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Aliases for CTRB1 Gene

Aliases for CTRB1 Gene

  • Chymotrypsinogen B1 2 3 5
  • EC 3.4.21.1 4 63
  • CTRB 3 4
  • EC 3.4.21 63

External Ids for CTRB1 Gene

Previous HGNC Symbols for CTRB1 Gene

  • CTRB

Previous GeneCards Identifiers for CTRB1 Gene

  • GC16M066168
  • GC16P076213
  • GC16P074991
  • GC16P075032
  • GC16P075003
  • GC16P073810
  • GC16P075252
  • GC16P061006

Summaries for CTRB1 Gene

Entrez Gene Summary for CTRB1 Gene

  • The protein encoded by this gene is one of a family of serine proteases that is secreted into the gastrointestinal tract as an inactive precursor, which is activated by proteolytic cleavage with trypsin. [provided by RefSeq, Oct 2011]

GeneCards Summary for CTRB1 Gene

CTRB1 (Chymotrypsinogen B1) is a Protein Coding gene. Among its related pathways are Pancreatic secretion and Protein digestion and absorption. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA2B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTRB1 Gene

Genomics for CTRB1 Gene

Regulatory Elements for CTRB1 Gene

Enhancers for CTRB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CTRB1 on UCSC Golden Path with GeneCards custom track

Promoters for CTRB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CTRB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CTRB1 Gene

Chromosome:
16
Start:
75,218,986 bp from pter
End:
75,224,924 bp from pter
Size:
5,939 bases
Orientation:
Plus strand

Genomic View for CTRB1 Gene

Genes around CTRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTRB1 Gene

Proteins for CTRB1 Gene

  • Protein details for CTRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17538-CTRB1_HUMAN
    Recommended name:
    Chymotrypsinogen B
    Protein Accession:
    P17538

    Protein attributes for CTRB1 Gene

    Size:
    263 amino acids
    Molecular mass:
    27870 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTRB1 Gene

Proteomics data for CTRB1 Gene at MOPED

Post-translational modifications for CTRB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTRB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CTRB1 Gene

Suggested Antigen Peptide Sequences for CTRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17538

UniProtKB/Swiss-Prot:

CTRB1_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CTRB1: view

No data available for Gene Families for CTRB1 Gene

Function for CTRB1 Gene

Molecular function for CTRB1 Gene

GENATLAS Biochemistry:
chymotrypsinogen B1
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Tyr- -Xaa, Trp- -Xaa, Phe- -Xaa, Leu- -Xaa.

Enzyme Numbers (IUBMB) for CTRB1 Gene

Phenotypes for CTRB1 Gene

GenomeRNAi human phenotypes for CTRB1:
genes like me logo Genes that share phenotypes with CTRB1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CTRB1

miRNA for CTRB1 Gene

miRTarBase miRNAs that target CTRB1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTRB1 Gene

Localization for CTRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTRB1 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTRB1 Gene COMPARTMENTS Subcellular localization image for CTRB1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with CTRB1: view

Pathways & Interactions for CTRB1 Gene

genes like me logo Genes that share pathways with CTRB1: view

Interacting Proteins for CTRB1 Gene

Gene Ontology (GO) - Biological Process for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0007586 digestion IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with CTRB1: view

No data available for SIGNOR curated interactions for CTRB1 Gene

Drugs & Compounds for CTRB1 Gene

(16) Drugs for CTRB1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprotinin Approved, Withdrawn Pharma Target Inhibitor of bovine pancreatic trypsin 24
(2S) N-ACETYL-L-ALANYL-ALPHAL-PHENYLALANYL-CHLOROETHYLKETONE Experimental Pharma Target 0
1,1,1-TRIFLUORO-3-((N-ACETYL)-L-LEUCYLAMIDO)-4-PHENYL-BUTAN-2-ONE(N-ACETYL-L-LEUCYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) Experimental Pharma Target 0
1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) Experimental Pharma Target 0
2,4-Dihydroxy-Trans Cinnamic Acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with CTRB1: view

Transcripts for CTRB1 Gene

mRNA/cDNA for CTRB1 Gene

Unigene Clusters for CTRB1 Gene

Chymotrypsinogen B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTRB1 Gene

No ASD Table

Relevant External Links for CTRB1 Gene

GeneLoc Exon Structure for
CTRB1
ECgene alternative splicing isoforms for
CTRB1

Expression for CTRB1 Gene

mRNA expression in normal human tissues for CTRB1 Gene

mRNA differential expression in normal tissues according to GTEx for CTRB1 Gene

This gene is overexpressed in Pancreas (x52.9).

