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CTNND1 Gene

protein-coding GIFtS: 66

GC11P057287

catenin (cadherin-associated protein), delta 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CTNND)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CAS ^², ³
CTNND ^², ⁵
KIAA0384 ^¹, ², ³
P120CAS ^²
P120CTN ^²
p120 ^¹, ²
p120(cas) ^³
p120(ctn) ^³
p120cas ^¹
p120ctn ^¹

Descriptions
Cadherin-associated Src substrate ^³
catenin (cadherin-associated protein), delta 1 ^²
catenin, delta 1 ^²
p120 catenin ^³

External Ids
HGNC: 2515¹
Entrez Gene: 1500²
UniProtKB: O60716³
Ensembl: ENSG00000198561⁷

Search outside databases for aliases for CTNND1 gene

Previous GC identifers: GC11P059875 GC11P059042 GC11P057780 GC11P057304 GC11P057237 GC11P057286 GC11P057240

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CTNND1:

This gene encodes a member of the Armadillo protein family, which function in adhesion between

cells and signal transduction. Multiple translation initiation codons and althernative splicing

result in many different isoforms being translated. Not all of the full-length natures of the

described transcript variants have been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716

Function: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation

of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the

cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC

and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.

Promotes GLIS2 C-terminal cleavage

Gene Wiki entry for CTNND1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CTNND1 gene

Entrez Gene cytogenetic band: 11q11 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12.1

CTNND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P057287: (about GC identifiers)

Start:	57,285,810 bp from pter
End:	57,353,279 bp from pter
Size:	67,470 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033903.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716 (See protein sequence)

Recommended Name: Catenin delta-1

Size: 968 amino acids; 108170 Da

Subunit: Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin,

alpha-catenin, beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and

mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2

Subcellular location: Cytoplasm. Nucleus. Cell membrane (By similarity). Note=Interaction with

GLIS2 promotes nuclear translocation (By similarity)

Secondary accessions: A8K939 O15088 O60713 O60714 O60715 O60935 Q6DHZ7 Q6RBX8 Q9UP71 Q9UP72 Q9UP73

Alternative splicing: 32 isoforms: O60716-1 O60716-2 O60716-3 O60716-4 O60716-5 O60716-6 O60716-7 O60716-8

O60716-9 O60716-10 O60716-11 O60716-12 O60716-13 O60716-14 O60716-15 O60716-16

O60716-17 O60716-18 O60716-19 O60716-20 O60716-21 O60716-22 O60716-23 O60716-24

O60716-25 O60716-26 O60716-27 O60716-28 O60716-29 O60716-30 O60716-31 O60716-32

(Experimental confirmation may be lacking for some isoforms)

Post-translational modifications:

Phosphorylated (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (13 alternative transcripts):

NP_001078927.1 NP_001078928.1 NP_001078929.1 NP_001078930.1 NP_001078931.1 NP_001078932.1 NP_001078933.1 NP_001078934.1

NP_001078935.1 NP_001078936.1 NP_001078937.1 NP_001078938.1 NP_001322.1

ENSEMBL proteins:

ENSP00000354823 ENSP00000354907 ENSP00000351527 ENSP00000381996 ENSP00000353902 ENSP00000382004

ENSP00000354785

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (delta 1 Catenin)
	Human Recombinant Proteins from Abnova (CTNND1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	--
GO:0005737	cytoplasm	NAS	--
GO:0005886	plasma membrane	IEA	--

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Antibodies for CTNND1:

	Invitrogen Antibodies for CTNND1
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for CTNND1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CTNND1 (Catenin delta-1)
	Antibodies from Abcam (delta 1 Catenin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CTNND1)
	Novus Biologicals Antibodies for CTNND1

Assays for CTNND1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O60716

ProtoNet protein and cluster: O60716

1 Blocks protein family: IPB000225 Armadillo repeat

UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716

Domain: A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are

deleted

Similarity: Belongs to the beta-catenin family

Similarity: Contains 10 ARM repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CTNND1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 14): NM_001085458

Applied Biosystems Silencer® siRNAs for CTNND1

Sigma-Aldrich siRNA for CTNND1

Sigma-Aldrich shRNA Panels and shRNA for CTNND1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 13): NM_001085458
Myc/DDK tagged cDNA clones in CMV expression vector (see all 13): NM_001085458
untagged cDNA clones in CMV expression vector (see all 14): BC010501

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001085458

UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716

Function: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation

of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the

cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC

and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.

