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Aliases for CTRB2 Gene

Aliases for CTRB2 Gene

  • Chymotrypsinogen B2 2 3 5
  • EC 3.4.21.1 4 61
  • EC 3.4.21 61

External Ids for CTRB2 Gene

Previous GeneCards Identifiers for CTRB2 Gene

  • GC00U990074
  • GC16M073796
  • GC16M075237
  • GC16M060989

Summaries for CTRB2 Gene

GeneCards Summary for CTRB2 Gene

CTRB2 (Chymotrypsinogen B2) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CTRB1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTRB2 Gene

Genomics for CTRB2 Gene

Regulatory Elements for CTRB2 Gene

Enhancers for CTRB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G075233 1.3 ENCODE dbSUPER 22.7 -27.1 -27099 1.7 HDGF PKNOX1 ATF1 MLX CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 BCAR1 CTRB2 ENSG00000261783 LOC100506281 ENSG00000280152
GH16G075237 1.4 Ensembl ENCODE dbSUPER 12.5 -31.6 -31619 4.9 ELF3 MLX FUS ARID4B THRB RARA GLIS2 ZNF366 ZNF207 PCBP1 CTRB2 BCAR1 ZFP1 ENSG00000261783 CFDP1 ENSG00000280152 LOC100506281
GH16G075215 1.3 Ensembl ENCODE 13.2 -11.0 -10966 5.1 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A ENSG00000214331 RFWD3 CTRB2 BCAR1 ADAT1 LOC440386 ENSG00000261783 CFDP1 CTRB1
GH16G075420 1.4 FANTOM5 Ensembl ENCODE 11.1 -214.0 -214031 1.3 ELF3 PKNOX1 ARID4B FEZF1 ZBTB40 ZNF766 ZHX1 THAP11 SP5 SMAD5 ENSG00000261783 CTRB2 CHST6 RNU6-758P CFDP1 GC16M075409 ENSG00000252122
GH16G075260 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.1 -57.5 -57549 7.9 HDGF PKNOX1 MLX ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 YY1 BCAR1 ENSG00000259972 CTRB2 ENSG00000261783 TMEM170A TERF2IP LOC105371344
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CTRB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CTRB2 Gene

Chromosome:
16
Start:
75,204,096 bp from pter
End:
75,207,185 bp from pter
Size:
3,090 bases
Orientation:
Minus strand

Genomic View for CTRB2 Gene

Genes around CTRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTRB2 Gene

Proteins for CTRB2 Gene

  • Protein details for CTRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GPI1-CTRB2_HUMAN
    Recommended name:
    Chymotrypsinogen B2
    Protein Accession:
    Q6GPI1
    Secondary Accessions:
    • A8K707

    Protein attributes for CTRB2 Gene

    Size:
    263 amino acids
    Molecular mass:
    27923 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTRB2 Gene

Selected DME Specific Peptides for CTRB2 Gene

Q6GPI1:
  • LKIAKVFKN
  • DDFPAGTLC
  • GDSGGPL
  • DVVVAGEFDQGSDEEN
  • WVVTAAHC
  • SGGPLVC
  • FCGGSLI
  • GIVSWGS
  • HFCGGSL
  • WPWQVSL

Post-translational modifications for CTRB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTRB2 Gene

Domains & Families for CTRB2 Gene

Suggested Antigen Peptide Sequences for CTRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6GPI1

UniProtKB/Swiss-Prot:

CTRB2_HUMAN :
  • Belongs to the peptidase S1 family.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CTRB2: view

No data available for Gene Families for CTRB2 Gene

Function for CTRB2 Gene

Molecular function for CTRB2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Tyr- -Xaa, Trp- -Xaa, Phe- -Xaa, Leu- -Xaa.

Enzyme Numbers (IUBMB) for CTRB2 Gene

Gene Ontology (GO) - Molecular Function for CTRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity TAS --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity TAS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CTRB2: view

Animal Model Products

CRISPR Products

miRNA for CTRB2 Gene

miRTarBase miRNAs that target CTRB2

Inhibitory RNA Products

Clone Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTRB2 Gene

Localization for CTRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTRB2 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTRB2 gene
Compartment Confidence
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for CTRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CTRB2: view

Pathways & Interactions for CTRB2 Gene

genes like me logo Genes that share pathways with CTRB2: view

Gene Ontology (GO) - Biological Process for CTRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007586 digestion IEA --
GO:0009235 cobalamin metabolic process TAS --
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with CTRB2: view

No data available for SIGNOR curated interactions for CTRB2 Gene

Drugs & Compounds for CTRB2 Gene

No Compound Related Data Available

Transcripts for CTRB2 Gene

Unigene Clusters for CTRB2 Gene

Chymotrypsinogen B2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTRB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1:
SP2:
SP3: - -

Relevant External Links for CTRB2 Gene

GeneLoc Exon Structure for
CTRB2
ECgene alternative splicing isoforms for
CTRB2

Expression for CTRB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTRB2 Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for CTRB2 Gene

This gene is overexpressed in Pancreatic juice (59.1) and Pancreas (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CTRB2 Gene



Protein tissue co-expression partners for CTRB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTRB2 Gene:

CTRB2

SOURCE GeneReport for Unigene cluster for CTRB2 Gene:

Hs.632211

Evidence on tissue expression from TISSUES for CTRB2 Gene

  • Pancreas(5)
genes like me logo Genes that share expression patterns with CTRB2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTRB2 Gene

