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CTPS1 Gene

protein-coding   GIFtS: 55
GCID: GC01P041445

CTP Synthase 1

(Previous name: CTP synthase)
(Previous symbol: CTPS)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CTP Synthase 11 2     EC 6.3.4.23 8
CTPS1 2 3 5     CTP Synthase1
CTP Synthetase 12 3     Cytidine 5'-Triphosphate Synthetase2
UTP--Ammonia Ligase 12 3     Cytidine 5-Prime Triphosphate Synthetase2

External Ids:    HGNC: 25191   Entrez Gene: 15032   Ensembl: ENSG000001717937   OMIM: 1238605   UniProtKB: P178123   

Export aliases for CTPS1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTPS1 Gene:
The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The
enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth,
development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints
involved in several tumor types (provided by RefSeq, Jul 2008)

GeneCards Summary for CTPS1 Gene:
CTPS1 (CTP synthase 1) is a protein-coding gene. Diseases associated with CTPS1 include pneumonia, and tuberculosis. GO annotations related to this gene include CTP synthase activity. An important paralog of this gene is CTPS2.

UniProtKB/Swiss-Prot: PYRG1_HUMAN, P17812
Function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of
nitrogen

Gene Wiki entry for CTPS1 (CTP synthase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CTPS1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTPS1 promoter sequence
   Search Chromatin IP Primers for CTPS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTPS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.1

CTPS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTPS1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P041445:  view genomic region     (about GC identifiers)

Start:
41,445,007 bp from pter      End:
41,478,235 bp from pter
Size:
33,229 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PYRG1_HUMAN, P17812 (See protein sequence)
Recommended Name: CTP synthase 1  
Size: 591 amino acids; 66690 Da
1 PDB 3D structure from and Proteopedia for CTPS1:
2VO1 (3D)    
Secondary accessions: D3DPW1 Q5VW67 Q96GK6

Explore the universe of human proteins at neXtProt for CTPS1: NX_P17812

Explore proteomics data for CTPS1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys92, Lys100, Lys309, Lys319, Lys460, Lys535
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CTPS1 (P17812) (see all 35)
     HGEVFVL  PHITDAI  TTGKIYQ  YLGKTVQ 


    See CTPS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001896.2  
    ENSEMBL proteins: 
     ENSP00000361704   ENSP00000361699   ENSP00000443098   ENSP00000442646  
    Reactome Protein details: P17812

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR017456 CTP_synthase_N
     IPR027417 P-loop_NTPase
     IPR004468 CTP_synthase
     IPR017926 GATASE

    Graphical View of Domain Structure for InterPro Entry P17812

    ProtoNet protein and cluster: P17812

    1 Blocks protein domain: IPB000991 Glutamine amidotransferase class-I

    UniProtKB/Swiss-Prot: PYRG1_HUMAN, P17812
    Similarity: Belongs to the CTP synthase family
    Similarity: Contains 1 glutamine amidotransferase type-1 domain


    CTPS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PYRG1_HUMAN, P17812
    Function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of
    nitrogen
    Catalytic activity: ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate
    Enzyme regulation: Activated by GTP and inhibited by CTP

         Enzyme Number (IUBMB): EC 6.3.4.21 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003883CTP synthase activity IGI16179339
    GO:0005524ATP binding IEA--
    GO:0016787hydrolase activity ----
         
    CTPS1 for ontologies           About GeneDecksing


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    miRTarBase miRNAs that target CTPS1:
    hsa-mir-1260b (MIRT052704), hsa-mir-186-5p (MIRT044987), hsa-mir-320a (MIRT044690), hsa-let-7b-5p (MIRT032244), hsa-mir-484 (MIRT042068), hsa-mir-122-5p (MIRT023253), hsa-mir-615-3p (MIRT040360)

    Block miRNA regulation of human, mouse, rat CTPS1 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--

    CTPS1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTPS1 About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    Pyrimidine metabolism0.38
    UTP and CTP dephosphorylation II0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
    UTP and CTP de novo biosynthesis0.00
    UTP and CTP dephosphorylation I0.00
    superpathway of pyrimidine ribonucleotides de novo biosynthesis0.00
    4Purine metabolism (REACTOME)
    Metabolism of nucleotides0.42
    Synthesis and interconversion of nucleotide di- and triphosphates0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for CTPS1
        superpathway of pyrimidine ribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    UTP and CTP de novo biosynthesis
    UTP and CTP dephosphorylation II
    UTP and CTP dephosphorylation I


