CTRB2 Gene
protein-coding GIFtS: 46
GCID: GC16M075237
|
|
chymotrypsinogen B2
| |
Aliases
for CTRB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chymotrypsinogen B21 2 | | EC 3.4.21.13 8 | | Chymotrypsin B22 | | EC 3.4.218 |
Export aliases for CTRB2 gene to outside databasesPrevious GC identifers: GC00U990074 GC16M073796 GC16M060989 |
Summaries
for CTRB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CTRB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CTRB2 gene promoter:
NF-1 GATA-3 Tal-1beta SREBP-1b GATA-2 GATA-1 PPAR-gamma1 SREBP-1a PPAR-gamma2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CTRB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTRB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q23.1 Ensembl cytogenetic band: 16q23.1 HGNC cytogenetic band: 16q22.3CTRB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M075237: view genomic region
(about GC identifiers)
Start:
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75,237,994 bp from pter |
End:
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75,241,083 bp from pter |
Size:
|
3,090 bases |
Orientation:
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minus strand |
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Proteins
for CTRB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CTRB2_HUMAN, Q6GPI1 (See
protein sequence)Recommended Name: Chymotrypsinogen B2 precursor Size: 263 amino acids; 27923 Da
Subcellular location: Secreted, extracellular space
Secondary accessions: A8K707Explore the universe of human proteins at neXtProt for CTRB2: NX_Q6GPI1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6GPI1
4/10 DME Specific Peptides for CTRB2 (Q6GPI1) (see all 10)
CTRB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001020371.3
ENSEMBL proteins: ENSP00000303963 ENSP00000454599 ENSP00000457279 ENSP00000455207 Reactome Protein details: Q6GPI1
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- | | GO:0005615 | extracellular space |
IEA | -- |
CTRB2 for ontologies About GeneDecksing
CTRB2 Antibody Products:
Assay Products for CTRB2: |
Protein
Domains /
Families
for CTRB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CTRB2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6GPI1ProtoNet protein and cluster: Q6GPI1 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: CTRB2_HUMAN, Q6GPI1Similarity: Belongs to the peptidase S1 familySimilarity: Contains 1 peptidase S1 domain |
Function
for CTRB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CTRB2_HUMAN, Q6GPI1Catalytic activity: Preferential cleavage: Tyr- -Xaa, Trp- -Xaa, Phe- -Xaa, Leu- -XaaEnzyme Numbers (IUBMB): EC 3.4.21.11 2 EC 3.4.212
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTRB2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTRB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CTRB2 (NM_001025200) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTRB2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRB2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
IEA | -- |
CTRB2 for ontologies About GeneDecksing
|
Pathways & Interactions
for CTRB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Degradation of the extracellular matrix | | | 2 | Activation of proMMP10 | | | 3 | Collagen formation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for CTRB2
CTRB2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTRB2
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CTRB2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CTRB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CTRB2
Search CenterWatch for drugs/clinical trials and news about CTRB2
|
Transcripts
for CTRB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CTRB2 gene: NM_001025200.3 Unigene Cluster for CTRB2: Chymotrypsinogen B2 Hs.632211 [show with all ESTs]Unigene Representative Sequence: BF6761996 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000303037(uc002fdr.3) ENST00000562106 ENST00000567767 ENST00000562387
ENST00000481611 ENST00000565656
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTRB2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTRB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CTRB2 (NM_001025200) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTRB2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRB2 |
Additional cDNA sequence: AK131056.1 AK225933.1 AK291822.1 BC073145.1 13 DOTS entries: DT.92421819 DT.99939380 DT.120699689 DT.120699706 DT.450700 DT.100820255 DT.100820256 DT.100820257 DT.120699696 DT.40221398 DT.100820247 DT.100820254 DT.120699704 24/375 AceView cDNA sequences (see all 375): CB068314 CA866166 BI712623 BQ271426 BQ776388 CA946791 AA844977 W52845 CA843255 BM272082 CA941722 BU784594 BQ778443 BM263993 CA867847 AA367430 BU072031 AA367398 AA366388 AA363526 AA363464 BM263839 CA844004 BU785691
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CTRB2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | |
ECgene alternative splicing isoforms for CTRB2
|
Expression
for CTRB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CTRB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTTCCTCT
About this image
See CTRB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTRB2
SOURCE GeneReport for Unigene cluster: Hs.632211
SABiosciences Custom PCR Arrays for CTRB2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTRB2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTRB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTRB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTRB2 |
Orthologs
for CTRB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CTRB2 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for CTRB2 (if available)
TreeFam Gene Tree for CTRB2 (if available) |
Paralogs
for CTRB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CTRB2 gene
- CTRL2 CTRC2 CELA2A2 CELA3B2 CELA12 CTRB12 CELA3A2 CELA2B2
18/117 SIMAP similar genes for CTRB2 using alignment to 4 protein entries: CTRB2_HUMAN (see all proteins)
(see all similar genes):CTRB1 CTRL FLJ00366 PRSS1 TMPRSS5 TMPRSS3
CELA1 CELA3B TMPRSS15 TMPRSS9 serase-1B CELA2A
ELA2A CELA2B DF ELA2B KLKB1 OVCH1
CTRB2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CTRB2
PGOHUM00000262504
|
Genomic Variants
for CTRB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CTRB2 (75237994 - 75241083 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for CTRB2
3 CNVs: 49758 49757 4967
6 Inversions: 103338 37184 37186 37185 29455 37183 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTRB2 |
|
Disorders
/ Diseases
for CTRB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CTRB2 for disorders About GeneDecksing
2  diseases for CTRB2: About MalaCardsacute pancreatitis pancreatitis
Human Genome Epidemiology (HuGE) Navigator: CTRB2 (1 document)
Export disorders for CTRB2 gene to outside databases
|
Publications
for CTRB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CTRB2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CTRB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genomic cloning and partial characterization of human chymotrypsinogen gene. (PubMed id 8186414)1, 3 Hou D.X....Soeda E. (1993)
- Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA. (PubMed id 2917002)1, 3 Tomita N.... Matsubara K. (1989)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for CTRB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CTRB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CTRB2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CTRB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CTRB2 | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/Chymotrypsin |
|
| | |
About This Section
| Patent Information for CTRB2 gene:
Search GeneIP for patents involving CTRB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CTRB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CTRB2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTRB2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTRB2 | | | OriGene Protein Over-expression Lysate for CTRB2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CTRB2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTRB2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTRB2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CTRB2 | | OriGene Custom Protein Services for CTRB2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTRB2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTRB2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTRB2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTRB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTRB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTRB2 |
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 |  |  |  | |
| | | | Search Tocris compounds for CTRB2 |
| |  |  |  |  | | | | |
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 | | | CTRB2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for CTRB2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRB2 |
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