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Aliases for CTR9 Gene

Aliases for CTR9 Gene

  • CTR9 Homolog, Paf1/RNA Polymerase II Complex Component 2 3 5
  • SH2 Domain Binding Protein 1 (Tetratricopeptide Repeat Containing) 2 3
  • SH2 Domain-Binding Protein 1 3 4
  • SH2BP1 3 4
  • Ctr9, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae) 2
  • Ctr9, Paf1/RNA Polymerase II Complex Component, Homolog 3
  • TPR-Containing, SH2-Binding Phosphoprotein 3
  • KIAA0155 4
  • P150TSP 3
  • P150 3
  • TSBP 3

External Ids for CTR9 Gene

Previous HGNC Symbols for CTR9 Gene

  • SH2BP1

Previous GeneCards Identifiers for CTR9 Gene

  • GC11P010730
  • GC11P010731
  • GC11P010445

Summaries for CTR9 Gene

Entrez Gene Summary for CTR9 Gene

  • CTR9, parafibromin (CDC73; MIM 607393), LEO1 (MIM 610507), and PAF1 (MIM 610506) form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CTR9 Gene

CTR9 (CTR9 Homolog, Paf1/RNA Polymerase II Complex Component) is a Protein Coding gene. GO annotations related to this gene include SH2 domain binding and RNA polymerase II core binding.

UniProtKB/Swiss-Prot for CTR9 Gene

  • Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and Ser-2- and Ser-5-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 Lys-4 (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of Lys-120 of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3 end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 Lys-4 (H3K4me3) and dimethylation on histone H3 Lys-79 (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 Lys-4 (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity).

Gene Wiki entry for CTR9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTR9 Gene

Genomics for CTR9 Gene

Regulatory Elements for CTR9 Gene

Promoters for CTR9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CTR9 on UCSC Golden Path with GeneCards custom track

Genomic Location for CTR9 Gene

Chromosome:
11
Start:
10,750,987 bp from pter
End:
10,779,755 bp from pter
Size:
28,769 bases
Orientation:
Plus strand

Genomic View for CTR9 Gene

Genes around CTR9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTR9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTR9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTR9 Gene

Proteins for CTR9 Gene

  • Protein details for CTR9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PD62-CTR9_HUMAN
    Recommended name:
    RNA polymerase-associated protein CTR9 homolog
    Protein Accession:
    Q6PD62
    Secondary Accessions:
    • D3DQV8
    • Q15015

    Protein attributes for CTR9 Gene

    Size:
    1173 amino acids
    Molecular mass:
    133502 Da
    Quaternary structure:
    • Component of the mammalian PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Interacts with KMT2A/MLL1. Interacts with STAT3 (By similarity).
    SequenceCaution:
    • Sequence=BAA09925.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CTR9 Gene

Proteomics data for CTR9 Gene at MOPED

Post-translational modifications for CTR9 Gene

  • Ubiquitination at Lys 62, Lys 379, Lys 444, Lys 472, Lys 645, Lys 660, Lys 784, and Lys 798
  • Modification sites at PhosphoSitePlus

Other Protein References for CTR9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTR9 Gene

Domains & Families for CTR9 Gene

Protein Domains for CTR9 Gene

Suggested Antigen Peptide Sequences for CTR9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PD62

UniProtKB/Swiss-Prot:

CTR9_HUMAN :
  • Contains 16 TPR repeats.
Similarity:
  • Contains 16 TPR repeats.
genes like me logo Genes that share domains with CTR9: view

Function for CTR9 Gene

Molecular function for CTR9 Gene

UniProtKB/Swiss-Prot Function:
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and Ser-2- and Ser-5-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 Lys-4 (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of Lys-120 of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3 end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 Lys-4 (H3K4me3) and dimethylation on histone H3 Lys-79 (H3K4me3). Required for Hox gene transcription. Required for the trimethylation of histone H3 Lys-4 (H3K4me3) on genes involved in stem cell pluripotency; this function is synergistic with CXXC1 indicative for an involvement of the SET1 complex. Involved in transcriptional regulation of IL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity).
genes like me logo Genes that share phenotypes with CTR9: view

Animal Models for CTR9 Gene

MGI Knock Outs for CTR9:
  • Ctr9 tm1b(EUCOMM)Wtsi

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTR9 Gene

Localization for CTR9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTR9 Gene

Nucleus speckle. Note=Found in speckles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTR9 Gene COMPARTMENTS Subcellular localization image for CTR9 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CTR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CTR9: view

Pathways & Interactions for CTR9 Gene

SuperPathways for CTR9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTR9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0001829 trophectodermal cell differentiation IEA --
GO:0001832 blastocyst growth IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with CTR9: view

