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Aliases for CTRB1 Gene

Aliases for CTRB1 Gene

  • Chymotrypsinogen B1 2 3
  • EC 4 63
  • CTRB 3 4
  • Chymotrypsinogen B 3
  • EC 3.4.21 63

External Ids for CTRB1 Gene

Previous HGNC Symbols for CTRB1 Gene

  • CTRB

Previous GeneCards Identifiers for CTRB1 Gene

  • GC16M066168
  • GC16P076213
  • GC16P074991
  • GC16P075032
  • GC16P075003
  • GC16P073810
  • GC16P061006

Summaries for CTRB1 Gene

Entrez Gene Summary for CTRB1 Gene

  • The protein encoded by this gene is one of a family of serine proteases that is secreted into the gastrointestinal tract as an inactive precursor, which is activated by proteolytic cleavage with trypsin. [provided by RefSeq, Oct 2011]

GeneCards Summary for CTRB1 Gene

CTRB1 (Chymotrypsinogen B1) is a Protein Coding gene. Among its related pathways are Disease and Degradation of the extracellular matrix. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA2B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTRB1 Gene

Genomics for CTRB1 Gene

Regulatory Elements for CTRB1 Gene

Genomic Location for CTRB1 Gene

75,218,986 bp from pter
75,224,924 bp from pter
5,939 bases
Plus strand

Genomic View for CTRB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTRB1 Gene

Proteins for CTRB1 Gene

  • Protein details for CTRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chymotrypsinogen B
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CTRB1 Gene

    263 amino acids
    Molecular mass:
    27870 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTRB1 Gene

Proteomics data for CTRB1 Gene at MOPED

Post-translational modifications for CTRB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTRB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for CTRB1 Gene

Suggested Antigen Peptide Sequences for CTRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family.
genes like me logo Genes that share domains with CTRB1: view

No data available for Gene Families for CTRB1 Gene

Function for CTRB1 Gene

Molecular function for CTRB1 Gene

GENATLAS Biochemistry:
chymotrypsinogen B1
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Tyr- -Xaa, Trp- -Xaa, Phe- -Xaa, Leu- -Xaa.

Enzyme Numbers (IUBMB) for CTRB1 Gene

Gene Ontology (GO) - Molecular Function for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity NAS 2917002
genes like me logo Genes that share ontologies with CTRB1: view

Phenotypes for CTRB1 Gene

GenomeRNAi human phenotypes for CTRB1:
genes like me logo Genes that share phenotypes with CTRB1: view

Animal Model Products

miRNA for CTRB1 Gene

miRTarBase miRNAs that target CTRB1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTRB1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CTRB1 Gene

Localization for CTRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTRB1 Gene

Secreted, extracellular space.

Subcellular locations from

Jensen Localization Image for CTRB1 Gene COMPARTMENTS Subcellular localization image for CTRB1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CTRB1: view

Pathways for CTRB1 Gene

SuperPathways for CTRB1 Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Degradation of the extracellular matrix
3 Disease
4 Metabolism
5 Pancreatic secretion
genes like me logo Genes that share pathways with CTRB1: view

Interacting Proteins for CTRB1 Gene

Gene Ontology (GO) - Biological Process for CTRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0007586 digestion IEA --
GO:0009235 cobalamin metabolic process TAS --
genes like me logo Genes that share ontologies with CTRB1: view

Drugs for CTRB1 Gene

(16) Drugbank Compounds for CTRB1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • bovine pancreatic trypsin inhibitor
9087-70-1 Target approved, withdrawn
46937104 Target experimental
3082654 Target experimental
124969 Target experimental
2,4-Dihydroxy-Trans Cinnamic Acid
614-86-8 446611 Target experimental
genes like me logo Genes that share compounds with CTRB1: view

Transcripts for CTRB1 Gene

mRNA/cDNA for CTRB1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(154) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CTRB1 Gene

Chymotrypsinogen B1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTRB1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTRB1 Gene

No ASD Table

Relevant External Links for CTRB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTRB1 Gene

mRNA expression in normal human tissues for CTRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTRB1 Gene

This gene is overexpressed in Pancreas (52.9).

