ING1Q9UK532, 3MINT-6616081 I2D: score=1 
    SERPINA3P010113I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS9065485
    GO:0007586digestion TAS9065485

    Find genes that share ontologies with CTRL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTRL

    Selected Novoseek inferred chemical compound relationships for CTRL gene (see all 58)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zlyck 82.5 4 1874738 (1), 1653805 (1)
    chymostatin 81.9 6 11112426 (1), 8031148 (1), 8022661 (1), 8458433 (1) (see all 6)
    clasto-lactacystinbeta-lactone 77.7 2 9601040 (1), 16719460 (1)
    3,4-dichloroisocoumarin 74.3 4 1356435 (1), 8431436 (1)
    tpck 73.4 8 9178191 (2), 11112426 (1), 19653099 (1), 15197350 (1) (see all 6)
    lactacystin 73.3 9 10856705 (1), 16941495 (1), 17140599 (1), 12146975 (1)
    bortezomib 71.6 14 18502982 (2), 19946334 (2), 19020781 (1), 17616698 (1) (see all 6)
    serine 71.2 36 8363563 (1), 11708923 (1), 15654079 (1), 19281249 (1) (see all 34)
    n-acetyl-leu-leu-methioninal 67.4 1 8431436 (1)
    mg 132 67.3 2 18565852 (1), 17352013 (1)



    Find genes that share compounds with CTRL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTRL gene: 
    NM_001907.2  

    Unigene Cluster for CTRL:

    Chymotrypsin-like
    Hs.654546  [show with all ESTs]
    Unigene Representative Sequence: BM918604
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000573845 ENST00000574481(uc002euw.3) ENST00000572144 ENST00000576915
    ENST00000571044 ENST00000571605 ENST00000576408 ENST00000575302
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CTRL using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CTRL:
    hsa-miR-4328 hsa-miR-143*
    SwitchGear 3'UTR luciferase reporter plasmidCTRL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CTRL
    Predesigned siRNA for gene silencing in human, mouse, rat CTRL
    Clone
    Products:
         
    OriGene clones in human, mouse for CTRL (see all 6)
    OriGene ORF clones in mouse, rat for CTRL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTRL (NM_001907)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRL
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CTRL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTRL
      QuantiTect SYBR Green Assays in human, mouse, rat CTRL
      QuantiFast Probe-based Assays in human, mouse, rat CTRL

    Additional mRNA sequence: 

    AK223172.1 BC039716.1 BC063475.1 X71877.1 

    5 DOTS entries:

    DT.441944  DT.97796543  DT.120704986  DT.100796135  DT.86840959 

    Selected AceView cDNA sequences (see all 282):

    BI768280 BM919492 BI832541 CD366330 AL524229 AI123588 BE466922 BM919400 
    NM_001907 BI834199 BP432229 BU689482 BI766620 CR597889 AW004684 BM832240 
    BQ673598 AW451221 CB852964 BU074473 CD365722 BG392300 AW075764 BQ901169 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CTRL (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^
    SP1:                                      -     -                       -     -                                                                                 
    SP2:                                                                                                              -                                   -         
    SP3:                                                                                                              -     -           -                           
    SP4:                                      -     -                                                                                                               
    SP5:                                      -     -                                                                                                               

    ExUns: 15 ^ 16a · 16b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for CTRL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTRL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGAGGCCGG
    CTRL Expression
    About this image


    CTRL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
    CTRL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTRL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654546
        Custom PCR Arrays for CTRL
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CTRL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTRL
    QuantiTect SYBR Green Assays in human, mouse, rat CTRL
    QuantiFast Probe-based Assays in human, mouse, rat CTRL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTRL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CTRL gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctrl1 , 5 chymotrypsin-like1, 5 84.01(n)1
    85.48(a)1
      8 (53.06 cM)5
    1096601  NM_023182.21  NP_075671.11 
     1059319945 
    chicken
    (Gallus gallus)
    Aves CTRL1 chymotrypsin-like 70.07(n)
    66.53(a)
      427531  NM_001277625.1  NP_001264554.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTRL6
    chymotrypsin-like
    72(a)
    1 ↔ 1
    GL343295.1(474128-489379)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.49302 Transcribed sequence with weak similarity to protein more 76.15(n)    CF594751.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG118363 serine-type endopeptidase 39(a)
    (best of 8)
      96B20   --


    ENSEMBL Gene Tree for CTRL (if available)
    TreeFam Gene Tree for CTRL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTRL gene
    CTRC2  CELA2A2  CELA3B2  CTRB12  CELA12  CELA3A2  CELA2B2  CTRB22  
    Selected SIMAP similar genes for CTRL using alignment to 4 protein entries:     CTRL_HUMAN (see all proteins) (see all similar genes):
    FLJ00366    CTRB1    CTRB2    TMPRSS3    DKFZp586F0824    CELA2B
    PRSS42    CELA2A    ELA2A    CELA1    CELA3B    KLKB1
    OVCH1    KLK11    ELA2B    HPN    F11    KLK7

    Find genes that share paralogs with CTRL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTRL (see all 119)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2019113331,2
    --67964114(+) GCCACC/GTGCAC 2 R G mis10--------
    rs2010734851,2
    C--67964119(+) CTGCAC/TAGATC 2 Y C mis10--------
    rs11347601,2,,4
    C,F,H--67964203(+) GCAGAT/CGTGCT 2 /H /R mis121Minor allele frequency- C:0.24EA NA NS WA CSA EU 8160
    rs743369931,2
    C,F--67964238(+) GAGGGG/TTGGTC 1 -- int15Minor allele frequency- T:0.01CSA WA EU 1388
    rs2001209721,2
    --67964325(+) TGAGGC/TGACCC 2 H R mis10--------
    rs1476363331,2
    C,F--67964349(+) CACACG/ATGAGG 2 /T /M mis11Minor allele frequency- A:0.00NA 4544
    rs1396709851,2
    C,F--67964359(+) GCCTTC/GAGTCA 2 Q E mis11Minor allele frequency- G:0.00NA 4550
    rs115529531,2,,4
    C,F,H--67964361(+) CTTCAG/ATCAGA 2 /T /I mis1 ese312Minor allele frequency- A:0.05NS NA WA EU 7033
    rs2017739391,2
    --67964375(+) TCGTTG/TGAGGA 2 S syn10--------
    rs2009446181,2
    --67964428(+) CGAGGC/TGAGCT 2 T A mis10--------

    HapMap Linkage Disequilibrium report for CTRL (67961543 - 67966317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CTRL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524363CNV Loss19592680
    nsv522852CNV Gain19592680

    Human Gene Mutation Database (HGMD): CTRL
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTRL
    DNA2.0 Custom Variant and Variant Library Synthesis for CTRL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118888    OMIM disorders: --

    5 diseases for CTRL:    
    About MalaCards
    severe acute respiratory syndrome    netherton syndrome    lymphoblastic lymphoma    newcastle disease
    hepatitis a

    2 diseases from the University of Copenhagen DISEASES database for CTRL:
    Severe acute respiratory syndrome     Multiple myeloma

    Find genes that share disorders with CTRL           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CTRL gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    netherton syndrome 57.7 1 16628198 (1)
    prostate cancer 40.4 10 17541980 (2), 16651429 (1), 17308104 (1), 18304598 (1) (see all 8)
    tumors 28.9 13 10894830 (1), 12460905 (1), 7957109 (1), 19671918 (1) (see all 12)
    cancer 28.2 7 20514399 (2), 16455650 (1), 17982703 (1), 17541980 (1) (see all 5)
    leukemia 26.7 3 14960234 (1), 15066131 (1), 18773885 (1)
    alzheimers disease 19.9 2 10386971 (1), 8336143 (1)
    breast cancer 17.7 5 15746161 (1), 19337512 (1), 19911377 (1), 16806088 (1) (see all 5)
    metastasis 3.55 1 10894830 (1)
    necrosis 0 1 7957109 (1)
    cataract 0 5 17162884 (3)


    Export disorders for CTRL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTRL gene, integrated from 10 sources (see all 232):
    (articles sorted by number of sources associating them with CTRL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A tight cluster of five unrelated human genes on chromosome 16q22.1. (PubMed id 8268911)1, 2, 3, 9 Larsen F.... Prydz H. (Hum. Mol. Genet. 1993)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsia. (PubMed id 19126871)1, 9 Gu Y....Wang Y. (Reprod Sci 2009)
    4. Chymotrypsin-like protease (chymase) mediates endothelial activation by factors derived from preeclamptic placentas. (PubMed id 19494363)1, 9 Yang Gu ....Yuping Wang . (Reprod Sci 2009)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    6. Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux. (PubMed id 12231569)1 Lee M....Kovanen P.T. (Arterioscler. Thromb. Vasc. Biol. 2002)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. A novel human chymotrypsin-like digestive enzyme. (PubMed id 9065485)1 Reseland J.E....Prydz H. (J. Biol. Chem. 1997)
    9. Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3). (PubMed id 8812482)1 Mastroianni N.... Casari G. (Genomics 1996)
    10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1506 HGNC: 2524 AceView: CTRLandPSMB10 Ensembl:ENSG00000141086 euGenes: HUgn1506
    ECgene: CTRL Kegg: 1506 H-InvDB: CTRL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CTRL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CTRL gene:
    Search GeneIP for patents involving CTRL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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