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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTRB1 Gene

protein-coding   GIFtS: 57
GCID: GC16P075252

chymotrypsinogen B1


(Previous symbol: CTRB)
 Explore 6 diseases affiliated with
CTRB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CTRB1    

Aliases
for CTRB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chymotrypsinogen B11 2
CTRB1 2 3
EC 3.4.21.13 8
Chymotrypsinogen B2
EC 3.4.218

External Ids:    HGNC: 25211   Entrez Gene: 15042   Ensembl: ENSG000001689257   OMIM: 1188905   UniProtKB: P175383   

Export aliases for CTRB1 gene to outside databases

Previous GC identifers: GC16M066168 GC16P076213 GC16P074991 GC16P075032 GC16P075003 GC16P073810 GC16P061006


Summaries
for CTRB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CTRB1:
The protein encoded by this gene is one of a family of serine proteases that is secreted into the gastrointestinal
tract as an inactive precursor, which is activated by proteolytic cleavage with trypsin. (provided by RefSeq, Oct
2011)




Genomic Views
for CTRB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTRB1 gene promoter:
         NF-1   GATA-3   Tal-1beta   SREBP-1b   GATA-2   GATA-1   PPAR-gamma1   SREBP-1a   PPAR-gamma2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CTRB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CTRB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q23.1

CTRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTRB1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P075252:  view genomic region     (about GC identifiers)

Start:
 75,252,884 bp from pter      End:
 75,258,822 bp from pter
Size:
 5,939 bases      Orientation:
 plus strand

Proteins
for CTRB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CTRB1_HUMAN, P17538 (See protein sequence)
Recommended Name: Chymotrypsinogen B precursor  
Size: 263 amino acids; 27870 Da
Subcellular location: Secreted, extracellular space

Explore the universe of human proteins at neXtProt for CTRB1: NX_P17538

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17538

    • 4/10 DME Specific Peptides for CTRB1 (P17538) (see all 10)
     SGGPLVC  GDSGGPL  FCGGSLI  WPWQVSL 

    CTRB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001897.4  
    ENSEMBL proteins: 
     ENSP00000354294   ENSP00000463301  
    Reactome Protein details: P17538
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: CTRB1
    OriGene Protein Over-expression Lysate: CTRB1
    OriGene Custom Protein Services for CTRB1 
    GenScript Custom Purified and Recombinant Proteins Services for CTRB1
    Novus Biologicals CTRB1 Proteins
    Novus Biologicals CTRB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CTRB1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--


    CTRB1 for ontologies           About GeneDecksing



    CTRB1 Antibody Products: 
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    Novus Biologicals CTRB1 Antibodies
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    Uscn Antibodies for CTRB1
    Search ThermoFisher Antibodies for CTRB1

    Assay Products for CTRB1: 
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    Uscn ELISAs and CLIAs for CTRB1

    Protein Domains /
    Families
    for CTRB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CTRB1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P17538

    ProtoNet protein and cluster: P17538

    2 Blocks protein families:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: CTRB1_HUMAN, P17538
    Similarity: Belongs to the peptidase S1 family
    Similarity: Contains 1 peptidase S1 domain


    Function
    for CTRB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CTRB1_HUMAN, P17538
    Catalytic activity: Preferential cleavage: Tyr- -Xaa, Trp- -Xaa, Phe- -Xaa, Leu- -Xaa

         Genatlas biochemistry entry for CTRB1:
    chymotrypsinogen B1

    Enzyme Numbers (IUBMB): EC 3.4.21.11 2 EC 3.4.212

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTRB1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CTRB1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTRB1 (see all 7)
    OriGene shRNA RFP: CTRB1
    OriGene siRNA: CTRB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTRB1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CTRB1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTRB1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTRB1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CTRB1 (NM_001906)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRB1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CTRB1
    Search LifeMap BioReagents cell lines for CTRB1

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CTRB1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity NAS2917002


    CTRB1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CTRB1:
     Decreased Hepatitis C virus re 

    Animal Models:
         1 MGI phenotypic allele for Ctrb1 (no phenotypes)

    CTRB1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CTRB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Degradation of the extracellular matrix
    		Degradation of the extracellular matrix1.00
    		Activation of Matrix Metalloproteinases0.40
    2Activation of proMMP10
    		Activation of proMMP101.00
    3Protein digestion and absorption
    		Protein digestion and absorption1.00
    4Pancreatic secretion
    		Pancreatic secretion1.00
    5Collagen formation
    		Extracellular matrix organization0.54

