CTNNB1 Gene
protein-coding GIFtS : 73 GCID: GC03 P041236
catenin (cadherin-associated protein), beta 1, 88kDa catenin (cadherin-associated protein), beta 1 (88kD) )CTNNB )
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Aliasesfor CTNNB1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Catenin (Cadherin-Associated Protein), Beta 1, 88kDa 1 2 Catenin (Cadherin-Associated Protein), Beta 1 (88kD)1 CTNNB1 2 3 MRD192 Armadillo1 Catenin Beta-12 Beta-Catenin1 Beta-Catenin1
Export aliases for CTNNB1 gene to outside databases Previous GC identifers: GC03P040551 GC03P041054 GC03P041201 GC03P041216
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Summariesfor CTNNB1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CTNNB1 : The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.(provided by RefSeq, Oct 2009) UniProtKB/Swiss-Prot: CTNB1_HUMAN, P35222 Function : Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex withAXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 summary
for CTNNB1 : beta-catenin protein is an integral part of the canonical Wnt signalling pathway. Wnt binding to Frizzled(Fz) receptors and LRP co-receptors activates Dishevelled (Dsh) proteins; these in turn inhibit thedestruction complex responsible for degrading beta-catenin, which includes GSK-3, adenomatous polyposis coli(APC) and axin. Accumulation of beta-catenin in the cell cytoplasm prompts its translocation to the nucleus,where it interacts with members of the TCF/LEF family of transcription factors and induces the transcriptionof Wnt target genes. Gene Wiki entry for CTNNB1 (Beta-catenin)
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Genomic Viewsfor CTNNB1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_022517.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CTNNB1 gene promoter:p53 ATF-2 p300 CUTL1 GATA-2 Evi-1 E47 GATA-1 HOXA5 Other transcription factors Search SABiosciences Chromatin IP Primers for CTNNB1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p21 Ensembl cytogenetic band: 3p22.1 HGNC cytogenetic band: 3p21 CTNNB1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P041236: view genomic region
(about GC identifiers )
Start: 41,236,328 bp from pter End:
41,301,587 bp from pter
Size: 65,260 bases Orientation:
plus strand
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Proteinsfor CTNNB1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CTNB1_HUMAN, P35222 See
protein sequence )Recommended Name: Size : 781 amino acids; 85497 DaSubunit : Two separate complex-associated pools are found in the cytoplasm. The majority is present as component of anE-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and beta-catenin/CTNNB1, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Another cytoplasmic pool is part of a large complex containing AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. Wnt-dependent activation of DVL antagonizes the action of GSK3B. When GSK3B activity is inhibited the complex dissociates, CTNNB1 is dephosphorylated and is no longer targeted for destruction. The stabilized protein translocates to the nucleus, where it binds TCF/LEF-1 family members, TBP, BCL9 and possibly also RUVBL1 and CHD8. Binds CTNNBIP and EP300. CTNNB1 forms a ternary complex with LEF1 and EP300 that is disrupted by CTNNBIP1 binding (By similarity). Interacts with TAX1BP3 (via the PDZ domain); this interaction inhibits the transcriptional activity of CTNNB1 (By similarity). Interacts with AJAP1, BAIAP1, CARM1, CTNNA3, CXADR and PCDH11Y. Binds SLC9A3R1. Interacts with GLIS2 and MUC1. Interacts with SLC30A9. Interacts with XIRP1 (By similarity). Interacts directly with AXIN1; the interaction is regulated by CDK2 phosphorylation of AXIN1 (By similarity). Interacts with SCRIB (By similarity). Interacts with PTPRU (via the cytoplasmic juxtamembrane domain). Interacts with EMD. Interacts with TNIK and TCF7L2. Interacts with SESTD1 and TRPC4. Interacts with CAV1. Interacts with TRPV4. The TRPV4 and CTNNB1 complex can interact with CDH1. Interacts with VCL (By similarity). Interacts with PTPRJ. Interacts with PKT7 and CDK2. Interacts with FAT1 (via the cytoplasmic domain) (By similarity). Interacts with NANOS1 and NDRG2. Interacts with isoform 1 of NEK2. Interacts with both isoform 1 and isoform 2 of CDK5. Interacts with PTK6. Interacts with SOX7; this interaction may lead to proteasomal degradation of active CTNNB1 and thus inhibition of Wnt/beta-catenin-stimulated transcription. Identified in a complex with HINT1 and MITF. Interacts with FHIT
