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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTRL Gene

protein-coding   GIFtS: 60
GCID: GC16M067963

Chymotrypsin-Like

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
chymotrypsin-like1 2
CTRL12 3
Chymotrypsin-Like Protease CTRL-12
EC 3.4.21.-3
EC 3.4.218

External Ids:    HGNC: 25241   Entrez Gene: 15062   Ensembl: ENSG000001410867   OMIM: 1188885   UniProtKB: P403133   

Export aliases for CTRL gene to outside databases

Previous GC identifers: GC16M058658 GC16M068341 GC16M067698 GC16M067740 GC16M067741 GC16M066521 GC16M053837


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CTRL Gene: 
CTRL (chymotrypsin-like) is a protein-coding gene. Diseases associated with CTRL include jmp syndrome, and lymphoblastic lymphoma. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CTRC.

Gene Wiki entry for CTRL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTRL gene promoter:
         GR   p53   COMP1   GR-beta   GR-alpha   LCR-F1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTRL promoter sequence
   Search SABiosciences Chromatin IP Primers for CTRL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTRL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

CTRL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTRL gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M067963:  view genomic region     (about GC identifiers)

Start:
67,961,543 bp from pter      End:
67,966,317 bp from pter
Size:
4,775 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CTRL_HUMAN, P40313 (See protein sequence)
Recommended Name: Chymotrypsin-like protease CTRL-1 precursor  
Size: 264 amino acids; 28002 Da

Explore the universe of human proteins at neXtProt for CTRL: NX_P40313

4/7 DME Specific Peptides for CTRL (P40313) (see all 7)
 FCGGSLI  GDSGGPL  WPWQVSL  HFCGGSL 

CTRL Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
REFSEQ proteins: NP_001898.1  
ENSEMBL proteins: 
 ENSP00000458537   ENSP00000461842   ENSP00000458598  

Human Recombinant Protein Products for CTRL: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for CTRL
OriGene Protein Over-expression Lysate for CTRL
OriGene MassSpec for CTRL 
OriGene Custom Protein Services for CTRL
GenScript Custom Purified and Recombinant Proteins Services for CTRL
Novus Biologicals CTRL Protein
Novus Biologicals CTRL Lysate
Sino Biological Recombinant Protein for CTRL
Sino Biological Cell Lysate for CTRL 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for CTRL 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space TAS9065485

CTRL for ontologies           About GeneDecksing



CTRL Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of CTRL
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for CTRL
GenScript Custom Superior Antibodies Services for CTRL
Novus Biologicals CTRL Antibodies
Abcam antibodies for CTRL
Cloud-Clone Corp. Antibodies for CTRL 
Search ThermoFisher Antibodies for CTRL
LSBio Antibodies in human, mouse, rat for CTRL 

Assay Products for CTRL: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CTRL
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CTRL
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for CTRL 
Cloud-Clone Corp. CLIAs for CTRL


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR001314 Peptidase_S1A
 IPR001254 Peptidase_S1
 IPR018114 Peptidase_S1_AS
 IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry P40313

ProtoNet protein and cluster: P40313

2 Blocks protein domains:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: CTRL_HUMAN, P40313
Similarity: Belongs to the peptidase S1 family
Similarity: Contains 1 peptidase S1 domain


CTRL for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for CTRL:
chymotrypsin protease-like,pancreas

     Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.-1

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004252serine-type endopeptidase activity IEA--
GO:0008233peptidase activity ----
     
CTRL for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CTRL 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTRL

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTRL 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTRL 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTRL
2 QIAGEN miScript miRNA Assays for microRNAs that regulate CTRL:
hsa-miR-4328 hsa-miR-143*
SwitchGear 3'UTR luciferase reporter plasmidCTRL 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CTRL
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTRL

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CTRL
Sirion Biotech Customized adenovirus for overexpression of CTRL

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for CTRL (see all 6)
OriGene ORF clones in mouse, rat for CTRL
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CTRL (NM_001907)
Sino Biological Human cDNA Clone for CTRL
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRL
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRL
Sirion Biotech Customized lentivirus for stable overexpression of CTRL 
                     Customized lentivirus expression plasmids for stable overexpression of CTRL 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CTRL
Search LifeMap BioReagents cell lines for CTRL
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTRL


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CTRL About                                                                                                See pathways by source

SuperPathContained pathways About
1Protein digestion and absorption
Protein digestion and absorption
2Pancreatic secretion
Pancreatic secretion

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways




2         Kegg Pathways  (Kegg details for CTRL):
    Pancreatic secretion
Protein digestion and absorption


CTRL for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTRL

2 Interacting proteins for CTRL (P403132, 3) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ING1Q9UK532, 3MINT-6616081 I2D: score=1 
SERPINA3P010113I2D: score=2 
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--
GO:0007586digestion TAS9065485

CTRL for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CTRL for compounds           About GeneDecksing

EMD Millipore small molecules for CTRL:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CTRL