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for CTRB1
        Extracellular matrix organization
    Activation of proMMP10
    Degradation of the extracellular matrix
    Activation of Matrix Metalloproteinases


    2         Kegg Pathways  (Kegg details for CTRB1):
        Pancreatic secretion
    Protein digestion and absorption


    CTRB1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTRB1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for CTRB1 (P175383 ENSP000003542944) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050673I2D: score=1 
    RIPK1Q135463I2D: score=1 
    LYPD3ENSP000002443334STRING: ENSP00000244333
    SERPINA1ENSP000003480684STRING: ENSP00000348068
    SERPINF2ENSP000003218534STRING: ENSP00000321853
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS--
    GO:0007586digestion IEA--
    GO:0022617extracellular matrix disassembly TAS--
    GO:0030198extracellular matrix organization TAS--


    CTRB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CTRB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTRB1

    10/16 DrugBank Compounds for CTRB1 (see all 16)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phenylethane Boronic Acid-- 34420-17-2target--17139284 17016423 10592235
    Phosphorylisopropane-- --target--17139284 17016423 10592235
    (2S) N-ACETYL-L-ALANYL-ALPHAL-PHENYLALANYL-CHLOROETHYLKETONE-- --target--10592235
    1,1,1-TRIFLUORO-3-((N-ACETYL)-L-LEUCYLAMIDO)-4-PHENYL-BUTAN-2-ONE(N-ACETYL-L-LEUCYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE)-- --target--10592235
    1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE)-- --target--10592235
    2,4-Dihydroxy-Trans Cinnamic Acid-- 614-86-8target--10592235
    2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDE-- --target--10592235
    3-(4-DIETHYLAMINO-2-HYDROXY-PHENYL)-2-METHYL-PROPIONIC ACID-- --target--10592235
    AprotininBayer A 128 (see all 5)9087-70-1target--15277296
    D-1-(4-CHLOROPHENYL)-2-(ACETAMIDO)ETHANE BORONIC ACID-- --target--10592235

    Search CenterWatch for drugs/clinical trials and news about CTRB1 

    Transcripts
    for CTRB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CTRB1 gene: 
    NM_001906.4  

    Unigene Cluster for CTRB1:

    Chymotrypsinogen B1
    Hs.610926  [show with all ESTs]
    Unigene Representative Sequence: AK124403
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361017(uc002fds.3) ENST00000495583

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTRB1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CTRB1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTRB1 (see all 7)
    OriGene shRNA RFP: CTRB1
    OriGene siRNA: CTRB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTRB1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTRB1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTRB1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CTRB1 (NM_001906)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTRB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTRB1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTRB1
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat CTRB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTRB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTRB1

    Additional cDNA sequence: 

    AK124403.1 BC005385.1 BT007356.1 M24400.1 

    17 DOTS entries:

    DT.99939380  DT.92421819  DT.450700  DT.120666788  DT.120666798  DT.120699706  DT.95356652  DT.100820247 
    DT.100820254  DT.120666789  DT.120699694  DT.100820255  DT.120666783  DT.120666805  DT.120699689  DT.120699704 
    DT.40221398 

    24/154 AceView cDNA sequences (see all 154):

    AA366672 AA366236 BM918884 BI962823 BI769990 BM918560 AA366633 BU785147 
    BM127922 BU948857 BP340253 BQ477380 AA367430 AW583692 AA363464 BQ631995 
    BM352958 AA367006 AA366241 BM505105 BM273014 AW582978 AA367456 AA366666 

    GeneLoc Exon Structure


    Expression
    for CTRB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTRB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CTRB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CTRB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTRB1

    SOURCE GeneReport for Unigene cluster: Hs.610926
        SABiosciences Custom PCR Arrays for CTRB1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTRB1
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CTRB1

    Orthologs
    for CTRB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CTRB1 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    		 --
    		 70(a)
    		 1 → many
    		 Un(54063864-54064613)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 65(a)
    		 possible ortholog
    		 GL343840.1(2123-8439)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC644172 Chymotrypsinogen 2 70.96(n)    BC056849.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb61f072 Danio rerio chymotrypsinogen 2, mRNA (cDNA clone MGC66266 more 74.98(n)    BC055574.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG118363 serine-type endopeptidase 40(a)
    (best of 6)    		   96B20   --


