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CTNND1 Gene

protein-coding   GIFtS: 66
GCID: GC11P057531

Catenin (Cadherin-Associated Protein), Delta 1


(Previous symbol: CTNND)
Pneumococci & Pneumococcal Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Catenin (Cadherin-Associated Protein), Delta 11 2     Catenin Delta-12
CTNND1 2 5     p1202
Cadherin-Associated Src Substrate2 3     p120(CAS)2
CAS2 3     p120(CTN)2
P120 Catenin2 3     KIAA03843
P120CAS2     p120(cas)3
P120CTN2     p120(ctn)3

External Ids:    HGNC: 25151   Entrez Gene: 15002   Ensembl: ENSG000001985617   OMIM: 6010455   UniProtKB: O607163   

Export aliases for CTNND1 gene to outside databases

Previous GC identifers: GC11P059875 GC11P059042 GC11P057780 GC11P057304 GC11P057237 GC11P057286 GC11P057240 GC11P057287 GC11P053877


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTNND1 Gene:
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal
transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms
being translated. Not all of the full-length natures of the described transcript variants have been determined.
Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related
transmembrane protein 2 (TMX2) gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for CTNND1 Gene:
CTNND1 (catenin (cadherin-associated protein), delta 1) is a protein-coding gene. Diseases associated with CTNND1 include sarcomatoid renal cell carcinoma, and lobular neoplasia. GO annotations related to this gene include protein phosphatase binding and receptor binding. An important paralog of this gene is PKP1.

UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716
Function: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes
of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both
C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC
and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2
C-terminal cleavage

Gene Wiki entry for CTNND1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTNND1 gene promoter:
         STAT5B   Pax-5   POU6F1 (c2)   STAT5A   Nkx2-5   LCR-F1   Evi-1   Gfi-1   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTNND1 promoter sequence
   Search Chromatin IP Primers for CTNND1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTNND1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q11   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

CTNND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTNND1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P057531:  view genomic region     (about GC identifiers)

Start:
57,520,715 bp from pter      End:
57,587,018 bp from pter
Size:
66,304 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716 (See protein sequence)
Recommended Name: Catenin delta-1  
Size: 968 amino acids; 108170 Da
Subunit: Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin,
beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin.
Interacts with ZBTB33. Interacts with GLIS2. Interacts with NANOS1 (via N-terminal region). Interacts with FER
Sequence caution: Sequence=BAA20838.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for CTNND1:
3L6X (3D)        3L6Y (3D)    
Secondary accessions: A8K939 O15088 O60713 O60714 O60715 O60935 Q6DHZ7 Q6RBX8 Q9UP71 Q9UP72
Q9UP73
Alternative splicing, Alternative initiation: 32 isoforms:  O60716-1   O60716-2   O60716-3   O60716-4   O60716-5   O60716-6   O60716-7   O60716-8   
O60716-9   O60716-10   O60716-11   O60716-12   O60716-13   O60716-14   O60716-15   O60716-16   
O60716-17   O60716-18   O60716-19   O60716-20   O60716-21   O60716-22   O60716-23   O60716-24   
O60716-25   O60716-26   O60716-27   O60716-28   O60716-29   O60716-30   O60716-31   O60716-32   
(Contains a phosphothreonine at position 566)

Explore the universe of human proteins at neXtProt for CTNND1: NX_O60716

Explore proteomics data for CTNND1 at MOPED

Post-translational modifications: 

  • Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated
    by PTPRJ1
  • Ubiquitination2 at Lys710
  • Modification sites at PhosphoSitePlus

  • See CTNND1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (22 alternative transcripts): 
    NP_001078927.1  NP_001078928.1  NP_001078929.1  NP_001078930.1  NP_001078931.1  NP_001078932.1  NP_001078933.1  NP_001078934.1  
    NP_001078935.1  NP_001078936.1  NP_001078937.1  NP_001078938.1  NP_001193812.1  NP_001193813.1  NP_001193814.1  NP_001193815.1  
    NP_001193816.1  NP_001193817.1  NP_001193818.1  NP_001193819.1  NP_001193820.1  NP_001322.1  

    ENSEMBL proteins: 
     ENSP00000436543   ENSP00000434808   ENSP00000435242   ENSP00000436323   ENSP00000409930  
     ENSP00000382004   ENSP00000354785   ENSP00000354823   ENSP00000432075   ENSP00000437156  
     ENSP00000351527   ENSP00000434949   ENSP00000437051   ENSP00000435379   ENSP00000432243  
     ENSP00000436744   ENSP00000413586   ENSP00000434900   ENSP00000435266   ENSP00000432623  
     ENSP00000433158   ENSP00000435494   ENSP00000434672   ENSP00000433276   ENSP00000433334  
     ENSP00000437327   ENSP00000403518   ENSP00000434017   ENSP00000435789   ENSP00000432041  
     ENSP00000432299   ENSP00000431600   ENSP00000434202   ENSP00000431208   ENSP00000381996  
     ENSP00000353902   ENSP00000354907  
    Reactome Protein details: O60716

    CTNND1 Human Recombinant Protein Products:

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    Novus Biologicals CTNND1 Protein
    Novus Biologicals CTNND1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

    CTNND1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CTNND1
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    Abcam antibodies for CTNND1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CTNND1
    LSBio Antibodies in human, mouse, rat for CTNND1

    CTNND1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CTNND1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CTNND1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARMC: Armadillo repeat containing

    5 InterPro protein domains:
     IPR028439 Catenin_d1
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR028435 Plakophilin/d_Catenin
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O60716

    ProtoNet protein and cluster: O60716

    1 Blocks protein domain: IPB000225 Armadillo repeat

    UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716
    Domain: A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted
    Domain: ARM repeats 1 to 5 mediate interaction with cadherins
    Similarity: Belongs to the beta-catenin family
    Similarity: Contains 10 ARM repeats


    CTNND1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTND1_HUMAN, O60716
    Function: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes
    of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both
    C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC
    and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2
    C-terminal cleavage
    Induction: Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress,
    which enhances wound closure

         Genatlas biochemistry entry for CTNND1:
    catenin delta 1,120kDa,multiple isoforms,desmosomal plaque component regulating cell adhesion (component of E
    cadherin multiprotein complex, homologous to Drosophila Armadillo segment polarity gene)

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI19332538
    GO:0005488binding ----
    GO:0005515protein binding IPI12370829
    GO:0019901protein kinase binding IEA--
    GO:0019903protein phosphatase binding IEA--
         
    CTNND1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CTNND1:
     Decreased focal adhesion (FA)   Stronger migration 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ctnnd1):
     cellular  digestive/alimentary  endocrine/exocrine gland  integument  mortality/aging 
     nervous system  renal/urinary system  tumorigenesis  vision/eye 

    CTNND1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTNND1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTNND1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTNND1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTNND1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CTNND1:
    hsa-mir-124-3p (MIRT002658), hsa-mir-1229-3p (MIRT036283), hsa-mir-30a-5p (MIRT028638), hsa-mir-331-3p (MIRT043271), hsa-mir-324-3p (MIRT042823), hsa-mir-335-5p (MIRT019044), hsa-mir-615-3p (MIRT040176), hsa-mir-10a-5p (MIRT047675)

    Block miRNA regulation of human, mouse, rat CTNND1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTNND1 (see all 105):
    hsa-miR-579 hsa-miR-3678-3p hsa-miR-361-5p hsa-miR-218-1* hsa-miR-629* hsa-miR-4325 hsa-miR-3613-3p hsa-miR-4293
    SwitchGear 3'UTR luciferase reporter plasmidCTNND1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CTNND1
    Predesigned siRNA for gene silencing in human, mouse, rat CTNND1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CTNND1

    Clone
    Products:
         
    OriGene clones in human, mouse for CTNND1 (see all 77)
    OriGene ORF clones in mouse, rat for CTNND1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 13): CTNND1 (NM_001085469)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTNND1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTNND1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CTNND1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CTNND1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNND1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTND1_HUMAN, O60716: Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear
    translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of
    cell-cell contact to the cytoplasm. Isoforms 4A and 1AB are excluded from the nucleus
    CTND1_HUMAN, O60716: Isoform 1A: Nucleus
    CTND1_HUMAN, O60716: Isoform 2A: Nucleus
    CTND1_HUMAN, O60716: Isoform 3A: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol3
    cytoskeleton2

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA17047063
    GO:0005829cytosol IMP--
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction IDA12370829

    CTNND1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTNND1 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Adherens junctions interactions0.49
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    3Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway and Pluripotency0.55
    4ERK Signaling
    Molecular Mechanisms of Cancer0.51
    5Integrin Pathway
    Transendothelial Migration of Leukocytes0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CTNND1 (see all 6)
        Sertoli-Sertoli Cell Junction Dynamics
    Remodeling of Adherens Junctions
    Molecular Mechanisms of Cancer
    Germ Cell-Sertoli Cell Junction Dynamics
    Transendothelial Migration of Leukocytes

    3 Cell Signaling Technology (CST) Pathways for CTNND1
        Wnt / Hedgehog / Notch
    Cytoskeletal Signaling
    Adhesion

    3 GeneGo (Thomson Reuters) Pathways for CTNND1
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Cadherin-mediated cell adhesion

    Selected BioSystems Pathways for CTNND1 (see all 8)
        EGFR1 Signaling Pathway
    Wnt Signaling Pathway and Pluripotency
    N-cadherin signaling events
    E-cadherin signaling in keratinocytes
    Arf6 trafficking events

    1 Reactome Pathway for CTNND1
        Adherens junctions interactions


    3 Kegg Pathways  (Kegg details for CTNND1):
        Rap1 signaling pathway
    Adherens junction
    Leukocyte transendothelial migration


    CTNND1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTNND1: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Adherens Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CTNND1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTNND1 (O607161, 2, 3 ENSP000003820044) via UniProtKB, MINT, STRING, and/or I2D (see all 679)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FRMD5Q7Z6J61, 2EBI-701927,EBI-727282 MINT-8385411 MINT-8385398 MINT-8385383
    YWHAEP622582, 3MINT-7947479 I2D: score=1 
    PTPRJQ129131, 2, 3, ENSP000004000104EBI-701927,EBI-2264500 MINT-7026794 MINT-7026805 MINT-7026816 MINT-7026783 MINT-7026899 I2D: score=4 STRING: ENSP00000400010
    CDH1P128302, 3, ENSP000002617694MINT-8385411 I2D: score=5 STRING: ENSP00000261769
    ZBTB33Q86T243, ENSP000003141534I2D: score=6 STRING: ENSP00000314153
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001738morphogenesis of a polarized epithelium IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007155cell adhesion NAS8808291
    GO:0007420brain development IEA--

    CTNND1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTNND1 (CTND1)

    Selected Novoseek inferred chemical compound relationships for CTNND1 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 66.9 128 1851549 (7), 11171320 (5), 7876318 (3), 10753936 (3) (see all 62)
    phosphotyrosine 42.9 6 14699166 (1), 9378757 (1), 9742093 (1), 11433418 (1)
    threonine 30.5 20 17719574 (5), 16935280 (4), 10024525 (2), 15684660 (2) (see all 9)
    nocodazole 24.2 3 17584295 (2), 14676216 (1)
    serine 19.4 17 17719574 (5), 10024525 (2), 10657259 (2), 10409703 (1) (see all 10)
    vegf 8.28 6 10657259 (3), 19755858 (1), 12771128 (1), 9625748 (1)
    phenylalanine 5.66 5 11171320 (1), 15800180 (1), 11382764 (1)
    oxygen 4.24 2 19422420 (1)
    lipid 0 2 10708762 (1), 19615358 (1)
    calcium 0 20 18578707 (8), 19162191 (2), 14528017 (1), 17719574 (1) (see all 5)



    CTNND1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CTNND1 gene (22 alternative transcripts): 
    NM_001085458.1  NM_001085459.1  NM_001085460.1  NM_001085461.1  NM_001085462.1  NM_001085463.1  NM_001085464.1  NM_001085465.1  
    NM_001085466.1  NM_001085467.1  NM_001085468.1  NM_001085469.1  NM_001206883.1  NM_001206884.1  NM_001206885.1  NM_001206886.1  
    NM_001206887.1  NM_001206888.1  NM_001206889.1  NM_001206890.1  NM_001206891.1  NM_001331.2  

    Unigene Cluster for CTNND1:

    Catenin (cadherin-associated protein), delta 1
    Hs.166011  [show with all ESTs]
    Unigene Representative Sequence: NM_001085458
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 40):
    ENST00000524630(uc021qjk.1) ENST00000529919 ENST00000533189 ENST00000529526
    ENST00000426142 ENST00000399050(uc001nlf.2 uc001nmc.4) ENST00000361391
    ENST00000361332(uc001nme.4) ENST00000532463 ENST00000529986 ENST00000358694
    ENST00000532787 ENST00000533667 ENST00000532649 ENST00000528621 ENST00000530748
    ENST00000428599 ENST00000527467(uc001nlx.4)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CTNND1 (see all 105):
    hsa-miR-579 hsa-miR-3678-3p hsa-miR-361-5p hsa-miR-218-1* hsa-miR-629* hsa-miR-4325 hsa-miR-3613-3p hsa-miR-4293
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CTNND1
    Clone
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    OriGene clones in human, mouse for CTNND1 (see all 77)
    OriGene ORF clones in mouse, rat for CTNND1
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    GenScript: all cDNA clones in your preferred vector (see all 13): CTNND1 (NM_001085469)
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    Additional mRNA sequence: 