Protein differential expression in normal tissues from HIPED for CTRB1 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CTRB1 Gene



SOURCE GeneReport for Unigene cluster for CTRB1 Gene Hs.610926

genes like me logo Genes that share expression patterns with CTRB1: view

Protein tissue co-expression partners for CTRB1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CTRB1 Gene

Orthologs for CTRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTRB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTRB1 35
  • 87.2 (n)
  • 86.31 (a)
-- 36
  • 69 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CTRB2 35
  • 87.2 (n)
  • 86.69 (a)
-- 36
  • 74 (a)
ManyToMany
-- 36
  • 86 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia CTRB1 35
  • 96.7 (n)
  • 97.34 (a)
CTRB1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ctrb1 36
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733231 35
  • 64.26 (n)
  • 64.26 (a)
LOC394984 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64417 35
zebrafish
(Danio rerio)
Actinopterygii wufb61f07 35
ctrb1 36
  • 38 (a)
ManyToMany
zgc:136461 36
  • 68 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1189 35
fruit fly
(Drosophila melanogaster)
Insecta CG10472 37
  • 33 (a)
CG11836 37
  • 40 (a)
CG8172 37
  • 32 (a)
CG8213 37
  • 36 (a)
mas 37
  • 35 (a)
Sb 37
  • 37 (a)
CG31728 35
  • 51.72 (n)
  • 40.95 (a)
CG10469 36
  • 30 (a)
ManyToMany
CG10472 36
  • 28 (a)
ManyToMany
CG10477 36
  • 27 (a)
ManyToMany
CG11529 36
  • 27 (a)
ManyToMany
CG18179 36
  • 28 (a)
ManyToMany
CG18180 36
  • 27 (a)
ManyToMany
CG3088 36
  • 27 (a)
ManyToMany
CG6462 36
  • 24 (a)
ManyToMany
CG6592 36
  • 17 (a)
ManyToMany
CG7542 36
  • 29 (a)
ManyToMany
CG8329 36
  • 27 (a)
ManyToMany
CG8952 36
  • 30 (a)
ManyToMany
Jon25Bi 36
  • 30 (a)
ManyToMany
Jon25Bii 36
  • 28 (a)
ManyToMany
Jon25Biii 36
  • 30 (a)
ManyToMany
Jon44E 36
  • 31 (a)
ManyToMany
Jon65Ai 36
  • 28 (a)
ManyToMany
Jon65Aii 36
  • 30 (a)
ManyToMany
Jon65Aiii 36
  • 28 (a)
ManyToMany
Jon65Aiv 36
  • 27 (a)
ManyToMany
Jon66Ci 36
  • 30 (a)
ManyToMany
Jon66Cii 36
  • 31 (a)
ManyToMany
Jon74E 36
  • 18 (a)
ManyToMany
Jon99Ci 36
  • 28 (a)
ManyToMany
Jon99Cii 36
  • 32 (a)
ManyToMany
Jon99Ciii 36
  • 32 (a)
ManyToMany
Jon99Fi 36
  • 31 (a)
ManyToMany
Jon99Fii 36
  • 31 (a)
ManyToMany
sphinx1 36
  • 20 (a)
ManyToMany
sphinx2 36
  • 21 (a)
ManyToMany
yip7 36
  • 30 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta CLIPD2 35
  • 49.86 (n)
  • 41.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
Species with no ortholog for CTRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTRB1 Gene

ENSEMBL:
Gene Tree for CTRB1 (if available)
TreeFam:
Gene Tree for CTRB1 (if available)

Paralogs for CTRB1 Gene

Paralogs for CTRB1 Gene

genes like me logo Genes that share paralogs with CTRB1: view

Variants for CTRB1 Gene

Sequence variations from dbSNP and Humsavar for CTRB1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_014566 -
VAR_057158 -
rs4243110 -- 75,218,628(+) GTTCC(C/T)GGAGA upstream-variant-2KB
rs8063401 -- 75,219,808(+) AAACA(C/G)ATTGT intron-variant
rs9319479 -- 75,220,321(+) tggga(C/T)tacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTRB1 Gene

Variant ID Type Subtype PubMed ID
nsv833282 CNV Gain+Loss 17160897
nsv7286 OTHER Inversion 18451855
nsv516504 CNV Gain+Loss 19592680
nsv523405 CNV Loss 19592680
dgv2912n71 CNV Loss 21882294
dgv51n16 OTHER Inversion 17901297
esv2504659 OTHER Inversion 19546169
dgv20n50 OTHER Inversion 21212237
esv1000574 OTHER Inversion 20482838
esv1356452 OTHER Inversion 17803354
dgv25n47 OTHER Inversion 21111241
nsv149 OTHER Inversion 15895083
nsv906911 CNV Loss 21882294
nsv482198 CNV Gain 20164927
esv2668023 CNV Deletion 23128226

Variation tolerance for CTRB1 Gene

Gene Damage Index Score: 2.48; 43.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTRB1 Gene

HapMap Linkage Disequilibrium report
CTRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTRB1 Gene

Disorders for CTRB1 Gene

Relevant External Links for CTRB1

Genetic Association Database (GAD)
CTRB1
Human Genome Epidemiology (HuGE) Navigator
CTRB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTRB1

No disorders were found for CTRB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTRB1 Gene

Publications for CTRB1 Gene

  1. Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA. (PMID: 2917002) Tomita N. … Matsubara K. (Biochem. Biophys. Res. Commun. 1989) 2 3 4 67
  2. Genomic cloning and partial characterization of human chymotrypsinogen gene. (PMID: 8186414) Hou D.X. … Soeda E. (Jpn. J. Hum. Genet. 1993) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3
  5. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3

Products for CTRB1 Gene

Sources for CTRB1 Gene

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