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CTRB2 Gene

protein-coding   GIFtS: 48
GCID: GC16M075237

Chymotrypsinogen B2

  Search for CTRB2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chymotrypsinogen B21 2
EC 3.4.21.13 8
Chymotrypsin B22
EC 3.4.218

External Ids:    HGNC: 25221   Entrez Gene: 4403872   Ensembl: ENSG000001689287   UniProtKB: Q6GPI13   

Export aliases for CTRB2 gene to outside databases

Previous GC identifers: GC00U990074 GC16M073796 GC16M060989


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CTRB2 Gene:
CTRB2 (chymotrypsinogen B2) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CTRL.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTRB2 gene promoter:
         NF-1   GATA-3   Tal-1beta   SREBP-1b   GATA-2   GATA-1   PPAR-gamma1   SREBP-1a   PPAR-gamma2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTRB2 promoter sequence
   Search Chromatin IP Primers for CTRB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTRB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q22.3

CTRB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTRB2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M075237:  view genomic region     (about GC identifiers)

Start:
75,237,994 bp from pter      End:
75,241,083 bp from pter
Size:
3,090 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTRB2_HUMAN, Q6GPI1 (See protein sequence)
Recommended Name: Chymotrypsinogen B2 precursor  
Size: 263 amino acids; 27923 Da
Secondary accessions: A8K707

Explore the universe of human proteins at neXtProt for CTRB2: NX_Q6GPI1

Explore proteomics data for CTRB2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CTRB2 (Q6GPI1) (see all 10)
     SGGPLVC  GDSGGPL  FCGGSLI  WPWQVSL 


    See CTRB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001020371.3  
    ENSEMBL proteins: 
     ENSP00000303963   ENSP00000454599   ENSP00000457279   ENSP00000455207  
    Reactome Protein details: Q6GPI1

    CTRB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for CTRB2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CTRB2
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTRB2

     
    Search eBioscience for Proteins for CTRB2 

    CTRB2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    OriGene Custom Antibody Services for CTRB2
    Search for Antibodies for CTRB2 at Abcam
    Cloud-Clone Corp. Antibodies for CTRB2
    Search ThermoFisher Antibodies for CTRB2
    Search LSBio for Antibodies for CTRB2

    CTRB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CTRB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CTRB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CTRB2
    Cloud-Clone Corp. CLIAs for CTRB2
    Search eBioscience for ELISAs for CTRB2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q6GPI1

    ProtoNet protein and cluster: Q6GPI1

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: CTRB2_HUMAN, Q6GPI1
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with CTRB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTRB2_HUMAN, Q6GPI1
    Catalytic activity: Preferential cleavage: Tyr- -Xaa, Trp- -Xaa, Phe- -Xaa, Leu- -Xaa

         Enzyme Numbers (IUBMB): EC 3.4.21.11 2 EC 3.4.212

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    Find genes that share ontologies with CTRB2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTRB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTRB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTRB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTRB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CTRB2:
    hsa-mir-335-5p (MIRT017370)

    Block miRNA regulation of human, mouse, rat CTRB2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CTRB2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CTRB2
    Predesigned siRNA for gene silencing in human, mouse, rat CTRB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CTRB2

    Clone
    Products:
         
    OriGene clones in human, mouse for CTRB2 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTRB2 (NM_001025200)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CTRB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CTRB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTRB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTRB2_HUMAN, Q6GPI1: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with CTRB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTRB2 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Defective BTD causes biotidinase deficiency
    Defective BTD causes biotidinase deficiency1.00
    Metabolism of vitamins and cofactors1.00
    Defective AMN causes hereditary megaloblastic anemia 11.00
    Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
    Defective MMAA causes methylmalonic aciduria type cblA1.00
    Defective MUT causes methylmalonic aciduria mut type1.00
    Defective CD320 causes methylmalonic aciduria1.00
    Defects in cobalamin (B12) metabolism1.00
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    3Metabolism
    Metabolism0.38
    4Matrix Metalloproteinases
    Activation of Matrix Metalloproteinases0.37
    5Disease
    Disease


    Find genes that share SuperPaths with CTRB2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for CTRB2
        Cobalamin (Cbl, vitamin B12) transport and metabolism
    Activation of Matrix Metalloproteinases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTRB2
    Interactions:

        Search GeneGlobe Interaction Network for CTRB2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CTRB2 (ENSP000003039634) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRSS1ENSP000003087204STRING: ENSP00000308720
    PRSS3ENSP000003542804STRING: ENSP00000354280
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0007586digestion IEA--
    GO:0009235cobalamin metabolic process TAS--

    Find genes that share ontologies with CTRB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTRB2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTRB2 gene: 
    NM_001025200.3  

    Unigene Cluster for CTRB2:

    Chymotrypsinogen B2
    Hs.632211  [show with all ESTs]
    Unigene Representative Sequence: BF676199
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303037(uc002fdr.3) ENST00000562106 ENST00000567767 ENST00000562387
    ENST00000481611 ENST00000565656
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CTRB2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CTRB2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CTRB2
    Predesigned siRNA for gene silencing in human, mouse, rat CTRB2
    Clone
    Products:
         
    OriGene clones in human, mouse for CTRB2 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTRB2 (NM_001025200)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRB2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CTRB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTRB2
      QuantiTect SYBR Green Assays in human, mouse, rat CTRB2
      QuantiFast Probe-based Assays in human, mouse, rat CTRB2

    Additional mRNA sequence: 

