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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTNNBIP1 Gene

protein-coding   GIFtS: 58
GCID: GC01M009908

Catenin, Beta Interacting Protein 1

(Previous names: catenin, beta-interacting protein 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Catenin, Beta Interacting Protein 11 2
Inhibitor Of Beta-Catenin And Tcf-41 2 3
ICAT2 3 5
Beta-Catenin-Interacting Protein ICAT1 2
Catenin, Beta-Interacting Protein 11
Beta-Catenin-Interacting Protein 12

External Ids:    HGNC: 169131   Entrez Gene: 569982   Ensembl: ENSG000001785857   OMIM: 6077585   UniProtKB: Q9NSA33   
ORGUL members:         
NONCODE14:n337710      

Export aliases for CTNNBIP1 gene to outside databases

Previous GC identifers: GC01M009869 GC01M009752 GC01M009517 GC01M009617 GC01M009842 GC01M009064


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTNNBIP1 Gene:
The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The
encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same
protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CTNNBIP1 Gene: 
CTNNBIP1 (catenin, beta interacting protein 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CTNNBIP1 include desmoid tumor, and actinic cheilitis, and among its related super-pathways are Wnt Signaling Pathway. GO annotations related to this gene include beta-catenin binding and armadillo repeat domain binding.

UniProtKB/Swiss-Prot: CNBP1_HUMAN, Q9NSA3
Function: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the
Wnt signaling pathway

Gene Wiki entry for CTNNBIP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTNNBIP1 gene promoter:
         E2F-4   E2F-3a   E2F-5   Sp1   p300   MyoD   E2F-2   E2F   E2F-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CTNNBIP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTNNBIP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

CTNNBIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTNNBIP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M009908:  view genomic region     (about GC identifiers)

Start:
9,908,334 bp from pter      End:
9,970,394 bp from pter
Size:
62,061 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CNBP1_HUMAN, Q9NSA3 (See protein sequence)
Recommended Name: Beta-catenin-interacting protein 1  
Size: 81 amino acids; 9170 Da
Subunit: Binds CTNNB1
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
3 PDB 3D structures from and Proteopedia for CTNNBIP1:
1LUJ (3D)        1M1E (3D)        1T08 (3D)    
Secondary accessions: Q5T4V2

Explore the universe of human proteins at neXtProt for CTNNBIP1: NX_Q9NSA3

Explore proteomics data for CTNNBIP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NSA3

  • CTNNBIP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CTNNBIP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001012329.1  NP_064633.1  

    ENSEMBL proteins: 
     ENSP00000366474   ENSP00000383696   ENSP00000366468   ENSP00000366466   ENSP00000444681  

    Human Recombinant Protein Products for CTNNBIP1: 
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    Novus Biologicals CTNNBIP1 Proteins
    Novus Biologicals CTNNBIP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CTNNBIP1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18287330
    GO:0005737cytoplasm IDA19569129
    GO:0005829cytosol IDA18287330
    GO:0030877beta-catenin destruction complex IDA16188939

    CTNNBIP1 for ontologies           About GeneDecksing



    CTNNBIP1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009428 ICAT

    Graphical View of Domain Structure for InterPro Entry Q9NSA3

    ProtoNet protein and cluster: Q9NSA3

    UniProtKB/Swiss-Prot: CNBP1_HUMAN, Q9NSA3
    Similarity: Belongs to the CTNNBIP1 family


    CTNNBIP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNBP1_HUMAN, Q9NSA3
    Function: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the
    Wnt signaling pathway

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12408824
    GO:0008013beta-catenin binding IPI12408825
    GO:0070016armadillo repeat domain binding IPI12408825
         
    CTNNBIP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CTNNBIP1:
     Decreased POU5F1-GFP protein e 

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ctnnbip1):
     cellular  craniofacial  digestive/alimentary  embryogenesis  mortality/aging 
     nervous system  renal/urinary system  respiratory system  skeleton  vision/eye 

    CTNNBIP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ctnnbip1tm1Taki for CTNNBIP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CTNNBIP1 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidCTNNBIP1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CTNNBIP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    2Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CTNNBIP1
        Wnt Signaling Pathway NetPath
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    1         Kegg Pathway  (Kegg details for CTNNBIP1):
        Wnt signaling pathway


