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Aliases for CTNND1 Gene

Aliases for CTNND1 Gene

  • Catenin Delta 1 2 3 5
  • Catenin (Cadherin-Associated Protein), Delta 1 2 3
  • Cadherin-Associated Src Substrate 3 4
  • P120 Catenin 3 4
  • P120(CAS) 3 4
  • P120(CTN) 3 4
  • CAS 3 4
  • KIAA0384 4
  • P120CAS 3
  • P120CTN 3
  • CTNND 3
  • P120 3

External Ids for CTNND1 Gene

Previous HGNC Symbols for CTNND1 Gene

  • CTNND

Previous GeneCards Identifiers for CTNND1 Gene

  • GC11P059875
  • GC11P059042
  • GC11P057304
  • GC11P057237
  • GC11P057286
  • GC11P057240
  • GC11P057287
  • GC11P057531
  • GC11P053877

Summaries for CTNND1 Gene

Entrez Gene Summary for CTNND1 Gene

  • This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for CTNND1 Gene

CTNND1 (Catenin Delta 1) is a Protein Coding gene. Diseases associated with CTNND1 include pulmonary sclerosing hemangioma and sclerosing hemangioma. Among its related pathways are Adherens junction and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. GO annotations related to this gene include binding and receptor binding. An important paralog of this gene is PKP4.

UniProtKB/Swiss-Prot for CTNND1 Gene

  • Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.

Gene Wiki entry for CTNND1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTNND1 Gene

Genomics for CTNND1 Gene

Regulatory Elements for CTNND1 Gene

Enhancers for CTNND1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CTNND1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CTNND1 Gene

Chromosome:
11
Start:
57,753,243 bp from pter
End:
57,819,546 bp from pter
Size:
66,304 bases
Orientation:
Plus strand

Genomic View for CTNND1 Gene

Genes around CTNND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTNND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTNND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTNND1 Gene

Proteins for CTNND1 Gene

neXtProt entry for CTNND1 Gene

Proteomics data for CTNND1 Gene at MOPED

Post-translational modifications for CTNND1 Gene

  • Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ.
  • Ubiquitination at Lys 710
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CTNND1 Gene

Domains & Families for CTNND1 Gene

Gene Families for CTNND1 Gene

Protein Domains for CTNND1 Gene

Suggested Antigen Peptide Sequences for CTNND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60716

UniProtKB/Swiss-Prot:

CTND1_HUMAN :
  • A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
  • Belongs to the beta-catenin family.
  • Contains 10 ARM repeats.
Domain:
  • A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.
  • ARM repeats 1 to 5 mediate interaction with cadherins.
Family:
  • Belongs to the beta-catenin family.
Similarity:
  • Contains 10 ARM repeats.
genes like me logo Genes that share domains with CTNND1: view

Function for CTNND1 Gene

Molecular function for CTNND1 Gene

GENATLAS Biochemistry:
catenin delta 1,120kDa,multiple isoforms,desmosomal plaque component regulating cell adhesion (component of E cadherin multiprotein complex, homologous to Drosophila Armadillo segment polarity gene)
UniProtKB/Swiss-Prot Function:
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
UniProtKB/Swiss-Prot Induction:
Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure.

Gene Ontology (GO) - Molecular Function for CTNND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 19332538
genes like me logo Genes that share ontologies with CTNND1: view
genes like me logo Genes that share phenotypes with CTNND1: view

miRNA for CTNND1 Gene

miRTarBase miRNAs that target CTNND1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTNND1 Gene

Localization for CTNND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTNND1 Gene

Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. Isoforms 4A and 1AB are excluded from the nucleus. {ECO:0000250}.
Isoform 1A: Nucleus.
Isoform 2A: Nucleus.
Isoform 3A: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTNND1 Gene COMPARTMENTS Subcellular localization image for CTNND1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for CTNND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17047063
GO:0005911 cell-cell junction IDA 12370829
GO:0030496 midbody IDA 15166316
genes like me logo Genes that share ontologies with CTNND1: view

Pathways & Interactions for CTNND1 Gene

genes like me logo Genes that share pathways with CTNND1: view

SIGNOR curated interactions for CTNND1 Gene

Activates:
Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CTNND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0034332 adherens junction organization TAS --
GO:0045216 cell-cell junction organization TAS --
genes like me logo Genes that share ontologies with CTNND1: view

Drugs & Compounds for CTNND1 Gene

(13) Drugs for CTNND1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CTNND1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CTNND1: view

