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Aliases for CTRB1 Gene

Aliases for CTRB1 Gene

  • Chymotrypsinogen B1 2 3 5
  • EC 3.4.21.1 4 61
  • CTRB 3 4
  • Chymotrypsinogen B 3
  • EC 3.4.21 61

External Ids for CTRB1 Gene

Previous HGNC Symbols for CTRB1 Gene

  • CTRB

Previous GeneCards Identifiers for CTRB1 Gene

  • GC16M066168
  • GC16P076213
  • GC16P074991
  • GC16P075032
  • GC16P075003
  • GC16P073810
  • GC16P075252
  • GC16P061006

Summaries for CTRB1 Gene

Entrez Gene Summary for CTRB1 Gene

  • This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This gene is located adjacent to a related chymotrypsinogen gene. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2016]

GeneCards Summary for CTRB1 Gene

CTRB1 (Chymotrypsinogen B1) is a Protein Coding gene. Diseases associated with CTRB1 include Common Bile Duct Disease. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CTRB2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTRB1 Gene

Genomics for CTRB1 Gene

Regulatory Elements for CTRB1 Gene

Enhancers for CTRB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F075198 1.1 Ensembl ENCODE 13.1 -20.6 -20619 0.6 KLF1 NRF1 ZNF133 BCAR1 CTRB1 LOC100506281 ENSG00000252122 CTRB2 ZFP1 RPS4Y1P1
GH16F075222 0.7 Ensembl ENCODE 0.8 +3.5 3531 0.2 CTCF SAP130 ARID4B MAX ZIC2 RAD21 THRB ZFHX2 CREM EGR2 BCAR1 CTRB1 LOC100506281
GH16F075215 0.9 Ensembl ENCODE 0.8 -0.8 -836 5.1 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 CTRB2 BCAR1 ENSG00000261783 CFDP1 CTRB1
GH16F075207 0.2 ENCODE 0.4 -10.3 -10258 1.5 CTRB2 ENSG00000261783 BCAR1 ADAT1 CTRB1
GH16F075206 0.2 ENCODE 0.4 -11.5 -11542 1.0 CTCF ZFHX2 GLI4 EGR2 CTRB2 BCAR1 ENSG00000261783 CTRB1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CTRB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CTRB1 Gene

Chromosome:
16
Start:
75,218,986 bp from pter
End:
75,224,924 bp from pter
Size:
5,939 bases
Orientation:
Plus strand

Genomic View for CTRB1 Gene

Genes around CTRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTRB1 Gene

Proteins for CTRB1 Gene

  • Protein details for CTRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17538-CTRB1_HUMAN
    Recommended name:
    Chymotrypsinogen B
    Protein Accession:
    P17538

    Protein attributes for CTRB1 Gene

    Size:
    263 amino acids
    Molecular mass:
    27713 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTRB1 Gene

Selected DME Specific Peptides for CTRB1 Gene

P17538:
  • LKIAKVFKN
  • DDFPAGTLC
  • GDSGGPL
  • DVVVAGEFDQGSDEEN
  • WVVTAAHC
  • SGGPLVC
  • FCGGSLI
  • GIVSWGS
  • HFCGGSL
  • WPWQVSL

Post-translational modifications for CTRB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTRB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CTRB1
  • Cloud-Clone Corp. Antibodies for CTRB1

Domains & Families for CTRB1 Gene

Suggested Antigen Peptide Sequences for CTRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17538

UniProtKB/Swiss-Prot:

CTRB1_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CTRB1: view

No data available for Gene Families for CTRB1 Gene

Function for CTRB1 Gene

Molecular function for CTRB1 Gene

GENATLAS Biochemistry:
chymotrypsinogen B1
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Tyr- -Xaa, Trp- -Xaa, Phe- -Xaa, Leu- -Xaa.