    CTNNBIP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTNNBIP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for CTNNBIP1 (Q9NSA31, 2, 3 ENSP000003664664) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUPP149232, 3, ENSP000003111134MINT-68465 I2D: score=6 STRING: ENSP00000311113
    CTNNB1P352221, 2, 3, ENSP000003444564EBI-747082,EBI-491549 MINT-58679 I2D: score=9 STRING: ENSP00000344456
    BEND5Q7L4P63, ENSP000003608994I2D: score=4 STRING: ENSP00000360899
    CASP4P496623, ENSP000003885664I2D: score=2 STRING: ENSP00000388566
    CPVLQ9H3G53, ENSP000002653944I2D: score=2 STRING: ENSP00000265394
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001658branching involved in ureteric bud morphogenesis IBA--
    GO:0002528regulation of vascular permeability involved in acute inflammatory response IMP18287330
    GO:0009952anterior/posterior pattern specification IBA--
    GO:0016055Wnt receptor signaling pathway IEA--

    CTNNBIP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTNNBIP1 (CNBP1)

    Search CenterWatch for drugs/clinical trials and news about CTNNBIP1 / CNBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CTNNBIP1 gene (2 alternative transcripts): 
    NM_001012329.1  NM_020248.2  

    Unigene Cluster for CTNNBIP1:

    Catenin, beta interacting protein 1
    Hs.463759  [show with all ESTs]
    Unigene Representative Sequence: NM_020248
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377263(uc001aqk.1 uc001aql.1) ENST00000400904 ENST00000377258
    ENST00000377256 ENST00000537447
    miRNA
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    hsa-miR-4291 hsa-miR-3194-5p hsa-miR-328 hsa-miR-188-5p hsa-miR-15a hsa-miR-25 hsa-miR-29a hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidCTNNBIP1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTNNBIP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTNNBIP1

    Additional mRNA sequence: 

    AB021262.1 BC014300.1 BC146892.1 BC146896.1 

    12 DOTS entries:

    DT.446332  DT.101956912  DT.95196692  DT.91746023  DT.75103793  DT.95196641  DT.100684839  DT.100052211 
    DT.92044437  DT.95151207  DT.99973022  DT.97777665 

    24/244 AceView cDNA sequences (see all 244):

    BQ023951 BG676252 BM710433 BM021485 BX097270 BQ879703 BC035794 BM722128 
    BM671879 BQ024402 CD671708 F13465 BM463223 CR625094 BU541435 BM052920 
    CD675305 CN479209 AI284266 CR606136 Z43111 BQ682197 BQ892669 BI252220 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CTNNBIP1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                    -                                             
    SP2:                          -     -     -                           
    SP3:                                                                  
    SP4:              -     -     -     -     -                           


    ECgene alternative splicing isoforms for CTNNBIP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTNNBIP1 expression in normal human tissues (normalized intensities)      CTNNBIP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCGGAAGA
    CTNNBIP1 Expression
    About this image


    CTNNBIP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
             Ureteric Bud
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal progenitor cell p0   
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Placenta (Extraembryonic Tissues)

    See CTNNBIP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTNNBIP1

    SOURCE GeneReport for Unigene cluster: Hs.463759
        SABiosciences Expression via Pathway-Focused PCR Array including CTNNBIP1: 
              WNT Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNBIP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CTNNBIP1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctnnbip11 , 5 catenin beta interacting protein 11, 5 93.83(n)1
    97.53(a)1
      4 (79.66 cM)5
    670871  NM_001141930.11  NP_001135402.11 
     1495182365 
    chicken
    (Gallus gallus)
    Aves CTNNBIP11 catenin, beta interacting protein 1 84.77(n)
    97.53(a)
      771460  XM_001233909.2  XP_001233910.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTNNBIP16
    Uncharacterized protein
    93(a)
    1 ↔ 1
    LGh(190227-229856)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB046868.12   -- 79.93(n)    AB046868.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB046866.12   -- 81.47(n)   58117  AB046866.1 


    ENSEMBL Gene Tree for CTNNBIP1 (if available)
    TreeFam Gene Tree for CTNNBIP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTNNBIP1 gene
    1 SIMAP similar gene for CTNNBIP1 using alignment to 1 protein entry:     CNBP1_HUMAN:
    LZIC

