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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTR9 Gene

protein-coding   GIFtS: 49
GCID: GC11P010772

Ctr9, Paf1/RNA polymerase II complex component, homolog...

(Previous name: SH2 domain binding protein 1 (tetratricopeptide repeat...)
(Previous symbol: SH2BP1)
 Explore 2 diseases affiliated with
CTR9 via our new
 Human Malady Compendium 
Biological research products
for CTR9
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ctr9, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae)1 2     SH2 Domain Binding Protein 1 (Tetratricopeptide Repeat Containing)1 2
SH2BP11 2 3 5     SH2 Domain-Binding Protein 12 3
KIAA01551 3 5     P1501
TSBP1 2     RNA Polymerase-Associated Protein CTR9 Homolog2
P150TSP1     TPR-Containing, SH2-Binding Phosphoprotein2

External Ids:    HGNC: 168501   Entrez Gene: 96462   Ensembl: ENSG000001987307   OMIM: 6093665   UniProtKB: Q6PD623   

Export aliases for CTR9 gene to outside databases

Previous GC identifers: GC11P010730 GC11P010731 GC11P010445


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTR9:
CTR9, parafibromin (CDC73; MIM 607393), LEO1 (MIM 610507), and PAF1 (MIM 610506) form the PAF protein complex, which
associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex
(Rozenblatt-Rosen et al., 2005 (PubMed 15632063)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: CTR9_HUMAN, Q6PD62
Function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II
and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates
with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated
forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in
cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C
is involved in hematopoiesis and stimulates transcriptional activity of MLL1; it promotes leukemogenesis though
association with MLL-rearranged oncoproteins, such as MLL-MLLT3/AF9 and MLL-MLLT1/ENL. PAF1C is involved in histone
modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits
the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate
monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be
coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and
poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby
regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation
on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3
'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for
an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT
pathway; may regulate DNA-association of STAT3 (By similarity)

Gene Wiki entry for CTR9


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTR9 gene promoter:
         Elk-1   p53   CUTL1   NF-kappaB   AP-2gamma   NF-kappaB2   AP-2beta   AP-2alpha   NF-kappaB1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTR9 promoter sequence
   Search SABiosciences Chromatin IP Primers for CTR9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTR9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3   Ensembl cytogenetic band:  11p15.3   HGNC cytogenetic band: 11p15.3

CTR9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTR9 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P010772:  view genomic region     (about GC identifiers)

Start:
10,772,534 bp from pter      End:
10,801,290 bp from pter
Size:
28,757 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CTR9_HUMAN, Q6PD62 (See protein sequence)
Recommended Name: RNA polymerase-associated protein CTR9 homolog  
Size: 1173 amino acids; 133502 Da
Subunit: Component of the mammalian PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Interacts
with MLL. Interacts with STAT3 (By similarity)
Subcellular location: Nucleus speckle (By similarity). Note=Found in speckles (By similarity)
Sequence caution: Sequence=BAA09925.2; Type=Erroneous initiation;
Secondary accessions: D3DQV8 Q15015

Explore the universe of human proteins at neXtProt for CTR9: NX_Q6PD62

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6PD62

  • CTR9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055448.1  
    ENSEMBL proteins: 
     ENSP00000355013   ENSP00000431458  

    Human Recombinant Protein Products: 
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    Novus Biologicals CTR9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CTR9

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0016593Cdc73/Paf1 complex IDA--
    GO:0016607nuclear speck IEA--
    GO:0035327transcriptionally active chromatin ISS--


    CTR9 for ontologies           About GeneDecksing



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    Uscn Antibodies for CTR9
    Search ThermoFisher Antibodies for CTR9

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    Uscn ELISAs and CLIAs for CTR9


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CTR9 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011990 TPR-like_helical
     IPR001440 TPR-1
     IPR013105 TPR_2
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q6PD62

    ProtoNet protein and cluster: Q6PD62

    UniProtKB/Swiss-Prot: CTR9_HUMAN, Q6PD62
    Similarity: Contains 16 TPR repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CTR9_HUMAN, Q6PD62
    Function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II
    and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates
    with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated
    forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in
    cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C
    is involved in hematopoiesis and stimulates transcriptional activity of MLL1; it promotes leukemogenesis though
    association with MLL-rearranged oncoproteins, such as MLL-MLLT3/AF9 and MLL-MLLT1/ENL. PAF1C is involved in histone
    modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits
    the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate
    monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be
    coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and
    poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby
    regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylation
    on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3
    'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for
    an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT
    pathway; may regulate DNA-association of STAT3 (By similarity)

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTR9
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CTR9:
    hsa-miR-130a* hsa-miR-513a-3p hsa-miR-23c hsa-miR-4282 hsa-miR-3692 hsa-miR-23b hsa-miR-629 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidCTR9 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTR9 (see all 4)
    OriGene shRNA RFP: CTR9
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTR9

    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTR9 (see all 2)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CTR9 (NM_014633)
    Sino Biological Human cDNA Clone for CTR9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTR9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTR9 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTR9

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0042169SH2 domain binding IEA--


    CTR9 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CTR9:
     Wnt reporter upregulated 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTR9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/139 Interacting proteins for CTR9 (Q6PD621, 2, 3 ENSP000003550134) via UniProtKB, MINT, STRING, and/or I2D (see all 139)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001711endodermal cell fate commitment ISS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007259JAK-STAT cascade ISS--
    GO:0010390histone monoubiquitination IDA16307923


    CTR9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTR9
    Search CenterWatch for drugs/clinical trials and news about CTR9 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CTR9 gene: 
    NM_014633.3  

    Unigene Cluster for CTR9:

    Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
    Hs.725151  [show with all ESTs]
    Unigene Representative Sequence: BC058914
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361367(uc001mja.3) ENST00000524523 ENST00000526874 ENST00000529355
    ENST00000529898

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTR9
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CTR9:
    hsa-miR-130a* hsa-miR-513a-3p hsa-miR-23c hsa-miR-4282 hsa-miR-3692 hsa-miR-23b hsa-miR-629 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidCTR9 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: CTR9
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTR9
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CTR9 (NM_014633)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTR9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTR9 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTR9

    Additional cDNA sequence: 

    AK291794.1 BC014335.1 BC058914.1 D63875.1 

    13 DOTS entries:

    DT.417534  DT.75192574  DT.100792877  DT.86853284  DT.95206804  DT.101956935  DT.120683957  DT.91753426 
    DT.120683953  DT.65287534  DT.75151646  DT.91828414  DT.91926424 

    24/251 AceView cDNA sequences (see all 251):

    AI924726 BU855758 CD370181 AI302523 AA903179 BX090064 BM904284 CA397873 
    AI279164 BQ425108 AI192221 BF197335 T36008 CA306189 BM669477 AW575179 
    BP361862 BM466253 BM542829 BQ955606 AU119376 AI830477 Z36868 AW573224 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CTR9 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19 ^
    SP1:                                                                                -           -                                                               
    SP2:                                      -                                                                                                                     
    SP3:                                                                                -           -     -                                                         
    SP4:                                                                                            -                                                               
    SP5:                                                                                                                                                            

    ExUns: 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25
    SP1:  -                       -                     
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for CTR9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTR9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTCAGATGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CTR9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTR9

