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Aliases for CTRB1 Gene

Aliases for CTRB1 Gene

  • Chymotrypsinogen B1 2 3
  • EC 3.4.21.1 4 64
  • CTRB 3 4
  • Chymotrypsinogen B 3
  • EC 3.4.21 64

External Ids for CTRB1 Gene

Previous Symbols for CTRB1 Gene

  • CTRB

Summaries for CTRB1 Gene

Entrez Gene Summary for CTRB1 Gene

  • The protein encoded by this gene is one of a family of serine proteases that is secreted into the gastrointestinal tract as an inactive precursor, which is activated by proteolytic cleavage with trypsin. [provided by RefSeq, Oct 2011]

GeneCards Summary for CTRB1 Gene

CTRB1 (Chymotrypsinogen B1) is a Protein Coding gene. Among its related pathways are Disease and Degradation of the extracellular matrix. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA2B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTRB1 Gene

Genomics for CTRB1 Gene

Genomic Location for CTRB1 Gene

Start:
75,218,986 bp from pter
End:
75,224,924 bp from pter
Size:
5,939 bases
Orientation:
Plus strand

Genomic View for CTRB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTRB1 Gene

Regulatory Elements for CTRB1 Gene

Proteins for CTRB1 Gene

  • Protein details for CTRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17538-CTRB1_HUMAN
    Recommended name:
    Chymotrypsinogen B
    Protein Accession:
    P17538
    Secondary Accessions:

    Protein attributes for CTRB1 Gene

    Size:
    263 amino acids
    Molecular mass:
    27870 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTRB1 Gene

Proteomics data for CTRB1 Gene at MOPED

Post-translational modifications for CTRB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTRB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CTRB1 Gene

UniProtKB/Swiss-Prot:

CTRB1_HUMAN
Domain:
  • Contains 1 peptidase S1 domain.:
    • P17538
Family:
  • Belongs to the peptidase S1 family.:
    • P17538
genes like me logo Genes that share domains with CTRB1: view

No data available for Gene Families for CTRB1 Gene

Function for CTRB1 Gene

Molecular function for CTRB1 Gene

GENATLAS Biochemistry: chymotrypsinogen B1
UniProtKB/Swiss-Prot CatalyticActivity: Preferential cleavage: Tyr- -Xaa, Trp- -Xaa, Phe- -Xaa, Leu- -Xaa.

Enzyme Numbers (IUBMB) for CTRB1 Gene

Gene Ontology (GO) - Molecular Function for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity NAS 2917002
genes like me logo Genes that share ontologies with CTRB1: view

Phenotypes for CTRB1 Gene

GenomeRNAi human phenotypes for CTRB1:
genes like me logo Genes that share phenotypes with CTRB1: view

miRNA for CTRB1 Gene

miRTarBase miRNAs that target CTRB1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CTRB1 Gene

Localization for CTRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTRB1 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTRB1 Gene COMPARTMENTS Subcellular localization image for CTRB1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CTRB1: view

Pathways for CTRB1 Gene

SuperPathways for CTRB1 Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Degradation of the extracellular matrix
3 Disease
4 Metabolism
5 Pancreatic secretion
genes like me logo Genes that share pathways with CTRB1: view

Interacting Proteins for CTRB1 Gene

Gene Ontology (GO) - Biological Process for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0007586 digestion IEA --
GO:0009235 cobalamin metabolic process TAS --
genes like me logo Genes that share ontologies with CTRB1: view

Transcripts for CTRB1 Gene

mRNA/cDNA for CTRB1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(154) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTRB1 Gene

Chymotrypsinogen B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTRB1 Gene

No ASD Table

Relevant External Links for CTRB1 Gene

GeneLoc Exon Structure for
CTRB1
ECgene alternative splicing isoforms for
CTRB1

Expression for CTRB1 Gene

mRNA expression in normal human tissues for CTRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTRB1 Gene

This gene is overexpressed in Pancreas (52.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CTRB1 Gene

