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Aliases for CTRL Gene

Aliases for CTRL Gene

  • Chymotrypsin Like 2 3
  • Chymotrypsin-Like 2 3 5
  • CTRL1 3 4
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for CTRL Gene

Previous GeneCards Identifiers for CTRL Gene

  • GC16M058658
  • GC16M068341
  • GC16M067698
  • GC16M067740
  • GC16M067741
  • GC16M066521
  • GC16M067963
  • GC16M053837

Summaries for CTRL Gene

GeneCards Summary for CTRL Gene

CTRL (Chymotrypsin Like) is a Protein Coding gene. Diseases associated with CTRL include netherton syndrome and newcastle disease. Among its related pathways are Protein digestion and absorption and Pancreatic secretion. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is CELA2B.

Gene Wiki entry for CTRL Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTRL Gene

Genomics for CTRL Gene

Regulatory Elements for CTRL Gene

Genomic Location for CTRL Gene

Chromosome:
16
Start:
67,927,640 bp from pter
End:
67,932,414 bp from pter
Size:
4,775 bases
Orientation:
Minus strand

Genomic View for CTRL Gene

Genes around CTRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTRL Gene

Proteins for CTRL Gene

  • Protein details for CTRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40313-CTRL_HUMAN
    Recommended name:
    Chymotrypsin-like protease CTRL-1
    Protein Accession:
    P40313

    Protein attributes for CTRL Gene

    Size:
    264 amino acids
    Molecular mass:
    28002 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTRL Gene

Proteomics data for CTRL Gene at MOPED

Selected DME Specific Peptides for CTRL Gene

Post-translational modifications for CTRL Gene

  • Glycosylation at Asn 114
  • Modification sites at PhosphoSitePlus

Other Protein References for CTRL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for CTRL Gene

Suggested Antigen Peptide Sequences for CTRL Gene

Graphical View of Domain Structure for InterPro Entry

P40313

UniProtKB/Swiss-Prot:

CTRL_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CTRL: view

No data available for Gene Families for CTRL Gene

Function for CTRL Gene

Molecular function for CTRL Gene

GENATLAS Biochemistry:
chymotrypsin protease-like,pancreas

Enzyme Numbers (IUBMB) for CTRL Gene

genes like me logo Genes that share phenotypes with CTRL: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CTRL Gene

Localization for CTRL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTRL Gene COMPARTMENTS Subcellular localization image for CTRL gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
lysosome 2
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CTRL Gene

Pathways & Interactions for CTRL Gene

genes like me logo Genes that share pathways with CTRL: view

Pathways by source for CTRL Gene

Gene Ontology (GO) - Biological Process for CTRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007586 digestion TAS 9065485
genes like me logo Genes that share ontologies with CTRL: view

No data available for SIGNOR curated interactions for CTRL Gene

Drugs & Compounds for CTRL Gene

(37) Drugs for CTRL Gene - From: Novoseek and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AM 114 Pharma 20S proteasome inhibitor 0
Bortezomib (PS-341) Pharma Proteasome Inhibitor 0
Carfilzomib (PR-171) Pharma Proteasome inhibitor,epoxomicin analog 0
CEP-18770 Pharma Proteasome inhibitor 0
MLN9708 Pharma Proteasome inhibitor, 20S Proteasome Inhibitor 0

(27) Additional Compounds for CTRL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(6) ApexBio Compounds for CTRL Gene

Compound Action Cas Number
AM 114 20S proteasome inhibitor 856849-35-9
Bortezomib (PS-341) Proteasome Inhibitor 179324-69-7
Carfilzomib (PR-171) Proteasome inhibitor,epoxomicin analog 868540-17-4
CEP-18770 Proteasome inhibitor 847499-27-8
MLN9708 Proteasome inhibitor 1201902-80-8
PI-1840 Chymotrypsin-like (CT-L) inhibitor 1401223-22-0
genes like me logo Genes that share compounds with CTRL: view

Transcripts for CTRL Gene

Unigene Clusters for CTRL Gene

Chymotrypsin-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTRL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^
SP1: - - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - -
SP6: - -
SP7: -
SP8:
SP9: - -
SP10: - -
SP11:
SP12:

ExUns: 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CTRL Gene

GeneLoc Exon Structure for
CTRL
ECgene alternative splicing isoforms for
CTRL

Expression for CTRL Gene

mRNA expression in normal human tissues for CTRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTRL Gene

This gene is overexpressed in Pancreas (x49.0).

Protein differential expression in normal tissues from HIPED for CTRL Gene

This gene is overexpressed in Pancreatic juice (62.9) and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTRL Gene



SOURCE GeneReport for Unigene cluster for CTRL Gene Hs.654546

genes like me logo Genes that share expression patterns with CTRL: view

Protein tissue co-expression partners for CTRL Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CTRL Gene

Orthologs for CTRL Gene

This gene was present in the common ancestor of animals.