Promotes GLIS2 C-terminal cleavage

Induction: Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar

shear stress, which enhances wound closure

Genatlas biochemistry entry for CTNND1:

catenin delta 1,120kDa,multiple isoforms,desmosomal plaque component regulating cell adhesion

(component of E cadherin multiprotein complex, homologous to Drosophila Armadillo segment polarity

gene)

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ctnnd1):

cellular	digestive/alimentary	endocrine/exocrine gland	lethality-postnatal	nervous system
skin/coat/nails	tumorigenesis	vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IEA	--
GO:0045296	cadherin binding	IPI	12734196

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for CTNND1 (Your Favorite Gene powered by Ingenuity)

Germ Cell-Sertoli Cell Junction Signaling
Molecular Mechanisms of Cancer
Leukocyte Extravasation Signaling

GeneDecks CTNND1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CTNND1

5/70 Interacting proteins for CTNND1 (ENSP00000354823³) via UniProtKB, MINT, and/or STRING (see all 70 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDH1	ENSP00000268794³	STRING (score=.999)
SRC	ENSP00000362659³	STRING (score=.997)
ZBTB33	ENSP00000314153³	STRING (score=.996)
FYN	ENSP00000357656³	STRING (score=.995)
EGFR	ENSP00000275493³	STRING (score=.994)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0016055	Wnt receptor signaling pathway	IEA	--
GO:0016337	cell-cell adhesion	NAS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CTNND1
7 Novoseek chemical compound relationships for CTNND1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	67.20	119	1851549 (7), 11171320 (5), 7876318 (3), 10753936 (3) (see all 60)
phosphotyrosine	40.88	6	14699166 (1), 9378757 (1), 9742093 (1), 11433418 (1)
threonine	32.71	20	17719574 (5), 16935280 (4), 10024525 (2), 15684660 (2) (see all 9)
phenylalanine	8.00	5	11171320 (1), 15800180 (1), 11382764 (1)
lipid	2.67	1	10708762 (1)
calcium	0.00	20	18578707 (8), 19162191 (2), 14528017 (1), 17719574 (1) (see all 5)
zinc	0.00	1	10669742 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CTNND1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 14): NM_001085458

Sigma-Aldrich siRNA for CTNND1

Sigma-Aldrich shRNA Panels and shRNA for CTNND1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001085458 NM_001085459 NM_001085460 NM_001085461 NM_001085462 NM_001085463 NM_001085464 NM_001085465

NM_001085466 NM_001085467 NM_001085468 NM_001085469 NM_001331

REFSEQ mRNAs for CTNND1 gene (13 alternative transcripts):

NM_001085458.1 NM_001085459.1 NM_001085460.1 NM_001085461.1 NM_001085462.1 NM_001085463.1 NM_001085464.1 NM_001085465.1

NM_001085466.1 NM_001085467.1 NM_001085468.1 NM_001085469.1 NM_001331.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001085458 NM_001085459 NM_001085460 NM_001085461 NM_001085462 NM_001085463 NM_001085464 NM_001085465

NM_001085466 NM_001085467 NM_001085468 NM_001085469 NM_001331

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 13): NM_001085458
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 13): NM_001085458
                                 untagged cDNA clones in CMV expression vector (see all 14): BC010501

Additional cDNA sequence:

AF062317.1 AF062318.1 AF062319.1 AF062320.1 AF062321.1 AF062322.1 AF062323.1 AF062324.1

AF062325.1 AF062326.1 AF062327.1 AF062328.1 AF062329.1 AF062330.1 AF062331.1 AF062332.1

AF062333.1 AF062334.1 AF062335.1 AF062336.1 AF062337.1 AF062338.1 AF062339.1 AF062340.1

AF062341.1 AF062342.1 AF062343.1 AF062344.1 AK292554.1 BC010501.1 BC057224.1 BC075795.1

BT007333.1 CR614298.1 CR749275.1 Z36799.1

24/64 DOTS entries (see all 64 ):

DT.120747381 DT.95374970 DT.95188844 DT.95374961 DT.75158674 DT.95148870 DT.100891143 DT.97864468

DT.92005448 DT.97782379 DT.120747228 DT.97807476 DT.100891158 DT.120747252 DT.97797665 DT.95374968

DT.100891153 DT.75146926 DT.92455619 DT.100891166 DT.120747242 DT.100891154 DT.92455647 DT.100709750

24/274 AceView cDNA sequences (see all 274 ):

BG742934 CB109101 BM770297 AW964535 BI771847 BE142538 BU158964 BE278811

BI223383 BI518324 N67495 BM710534 BG740965 AA317874 BE466125 CR625628

CD654713 AA299026 AA335916 BQ957743 BQ690091 AI422656 CR604249 AA367361

highest scoring ESTs for CTNND1:

AF062341 AA024656 AA130319 AA291768 AA292946 AA299390 AA302160 AA337345 AA345139 AA406578

Unigene Cluster for CTNND1:

Catenin (cadherin-associated protein), delta 1

Hs.166011 [show with all ESTs]

Unigene Representative Sequence: NM_001085458

GeneLoc Exon Structure

5/27 Alternative Splicing Database (ASD) splice patterns (SP) for CTNND1 (see all 27 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	·	11c	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17	^
SP1:																																					-								-
SP2:																									-		-										-								-
SP3:																									-		-				-						-								-
SP4:																									-		-		-		-						-								-
SP5:																																					-								-

ExUns:	18	^	19	^	20	^	21	^	22	^	23a	·	23b	^	24	^	25a	·	25b	^	26a	·	26b	^	27a	·	27b	^	28a	·	28b
SP1:																	-										-
SP2:																	-								-		-
SP3:																	-								-		-
SP4:																	-										-
SP5:																	-								-		-

About this scheme

ECgene alternative splicing isoforms for CTNND1

7 Ensembl transcripts including schematic representations:

ENST00000361332 ENST00000361796 ENST00000358694 ENST00000399039 ENST00000360682 ENST00000399050

ENST00000361391

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CTNND1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CTNND1

¹ / ² / ³

11 probe-sets matching CTNND1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40444_s_at²^{, 3}	U95-A	1	1.00	1.00	0.76	1.46	AB002382	0.80	0.67	0.74	1
61840_s_at²^{, 3}	U95-C	2	1.00	0.97	0.46	1.29	AI863000	0.20	1.00	0.72	1
40443_at²^{, 3}	U95-A	1	0.31	1.00	0.67	0.83	AF062341	0.80	1.00	0.91	1
61841_r_at*²^{, 3}	U95-C	1	1.00	1.00	0.78	0.47	AI863000	0.20	1.00	0.72	1
211240_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB002382	0.80	0.67	0.74	1
208862_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW073672	0.40	1.00	0.76	1
208407_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001331	0.60	0.78	0.69	1
211240_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208862_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208407_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1557944_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAACTGGAGT

SOURCE GeneReport for Unigene cluster: Hs.166011
Expression variation in blood from EXPOLDB for CTNND1
UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716
Tissue specificity: Expressed in vascular endothelium