    AF062317.1 AF062318.1 AF062319.1 AF062320.1 AF062321.1 AF062322.1 AF062323.1 AF062324.1 
    AF062325.1 AF062326.1 AF062327.1 AF062328.1 AF062329.1 AF062330.1 AF062331.1 AF062332.1 
    AF062333.1 AF062334.1 AF062335.1 AF062336.1 AF062337.1 AF062338.1 AF062339.1 AF062340.1 
    AF062341.1 AF062342.1 AF062343.1 AF062344.1 AK292554.1 BC010501.1 BC057224.1 BC075795.1 
    BT007333.1 CR749275.1 NR_037646.1 

    Selected DOTS entries (see all 60):

    DT.120747381  DT.95374970  DT.95188844  DT.95374961  DT.75158674  DT.95148870  DT.97864468  DT.100891143 
    DT.92005448  DT.97782379  DT.97807476  DT.100891158  DT.120747228  DT.120747252  DT.97797665  DT.100891153 
    DT.95374968  DT.92455619  DT.75146926  DT.100891166  DT.120747242  DT.100891154  DT.92455647  DT.100709750 

    Selected AceView cDNA sequences (see all 274):

    BM770215 CR604249 BM846899 BI771847 BM767335 BX951058 CR614298 CD653508 
    AV654437 AA663480 AA565434 CR599752 BM552065 CN482544 AI802281 BI834249 
    BM801622 BQ947990 AI888315 BM766780 CR590068 BU541569 AI902877 BQ957743 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CTNND1 (see all 27)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
    SP1:                                                                                                              -                       -                     
    SP2:                                                                          -     -                             -                       -                     
    SP3:                                                                          -     -           -                 -                       -                     
    SP4:                                                                          -     -     -     -                 -                       -                     
    SP5:                                                                                                              -                       -                     

    ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b
    SP1:                                                  -                             -               
    SP2:                                                  -                       -     -               
    SP3:                                                  -                       -     -               
    SP4:                                                  -                             -               
    SP5:                                                  -                       -     -               


    ECgene alternative splicing isoforms for CTNND1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CTNND1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACTGGAGT
    CTNND1 Expression
    About this image

    CTNND1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTNND1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.166011

    UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716
    Tissue specificity: Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long
    isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected
    in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or
    melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon,
    intestine and prostate, but lost in several tumor tissues derived from these organs

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTNND1: 
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNND1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CTNND1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctnnd11 , 5 catenin (cadherin associated protein), delta 11, 5 90.81(n)1
    97.76(a)1
      2 (49.45 cM)5
    123881  NM_007615.41  NP_031641.21 
     846000715 
    chicken
    (Gallus gallus)
    Aves CTNND11 catenin (cadherin-associated protein), delta 1 78.05(n)
    86.34(a)
      428852  XM_004941496.1  XP_004941553.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTNND16
    catenin (cadherin-associated protein), delta 1
    87(a)
    1 ↔ 1
    1(91371679-91411752)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ctnnd11 catenin (cadherin-associated protein), delta 1 60.46(n)
    60.42(a)
      100101665  NM_001126073.1  NP_001119545.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003347141 catenin delta-1-like 62.72(n)
    65.2(a)
      100334714  XM_005160259.1  XP_005160316.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta p120ctn3   -- 43(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea jac-13   -- 32(a)   IV(15998290-16017650)   --


    ENSEMBL Gene Tree for CTNND1 (if available)
    TreeFam Gene Tree for CTNND1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTNND1 gene
    PKP12  PKP22  PKP32  CTNND22  ARVCF2  PKP42  
    6 SIMAP similar genes for CTNND1 using alignment to 7 protein entries:     CTND1_HUMAN (see all proteins):
    DKFZp781O2021    ps1ly2h-25    ARVCF    PKP4    CTNND2    PKP1

    CTNND1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTNND1 (see all 1056)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1921324361,2
    Cuntested157459879(+) CCCACA/G/TCTCAA 22 -- int10--------
    rs1409390941,2
    --57447737(+) CTGGGC/TTCAAG 22 -- us2k10--------
    rs1872521371,2
    --57447934(+) ACTGTA/GCCCAG 22 -- us2k10--------
    rs1916893841,2
    --57447945(+) CCAAGG/TTTTCG 22 -- us2k10--------
    rs1816140991,2
    --57447969(+) GATTTG/TGATAA 22 -- us2k10--------
    rs1447973201,2
    C--57448050(+) TTTGAC/TTCATC 22 -- us2k10--------
    rs1475378071,2
    --57448191(+) ATACCC/GCAATA 22 -- us2k10--------
    rs1401509611,2
    --57448221(+) TGTAAA/GAAGAG 22 -- us2k10--------
    rs1855105721,2
    --57448274(+) AATAAA/CATGTT 22 -- us2k10--------
    rs1900734921,2
    --57448372(+) CCTCCC/TCGGTT 22 -- us2k10--------