Enzyme Numbers (IUBMB) for CTRB1 Gene

Gene Ontology (GO) - Molecular Function for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity TAS --
GO:0008233 peptidase activity IEA --
GO:0008236 serine-type peptidase activity IEA,TAS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CTRB1: view

Phenotypes for CTRB1 Gene

GenomeRNAi human phenotypes for CTRB1:
genes like me logo Genes that share phenotypes with CTRB1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CTRB1

miRNA for CTRB1 Gene

miRTarBase miRNAs that target CTRB1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTRB1 Gene

Localization for CTRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTRB1 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTRB1 Gene COMPARTMENTS Subcellular localization image for CTRB1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CTRB1: view

Pathways & Interactions for CTRB1 Gene

genes like me logo Genes that share pathways with CTRB1: view

Gene Ontology (GO) - Biological Process for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007586 digestion IEA --
GO:0009235 cobalamin metabolic process TAS --
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with CTRB1: view

No data available for SIGNOR curated interactions for CTRB1 Gene

Drugs & Compounds for CTRB1 Gene

(16) Drugs for CTRB1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprotinin Approved, Withdrawn Pharma Target Inhibitor of bovine pancreatic trypsin 24
(2S) N-ACETYL-L-ALANYL-ALPHAL-PHENYLALANYL-CHLOROETHYLKETONE Experimental Pharma Target 0
1,1,1-TRIFLUORO-3-((N-ACETYL)-L-LEUCYLAMIDO)-4-PHENYL-BUTAN-2-ONE(N-ACETYL-L-LEUCYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) Experimental Pharma Target 0
1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) Experimental Pharma Target 0
2,4-Dihydroxy-Trans Cinnamic Acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with CTRB1: view

Transcripts for CTRB1 Gene

mRNA/cDNA for CTRB1 Gene

Unigene Clusters for CTRB1 Gene

Chymotrypsinogen B1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTRB1 Gene

No ASD Table

Relevant External Links for CTRB1 Gene

GeneLoc Exon Structure for
CTRB1
ECgene alternative splicing isoforms for
CTRB1

Expression for CTRB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTRB1 Gene

mRNA differential expression in normal tissues according to GTEx for CTRB1 Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for CTRB1 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTRB1 Gene



Protein tissue co-expression partners for CTRB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CTRB1 Gene:

CTRB1

SOURCE GeneReport for Unigene cluster for CTRB1 Gene:

Hs.610926
genes like me logo Genes that share expression patterns with CTRB1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CTRB1 Gene

Orthologs for CTRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTRB1 34 35
  • 96.7 (n)
cow
(Bos Taurus)
Mammalia CTRB1 34
  • 87.2 (n)
-- 35
  • 69 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CTRB2 34
  • 87.2 (n)
-- 35
  • 86 (a)
ManyToMany
-- 35
  • 74 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ctrb1 35
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733231 34
  • 64.26 (n)
LOC394984 34
African clawed frog
(Xenopus laevis)
Amphibia MGC64417 34
zebrafish
(Danio rerio)
Actinopterygii zgc:136461 35
  • 68 (a)
ManyToMany
ctrb1 35
  • 38 (a)
ManyToMany
wufb61f07 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1189 34
fruit fly
(Drosophila melanogaster)
Insecta CG31728 34
  • 51.72 (n)
CG11836 36
  • 40 (a)
Sb 36
  • 37 (a)
CG8213 36
  • 36 (a)
mas 36
  • 35 (a)
CG10472 36 35
  • 33 (a)
CG8172 36
  • 32 (a)
Jon99Cii 35
  • 32 (a)
ManyToMany
Jon99Ciii 35
  • 32 (a)
ManyToMany
Jon44E 35
  • 31 (a)
ManyToMany
Jon66Cii 35
  • 31 (a)
ManyToMany
Jon99Fi 35
  • 31 (a)
ManyToMany
Jon99Fii 35
  • 31 (a)
ManyToMany
CG10469 35
  • 30 (a)
ManyToMany
CG8952 35
  • 30 (a)
ManyToMany
Jon25Bi 35
  • 30 (a)
ManyToMany
Jon25Biii 35
  • 30 (a)
ManyToMany
Jon65Aii 35
  • 30 (a)
ManyToMany
Jon66Ci 35
  • 30 (a)
ManyToMany
yip7 35
  • 30 (a)
ManyToMany
CG7542 35
  • 29 (a)
ManyToMany
CG18179 35
  • 28 (a)
ManyToMany
Jon25Bii 35
  • 28 (a)
ManyToMany
Jon65Ai 35
  • 28 (a)
ManyToMany
Jon65Aiii 35
  • 28 (a)
ManyToMany
Jon99Ci 35
  • 28 (a)
ManyToMany
CG10477 35
  • 27 (a)
ManyToMany
CG11529 35
  • 27 (a)
ManyToMany
CG18180 35
  • 27 (a)
ManyToMany
CG3088 35
  • 27 (a)
ManyToMany
CG8329 35
  • 27 (a)
ManyToMany
Jon65Aiv 35
  • 27 (a)
ManyToMany
CG6462 35
  • 24 (a)
ManyToMany
sphinx2 35
  • 21 (a)
ManyToMany
sphinx1 35
  • 20 (a)
ManyToMany
Jon74E 35
  • 18 (a)
ManyToMany
CG6592 35
  • 17 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta CLIPD2 34
  • 49.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
ManyToMany
Species where no ortholog for CTRB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTRB1 Gene

