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Aliases for CTNNA2 Gene

Aliases for CTNNA2 Gene

  • Catenin (Cadherin-Associated Protein), Alpha 2 2 3
  • CAPR 3 4 6
  • Alpha-Catenin-Related Protein 3 4
  • Cancer/Testis Antigen 114 2 3
  • Alpha N-Catenin 3 4
  • CTNR 3 6
  • Cadherin-Associated Protein, Related 3
  • Cadherin-Associated Protein 2
  • Catenin Alpha-2 3
  • Alpha-N-Catenin 3
  • Related 2
  • CAP-R 3
  • CT114 3

External Ids for CTNNA2 Gene

Previous GeneCards Identifiers for CTNNA2 Gene

  • GC02P080016
  • GC02P079697
  • GC02P079853
  • GC02P079790
  • GC02P079593
  • GC02P079412

Summaries for CTNNA2 Gene

GeneCards Summary for CTNNA2 Gene

CTNNA2 (Catenin (Cadherin-Associated Protein), Alpha 2) is a Protein Coding gene. Diseases associated with CTNNA2 include benign schwannoma. Among its related pathways are Pathways in cancer and L1CAM interactions. GO annotations related to this gene include structural constituent of cytoskeleton and cadherin binding. An important paralog of this gene is CTNNA3.

UniProtKB/Swiss-Prot for CTNNA2 Gene

  • May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTNNA2 Gene

Genomics for CTNNA2 Gene

Regulatory Elements for CTNNA2 Gene

Genomic Location for CTNNA2 Gene

Start:
79,185,231 bp from pter
End:
80,648,868 bp from pter
Size:
1,463,638 bases
Orientation:
Plus strand

Genomic View for CTNNA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTNNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTNNA2 Gene

Proteins for CTNNA2 Gene

  • Protein details for CTNNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26232-CTNA2_HUMAN
    Recommended name:
    Catenin alpha-2
    Protein Accession:
    P26232
    Secondary Accessions:
    • B3KXE5
    • B7Z2W7
    • B7Z352
    • B7Z898
    • Q4ZFW1
    • Q53R26
    • Q53R33
    • Q53T67
    • Q53T71
    • Q53TM8
    • Q7Z3L1
    • Q7Z3Y0

    Protein attributes for CTNNA2 Gene

    Size:
    953 amino acids
    Molecular mass:
    105313 Da
    Quaternary structure:
    • Interacts with ZNF639.

    Alternative splice isoforms for CTNNA2 Gene

neXtProt entry for CTNNA2 Gene

Proteomics data for CTNNA2 Gene at MOPED

Post-translational modifications for CTNNA2 Gene

  • Ubiquitination at Lys15
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CTNNA2 (CTNNA2)

No data available for DME Specific Peptides for CTNNA2 Gene

Domains for CTNNA2 Gene

Protein Domains for CTNNA2 Gene

Suggested Antigen Peptide Sequences for CTNNA2 Gene

Graphical View of Domain Structure for InterPro Entry

P26232

UniProtKB/Swiss-Prot:

CTNA2_HUMAN :
  • P26232
Family:
  • Belongs to the vinculin/alpha-catenin family.
genes like me logo Genes that share domains with CTNNA2: view

No data available for Gene Families for CTNNA2 Gene

Function for CTNNA2 Gene

Molecular function for CTNNA2 Gene

GENATLAS Biochemistry:
catenin alpha 2,102 kDa,desmosomal plaque component,regulating cell adhesion (component of the E cadherin multiprotein complex,homologous to vinculin)
UniProtKB/Swiss-Prot Function:
May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).

Gene Ontology (GO) - Molecular Function for CTNNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity --
GO:0005200 structural constituent of cytoskeleton NAS 8432524
GO:0005515 protein binding IPI 16182284
GO:0045296 cadherin binding IEA --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with CTNNA2: view
genes like me logo Genes that share phenotypes with CTNNA2: view

Animal Models for CTNNA2 Gene

MGI Knock Outs for CTNNA2:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTNNA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CTNNA2 Gene

Localization for CTNNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTNNA2 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Note=Recruited to the nucleus upon ZNF639 overexpression.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTNNA2 Gene COMPARTMENTS Subcellular localization image for CTNNA2 gene
Compartment Confidence
plasma membrane 5
cytosol 4
cytoskeleton 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for CTNNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16182284
GO:0005829 cytosol TAS --
GO:0005912 adherens junction ISS --
GO:0005913 cell-cell adherens junction IEA --
GO:0015629 actin cytoskeleton IEA --
genes like me logo Genes that share ontologies with CTNNA2: view

Pathways for CTNNA2 Gene

genes like me logo Genes that share pathways with CTNNA2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CTNNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion --
GO:0007409 axonogenesis ISS --
GO:0016337 single organismal cell-cell adhesion ISS --
GO:0021942 radial glia guided migration of Purkinje cell ISS --
GO:0042692 muscle cell differentiation TAS --
genes like me logo Genes that share ontologies with CTNNA2: view

Transcripts for CTNNA2 Gene

Unigene Clusters for CTNNA2 Gene

Catenin (cadherin-associated protein), alpha 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTNNA2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTNNA2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - -
SP2: - - -
SP3: - - - - - -
SP4: - -
SP5: -

Relevant External Links for CTNNA2 Gene

GeneLoc Exon Structure for
CTNNA2
ECgene alternative splicing isoforms for
CTNNA2

Expression for CTNNA2 Gene

mRNA expression in normal human tissues for CTNNA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTNNA2 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (7.0), Brain - Amygdala (6.8), Brain - Cortex (6.5), Brain - Anterior cingulate cortex (BA24) (6.3), Brain - Hippocampus (4.9), and Brain - Caudate (basal ganglia) (4.4).