Orthologs for CTRL Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CTRL 35
  • 88.04 (n)
  • 88.31 (a)
CTRL 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctrl 35
  • 84.01 (n)
  • 85.48 (a)
Ctrl 16
Ctrl 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTRL 35
  • 99.37 (n)
  • 98.48 (a)
CTRL 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctrl 35
  • 84.95 (n)
  • 86.69 (a)
cow
(Bos Taurus)
Mammalia CTRB1 36
  • 54 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia CTRL 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTRL 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTRL 35
  • 70.07 (n)
  • 66.53 (a)
lizard
(Anolis carolinensis)
Reptilia CTRL 36
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ctrl 35
  • 65.17 (n)
  • 65.31 (a)
Dr.4930 35
ctrl 36
  • 62 (a)
OneToMany
CTRL (1 of 3) 36
  • 56 (a)
OneToMany
CTRL (3 of 3) 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD13269 37
  • 34 (a)
CG11824 37
  • 39 (a)
CG11836 37
  • 39 (a)
CG6467 37
  • 38 (a)
CG6483 37
  • 35 (a)
CG7542 37
  • 34 (a)
mas 37
  • 36 (a)
Sb 37
  • 37 (a)
CG10469 36
  • 31 (a)
ManyToMany
CG10472 36
  • 29 (a)
ManyToMany
CG10477 36
  • 31 (a)
ManyToMany
CG11529 36
  • 26 (a)
ManyToMany
CG18179 36
  • 26 (a)
ManyToMany
CG18180 36
  • 27 (a)
ManyToMany
CG3088 36
  • 24 (a)
ManyToMany
CG6462 36
  • 26 (a)
ManyToMany
CG6592 36
  • 19 (a)
ManyToMany
CG7542 36
  • 34 (a)
ManyToMany
CG8329 36
  • 25 (a)
ManyToMany
CG8952 36
  • 31 (a)
ManyToMany
Jon25Bi 36
  • 27 (a)
ManyToMany
Jon25Bii 36
  • 29 (a)
ManyToMany
Jon25Biii 36
  • 29 (a)
ManyToMany
Jon44E 36
  • 33 (a)
ManyToMany
Jon65Ai 36
  • 28 (a)
ManyToMany
Jon65Aii 36
  • 27 (a)
ManyToMany
Jon65Aiii 36
  • 31 (a)
ManyToMany
Jon65Aiv 36
  • 33 (a)
ManyToMany
Jon66Ci 36
  • 29 (a)
ManyToMany
Jon66Cii 36
  • 29 (a)
ManyToMany
Jon74E 36
  • 19 (a)
ManyToMany
Jon99Ci 36
  • 28 (a)
ManyToMany
Jon99Cii 36
  • 31 (a)
ManyToMany
Jon99Ciii 36
  • 31 (a)
ManyToMany
Jon99Fi 36
  • 30 (a)
ManyToMany
Jon99Fii 36
  • 30 (a)
ManyToMany
sphinx1 36
  • 20 (a)
ManyToMany
sphinx2 36
  • 22 (a)
ManyToMany
yip7 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
ManyToMany
Species with no ortholog for CTRL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTRL Gene

ENSEMBL:
Gene Tree for CTRL (if available)
TreeFam:
Gene Tree for CTRL (if available)

Paralogs for CTRL Gene

Paralogs for CTRL Gene

genes like me logo Genes that share paralogs with CTRL: view

Variants for CTRL Gene

Sequence variations from dbSNP and Humsavar for CTRL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1134760 - 67,930,300(+) GCAGA(C/T)GTGCT reference, missense
rs11552953 - 67,930,458(+) CTTCA(A/G)TCAGA reference, missense
rs1079724 -- 67,931,689(-) GTGGG(C/T)AAAAG intron-variant
rs1079725 -- 67,931,647(-) AACAG(G/T)CCTGC intron-variant
rs1079726 -- 67,931,031(-) GCCCA(C/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTRL Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680

Variation tolerance for CTRL Gene

Residual Variation Intolerance Score: 86.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.25; 85.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTRL Gene

HapMap Linkage Disequilibrium report
CTRL
Human Gene Mutation Database (HGMD)
CTRL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTRL Gene

Disorders for CTRL Gene

MalaCards: The human disease database

(2) MalaCards diseases for CTRL Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
netherton syndrome
  • n syndrome
newcastle disease
  • newcastle disease [ambiguous]
- elite association - COSMIC cancer census association via MalaCards
Search CTRL in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTRL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTRL
genes like me logo Genes that share disorders with CTRL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTRL Gene

Publications for CTRL Gene

  1. A tight cluster of five unrelated human genes on chromosome 16q22.1. (PMID: 8268911) Larsen F. … Prydz H. (Hum. Mol. Genet. 1993) 2 3 4 23 67
  2. Placenta-derived chymotrypsin-like protease (CLP) disturbs endothelial junctional structure in preeclampsia. (PMID: 19126871) Gu Y. … Wang Y. (Reprod Sci 2009) 3 23
  3. Chymotrypsin-like protease (chymase) mediates endothelial activation by factors derived from preeclamptic placentas. (PMID: 19494363) Yang Gu . … Yuping Wang . (Reprod Sci 2009) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3

Products for CTRL Gene

Sources for CTRL Gene

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