ENSEMBL:
Gene Tree for CTRB1 (if available)
TreeFam:
Gene Tree for CTRB1 (if available)

Paralogs for CTRB1 Gene

Paralogs for CTRB1 Gene

genes like me logo Genes that share paralogs with CTRB1: view

Variants for CTRB1 Gene

Sequence variations from dbSNP and Humsavar for CTRB1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs193920783 Uncertain significance 75,224,707(+) CAGGG(C/T)GACTC upstream-variant-2KB, reference, synonymous-codon, stop-gained
rs10871306 -- 75,220,782(+) AGATG(C/G)AGTTT intron-variant
rs111318796 -- 75,218,122(+) TCTCA(A/G)AAAAA upstream-variant-2KB
rs111395330 -- 75,222,634(+) GGAGG(C/T)GGAGG intron-variant
rs11149808 -- 75,219,863(+) GCTTG(A/T)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTRB1 Gene

Variant ID Type Subtype PubMed ID
dgv1638e59 OTHER inversion 20981092
dgv20n50 OTHER inversion 21212237
dgv25n47 OTHER inversion 21111241
dgv51n16 OTHER inversion 17901297
esv1000574 OTHER inversion 20482838
esv1356452 OTHER inversion 17803354
esv2504659 OTHER inversion 19546169
esv2668023 CNV deletion 23128226
esv3582319 CNV loss 25503493
esv3582320 CNV loss 25503493
esv3639087 CNV loss 21293372
nsv1116159 CNV deletion 24896259
nsv1127514 CNV deletion 24896259
nsv149 OTHER inversion 15895083
nsv482198 CNV gain 20164927
nsv516504 CNV gain+loss 19592680
nsv523405 CNV loss 19592680
nsv7286 OTHER inversion 18451855
nsv833282 CNV gain+loss 17160897

Variation tolerance for CTRB1 Gene

Gene Damage Index Score: 2.48; 43.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTRB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTRB1 Gene

Disorders for CTRB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CTRB1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
common bile duct disease
  • common bile duct diseases
- elite association - COSMIC cancer census association via MalaCards
Search CTRB1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CTRB1

Genetic Association Database (GAD)
CTRB1
Human Genome Epidemiology (HuGE) Navigator
CTRB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTRB1
genes like me logo Genes that share disorders with CTRB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTRB1 Gene

Publications for CTRB1 Gene

  1. Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA. (PMID: 2917002) Tomita N. … Matsubara K. (Biochem. Biophys. Res. Commun. 1989) 2 3 4 64
  2. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genomic cloning and partial characterization of human chymotrypsinogen gene. (PMID: 8186414) Hou D.X. … Soeda E. (Jpn. J. Hum. Genet. 1993) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CTRB1 Gene

Sources for CTRB1 Gene

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