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CTNNBIP1 Gene

protein-coding   GIFtS: 59
GCID: GC01M009908

Catenin, Beta Interacting Protein 1

(Previous names: catenin, beta-interacting protein 1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Catenin, Beta Interacting Protein 11 2
Inhibitor Of Beta-Catenin And Tcf-41 2 3
ICAT2 3 5
Beta-Catenin-Interacting Protein ICAT1 2
Catenin, Beta-Interacting Protein 11
Beta-Catenin-Interacting Protein 12

External Ids:    HGNC: 169131   Entrez Gene: 569982   Ensembl: ENSG000001785857   OMIM: 6077585   UniProtKB: Q9NSA33   

Export aliases for CTNNBIP1 gene to outside databases

Previous GC identifers: GC01M009869 GC01M009752 GC01M009517 GC01M009617 GC01M009842 GC01M009064


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTNNBIP1 Gene:
The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The
encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same
protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CTNNBIP1 Gene:
CTNNBIP1 (catenin, beta interacting protein 1) is a protein-coding gene. GO annotations related to this gene include beta-catenin binding and armadillo repeat domain binding.

UniProtKB/Swiss-Prot: CNBP1_HUMAN, Q9NSA3
Function: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the
Wnt signaling pathway

Gene Wiki entry for CTNNBIP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTNNBIP1 gene promoter:
         E2F-4   E2F-3a   E2F-5   Sp1   p300   MyoD   E2F-2   E2F   E2F-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CTNNBIP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTNNBIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

CTNNBIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTNNBIP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M009908:  view genomic region     (about GC identifiers)

Start:
9,908,334 bp from pter      End:
9,970,394 bp from pter
Size:
62,061 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CNBP1_HUMAN, Q9NSA3 (See protein sequence)
Recommended Name: Beta-catenin-interacting protein 1  
Size: 81 amino acids; 9170 Da
Subunit: Binds CTNNB1
3 PDB 3D structures from and Proteopedia for CTNNBIP1:
1LUJ (3D)        1M1E (3D)        1T08 (3D)    
Secondary accessions: Q5T4V2

Explore the universe of human proteins at neXtProt for CTNNBIP1: NX_Q9NSA3

Explore proteomics data for CTNNBIP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys19
  • Modification sites at PhosphoSitePlus

  • See CTNNBIP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001012329.1  NP_064633.1  

    ENSEMBL proteins: 
     ENSP00000366474   ENSP00000383696   ENSP00000366468   ENSP00000366466   ENSP00000444681  
    Reactome Protein details: Q9NSA3

    CTNNBIP1 Human Recombinant Protein Products:

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    Novus Biologicals CTNNBIP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CTNNBIP1
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CTNNBIP1 (18 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009428 ICAT

    Graphical View of Domain Structure for InterPro Entry Q9NSA3

    ProtoNet protein and cluster: Q9NSA3

    UniProtKB/Swiss-Prot: CNBP1_HUMAN, Q9NSA3
    Similarity: Belongs to the CTNNBIP1 family


    Find genes that share domains with CTNNBIP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNBP1_HUMAN, Q9NSA3
    Function: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the
    Wnt signaling pathway

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12408824
    GO:0008013beta-catenin binding IPI12408825
    GO:0070016armadillo repeat domain binding IPI12408825
         
    Find genes that share ontologies with CTNNBIP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CTNNBIP1:
     Decreased POU5F1-GFP protein e 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ctnnbip1):
     cellular  craniofacial  digestive/alimentary  embryogenesis  mortality/aging 
     nervous system  renal/urinary system  respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with CTNNBIP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ctnnbip1tm1Taki for CTNNBIP1

       genOway: Develop your customized and physiologically relevant rodent model for CTNNBIP1

    miRNA
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    miRTarBase miRNAs that target CTNNBIP1:
    hsa-mir-192-5p (MIRT026964), hsa-mir-744-5p (MIRT037541), hsa-mir-335-5p (MIRT019224), hsa-mir-29b-3p (MIRT000097), hsa-mir-215-5p (MIRT007364)

    Block miRNA regulation of human, mouse, rat CTNNBIP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTNNBIP1 (see all 61):
    hsa-miR-4291 hsa-miR-3194-5p hsa-miR-328 hsa-miR-188-5p hsa-miR-15a hsa-miR-25 hsa-miR-29a hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidCTNNBIP1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNBIP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNBP1_HUMAN, Q9NSA3: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    cytoskeleton1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18287330
    GO:0005737cytoplasm IDA19569129
    GO:0005829cytosol IDA18287330
    GO:0030877beta-catenin destruction complex IDA16188939