    CTNNBIP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1200 SNPs in CTNNBIP1 are shown (see all 1200)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs764843261,2
    C--9913959(+) CTAGC-/TAGC  
            
    AAACT
    2 -- int10--------
    rs351124941,2
    C--9915313(+) TTTTT-/T/TT  
            
    GTAGA
    2 -- int10--------
    rs728558011,2
    C,F--9916953(+) GAGATG/CGGGGA 2 -- int11Minor allele frequency- C:0.50WA 2
    rs1871196161,2
    --9925681(+) TTTCAC/GCTTCC 2 -- ds50010--------
    rs1914573211,2
    --9925700(+) ACATAC/GAGCTA 2 -- ds50010--------
    rs12203961,2
    C,F,A,H--9925965(+) CCTTCT/CTAACG 2 -- ds500112Minor allele frequency- C:0.41NS EA NA WA CSA 785
    rs12203951,2
    C,F,H--9926113(+) GCCCAC/TGTGAT 2 -- ds500119Minor allele frequency- T:0.18NS EA NA WA CSA 2344
    rs1821724451,2
    --9926176(+) ACACAA/CGAACC 2 -- ds50010--------
    rs1891234751,2
    --9926300(+) TCATCA/GTTGTT 2 -- ut310--------
    rs151771,2
    C,F,H--9926326(+) GTGATC/TGTGAC 2 -- ut31 ese315Minor allele frequency- T:0.13EA NS WA 3382

    HapMap Linkage Disequilibrium report for CTNNBIP1 (9908334 - 9970394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CTNNBIP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv871146CNV Loss21882294
    nsv871610CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607758    OMIM disorders: --

    20/24 diseases for CTNNBIP1 (see all 24):    About MalaCards
    desmoid tumor    actinic cheilitis    cheilitis    duodenitis
    wilms tumor    malignant glioma    esophageal squamous cell carcinoma    endometrial carcinoma
    medulloblastoma    nasopharyngitis    acute lymphoblastic leukemia    laryngitis
    lymphoblastic leukemia    astrocytoma    esophagitis    squamous cell carcinoma
    gastric cancer    colorectal cancer    hepatocellular carcinoma    melanoma

    1 disease from the University of Copenhagen DISEASES database for CTNNBIP1:
    Root resorption

    CTNNBIP1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CTNNBIP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 3.56 9 15492799 (2), 12417602 (1)
    cancer 0 3 15492799 (2), 12417602 (1)


    Export disorders for CTNNBIP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTNNBIP1 gene, integrated from 9 sources (see all 77):
    (articles sorted by number of sources associating them with CTNNBIP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. (PubMed id 10898789)1, 2, 3, 9 Tago K.... Akiyama T. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. (PubMed id 12408825)1, 2 Daniels D.L. and Weis W.I. (2002)
    4. The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. (PubMed id 12408824)1, 2 Graham T.A.... Xu W. (2002)
    5. Mutation and expression of the beta-catenin-interacting protein ICAT in human colorectal tumors. (PubMed id 12417602)1, 9 Koyama T....Akiyama T. (2002)
    6. ICAT is a novel Ptf1a interactor that regulates pancre atic acinar differentiation and displays altered expression in tumours. (PubMed id 23339455)1 Campos M.L....Real F.X. (2013)
    7. Intersection of Hippo/YAP and Wnt/b-catenin signaling pathways. (PubMed id 23027379)1 Konsavage W.M. and Yochum G.S. (2013)
    8. E-cadherin and b-catenin expression in well-differenti ated and moderately-differentiated oral squamous cell carcinoma: relations with clinical variables. (PubMed id 22525043)1 Rosado P....de Vicente J.C. (2013)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. b-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesen chymal transition. (PubMed id 22081448)1 Giangreco A....Janes S.M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56998 HGNC: 16913 AceView: CTNNBIP1 Ensembl:ENSG00000178585 euGenes: HUgn56998
    ECgene: CTNNBIP1 Kegg: 56998 H-InvDB: CTNNBIP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTNNBIP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTNNBIP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CTNNBIP1 gene:
    Search GeneIP for patents involving CTNNBIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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