Subcellular location : Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction.Cell membrane. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Co-localizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells
Sequence caution : Sequence=BAB93475.1; Type=Erroneous initiation; Note=Translation N-terminally extended;6/18 PDB 3D structures from (see all 18 ):1G3J (3D) 1JDH (3D) 1JPW (3D) 1LUJ (3D) 1P22 (3D) 1QZ7 (3D) Secondary accessions : A8K1L7 Q8NEW9 Q8NI94 Q9H391Alternative splicing : 2 isoforms : P35222-1 P35222-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CTNNB1: NX_P35222 Post-translational modifications:
Phosphorylation at Ser-552 by AMPK promotes stabilizion of the protein, enhancing TCF/LEF-mediated transcription (By similarity). Phosphorylation by GSK3B requires prior phosphorylation of Ser-45 by another kinase. Phosphorylation proceeds then from Thr-41 to Ser-37 and Ser-33. Phosphorylated by NEK2. EGF stimulates tyrosine phosphorylation. Phosphorylation on Tyr-654 decreases CDH1 binding and enhances TBP binding. Phosphorylated on Ser-33 and Ser-37 by HIPK2. This phosphorylation triggers proteasomal degradation. Phosphorylation on Ser-191 and Ser-246 by CDK5. Phosphorylation by CDK2 regulates insulin internalization. Phosphorylation by PTK6 at Tyr-64, Tyr-142, Tyr-331 and/or Tyr-333 with the predominant site at Tyr-64 is not essential for inhibition of transcriptional activity1
Ubiquitinated by the SCF(BTRC) E3 ligase complex when phosphorylated by GSK3B, leading to its degradation. Ubiquitinated by a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X, leading to its subsequent proteasomal degradation (By similarity)1
S-nitrosylation at Cys-619 within adherens junctions promotes VEGF-induced, NO-dependent endothelial cell permeability by disrupting interaction with E-cadherin, thus mediating disassembly adherens junctions (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P35222 CTNNB1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (3 alternative transcripts): NP_001091679.1 NP_001091680.1 NP_001895.1 ENSEMBL proteins: ENSP00000400508 ENSP00000385604 ENSP00000387455 ENSP00000412219 ENSP00000379486 ENSP00000344456 ENSP00000411226 ENSP00000379488 ENSP00000409302 ENSP00000401599 Reactome Protein details: P35222 Human Recombinant Protein Products: Gene Ontology (GO): 5/38 cellular component terms (GO ID links to tree view) (see all 38 ): About this table
About GeneDecksing CTNNB1 Antibody Products: Assay Products for CTNNB1:
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Protein
Domains /for CTNNB1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P35222 ProtoNet protein and cluster: P35222
2 Blocks protein families : IPB000225 IPB000357 UniProtKB/Swiss-Prot: CTNB1_HUMAN, P35222 Similarity : Belongs to the beta-catenin familySimilarity : Contains 12 ARM repeats
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Functionfor CTNNB1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CTNB1_HUMAN, P35222 Function : Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex withAXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2