10/58 Novoseek inferred chemical compound relationships for CTRL gene (see all 58)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
zlyck 82.5 4 1874738 (1), 1653805 (1)
chymostatin 81.9 6 11112426 (1), 8031148 (1), 8022661 (1), 8458433 (1) (see all 6)
clasto-lactacystinbeta-lactone 77.7 2 9601040 (1), 16719460 (1)
3,4-dichloroisocoumarin 74.3 4 1356435 (1), 8431436 (1)
tpck 73.4 8 9178191 (2), 11112426 (1), 19653099 (1), 15197350 (1) (see all 6)
lactacystin 73.3 9 10856705 (1), 16941495 (1), 17140599 (1), 12146975 (1)
bortezomib 71.6 14 18502982 (2), 19946334 (2), 19020781 (1), 17616698 (1) (see all 6)
serine 71.2 36 8363563 (1), 11708923 (1), 15654079 (1), 19281249 (1) (see all 34)
n-acetyl-leu-leu-methioninal 67.4 1 8431436 (1)
mg 132 67.3 2 18565852 (1), 17352013 (1)

Search CenterWatch for drugs/clinical trials and news about CTRL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CTRL gene: 
NM_001907.2  

Unigene Cluster for CTRL:

Chymotrypsin-like
Hs.654546  [show with all ESTs]
Unigene Representative Sequence: BM918604
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000573845 ENST00000574481(uc002euw.3) ENST00000572144 ENST00000576915
ENST00000571044 ENST00000571605 ENST00000576408 ENST00000575302
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTRL
2 QIAGEN miScript miRNA Assays for microRNAs that regulate CTRL:
hsa-miR-4328 hsa-miR-143*
SwitchGear 3'UTR luciferase reporter plasmidCTRL 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CTRL
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTRL
Clone
Products:
     
OriGene clones in human, mouse for CTRL (see all 6)
OriGene ORF clones in mouse, rat for CTRL
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CTRL (NM_001907)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRL
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRL
Sirion Biotech Customized lentivirus for stable overexpression of CTRL 
                     Customized lentivirus expression plasmids for stable overexpression of CTRL 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for CTRL
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTRL
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTRL
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTRL

Additional mRNA sequence: 

AK223172.1 BC039716.1 BC063475.1 X71877.1 

5 DOTS entries:

DT.441944  DT.97796543  DT.120704986  DT.100796135  DT.86840959 

24/282 AceView cDNA sequences (see all 282):

BU624134 BQ058569 AI342523 AI123588 BC052369 AJ711614 BM919892 CB241116 
AI338861 BQ051539 BI766620 BM781750 AA746280 BC063475 AW075764 AA587209 
BM979701 CA748523 BF925687 AJ573626 BF913957 BI833975 AW270020 CD672576 

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CTRL (see all 12)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^
SP1:                                      -     -                       -     -                                                                                 
SP2:                                                                                                              -                                   -         
SP3:                                                                                                              -     -           -                           
SP4:                                      -     -                                                                                                               
SP5:                                      -     -                                                                                                               

ExUns: 15 ^ 16a · 16b
SP1:                  
SP2:                  
SP3:                  
SP4:                  
SP5:                  


ECgene alternative splicing isoforms for CTRL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CTRL expression in normal human tissues (normalized intensities)      CTRL embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCGAGGCCGG
CTRL Expression
About this image


CTRL expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Pancreas (Endocrine System)    fully expand to see all 3 entries
         Duct Cells Pancreatic Ducts
         Pancreatic Islet   
 
 Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
         neonatal small intestine   

Genevestigator expression for CTRL

SOURCE GeneReport for Unigene cluster: Hs.654546
    SABiosciences Custom PCR Arrays for CTRL
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for CTRL
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTRL
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTRL
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTRL
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTRL

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CTRL gene from 5/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ctrl1 , 5 chymotrypsin-like1, 5 84.22(n)1
86.36(a)1
  8 (53.06 cM)5
1096601  NM_023182.21  NP_075671.11 
 1059319945 
chicken
(Gallus gallus)
Aves CTRL1 chymotrypsin-like 68.58(n)
64.12(a)
  427531  XM_425105.3  XP_425105.1 
lizard
(Anolis carolinensis)
Reptilia CTRL6
Uncharacterized protein
72(a)
1 ↔ 1
GL343295.1(474128-489379)
zebrafish
(Danio rerio)
Actinopterygii Dr.49302 Transcribed sequence with weak similarity to protein more 76.15(n)    CF594751.1 
fruit fly
(Drosophila melanogaster)
Insecta CG118363
CG317281
serine-type endopeptidase3
CG317281
39(a)
(best of 8)3
48.26(n)1
39.57(a)1
  96B203
347311  NM_165031.31  NP_723797.31 


ENSEMBL Gene Tree for CTRL (if available)
TreeFam Gene Tree for CTRL (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CTRL gene
CTRC2  CELA2A2  CELA3B2  CELA12  CTRB12  CELA3A2  CELA2B2  OVCH22  
CTRB22  OVCH12  
18/115 SIMAP similar genes for CTRL using alignment to 4 protein entries:     CTRL_HUMAN (see all proteins) (see all similar genes):
FLJ00366    CTRB1    CTRB2    TMPRSS3    DKFZp586F0824    CELA2B
PRSS42    CELA2A    ELA2A    CELA1    CELA3B    KLKB1
OVCH1    KLK11    ELA2B    HPN    F11    KLK7

CTRL for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/119 SNPs in CTRL are shown (see all 119)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2019113331,2
--67964114(+) GCCACC/GTGCAC 2 R G mis10--------
rs2010734851,2
C--67964119(+) CTGCAC/TAGATC 2 Y C mis10--------
rs11347601,2,4
C,F,H--67964203(+) GCAGAT/CGTGCT 2 /H /R mis121Minor allele frequency- C:0.24EA NA NS WA CSA EU 8160
rs743369931,2
C,F--67964238(+) GAGGGG/TTGGTC 1 -- int15Minor allele frequency- T:0.01CSA WA EU 1388
rs2001209721,2
--67964325(+) TGAGGC/TGACCC 2 H R mis10--------
rs1476363331,2
C,F--67964349(+) CACACG/ATGAGG 2 /T /M mis11Minor allele frequency- A:0.00NA 4544
rs1396709851,2
C,F--67964359(+) GCCTTC/GAGTCA 2 Q E mis11Minor allele frequency- G:0.00NA 4550
rs115529531,2,4
C,F,H--67964361(+) CTTCAG/ATCAGA 2 /T /I mis1 ese312Minor allele frequency- A:0.05NS NA WA EU 7033
rs2017739391,2
--67964375(+) TCGTTG/TGAGGA 2 S syn10--------
rs2009446181,2
--67964428(+) CGAGGC/TGAGCT 2 T A mis10--------

HapMap Linkage Disequilibrium report for CTRL (67961543 - 67966317 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for CTRL:    About this table     
Variant IDTypeSubtypePubMed ID
nsv524363CNV Loss19592680
nsv522852CNV Gain19592680


Human Gene Mutation Database (HGMD): CTRL
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CTRL
DNA2.0 Custom Variant and Variant Library Synthesis for CTRL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 118888    OMIM disorders: --

20/35 diseases for CTRL (see all 35):    About MalaCards
jmp syndrome    lymphoblastic lymphoma    newcastle disease    balanitis
severe acute respiratory syndrome    netherton syndrome    chronic leukemia    mouth disease
hepatitis a    vaginitis    duodenitis    cataract
gingivitis    encephalomyelitis    gastric cancer    acute myeloid leukemia
alzheimer's disease    periodontitis    prostate cancer    myeloma

2 diseases from the University of Copenhagen DISEASES database for CTRL:
Severe acute respiratory syndrome     Multiple myeloma

CTRL for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/14 Novoseek inferred disease relationships for CTRL gene (see all 14)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
netherton syndrome 57.7 1 16628198 (1)
prostate cancer 40.4 10 17541980 (2), 16651429 (1), 17308104 (1), 18304598 (1) (see all 8)
tumors 28.9 13 10894830 (1), 12460905 (1), 7957109 (1), 19671918 (1) (see all 12)
cancer 28.2 7 20514399 (2), 16455650 (1), 17982703 (1), 17541980 (1) (see all 5)
leukemia 26.7 3 14960234 (1), 15066131 (1), 18773885 (1)
alzheimers disease 19.9 2 10386971 (1), 8336143 (1)
breast cancer 17.7 5 15746161 (1), 19337512 (1), 19911377 (1), 16806088 (1) (see all 5)
metastasis 3.55 1 10894830 (1)
necrosis 0 1 7957109 (1)
cataract 0 5 17162884 (3)


Export disorders for CTRL gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CTRL gene, integrated from 9 sources (see all 232):
(articles sorted by number of sources associating them with CTRL)
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  1. A tight cluster of five unrelated human genes on chromosome 16q22.1. (PubMed id 8268911)1, 2, 3, 9 Larsen F.... Prydz H. (1993)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsia. (PubMed id 19126871)1, 9 Gu Y....Wang Y. (2009)
  4. Chymotrypsin-like protease (chymase) mediates endothe lial activation by factors derived from preeclamptic placentas. (PubMed id 19494363)1, 9 Yang Gu ....Yuping Wang . (2009)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  6. Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux. (PubMed id 12231569)1 Lee M....Kovanen P.T. (2002)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. A novel human chymotrypsin-like digestive enzyme. (PubMed id 9065485)1 Reseland J.E....Prydz H. (1997)
  9. Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3). (PubMed id 8812482)1 Mastroianni N.... Casari G. (1996)
  10. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1506 HGNC: 2524 AceView: CTRLandPSMB10 Ensembl:ENSG00000141086 euGenes: HUgn1506
ECgene: CTRL Kegg: 1506 H-InvDB: CTRL

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CTRL Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CTRL gene:
Search GeneIP for patents involving CTRL

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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