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CTNNBL1 Gene

protein-coding   GIFtS: 59
GCID: GC20P036322

Catenin, Beta Like 1

(Previous name: chromosome 20 open reading frame 33)
(Previous symbol: C20orf33)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Catenin, Beta Like 11 2     P14L2
C20orf331 2 3     PP83042
NAP2 3 5     Beta-Catenin-Like Protein 12
Nuclear Associated Protein1 2     dJ633O20.12
Testis Development Protein NYD-SP192 3     Nuclear-Associated Protein3
Chromosome 20 Open Reading Frame 331     

External Ids:    HGNC: 158791   Entrez Gene: 562592   Ensembl: ENSG000001327927   OMIM: 6115375   UniProtKB: Q8WYA63   

Export aliases for CTNNBL1 gene to outside databases

Previous GC identifers: GC20P036050 GC20P036960 GC20P037007 GC20P035755 GC20P033058


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTNNBL1 Gene:
The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like
(PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The
encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced
deaminase and is important for antibody diversification. This gene may also be associated with the development of
obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined
on the X chromosome. (provided by RefSeq, Jul 2013)

GeneCards Summary for CTNNBL1 Gene:
CTNNBL1 (catenin, beta like 1) is a protein-coding gene. Diseases associated with CTNNBL1 include syringobulbia, and syringomyelia. GO annotations related to this gene include enzyme binding.

UniProtKB/Swiss-Prot: CTBL1_HUMAN, Q8WYA6
Function: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for
activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May
induce apoptosis

Gene Wiki entry for CTNNBL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTNNBL1 gene promoter:
         E2F-4   E2F-3a   Elk-1   E2F-5   Sp1   E2F-2   CBF-B   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CTNNBL1 promoter sequence
   Search Chromatin IP Primers for CTNNBL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTNNBL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23-q12   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23-q12

CTNNBL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTNNBL1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P036322:  view genomic region     (about GC identifiers)

Start:
36,322,408 bp from pter      End:
36,500,531 bp from pter
Size:
178,124 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTBL1_HUMAN, Q8WYA6 (See protein sequence)
Recommended Name: Beta-catenin-like protein 1  
Size: 563 amino acids; 65173 Da
Subunit: Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of
PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8.
Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for
the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its
N-terminal NLS) with KPNA1 and KPNA2
Sequence caution: Sequence=AAQ15267.1; Type=Frameshift; Positions=96; Sequence=BAB14992.1; Type=Erroneous
initiation;
5 PDB 3D structures from and Proteopedia for CTNNBL1:
4CB8 (3D)        4CB9 (3D)        4CBA (3D)        4HM9 (3D)        4HNM (3D)    
Secondary accessions: Q0VAL9 Q53HI8 Q5JWZ2 Q5JWZ3 Q5JWZ7 Q5JWZ8 Q8N454 Q8NCL2 Q8TBD6 Q96KD2
Q9H7A5 Q9NQF9 Q9NTX0 Q9Y3M7
Alternative splicing: 3 isoforms:  Q8WYA6-1   Q8WYA6-2   Q8WYA6-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for CTNNBL1: NX_Q8WYA6

Explore proteomics data for CTNNBL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys332, Lys429
  • Modification sites at PhosphoSitePlus

  • See CTNNBL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001268424.1  NP_110517.2  

    ENSEMBL proteins: 
     ENSP00000355050   ENSP00000394464   ENSP00000362572   ENSP00000362568   ENSP00000384355  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR013180 CTNNBL1_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q8WYA6

    ProtoNet protein and cluster: Q8WYA6


    CTNNBL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTBL1_HUMAN, Q8WYA6
    Function: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for
    activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May
    induce apoptosis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI18722174
    GO:0019899enzyme binding IPI18722174
         
    CTNNBL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CTNNBL1:
     Increased cell number in S 

    Animal Models:
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    miRTarBase miRNAs that target CTNNBL1:
    hsa-mir-25-3p (MIRT050320), hsa-mir-1229-3p (MIRT036306), hsa-mir-320a (MIRT044639), hsa-mir-155-5p (MIRT020731), hsa-mir-92a-3p (MIRT049224), hsa-mir-149-5p (MIRT045603)

    Block miRNA regulation of human, mouse, rat CTNNBL1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CTNNBL1:
    hsa-miR-1323 hsa-miR-548o
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNBL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTBL1_HUMAN, Q8WYA6: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000974Prp19 complex IDA15175653
    GO:0005634nucleus IDA--
    GO:0005681spliceosomal complex IDA--
    GO:0005730NOT nucleolus IDA--