Genatlas biochemistry entry for CTNNB1 catenin beta 188 kDa,desmosomal plaque component,localized to the nucleus,regulating cell adhesion (component of the E cadherin multiprotein complex,homologous to plakoglobin (CTNNG1) and Drosophila Armadillo segment polarity gene),negatively regulated by APC,transducing wingless signals,interacting with LEF1and TCF4 components,a targetting AP-1 transcription complex,urokinase and presinilin 1 (PSEN1),involved in hair development with aberrant beta catenin in murine hair tumors,mutated in melanoma cell lines in anaplastic thyroid carcinoma in Wilms tumors,some colon,non polyposis colorectal,gastric or endometrioid ovarian carcinomas early onset type,in desmoid tumors without familial adenomatous polyposis,prostate cancer pilomatricomas and in hepatoblastomas and in Wilms tumor (see TSG3C),mutated or dysregulated in sporadic agressive fibromatosis(desmoid tumor) without familial adenomatous polyposis Inhib. RNA EMD Millipore RNAi Products for the Analysis of CTNNB1 Gene knock-down OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat see all 7 )CTNNB1 CTNNB1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 7 )human mouse rat see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): CTNNB1 (NM_001904 ) Sino Biological Human cDNA Clone for CTNNB1 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTNNB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CTNNB1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNB1
Gene Ontology (GO): 5/29 molecular function terms (GO ID links to tree view) (see all 29 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001102 RNA polymerase II activating transcription factor binding
IPI 19443654 GO:0003677 DNA binding
-- -- GO:0003682 chromatin binding
IEA -- GO:0003690 double-stranded DNA binding
IEA -- GO:0003700 sequence-specific DNA binding transcription factor activity
IEA --
About GeneDecksing 6 GenomeRNAi human phenotypes for CTNNB1 :Animal Models: Ctnnb1 tm4.1Wbm Ctnnb1 tm2.1Kem Ctnnb1 tm1Wbm Ctnnb1 tm1.1Yy 15/29 MGI mutant phenotypes (inferred from 21 alleles(MGI details for Ctnnb1) (see all 29 ):About GeneDecksing
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Pathways & Interactionsfor CTNNB1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/84 super-pathways (see all 84 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Wnt Signaling Pathway 2 Endometrial cancer 3 Activation of p38 alpha/beta MAPK 4 Cell-cell junction organization 5 Ubiquitinated Orc1 is degraded by the proteasome
Pathway sources See GeneCards unified pathways Show all pathways 5/12 (see all 12 )1 5/25 (see all 25 )2 2 5/14 (see all 14 )5/37 (see all 37 ) 5/18 (see all 18 )1 CTNNB1 5/15 (Kegg details for CTNNB1) (see all 15 ):About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTNNB1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/582 Interacting proteins for CTNNB1 (P35222 1 , 2 , 3 ENSP00000344456 4 via UniProtKB, MINT, STRING , and/or I2D (see all 582 )Interactant Interaction Details GeneCard External ID(s) AXIN1 O15169 1 , 2 , 3 ENSP00000262320 4 EBI-491549,EBI-710484 MINT-8284998 MINT-4508192 MINT-4508119 MINT-6823820 MINT-8277609 MINT-4508242 MINT-8403910 MINT-8403880 I2D:
score=9 STRING: ENSP00000262320 FERMT2 Q96AC1 2 MINT-8399030 MINT-8398724 MINT-8398831 MINT-8398987 MINT-8398882 MINT-8398896 MINT-8398917 MINT-8398737 MINT-8399014 MINT-8398779 MINT-8399000 MINT-8398937 MINT-8398816 MINT-8398862 MINT-8398799 MINT-8398846 MINT-8398755 TCF4 P15884 1 , 2 , 3 ENSP00000346440 4 EBI-491549,EBI-533224 MINT-8399030 MINT-8398882 MINT-8398896 MINT-8398917 MINT-4508268 MINT-8398937 MINT-8398969 MINT-8398862 MINT-4508065 I2D:
score=7 STRING: ENSP00000346440 TCF7L2 Q9NQB0 1 , 2 , 3 ENSP00000358404 4 EBI-491549,EBI-924724 MINT-1779698 MINT-7952386 MINT-2730974 MINT-7952375 I2D:
score=8 STRING: ENSP00000358404 AR P10275 1 , 2 , 3 ENSP00000363822 4 EBI-491549,EBI-608057 MINT-49803 MINT-49800 MINT-49801 MINT-49802 I2D:
score=5 STRING: ENSP00000363822
About this table Gene Ontology (GO): 5/161 biological process terms (GO ID links to tree view) (see all 161 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000122 negative regulation of transcription from RNA polymerase II promoter
IBA -- GO:0000578 embryonic axis specification
IBA -- GO:0000904 cell morphogenesis involved in differentiation
-- -- GO:0001501 skeletal system development
-- -- GO:0001569 patterning of blood vessels
IC --