Protein differential expression in normal tissues for CTNNA2 Gene

This gene is overexpressed in Fetal Brain (13.9), Brain (13.8), Retina (9.4), and Frontal cortex (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTNNA2 Gene

SOURCE GeneReport for Unigene cluster for CTNNA2 Gene Hs.167368

genes like me logo Genes that share expressions with CTNNA2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for CTNNA2 Gene

Orthologs for CTNNA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTNNA2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CTNNA2 35
  • 94.26 (n)
  • 99.58 (a)
CTNNA2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctnna2 35
  • 90.77 (n)
  • 99.9 (a)
Ctnna2 16
Ctnna2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTNNA2 35
  • 99.23 (n)
  • 99.88 (a)
rat
(Rattus norvegicus)
Mammalia Ctnna2 35
  • 90.98 (n)
  • 99.9 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 99 (a)
OneToMany
CTNNA2 36
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CTNNA2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTNNA2 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTNNA2 35
  • 83.06 (n)
  • 99.34 (a)
-- 36
  • 97 (a)
OneToMany
CTNNA2 36
  • 100 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 100 (a)
OneToMany
-- 36
  • 88 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ctnna2 35
  • 81.6 (n)
  • 96.01 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6961 35
zebrafish
(Danio rerio)
Actinopterygii ctnna2 35
  • 80.12 (n)
  • 96.07 (a)
ctnna2 36
  • 96 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta alpha-Cat 37
  • 60 (a)
alpha-Cat 35
  • 62.23 (n)
  • 65.69 (a)
alpha-Cat 36
  • 63 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003424 35
  • 63.2 (n)
  • 65.99 (a)
worm
(Caenorhabditis elegans)
Secernentea hmp-1 37
  • 37 (a)
hmp-1 35
  • 48.42 (n)
  • 41.55 (a)
hmp-1 36
  • 39 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3973 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToOne
Species with no ortholog for CTNNA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTNNA2 Gene

ENSEMBL:
Gene Tree for CTNNA2 (if available)
TreeFam:
Gene Tree for CTNNA2 (if available)

Paralogs for CTNNA2 Gene

Paralogs for CTNNA2 Gene

Selected SIMAP similar genes for CTNNA2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CTNNA2: view

Variants for CTNNA2 Gene

Sequence variations from dbSNP and Humsavar for CTNNA2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs367287 -- 80,279,019(+) TTTGG(A/G/T)TTTGT intron-variant
rs648361 -- 79,977,203(+) ACACA(A/C/T)GTGCA intron-variant
rs1484469 -- 80,025,091(+) TCTCC(A/G/T)ACATC intron-variant
rs1816455 -- 80,559,260(+) ATTAC(A/G/T)AAGAA intron-variant
rs1899903 -- 80,426,298(+) ATTTG(A/G/T)GTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTNNA2 Gene

Variant ID Type Subtype PubMed ID
nsv522260 CNV Gain 19592680
esv2720256 CNV Deletion 23290073
nsv458407 CNV Loss 19166990
nsv874375 CNV Loss 21882294
esv2675267 CNV Deletion 23128226
nsv874376 CNV Loss 21882294
nsv433201 CNV Loss 18776910
nsv518912 CNV Loss 19592680
nsv527416 CNV Gain 19592680
esv2720257 CNV Deletion 23290073
esv2720258 CNV Deletion 23290073
nsv829480 CNV Gain 20364138
nsv528724 CNV Loss 19592680
nsv2800 CNV Insertion 18451855
esv274326 CNV Insertion 20981092
nsv528619 CNV Loss 19592680
esv34179 CNV Loss 18971310
nsv874377 CNV Loss 21882294
nsv2801 CNV Insertion 18451855
esv272699 CNV Insertion 20981092
esv27488 CNV Loss 19812545
nsv874378 CNV Gain 21882294
nsv516404 CNV Gain 19592680
nsv524592 CNV Gain 19592680
nsv437287 CNV Loss 16327808
esv2672919 CNV Deletion 23128226
nsv458418 CNV Loss 19166990
nsv874379 CNV Loss 21882294
dgv1208e1 CNV Complex 17122850
dgv1209e1 CNV Complex 17122850
esv2663198 CNV Deletion 23128226
nsv516819 CNV Loss 19592680
esv6333 CNV Gain 19470904
nsv528317 CNV Loss 19592680
dgv1210e1 CNV Complex 17122850
essv7177 CNV CNV 17122850
esv2720259 CNV Deletion 23290073
dgv466n27 CNV Loss 19166990
esv269813 CNV Insertion 20981092
esv2658492 CNV Deletion 23128226
nsv874380 CNV Loss 21882294
nsv818061 CNV Gain 17921354
nsv10054 CNV Loss 18304495
nsv829482 CNV Loss 20364138
esv272281 CNV Insertion 20981092
esv268628 CNV Insertion 20981092
nsv10055 CNV Gain 18304495
nsv10056 CNV Loss 18304495
esv22845 CNV Loss 19812545
esv270971 CNV Insertion 20981092

Relevant External Links for CTNNA2 Gene

HapMap Linkage Disequilibrium report
CTNNA2
Human Gene Mutation Database (HGMD)
CTNNA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTNNA2 Gene

Disorders for CTNNA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CTNNA2 Gene in MalaCards »

(1) Diseases for CTNNA2 Gene including...

Relevant External Links for CTNNA2

Genetic Association Database (GAD)
CTNNA2
Human Genome Epidemiology (HuGE) