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Aliases for CTRB2 Gene

Aliases for CTRB2 Gene

  • Chymotrypsinogen B2 2 3 5
  • EC 3.4.21.1 4 63
  • EC 3.4.21 63

External Ids for CTRB2 Gene

Previous GeneCards Identifiers for CTRB2 Gene

  • GC00U990074
  • GC16M073796
  • GC16M075237
  • GC16M060989

Summaries for CTRB2 Gene

GeneCards Summary for CTRB2 Gene

CTRB2 (Chymotrypsinogen B2) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Metabolism. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTRB2 Gene

Genomics for CTRB2 Gene

Regulatory Elements for CTRB2 Gene

Genomic Location for CTRB2 Gene

Chromosome:
16
Start:
75,204,096 bp from pter
End:
75,207,185 bp from pter
Size:
3,090 bases
Orientation:
Minus strand

Genomic View for CTRB2 Gene

Genes around CTRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTRB2 Gene

Proteins for CTRB2 Gene

  • Protein details for CTRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GPI1-CTRB2_HUMAN
    Recommended name:
    Chymotrypsinogen B2
    Protein Accession:
    Q6GPI1
    Secondary Accessions:
    • A8K707

    Protein attributes for CTRB2 Gene

    Size:
    263 amino acids
    Molecular mass:
    27923 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTRB2 Gene

Proteomics data for CTRB2 Gene at MOPED

Post-translational modifications for CTRB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTRB2 Gene

Domains & Families for CTRB2 Gene

Suggested Antigen Peptide Sequences for CTRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6GPI1

UniProtKB/Swiss-Prot:

CTRB2_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CTRB2: view

No data available for Gene Families for CTRB2 Gene

Function for CTRB2 Gene

Molecular function for CTRB2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Tyr- -Xaa, Trp- -Xaa, Phe- -Xaa, Leu- -Xaa.

Enzyme Numbers (IUBMB) for CTRB2 Gene

Animal Model Products

CRISPR Products

miRNA for CTRB2 Gene

miRTarBase miRNAs that target CTRB2

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTRB2 Gene

Localization for CTRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTRB2 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTRB2 Gene COMPARTMENTS Subcellular localization image for CTRB2 gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CTRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with CTRB2: view

Pathways & Interactions for CTRB2 Gene

genes like me logo Genes that share pathways with CTRB2: view

Interacting Proteins for CTRB2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000303963%0d%0a9606.ENSP00000308720%0d%0a9606.ENSP00000354280%0d%0a9606.ENSP00000225728%0d%0a
Selected Interacting proteins: ENSP00000303963 for CTRB2 Gene via STRING

Gene Ontology (GO) - Biological Process for CTRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0007586 digestion IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with CTRB2: view

No data available for SIGNOR curated interactions for CTRB2 Gene

Drugs & Compounds for CTRB2 Gene

No Compound Related Data Available

Transcripts for CTRB2 Gene

Unigene Clusters for CTRB2 Gene

Chymotrypsinogen B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTRB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1:
SP2:
SP3: - -

Relevant External Links for CTRB2 Gene

GeneLoc Exon Structure for
CTRB2
ECgene alternative splicing isoforms for
CTRB2

Expression for CTRB2 Gene

mRNA expression in normal human tissues for CTRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTRB2 Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for CTRB2 Gene

This gene is overexpressed in Pancreatic juice (59.1) and Pancreas (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTRB2 Gene



SOURCE GeneReport for Unigene cluster for CTRB2 Gene Hs.632211

genes like me logo Genes that share expression patterns with CTRB2: view

Protein tissue co-expression partners for CTRB2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CTRB2 Gene

