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Aliases for CTNNAL1 Gene

Aliases for CTNNAL1 Gene

  • Catenin (Cadherin-Associated Protein), Alpha-Like 1 2 3
  • Alpha-Catenin-Related Protein 3 4
  • Catenin Alpha-Like Protein 1 3 4
  • Alpha2-Catulin 2 3
  • Alpha-Catulin 2 3
  • ACRP 3 4
  • Alpha-CATU 3
  • CLLP 3

External Ids for CTNNAL1 Gene

Summaries for CTNNAL1 Gene

GeneCards Summary for CTNNAL1 Gene

CTNNAL1 (Catenin (Cadherin-Associated Protein), Alpha-Like 1) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity and cadherin binding. An important paralog of this gene is CTNNA3.

UniProtKB/Swiss-Prot for CTNNAL1 Gene

  • May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1)

Gene Wiki entry for CTNNAL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTNNAL1 Gene

Genomics for CTNNAL1 Gene

Genomic Location for CTNNAL1 Gene

108,942,569 bp from pter
109,013,594 bp from pter
71,026 bases
Minus strand

Genomic View for CTNNAL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTNNAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTNNAL1 Gene

Proteins for CTNNAL1 Gene

  • Protein details for CTNNAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B5BU47
    • O76084
    • Q53FQ2
    • Q5JTQ7
    • Q5JTQ8
    • Q9Y401

    Protein attributes for CTNNAL1 Gene

    734 amino acids
    Molecular mass:
    81896 Da
    Quaternary structure:
    • Interacts with ARHGEF1.

    Alternative splice isoforms for CTNNAL1 Gene


neXtProt entry for CTNNAL1 Gene

Proteomics data for CTNNAL1 Gene at MOPED

Post-translational modifications for CTNNAL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTNNAL1 Gene

No data available for DME Specific Peptides for CTNNAL1 Gene

Domains for CTNNAL1 Gene

Protein Domains for CTNNAL1 Gene

Suggested Antigen Peptide Sequences for CTNNAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the vinculin/alpha-catenin family.:
    • Q9UBT7
genes like me logo Genes that share domains with CTNNAL1: view

No data available for Gene Families for CTNNAL1 Gene

Function for CTNNAL1 Gene

Molecular function for CTNNAL1 Gene

GENATLAS Biochemistry: catenin alpha-catulin-like 1,cadherin-associated protein,widely expressed,including pancreas,heart and skeletal muscle,neural tissues,homolog to alpha-catenin and vinculin
UniProtKB/Swiss-Prot Function: May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1)
UniProtKB/Swiss-Prot Induction: Down-regulated in cancer pancreatic cells undergoing differentiation and apoptosis.

Gene Ontology (GO) - Molecular Function for CTNNAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity --
GO:0005515 protein binding IPI 25416956
GO:0045296 cadherin binding IEA --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with CTNNAL1: view

Phenotypes for CTNNAL1 Gene

genes like me logo Genes that share phenotypes with CTNNAL1: view

miRNA for CTNNAL1 Gene

miRTarBase miRNAs that target CTNNAL1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CTNNAL1 Gene

Localization for CTNNAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTNNAL1 Gene

Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for CTNNAL1 Gene COMPARTMENTS Subcellular localization image for CTNNAL1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 5
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CTNNAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 12270917
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0015629 actin cytoskeleton --
genes like me logo Genes that share ontologies with CTNNAL1: view

Pathways for CTNNAL1 Gene

SuperPathways for CTNNAL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTNNAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007266 Rho protein signal transduction IDA 12270917
genes like me logo Genes that share ontologies with CTNNAL1: view

No data available for Pathways by source for CTNNAL1 Gene

Compounds for CTNNAL1 Gene

(3) HMDB Compounds for CTNNAL1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with CTNNAL1: view

Transcripts for CTNNAL1 Gene

Unigene Clusters for CTNNAL1 Gene

Catenin (cadherin-associated protein), alpha-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTNNAL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
SP1: - -
SP2: -

Relevant External Links for CTNNAL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTNNAL1 Gene

mRNA expression in normal human tissues for CTNNAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTNNAL1 Gene

This gene is overexpressed in Adrenal Gland (9.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTNNAL1 Gene