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CTNND1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CTNND1¹	--	catenin (cadherin-associated protein), delta 1	93.83(n) 98.04(a)	483489 XM_844539.1 XP_849632.1
chimpanzee (Pan troglodytes)	CTNND1¹	--	catenin (cadherin-associated protein), delta 1	99.72(n) 99.79(a)	743685 XM_001140660.1 XP_001140660.1
cow (Bos taurus)	CTNND1¹	--	catenin (cadherin-associated protein), delta 1	88.16(n) 95.86(a)	515187 XM_593164.3 XP_593164.3
rat (Rattus norvegicus)	Ctnnd1¹	--	catenin (cadherin associated protein), delta 1	91.19(n) 98.07(a)	311163 XM_242062.4 XP_242062.4
mouse (Mus musculus)	Ctnnd1^{1, 5}	2 (47.80 cM)⁵	catenin (cadherin associated protein), delta 1^{1, 5}	90.81(n)¹ 97.76(a)¹	12388¹ NM_007615.3¹ NP_031641.2¹ AA409437⁵ AB093237⁵ (see all 27)

About this table Species with no ortholog for CTNND1

ENSEMBL Gene Tree for CTNND1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CTNND1 gene

CTNND2² PKP4² ARVCF²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/328 NCBI SNPs in CTNND1 are shown (see all 328 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 109)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs529838^1,2	A,C,F,H	57285604(+)	`CCTCTC/TCCGCC`	13	--	ng5¹		14	NS NA EU EA WA	1308
	rs11229142^1,2	A,C,F,H	57343684(+)	`ATCCTC/TTATAG`	13	--	ng3¹		7	NA EU EA WA	562
	rs558653^1,2	A,C,F,H	57285706(+)	`TCCCCC/TTGTCT`	13	--	ng5¹		2	NS EU	290
	rs708228^1,2	A,C,F,H	57342238(+)	`TTTTCC/TTGGTG`	13	--	ut3¹ ese³ trp³		12	NS MN EU EA WA	1426
	rs11570176^1,2	C,F,H	57286005(+)	`AATCAA/GCTGCC`	13	--	ut5¹		5	NS EU EA WA	556
	rs11570222^1,2	C,F,H	57339484(+)	`CAATAG/AAACAC`	13	K/R	mis¹ ese³		18	NS EU EA WA NA	1802
	rs11570199^1,2	C,F,H	57326214(+)	`AGGCTC/TGTGAT`	13	R/C	mis¹ ese³		9	NS EU EA WA	1016
	rs11229141^1,2	C,H	57340570(+)	`ATTCCC/TTCCAT`	13	--	ut3¹		4	EU EA WA	418
	rs11229133^1,2	C,H	57320596(+)	`AGTTTC/TTAACA`	13	S/F	mis¹ ese³		4	EU EA WA	418
	rs11570228^1,2	F,H	57340748(+)	`TGTATA/GTGCAA`	13	--	ut3¹ ese³		5	NS EU EA WA	576

About this table

HapMap Linkage Disequilibrium images for CTNND1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601045

UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716

May contribute to cell malignancy. Complete loss of expression was observed in

approximately 10% of invasive ductal breast carcinomas investigated

10/40 Novoseek disease relationships for CTNND1 gene (see all 40 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma lobular	52.24	2	17143261 (1), 17325485 (1)
tumors	34.45	79	17325485 (6), 16231374 (5), 18595142 (4), 17030444 (3) (see all 33)
metastasis	30.03	20	10397474 (3), 18595142 (2), 16231374 (2), 19154401 (2) (see all 11)
carcinoma	27.98	14	7542384 (2), 7876318 (1), 8653709 (1), 10393933 (1) (see all 9)
cancer	27.49	26	17942908 (2), 11755823 (2), 15489912 (2), 10725216 (2) (see all 16)
prostate carcinoma	26.94	10	14748788 (4), 7542384 (2), 10687853 (1), 10487836 (1)
colon adenocarcinoma	23.92	2	15937692 (1), 17942908 (1)
adenocarcinoma	23.26	11	16231374 (3), 16691536 (2), 11027430 (1), 17614852 (1) (see all 7)
colonic polyps	21.14	1	9176391 (1)
carcinoma squamous cell	21.03	15	16691536 (2), 15033192 (2), 17334396 (2), 17614852 (1) (see all 8)

