Aliases for CTPS2 Gene
External Ids for CTPS2 Gene
Previous GeneCards Identifiers for CTPS2 Gene
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for CTPS2 Gene
CTPS2 (CTP Synthase 2) is a Protein Coding gene. Diseases associated with CTPS2 include Gliosarcoma. Among its related pathways are Purine metabolism (KEGG) and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. GO annotations related to this gene include hydrolase activity and CTP synthase activity. An important paralog of this gene is CTPS1.
UniProtKB/Swiss-Prot for CTPS2 Gene
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.