    CTNNBL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTNNBL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for CTNNBL1):
        Spliceosome


    CTNNBL1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTNNBL1
    Interactions:

        Search GeneGlobe Interaction Network for CTNNBL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTNNBL1 (Q8WYA61, 2, 3 ENSP000003550504) via UniProtKB, MINT, STRING, and/or I2D (see all 58)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST4H4P628053, ENSP000003507674I2D: score=1 STRING: ENSP00000350767
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006915apoptotic process IEA--
    GO:0008380RNA splicing IEA--
    GO:0016445somatic diversification of immunoglobulins IMP18722174
    GO:0043065positive regulation of apoptotic process IDA12659813

    CTNNBL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTNNBL1 (CTBL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CTNNBL1 gene (2 alternative transcripts): 
    NM_001281495.1  NM_030877.4  

    Unigene Cluster for CTNNBL1:

    Catenin, beta like 1
    Hs.472667  [show with all ESTs]
    Unigene Representative Sequence: AK091216
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361383(uc021wdj.1) ENST00000447935 ENST00000373473(uc002xhh.3)
    ENST00000473857(uc002xhi.3) ENST00000373469(uc002xhj.3) ENST00000472237
    ENST00000481674 ENST00000405275(uc021wdi.1)
    miRNA
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    hsa-miR-1323 hsa-miR-548o
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    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTNNBL1
      QuantiTect SYBR Green Assays in human, mouse, rat CTNNBL1
      QuantiFast Probe-based Assays in human, mouse, rat CTNNBL1

    Additional mRNA sequence: 

    AF086002.1 AF239607.1 AF367471.1 AF370431.1 AK024761.1 AK074663.1 AK091216.1 AK130301.1 
    AK222592.1 AK293420.1 BC022802.1 BC036739.1 BC121005.1 BC121006.1 

    18 DOTS entries:

    DT.92448253  DT.92448248  DT.97860029  DT.40219215  DT.120806613  DT.100797576  DT.92448238  DT.95213835 
    DT.100797573  DT.120806590  DT.95160977  DT.120806593  DT.120806595  DT.120806598  DT.120806615  DT.91988424 
    DT.423700  DT.427585 

    Selected AceView cDNA sequences (see all 403):

    NM_030877 BQ064491 CB529536 BQ019266 BQ646897 AA350719 AA988339 BP341755 
    AA984038 BF196319 BU501130 BM806716 AW614103 BQ890307 BQ058687 BQ071139 
    AI867924 BG169270 AA760749 BF939702 CR606693 BM825173 H64423 CA425814 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CTNNBL1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:                                      -                       -                                                                     
    SP2:                    -     -     -                             -                             -                                       
    SP3:                                                                                            -                                       


    ECgene alternative splicing isoforms for CTNNBL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTNNBL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTCTCTCA
    CTNNBL1 Expression
    About this image


    CTNNBL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Crest (Gastrulation Derivatives)
             Neural crest-like cells
    CTNNBL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTNNBL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.472667

    UniProtKB/Swiss-Prot: CTBL1_HUMAN, Q8WYA6
    Tissue specificity: Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and
    thyroid

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNBL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CTNNBL1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctnnbl11 , 5 catenin, beta like 11, 5 88.99(n)1
    96.09(a)1
      2 (78.40 cM)5
    666421  NM_025680.41  NP_079956.31 
     1577374015 
    chicken
    (Gallus gallus)
    Aves CTNNBL11 catenin, beta like 1 82.47(n)
    92.9(a)
      419299  XM_001234107.3  XP_001234108.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTNNBL16
    catenin, beta like 1
    72(a)
    1 ↔ 1
    GL343413.1(596146-648962)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.137552 Xenopus laevis transcribed sequence with moderate similarity more 80.06(n)    BJ057933.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc776732 hypothetical protein MGC77673 74.71(n)   393840  BC063231.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119641 , 3 CG119641 54(a)3
    61.17(n)1
    59.06(a)1
      85B73
    410681  NM_141590.41  NP_649847.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M01E11.21 , 3 M01E11.21 46(a)3
    52.46(n)1
    48.95(a)1
      I(5579670-5581798)3
    1722141  NM_059233.31  NP_491634.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G027101 AT3G02710 52.43(n)
    43.78(a)
      821269  NM_111139.2  NP_186920.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g08313001 Os02g0831300 50.43(n)
    43.38(a)
      4331250  NM_001055153.1  NP_001048618.1 