    Find genes that share ontologies with CTNNBIP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTNNBIP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    Find genes that share SuperPaths with CTNNBIP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CTNNBIP1
        Wnt Signaling Pathway NetPath
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    1 Reactome Pathway for CTNNBIP1
        deactivation of the beta-catenin transactivating complex


    1 Kegg Pathway  (Kegg details for CTNNBIP1):
        Wnt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including CTNNBIP1: 
              WNT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CTNNBIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTNNBIP1 (Q9NSA31, 2, 3 ENSP000003664664) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUPP149232, 3, ENSP000003111134MINT-68465 I2D: score=6 STRING: ENSP00000311113
    CTNNB1P352221, 2, 3, ENSP000003444564EBI-747082,EBI-491549 MINT-58679 I2D: score=9 STRING: ENSP00000344456
    BEND5Q7L4P63, ENSP000003608994I2D: score=4 STRING: ENSP00000360899
    CASP4P496623, ENSP000003885664I2D: score=2 STRING: ENSP00000388566
    CPVLQ9H3G53, ENSP000002653944I2D: score=2 STRING: ENSP00000265394
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001658branching involved in ureteric bud morphogenesis IBA--
    GO:0002528regulation of vascular permeability involved in acute inflammatory response IMP18287330
    GO:0009952anterior/posterior pattern specification IBA--
    GO:0016055Wnt signaling pathway IEA--

    Find genes that share ontologies with CTNNBIP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTNNBIP1 (CNBP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTNNBIP1 gene (2 alternative transcripts): 
    NM_001012329.1  NM_020248.2  

    Unigene Cluster for CTNNBIP1:

    Catenin, beta interacting protein 1
    Hs.463759  [show with all ESTs]
    Unigene Representative Sequence: NM_020248
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377263(uc001aqk.1 uc001aql.1) ENST00000400904 ENST00000377258
    ENST00000377256 ENST00000537447
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CTNNBIP1 (see all 61):
    hsa-miR-4291 hsa-miR-3194-5p hsa-miR-328 hsa-miR-188-5p hsa-miR-15a hsa-miR-25 hsa-miR-29a hsa-miR-486-3p
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTNNBIP1
      QuantiTect SYBR Green Assays in human, mouse, rat CTNNBIP1
      QuantiFast Probe-based Assays in human, mouse, rat CTNNBIP1

    Additional mRNA sequence: 

    AB021262.1 BC014300.1 BC146892.1 BC146896.1 

    12 DOTS entries:

    DT.446332  DT.101956912  DT.95196692  DT.91746023  DT.75103793  DT.95196641  DT.100684839  DT.100052211 
    DT.92044437  DT.95151207  DT.99973022  DT.97777665 

    Selected AceView cDNA sequences (see all 244):

    BX097270 CR606136 CN479209 Z43111 CD675305 F13465 CD671708 BQ024402 
    BM463223 BM671879 BU541435 BC035794 BQ023951 AI284266 BQ682197 BQ892669 
    BM710433 BM021485 BM722128 BM052920 BQ879703 CR625094 BG676252 BF110265 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CTNNBIP1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                    -                                             
    SP2:                          -     -     -                           
    SP3:                                                                  
    SP4:              -     -     -     -     -                           


    ECgene alternative splicing isoforms for CTNNBIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTNNBIP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCGGAAGA
    CTNNBIP1 Expression
    About this image


    CTNNBIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
             Ureteric Bud
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Eye (Sensory Organs)
             Retina
    CTNNBIP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTNNBIP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.463759
        Pathway & Disease-focused RT2 Profiler PCR Array including CTNNBIP1: 
              WNT Signaling Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNBIP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CTNNBIP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctnnbip11 , 5 catenin beta interacting protein 11, 5 93.83(n)1
    97.53(a)1
      4 (79.66 cM)5
    670871  NM_001141930.11  NP_001135402.11 
     1495182365 
    chicken
    (Gallus gallus)
    Aves CTNNBIP11 catenin, beta interacting protein 1 84.77(n)
    97.53(a)
      771460  XM_001233909.3  XP_001233910.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTNNBIP16
    catenin, beta interacting protein 1
    93(a)
    1 ↔ 1
    LGh(190227-229856)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB046868.12   -- 79.93(n)    AB046868.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB046866.12   -- 81.47(n)   58117  AB046866.1 