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Drugs & Compoundsfor CTNNB1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for CTNNB1 available from Tocris Bioscience About this table Compound Action
CAS
# exo-IWR 1 Negative control for endo-IWR 1 (Cat. No. 3532) [1127442-87-8]
1 HMDB Compound for CTNNB1 About this table 1 DrugBank Compound for CTNNB1 About this table 10/145 Novoseek chemical compound relationships for CTNNB1 gene (see all 145 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
glycogen
83.9
399
18772141 (4), 10651115 (3), 15525634 (3), 9501208 (3) (see all 99 )
sb 415286
69
6
18602000 (1), 18687779 (1), 17234760 (1), 18190855 (1)
sb-216763
63.4
3
18474214 (1), 18602000 (1), 19795391 (1)
tyrosine
63.3
427
8707857 (6), 17851558 (5), 9233779 (5), 11710913 (5) (see all 99 )
crcs
62
11
14601048 (2), 15951972 (2), 18488710 (1), 19912361 (1) (see all 9 )
lithium chloride
61.5
22
18972237 (4), 18957842 (1), 16920823 (1), 17623674 (1) (see all 13 )
exisulind
60.4
25
12392815 (5), 20332437 (3), 11602670 (3), 10910034 (2) (see all 9 )
cp 461
51.1
2
12392815 (2)
samp
50.6
1
20197613 (1)
threonine
49.3
48
10076565 (2), 16849322 (2), 17996206 (2), 11351304 (1) (see all 36 )
CTNNB1 / CTNB1
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Transcriptsfor CTNNB1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CTNNB1 gene (3 alternative transcripts): NM_001098209.1 NM_001098210.1 NM_001904.3 Unigene Cluster for CTNNB1:
Catenin (cadherin-associated protein), beta 1, 88kDa Hs.476018 [show with all ESTs ] Unigene Representative Sequence: NM_001904 15 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000426215 ENST00000405570 (uc010hia.1 ) ENST00000433400 ENST00000431914 ENST00000396183 ENST00000349496 (uc003ckq.2 uc003ckp.2 uc003ckr.2 uc011azf.1 uc011azg.1 )ENST00000453024 ENST00000396185 ENST00000450969 ENST00000441708 ENST00000488914 ENST00000465552 ENST00000482042 (uc003ckt.1 ) ENST00000485265 ENST00000471014 Inhib. RNA EMD Millipore RNAi Products for the Analysis of CTNNB1 Gene knock-down OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat see all 7 )CTNNB1 CTNNB1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat
Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 7 )human mouse rat see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): CTNNB1 (NM_001904 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTNNB1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CTNNB1
Additional cDNA sequence: AB062292.1 AB451264.1 AB451392.1 AK289932.1 AK294778.1 AK296790.1 AK299954.1 AK314776.1 BC058926.1 U38440.1 X87838.1 Z19054.1
24/37 DOTS entries (see all 37 ): DT.92403676 DT.120851445
DT.95273403 DT.416816 DT.100790967 DT.100691212 DT.100790969 DT.97864234 DT.100758632 DT.86839981 DT.40122907 DT.95114382 DT.120851344 DT.75163896 DT.91766426 DT.100790963 DT.100059123 DT.448272 DT.95273402 DT.120851377 DT.120851393 DT.95273407 DT.120851381 DT.120851354 24/390 AceView cDNA sequences (see all 390 ):
BE763992 AW794781 CB151901 BX648430 BE172725 BP368185 AL045009 CR596976 AV708216 AU106947 AK095242 AI719357 AU077309 AA693599 AV657648 BX333007 AU121583 BX393661 AI365681 AA442092 BM550996 CD252394 AA652362 BQ213853 GeneLoc Exon Structure 5/14 Alternative Splicing Database (ASD) splice patterns (SP) for CTNNB1 (see all 14 ) About this scheme ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · SP1 : - - - - SP2 : - - - - SP3 : SP4 : - - - SP5 : - - - - - - - - -
ExUns: 15c · 15d ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c · 18d ^ 19 ^ 20 ^ 21a · 21b SP1 : - - - SP2 : - - - SP3 : - - - - SP4 : SP5 :
ECgene alternative splicing isoforms for CTNNB1
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Expression for CTNNB1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CTNNB1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTTTTGATCA
About this image CTNNB1 expression in embryonic tissues and stem cells About this table See CTNNB1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CTNNB1 SOURCE GeneReport for Unigene cluster: Hs.476018 UniProtKB/Swiss-Prot: CTNB1_HUMAN, P35222 Tissue specificity : Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of theouter and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level) SABiosciences Expression via Pathway-Focused PCR Arrays including CTNNB1 (see all 22 ): Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNB1
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Orthologsfor CTNNB1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for CTNNB1 gene from 7/23 species (see all 23 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Ctnnb11 5
catenin (cadherin associated protein), beta 11, 5
90.52(n) 1 99.87(a) 1
9 (72.19 cM) 5 12387 1 NM_001165902.1 1 NP_001159374.1 1 120929216 5
chicken Aves CTNNB11
catenin (cadherin-associated protein), beta 1, 88kDa
84.59(n) 99.36(a)
395964 NM_205081.1 NP_990412.1
lizard Reptilia CTNNB16
--
100(a)
1 ↔ 1
GL343224.1(884466-897742)
African clawed frog Amphibia ctnnb1-prov2
catenin
85.61(n)
BC045258.1
zebrafish Actinopterygii BC047815.12
--
78.72(n)
30265 BC047815.1
fruit fly Insecta arm1 3
frizzled receptor signaling pathwaymore 3 1
67(a) 3 64.27(n) 1 73.33(a) 1
1 2B143 31151 1 NM_206605.1 1 NP_996328.1 1
worm Secernentea hmp-21 3
Armadillo/beta-catenin-like repeats (43 1
34(a) 3 46.68(n) 1 37.34(a) 1
I(14747632-14750563)3 173338 1 NM_061165.4 1 NP_493566.1 1
ENSEMBL Gene Tree for CTNNB1 (if available)TreeFam Gene Tree for CTNNB1 (if available)
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Paralogsfor CTNNB1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CTNNB1 gene ARMC3 2 JUP 2 ARMC4 2 1 SIMAP similar gene for CTNNB1 using alignment to 9 protein entries: CTNB1_HUMAN (see all proteins ):JUP About GeneDecksing 2 Pseudogenes.org Pseudogenes for CTNNB1 PGOHUM00000235270 PGOHUM00000235646
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Genomic Variantsfor CTNNB1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 3 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for CTNNB1 (41236328 - 41301587 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CTNNB1: -- Human Gene Mutation Database (HGMD) : CTNNB1 5/55 SABiosciences Cancer Mutation PCR Assays for CTNNB1 (see all 55 ):
5/22 SABiosciences Cancer Mutation PCR Arrays containing CTNNB1 (see all 22 ):
2 SABiosciences qBiomarker Copy Number PCR Arrays containing CTNNB1 :
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor CTNNB1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 116806 OMIM disorders : 132600 167000 114550 UniProtKB/Swiss-Prot: CTNB1_HUMAN, P35222 Defects in CTNNB1 are associated with colorectal cancer (CRC) [MIM:114500] Note=Activating mutations in CTNNB1 have oncogenic activity resulting in tumor development. Somatic mutations are found in various tumor types, including colon cancers, ovarian and prostate carcinomas, hepatoblastoma (HB), hepatocellular carcinoma (HCC). HBs are malignant embryonal tumors mainly affecting young children in the first three years of life Defects in CTNNB1 are a cause of pilomatrixoma (PTR) [MIM:132600]; a common benign skin tumor Defects in CTNNB1 are a cause of medulloblastoma (MDB) [MIM:155255]. MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children Defects in CTNNB1 are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease Note=A chromosomal aberration involving CTNNB1 is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1 Defects in CTNNB1 may be a cause of mesothelioma malignant (MESOM) [MIM:156240]. An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos 20/256 (see all 256 ): About MalaCards adenomatous polyposis coli birt-hogg-dube syndrome polyposis pilomatrixoma dosage-sensitive sex reversal medulloblastoma townes-brocks syndrome peutz-jeghers syndrome ovarian cancer manic-depressive illness colorectal cancer atypical teratoid rhabdoid tumor familial adenomatous polyposis attenuated familial adenomatous polyposis primary pigmented nodular adrenocortical disease alveolar soft part sarcoma skeletal muscle regeneration sex reversal beckwith-wiedemann syndrome human t-cell leukemia virus type 1 6 diseases from the University of Copenhagen DISEASES database for CTNNB1 :Adenoma Familial adenomatous polyposis Medulloblastoma Colorectal cancer Nephroblastoma Carcinoma 10/95 Novoseek disease relationships for CTNNB1 gene (see all 95 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