Orthologs for CTRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTRB2 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC479649 34
  • 87.33 (n)
CTRB1 35
  • 87 (a)
ManyToMany
-- 35
  • 85 (a)
ManyToMany
-- 35
  • 72 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ctrb1 34 16 35
  • 83.9 (n)
rat
(Rattus norvegicus)
Mammalia Ctrb1 34
  • 83.78 (n)
cow
(Bos Taurus)
Mammalia LOC100848132 34
  • 83.4 (n)
-- 35
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC431235 34
  • 71.74 (n)
-- 35
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ctrl 34
  • 64.89 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:136461 34 35
  • 70.09 (n)
zgc:112160 35
  • 64 (a)
ManyToMany
ctrb1 35
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Jon99Cii 35
  • 32 (a)
ManyToMany
Jon99Ciii 35
  • 32 (a)
ManyToMany
Jon44E 35
  • 31 (a)
ManyToMany
Jon66Cii 35
  • 31 (a)
ManyToMany
Jon99Fi 35
  • 31 (a)
ManyToMany
Jon99Fii 35
  • 31 (a)
ManyToMany
CG10469 35
  • 30 (a)
ManyToMany
CG8952 35
  • 30 (a)
ManyToMany
Jon25Bi 35
  • 30 (a)
ManyToMany
Jon25Biii 35
  • 30 (a)
ManyToMany
Jon66Ci 35
  • 30 (a)
ManyToMany
yip7 35
  • 30 (a)
ManyToMany
CG7542 35
  • 29 (a)
ManyToMany
Jon65Aii 35
  • 29 (a)
ManyToMany
Jon99Ci 35
  • 29 (a)
ManyToMany
CG10472 35
  • 28 (a)
ManyToMany
CG10477 35
  • 28 (a)
ManyToMany
CG18179 35
  • 28 (a)
ManyToMany
Jon65Aiii 35
  • 28 (a)
ManyToMany
CG11529 35
  • 27 (a)
ManyToMany
CG18180 35
  • 27 (a)
ManyToMany
CG8329 35
  • 27 (a)
ManyToMany
Jon25Bii 35
  • 27 (a)
ManyToMany
Jon65Ai 35
  • 27 (a)
ManyToMany
Jon65Aiv 35
  • 27 (a)
ManyToMany
CG3088 35
  • 26 (a)
ManyToMany
CG6462 35
  • 25 (a)
ManyToMany
sphinx2 35
  • 22 (a)
ManyToMany
sphinx1 35
  • 21 (a)
ManyToMany
Jon74E 35
  • 18 (a)
ManyToMany
CG6592 35
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
ManyToMany
Species where no ortholog for CTRB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTRB2 Gene

ENSEMBL:
Gene Tree for CTRB2 (if available)
TreeFam:
Gene Tree for CTRB2 (if available)

Paralogs for CTRB2 Gene

Paralogs for CTRB2 Gene

Pseudogenes.org Pseudogenes for CTRB2 Gene

genes like me logo Genes that share paralogs with CTRB2: view

Variants for CTRB2 Gene

Sequence variations from dbSNP and Humsavar for CTRB2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000012029 -- 75,206,239(+) CAGGT(C/G)CTAAT intron-variant
rs1000043253 -- 75,205,999(+) TGTGA(A/G)CAAGA intron-variant
rs1000649772 -- 75,203,954(+) AGATA(C/T)GAAGA downstream-variant-500B
rs1000715297 -- 75,209,061(+) CAGCC(C/G)CTAGC upstream-variant-2KB
rs1001457207 -- 75,206,662(+) AGGAG(C/T)TTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTRB2 Gene

Variant ID Type Subtype PubMed ID
dgv1638e59 OTHER inversion 20981092
dgv20n50 OTHER inversion 21212237
dgv25n47 OTHER inversion 21111241
dgv51n16 OTHER inversion 17901297
esv1000574 OTHER inversion 20482838
esv1356452 OTHER inversion 17803354
esv2504659 OTHER inversion 19546169
esv3582318 CNV loss 25503493
esv3582319 CNV loss 25503493
esv3582320 CNV loss 25503493
nsv482197 CNV gain 20164927
nsv516504 CNV gain+loss 19592680
nsv523405 CNV loss 19592680
nsv7286 OTHER inversion 18451855
nsv833282 CNV gain+loss 17160897

Variation tolerance for CTRB2 Gene

Gene Damage Index Score: 0.78; 16.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTRB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTRB2 Gene

Disorders for CTRB2 Gene

Relevant External Links for CTRB2

Genetic Association Database (GAD)
CTRB2
Human Genome Epidemiology (HuGE) Navigator
CTRB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTRB2

No disorders were found for CTRB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTRB2 Gene

Publications for CTRB2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Genomic cloning and partial characterization of human chymotrypsinogen gene. (PMID: 8186414) Hou D.X. … Soeda E. (Jpn. J. Hum. Genet. 1993) 2 3 64
  3. Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA. (PMID: 2917002) Tomita N. … Matsubara K. (Biochem. Biophys. Res. Commun. 1989) 2 3 64
  4. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3 64
  5. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PMID: 19430480) Barrett J.C. … Rich S.S. (Nat. Genet. 2009) 46 64

Products for CTRB2 Gene

Sources for CTRB2 Gene

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