    ENSEMBL Gene Tree for CTNNBIP1 (if available)
    TreeFam Gene Tree for CTNNBIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTNNBIP1 gene
    1 SIMAP similar gene for CTNNBIP1 using alignment to 1 protein entry:     CNBP1_HUMAN:
    LZIC

    Find genes that share paralogs with CTNNBIP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTNNBIP1 (see all 1200)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs764843261,2
    C--9913959(+) CTAGC-/TAGC  
            
    AAACT
    2 -- int10--------
    rs351124941,2
    C--9915313(+) TTTTT-/T/TT  
            
    GTAGA
    2 -- int10--------
    rs728558011,2
    C,F--9916953(+) GAGATG/CGGGGA 2 -- int11Minor allele frequency- C:0.50WA 2
    rs1871196161,2
    --9925681(+) TTTCAC/GCTTCC 2 -- ds50010--------
    rs1914573211,2
    --9925700(+) ACATAC/GAGCTA 2 -- ds50010--------
    rs12203961,2
    C,F,A,H--9925965(+) CCTTCT/CTAACG 2 -- ds500112Minor allele frequency- C:0.41NS EA NA WA CSA 785
    rs12203951,2
    C,F,H--9926113(+) GCCCAC/TGTGAT 2 -- ds500119Minor allele frequency- T:0.18NS EA NA WA CSA 2344
    rs1821724451,2
    --9926176(+) ACACAA/CGAACC 2 -- ds50010--------
    rs1891234751,2
    --9926300(+) TCATCA/GTTGTT 2 -- ut310--------
    rs151771,2
    C,F,H--9926326(+) GTGATC/TGTGAC 2 -- ut31 ese315Minor allele frequency- T:0.13EA NS WA 3382

    HapMap Linkage Disequilibrium report for CTNNBIP1 (9908334 - 9970394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CTNNBIP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871146CNV Loss21882294
    nsv871610CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTNNBIP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CTNNBIP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607758    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CTNNBIP1:
    Root resorption

    Find genes that share disorders with CTNNBIP1           About GenesLikeMe

    2 Novoseek inferred disease relationships for CTNNBIP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 3.56 9 15492799 (2), 12417602 (1)
    cancer 0 3 15492799 (2), 12417602 (1)


    Export disorders for CTNNBIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTNNBIP1 gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with CTNNBIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. (PubMed id 10898789)1, 2, 3, 9 Tago K.... Akiyama T. (Genes Dev. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. (PubMed id 12408825)1, 2 Daniels D.L. and Weis W.I. (Mol. Cell 2002)
    4. The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. (PubMed id 12408824)1, 2 Graham T.A.... Xu W. (Mol. Cell 2002)
    5. Mutation and expression of the beta-catenin-interacting protein ICAT in human colorectal tumors. (PubMed id 12417602)1, 9 Koyama T....Akiyama T. (Jpn. J. Clin. Oncol. 2002)
    6. ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours. (PubMed id 23339455)1 Campos M.L....Real F.X. (Biochem. J. 2013)
    7. Beta-catenin and survivin expression in keratocystic odontogenic tumor (KCOT). A comparative immunohistochemical study in primary, recurrent and nevoid basal cell carcinoma syndrome (NBCCS)-associated lesions. (PubMed id 23572266)1 Leonardi R....Pannone G. (Histol. Histopathol. 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Nuclear I^-catenin accumulation is associated with increased expression of Nanog protein and predicts poor prognosis of non-small cell lung cancer. (PubMed id 23648139)1 Li X.Q....Xiao G.H. (J Transl Med 2013)
    10. Intersection of Hippo/YAP and Wnt/I^-catenin signaling pathways. (PubMed id 23027379)1 Konsavage W.M. and Yochum G.S. (Acta Biochim. Biophys. Sin. (Shanghai) 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 56998 HGNC: 16913 AceView: CTNNBIP1 Ensembl:ENSG00000178585 euGenes: HUgn56998
    ECgene: CTNNBIP1 Kegg: 56998 H-InvDB: CTNNBIP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CTNNBIP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTNNBIP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CTNNBIP1 gene:
    Search GeneIP for patents involving CTNNBIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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