Protein differential expression in normal tissues for CTRB1 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CTRB1 Gene

SOURCE GeneReport for Unigene cluster for CTRB1 Gene Hs.610926

genes like me logo Genes that share expressions with CTRB1: view

Expression partners for CTRB1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CTRB1 Gene

Orthologs for CTRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTRB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTRB1 35
  • 87.2 (n)
  • 86.31 (a)
-- 36
  • 69 (a)
(Canis familiaris)
Mammalia CTRB2 35
  • 87.2 (n)
  • 86.69 (a)
-- 36
  • 74 (a)
-- 36
  • 86 (a)
(Pan troglodytes)
Mammalia CTRB1 35
  • 96.7 (n)
  • 97.34 (a)
CTRB1 36
  • 96 (a)
(Mus musculus)
Mammalia Ctrb1 16
Ctrb1 36
  • 85 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
-- 36
  • 74 (a)
-- 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
(Gallus gallus)
Aves -- 36
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733231 35
  • 64.26 (n)
  • 64.26 (a)
LOC394984 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64417 35
(Danio rerio)
Actinopterygii wufb61f07 35
ctrb1 36
  • 38 (a)
zgc:136461 36
  • 68 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1189 35
fruit fly
(Drosophila melanogaster)
Insecta CG10472 37
  • 33 (a)
CG11836 37
  • 40 (a)
CG8172 37
  • 32 (a)
CG8213 37
  • 36 (a)
mas 37
  • 35 (a)
Sb 37
  • 37 (a)
CG31728 35
  • 51.72 (n)
  • 40.95 (a)
CG10469 36
  • 30 (a)
CG10472 36
  • 28 (a)
CG10477 36
  • 27 (a)
CG11529 36
  • 27 (a)
CG18179 36
  • 28 (a)
CG18180 36
  • 27 (a)
CG3088 36
  • 27 (a)
CG6462 36
  • 24 (a)
CG6592 36
  • 17 (a)
CG7542 36
  • 29 (a)
CG8329 36
  • 27 (a)
CG8952 36
  • 30 (a)
Jon25Bi 36
  • 30 (a)
Jon25Bii 36
  • 28 (a)
Jon25Biii 36
  • 30 (a)
Jon44E 36
  • 31 (a)
Jon65Ai 36
  • 28 (a)
Jon65Aii 36
  • 30 (a)
Jon65Aiii 36
  • 28 (a)
Jon65Aiv 36
  • 27 (a)
Jon66Ci 36
  • 30 (a)
Jon66Cii 36
  • 31 (a)
Jon74E 36
  • 18 (a)
Jon99Ci 36
  • 28 (a)
Jon99Cii 36
  • 32 (a)
Jon99Ciii 36
  • 32 (a)
Jon99Fi 36
  • 31 (a)
Jon99Fii 36
  • 31 (a)
sphinx1 36
  • 20 (a)
sphinx2 36
  • 21 (a)
yip7 36
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta CLIPD2 35
  • 49.86 (n)
  • 41.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for CTRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTRB1 Gene

Gene Tree for CTRB1 (if available)
Gene Tree for CTRB1 (if available)

Paralogs for CTRB1 Gene

Paralogs for CTRB1 Gene

genes like me logo Genes that share paralogs with CTRB1: view

Variants for CTRB1 Gene

Sequence variations from dbSNP and Humsavar for CTRB1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs889515 -- 75,217,401(+) CACTG(C/T)GTCTT upstream-variant-2KB
rs1130448 -- 75,219,043(+) TCCCT(C/T)GTGGG synonymous-codon, reference
rs1130452 -- 75,219,050(+) TGGGG(A/G)CCGCC missense, reference
rs2303213 -- 75,224,289(+) TCCTT(C/T)CTGGG intron-variant
rs6564238 -- 75,219,782(+) TTGCA(C/G)ATTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTRB1 Gene

Variant ID Type Subtype PubMed ID
nsv833282 CNV Gain+Loss 17160897
nsv7286 OTHER Inversion 18451855
nsv516504 CNV Gain+Loss 19592680
nsv523405 CNV Loss 19592680
dgv2912n71 CNV Loss 21882294
dgv51n16 OTHER Inversion 17901297
esv2504659 OTHER Inversion 19546169
dgv20n50 OTHER Inversion 21212237
esv1000574 OTHER Inversion 20482838
esv1356452 OTHER Inversion 17803354
dgv25n47 OTHER Inversion 21111241
nsv149 OTHER Inversion 15895083
nsv906911 CNV Loss 21882294
nsv482198 CNV Gain 20164927
esv2668023 CNV Deletion 23128226

Relevant External Links for CTRB1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTRB1 Gene

Disorders for CTRB1 Gene

(1) University of Copenhagen DISEASES for CTRB1 Gene

Relevant External Links for CTRB1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CTRB1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CTRB1 Gene

Publications for CTRB1 Gene

  1. Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA. (PMID: 2917002) Tomita N. … Matsubara K. (Biochem. Biophys. Res. Commun. 1989) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 48
  4. Genomic cloning and partial characterization of human chymotrypsinogen gene. (PMID: 8186414) Hou D.X. … Soeda E. (Jpn. J. Hum. Genet. 1993) 2 3
  5. Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor. (PMID: 10713514) Mac Sweeney A. … Higgins T.M. (Acta Crystallogr. D Biol. Crystallogr. 2000) 3

Products for CTRB1 Gene

Sources for CTRB1 Gene

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