familial adenomatous polyposis
93
454
8616874 (3), 10698523 (2), 10817505 (2), 11696170 (2) (see all 99 )
colon cancer
81.3
333
20514474 (6), 19190323 (5), 12810642 (5), 17030184 (5) (see all 99 )
colorectal cancer
79.9
333
11211307 (5), 16540637 (5), 18538736 (5), 16489032 (4) (see all 99 )
tumors
79.4
1681
15913427 (7), 17973813 (6), 16860348 (6), 15257551 (6) (see all 99 )
colorectal tumors
76.9
52
10359135 (2), 18992165 (2), 10197610 (2), 16091738 (2) (see all 33 )
cancer
76.7
651
12439747 (5), 15578921 (4), 19289465 (4), 19956499 (4) (see all 99 )
colorectal carcinoma
72.8
115
17927853 (5), 18949395 (3), 15785891 (3), 12912937 (3) (see all 72 )
microsatellite instability
72.8
73
17219201 (3), 15668893 (2), 15481028 (2), 17962810 (2) (see all 53 )
adenoma
72.6
246
12023580 (4), 10817505 (4), 12574842 (4), 10936679 (3) (see all 99 )
ovarian endometrioid adenocarcinoma
71.2
17
11719457 (2), 17418409 (2), 10417756 (2), 16452189 (1) (see all 10 )
Genetic Association Database (GAD): CTNNB1 Human Genome Epidemiology (HuGE) Navigator: CTNNB1 (66 documents) Export disorders for CTNNB1 gene to outside databases
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Publicationsfor CTNNB1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CTNNB1 gene, integrated from 9 sources (see all 3724 ):(articles sorted by number of sources associating them with CTNNB1) Utopia : connect your pdf to the dynamic
Beta-catenin expression in pilomatrixomas. Relationship with beta- catenin gene mutations and comparison with beta-catenin expression in normal hair follicles. (PubMed id 11703283) 1 , 2 , 9(2001) Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study. (PubMed id 16356174) 1 , 4, 9(2005) Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin. (PubMed id 12501215) 1 , 2 , 9(2002) Hot spots in beta-catenin for interactions with LEF-1, conductin and APC. (PubMed id 10966653) 1 , 2 , 9(2000) p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. (PubMed id 12640114) 1 , 2 , 9(2003) Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. (PubMed id 11389839) 1 , 2 , 9(2001) beta-Catenin is a Nek2 substrate involved in centrosome separation. (PubMed id 18086858) 1 , 2 , 9(2008) The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity. (PubMed id 18077326) 1 , 2 , 9(2007) Genotype phenotype correlations in Israeli colorectal cancer patients. (PubMed id 15523694) 1 , 4, 9(2005) Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas. (PubMed id 15520370) 1 , 4, 9(2004)
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External Searches for CTNNB1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CTNNB1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CTNNB1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CTNNB1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for CTNNB1 gene: CTNNB1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CTNNB1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for CTNNB1 OriGene shRNA RFP for CTNNB1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for CTNNB1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CTNNB1 OriGene 3'-UTR Clone for CTNNB1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for CTNNB1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CTNNB1 OriGene Custom Protein Services for CTNNB1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTNNB1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for CTNNB1
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNB1
ThermoFisher Antibody for CTNNB1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CTNNB1
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summary
for 
and Proteopedia 
for CTNNB1 (
PharmGKB Pathway for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Positive 
Microarrays
In-situ hybridization
