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CTNNAL1 Gene

protein-coding   GIFtS: 56
GCID: GC09M111704

Catenin (Cadherin-Associated Protein), Alpha-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Catenin (Cadherin-Associated Protein), Alpha-Like 11 2     Catenin Alpha-Like Protein 12 3
alpha-catulin1 2     ACRP2 3
alpha2-catulin1 2     CLLP2
Alpha-Catenin-Related Protein2 3     alpha-CATU2

External Ids:    HGNC: 25121   Entrez Gene: 87272   Ensembl: ENSG000001193267   OMIM: 6047855   UniProtKB: Q9UBT73   

Export aliases for CTNNAL1 gene to outside databases

Previous GC identifers: GC09M102503 GC09M103437 GC09M105162 GC09M107084 GC09M108784 GC09M110744 GC09M081304


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CTNNAL1 Gene:
CTNNAL1 (catenin (cadherin-associated protein), alpha-like 1) is a protein-coding gene. Diseases associated with CTNNAL1 include riley-day syndrome, and dysautonomia. GO annotations related to this gene include structural molecule activity and cadherin binding. An important paralog of this gene is CTNNA1.

UniProtKB/Swiss-Prot: CTNL1_HUMAN, Q9UBT7
Function: May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide
exchange factor (ARHGEF1)

Gene Wiki entry for CTNNAL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTNNAL1 gene promoter:
         c-Fos   AP-1   SREBP-1c   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   HNF-3beta   POU3F2   SREBP-1b   C/EBPalpha   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CTNNAL1 promoter sequence
   Search Chromatin IP Primers for CTNNAL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTNNAL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.2   Ensembl cytogenetic band:  9q31.3   HGNC cytogenetic band: 9q31.2

CTNNAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTNNAL1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M111704:  view genomic region     (about GC identifiers)

Start:
111,704,851 bp from pter      End:
111,775,809 bp from pter
Size:
70,959 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CTNL1_HUMAN, Q9UBT7 (See protein sequence)
Recommended Name: Alpha-catulin  
Size: 734 amino acids; 81896 Da
Subunit: Interacts with ARHGEF1
Secondary accessions: B5BU47 O76084 Q53FQ2 Q5JTQ7 Q5JTQ8 Q9Y401
Alternative splicing: 3 isoforms:  Q9UBT7-1   Q9UBT7-2   Q9UBT7-3   

Explore the universe of human proteins at neXtProt for CTNNAL1: NX_Q9UBT7

Explore proteomics data for CTNNAL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CTNNAL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273903.1  NP_003789.1  

    ENSEMBL proteins: 
     ENSP00000363723   ENSP00000320434   ENSP00000363722   ENSP00000363721   ENSP00000323351  

    CTNNAL1 Human Recombinant Protein Products:

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    Novus Biologicals CTNNAL1 Proteins
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    CTNNAL1 Antibody Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR006077 Vinculin/catenin
     IPR001033 Alpha_catenin

    Graphical View of Domain Structure for InterPro Entry Q9UBT7

    ProtoNet protein and cluster: Q9UBT7

    UniProtKB/Swiss-Prot: CTNL1_HUMAN, Q9UBT7
    Similarity: Belongs to the vinculin/alpha-catenin family


    CTNNAL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTNL1_HUMAN, Q9UBT7
    Function: May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide
    exchange factor (ARHGEF1)
    Induction: Down-regulated in cancer pancreatic cells undergoing differentiation and apoptosis

         Genatlas biochemistry entry for CTNNAL1:
    catenin alpha-catulin-like 1,cadherin-associated protein,widely expressed,including pancreas,heart and skeletal
    muscle,neural tissues,homolog to alpha-catenin and vinculin

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0045296cadherin binding IEA--
         
    CTNNAL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CTNNAL1:
     Increased cilium length after   Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTNNAL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTNNAL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTNNAL1

    miRNA
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    miRTarBase miRNAs that target CTNNAL1:
    hsa-mir-320a (MIRT044401)

    Block miRNA regulation of human, mouse, rat CTNNAL1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CTNNAL1:
    hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCTNNAL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CTNNAL1
    Predesigned siRNA for gene silencing in human, mouse, rat CTNNAL1

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    GenScript: all cDNA clones in your preferred vector: CTNNAL1 (NM_003798)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTNNAL1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNAL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTNL1_HUMAN, Q9UBT7: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    plasma membrane5
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA12270917
    GO:0005886plasma membrane IEA--
    GO:0015629actin cytoskeleton IEA--

