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Aliases for CTNNBIP1 Gene

Aliases for CTNNBIP1 Gene

  • Catenin Beta Interacting Protein 1 2 3 5
  • Inhibitor Of Beta-Catenin And Tcf-4 2 3 4
  • Beta-Catenin-Interacting Protein ICAT 2 3
  • ICAT 3 4
  • Catenin, Beta-Interacting Protein 1 2
  • Catenin, Beta Interacting Protein 1 2
  • Beta-Catenin-Interacting Protein 1 3

External Ids for CTNNBIP1 Gene

Previous GeneCards Identifiers for CTNNBIP1 Gene

  • GC01M009869
  • GC01M009752
  • GC01M009517
  • GC01M009617
  • GC01M009842
  • GC01M009064
  • GC01M009908

Summaries for CTNNBIP1 Gene

Entrez Gene Summary for CTNNBIP1 Gene

  • The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTNNBIP1 Gene

CTNNBIP1 (Catenin Beta Interacting Protein 1) is a Protein Coding gene. Diseases associated with CTNNBIP1 include Keratocystic Odontogenic Tumor and Gastric Cancer, Somatic. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Signaling by Wnt. GO annotations related to this gene include beta-catenin binding and armadillo repeat domain binding. An important paralog of this gene is LZIC.

UniProtKB/Swiss-Prot for CTNNBIP1 Gene

  • Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.

Gene Wiki entry for CTNNBIP1 Gene

Additional gene information for CTNNBIP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTNNBIP1 Gene

Genomics for CTNNBIP1 Gene

Regulatory Elements for CTNNBIP1 Gene

Enhancers for CTNNBIP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H009908 1.3 ENCODE dbSUPER 14 -0.5 -502 4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 CTNNBIP1 RBP7 GC01M009926
GH01H009847 1.2 Ensembl ENCODE dbSUPER 14.6 +60.7 60745 3 RFX1 ETV1 ZSCAN4 ZIC2 NFIC ZNF316 ZNF341 MYNN ZNF624 NFYB CTNNBIP1 LZIC ENSG00000223989 LOC105376717
GH01H009881 0.7 ENCODE dbSUPER 23.3 +28.0 27960 1 NFIC ZFP3 ZIC2 CTNNBIP1 ENSG00000223989 ENSG00000228150 RN7SKP269 NMNAT1 LZIC RBP7 PIR35071
GH01H010063 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10 -155.2 -155173 4 HDGF FOXA2 RAD21 YY1 ZNF121 EGR1 FOS ATF7 RUNX3 CREM LZIC UBE4B RN7SKP269 NMNAT1 ENSG00000228150 ENSG00000223989 CTNNBIP1 RNU6-828P KIF1B PGAM1P11
GH01H009657 1.4 Ensembl ENCODE dbSUPER 10.4 +252.4 252404 1 HDGF TBP PKNOX1 ATF1 ARNT NFRKB FEZF1 NFXL1 BATF TCF12 CTNNBIP1 RPL26P7 PIK3CD-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CTNNBIP1 on UCSC Golden Path with GeneCards custom track

Promoters for CTNNBIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000001214 -164 1801 HDGF MLX ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207

Genomic Location for CTNNBIP1 Gene

Chromosome:
1
Start:
9,848,276 bp from pter
End:
9,910,336 bp from pter
Size:
62,061 bases
Orientation:
Minus strand

Genomic View for CTNNBIP1 Gene

Genes around CTNNBIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTNNBIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTNNBIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTNNBIP1 Gene

Proteins for CTNNBIP1 Gene

  • Protein details for CTNNBIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSA3-CNBP1_HUMAN
    Recommended name:
    Beta-catenin-interacting protein 1
    Protein Accession:
    Q9NSA3
    Secondary Accessions:
    • Q5T4V2

    Protein attributes for CTNNBIP1 Gene

    Size:
    81 amino acids
    Molecular mass:
    9170 Da
    Quaternary structure:
    • Binds CTNNB1.

    Three dimensional structures from OCA and Proteopedia for CTNNBIP1 Gene

neXtProt entry for CTNNBIP1 Gene

Post-translational modifications for CTNNBIP1 Gene

  • Ubiquitination at isoforms=19
  • Modification sites at PhosphoSitePlus

Other Protein References for CTNNBIP1 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for CTNNBIP1
  • Santa Cruz Biotechnology (SCBT) Antibodies for CTNNBIP1

No data available for DME Specific Peptides for CTNNBIP1 Gene

Domains & Families for CTNNBIP1 Gene

Gene Families for CTNNBIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CTNNBIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CTNNBIP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NSA3

UniProtKB/Swiss-Prot:

CNBP1_HUMAN :
  • Belongs to the CTNNBIP1 family.
Family:
  • Belongs to the CTNNBIP1 family.
genes like me logo Genes that share domains with CTNNBIP1: view

Function for CTNNBIP1 Gene

Molecular function for CTNNBIP1 Gene

UniProtKB/Swiss-Prot Function:
Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.