    SOURCE GeneReport for Unigene cluster: Hs.725151

    UniProtKB/Swiss-Prot: CTR9_HUMAN, Q6PD62
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for CTR9
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTR9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTR9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CTR9 gene from 10/34 species (see all 34)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctr91 , 5 Ctr9, Paf1/RNA polymerase II complex component, homolog more1, 5 90.15(n)1
    97.87(a)1
      7 (57.98 cM)5
    220831  NM_009431.21  NP_033457.21 
     1110289515 
    chicken
    (Gallus gallus)
    Aves CTR91 Ctr9, Paf1/RNA polymerase II complex component, homolog more 83.5(n)
    95.11(a)
      423035  XM_420968.3  XP_420968.3 
    lizard
    (Anolis carolinensis)
    Reptilia CTR96
    --
    93(a)
    1 ↔ 1
    1(63344352-63368098)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.19442 Xenopus laevis, Similar to likely ortholog of mouse more 79.3(n)    BC043875.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ctr91 Ctr9, Paf1/RNA polymerase II complex component, homolog more 74.74(n)
    86.85(a)
      100036549  NM_001083583.1  NP_001077052.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG24691 CG2469 57.56(n)
    59.56(a)
      38149  NM_176270.1  NP_788448.1 
    worm
    (Caenorhabditis elegans)
    Secernentea B0464.21 Protein B0464.2 51.54(n)
    42.63(a)
      176335  NM_066689.3  NP_499090.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTR91 Ctr9p 43.19(n)
    28.09(a)
      854020   NP_014496.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ELF81 protein early flowering 8 32.18(n)
    12.86(a)
      815177  NM_126631.7  NP_178674.6 
    rice
    (Oryza sativa)
    Liliopsida Os07g04762001 hypothetical protein 46.92(n)
    35.68(a)
      4343217  NM_001066160.1  NP_001059625.1 


    ENSEMBL Gene Tree for CTR9 (if available)
    TreeFam Gene Tree for CTR9 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    7 NCBI SNPs in CTR9 are shown     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs747953741,2
    --10771964(+) TTTTTT/CGAGGT 1 -- us2k12Minor allele frequency- C:0.03NA 122
    rs1401888051,2
    C,--10782923(+) GGATG-/TTAC  
     CAACCCA
    AATGG
    1 -- int10--------
    rs1147770461,2
    F,--10784776(+) TGCTTT/CACTCT 1 -- int11Minor allele frequency- C:0.05WA 118
    rs1409739151,2
    C,--10786023(+) AATCA-/AGTTG 
            
    AGTTG
    1 -- int10--------
    rs2017191031,2
    ----10797284(+) TCTTTA/TTCTTT 1 -- int10--------
    rs1120741491,2
    ----10784711(+) GTTTCC/TACAGC 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs780710131,2
    ----10782930(+) ACCAA-/CCCAAATG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CTR9 (10772534 - 10801290 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CTR9: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTR9
    DNA2.0 Custom Variant and Variant Library Synthesis for CTR9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CTR9 for disorders           About GeneDecksing

    OMIM gene information: 609366    OMIM disorders: --

    2 diseases for CTR9:    About MalaCards
    hematopoiesis    influenza

    Human Genome Epidemiology (HuGE) Navigator: CTR9 (2 documents)

    Export disorders for CTR9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTR9 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with CTR9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T....Nomura N. (1995)
    2. The PAF complex synergizes with MLL fusion proteins a t HOX loci to promote leukemogenesis. (PubMed id 20541477)1, 2 Muntean A.G....Hess J.L. (2010)
    3. The human PAF1 complex acts in chromatin transcriptio n elongation both independently and cooperatively with SII/TFIIS. (PubMed id 20178742)1, 2 Kim J....Roeder R.G. (2010)
    4. A genome-scale RNAi screen for Oct4 modulators define s a role of the Paf1 complex for embryonic stem cell identity. (PubMed id 19345177)1, 2 Ding L....Buchholz F. (2009)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The human PAF complex coordinates transcription with events downstream of RNA synthesis. (PubMed id 16024656)1, 2 Zhu B....Reinberg D. (2005)
    8. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains. (PubMed id 8636124)1, 3 Malek S.N....Desiderio S. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9646 HGNC: 16850 AceView: SH2BP1 Ensembl:ENSG00000198730 euGenes: HUgn9646
    ECgene: CTR9 H-InvDB: CTR9

    (According to HUGE)
    About This Section
    HUGE: KIAA0155

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTR9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CTR9 gene:
    Search GeneIP for patents involving CTR9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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