    CTNNAL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTNNAL1
    Interactions:

        GeneGlobe Interaction Network for CTNNAL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for CTNNAL1 (Q9UBT73 ENSP000003204344) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKAP13Q128023, ENSP000003547184I2D: score=3 STRING: ENSP00000354718
    NEK1Q96PY63, ENSP000004080204I2D: score=4 STRING: ENSP00000408020
    ARHGEF1Q928883I2D: score=1 
    IKBKBO149203I2D: score=1 
    MTERFQ995513I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007266Rho protein signal transduction IDA12270917

    CTNNAL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTNNAL1 (CTNL1)

    3 HMDB Compounds for CTNNAL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CTNNAL1 gene (2 alternative transcripts): 
    NM_001286974.1  NM_003798.3  

    Unigene Cluster for CTNNAL1:

    Catenin (cadherin-associated protein), alpha-like 1
    Hs.58488  [show with all ESTs]
    Unigene Representative Sequence: AK123916
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374595(uc004bdp.1) ENST00000325551(uc010mts.1 uc004bdo.1)
    ENST00000374594 ENST00000488130 ENST00000374593 ENST00000325580
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CTNNAL1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CTNNAL1:
    hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCTNNAL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CTNNAL1
    Predesigned siRNA for gene silencing in human, mouse, rat CTNNAL1
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    GenScript: all cDNA clones in your preferred vector: CTNNAL1 (NM_003798)
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    OriGene qSTAR qPCR primer pairs in human, mouse for CTNNAL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTNNAL1
      QuantiTect SYBR Green Assays in human, mouse, rat CTNNAL1
      QuantiFast Probe-based Assays in human, mouse, rat CTNNAL1

    Additional mRNA sequence: 

    AB451283.1 AB451415.1 AF006070.1 AF030233.1 AF080071.1 AF135021.1 AK022539.1 AK022834.1 
    AK022926.1 AK123916.1 AK223230.1 AK314677.1 AL050016.1 BC117208.1 BC117234.1 U97067.1 

    16 DOTS entries:

    DT.116383  DT.99974493  DT.100817688  DT.92442361  DT.95091315  DT.95091325  DT.101967833  DT.208736 
    DT.448130  DT.101963734  DT.121189538  DT.208735  DT.95091319  DT.95124454  DT.121189463  DT.40250280 

    Selected AceView cDNA sequences (see all 260):

    BM460754 W80714 AA622751 BM976227 NM_003798 AI003722 BE552464 AA890256 
    AV701651 CR609649 AI042577 AI246358 BX952533 BM989793 BQ221755 AW627436 
    AI263453 AL545385 AV708266 BU675116 AU130251 AL545347 BU664923 BU677451 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CTNNAL1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
    SP1:                                                                                                  -                       -         
    SP2:                                                                                                  -                                 
    SP3:                                                                                                                                    


    ECgene alternative splicing isoforms for CTNNAL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTNNAL1 expression in normal human tissues (normalized intensities)      CTNNAL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACTGATTG
    CTNNAL1 Expression
    About this image


    CTNNAL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical Arteries
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Liver Bud
    CTNNAL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTNNAL1 Protein Expression

    Genevestigator expression for CTNNAL1

    SOURCE GeneReport for Unigene cluster: Hs.58488

    UniProtKB/Swiss-Prot: CTNL1_HUMAN, Q9UBT7
    Tissue specificity: Widely expressed. Expressed at lower level in neural tissues and at the highest level in the
    adrenal gland

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNAL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CTNNAL1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctnnal11 , 5 catenin (cadherin associated protein), alpha-like 11, 5 85.08(n)1
    87.97(a)1
      4 (31.66 cM)5
    543661  NM_018761.31  NP_061231.31 
     568109355 
    chicken
    (Gallus gallus)
    Aves CTNNAL11 catenin (cadherin-associated protein), alpha-like 1 76.1(n)
    77.38(a)
      100858912  XM_003640772.2  XP_003640820.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTNNAL16
    catenin (cadherin-associated protein), alpha-like ...
    68(a)
    1 ↔ 1
    4(67536822-67566540)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.115192 Xenopus laevis transcribed sequence with moderate similarity more 77.48(n)    BM262504.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ctnnal11 catenin (cadherin-associated protein), alpha-like 1 62.93(n)
    63.26(a)
      100034581  NM_001144054.1  NP_001137526.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alpha-catenin-related1 , 3 actin binding3
    alpha-catenin related1
    28(a)3
    44.15(n)1
    32.31(a)1
      60A143
    497131  NM_143816.31  NP_652073.21 
    worm
    (Caenorhabditis elegans)
    Secernentea ctn-11 , 3 ctn-11 38(a)3
    50.82(n)1
    41.88(a)1
      I(2606835-2617276)3
    1718181  NM_170829.41  NP_740813.21 