    ENSEMBL Gene Tree for CTNNBL1 (if available)
    TreeFam Gene Tree for CTNNBL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTNNBL1 gene

    CTNNBL1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CTNNBL1
    PGOHUM00000241262


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTNNBL1 (see all 3618)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819177461,2
    --36320494(+) TCAATC/TTCCTG 1 -- us2k10--------
    rs1444632451,2
    --36320565(+) CACCCA/GGCCGG 1 -- us2k10--------
    rs60202331,2
    H--36320585(+) ATATTC/TTTATA 1 -- us2k14Minor allele frequency- T:0.00NS EA 404
    rs1865680151,2
    --36320610(+) AAAGAC/TACCCA 1 -- us2k10--------
    rs1148226901,2
    C,F--36320683(+) AACTAC/GCTTGC 1 -- us2k11Minor allele frequency- G:0.20WA 118
    rs1997618691,2
    --36320724(+) TCCAA-/TCTCTCT 1 -- us2k10--------
    rs1997819781,2
    --36320735(+) TCTCT-/CTTTTT 1 -- us2k10--------
    rs60128261,2
    C,F,A--36320736(+) TCTCtC/Tttttt 1 -- us2k1 trp35Minor allele frequency- T:0.20NA WA CSA 10
    rs1484014681,2
    C--36320894(+) GCTAAG/TTTTTG 1 -- us2k10--------
    rs1424902761,2
    --36320909(+) TTTTAC/GTAGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CTNNBL1 (36322408 - 36500531 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CTNNBL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722391CNV Deletion23290073
    esv2661276CNV Deletion23128226
    esv271662CNV Insertion20981092
    esv268096CNV Insertion20981092
    nsv3371CNV Insertion18451855
    nsv833970CNV Gain17160897
    dgv1326e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTNNBL1
    DNA2.0 Custom Variant and Variant Library Synthesis for CTNNBL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611537    OMIM disorders: --

    Selected diseases for CTNNBL1 (see all 23):    
    About MalaCards
    syringobulbia    syringomyelia    exfoliation syndrome    hyperphosphatemia
    nephroblastoma    obesity    pulmonary fibrosis    intrahepatic cholangiocarcinoma
    cholangiocarcinoma    nasopharyngitis    esophageal squamous cell carcinoma    esophagitis
    squamous cell carcinoma    asthma    ovarian cancer    colorectal cancer
    thyroiditis    melanoma    prostate cancer    prostatitis


    CTNNBL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CTNNBL1
    Human Genome Epidemiology (HuGE) Navigator: CTNNBL1 (9 documents)

    Export disorders for CTNNBL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTNNBL1 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with CTNNBL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence, gene structure, and expression pattern of CTNNBL1, a minor- class intron-containing gene - evidence for a role in apoptosis. (PubMed id 12659813)1, 2, 3, 9 Jabbour L.S.... Hering T.M. (Genomics 2003)
    2. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. (PubMed id 21385873)1, 2, 3 Ganesh K.... Neuberger M. (J. Biol. Chem. 2011)
    3. Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes. (PubMed id 19245693)1, 4, 9 Andreasen C.H....Hansen T. (BMC Med. Genet. 2009)
    4. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (J. Allergy Clin. Immunol. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Molecular architecture of the human Prp19/CDC5L complex. (PubMed id 20176811)1, 2 Grote M.... Luhrmann R. (Mol. Cell. Biol. 2010)
    7. Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. (PubMed id 20712903)1, 4 Morgan A.R....Mitchell E.A. (BMC Med. Genet. 2010)
    8. Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry. (PubMed id 19228371)1, 4 Vogel C.I....Hinney A. (BMC Med. Genet. 2009)
    9. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. (PubMed id 18722174)1, 2 Conticello S.G.... Neuberger M.S. (Mol. Cell 2008)
    10. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)1, 4 Kiel D.P....Karasik D. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 56259 HGNC: 15879 AceView: CTNNBL1 Ensembl:ENSG00000132792 euGenes: HUgn56259
    ECgene: CTNNBL1 Kegg: 56259 H-InvDB: CTNNBL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CTNNBL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTNNBL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CTNNBL1 gene:
    Search GeneIP for patents involving CTNNBL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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