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CTNNA3 Gene

protein-coding   GIFtS: 57

GC10M067349
catenin (cadherin-associated protein), alpha 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC26194 1, 2
MGC75041 2
OTTHUMP00000019684 2
VR22 1, 2
alpha-T-catenin 2
Descriptions
Alpha T-catenin 3
Cadherin-associated protein 3
alpha-catenin-like protein 2
catenin (cadherin-associated protein), alpha 3 2
catenin, alpha 3 2
External Ids
HGNC: 25111
Entrez Gene: 291192
UniProtKB: Q9UI473
Ensembl: ENSG000001832307
Search outside databases for aliases for CTNNA3 gene

Previous GC identifers: GC00U990693 GC10M067024

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: CTNA3_HUMAN, Q9UI47
Function: May be involved in formation of stretch-resistant cell-cell adhesion complexes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CTNNA3 gene  

Entrez Gene cytogenetic band: 10q22.2   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q21

CTNNA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M067349:     (about GC identifiers)

Start:
67,349,875 bp from pter
End:
69,125,933 bp from pter
Size:
1,776,059 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000010.9  NT_008583.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CTNA3_HUMAN, Q9UI47 (See protein sequence)
Recommended Name: Catenin alpha-3  
Size: 895 amino acids; 99809 Da
Subunit: Interacts with CTNNB1
Subcellular location: Cytoplasm, cytoskeleton (Potential). Note=Localizes to intercalated disks of
cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2
Secondary accessions: Q5VSR2 Q6P056
Alternative splicing: 2 isoforms:  Q9UI47-1   Q9UI47-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001120856.1  NP_037398.2  


    ENSEMBL proteins: 
    ENSP00000330570 ENSP00000362840 ENSP00000362849 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (CTNNA3, alpha T Catenin)
    Human Recombinant Proteins from Abnova (CTNNA3)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005916 fascia adherens IDA11590244
    GO:0015629 actin cytoskeleton IEA--
    GO:0030027 lamellipodium IEA--
    About this table

    Antibodies for CTNNA3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for CTNNA3
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (CTNNA3, alpha T Catenin), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (CTNNA3)
    Novus Biologicals Antibodies for CTNNA3

    Assays for CTNNA3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR006077 Vinculin/catenin
     IPR000633 Vinculin_CS
     IPR001033 Alpha_catenin


       GeneDecks  CTNNA3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UI47

    ProtoNet protein and cluster: Q9UI47

    1 Blocks protein family: IPB001033 Alpha-catenin signature

    UniProtKB/Swiss-Prot: CTNA3_HUMAN, Q9UI47
    Similarity: Belongs to the vinculin/alpha-catenin family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (CTNNA3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (CTNNA3)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001127384

                  Applied Biosystems Silencer® siRNAs for CTNNA3

                  Sigma-Aldrich siRNA for CTNNA3  
                         Sigma-Aldrich shRNA Panels and shRNA for CTNNA3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for CTNNA3
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001127384
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001127384
                                     untagged cDNA clones in CMV expression vector (see all 3): BC022004 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_013266

    UniProtKB/Swiss-Prot: CTNA3_HUMAN, Q9UI47
    Function: May be involved in formation of stretch-resistant cell-cell adhesion complexes

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198 structural molecule activity IEA--
    GO:0005515 protein binding IPI11590244
    GO:0045296 cadherin binding TAS11590244
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    2 Invitrogen iPath™ Online BioAtlas - Pathways for CTNNA3 (Maps provided by GeneGo):
     Cadherin-mediated cell adhesion
     Putative integrins pathway. Part 1

       GeneDecks  CTNNA3 for the pathways selected above  
    About GeneDecksing

    3 Millipore Pathways for CTNNA3
     Cell adhesion Endothelial cell contacts by junctional mechanisms
     Cell adhesion Cadherin-mediated cell adhesion
     Cell adhesion Endothelial cell contacts by non-junctional mechanisms

       GeneDecks  CTNNA3 for the pathways selected above  
    About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  CTNNA3  (Your Favorite Gene powered by Ingenuity) 
     Leukocyte Extravasation Signaling

       GeneDecks  CTNNA3 for the pathways selected above  
    About GeneDecksing

    5 Kegg Pathways  (Kegg details for CTNNA3):
     hsa04520 Adherens junction
     hsa04530 Tight junction
     hsa04670 Leukocyte transendothelial migration
     hsa05200 Pathways in cancer
     hsa05213 Endometrial cancer

       GeneDecks  CTNNA3 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  CTNNA3 


    5/20 Interacting proteins for CTNNA3 (ENSP000003628493) via UniProtKB, MINT, and/or STRING (see all 20 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTNNB1ENSP000003444563STRING (score=.991)
    CDH1ENSP000002687943STRING (score=.974)
    TJP1ENSP000002815373STRING (score=.947)
    TJP2ENSP000003664533STRING (score=.913)
    LRRTM3ENSP000003551873STRING (score=.887)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016337 cell-cell adhesion IPI11590244
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for CTNNA3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (CTNNA3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (CTNNA3)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001127384

                  Sigma-Aldrich siRNA for CTNNA3  
                         Sigma-Aldrich shRNA Panels and shRNA for CTNNA3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001127384  NM_013266  

    REFSEQ mRNAs for CTNNA3 gene (2 alternative transcripts): 

    NM_001127384.1   NM_013266.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001127384  NM_013266  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001127384
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001127384
                                     untagged cDNA clones in CMV expression vector (see all 3): BC022004 