No data available for Pathways by source and SIGNOR curated interactions for CTR9 Gene

Drugs & Compounds for CTR9 Gene

No Compound Related Data Available

Transcripts for CTR9 Gene

Unigene Clusters for CTR9 Gene

Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTR9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19 ^
SP1: - -
SP2: -
SP3: - - -
SP4: -
SP5:
SP6:

ExUns: 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24 ^ 25
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for CTR9 Gene

GeneLoc Exon Structure for
CTR9
ECgene alternative splicing isoforms for
CTR9

Expression for CTR9 Gene

mRNA expression in normal human tissues for CTR9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTR9 Gene

This gene is overexpressed in Lung (22.1), Lymph node (7.2), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTR9 Gene



SOURCE GeneReport for Unigene cluster for CTR9 Gene Hs.725151

mRNA Expression by UniProt/SwissProt for CTR9 Gene

Q6PD62-CTR9_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with CTR9: view

Protein tissue co-expression partners for CTR9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CTR9 Gene

Orthologs for CTR9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTR9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTR9 36
  • 99 (a)
OneToOne
CTR9 35
  • 99.7 (n)
  • 99.91 (a)
cow
(Bos Taurus)
Mammalia CTR9 36
  • 95 (a)
OneToOne
CTR9 35
  • 91.33 (n)
  • 97.87 (a)
dog
(Canis familiaris)
Mammalia CTR9 35
  • 93.38 (n)
  • 98.47 (a)
CTR9 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctr9 36
  • 98 (a)
OneToOne
Ctr9 16
Ctr9 35
  • 90.01 (n)
  • 97.87 (a)
oppossum
(Monodelphis domestica)
Mammalia CTR9 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ctr9 35
  • 89.78 (n)
  • 97.95 (a)
chicken
(Gallus gallus)
Aves CTR9 36
  • 95 (a)
OneToOne
CTR9 35
  • 83.02 (n)
  • 94.34 (a)
lizard
(Anolis carolinensis)
Reptilia CTR9 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1944 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ctr9 35
  • 74.5 (n)
  • 88.2 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8444 35
zebrafish
(Danio rerio)
Actinopterygii ctr9 35
  • 74.22 (n)
  • 86.25 (a)
ctr9 36
  • 87 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001559 35
  • 63.62 (n)
  • 72.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2469 36
  • 59 (a)
OneToOne
CG2469 35
  • 63.54 (n)
  • 67.83 (a)
worm
(Caenorhabditis elegans)
Secernentea B0464.2 36
  • 38 (a)
OneToOne
B0464.2 35
  • 52.27 (n)
  • 43.62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTR9 36
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ELF8 35
  • 33.8 (n)
  • 15.29 (a)
rice
(Oryza sativa)
Liliopsida Os07g0476200 35
  • 48.35 (n)
  • 37.5 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9648 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5656 36
  • 71 (a)
OneToOne
Species with no ortholog for CTR9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTR9 Gene

ENSEMBL:
Gene Tree for CTR9 (if available)
TreeFam:
Gene Tree for CTR9 (if available)

Paralogs for CTR9 Gene

No data available for Paralogs for CTR9 Gene

Variants for CTR9 Gene

Sequence variations from dbSNP and Humsavar for CTR9 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2132515 -- 10,761,565(+) TGTTC(A/G)TGCCA intron-variant
rs2132516 -- 10,761,637(+) ATAAA(C/T)AAAAA intron-variant
rs2132517 -- 10,770,436(+) TCTAA(A/G)ATCCT intron-variant
rs2270621 -- 10,755,863(+) TCTTG(A/G)TAATA intron-variant
rs2029891 -- 10,762,338(+) agaaa(A/G)agcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTR9 Gene

Variant ID Type Subtype PubMed ID
nsv832063 CNV Loss 17160897

Variation tolerance for CTR9 Gene

Residual Variation Intolerance Score: 6.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTR9 Gene

HapMap Linkage Disequilibrium report
CTR9
Human Gene Mutation Database (HGMD)
CTR9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTR9 Gene

Disorders for CTR9 Gene

Relevant External Links for CTR9

Genetic Association Database (GAD)
CTR9
Human Genome Epidemiology (HuGE) Navigator
CTR9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTR9

No disorders were found for CTR9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTR9 Gene

Publications for CTR9 Gene

  1. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4 67
  2. p150TSP, a conserved nuclear phosphoprotein that contains multiple tetratricopeptide repeats and binds specifically to SH2 domains. (PMID: 8636124) Malek S.N. … Desiderio S. (J. Biol. Chem. 1996) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for CTR9 Gene

Sources for CTR9 Gene

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