SOURCE GeneReport for Unigene cluster for CTNNAL1 Gene Hs.58488

mRNA Expression by UniProt/SwissProt for CTNNAL1 Gene

Tissue specificity: Widely expressed. Expressed at lower level in neural tissues and at the highest level in the adrenal gland.
genes like me logo Genes that share expressions with CTNNAL1: view

Orthologs for CTNNAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTNNAL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTNNAL1 35
  • 99.23 (n)
  • 99.32 (a)
  • 99 (a)
(Bos Taurus)
Mammalia CTNNAL1 35
  • 92.26 (n)
  • 92.64 (a)
  • 92 (a)
(Canis familiaris)
Mammalia CTNNAL1 35
  • 92.56 (n)
  • 93.37 (a)
  • 93 (a)
(Mus musculus)
Mammalia Ctnnal1 35
  • 85.08 (n)
  • 87.97 (a)
Ctnnal1 16
Ctnnal1 36
  • 88 (a)
(Monodelphis domestica)
Mammalia CTNNAL1 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia CTNNAL1 36
  • 66 (a)
(Rattus norvegicus)
Mammalia Ctnnal1 35
  • 85.01 (n)
  • 87.43 (a)
(Gallus gallus)
Aves CTNNAL1 35
  • 76.1 (n)
  • 77.38 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia CTNNAL1 36
  • 68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11519 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ctnnal1 35
  • 70.62 (n)
  • 72.07 (a)
(Danio rerio)
Actinopterygii ctnnal1 35
  • 62.93 (n)
  • 63.26 (a)
ctnnal1 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011097 35
  • 48.81 (n)
  • 41.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta alpha-catenin-related 35
  • 44.15 (n)
  • 32.31 (a)
alpha-catenin-related 36
  • 27 (a)
alpha-catenin-related 37
  • 28 (a)
(Caenorhabditis elegans)
Secernentea ctn-1 35
  • 50.82 (n)
  • 41.88 (a)
ctn-1 36
  • 35 (a)
ctn-1 37
  • 38 (a)
Species with no ortholog for CTNNAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTNNAL1 Gene

Gene Tree for CTNNAL1 (if available)
Gene Tree for CTNNAL1 (if available)

Paralogs for CTNNAL1 Gene

Paralogs for CTNNAL1 Gene

genes like me logo Genes that share paralogs with CTNNAL1: view

Variants for CTNNAL1 Gene

Sequence variations from dbSNP and Humsavar for CTNNAL1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs10152 -- 108,955,826(-) CGAGG(A/T)GAGAA reference, synonymous-codon
rs764201 -- 108,944,462(-) TCTGG(G/T)TATGG intron-variant
rs765427 -- 109,014,309(+) TTCTT(C/T)ATAAC upstream-variant-2KB
rs838816 -- 108,974,872(+) TTGAC(C/T)GTCTT intron-variant
rs838817 -- 108,970,936(+) TAACA(C/T)TGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTNNAL1 Gene

Variant ID Type Subtype PubMed ID
nsv6660 CNV Loss 18451855
esv2676852 CNV Deletion 23128226

Relevant External Links for CTNNAL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTNNAL1 Gene

Disorders for CTNNAL1 Gene

Relevant External Links for CTNNAL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CTNNAL1: view

No data available for UniProtKB/Swiss-Prot for CTNNAL1 Gene

Publications for CTNNAL1 Gene

  1. Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin. (PMID: 9806841) Zhang J.-S. … Smith D.I. (Genomics 1998) 2 3 4 23
  2. Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing. (PMID: 10542337) Janssens B. … van Roy F.M. (Biochim. Biophys. Acta 1999) 3 4 23
  3. Association of Lbc Rho guanine nucleotide exchange factor with alpha- catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. (PMID: 12270917) Park B. … Toksoz D. (J. Biol. Chem. 2002) 3 4 23
  4. Alpha-catulin maps to the familial dysautonomia region on 9q31. (PMID: 11768226) Demacio P.C. … Ray P.N. (Genome 2001) 3 23
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4

Products for CTNNAL1 Gene

  • antibodies-online proteins for CTNNAL1
  • antibodies-online antibodies for CTNNAL1
  • antibodies-online kits for CTNNAL1

Sources for CTNNAL1 Gene

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