    AK131056.1 AK225933.1 AK291822.1 BC073145.1 

    13 DOTS entries:

    DT.92421819  DT.99939380  DT.120699689  DT.120699706  DT.450700  DT.100820255  DT.100820256  DT.100820257 
    DT.120699696  DT.40221398  DT.100820247  DT.100820254  DT.120699704 

    Selected AceView cDNA sequences (see all 375):

    BU078707 CA941687 AA366241 CA843255 BQ269686 CA844004 BM310422 BU074935 
    AA367430 BQ778443 CA941501 W52845 BU784594 AA363464 BU785691 BM272082 
    CA941722 BI712390 CA947129 CB068314 CA947063 BQ778278 BQ776388 AA363526 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CTRB2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
    SP1:                                                            
    SP2:                                                            
    SP3:                                            -     -         


    ECgene alternative splicing isoforms for CTRB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTRB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTCCTCT
    CTRB2 Expression
    About this image

    CTRB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTRB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632211
        Custom PCR Arrays for CTRB2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CTRB2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTRB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CTRB2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctrb11 chymotrypsinogen B1 83.9(n)
    85.17(a)
      66473  NM_025583.2  NP_079859.2 
    chicken
    (Gallus gallus)
    Aves LOC4312351 chymotrypsinogen 2-like 71.74(n)
    69.2(a)
      431235  NM_001277636.1  NP_001264565.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    67(a)
    1 → many
    GL343840.1(1393-8494)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ctrl1 chymotrypsin-like 64.89(n)
    64.64(a)
      548358  NM_001015686.1  NP_001015686.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1364611 zgc:136461 70.09(n)
    66.54(a)
      692313  NM_001045282.2  NP_001038747.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Jon99Ciii6
    Jon99Cii6
    (see all 31)
    Jonah 99Cii
    (see all 31)
    32(a)
    32(a)
    (see all 31)
    many ↔ many
    many ↔ many
    (see all 31)
    3R(25747938-25748774)
    3R(25749476-25750337)


    ENSEMBL Gene Tree for CTRB2 (if available)
    TreeFam Gene Tree for CTRB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTRB2 gene
    CTRL2  CTRC2  CELA2A2  CELA3B2  CTRB12  CELA12  CELA3A2  CELA2B2  
    Selected SIMAP similar genes for CTRB2 using alignment to 4 protein entries:     CTRB2_HUMAN (see all proteins) (see all similar genes):
    CTRB1    CTRL    FLJ00366    PRSS1    TMPRSS5    TMPRSS3
    CELA1    CELA3B    TMPRSS15    TMPRSS9    serase-1B    CELA2A
    ELA2A    CELA2B    DF    ELA2B    KLKB1    OVCH1

    Find genes that share paralogs with CTRB2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CTRB2
    PGOHUM00000262504


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTRB2 (see all 190)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs569746081,2
    C,F--75237592(+) AGGTGT/CGAGGG 1 -- int16Minor allele frequency- C:0.21NA CSA WA EA 363
    rs1501993461,2
    --75237655(+) TGGACA/TTGGGG 1 -- int10--------
    rs1114184021,2
    C--75237658(+) ACATGA/GGGGAC 1 -- int10--------
    rs1128994901,2
    F--75237800(+) CAGCAG/AGTAGG 1 -- int11Minor allele frequency- A:0.50CSA 4
    rs1387376961,2
    C--75237811(+) GCCTAA/CATTCT 1 -- int10--------
    rs116473801,2
    C,H--75237824(+) ACCCAA/G/TGGTGG 1 -- int10--------
    rs800536421,2
    F--75237838(+) CGTGAG/CCAGGC 1 -- int11Minor allele frequency- C:0.08WA 118
    rs116473881,2
    H--75237863(+) CCTCAG/TCTTCC 1 -- int10--------
    rs1161241881,2
    F--75237914(+) GGGAAC/TGGTAG 1 -- int11Minor allele frequency- T:0.04WA 118
    rs2005812851,2
    C--75238055(+) GCTGCA/GGGCTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CTRB2 (75237994 - 75241083 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CTRB2 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523405CNV Loss19592680
    dgv2912n71CNV Loss21882294
    nsv482197CNV Gain20164927
    nsv833282CNV Gain+Loss17160897
    nsv516504CNV Gain+Loss19592680
    esv2504659OTHER Inversion19546169
    dgv20n50OTHER Inversion21212237
    dgv51n16OTHER Inversion17901297
    esv1356452OTHER Inversion17803354
    dgv25n47OTHER Inversion21111241

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTRB2
    DNA2.0 Custom Variant and Variant Library Synthesis for CTRB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with CTRB2           About GenesLikeMe

    Genetic Association Database (GAD): CTRB2
    Human Genome Epidemiology (HuGE) Navigator: CTRB2 (1 document)

    Export disorders for CTRB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTRB2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CTRB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic cloning and partial characterization of human chymotrypsinogen gene. (PubMed id 8186414)1, 3 Hou D.X....Soeda E. (Jpn. J. Hum. Genet. 1993)
    2. Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA. (PubMed id 2917002)1, 3 Tomita N.... Matsubara K. (Biochem. Biophys. Res. Commun. 1989)
    3. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)4 Barrett J.C....Rich S.S. (Nat. Genet. 2009)
    4. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 440387 HGNC: 2522 AceView: LOC440387 Ensembl:ENSG00000168928 euGenes: HUgn440387
    ECgene: CTRB2 H-InvDB: CTRB2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CTRB2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Chymotrypsin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTRB2 gene:
    Search GeneIP for patents involving CTRB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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