CTNND1 Gene
protein-coding GIFtS: 67
GCID: GC11P057531
|
|
catenin (cadherin-associated protein), delta 1
(Previous symbol: CTNND)
| |
Aliases
for CTNND1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Catenin (Cadherin-Associated Protein), Delta 11 2 | | P120ctn1 | | CTNND1 2 5 | | P120CAS2 | | P1201 | | P120CTN2 | | KIAA03841 3 | | Catenin Delta-12 | | Cadherin-Associated Src Substrate2 3 | | P120(CAS)1 | | CAS2 3 | | P120(CTN)1 | | P120 Catenin2 3 | | P120(Cas)1 | | P120cas1 | | P120(Ctn)1 |
Export aliases for CTNND1 gene to outside databasesPrevious GC identifers: GC11P059875 GC11P059042 GC11P057780 GC11P057304 GC11P057237 GC11P057286 GC11P057240 GC11P057287 GC11P053877 |
Summaries
for CTNND1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CTNND1:
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signaltransduction. Multiple translation initiation codons and alternative splicing result in many different isoforms beingtranslated. Not all of the full-length natures of the described transcript variants have been determined. Read-throughtranscription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2(TMX2) gene. (provided by RefSeq, Dec 2010)
UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716Function: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes ofthe Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- andE-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF,PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage
Gene Wiki entry for CTNND1
|
Genomic Views
for CTNND1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CTNND1 gene promoter:
STAT5B Pax-5 POU6F1 (c2) STAT5A Nkx2-5 LCR-F1 Evi-1 Gfi-1 CREB deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for CTNND1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTNND1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q11 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12.1CTNND1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P057531: view genomic region
(about GC identifiers)
Start:
|
57,520,715 bp from pter |
End:
|
57,587,018 bp from pter |
Size:
|
66,304 bases |
Orientation:
|
plus strand |
|
Proteins
for CTNND1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716 (See
protein sequence)Recommended Name: Catenin delta-1 Size: 968 amino acids; 108170 Da
Subunit: Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin,beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin.Interacts with ZBTB33. Interacts with GLIS2. Interacts with NANOS1 (via N-terminal region). Interacts with FER
Subcellular location: Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (Bysimilarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to thecytoplasm
Sequence caution: Sequence=BAA20838.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from  and Proteopedia  for CTNND1:3L6X (3D)
3L6Y (3D)
Secondary accessions: A8K939 O15088 O60713 O60714 O60715 O60935 Q6DHZ7 Q6RBX8 Q9UP71 Q9UP72 Q9UP73Alternative splicing: 32 isoforms: O60716-1 O60716-2 O60716-3 O60716-4 O60716-5 O60716-6 O60716-7 O60716-8 O60716-9 O60716-10 O60716-11 O60716-12 O60716-13 O60716-14 O60716-15 O60716-16 O60716-17 O60716-18 O60716-19 O60716-20 O60716-21 O60716-22 O60716-23 O60716-24 O60716-25 O60716-26 O60716-27 O60716-28 O60716-29 O60716-30 O60716-31 O60716-32 (Contains a phosphothreonine at position 566)Explore the universe of human proteins at neXtProt for CTNND1: NX_O60716
Post-translational modifications:
Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated byPTPRJ1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60716
CTNND1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (22 alternative transcripts):
NP_001078927.1 NP_001078928.1 NP_001078929.1 NP_001078930.1 NP_001078931.1 NP_001078932.1 NP_001078933.1 NP_001078934.1 NP_001078935.1 NP_001078936.1 NP_001078937.1 NP_001078938.1 NP_001193812.1 NP_001193813.1 NP_001193814.1 NP_001193815.1 NP_001193816.1 NP_001193817.1 NP_001193818.1 NP_001193819.1 NP_001193820.1 NP_001322.1
ENSEMBL proteins: ENSP00000436543 ENSP00000434808 ENSP00000435242 ENSP00000436323 ENSP00000409930 ENSP00000382004 ENSP00000354785 ENSP00000354823 ENSP00000432075 ENSP00000437156 ENSP00000351527 ENSP00000434949 ENSP00000437051 ENSP00000435379 ENSP00000432243 ENSP00000436744 ENSP00000413586 ENSP00000434900 ENSP00000435266 ENSP00000432623 ENSP00000433158 ENSP00000435494 ENSP00000434672 ENSP00000433276 ENSP00000433334 ENSP00000437327 ENSP00000403518 ENSP00000434017 ENSP00000435789 ENSP00000432041 ENSP00000432299 ENSP00000431600 ENSP00000434202 ENSP00000431208 ENSP00000381996 ENSP00000353902 ENSP00000354907 Reactome Protein details: O60716
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
CTNND1 for ontologies About GeneDecksing
CTNND1 Antibody Products:
Assay Products for CTNND1: |
Protein
Domains /
Families
for CTNND1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CTNND1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60716ProtoNet protein and cluster: O60716 1 Blocks protein family: IPB000225 Armadillo repeat
UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716Domain: A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deletedSimilarity: Belongs to the beta-catenin familySimilarity: Contains 10 ARM repeats |
Function
for CTNND1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716Function: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes ofthe Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- andE-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF,PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavageInduction: Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, whichenhances wound closure Genatlas biochemistry entry for CTNND1:catenin delta 1,120kDa,multiple isoforms,desmosomal plaque component regulating cell adhesion (component of E cadherinmultiprotein complex, homologous to Drosophila Armadillo segment polarity gene)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTNND1 (see all 19)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTNND1 (see all 14)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 13): CTNND1 (NM_001085469) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTNND1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTNND1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNND1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
CTNND1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CTNND1:
Animal Models:
9 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ctnnd1):
CTNND1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CTNND1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell-cell junction organization | | | 2 | Cell adhesion Endothelial cell contacts by junctional mechanisms | | | 3 | Sertoli-Sertoli Cell Junction Dynamics | | | 4 | Cytoskeleton remodeling Slit-Robo signaling | | | 5 | Cell adhesion_Integrin-mediated cell adhesion and migration | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for CTNND1
5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CTNND1 (see all 6)
3 
Cell Signaling Technology (CST) Pathways for CTNND1
3  GeneGo (Thomson Reuters) Pathways for CTNND1
5/8  BioSystems Pathways for CTNND1 (see all 8)
4 
Reactome Pathways for CTNND1
2 
Kegg Pathways (Kegg details for CTNND1):
CTNND1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTNND1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/643 Interacting proteins for CTNND1 (O607161, 2, 3 ENSP000003820044) via UniProtKB, MINT, STRING, and/or I2D (see all 643)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
CTNND1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CTNND1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CTNND1 for compounds About GeneDecksing
 Browse Tocris compounds for CTNND1
10/17 Novoseek chemical compound relationships for CTNND1 gene (see all 17) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
66.9 |
128 |
1851549 (7), 11171320 (5), 7876318 (3), 10753936 (3) (see all 62) |
| phosphotyrosine |
42.9 |
6 |
14699166 (1), 9378757 (1), 9742093 (1), 11433418 (1) |
| threonine |
30.5 |
20 |
17719574 (5), 16935280 (4), 10024525 (2), 15684660 (2) (see all 9) |
| nocodazole |
24.2 |
3 |
17584295 (2), 14676216 (1) |
| serine |
19.4 |
17 |
17719574 (5), 10024525 (2), 10657259 (2), 10409703 (1) (see all 10) |
| vegf |
8.28 |
6 |
10657259 (3), 19755858 (1), 12771128 (1), 9625748 (1) |
| phenylalanine |
5.66 |
5 |
11171320 (1), 15800180 (1), 11382764 (1) |
| oxygen |
4.24 |
2 |
19422420 (1) |
| lipid |
0 |
2 |
10708762 (1), 19615358 (1) |
| calcium |
0 |
20 |
18578707 (8), 19162191 (2), 14528017 (1), 17719574 (1) (see all 5) |
Search CenterWatch for drugs/clinical trials and news about CTNND1 / CTND1
|
Transcripts
for CTNND1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CTNND1 gene (22 alternative transcripts): NM_001085458.1 NM_001085459.1 NM_001085460.1 NM_001085461.1 NM_001085462.1 NM_001085463.1 NM_001085464.1 NM_001085465.1 NM_001085466.1 NM_001085467.1 NM_001085468.1 NM_001085469.1 NM_001206883.1 NM_001206884.1 NM_001206885.1 NM_001206886.1 NM_001206887.1 NM_001206888.1 NM_001206889.1 NM_001206890.1 NM_001206891.1 NM_001331.2 Unigene Cluster for CTNND1: Catenin (cadherin-associated protein), delta 1 Hs.166011 [show with all ESTs]Unigene Representative Sequence: NM_00108545818/40 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 40): ENST00000524630(uc021qjk.1) ENST00000529919 ENST00000533189 ENST00000529526
ENST00000426142 ENST00000399050(uc001nlf.2 uc001nmc.4) ENST00000361391