    Additional cDNA sequence: 

    AF091606.1 AK289756.1 AK313882.1 

    7 DOTS entries:

    DT.91642243  DT.40221154  DT.100745832  DT.100745831  DT.40217936  DT.121212612  DT.97846537 

    22 AceView cDNA sequences:

    BQ717111 AY198183 BP362015 BC030646 BQ338136 BC065819 BP361310 BI549643 
    AW236052 BC022004 BI552791 BX494002 BQ338171 BQ338185 BG719928 BQ338153 
    BQ338186 AL589517 BQ338170 BQ338147 BQ338163 BQ338157 

    highest scoring ESTs for CTNNA3:

    AA400832 AY198183 BG185990 BG187649 BG188061 BG189123 BG211334 BG211873 BG212447 BG213488 

    Unigene Clusters for CTNNA3:

    Catenin (cadherin-associated protein), alpha 3
    Hs.660362  [show with all ESTs], Hs.692943  [show with all ESTs], Hs.715839  [show with all ESTs]
    Unigene Representative Sequences: BC022004, BC065819, NM_013266


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000330298  ENST00000373735  ENST00000373744  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    CTNNA3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for CTNNA3

    1 / 2 / 3

    3 probe-sets matching CTNNA3 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    220815_at2, 3 U133-A 1 1.00 1.00 -- -- NM_013266 0.60 1.00 0.82 1

    220815_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554235_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AGTGAATTTA

    SOURCE GeneReport for Unigene clusters: Hs.660362 Hs.692943 Hs.715839

    UniProtKB/Swiss-Prot: CTNA3_HUMAN, Q9UI47
    Tissue specificity: Predominantly expressed in heart and testis. Expressed at lower levels in
    brain, kidney, liver and skeletal muscle

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for CTNNA3 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    CTNNA31   -- catenin (cadherin-associated protein), alpha 3 92.7(n)
    95.75(a)
    489008  XM_854268.1  XP_859361.1 
    chimpanzee
    (Pan troglodytes)
    CTNNA31   -- catenin (cadherin-associated protein), alpha 3 99.55(n)
    99.44(a)
    746091  XM_001167099.1  XP_001167099.1 
    mouse
    (Mus musculus)
    Ctnna31, 5 105
    catenin (cadherin associated protein), alpha 31, 5 87.11(n)1
    93.18(a)1
    2160331  NM_177612.21  NP_808280.11 
     AF3448715  AK0152415  (see all 13)
    chicken
    (Gallus gallus)
    CTNNA31   -- catenin (cadherin-associated protein), alpha 3 78.24(n)
    83.87(a)
    423648  XM_001232672.1  XP_001232673.1 
    About this table        Species with no ortholog for CTNNA3

    ENSEMBL Gene Tree for CTNNA3
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for CTNNA3 gene
    CTNNA12  CTNNA22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/10295 NCBI SNPs in CTNNA3 are shown (see all 10295 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 3637)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs45485131,2
    A,C,F,H67710331(+) ATGAGC/TTTTTG 2 S/N mis112Minor allele frequency- N:0.00EU EA WA NA 1054
    rs109977841,2
    C,F,H69127008(+) TATCCT/GCCCCA 1 -- ng318Minor allele frequency- G:0.12EU EA WA 832
    rs19419961,2
    C,F,H67349574(-) AAAAAC/ACACCT 1 -- ng5112Minor allele frequency- A:0.12NS NA EU EA WA 652
    rs118120941,2
    C,H69127562(+) TAGTAT/CTTAGC 1 -- ng314Minor allele frequency- C:0.00EU EA WA 416
    rs109977541,2
    C,H69036702(+) CTTGTC/GTAATA 2 D/H mis1 ese34Minor allele frequency- G:0.00EU EA WA 418
    rs109970341,2
    C,F,H67710246(+) ATCATG/TACTGA 2 V/V syn14Minor allele frequency- T:0.04EU EA WA 412
    rs26209151,2
    A,C,F,H,O68749812(+) TGTGAT/CGGCAT 1 -- int116Minor allele frequency- C:0.42NS EU EA WA NA 1074
    rs26167001,2
    A,C,F,H,O68763092(-) TTGGCC/TTGTTG 1 -- int17Minor allele frequency- T:0.30EU EA WA NA 560
    rs29399461,2
    A,C,F,H,O67807973(+) AAATTT/AAAAAA 1 -- int111Minor allele frequency- A:0.41NA EU EA WA 976
    rs23942751,2
    A,C,F,H,O68088305(+) ACATAT/ATTTTG 1 -- int115Minor allele frequency- A:0.08EU EA WA NA 1398
    About this table

    HapMap Linkage Disequilibrium images for CTNNA3 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 607667

    1 Novoseek disease relationship for CTNNA3 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 48.98 17 16199552 (4), 17209133 (4), 16327352 (1), 15039120 (1) (see all 5)
    About this table

    Human Gene Mutation Database: CTNNA3
    Genetic Association Database: CTNNA3
    Human Genome Epidemiology Navigator: CTNNA3 (7 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/23 PubMed articles for CTNNA3 gene (see all 23 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 29119 HGNC: 2511 AceView: CTNNA3.1 Ensembl:ENSG00000183230 euGenes: HUgn29119
    ECgene: CTNNA3 H-InvDB: CTNNA3
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for CTNNA3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for CTNNA3 Antibodies for CTNNA3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for CTNNA3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
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     Search OriGene for CTNNA3
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for CTNNA3

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