Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CTRB2 Gene

Aliases for CTRB2 Gene

  • Chymotrypsinogen B2 2 3
  • EC 3.4.21.1 4 63
  • EC 3.4.21 63

External Ids for CTRB2 Gene

Previous GeneCards Identifiers for CTRB2 Gene

  • GC00U990074
  • GC16M073796
  • GC16M075237
  • GC16M060989

Summaries for CTRB2 Gene

GeneCards Summary for CTRB2 Gene

CTRB2 (Chymotrypsinogen B2) is a Protein Coding gene. Among its related pathways are Disease and Degradation of the extracellular matrix. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTRB2 Gene

Genomics for CTRB2 Gene

Regulatory Elements for CTRB2 Gene

Genomic Location for CTRB2 Gene

Start:
75,204,096 bp from pter
End:
75,207,185 bp from pter
Size:
3,090 bases
Orientation:
Minus strand

Genomic View for CTRB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTRB2 Gene

Proteins for CTRB2 Gene

  • Protein details for CTRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GPI1-CTRB2_HUMAN
    Recommended name:
    Chymotrypsinogen B2
    Protein Accession:
    Q6GPI1
    Secondary Accessions:
    • A8K707

    Protein attributes for CTRB2 Gene

    Size:
    263 amino acids
    Molecular mass:
    27923 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTRB2 Gene

Proteomics data for CTRB2 Gene at MOPED

Post-translational modifications for CTRB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTRB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CTRB2 Gene

Suggested Antigen Peptide Sequences for CTRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6GPI1

UniProtKB/Swiss-Prot:

CTRB2_HUMAN :
  • Q6GPI1
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CTRB2: view

No data available for Gene Families for CTRB2 Gene

Function for CTRB2 Gene

Molecular function for CTRB2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Tyr- -Xaa, Trp- -Xaa, Phe- -Xaa, Leu- -Xaa.

Enzyme Numbers (IUBMB) for CTRB2 Gene

Gene Ontology (GO) - Molecular Function for CTRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with CTRB2: view

Animal Model Products

CRISPR Products

miRNA for CTRB2 Gene

miRTarBase miRNAs that target CTRB2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTRB2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CTRB2 Gene

Localization for CTRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTRB2 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTRB2 Gene COMPARTMENTS Subcellular localization image for CTRB2 gene
Compartment Confidence
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for CTRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CTRB2: view

Pathways for CTRB2 Gene

SuperPathways for CTRB2 Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Degradation of the extracellular matrix
3 Disease
4 Metabolism
5 Matrix Metalloproteinases
genes like me logo Genes that share pathways with CTRB2: view

Interacting Proteins for CTRB2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000303963%0d%0a9606.ENSP00000354280%0d%0a9606.ENSP00000308720%0d%0a9606.ENSP00000225728%0d%0a
Selected Interacting proteins: ENSP00000303963 for CTRB2 Gene via STRING

Gene Ontology (GO) - Biological Process for CTRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0007586 digestion IEA --
GO:0009235 cobalamin metabolic process TAS --
genes like me logo Genes that share ontologies with CTRB2: view

Transcripts for CTRB2 Gene

Unigene Clusters for CTRB2 Gene

Chymotrypsinogen B2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTRB2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTRB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1:
SP2:
SP3: - -

Relevant External Links for CTRB2 Gene

GeneLoc Exon Structure for
CTRB2
ECgene alternative splicing isoforms for
CTRB2

Expression for CTRB2 Gene

mRNA expression in normal human tissues for CTRB2 Gene

mRNA differential expression in normal tissues according to GTEx for CTRB2 Gene

This gene is overexpressed in Pancreas (52.9).

Protein differential expression in normal tissues for CTRB2 Gene

This gene is overexpressed in Pancreatic juice (59.1) and Pancreas (9.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CTRB2 Gene

SOURCE GeneReport for Unigene cluster for CTRB2 Gene Hs.632211

genes like me logo Genes that share expressions with CTRB2: view

Expression partners for CTRB2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CTRB2 Gene

Orthologs for CTRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTRB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100848132 35
  • 83.4 (n)
  • 80.61 (a)
-- 36
  • 68 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC479649 35
  • 87.33 (n)
  • 87.07 (a)
-- 36
  • 72 (a)
ManyToMany
-- 36
  • 85 (a)
ManyToMany
CTRB1 36
  • 87 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ctrb1 35
  • 83.9 (n)
  • 85.17 (a)
Ctrb1 36
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ctrb1 35
  • 83.78 (n)
  • 84.79 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CTRB2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC431235 35
  • 71.74 (n)
  • 69.2 (a)
-- 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ctrl 35
  • 64.89 (n)
  • 64.64 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:136461 35
  • 70.09 (n)
  • 66.54 (a)
ctrb1 36
  • 38 (a)
ManyToMany
zgc:112160 36
  • 64 (a)
ManyToMany
zgc:136461 36
  • 67 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10469 36
  • 30 (a)
ManyToMany
CG10472 36
  • 28 (a)
ManyToMany
CG10477 36
  • 28 (a)
ManyToMany
CG11529 36
  • 27 (a)
ManyToMany
CG18179 36
  • 28 (a)
ManyToMany
CG18180 36
  • 27 (a)
ManyToMany
CG3088 36
  • 26 (a)
ManyToMany
CG6462 36
  • 25 (a)
ManyToMany
CG6592 36
  • 17 (a)
ManyToMany
CG7542 36
  • 29 (a)
ManyToMany
CG8329 36
  • 27 (a)
ManyToMany
CG8952 36
  • 30 (a)
ManyToMany
Jon25Bi 36
  • 30 (a)
ManyToMany
Jon25Bii 36
  • 27 (a)
ManyToMany
Jon25Biii 36
  • 30 (a)
ManyToMany
Jon44E 36
  • 31 (a)
ManyToMany
Jon65Ai 36
  • 27 (a)
ManyToMany
Jon65Aii 36
  • 29 (a)
ManyToMany
Jon65Aiii 36
  • 28 (a)
ManyToMany
Jon65Aiv 36
  • 27 (a)
ManyToMany
Jon66Ci 36
  • 30 (a)
ManyToMany
Jon66Cii 36
  • 31 (a)
ManyToMany
Jon74E 36
  • 18 (a)
ManyToMany
Jon99Ci 36
  • 29 (a)
ManyToMany
Jon99Cii 36
  • 32 (a)
ManyToMany
Jon99Ciii 36
  • 32 (a)
ManyToMany
Jon99Fi 36
  • 31 (a)
ManyToMany
Jon99Fii 36
  • 31 (a)
ManyToMany
sphinx1 36
  • 21 (a)
ManyToMany
sphinx2 36
  • 22 (a)
ManyToMany
yip7 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
ManyToMany
Species with no ortholog for CTRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTRB2 Gene

ENSEMBL:
Gene Tree for CTRB2 (if available)
TreeFam:
Gene Tree for CTRB2 (if available)

Paralogs for CTRB2 Gene

Paralogs for CTRB2 Gene

Pseudogenes.org Pseudogenes for CTRB2 Gene

genes like me logo Genes that share paralogs with CTRB2: view

Variants for CTRB2 Gene

Sequence variations from dbSNP and Humsavar for CTRB2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs4737 - 75,204,205(-) GTGTC(A/G)CCAAG missense, reference
rs889512 -- 75,208,114(-) CATCA(C/G)TTCTC upstream-variant-2KB
rs1049293 -- 75,204,287(-) AAGGA(C/T)GGAGC reference, synonymous-codon
rs1049298 -- 75,204,236(-) TGCTC(C/T)ACCAC synonymous-codon, reference
rs1049299 -- 75,204,232(-) CTACC(A/T)CCACG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CTRB2 Gene

Variant ID Type Subtype PubMed ID
nsv833282 CNV Gain+Loss 17160897
nsv7286 OTHER Inversion 18451855
nsv516504 CNV Gain+Loss 19592680
nsv523405 CNV Loss 19592680
dgv2912n71 CNV Loss 21882294
dgv51n16 OTHER Inversion 17901297
nsv482197 CNV Gain 20164927
esv2504659 OTHER Inversion 19546169
dgv20n50 OTHER Inversion 21212237
esv1000574 OTHER Inversion 20482838
esv1356452 OTHER Inversion 17803354
dgv25n47 OTHER Inversion 21111241

Relevant External Links for CTRB2 Gene

HapMap Linkage Disequilibrium report
CTRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTRB2 Gene

Disorders for CTRB2 Gene

Relevant External Links for CTRB2

Genetic Association Database (GAD)
CTRB2
Human Genome Epidemiology (HuGE) Navigator
CTRB2

No disorders were found for CTRB2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CTRB2 Gene

Publications for CTRB2 Gene

  1. Genomic cloning and partial characterization of human chymotrypsinogen gene. (PMID: 8186414) Hou D.X. … Soeda E. (Jpn. J. Hum. Genet. 1993) 2 3
  2. Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA. (PMID: 2917002) Tomita N. … Matsubara K. (Biochem. Biophys. Res. Commun. 1989) 2 3
  3. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for CTRB2 Gene

Sources for CTRB2 Gene

Back to Top

Content