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Aliases for CTNNBIP1 Gene

Aliases for CTNNBIP1 Gene

  • Catenin Beta Interacting Protein 1 2 3 5
  • Inhibitor Of Beta-Catenin And Tcf-4 2 3 4
  • Beta-Catenin-Interacting Protein ICAT 2 3
  • Catenin, Beta Interacting Protein 1 2 3
  • ICAT 3 4
  • Catenin, Beta-Interacting Protein 1 2

External Ids for CTNNBIP1 Gene

Previous GeneCards Identifiers for CTNNBIP1 Gene

  • GC01M009869
  • GC01M009752
  • GC01M009517
  • GC01M009617
  • GC01M009842
  • GC01M009064
  • GC01M009908

Summaries for CTNNBIP1 Gene

Entrez Gene Summary for CTNNBIP1 Gene

  • The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CTNNBIP1 Gene

CTNNBIP1 (Catenin Beta Interacting Protein 1) is a Protein Coding gene. Diseases associated with CTNNBIP1 include keratocystic odontogenic tumor and gastric cancer, somatic. Among its related pathways are Signaling by GPCR and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include beta-catenin binding and armadillo repeat domain binding.

UniProtKB/Swiss-Prot for CTNNBIP1 Gene

  • Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.

Gene Wiki entry for CTNNBIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTNNBIP1 Gene

Genomics for CTNNBIP1 Gene

Regulatory Elements for CTNNBIP1 Gene

Promoters for CTNNBIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CTNNBIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CTNNBIP1 Gene

Chromosome:
1
Start:
9,848,276 bp from pter
End:
9,910,336 bp from pter
Size:
62,061 bases
Orientation:
Minus strand

Genomic View for CTNNBIP1 Gene

Genes around CTNNBIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTNNBIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTNNBIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTNNBIP1 Gene

Proteins for CTNNBIP1 Gene

  • Protein details for CTNNBIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSA3-CNBP1_HUMAN
    Recommended name:
    Beta-catenin-interacting protein 1
    Protein Accession:
    Q9NSA3
    Secondary Accessions:
    • Q5T4V2

    Protein attributes for CTNNBIP1 Gene

    Size:
    81 amino acids
    Molecular mass:
    9170 Da
    Quaternary structure:
    • Binds CTNNB1.

    Three dimensional structures from OCA and Proteopedia for CTNNBIP1 Gene

neXtProt entry for CTNNBIP1 Gene

Proteomics data for CTNNBIP1 Gene at MOPED

Post-translational modifications for CTNNBIP1 Gene

  • Ubiquitination at Lys 19
  • Modification sites at PhosphoSitePlus

Other Protein References for CTNNBIP1 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for CTNNBIP1

No data available for DME Specific Peptides for CTNNBIP1 Gene

Domains & Families for CTNNBIP1 Gene

Protein Domains for CTNNBIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CTNNBIP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NSA3

UniProtKB/Swiss-Prot:

CNBP1_HUMAN :
  • Belongs to the CTNNBIP1 family.
Family:
  • Belongs to the CTNNBIP1 family.
genes like me logo Genes that share domains with CTNNBIP1: view

No data available for Gene Families for CTNNBIP1 Gene

Function for CTNNBIP1 Gene

Molecular function for CTNNBIP1 Gene

UniProtKB/Swiss-Prot Function:
Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.
genes like me logo Genes that share phenotypes with CTNNBIP1: view

Animal Models for CTNNBIP1 Gene

MGI Knock Outs for CTNNBIP1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTNNBIP1 Gene

Localization for CTNNBIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTNNBIP1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTNNBIP1 Gene COMPARTMENTS Subcellular localization image for CTNNBIP1 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 2
plasma membrane 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for CTNNBIP1 Gene

Pathways & Interactions for CTNNBIP1 Gene

genes like me logo Genes that share pathways with CTNNBIP1: view

Pathways by source for CTNNBIP1 Gene

SIGNOR curated interactions for CTNNBIP1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CTNNBIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IBA --
GO:0009952 anterior/posterior pattern specification IBA --
GO:0016055 Wnt signaling pathway IEA --
GO:0032091 negative regulation of protein binding IDA 12408825
GO:0043392 negative regulation of DNA binding IEA --
genes like me logo Genes that share ontologies with CTNNBIP1: view

Drugs & Compounds for CTNNBIP1 Gene

No Compound Related Data Available

Transcripts for CTNNBIP1 Gene

Unigene Clusters for CTNNBIP1 Gene

Catenin, beta interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTNNBIP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - - -
SP3:
SP4: - - - - -

Relevant External Links for CTNNBIP1 Gene

GeneLoc Exon Structure for
CTNNBIP1
ECgene alternative splicing isoforms for
CTNNBIP1

Expression for CTNNBIP1 Gene

mRNA expression in normal human tissues for CTNNBIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTNNBIP1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x9.4) and Skin - Not Sun Exposed (Suprapubic) (x6.7).