    1 Reactome Pathway for CTPS1
        Synthesis and interconversion of nucleotide di- and triphosphates


    2 Kegg Pathways  (Kegg details for CTPS1):
        Pyrimidine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: PYRG1_HUMAN, P17812
    Pathway: Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2


    CTPS1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTPS1
    Interactions:

        Search GeneGlobe Interaction Network for CTPS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTPS1 (P178122, 3 ENSP000003616994) via UniProtKB, MINT, STRING, and/or I2D (see all 324)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIAA0368Q5VYK32, 3MINT-8173832 I2D: score=2 
    YWHAZP631042, 3MINT-3296359 I2D: score=1 
    ENSG00000206435P305043I2D: score=1 
    ENSG00000206452P305043I2D: score=1 
    HLA-CP305043I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS2113467
    GO:0006221pyrimidine nucleotide biosynthetic process ----
    GO:0006241CTP biosynthetic process IDA16179339
    GO:0006541glutamine metabolic process IEA--
    GO:0015949nucleobase-containing small molecule interconversion TAS--

    CTPS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTPS1 (PYRG1)

    6 Novoseek inferred chemical compound relationships for CTPS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclopentenylcytosine 92.6 5 7554044 (3), 7694793 (1), 9220496 (1)
    ctp 90.6 36 10064135 (6), 15158730 (5), 7554044 (3), 7694793 (2) (see all 12)
    carbamoyl phosphate 68.5 2 8532677 (1), 2347042 (1)
    glutamine 56.2 6 15158730 (4), 2229235 (1), 2347042 (1)
    guanylate 44.8 2 8532677 (1), 2347042 (1)
    atp 11.2 1 2229235 (1)



    CTPS1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CTPS1 gene: 
    NM_001905.2  

    Unigene Cluster for CTPS1:

    CTP synthase 1
    Hs.473087  [show with all ESTs]
    Unigene Representative Sequence: NM_001905
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372621(uc001cgk.4 uc010ojo.2 uc001cgl.4 uc010ojq.2)
    ENST00000470271 ENST00000475060 ENST00000479480 ENST00000372616 ENST00000480420
    ENST00000463285 ENST00000486889 ENST00000497210 ENST00000464283 ENST00000463423
    ENST00000498694 ENST00000543104(uc010ojp.1) ENST00000541520
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      QuantiFast Probe-based Assays in human, mouse, rat CTPS1

    Additional mRNA sequence: 

    AK130549.1 AK225899.1 AK297386.1 AK299122.1 AK303797.1 AK304817.1 BC009408.1 X52142.1 

    22 DOTS entries:

    DT.318826  DT.121329011  DT.101980098  DT.100780851  DT.92408218  DT.92439924  DT.92439909  DT.100721542 
    DT.100028838  DT.100745700  DT.100780850  DT.121329054  DT.92439910  DT.100734930  DT.121329029  DT.121329048 
    DT.40117440  DT.86836834  DT.95098942  DT.95250054  DT.99989428  DT.95341460 

    Selected AceView cDNA sequences (see all 284):

    AI190299 BE328358 BQ688552 AW014511 BX095044 BM543391 BU178343 BU151411 
    AA992545 BE467663 AL041570 AI739330 BC009408 CN482546 H09613 CR608005 
    AA196826 BQ877426 BQ052803 T28502 BP342913 BE293678 BM564377 AK130549 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CTPS1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^
    SP1:                    -     -     -     -                             -                                         -           -                 -               
    SP2:                                                                    -                                         -           -                 -               
    SP3:                                                                                                                                                            
    SP4:                                                                                                              -           -                                 
    SP5:                                                                                                                                            -               

    ExUns: 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c · 23d
    SP1:                                -                                             
    SP2:                                -                                             
    SP3:                                -                                             
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for CTPS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTPS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CTPS1 Expression
    About this image