Orthologs for CTRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTRB2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC100848132 35
  • 83.4 (n)
  • 80.61 (a)
-- 36
  • 68 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 72 (a)
ManyToMany
-- 36
  • 85 (a)
ManyToMany
CTRB1 36
  • 87 (a)
ManyToMany
LOC479649 35
  • 87.33 (n)
  • 87.07 (a)
mouse
(Mus musculus)
Mammalia Ctrb1 16
Ctrb1 36
  • 85 (a)
OneToMany
Ctrb1 35
  • 83.9 (n)
  • 85.17 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ctrb1 35
  • 83.78 (n)
  • 84.79 (a)
chicken
(Gallus gallus)
Aves LOC431235 35
  • 71.74 (n)
  • 69.2 (a)
-- 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ctrl 35
  • 64.89 (n)
  • 64.64 (a)
zebrafish
(Danio rerio)
Actinopterygii ctrb1 36
  • 38 (a)
ManyToMany
zgc:112160 36
  • 64 (a)
ManyToMany
zgc:136461 36
  • 67 (a)
ManyToMany
zgc:136461 35
  • 70.09 (n)
  • 66.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10469 36
  • 30 (a)
ManyToMany
CG10472 36
  • 28 (a)
ManyToMany
CG10477 36
  • 28 (a)
ManyToMany
CG11529 36
  • 27 (a)
ManyToMany
CG18179 36
  • 28 (a)
ManyToMany
CG18180 36
  • 27 (a)
ManyToMany
CG3088 36
  • 26 (a)
ManyToMany
CG6462 36
  • 25 (a)
ManyToMany
CG6592 36
  • 17 (a)
ManyToMany
CG7542 36
  • 29 (a)
ManyToMany
CG8329 36
  • 27 (a)
ManyToMany
CG8952 36
  • 30 (a)
ManyToMany
Jon25Bi 36
  • 30 (a)
ManyToMany
Jon25Bii 36
  • 27 (a)
ManyToMany
Jon25Biii 36
  • 30 (a)
ManyToMany
Jon44E 36
  • 31 (a)
ManyToMany
Jon65Ai 36
  • 27 (a)
ManyToMany
Jon65Aii 36
  • 29 (a)
ManyToMany
Jon65Aiii 36
  • 28 (a)
ManyToMany
Jon65Aiv 36
  • 27 (a)
ManyToMany
Jon66Ci 36
  • 30 (a)
ManyToMany
Jon66Cii 36
  • 31 (a)
ManyToMany
Jon74E 36
  • 18 (a)
ManyToMany
Jon99Ci 36
  • 29 (a)
ManyToMany
Jon99Cii 36
  • 32 (a)
ManyToMany
Jon99Ciii 36
  • 32 (a)
ManyToMany
Jon99Fi 36
  • 31 (a)
ManyToMany
Jon99Fii 36
  • 31 (a)
ManyToMany
sphinx1 36
  • 21 (a)
ManyToMany
sphinx2 36
  • 22 (a)
ManyToMany
yip7 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
ManyToMany
Species with no ortholog for CTRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTRB2 Gene

ENSEMBL:
Gene Tree for CTRB2 (if available)
TreeFam:
Gene Tree for CTRB2 (if available)

Paralogs for CTRB2 Gene

Paralogs for CTRB2 Gene

Pseudogenes.org Pseudogenes for CTRB2 Gene

genes like me logo Genes that share paralogs with CTRB2: view

Variants for CTRB2 Gene

Sequence variations from dbSNP and Humsavar for CTRB2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4737 - 75,204,205(-) GTGTC(A/G)CCAAG reference, missense
rs1130509 -- 75,204,320(-) ATGGG(C/T)GACTC reference, synonymous-codon
rs1049293 -- 75,204,287(-) AAGGA(C/T)GGAGC reference, synonymous-codon
rs1049298 -- 75,204,236(-) TGCTC(C/T)ACCAC reference, synonymous-codon
rs7498299 -- 75,207,789(+) aaaaa(A/G)aaaAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CTRB2 Gene

Variant ID Type Subtype PubMed ID
nsv833282 CNV Gain+Loss 17160897
nsv7286 OTHER Inversion 18451855
nsv516504 CNV Gain+Loss 19592680
nsv523405 CNV Loss 19592680
dgv2912n71 CNV Loss 21882294
dgv51n16 OTHER Inversion 17901297
nsv482197 CNV Gain 20164927
esv2504659 OTHER Inversion 19546169
dgv20n50 OTHER Inversion 21212237
esv1000574 OTHER Inversion 20482838
esv1356452 OTHER Inversion 17803354
dgv25n47 OTHER Inversion 21111241

Variation tolerance for CTRB2 Gene

Gene Damage Index Score: 0.78; 16.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTRB2 Gene

HapMap Linkage Disequilibrium report
CTRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTRB2 Gene

Disorders for CTRB2 Gene

Relevant External Links for CTRB2

Genetic Association Database (GAD)
CTRB2
Human Genome Epidemiology (HuGE) Navigator
CTRB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTRB2

No disorders were found for CTRB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTRB2 Gene

Publications for CTRB2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Genomic cloning and partial characterization of human chymotrypsinogen gene. (PMID: 8186414) Hou D.X. … Soeda E. (Jpn. J. Hum. Genet. 1993) 2 3
  3. Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA. (PMID: 2917002) Tomita N. … Matsubara K. (Biochem. Biophys. Res. Commun. 1989) 2 3
  4. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for CTRB2 Gene

Sources for CTRB2 Gene

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