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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTRC Gene

protein-coding   GIFtS: 61
GCID: GC01P015764

Chymotrypsin C (Caldecrin)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chymotrypsin C (Caldecrin)1 2     Elastase IV2
CLCR2 3 5     Serum Calcium Decreasing Factor2
Elastase 41 2     Caldecrin3
ELA42     EC 3.4.21.23
caldecrin2     EC 3.4.218
chymotrypsin-C2     

External Ids:    HGNC: 25231   Entrez Gene: 113302   Ensembl: ENSG000001624387   OMIM: 6014055   UniProtKB: Q998953   

Export aliases for CTRC gene to outside databases

Previous GC identifers: GC01P015162 GC01P014943 GC01P015033 GC01P015127 GC01P015510 GC01P015637 GC01P014284


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTRC Gene:
This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor
that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but
their full-length nature has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CTRC Gene: 
CTRC (chymotrypsin C (caldecrin)) is a protein-coding gene. Diseases associated with CTRC include ctrc-related hereditary pancreatitis, and tropical calcific pancreatitis. GO annotations related to this gene include peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is CTRL.

UniProtKB/Swiss-Prot: CTRC_HUMAN, Q99895
Function: Has chymotrypsin-type protease activity and hypocalcemic activity

Gene Wiki entry for CTRC (Chymotrypsin-C) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTRC gene promoter:
         HOXA3   Nkx5-1   LCR-F1   Tal-1beta   YY1   HFH-1   Msx-1   LyF-1   ITF-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTRC promoter sequence
   Search SABiosciences Chromatin IP Primers for CTRC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTRC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.21

CTRC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTRC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P015764:  view genomic region     (about GC identifiers)

Start:
15,764,935 bp from pter      End:
15,775,737 bp from pter
Size:
10,803 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CTRC_HUMAN, Q99895 (See protein sequence)
Recommended Name: Chymotrypsin-C precursor  
Size: 268 amino acids; 29484 Da
1 PDB 3D structure from and Proteopedia for CTRC:
4H4F (3D)    
Secondary accessions: A8K082 O00765 Q9NUH5

Explore the universe of human proteins at neXtProt for CTRC: NX_Q99895

Explore proteomics data for CTRC at MOPED 

4/5 DME Specific Peptides for CTRC (Q99895) (see all 5)
 GDSGGPL  DIALIKL  TRVSAYI  VLTAAHC 

CTRC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CTRC Protein Expression
REFSEQ proteins: NP_009203.2  
ENSEMBL proteins: 
 ENSP00000365116   ENSP00000365110  

Human Recombinant Protein Products for CTRC: 
Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for CTRC (Chymotrypsin C/CTRC)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for CTRC
OriGene Custom MassSpec 
OriGene Custom Protein Services for CTRC
GenScript Custom Purified and Recombinant Proteins Services for CTRC
Novus Biologicals CTRC Proteins
Novus Biologicals CTRC Lysates
Sino Biological Recombinant Protein for CTRC
Sino Biological Cell Lysate for CTRC 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 


CTRC Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for CTRC (Chymotrypsin C/CTRC)
Browse OriGene Antibodies
OriGene Custom Antibody Services for CTRC
GenScript Custom Superior Antibodies Services for CTRC
Novus Biologicals CTRC Antibodies
Abcam antibodies for CTRC
Browse Antibodies at Cloud-Clone Corp. 
ThermoFisher Antibodies for CTRC
LSBio Antibodies in human, mouse, rat for CTRC 

Assay Products for CTRC: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CTRC
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CTRC
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR001314 Peptidase_S1A
 IPR001254 Peptidase_S1
 IPR018114 Peptidase_S1_AS
 IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry Q99895

ProtoNet protein and cluster: Q99895

2 Blocks protein domains:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: CTRC_HUMAN, Q99895
Similarity: Belongs to the peptidase S1 family. Elastase subfamily
Similarity: Contains 1 peptidase S1 domain


CTRC for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CTRC_HUMAN, Q99895
Function: Has chymotrypsin-type protease activity and hypocalcemic activity
Catalytic activity: Preferential cleavage: Leu- -Xaa, Tyr- -Xaa, Phe- -Xaa, Met- -Xaa, Trp- -Xaa, Gln- -Xaa, Asn-
-Xaa

     Enzyme Numbers (IUBMB): EC 3.4.21.21 EC 3.4.212

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004252serine-type endopeptidase activity IEA--
GO:0008233peptidase activity TAS8635596
     
CTRC for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for CTRC:
 Decreased TP53 protein express 

     1 MGI phenotypic allele for Ctrc (no phenotypes)

CTRC for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Ctrctm1Lex for CTRC

   inGenious Targeting Laboratory - Custom generated mouse model solutions for CTRC 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTRC

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTRC 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTRC 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTRC
1 QIAGEN miScript miRNA Assays for microRNA that regulate CTRC:
hsa-miR-137
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CTRC
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTRC

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CTRC
Sirion Biotech Customized adenovirus for overexpression of CTRC

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for CTRC (see all 6)
OriGene ORF clones in mouse, rat for CTRC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CTRC (NM_007272)
Sino Biological Human cDNA Clone for CTRC
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRC
Sirion Biotech Customized lentivirus for stable overexpression of CTRC 
                     Customized lentivirus expression plasmids for stable overexpression of CTRC 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CTRC
Search LifeMap BioReagents cell lines for CTRC
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTRC


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTRC

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/6 Interacting proteins for CTRC (Q998953 ENSP000003651164) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
PHKG1Q168163, ENSP000002973734I2D: score=2 STRING: ENSP00000297373
SPINK1P009953, ENSP000002966954I2D: score=2 STRING: ENSP00000296695
SERPINA3P010113I2D: score=2 
PLAURENSP000003393284STRING: ENSP00000339328
NEDD8ENSP000002504954STRING: ENSP00000250495
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--

CTRC for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CTRC for compounds           About GeneDecksing

EMD Millipore small molecules for CTRC:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CTRC

3 Novoseek inferred chemical compound relationships for CTRC gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
trypsinogen 77.8 14 16505482 (3), 17592142 (2), 18172691 (1)
serine 22 6 9538241 (3)
calcium 12.1 4 9538241 (1)

Search CenterWatch for drugs/clinical trials and news about CTRC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CTRC gene: 
NM_007272.2  

Unigene Cluster for CTRC:

Chymotrypsin C (caldecrin)
Hs.631869  [show with all ESTs]
Unigene Representative Sequence: CR749296
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000375949(uc001awi.1 uc001awj.1) ENST00000476813 ENST00000483406
ENST00000375943
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTRC
1 QIAGEN miScript miRNA Assays for microRNA that regulate CTRC:
hsa-miR-137
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CTRC
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTRC
Clone
Products:
     
OriGene clones in human, mouse for CTRC (see all 6)
OriGene ORF clones in mouse, rat for CTRC
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CTRC (NM_007272)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRC
Sirion Biotech Customized lentivirus for stable overexpression of CTRC 
                     Customized lentivirus expression plasmids for stable overexpression of CTRC 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CTRC
OriGene qSTAR qPCR primer pairs in human, mouse for CTRC
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTRC
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTRC
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTRC

Additional mRNA sequence: 

AK289447.1 BC015118.1 BC059779.1 CR749296.1 S82198.1 Y13697.1 

3 DOTS entries:

DT.444466  DT.100671111  DT.101977100 

24/87 AceView cDNA sequences (see all 87):

AA366184 BM314365 BQ632234 BQ776695 BI832476 BU783106 BU789269 BI837452 
CA866836 BC059779 BU951407 AA363469 BM263405 BC015118 CK905007 CA943703 
BM263708 BU077589 BQ632041 BU789009 AA366374 BU788199 AW582871 BQ776832 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for CTRC    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8
SP1:                                            -                                 
SP2:                                            -           -     -               
SP3:                                -           -                                 
SP4:                                                                              


ECgene alternative splicing isoforms for CTRC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CTRC expression in normal human tissues (normalized intensities)      CTRC embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGAGCTGAG
CTRC Expression
About this image


CTRC expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Pancreas (Endocrine System)    fully expand to see all 2 entries
         Duct Cells Pancreatic Ducts
         Pancreatic Islet   
 
 Spinal Cord (Nervous System)
         Superior Cervical Ganglion   
 
 Neural Tube (Nervous System)
         Rhombencephalon

See CTRC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTRC

SOURCE GeneReport for Unigene cluster: Hs.631869

UniProtKB/Swiss-Prot: CTRC_HUMAN, Q99895
Tissue specificity: Pancreas

    SABiosciences Custom PCR Arrays for CTRC
Primer
Products:
OriGene qPCR primer pairs and template standards for CTRC
OriGene qSTAR qPCR primer pairs in human, mouse for CTRC
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTRC
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTRC
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTRC
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTRC

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CTRC gene from 5/14 species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ctrc1 , 5 chymotrypsin C (caldecrin)1, 5 79.1(n)1
78.73(a)1
  4 (74.75 cM)5
767011  NM_001033875.21  NP_001029047.11 
 1418149625 
chicken
(Gallus gallus)
Aves CTRC1 chymotrypsin C (caldecrin) 70.96(n)
67.8(a)
  430670  XM_428223.3  XP_428223.2 
African clawed frog
(Xenopus laevis)
Amphibia Xl.237792 Xenopus laevis transcribed sequence with weak similarity more 75.86(n)    CF284556.1 
zebrafish
(Danio rerio)
Actinopterygii BC054136.12   -- 77.24(n)   334304  BC054136.1 
fruit fly
(Drosophila melanogaster)
Insecta CG104723
CG115291
serine-type endopeptidase3
CG115291
37(a)
(best of 2)3
50.73(n)1
36.84(a)1
  65A53
393951  NM_140301.21  NP_648558.11 


