Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CTNNAL1 Gene

Aliases for CTNNAL1 Gene

  • Catenin Alpha Like 1 2 3 5
  • Catenin (Cadherin-Associated Protein), Alpha-Like 1 2 3
  • Alpha-Catenin-Related Protein 3 4
  • Catenin Alpha-Like Protein 1 3 4
  • Alpha2-Catulin 2 3
  • Alpha-Catulin 2 3
  • ACRP 3 4
  • Catenin Alpha-Like 1 2
  • Alpha-CATU 3
  • CLLP 3

External Ids for CTNNAL1 Gene

Previous GeneCards Identifiers for CTNNAL1 Gene

  • GC09M102503
  • GC09M103437
  • GC09M105162
  • GC09M107084
  • GC09M108784
  • GC09M110744
  • GC09M111704
  • GC09M081304

Summaries for CTNNAL1 Gene

GeneCards Summary for CTNNAL1 Gene

CTNNAL1 (Catenin Alpha Like 1) is a Protein Coding gene. Among its related pathways are Toll-like Receptor Signaling Pathway. GO annotations related to this gene include structural molecule activity and cadherin binding. An important paralog of this gene is CTNNA2.

UniProtKB/Swiss-Prot for CTNNAL1 Gene

  • May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).

Gene Wiki entry for CTNNAL1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTNNAL1 Gene

Genomics for CTNNAL1 Gene

Regulatory Elements for CTNNAL1 Gene

Enhancers for CTNNAL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G109106 1.8 FANTOM5 Ensembl ENCODE dbSUPER 29.2 -90.8 -90812 5.6 PKNOX1 ATF1 ARNT FEZF1 ZNF48 TCF12 ZNF766 GATA2 CBX5 FOS CTNNAL1 FRRS1L ELP1 MIR32 ENSG00000199331 TMEM245 GC09M109081
GH09G109096 1.5 Ensembl ENCODE dbSUPER 34.9 -81.1 -81096 6.5 HDGF PKNOX1 FOXA2 ARNT ARID4B FEZF1 YY1 GATA2 FOS ZNF548 ELP1 CTNNAL1 FRRS1L TMEM245 FAM206A MIR32 ENSG00000199331 GC09M109081
GH09G109113 1.9 FANTOM5 Ensembl ENCODE dbSUPER 25 -98.7 -98704 9.0 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 FRRS1L ELP1 CTNNAL1 TMEM245 MIR32 ENSG00000199331 FAM206A GC09M109081
GH09G109128 1.4 ENCODE dbSUPER 32.3 -113.0 -113038 6.0 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 CTNNAL1 FRRS1L TMEM245 MIR32 ENSG00000199331 RNU6-984P EPB41L4B GC09M109131
GH09G109122 1.5 Ensembl ENCODE dbSUPER 23.1 -104.4 -104384 1.0 HDGF PKNOX1 ARNT ARID4B TCF12 ZNF766 GATA2 NCOA1 TSHZ1 ZNF592 CTNNAL1 ELP1 TMEM245 GC09M109131
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CTNNAL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CTNNAL1 Gene

Chromosome:
9
Start:
108,942,569 bp from pter
End:
109,018,802 bp from pter
Size:
76,234 bases
Orientation:
Minus strand

Genomic View for CTNNAL1 Gene

Genes around CTNNAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTNNAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTNNAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTNNAL1 Gene

Proteins for CTNNAL1 Gene

  • Protein details for CTNNAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBT7-CTNL1_HUMAN
    Recommended name:
    Alpha-catulin
    Protein Accession:
    Q9UBT7
    Secondary Accessions:
    • B5BU47
    • O76084
    • Q53FQ2
    • Q5JTQ7
    • Q5JTQ8
    • Q9Y401

    Protein attributes for CTNNAL1 Gene

    Size:
    734 amino acids
    Molecular mass:
    81896 Da
    Quaternary structure:
    • Interacts with ARHGEF1.

    Alternative splice isoforms for CTNNAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTNNAL1 Gene

Post-translational modifications for CTNNAL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTNNAL1 Gene

No data available for DME Specific Peptides for CTNNAL1 Gene

Domains & Families for CTNNAL1 Gene

Protein Domains for CTNNAL1 Gene

Suggested Antigen Peptide Sequences for CTNNAL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBT7

UniProtKB/Swiss-Prot:

CTNL1_HUMAN :
  • Belongs to the vinculin/alpha-catenin family.
Family:
  • Belongs to the vinculin/alpha-catenin family.
genes like me logo Genes that share domains with CTNNAL1: view

No data available for Gene Families for CTNNAL1 Gene

Function for CTNNAL1 Gene

Molecular function for CTNNAL1 Gene

GENATLAS Biochemistry:
catenin alpha-catulin-like 1,cadherin-associated protein,widely expressed,including pancreas,heart and skeletal muscle,neural tissues,homolog to alpha-catenin and vinculin
UniProtKB/Swiss-Prot Function:
May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
UniProtKB/Swiss-Prot Induction:
Down-regulated in cancer pancreatic cells undergoing differentiation and apoptosis.

