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CTRC Gene

protein-coding   GIFtS: 61
GCID: GC01P015764

Chymotrypsin C (Caldecrin)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chymotrypsin C (Caldecrin)1 2     Elastase IV2
CLCR2 3 5     Serum Calcium Decreasing Factor2
Elastase 41 2     Caldecrin3
ELA42     EC 3.4.21.23
caldecrin2     EC 3.4.218
chymotrypsin-C2     

External Ids:    HGNC: 25231   Entrez Gene: 113302   Ensembl: ENSG000001624387   OMIM: 6014055   UniProtKB: Q998953   

Export aliases for CTRC gene to outside databases

Previous GC identifers: GC01P015162 GC01P014943 GC01P015033 GC01P015127 GC01P015510 GC01P015637 GC01P014284


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTRC Gene:
This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor
that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but
their full-length nature has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CTRC Gene:
CTRC (chymotrypsin C (caldecrin)) is a protein-coding gene. Diseases associated with CTRC include pancreatitis, chronic, and ctrc-related hereditary pancreatitis. GO annotations related to this gene include peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is CTRL.

UniProtKB/Swiss-Prot: CTRC_HUMAN, Q99895
Function: Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific
cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity

Gene Wiki entry for CTRC (Chymotrypsin-C) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTRC gene promoter:
         HOXA3   Nkx5-1   LCR-F1   Tal-1beta   YY1   HFH-1   Msx-1   LyF-1   ITF-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTRC promoter sequence
   Search Chromatin IP Primers for CTRC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTRC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.21

CTRC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTRC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P015764:  view genomic region     (about GC identifiers)

Start:
15,764,935 bp from pter      End:
15,775,737 bp from pter
Size:
10,803 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTRC_HUMAN, Q99895 (See protein sequence)
Recommended Name: Chymotrypsin-C precursor  
Size: 268 amino acids; 29484 Da
1 PDB 3D structure from and Proteopedia for CTRC:
4H4F (3D)    
Secondary accessions: A8K082 O00765 Q9NUH5

Explore the universe of human proteins at neXtProt for CTRC: NX_Q99895

Explore proteomics data for CTRC at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn25, Asn52, Asn226
  • Selected DME Specific Peptides for CTRC (Q99895) (see all 5)
     GDSGGPL  DIALIKL  TRVSAYI  VLTAAHC 


    See CTRC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009203.2  
    ENSEMBL proteins: 
     ENSP00000365116   ENSP00000365110  

    CTRC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CTRC (Chymotrypsin C/CTRC)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CTRC
    OriGene Protein Over-expression Lysate for CTRC
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CTRC
    GenScript Custom Purified and Recombinant Proteins Services for CTRC
    Novus Biologicals CTRC Proteins
    Novus Biologicals CTRC Lysates
    Sino Biological Recombinant Protein for CTRC
    Sino Biological Cell Lysate for CTRC
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CTRC Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CTRC (Chymotrypsin C/CTRC)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CTRC
    Novus Biologicals CTRC Antibodies
    Abcam antibodies for CTRC
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CTRC
    LSBio Antibodies in human, mouse, rat for CTRC

    CTRC Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CTRC
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q99895

    ProtoNet protein and cluster: Q99895

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: CTRC_HUMAN, Q99895
    Similarity: Belongs to the peptidase S1 family. Elastase subfamily
    Similarity: Contains 1 peptidase S1 domain


    CTRC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTRC_HUMAN, Q99895
    Function: Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific
    cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity
    Catalytic activity: Preferential cleavage: Leu- -Xaa, Tyr- -Xaa, Phe- -Xaa, Met- -Xaa, Trp- -Xaa, Gln- -Xaa, Asn-
    -Xaa

         Enzyme Numbers (IUBMB): EC 3.4.21.21 EC 3.4.212

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0008233peptidase activity TAS8635596
         
    CTRC for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CTRC:
     Decreased TP53 protein express 

         1 MGI phenotypic allele for Ctrc (no phenotypes)

    CTRC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ctrctm1Lex for CTRC

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTRC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTRC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTRC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTRC

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CTRC using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CTRC:
    hsa-miR-137
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CTRC
    Predesigned siRNA for gene silencing in human, mouse, rat CTRC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CTRC

    Clone
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    OriGene clones in human, mouse for CTRC (see all 5)
    OriGene ORF clones in mouse, rat for CTRC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTRC (NM_007272)
    Sino Biological Human cDNA Clone for CTRC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CTRC
    Browse ESI BIO Cell Lines and PureStem Progenitors for CTRC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTRC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    endoplasmic reticulum1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTRC
    Interactions:

        Search GeneGlobe Interaction Network for CTRC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for CTRC (Q998953 ENSP000003651164) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHKG1Q168163, ENSP000002973734I2D: score=2 STRING: ENSP00000297373
    SPINK1P009953, ENSP000002966954I2D: score=2 STRING: ENSP00000296695
    SERPINA3P010113I2D: score=2 
    PLAURENSP000003393284STRING: ENSP00000339328
    NEDD8ENSP000002504954STRING: ENSP00000250495
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS8635596

    CTRC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTRC

    3 Novoseek inferred chemical compound relationships for CTRC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trypsinogen 77.8 14 16505482 (3), 17592142 (2), 18172691 (1)
    serine 22 6 9538241 (3)
    calcium 12.1 4 9538241 (1)



    CTRC for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CTRC gene: 
    NM_007272.2  

    Unigene Cluster for CTRC:

    Chymotrypsin C (caldecrin)
    Hs.631869  [show with all ESTs]
    Unigene Representative Sequence: CR749296
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375949(uc001awi.1 uc001awj.1) ENST00000476813 ENST00000483406
    ENST00000375943
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CTRC using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CTRC:
    hsa-miR-137
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CTRC
    Predesigned siRNA for gene silencing in human, mouse, rat CTRC
    Clone
    Products:
         
    OriGene clones in human, mouse for CTRC (see all 5)
    OriGene ORF clones in mouse, rat for CTRC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTRC (NM_007272)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRC
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CTRC
    OriGene qSTAR qPCR primer pairs in human, mouse for CTRC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTRC
      QuantiTect SYBR Green Assays in human, mouse, rat CTRC
      QuantiFast Probe-based Assays in human, mouse, rat CTRC

    Additional mRNA sequence: 

    AK289447.1 BC015118.1 BC059779.1 CR749296.1 S82198.1 Y13697.1 

    3 DOTS entries:

    DT.444466  DT.100671111  DT.101977100 

    Selected AceView cDNA sequences (see all 87):

    CA943703 BM314365 BU783106 BU951407 BU789009 BI837452 AA366184 BM263405 
    CA866836 BQ632234 BM263708 BQ632041 BI832476 AA363469 AA366374 CK905007 
    BQ776695 BU789269 BC015118 BC059779 BU077589 CA776821 BI767919 BM091072 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CTRC    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8
    SP1:                                            -                                 
    SP2:                                            -           -     -               
    SP3:                                -           -                                 
    SP4:                                                                              


    ECgene alternative splicing isoforms for CTRC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTRC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAGCTGAG
    CTRC Expression
    About this image


    CTRC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Ovary (Reproductive System)
    CTRC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTRC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631869

    UniProtKB/Swiss-Prot: CTRC_HUMAN, Q99895
    Tissue specificity: Pancreas

        Custom PCR Arrays for CTRC
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    QuantiTect SYBR Green Assays in human, mouse, rat CTRC
    QuantiFast Probe-based Assays in human, mouse, rat CTRC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTRC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CTRC gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctrc1 , 5 chymotrypsin C (caldecrin)1, 5 79.1(n)1
    78.73(a)1
      4 (74.75 cM)5
    767011  NM_001033875.21  NP_001029047.11 
     1418149625 
    chicken
    (Gallus gallus)
    Aves CTRC1 chymotrypsin C (caldecrin) 71.21(n)
    67.8(a)
      430670  NM_001277917.1  NP_001264846.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.237792 Xenopus laevis transcribed sequence with weak similarity more 75.86(n)    CF284556.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054136.12   -- 77.24(n)   334304  BC054136.1 


    ENSEMBL Gene Tree for CTRC (if available)
    TreeFam Gene Tree for CTRC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTRC gene
    CTRL2  CELA2A2  CELA3B2  CTRB12  CELA12  CELA3A2  CELA2B2  CTRB22  
    Selected SIMAP similar genes for CTRC using alignment to 1 protein entry:     CTRC_HUMAN(see all similar genes):
    CELA2A    ELA2A    CELA1    CELA2B    CELA3B    ELA2B
    ELA3A    CELA3A    CTRB1    CTRB2    CTRL    OVCH1
    factor IX F9    CORIN    DKFZp779M0222    F9 p22    HGFAC    PRSS45