    CTPS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
    CTPS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTPS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473087
        Custom PCR Arrays for CTPS1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTPS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CTPS1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctps1 , 5 cytidine 5'-triphosphate synthase1, 5 90.13(n)1
    97.8(a)1
      4 (56.52 cM)5
    517971  NM_016748.21  NP_058028.21 
     1205398685 
    chicken
    (Gallus gallus)
    Aves CTPS1 CTP synthase 80.49(n)
    94.25(a)
      419561  XM_004947692.1  XP_004947749.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTPS16
    CTP synthase 1
    92(a)
    1 ↔ 1
    GL343426.1(793660-807215)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044325.12   -- 78.12(n)    BC044325.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NM_199211.12   -- 75.58(n)   322089  NM_199211.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CTPsyn1 CTP synthase 61.77(n)
    66.67(a)
      39645  NM_168606.2  NP_730023.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ctps-11 ctps-1 57.61(n)
    55.98(a)
      189267  NM_074842.2  NP_507243.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes URA7(YBL039C)4
    URA81
    Major CTP synthase isozyme (see also URA8), catalyzes more4
    URA81
    58.18(n)1
    58.48(a)1
      2(145728-143989)4
    8535671  NP_012637.41  8522414 
     NP_009514.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons emb27421 emb2742 58.81(n)
    59.82(a)
      820447  NM_112102.2  NP_187873.1 
    rice
    (Oryza sativa)
    Liliopsida AK070411.12   -- 78.87(n)    AK070411.1 


    ENSEMBL Gene Tree for CTPS1 (if available)
    TreeFam Gene Tree for CTPS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTPS1 gene
    CTPS22  
    1 SIMAP similar gene for CTPS1 using alignment to 3 protein entries:     PYRG1_HUMAN (see all proteins):
    CTPS2

    CTPS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTPS1 (see all 677)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1909545211,2
    --41443279(+) TGAGAC/TAGAGT 1 -- us2k10--------
    rs764568771,2
    C--41443294(+) CTCTGC/TCCAGG 1 -- us2k14Minor allele frequency- T:0.05WA NA EA 360
    rs1481453571,2
    --41443358(+) AAGCAC/TTCCTC 1 -- us2k10--------
    rs2018523581,2
    --41443750(+) ACATC-/TTTTTT 1 -- us2k10--------
    rs1824617271,2
    --41443764(+) TAAAAC/GTCCTT 1 -- us2k10--------
    rs740682911,2
    C--41443793(+) ACTTGT/CGGCAG 1 -- us2k12Minor allele frequency- C:0.05WA 120
    rs1438946071,2
    --41443857(+) CTTTTC/TATGGA 1 -- us2k10--------
    rs1465665091,2
    --41443951(+) TTTCTA/GCAGCT 1 -- us2k10--------
    rs18925531,2
    C--41443980(+) AAAGAA/GAAGCC 1 -- us2k1 trp313Minor allele frequency- G:0.00MN NA WA CSA EA 558
    rs1867038681,2
    --41444157(+) ACTTTA/TAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CTPS1 (41445007 - 41478235 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CTPS1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTPS1
    DNA2.0 Custom Variant and Variant Library Synthesis for CTPS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 123860    OMIM disorders: --

    8 diseases for CTPS1:    
    About MalaCards
    pneumonia    tuberculosis    prostate cancer    prostatitis
    breast cancer    leukemia    cerebritis    malaria


    CTPS1 for disorders           About GeneDecksing


    Export disorders for CTPS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTPS1 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with CTPS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Expression of human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A. (PubMed id 16179339)1, 2 Han G.-S.... Carman G.M. (J. Biol. Chem. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Genomic organization and chromosomal localization of the human CTP synthetase gene (CTPS). (PubMed id 1783378)1, 3 Yamauchi M....Meuth M. (Genomics 1991)
    6. Molecular cloning of the human CTP synthetase gene by functional complementation with purified human metaphase chromosomes. (PubMed id 2113467)1, 2 Yamauchi M.... Meuth M. (EMBO J. 1990)
    7. Cytidine triphosphate synthase activity and mRNA expression in normal human blood cells. (PubMed id 10064135)1, 9 Verschuur A.C....Van Kuilenburg A.B. (Biol. Chem. 1999)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1503 HGNC: 2519 AceView: CTPS Ensembl:ENSG00000171793 euGenes: HUgn1503
    ECgene: CTPS1 Kegg: 1503 H-InvDB: CTPS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CTPS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTPS1 gene:
    Search GeneIP for patents involving CTPS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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