    ENSEMBL Gene Tree for CTNNAL1 (if available)
    TreeFam Gene Tree for CTNNAL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTNNAL1 gene
    CTNNA12  CTNNA22  CTNNA32  VCL2  

    CTNNAL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTNNAL1 (see all 1428)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828538951,2
    --111704421(+) CATACC/TCTCCA 1 -- ds50010--------
    rs1463904241,2
    --111704692(+) ATCTAA/GATGAT 1 -- ds50010--------
    rs1883251711,2
    --111704779(+) TGAGAC/TAGTTG 1 -- ds50010--------
    rs1443768851,2
    --111704785(+) AGTTGA/GGATAT 1 -- ds50010--------
    rs1465977401,2
    --111704813(+) GAACAA/TTAGTG 1 -- ds50010--------
    rs1121355141,2
    C--111704817(+) ATTAG-/TGCAAT 1 -- ds50011Minor allele frequency- T:0.00CSA 2
    rs283611841,2
    C--111704909(-) GATCAT/CGAAAC 1 -- ut313Minor allele frequency- C:0.01NS NA 178
    rs283611831,2
    C,F--111704974(-) TTTATC/GTTTTC 1 -- ut312Minor allele frequency- G:0.02NS WA 174
    rs2019712021,2
    C--111705030(+) CAGAGA/C/TTCTGA 2 -- ut310--------
    rs2015190441,2
    --111705061(+) TTACTA/CTCCAT 2 E D mis10--------

    HapMap Linkage Disequilibrium report for CTNNAL1 (111704851 - 111775809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CTNNAL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676852CNV Deletion23128226
    nsv6660CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604785    OMIM disorders: --

    11 diseases for CTNNAL1:    About MalaCards
    riley-day syndrome    dysautonomia    hellp syndrome    mucoepidermoid carcinoma
    narcolepsy    dilated cardiomyopathy    osteosarcoma    squamous cell carcinoma
    melanoma    pancreatitis    malaria


    CTNNAL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CTNNAL1
    Human Genome Epidemiology (HuGE) Navigator: CTNNAL1 (1 document)

    Export disorders for CTNNAL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTNNAL1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with CTNNAL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin. (PubMed id 9806841)1, 2, 3, 9 Zhang J.-S.... Smith D.I. (Genomics 1998)
    2. Association of Lbc Rho guanine nucleotide exchange factor with alpha- catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. (PubMed id 12270917)1, 2, 9 Park B.... Toksoz D. (J. Biol. Chem. 2002)
    3. Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing. (PubMed id 10542337)1, 2, 9 Janssens B.... van Roy F.M. (Biochim. Biophys. Acta 1999)
    4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Wound repair and proliferation of bronchial epithelial cells regulated by CTNNAL1. (PubMed id 17647259)1, 9 Xiang Y....Liu H.J. (J. Cell. Biochem. 2008)
    8. Distinct activities of the alpha-catenin family, alpha-catulin and alpha-catenin, on beta-catenin-mediated signaling. (PubMed id 14993280)1, 9 Merdek K.D....Toksoz D. (Mol. Cell. Biol. 2004)
    9. Alpha-catulin, a Rho signalling component, can regulate NF-kappaB through binding to IKK-beta, and confers resistance to apoptosis. (PubMed id 17952117)1, 9 Wiesner C....de Martin R. (Oncogene 2008)
    10. Alpha-catulin maps to the familial dysautonomia region on 9q31. (PubMed id 11768226)1, 9 Demacio P.C. and Ray P.N. (Genome 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8727 HGNC: 2512 AceView: CTNNAL1 Ensembl:ENSG00000119326 euGenes: HUgn8727
    ECgene: CTNNAL1 H-InvDB: CTNNAL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTNNAL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTNNAL1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ctnnal1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTNNAL1 gene:
    Search GeneIP for patents involving CTNNAL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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