ENSEMBL Gene Tree for CTRC (if available)
TreeFam Gene Tree for CTRC (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CTRC gene
CTRL2  CELA2A2  CELA3B2  CELA12  CTRB12  CELA3A2  CELA2B2  OVCH22  
CTRB22  OVCH12  
18/81 SIMAP similar genes for CTRC using alignment to 1 protein entry:     CTRC_HUMAN(see all similar genes):
CELA2A    ELA2A    CELA1    CELA2B    CELA3B    ELA2B
ELA3A    CELA3A    CTRB1    CTRB2    CTRL    OVCH1
factor IX F9    CORIN    DKFZp779M0222    F9    F9 p22    HGFAC

CTRC for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/316 SNPs in CTRC are shown (see all 316)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2014866131,2
Cuntested115669200(+) GTTGGA/CGAACG 2 E A mis11Minor allele frequency- C:0.00EU 1319
rs1219092941,2
Cother115664093(+) CACGTG/AGAGGC 2 /* /W stg11Minor allele frequency- A:0.00NA 4552
rs1219092931,2,4
C,Fother115669286(+) ACACCC/TGGGTG 2 R W mis12Minor allele frequency- T:0.00NA EU 5875
VAR_0435184
----see VAR_0435182 R Q mis40--------
VAR_0435234
----see VAR_0435232 G S mis40--------
VAR_0435194
----see VAR_0435192 Q R mis40--------
VAR_0109284
----see VAR_0109282 R W mis40--------
VAR_0435254
----see VAR_0435252 L R mis40--------
VAR_0435274
----see VAR_0435272 V I mis40--------
VAR_0435174
----see VAR_0435172 D N mis40--------

HapMap Linkage Disequilibrium report for CTRC (15764935 - 15775737 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for CTRC:    About this table     
Variant IDTypeSubtypePubMed ID
esv2117572CNV Deletion18987734
nsv833536CNV Loss17160897


Human Gene Mutation Database (HGMD): CTRC
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CTRC
DNA2.0 Custom Variant and Variant Library Synthesis for CTRC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 601405   
OMIM disorders: 167800  
UniProtKB/Swiss-Prot: CTRC_HUMAN, Q99895
  • Note=Genetic variations in CTRC can predispose to chronic pancreatitis by diminishing its protective
    trypsin-degrading activity

  • 7 diseases for CTRC:    About MalaCards
    ctrc-related hereditary pancreatitis    tropical calcific pancreatitis    meckel's diverticulum    hereditary pancreatitis
    appendicitis    pancreatitis    alcoholism

    2 diseases from the University of Copenhagen DISEASES database for CTRC:
    Pancreatitis     Appendicitis

    CTRC for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CTRC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatitis 67.3 4 18059268 (2), 18172691 (1)

    Genetic Association Database (GAD): CTRC
    Human Genome Epidemiology (HuGE) Navigator: CTRC (6 documents)

    Export disorders for CTRC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTRC gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with CTRC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis. (PubMed id 18059268)1, 2, 4, 9 Rosendahl J.... Sahin-Toth M. (2008)
    2. Molecular cloning and expression of human caldecrin. (PubMed id 8635596)1, 2, 3, 9 Tomomura A.... Saheki T. (1996)
    3. Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene. (PubMed id 9538241)1, 2, 9 Yoshino-Yasuda I....Saheki T. (1998)
    4. Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis. (PubMed id 18172691)1, 4, 9 Masson E....Ferec C. (2008)
    5. Association of novel chymotrypsin C gene variations and haplotypes in patients with chronic pancreatitis in Chinese in Taiwan. (PubMed id 19407484)1, 4, 9 Chang M.C....Wong J.M. (2009)
    6. Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. (PubMed id 19404200)1, 4 Derikx M.H....Drenth J.P. (2009)
    7. Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients. (PubMed id 19096130)1, 4 Kitahara K....Ota M. (2008)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y. (PubMed id 17592142)1, 9 Szmola R. and Sahin-Toth M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11330 HGNC: 2523 AceView: CTRC Ensembl:ENSG00000162438 euGenes: HUgn11330
    ECgene: CTRC H-InvDB: CTRC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTRC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTRC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CTRC gene:
    Search GeneIP for patents involving CTRC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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