    HapMap Linkage Disequilibrium report for CTNND1 (57520715 - 57587018 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CTNND1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832164CNV Loss17160897
    nsv327CNV Loss18451855
    nsv508633CNV Loss20534489

    Human Gene Mutation Database (HGMD): CTNND1
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing CTNND1:
    Lung Cancer
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing CTNND1
    DNA2.0 Custom Variant and Variant Library Synthesis for CTNND1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601045    OMIM disorders: --

    Selected diseases for CTNND1 (see all 47):    
    About MalaCards
    sarcomatoid renal cell carcinoma    lobular neoplasia    pulmonary sclerosing hemangioma    sclerosing hemangioma
    crescentic glomerulonephritis    hemangioma    cutaneous malignant melanoma    colon adenocarcinoma
    prostate adenocarcinoma    glomerulonephritis    familial adenomatous polyposis    pemphigus
    thymoma    rabies    choriocarcinoma    endometrial carcinoma
    wiskott-aldrich syndrome    pancreatic cancer    adenocarcinoma    renal cell carcinoma

    2 diseases from the University of Copenhagen DISEASES database for CTNND1:
    Invasive lobular carcinoma     Lobular neoplasia

    CTNND1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for CTNND1 gene (see all 40)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma lobular 56.8 5 20078969 (2), 17143261 (1), 20510078 (1), 17325485 (1)
    tumors 35.5 83 17325485 (6), 16231374 (5), 18595142 (4), 17030444 (3) (see all 36)
    metastasis 32.2 26 19615783 (4), 10397474 (3), 18595142 (2), 16231374 (2) (see all 13)
    carcinoma 28.3 15 7542384 (2), 7876318 (1), 8653709 (1), 19551809 (1) (see all 10)
    cancer 28.3 28 17942908 (2), 11755823 (2), 15489912 (2), 10725216 (2) (see all 17)
    carcinoma ductal 27.3 6 20078969 (2), 9422525 (1), 20510078 (1), 17721269 (1)
    prostate carcinoma 24.9 10 14748788 (4), 7542384 (2), 10687853 (1), 10487836 (1)
    colon adenocarcinoma 21.7 2 15937692 (1), 17942908 (1)
    carcinoma squamous cell 20.9 16 16691536 (2), 15033192 (2), 17334396 (2), 17614852 (1) (see all 9)
    adenocarcinoma 20.5 11 16231374 (3), 16691536 (2), 11027430 (1), 17614852 (1) (see all 7)

    Tumor Gene Database (TGDB): CTNND1

    Export disorders for CTNND1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTNND1 gene, integrated from 10 sources (see all 448):
    (articles sorted by number of sources associating them with CTNND1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells. (PubMed id 14699141)1, 2, 9 Kondapalli J.... Albuquerque M.L.C. (J. Biol. Chem. 2004)
    2. The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. (PubMed id 17344476)1, 2, 9 Hosking C.R.... Fujita Y. (Mol. Biol. Cell 2007)
    3. Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. (PubMed id 20371349)1, 2, 9 Ishiyama N....Ikura M. (Cell 2010)
    4. The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns). (PubMed id 8808291)1, 3, 9 Reynolds A.B....Daniel J.M. (Genomics 1996)
    5. Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. (PubMed id 9653641)1, 2, 9 Keirsebilck A.... van Roy F. (Genomics 1998)
    6. E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion. (PubMed id 17047063)1, 2, 9 Strumane K....van Roy F. (Cancer Res. 2006)
    7. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. (PubMed id 10207085)1, 2, 9 Daniel J.M. and Reynolds A.B. (Mol. Cell. Biol. 1999)
    8. p120-catenin is a binding partner and substrate for Group B Pak kinases. (PubMed id 20564219)1, 2 Wong L.E.... Minden A. (J. Cell. Biochem. 2010)
    9. The armadillo protein p0071 regulates Rho signalling during cytokinesis. (PubMed id 17115030)1, 2 Wolf A.... Hatzfeld M. (Nat. Cell Biol. 2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1500 HGNC: 2515 AceView: CTNND1andTMX2andC11orf31 Ensembl:ENSG00000198561 euGenes: HUgn1500
    ECgene: CTNND1 Kegg: 1500 H-InvDB: CTNND1

    (According to HUGE)
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    HUGE: KIAA0384

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CTNND1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTNND1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ctnnd1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTNND1 gene:
    Search GeneIP for patents involving CTNND1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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