ENST00000361332(uc001nme.4) ENST00000532463 ENST00000529986 ENST00000358694
ENST00000532787 ENST00000533667 ENST00000532649 ENST00000528621 ENST00000530748
ENST00000428599 ENST00000527467(uc001nlx.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTNND1 (see all 19)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTNND1 (see all 14)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 13): CTNND1 (NM_001085469) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTNND1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTNND1 |
Additional cDNA sequence: AF062317.1 AF062318.1 AF062319.1 AF062320.1 AF062321.1 AF062322.1 AF062323.1 AF062324.1 AF062325.1 AF062326.1 AF062327.1 AF062328.1 AF062329.1 AF062330.1 AF062331.1 AF062332.1 AF062333.1 AF062334.1 AF062335.1 AF062336.1 AF062337.1 AF062338.1 AF062339.1 AF062340.1 AF062341.1 AF062342.1 AF062343.1 AF062344.1 AK292554.1 BC010501.1 BC057224.1 BC075795.1 BT007333.1 CR749275.1 NR_037646.1 Z36799.1 24/60 DOTS entries (see all 60): DT.120747381 DT.95374970 DT.95188844 DT.95374961 DT.95148870 DT.75158674 DT.100891143 DT.92005448 DT.97864468 DT.120747228 DT.97782379 DT.97807476 DT.120747252 DT.100891158 DT.97797665 DT.95374968 DT.100891153 DT.75146926 DT.92455619 DT.120747242 DT.100891154 DT.100891166 DT.92455647 DT.92455626 24/274 AceView cDNA sequences (see all 274): BU623934 AA622185 BQ181178 BQ695307 CD653508 CR595701 CR614298 BQ949244 BX419011 BQ014401 BQ937601 BM767335 AL603254 AI814868 AI283681 CR601411 AL712106 CB105393 BU931698 BQ687916 AA299026 BP379418 BG675692 AA335916
GeneLoc Exon Structure
5/27 Alternative Splicing Database (ASD) splice patterns (SP) for CTNND1 (see all 27) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | - | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | |
| ExUns: | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 | ^ | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27a | · | 27b | ^ | 28a | · | 28b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | |
ECgene alternative splicing isoforms for CTNND1
|
Expression
for CTNND1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CTNND1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAACTGGAGT
About this image
See CTNND1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTNND1
SOURCE GeneReport for Unigene cluster: Hs.166011
UniProtKB/Swiss-Prot: CTND1_HUMAN, O60716Tissue specificity: Expressed in vascular endothelium
SABiosciences Expression via Pathway-Focused PCR Arrays including CTNND1: | Extracellular Matrix & Adhesion Molecules in human mouse rat | | Adherens Junctions in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTNND1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTNND1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTNND1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTNND1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNND1 |
Orthologs
for CTNND1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CTNND1 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CTNND11 |
catenin (cadherin-associated protein), delta 1 |
77.98(n)
86.34(a) |
|
428852 XM_001232050.2 XP_001232051.2 |
lizard
(Anolis carolinensis) |
Reptilia |
CTNND16 |
-- |
86(a) |
1 ↔ 1 |
1(91376439-91409474) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1003347141 |
catenin delta-1-like |
62.03(n)
63.92(a) |
|
100334714 XM_002660535.2 XP_002660581.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
p120ctn3 |
-- |
43(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
jac-13 |
-- |
32(a) |
|
IV(15998290-16017650) -- |
ENSEMBL Gene Tree for CTNND1 (if available)
TreeFam Gene Tree for CTNND1 (if available) |
Paralogs
for CTNND1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CTNND1 gene
- PKP22 PKP12 PKP32 CTNND22 ARVCF2 PKP42
6 SIMAP similar genes for CTNND1 using alignment to 7 protein entries: CTND1_HUMAN (see all proteins):DKFZp781O2021 ps1ly2h-25 ARVCF PKP4 CTNND2 PKP1
CTNND1 for paralogs About GeneDecksing
|
Genomic Variants
for CTNND1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CTNND1 (57520715 - 57587018 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CTNND1: --
Human Gene Mutation Database (HGMD): CTNND1
| SABiosciences Cancer Mutation PCR Assays |
| 2 SABiosciences qBiomarker Copy Number PCR Arrays containing CTNND1: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTNND1 |
|
Disorders
/ Diseases
for CTNND1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CTNND1 for disorders About GeneDecksing
OMIM gene information: 601045
OMIM disorders: --
20/54  diseases for CTNND1 (see all 54): About MalaCardsfamilial adenomatous polyposis sclerosing hemangioma adenomatous polyposis coli sarcomatoid renal cell carcinoma
pulmonary sclerosing hemangioma non-hodgkin lymphoma lobular neoplasia crescentic glomerulonephritis
