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Aliases & Descriptions for CTNNA3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases MGC26194 1 , 2 MGC75041 2 OTTHUMP00000019684 2 VR22 1 , 2 alpha-T-catenin 2
Descriptions Alpha T-catenin 3 Cadherin-associated protein 3 alpha-catenin-like protein 2 catenin (cadherin-associated protein), alpha 3 2 catenin, alpha 3 2
Search outside databases for aliases for CTNNA3 genePrevious GC identifers: GC00U990693 GC10M067024
Summaries for CTNNA3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: CTNA3_HUMAN, Q9UI47 Function : May be involved in formation of stretch-resistant cell-cell adhesion complexes
Genomic Location for CTNNA3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the CTNNA3 gene Entrez Gene cytogenetic band: 10q22.2 Ensembl cytogenetic band: 10q21.3 HGNC cytogenetic band: 10q21 CTNNA3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10M067349:
(about GC identifiers )
Start:
67,349,875 bp from pter
End:
69,125,933 bp from pter
Size:
1,776,059 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000010.9 NT_008583.16 Proteins for CTNNA3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: CTNA3_HUMAN, Q9UI47 (See
protein sequence )Recommended Name: Catenin alpha-3 Size : 895 amino acids; 99809 Da
Subunit : Interacts with CTNNB1
Subcellular location : Cytoplasm, cytoskeleton (Potential). Note=Localizes to intercalated disks ofcardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2
Secondary accessions : Q5VSR2 Q6P056Alternative splicing : 2 isoforms : Q9UI47-1 Q9UI47-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001120856.1 NP_037398.2 ENSEMBL proteins: ENSP00000330570 ENSP00000362840 ENSP00000362849 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for CTNNA3: Assays for CTNNA3:
Protein
Domains/ Families for CTNNA3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UI47 ProtoNet protein and cluster: Q9UI47
1 Blocks protein family : IPB001033 Alpha-catenin signature UniProtKB/Swiss-Prot: CTNA3_HUMAN, Q9UI47 Similarity : Belongs to the vinculin/alpha-catenin family
Gene Function for CTNNA3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Sigma-Aldrich , RNAi from
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Clones , and
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Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001127384 Applied Biosystems Silencer ® siRNAs for CTNNA3 Sigma-Aldrich siRNA for CTNNA3 Sigma-Aldrich shRNA Panels and shRNA for CTNNA3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001127384                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001127384                                  untagged cDNA clones in CMV expression vector (see all 3 ): BC022004  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_013266 UniProtKB/Swiss-Prot: CTNA3_HUMAN, Q9UI47 Function : May be involved in formation of stretch-resistant cell-cell adhesion complexes
3 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for CTNNA3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for CTNNA3 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for CTNNA3 5/20 Interacting proteins for CTNNA3 (ENSP00000362849 3 ) via UniProtKB, MINT, and/or STRING (see all 20
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
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Drugs & Compounds for CTNNA3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
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PharmGKB )
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Browse Tocris compounds for CTNNA3
Transcripts for CTNNA3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001127384 Sigma-Aldrich siRNA for CTNNA3 Sigma-Aldrich shRNA Panels and shRNA for CTNNA3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001127384 NM_013266
REFSEQ mRNAs for CTNNA3 gene (2 alternative transcripts): NM_001127384.1 NM_013266.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001127384 NM_013266
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001127384                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001127384                                  untagged cDNA clones in CMV expression vector (see all 3 ): BC022004  
Additional cDNA sequence: AF091606.1 AK289756.1 AK313882.1
7 DOTS entries : DT.91642243 DT.40221154 DT.100745832 DT.100745831 DT.40217936 DT.121212612 DT.97846537
22 AceView cDNA sequences :BQ717111 AY198183 BP362015 BC030646 BQ338136 BC065819 BP361310 BI549643 AW236052 BC022004 BI552791 BX494002 BQ338171 BQ338185 BG719928 BQ338153 BQ338186 AL589517 BQ338170 BQ338147 BQ338163 BQ338157
highest scoring ESTs for CTNNA3 :AA400832 AY198183 BG185990 BG187649 BG188061 BG189123 BG211334 BG211873 BG212447 BG213488
Unigene Clusters for CTNNA3: Catenin (cadherin-associated protein), alpha 3 Hs.660362 [show with all ESTs ] , Hs.692943 [show with all ESTs ] , Hs.715839 [show with all ESTs ] Unigene Representative Sequences: BC022004 , BC065819 , NM_013266 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations : ENST00000330298
ENST00000373735
ENST00000373744
Expression for CTNNA3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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CTNNA3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for CTNNA3 1 / 2 / 3
3 probe-sets matching CTNNA3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AGTGAATTTASOURCE GeneReport for Unigene clusters: Hs.660362 Hs.692943 Hs.715839 UniProtKB/Swiss-Prot: CTNA3_HUMAN, Q9UI47 Tissue specificity : Predominantly expressed in heart and testis. Expressed at lower levels inbrain, kidney, liver and skeletal muscle
Orthologs for CTNNA3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for CTNNA3 gene from 4 species
About this table Species with no ortholog for CTNNA3 ENSEMBL Gene Tree for CTNNA3 Paralogs for CTNNA3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for CTNNA3 gene CTNNA1 2 CTNNA2 2
SNPs/Variants for CTNNA3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for CTNNA3 (up to first 250kb)
Disorders & Mutations for CTNNA3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607667 1 Novoseek disease relationship for CTNNA3 gene
About this table Human Gene Mutation Database : CTNNA3 Genetic Association Database: CTNNA3 Human Genome Epidemiology Navigator: CTNNA3 (7 documents)
Medical News for CTNNA3 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for CTNNA3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/23 PubMed articles for CTNNA3 gene (see all 23
): Assessment of the CTNNA3 gene encoding human alpha T-catenin regarding its involvement in dilated cardiomyopathy. (PubMed id 12596047) 1, 2, 3, 4 Janssens B....Towbin J.A. (2003) alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion. (PubMed id 11590244) 2, 3, 4 Janssens B....van Roy F. (2001) Interaction between the alpha-T catenin gene (VR22) and APOE in Alzheimer's disease. (PubMed id 16199552) 1, 3, 6 Martin E.R....Pericak-Vance M.A. (2005) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054) 3, 4 Deloukas P.... Rogers J. (2004) Alpha-T-catenin (CTNNA3) displays tumour specific monoallelic expression in urothelial carcinoma of the bladder. (PubMed id 17366617) 1, 3 Meehan M....Mc Cann A. (2007) Differential downregulation of alphaT-catenin expression in placenta: trophoblast cell type-dependent imprinting of the CTNNA3 gene. (PubMed id 15533819) 1, 3 van Dijk M....Oudejans C. (2004) Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis. (PubMed id 19187332) 1, 3 Kim S.H....Park H.S. (2009) Is alpha-T catenin (VR22) an Alzheimer's disease risk gene? (PubMed id 17209133) 1, 3 Bertram L....Tanzi R.E. (2007)
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Genome Databases showing CTNNA3
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and/or
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Other Databases showing CTNNA3
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Specialized Databases showing CTNNA3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for CTNNA3 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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