    ENSEMBL Gene Tree for CTRB1 (if available)
    TreeFam Gene Tree for CTRB1 (if available) 

    Paralogs
    for CTRB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTRB1 gene
    CTRL2  CTRC2  CELA2A2  CELA3B2  CELA12  CELA3A2  CELA2B2  CTRB22  
    18/116 SIMAP similar genes for CTRB1 using alignment to 2 protein entries:     CTRB1_HUMAN (see all proteins) (see all similar genes):
    CTRB2    CTRL    FLJ00366    CELA2B    PRSS1    TMPRSS3
    TMPRSS5    CELA2A    CTRC    ELA2A    CELA1    CELA3B
    TMPRSS11D    TMPRSS9    serase-1B    PRSS2    DF    ELA2B

    CTRB1 for paralogs           About GeneDecksing



    Genomic Variants
    for CTRB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/227 NCBI SNPs in CTRB1 are shown (see all 227)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1454545731,2
    		--75250896(+) TTGGAC/GATCAT 1 -- us2k10--------
    rs1905116691,2
    		--75250934(+) CTACTA/GAAAAT 1 -- us2k10--------
    rs1829896951,2
    		--75251044(+) GTGAGC/GTGAGG 1 -- us2k10--------
    rs1862105841,2
    		--75251059(+) ACCCCC/TGCACT 1 -- us2k10--------
    rs572918211,2
    		C,--75251098(+) TCTCA-/GGGGAA 1 -- us2k12Minor allele frequency- G:0.25NA CSA 4
    rs99236581,2
    		C--75251101(+) CAGGGA/GAAAAA 1 -- us2k1 trp30--------
    rs1922878461,2
    		--75251113(+) AAAAAA/GAAAGG 1 -- us2k10--------
    rs1402584621,2
    		--75251181(+) CTTTAC/TAGTTG 1 -- us2k10--------
    rs8895151,2
    		C,F,O,H,--75251299(+) CACTGC/TGTCTT 1 -- us2k128Minor allele frequency- T:0.06NA EA NS WA CSA 2305
    rs1126486341,2
    		--75251345(+) GCCTGT/ACCTGT 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for CTRB1 (75252884 - 75258822 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for CTRB1
         3 CNVs: 49758 49757 4967
         6 Inversions: 29454 0489 103338 37186 37185 29455

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTRB1
    DNA2.0 Custom Variant and Variant Library Synthesis for CTRB1

    Disorders / Diseases
    for CTRB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CTRB1 for disorders           About GeneDecksing

    OMIM gene information: 118890    OMIM disorders: --

    6 diseases for CTRB1:    About MalaCards
    hepatoerythropoietic porphyria    porphyria    choledocholithiasis    pancreatic cancer
    pancreatitis    cholesterol

    1 disease from the University of Copenhagen DISEASES database for CTRB1:
    Hepatoerythropoietic porphyria
    Human Genome Epidemiology (HuGE) Navigator: CTRB1 (1 document)

    Export disorders for CTRB1 gene to outside databases

    Publications
    for CTRB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTRB1 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with CTRB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA. (PubMed id 2917002)1, 2, 3 Tomita N.... Matsubara K. (1989)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Genomic cloning and partial characterization of human chymotrypsinogen gene. (PubMed id 8186414)1, 3 Hou D.X....Soeda E. (1993)
    4. Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1 Dastani Z....Genest J. (2010)
    5. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    6. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    7. Structural analysis and tissue localization of human C4.4A: a protein homologue of the urokinase receptor. (PubMed id 15012588)1 Hansen L.V.... Ploug M. (2004)
    8. Perioperative systemic haemostatic agents. (PubMed id 15277296)7 Mahdy A.M. and Webster N.R. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for CTRB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
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    Genome Databases showing CTRB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1504 HGNC: 2521 AceView: CTRB1 Ensembl:ENSG00000168925 euGenes: HUgn1504
    ECgene: CTRB1 Kegg: 1504 H-InvDB: CTRB1

    Other Databases showing CTRB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CTRB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTRB1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Chymotrypsin

    Intellectual Property
    for CTRB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CTRB1 gene:
    Search GeneIP for patents involving CTRB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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