    CTRC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTRC (see all 337)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006781111,2,,4
    Pancreatitis, hereditary (PCTT)4 --15668214(+) CCTGCA/GGCCCG 2 Q R mis10--------
    rs2020581231,2,,4
    CPancreatitis, hereditary (PCTT)4 --15669175(+) ACTCCG/AGTGGC 2 /S /G mis11Minor allele frequency- A:0.00EU 1311
    rs1409932901,2,,4
    CPancreatitis, hereditary (PCTT)4 --15669229(+) GCATCG/ATCAGC 2 /I /V mis11Minor allele frequency- A:0.00NA 4552
    rs1425603291,2,,4
    C,FPancreatitis, hereditary (PCTT)4 --15669272(+) GAAGCC/TGGTAG 2 P L mis11Minor allele frequency- T:0.00NA 4552
    rs1219092931,2,,4
    C,FPancreatitis, hereditary (PCTT)4 other115669286(+) ACACCC/TGGGTG 2 R W mis12Minor allele frequency- T:0.00NA EU 5875
    VAR_0705224
    Pancreatitis, hereditary (PCTT)4--see VAR_0705222 G V mis40--------
    VAR_0435204
    Pancreatitis, hereditary (PCTT)4--see VAR_0435202 A T mis40--------
    VAR_0705384
    Pancreatitis, hereditary (PCTT)4--see VAR_0705382 V E mis40--------
    VAR_0705264
    Pancreatitis, hereditary (PCTT)4--see VAR_0705262 C Y mis40--------
    VAR_0435224
    Pancreatitis, hereditary (PCTT)4--see VAR_0435222 G R mis40--------

    HapMap Linkage Disequilibrium report for CTRC (15764935 - 15775737 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CTRC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2117572CNV Deletion18987734
    nsv833536CNV Loss17160897

    Human Gene Mutation Database (HGMD): CTRC
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTRC
    DNA2.0 Custom Variant and Variant Library Synthesis for CTRC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601405   
    OMIM disorders: 167800  
    UniProtKB/Swiss-Prot: CTRC_HUMAN, Q99895
  • Pancreatitis, hereditary (PCTT) [MIM:167800]: A disease characterized by pancreas inflammation, permanent
    destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry. Loss-of-function CTRC
    variants predispose to pancreatitis by diminishing its protective trypsin-degrading activity (PubMed:18059268).
    They cause loss of function by one or more of three mechanisms: reduced secretion, catalytic defect and increased
    degradation by trypsin (PubMed:22942235)

  • 15 diseases for CTRC:    
    About MalaCards
    pancreatitis, chronic    ctrc-related hereditary pancreatitis    meckel's diverticulum    fibrocalculous pancreatic diabetes
    prss1-related hereditary pancreatitis    tropical calcific pancreatitis    hereditary pancreatitis    appendicitis
    primary hyperparathyroidism    pancreatitis    hyperparathyroidism    malaria
    multiple myeloma    pancreatic cancer    myeloma

    2 diseases from the University of Copenhagen DISEASES database for CTRC:
    Pancreatitis     Appendicitis

    CTRC for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CTRC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatitis 67.3 4 18059268 (2), 18172691 (1)

    Genetic Association Database (GAD): CTRC
    Human Genome Epidemiology (HuGE) Navigator: CTRC (6 documents)

    Export disorders for CTRC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTRC gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with CTRC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis. (PubMed id 18172691)1, 2, 4, 9 Masson E....FAcrec C. (Hum. Genet. 2008)
    2. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. (PubMed id 18059268)1, 2, 4, 9 Rosendahl J.... Sahin-Toth M. (Nat. Genet. 2008)
    3. Molecular cloning and expression of human caldecrin. (PubMed id 8635596)1, 2, 3, 9 Tomomura A.... Saheki T. (FEBS Lett. 1996)
    4. Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan. (PubMed id 19407484)1, 2, 4, 9 Chang M.C....Wong J.M. (Pancreatology 2009)
    5. Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene. (PubMed id 9538241)1, 2, 9 Yoshino-Yasuda I....Saheki T. (J. Biochem. 1998)
    6. Identification of novel missense CTRC variants in Japanese patients with chronic pancreatitis. (PubMed id 23135764)1, 2 Masamune A....Shimosegawa T. (Gut 2013)
    7. Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants. (PubMed id 22580415)1, 2 Paliwal S....Chandak G.R. (Gut 2013)
    8. Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk. (PubMed id 22942235)1, 2 Beer S....Sahin-Toth M. (Gut 2013)
    9. Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation. (PubMed id 23430245)1, 2 Batra J....Radisky E.S. (J. Biol. Chem. 2013)
    10. Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. (PubMed id 19404200)1, 4 Derikx M.H....Drenth J.P. (amp 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11330 HGNC: 2523 AceView: CTRC Ensembl:ENSG00000162438 euGenes: HUgn11330
    ECgene: CTRC H-InvDB: CTRC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTRC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTRC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTRC gene:
    Search GeneIP for patents involving CTRC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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