Phenotypes From GWAS Catalog for CTNNBIP1 Gene

Gene Ontology (GO) - Molecular Function for CTNNBIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12408824
GO:0008013 beta-catenin binding IPI 12408825
GO:0070016 armadillo repeat domain binding IPI 12408825
genes like me logo Genes that share ontologies with CTNNBIP1: view
genes like me logo Genes that share phenotypes with CTNNBIP1: view

Animal Models for CTNNBIP1 Gene

MGI Knock Outs for CTNNBIP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CTNNBIP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTNNBIP1 Gene

Localization for CTNNBIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTNNBIP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTNNBIP1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
mitochondrion 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Mitochondria (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CTNNBIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 18287330
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 19569129
GO:0005829 cytosol IDA 18287330
GO:0030877 beta-catenin destruction complex IDA 16188939
genes like me logo Genes that share ontologies with CTNNBIP1: view

Pathways & Interactions for CTNNBIP1 Gene

genes like me logo Genes that share pathways with CTNNBIP1: view

Pathways by source for CTNNBIP1 Gene

SIGNOR curated interactions for CTNNBIP1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CTNNBIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IBA --
GO:0002528 regulation of vascular permeability involved in acute inflammatory response IMP 18287330
GO:0009952 anterior/posterior pattern specification IBA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IBA --
genes like me logo Genes that share ontologies with CTNNBIP1: view

Drugs & Compounds for CTNNBIP1 Gene

No Compound Related Data Available

Transcripts for CTNNBIP1 Gene

Unigene Clusters for CTNNBIP1 Gene

Catenin, beta interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CTNNBIP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CTNNBIP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - - -
SP3:
SP4: - - - - -

Relevant External Links for CTNNBIP1 Gene

GeneLoc Exon Structure for
CTNNBIP1
ECgene alternative splicing isoforms for
CTNNBIP1

Expression for CTNNBIP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTNNBIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTNNBIP1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x9.4) and Skin - Not Sun Exposed (Suprapubic) (x6.7).

Protein differential expression in normal tissues from HIPED for CTNNBIP1 Gene

This gene is overexpressed in Cervix (47.9) and Skin (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CTNNBIP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CTNNBIP1 Gene:

CTNNBIP1

SOURCE GeneReport for Unigene cluster for CTNNBIP1 Gene:

Hs.463759

Evidence on tissue expression from TISSUES for CTNNBIP1 Gene

  • Lung(4.6)
  • Nervous system(4.6)
  • Stomach(2)
genes like me logo Genes that share expression patterns with CTNNBIP1: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTNNBIP1 Gene

Orthologs for CTNNBIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTNNBIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTNNBIP1 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia CTNNBIP1 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTNNBIP1 34
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctnnbip1 33
  • 95.06 (n)
cow
(Bos Taurus)
Mammalia CTNNBIP1 33 34
  • 93.83 (n)
mouse
(Mus musculus)
Mammalia Ctnnbip1 33 16 34
  • 93.83 (n)
dog
(Canis familiaris)
Mammalia CTNNBIP1 33 34
  • 92.59 (n)
chicken
(Gallus gallus)
Aves CTNNBIP1 33 34
  • 84.77 (n)
lizard
(Anolis carolinensis)
Reptilia CTNNBIP1 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctnnbip1 33
  • 81.07 (n)
zebrafish
(Danio rerio)
Actinopterygii ctnnbip1 33 34
  • 80.66 (n)
-- 33
Species where no ortholog for CTNNBIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTNNBIP1 Gene

ENSEMBL:
Gene Tree for CTNNBIP1 (if available)
TreeFam:
Gene Tree for CTNNBIP1 (if available)

Paralogs for CTNNBIP1 Gene

Paralogs for CTNNBIP1 Gene

(1) SIMAP similar genes for CTNNBIP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTNNBIP1: view

Variants for CTNNBIP1 Gene

Sequence variations from dbSNP and Humsavar for CTNNBIP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000090783 -- 9,883,118(+) GGGAC(A/G)GCGCA intron-variant
rs1000121087 -- 9,866,372(+) CCTCA(A/G)GGCAG intron-variant
rs1000138706 -- 9,864,389(+) AGTGG(C/T)GCGAT intron-variant
rs1000195035 -- 9,866,755(+) TGGGG(C/G)TAGAG intron-variant
rs1000198497 -- 9,898,999(+) CTTCC(A/G)TAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTNNBIP1 Gene

Variant ID Type Subtype PubMed ID
nsv1112518 CNV deletion 24896259
nsv545380 CNV loss 21841781

Variation tolerance for CTNNBIP1 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTNNBIP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTNNBIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTNNBIP1 Gene

Disorders for CTNNBIP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CTNNBIP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
keratocystic odontogenic tumor
  • ktoc
gastric cancer, somatic
  • gastric cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CTNNBIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTNNBIP1
genes like me logo Genes that share disorders with CTNNBIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTNNBIP1 Gene

Publications for CTNNBIP1 Gene

  1. Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. (PMID: 10898789) Tago K … Akiyama T (Genes & development 2000) 2 3 4 22 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Mutation and expression of the beta-catenin-interacting protein ICAT in human colorectal tumors. (PMID: 12417602) Koyama T … Akiyama T (Japanese journal of clinical oncology 2002) 3 22 60
  4. ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. (PMID: 12408825) Daniels DL … Weis WI (Molecular cell 2002) 3 4 60
  5. The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. (PMID: 12408824) Graham TA … Xu W (Molecular cell 2002) 3 4 60

Products for CTNNBIP1 Gene

Sources for CTNNBIP1 Gene

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