Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CTPS2 Gene

Aliases for CTPS2 Gene

  • CTP Synthase 2 2 3
  • EC 6.3.4.2 4 63
  • UTP--Ammonia Ligase 2 4
  • CTP Synthetase 2 4
  • CTP Synthase II 2

External Ids for CTPS2 Gene

Summaries for CTPS2 Gene

Entrez Gene Summary for CTPS2 Gene

  • The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for CTPS2 Gene

CTPS2 (CTP Synthase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. An important paralog of this gene is CTPS1.

UniProtKB/Swiss-Prot for CTPS2 Gene

  • Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.

Gene Wiki entry for CTPS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTPS2 Gene

Genomics for CTPS2 Gene

Genomic Location for CTPS2 Gene

Start:
16,587,999 bp from pter
End:
16,712,979 bp from pter
Size:
124,981 bases
Orientation:
Minus strand

Genomic View for CTPS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTPS2 Gene

Regulatory Elements for CTPS2 Gene

Proteins for CTPS2 Gene

  • Protein details for CTPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRF8-PYRG2_HUMAN
    Recommended name:
    CTP synthase 2
    Protein Accession:
    Q9NRF8
    Secondary Accessions:
    • B3KWM2
    • Q9BRI0
    • Q9H809
    • Q9H8K9

    Protein attributes for CTPS2 Gene

    Size:
    586 amino acids
    Molecular mass:
    65678 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CTPS2 Gene

neXtProt entry for CTPS2 Gene

Proteomics data for CTPS2 Gene at MOPED

Post-translational modifications for CTPS2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys264

Other Protein References for CTPS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CTPS2 Gene

Suggested Antigen Peptide Sequences for CTPS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRF8

UniProtKB/Swiss-Prot:

PYRG2_HUMAN
Domain:
  • Contains 1 glutamine amidotransferase type-1 domain.:
    • Q9NRF8
Family:
  • Belongs to the CTP synthase family.:
    • Q9NRF8
genes like me logo Genes that share domains with CTPS2: view

No data available for Gene Families for CTPS2 Gene

Function for CTPS2 Gene

Molecular function for CTPS2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate
UniProtKB/Swiss-Prot Function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.

Enzyme Numbers (IUBMB) for CTPS2 Gene

Gene Ontology (GO) - Molecular Function for CTPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003883 CTP synthase activity EXP --
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with CTPS2: view

Phenotypes for CTPS2 Gene

MGI mutant phenotypes for CTPS2:
inferred from 1 alleles
GenomeRNAi human phenotypes for CTPS2:
genes like me logo Genes that share phenotypes with CTPS2: view

miRNA for CTPS2 Gene

miRTarBase miRNAs that target CTPS2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CTPS2 Gene

Localization for CTPS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTPS2 Gene COMPARTMENTS Subcellular localization image for CTPS2 gene
Compartment Confidence
cytosol 4
mitochondrion 2
peroxisome 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CTPS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CTPS2 Gene

Pathways for CTPS2 Gene

genes like me logo Genes that share pathways with CTPS2: view

UniProtKB/Swiss-Prot Q9NRF8-PYRG2_HUMAN

  • Pathway: Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2

Gene Ontology (GO) - Biological Process for CTPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006220 pyrimidine nucleotide metabolic process TAS 10899599
GO:0006221 pyrimidine nucleotide biosynthetic process --
GO:0006541 glutamine metabolic process IEA --
GO:0015949 nucleobase-containing small molecule interconversion TAS --
GO:0044210 de novo CTP biosynthetic process IEA --
genes like me logo Genes that share ontologies with CTPS2: view

Compounds for CTPS2 Gene

(10) HMDB Compounds for CTPS2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Ammonia
  • NH3
7664-41-7
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)
65-47-4
Famotidine
  • Amfamox
76824-35-6
genes like me logo Genes that share compounds with CTPS2: view