Protein differential expression in normal tissues from HIPED for CTNNBIP1 Gene

This gene is overexpressed in Cervix (47.9) and Skin (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CTNNBIP1 Gene



SOURCE GeneReport for Unigene cluster for CTNNBIP1 Gene Hs.463759

genes like me logo Genes that share expression patterns with CTNNBIP1: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CTNNBIP1 Gene

Orthologs for CTNNBIP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTNNBIP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTNNBIP1 35
  • 93.83 (n)
  • 97.53 (a)
CTNNBIP1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTNNBIP1 35
  • 92.59 (n)
  • 97.53 (a)
CTNNBIP1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctnnbip1 35
  • 93.83 (n)
  • 97.53 (a)
Ctnnbip1 16
Ctnnbip1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTNNBIP1 35
  • 100 (n)
  • 100 (a)
CTNNBIP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctnnbip1 35
  • 95.06 (n)
  • 98.77 (a)
oppossum
(Monodelphis domestica)
Mammalia CTNNBIP1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTNNBIP1 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTNNBIP1 35
  • 84.77 (n)
  • 97.53 (a)
CTNNBIP1 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTNNBIP1 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctnnbip1 35
  • 81.07 (n)
  • 92.59 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ctnnbip1 35
  • 80.66 (n)
  • 87.65 (a)
ctnnbip1 36
  • 86 (a)
OneToOne
Species with no ortholog for CTNNBIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTNNBIP1 Gene

ENSEMBL:
Gene Tree for CTNNBIP1 (if available)
TreeFam:
Gene Tree for CTNNBIP1 (if available)

Paralogs for CTNNBIP1 Gene

(1) SIMAP similar genes for CTNNBIP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CTNNBIP1: view

No data available for Paralogs for CTNNBIP1 Gene

Variants for CTNNBIP1 Gene

Sequence variations from dbSNP and Humsavar for CTNNBIP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7225 -- 9,848,622(-) TCCCC(A/G)CTCAG utr-variant-3-prime
rs14339 -- 9,848,530(+) GGCCT(C/T)GACAC utr-variant-3-prime
rs15177 -- 9,848,424(+) GTGAT(C/T)GTGAC utr-variant-3-prime
rs935073 -- 9,863,683(+) CCAAC(A/G)TAAGG intron-variant
rs935074 -- 9,869,909(+) GGGGC(A/G)GGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTNNBIP1 Gene

Variant ID Type Subtype PubMed ID
nsv871610 CNV Gain 21882294
nsv871146 CNV Loss 21882294

Variation tolerance for CTNNBIP1 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTNNBIP1 Gene

HapMap Linkage Disequilibrium report
CTNNBIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTNNBIP1 Gene

Disorders for CTNNBIP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CTNNBIP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
keratocystic odontogenic tumor
  • ktoc
gastric cancer, somatic
  • gastric cancer
actinic cheilitis
  • actinic cheilosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CTNNBIP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTNNBIP1
genes like me logo Genes that share disorders with CTNNBIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CTNNBIP1 Gene

Publications for CTNNBIP1 Gene

  1. Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. (PMID: 10898789) Tago K. … Akiyama T. (Genes Dev. 2000) 2 3 4 23 67
  2. Mutation and expression of the beta-catenin-interacting protein ICAT in human colorectal tumors. (PMID: 12417602) Koyama T. … Akiyama T. (Jpn. J. Clin. Oncol. 2002) 3 23
  3. ICAT inhibits glioblastoma cell proliferation by suppressing Wnt/I^-catenin activity. (PMID: 25434796) Zhang K. … Kang C. (Cancer Lett. 2015) 3
  4. miR-603 promotes glioma cell growth via Wnt/I^-catenin pathway by inhibiting WIF1 and CTNNBIP1. (PMID: 25681036) Guo M. … Zheng Y. (Cancer Lett. 2015) 3
  5. Simultaneous silencing of I^a89catenin and signal transducer and activator of transcriptionA 3 synergistically induces apoptosis and inhibits cell proliferation in HepG2 liver cancer cells. (PMID: 25845340) Wang X.H. … Xu R.L. (Mol Med Rep 2015) 3

Products for CTNNBIP1 Gene

Sources for CTNNBIP1 Gene

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