colonic polyps cutaneous malignant melanoma hemangioma esophageal squamous cell carcinoma
renal cell carcinoma squamous cell carcinoma carcinoma hodgkin's lymphoma
polyposis glomerulonephritis endometrial carcinoma inflammatory breast cancer
2 diseases from the University of Copenhagen DISEASES database for CTNND1:Invasive lobular carcinoma Lobular neoplasia 10/40 Novoseek disease relationships for CTNND1 gene (see all 40) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| carcinoma lobular |
56.8 |
5 |
20078969 (2), 17143261 (1), 20510078 (1), 17325485 (1) |
| tumors |
35.5 |
83 |
17325485 (6), 16231374 (5), 18595142 (4), 17030444 (3) (see all 36) |
| metastasis |
32.2 |
26 |
19615783 (4), 10397474 (3), 18595142 (2), 16231374 (2) (see all 13) |
| carcinoma |
28.3 |
15 |
7542384 (2), 7876318 (1), 8653709 (1), 19551809 (1) (see all 10) |
| cancer |
28.3 |
28 |
17942908 (2), 11755823 (2), 15489912 (2), 10725216 (2) (see all 17) |
| carcinoma ductal |
27.3 |
6 |
20078969 (2), 9422525 (1), 20510078 (1), 17721269 (1) |
| prostate carcinoma |
24.9 |
10 |
14748788 (4), 7542384 (2), 10687853 (1), 10487836 (1) |
| colon adenocarcinoma |
21.7 |
2 |
15937692 (1), 17942908 (1) |
| carcinoma squamous cell |
20.9 |
16 |
16691536 (2), 15033192 (2), 17334396 (2), 17614852 (1) (see all 9) |
| adenocarcinoma |
20.5 |
11 |
16231374 (3), 16691536 (2), 11027430 (1), 17614852 (1) (see all 7) |
Tumor Gene Database (TGDB): CTNND1
Export disorders for CTNND1 gene to outside databases
|
Publications
for CTNND1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CTNND1 gene, integrated from 9 sources (see all 428):
(articles sorted by number of sources associating them with CTNND1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Laminar shear stress differentially modulates gene expression of p120 catenin, Kaiso transcription factor, and vascular endothelial cadherin in human coronary artery endothelial cells. (PubMed id 14699141)1, 2, 9 Kondapalli J.... Albuquerque M.L.C. (2004)
- The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. (PubMed id 17344476)1, 2, 9 Hosking C.R.... Fujita Y. (2007)
- The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns). (PubMed id 8808291)1, 3, 9 Reynolds A.B....Daniel J.M. (1996)
- Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. (PubMed id 9653641)1, 2, 9 Keirsebilck A.... van Roy F. (1998)
- E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion. (PubMed id 17047063)1, 2, 9 Strumane K....van Roy F. (2006)
- The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. (PubMed id 10207085)1, 2, 9 Daniel J.M. and Reynolds A.B. (1999)
- p120-catenin is a binding partner and substrate for G roup B Pak kinases. (PubMed id 20564219)1, 2 Wong L.E....Minden A. (2010)
- The armadillo protein p0071 regulates Rho signalling during cytokinesis. (PubMed id 17115030)1, 2 Wolf A.... Hatzfeld M. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn). (PubMed id 12370829)1, 2 Holsinger L.J....Jallal B. (2002)
|
External Searches for CTNND1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CTNND1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CTNND1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing CTNND1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CTNND1 gene:
Search GeneIP for patents involving CTNND1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CTNND1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for CTNND1 | | OriGene shRNA RFP for CTNND1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTNND1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTNND1 | | | OriGene Protein Over-expression Lysate for CTNND1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CTNND1 | | OriGene 3'-UTR Clone for CTNND1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTNND1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTNND1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CTNND1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CTNND1 | | OriGene Custom Protein Services for CTNND1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTNND1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTNND1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTNND1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTNND1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTNND1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTNND1 |
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| | Antibodies & Assays for CTNND1 |
| | | | Search Tocris compounds for CTNND1 |
| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNND1 |
|  |  |  | | | | ThermoFisher Antibodies for CTNND1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTNND1 |
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