Gene Ontology (GO) - Molecular Function for CTNNAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0045296 cadherin binding IEA --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with CTNNAL1: view
genes like me logo Genes that share phenotypes with CTNNAL1: view

Animal Model Products

CRISPR Products

miRNA for CTNNAL1 Gene

miRTarBase miRNAs that target CTNNAL1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTNNAL1 Gene

Localization for CTNNAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTNNAL1 Gene

Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTNNAL1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 4
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CTNNAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 12270917
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CTNNAL1: view

Pathways & Interactions for CTNNAL1 Gene

genes like me logo Genes that share pathways with CTNNAL1: view

Pathways by source for CTNNAL1 Gene

1 BioSystems pathway for CTNNAL1 Gene

Gene Ontology (GO) - Biological Process for CTNNAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007266 Rho protein signal transduction IEA,IDA 12270917
genes like me logo Genes that share ontologies with CTNNAL1: view

No data available for SIGNOR curated interactions for CTNNAL1 Gene

Drugs & Compounds for CTNNAL1 Gene

(3) Drugs for CTNNAL1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with CTNNAL1: view

Transcripts for CTNNAL1 Gene

Unigene Clusters for CTNNAL1 Gene

Catenin (cadherin-associated protein), alpha-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTNNAL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b
SP1: - -
SP2: -
SP3:

Relevant External Links for CTNNAL1 Gene

GeneLoc Exon Structure for
CTNNAL1
ECgene alternative splicing isoforms for
CTNNAL1

Expression for CTNNAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTNNAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTNNAL1 Gene

This gene is overexpressed in Adrenal Gland (x9.3).

Protein differential expression in normal tissues from HIPED for CTNNAL1 Gene

This gene is overexpressed in Bone (29.8) and Cerebrospinal fluid (25.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTNNAL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CTNNAL1 Gene:

CTNNAL1

SOURCE GeneReport for Unigene cluster for CTNNAL1 Gene:

Hs.58488

mRNA Expression by UniProt/SwissProt for CTNNAL1 Gene:

Q9UBT7-CTNL1_HUMAN
Tissue specificity: Widely expressed. Expressed at lower level in neural tissues and at the highest level in the adrenal gland.

Evidence on tissue expression from TISSUES for CTNNAL1 Gene

  • Nervous system(4.5)
  • Stomach(4.2)
  • Adrenal gland(2.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with CTNNAL1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTNNAL1 Gene

Orthologs for CTNNAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTNNAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTNNAL1 34 35
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia CTNNAL1 34 35
  • 92.56 (n)
cow
(Bos Taurus)
Mammalia CTNNAL1 34 35
  • 92.26 (n)
mouse
(Mus musculus)
Mammalia Ctnnal1 34 16 35
  • 85.08 (n)
rat
(Rattus norvegicus)
Mammalia Ctnnal1 34
  • 85.01 (n)
oppossum
(Monodelphis domestica)
Mammalia CTNNAL1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTNNAL1 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTNNAL1 34 35
  • 76.1 (n)
lizard
(Anolis carolinensis)
Reptilia CTNNAL1 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctnnal1 34
  • 70.62 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11519 34
zebrafish
(Danio rerio)
Actinopterygii ctnnal1 34 35
  • 62.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011097 34
  • 48.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta alpha-catenin-related 36 34 35
  • 44.15 (n)
worm
(Caenorhabditis elegans)
Secernentea ctn-1 36 34 35
  • 50.82 (n)
Species where no ortholog for CTNNAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTNNAL1 Gene

ENSEMBL:
Gene Tree for CTNNAL1 (if available)
TreeFam:
Gene Tree for CTNNAL1 (if available)

Paralogs for CTNNAL1 Gene

Paralogs for CTNNAL1 Gene

genes like me logo Genes that share paralogs with CTNNAL1: view

Variants for CTNNAL1 Gene

Sequence variations from dbSNP and Humsavar for CTNNAL1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000006986 -- 108,985,084(+) TAGAA(C/T)GTGTG intron-variant
rs1000012990 -- 108,975,330(+) AGGGG(C/T)AGGGG intron-variant
rs1000154177 -- 108,946,347(+) CATAT(A/T)TTACC intron-variant
rs1000204190 -- 108,944,264(+) CTCCA(A/G)TTATT intron-variant
rs1000208301 -- 108,985,386(+) TAGCC(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTNNAL1 Gene

Variant ID Type Subtype PubMed ID
esv2676852 CNV deletion 23128226
esv3621426 CNV loss 21293372
nsv1141020 CNV deletion 24896259
nsv475684 CNV novel sequence insertion 20440878
nsv6660 CNV deletion 18451855

Variation tolerance for CTNNAL1 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.59; 89.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTNNAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTNNAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTNNAL1 Gene

Disorders for CTNNAL1 Gene

Relevant External Links for CTNNAL1

Genetic Association Database (GAD)
CTNNAL1
Human Genome Epidemiology (HuGE) Navigator
CTNNAL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTNNAL1

No disorders were found for CTNNAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTNNAL1 Gene

Publications for CTNNAL1 Gene

  1. Identification and chromosomal localization of CTNNAL1, a novel protein homologous to alpha-catenin. (PMID: 9806841) Zhang J.-S. … Smith D.I. (Genomics 1998) 2 3 4 22 64
  2. Association of Lbc Rho guanine nucleotide exchange factor with alpha- catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. (PMID: 12270917) Park B. … Toksoz D. (J. Biol. Chem. 2002) 3 4 22 64
  3. Human alpha-catulin, a novel alpha-catenin-like molecule with conserved genomic structure, but deviating alternative splicing. (PMID: 10542337) Janssens B. … van Roy F.M. (Biochim. Biophys. Acta 1999) 3 4 22 64
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  5. Wound repair and proliferation of bronchial epithelial cells regulated by CTNNAL1. (PMID: 17647259) Xiang Y. … Liu H.J. (J. Cell. Biochem. 2008) 3 22 64

Products for CTNNAL1 Gene

Sources for CTNNAL1 Gene

Content
Loading form....