Transcripts for CTPS2 Gene

Unigene Clusters for CTPS2 Gene

CTP synthase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTPS2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a ·
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6:
SP7: - -

ExUns: 23b · 23c ^ 24a · 24b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CTPS2 Gene

GeneLoc Exon Structure for
CTPS2
ECgene alternative splicing isoforms for
CTPS2

Expression for CTPS2 Gene

mRNA expression in normal human tissues for CTPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTPS2 Gene

SOURCE GeneReport for Unigene cluster for CTPS2 Gene Hs.227049

genes like me logo Genes that share expressions with CTPS2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CTPS2 Gene

Orthologs for CTPS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTPS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTPS2 35
  • 99.32 (n)
  • 99.49 (a)
CTPS2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTPS2 35
  • 92.61 (n)
  • 95.56 (a)
CTPS2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTPS2 35
  • 91.75 (n)
  • 96.25 (a)
CTPS2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctps2 35
  • 87.6 (n)
  • 90.44 (a)
Ctps2 16
Ctps2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTPS2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTPS2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctps2 35
  • 87.6 (n)
  • 90.61 (a)
chicken
(Gallus gallus)
Aves CTPS2 35
  • 77.42 (n)
  • 85.49 (a)
CTPS2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTPS2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctps2 35
  • 73.31 (n)
  • 81.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CTPsyn 36
  • 60 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL320C 35
  • 57.56 (n)
  • 57.14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URA7 35
  • 57.26 (n)
  • 56.43 (a)
URA7 36
  • 54 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05545g 35
  • 58.24 (n)
  • 58.3 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G30820 35
  • 58.72 (n)
  • 58.48 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00261 35
  • 54.36 (n)
  • 55.47 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cts1 35
  • 57.59 (n)
  • 57.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3483 36
  • 61 (a)
OneToMany
Species with no ortholog for CTPS2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CTPS2 Gene

ENSEMBL:
Gene Tree for CTPS2 (if available)
TreeFam:
Gene Tree for CTPS2 (if available)

Paralogs for CTPS2 Gene

Paralogs for CTPS2 Gene

Selected SIMAP similar genes for CTPS2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CTPS2: view

Variants for CTPS2 Gene

Sequence variations from dbSNP and Humsavar for CTPS2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1219 -- 16,588,148(+) AGAAA(C/T)TGACA utr-variant-3-prime
rs16656 -- 16,588,168(+) AAGAC(-/TT)TTCCC utr-variant-3-prime
rs1048392 -- 16,609,633(-) AGGCC(A/G)ATGAA synonymous-codon, reference
rs1127358 -- 16,588,980(-) atttc(A/T)ggcat utr-variant-3-prime
rs1527805 -- 16,590,670(-) GGACT(C/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTPS2 Gene

Variant ID Type Subtype PubMed ID
nsv6814 CNV Loss 18451855
nsv438125 CNV Loss 16468122
nsv6815 CNV Insertion 18451855
nsv6816 CNV Insertion 18451855
esv33814 CNV Gain 17666407
esv33194 CNV Loss 17666407

Relevant External Links for CTPS2 Gene

HapMap Linkage Disequilibrium report
CTPS2
Locus Specific Mutation Databases (LSDB)
CTPS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTPS2 Gene

Disorders for CTPS2 Gene

No disorders were found for CTPS2 Gene.

No data available for UniProtKB/Swiss-Prot for CTPS2 Gene

Publications for CTPS2 Gene

  1. Expression of human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A. (PMID: 16179339) Han G.-S. … Carman G.M. (J. Biol. Chem. 2005) 3 4 23
  2. Identification of a cDNA encoding an isoform of human CTP synthetase. (PMID: 10899599) van Kuilenburg A.B.P. … van Gennip A.H. (Biochim. Biophys. Acta 2000) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for CTPS2 Gene

Sources for CTPS2 Gene

Back to Top

Content