SOURCE GeneReport for Unigene cluster for CTRB1 Gene Hs.610926

genes like me logo Genes that share expressions with CTRB1: view

Orthologs for CTRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTRB1 36
  • 96.7 (n)
  • 97.34 (a)
CTRB1 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 69 (a)
OneToMany
CTRB1 36
  • 87.2 (n)
  • 86.31 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 74 (a)
ManyToMany
-- 37
  • 86 (a)
ManyToMany
CTRB2 36
  • 87.2 (n)
  • 86.69 (a)
mouse
(Mus musculus)
Mammalia Ctrb1 16
Ctrb1 37
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 55 (a)
ManyToMany
-- 37
  • 74 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 46 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC64417 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733231 36
  • 64.26 (n)
  • 64.26 (a)
LOC394984 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1189 36
zebrafish
(Danio rerio)
Actinopterygii ctrb1 37
  • 38 (a)
ManyToMany
wufb61f07 36
zgc:136461 37
  • 68 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta CLIPD2 36
  • 49.86 (n)
  • 41.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10469 37
  • 30 (a)
ManyToMany
CG10472 37
  • 28 (a)
ManyToMany
CG10477 37
  • 27 (a)
ManyToMany
CG11529 37
  • 27 (a)
ManyToMany
CG18179 37
  • 28 (a)
ManyToMany
CG18180 37
  • 27 (a)
ManyToMany
CG3088 37
  • 27 (a)
ManyToMany
CG31728 36
  • 51.72 (n)
  • 40.95 (a)
CG6462 37
  • 24 (a)
ManyToMany
CG6592 37
  • 17 (a)
ManyToMany
CG7542 37
  • 29 (a)
ManyToMany
CG8329 37
  • 27 (a)
ManyToMany
CG8952 37
  • 30 (a)
ManyToMany
Jon25Bi 37
  • 30 (a)
ManyToMany
Jon25Bii 37
  • 28 (a)
ManyToMany
Jon25Biii 37
  • 30 (a)
ManyToMany
Jon44E 37
  • 31 (a)
ManyToMany
Jon65Ai 37
  • 28 (a)
ManyToMany
Jon65Aii 37
  • 30 (a)
ManyToMany
Jon65Aiii 37
  • 28 (a)
ManyToMany
Jon65Aiv 37
  • 27 (a)
ManyToMany
Jon66Ci 37
  • 30 (a)
ManyToMany
Jon66Cii 37
  • 31 (a)
ManyToMany
Jon74E 37
  • 18 (a)
ManyToMany
Jon99Ci 37
  • 28 (a)
ManyToMany
Jon99Cii 37
  • 32 (a)
ManyToMany
Jon99Ciii 37
  • 32 (a)
ManyToMany
Jon99Fi 37
  • 31 (a)
ManyToMany
Jon99Fii 37
  • 31 (a)
ManyToMany
sphinx1 37
  • 20 (a)
ManyToMany
sphinx2 37
  • 21 (a)
ManyToMany
yip7 37
  • 30 (a)
ManyToMany
CG10472 38
  • 33 (a)
CG11836 38
  • 40 (a)
CG8172 38
  • 32 (a)
mas 38
  • 35 (a)
Sb 38
  • 37 (a)
CG8213 38
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 25 (a)
ManyToMany
Species with no ortholog for CTRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTRB1 Gene

ENSEMBL:
Gene Tree for CTRB1 (if available)
TreeFam:
Gene Tree for CTRB1 (if available)

Paralogs for CTRB1 Gene

Paralogs for CTRB1 Gene

genes like me logo Genes that share paralogs with CTRB1: view

Variants for CTRB1 Gene

Sequence variations from dbSNP and Humsavar for CTRB1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs889515 -- 75,217,401(+) CACTG(C/T)GTCTT upstream-variant-2KB
rs1130448 -- 75,219,043(+) TCCCT(C/T)GTGGG synonymous-codon, reference
rs1130449 -- 75,219,044(+) CCCTT(C/G)TGGGG missense, reference
rs1130450 -- 75,219,049(+) GTGGG(G/T)GCCGC reference, synonymous-codon
rs1130452 -- 75,219,050(+) TGGGG(A/G)CCGCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for CTRB1 Gene

Variant ID Type Subtype PubMed ID
nsv833282 CNV Gain+Loss 17160897
nsv7286 OTHER Inversion 18451855
nsv516504 CNV Gain+Loss 19592680
nsv523405 CNV Loss 19592680
dgv2912n71 CNV Loss 21882294
dgv51n16 OTHER Inversion 17901297
esv2504659 OTHER Inversion 19546169
dgv20n50 OTHER Inversion 21212237
esv1000574 OTHER Inversion 20482838
esv1356452 OTHER Inversion 17803354
dgv25n47 OTHER Inversion 21111241
nsv149 OTHER Inversion 15895083
nsv906911 CNV Loss 21882294
nsv482198 CNV Gain 20164927
esv2668023 CNV Deletion 23128226

Relevant External Links for CTRB1 Gene

HapMap Linkage Disequilibrium report
CTRB1

Disorders for CTRB1 Gene

(1) University of Copenhagen DISEASES for CTRB1 Gene

Relevant External Links for CTRB1

Genetic Association Database (GAD)
CTRB1
Human Genome Epidemiology (HuGE) Navigator
CTRB1
genes like me logo Genes that share disorders with CTRB1: view

No data available for UniProtKB/Swiss-Prot for CTRB1 Gene

Publications for CTRB1 Gene

  1. Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA. (PMID: 2917002) Tomita N. … Matsubara K. (Biochem. Biophys. Res. Commun. 1989) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 49
  4. Genomic cloning and partial characterization of human chymotrypsinogen gene. (PMID: 8186414) Hou D.X. … Soeda E. (Jpn. J. Hum. Genet. 1993) 2 3
  5. Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor. (PMID: 10713514) Mac Sweeney A. … Higgins T.M. (Acta Crystallogr. D Biol. Crystallogr. 2000) 3

Products for CTRB1 Gene

Sources for CTRB1 Gene

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