About this table

Tumor Gene Database: CTNND1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/330 PubMed articles for CTNND1 gene (see all 330 ):

Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells. (PubMed id 14699141)^{1, 3, 4} Kondapalli J.... Albuquerque M.L.C. (2004)
The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. (PubMed id 17344476)^{1, 3, 4} Hosking C.R.... Fujita Y. (2007)
The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns). (PubMed id 8808291)^{1, 2, 3} Reynolds A.B....Daniel J.M. (1996)
Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. (PubMed id 9653641)^{1, 3, 4} Keirsebilck A.... van Roy F. (1998)
The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. (PubMed id 10207085)^{1, 3, 4} Daniel J.M. and Reynolds A.B. (1999)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Global phosphoproteome of HT-29 human colon adenocarcinoma cells. (PubMed id 16083285)^{3, 4} Kim J.-E.... White F.M. (2005)
Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC). (PubMed id 16212419)^{3, 4} Amanchy R.... Pandey A. (2005)
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)^{3, 4} Zhang Y.... White F.M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1500	HGNC: 2515	AceView: CTNND1andTMX2andC11orf31	Ensembl:ENSG00000198561	euGenes: HUgn1500
ECgene: CTNND1	H-InvDB: CTNND1

(According to HUGE)
About This Section

HUGE: KIAA0384

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CTNND1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ctnnd1/

Licensable Technologies for CTNND1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CTNND1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CTNND1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Antibodies & Assays for CTNND1 (Catenin delta-1)

	Recombinant Proteins (delta 1 Catenin)
	Antibodies (delta 1 Catenin)

Search OriGene for CTNND1

Search Tocris compounds for CTNND1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CTNND1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CTNND1 Gene at Home site.
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CTNND1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for CTNND1

Summaries
for CTNND1

Genomic Location
for CTNND1

Proteins
for CTNND1

Protein Domains/
Families
for CTNND1

Gene Function
for CTNND1

Pathways & Interactions
for CTNND1

Drugs & Compounds
for CTNND1

Transcripts
for CTNND1

Expression
for CTNND1

Orthologs
for CTNND1

Paralogs
for CTNND1

SNPs/Variants
for CTNND1

Disorders & Mutations
for CTNND1

Medical News
for CTNND1

Publications
for CTNND1

Search for CTNND1

Genome Databases showing CTNND1

Other Databases showing CTNND1

Specialized Databases showing CTNND1

Licensable Technologies
for CTNND1

Services
for CTNND1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CTNND1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor CTNND1

Summariesfor CTNND1

Genomic Locationfor CTNND1

Proteinsfor CTNND1

Protein Domains/Familiesfor CTNND1

Gene Functionfor CTNND1

Pathways & Interactionsfor CTNND1

Drugs & Compoundsfor CTNND1

Transcriptsfor CTNND1

Expression for CTNND1

Orthologsfor CTNND1

Paralogsfor CTNND1

SNPs/Variantsfor CTNND1

Disorders & Mutationsfor CTNND1

Medical Newsfor CTNND1

Publicationsfor CTNND1

Search for CTNND1

Genome Databases showing CTNND1

Other Databases showing CTNND1

Specialized Databases showing CTNND1

Licensable Technologiesfor CTNND1

Servicesfor CTNND1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CTNND1

Summaries
for CTNND1

Genomic Location
for CTNND1

Proteins
for CTNND1

Protein Domains/
Families
for CTNND1

Gene Function
for CTNND1

Pathways & Interactions
for CTNND1

Drugs & Compounds
for CTNND1

Transcripts
for CTNND1

Expression
for CTNND1

Orthologs
for CTNND1

Paralogs
for CTNND1

SNPs/Variants
for CTNND1

Disorders & Mutations
for CTNND1

Medical News
for CTNND1

Publications
for CTNND1

Licensable Technologies
for CTNND1

Services
for CTNND1