Transcripts for CTNND1 Gene

Unigene Clusters for CTNND1 Gene

Catenin (cadherin-associated protein), delta 1:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTNND1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: - -
SP7: - - -
SP8: - - - - -
SP9: - - - - - -
SP10: - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - -
SP15: - - - - - -
SP16: - - - - - - - - -
SP17: - - - - - - - - - - -
SP18: - - - - - - - - - - -
SP19: - - - - - - - - - - -
SP20: - - - - - - - - -
SP21:
SP22: - -
SP23:
SP24: - -
SP25:
SP26:
SP27:

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8: - - -
SP9: - - -
SP10: - - -
SP11: - -
SP12: - - -
SP13: - - -
SP14: - - -
SP15: - - -
SP16: - - -
SP17: - -
SP18: - - -
SP19: - - -
SP20: - - -
SP21:
SP22:
SP23: -
SP24:
SP25:
SP26:
SP27:

Relevant External Links for CTNND1 Gene

GeneLoc Exon Structure for
CTNND1
ECgene alternative splicing isoforms for
CTNND1

Expression for CTNND1 Gene

mRNA expression in normal human tissues for CTNND1 Gene

Protein differential expression in normal tissues from HIPED for CTNND1 Gene

This gene is overexpressed in Breast (9.9) and Islet of Langerhans (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CTNND1 Gene



SOURCE GeneReport for Unigene cluster for CTNND1 Gene Hs.166011

mRNA Expression by UniProt/SwissProt for CTNND1 Gene

O60716-CTND1_HUMAN
Tissue specificity: Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.
genes like me logo Genes that share expression patterns with CTNND1: view

Protein tissue co-expression partners for CTNND1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CTNND1 Gene

Orthologs for CTNND1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTNND1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTNND1 35
  • 87.99 (n)
  • 95.62 (a)
CTNND1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTNND1 35
  • 93.83 (n)
  • 98.04 (a)
ZDHHC5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctnnd1 35
  • 90.81 (n)
  • 97.76 (a)
Ctnnd1 16
Ctnnd1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTNND1 35
  • 99.72 (n)
  • 99.79 (a)
CTNND1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctnnd1 35
  • 91.61 (n)
  • 98.06 (a)
oppossum
(Monodelphis domestica)
Mammalia CTNND1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves CTNND1 35
  • 78.05 (n)
  • 86.34 (a)
CTNND1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTNND1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctnnd1 35
  • 60.46 (n)
  • 60.42 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100334714 35
  • 62.72 (n)
  • 65.2 (a)
ctnnd1 36
  • 60 (a)
OneToMany
ctnnd1 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta p120ctn 37
  • 43 (a)
p120ctn 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea jac-1 37
  • 32 (a)
jac-1 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for CTNND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTNND1 Gene

ENSEMBL:
Gene Tree for CTNND1 (if available)
TreeFam:
Gene Tree for CTNND1 (if available)

Paralogs for CTNND1 Gene

Paralogs for CTNND1 Gene

(6) SIMAP similar genes for CTNND1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CTNND1: view

Variants for CTNND1 Gene

Sequence variations from dbSNP and Humsavar for CTNND1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_020929 -
VAR_020930 -
VAR_020931 -
VAR_038255 -
rs368606036 -- 57,806,247(+) GTGGT(-/GGTGGTGGTGGT)ATCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTNND1 Gene

Variant ID Type Subtype PubMed ID
nsv832164 CNV Loss 17160897
nsv508633 CNV Loss 20534489
nsv327 CNV Loss 18451855

Variation tolerance for CTNND1 Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.13; 69.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTNND1 Gene

HapMap Linkage Disequilibrium report
CTNND1
Human Gene Mutation Database (HGMD)
CTNND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTNND1 Gene

Disorders for CTNND1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CTNND1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pulmonary sclerosing hemangioma
  • pneumocytoma
sclerosing hemangioma
  • cutaneous fibrous histiocytoma
colon adenocarcinoma
  • adenocarcinoma of colon
hemangioma of lung
  • pulmonary hemangioma
epithelial malignant thymoma
  • squamoid thymoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CTNND1

Tumor Gene Database (TGDB):
CTNND1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTNND1
genes like me logo Genes that share disorders with CTNND1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTNND1 Gene

Publications for CTNND1 Gene

  1. Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells. (PMID: 14699141) Kondapalli J. … Albuquerque M.L.C. (J. Biol. Chem. 2004) 3 4 23 67
  2. The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns). (PMID: 8808291) Reynolds A.B. … Daniel J.M. (Genomics 1996) 2 3 23
  3. Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn. (PMID: 19615783) Dai S.D. … Wang E.H. (Lung Cancer 2010) 3 23
  4. Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer. (PMID: 20118984) Cheung L.W. … Wong A.S. (Oncogene 2010) 3 23
  5. Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. (PMID: 20371349) Ishiyama N. … Ikura M. (Cell 2010) 3 23

Products for CTNND1 Gene

Sources for CTNND1 Gene

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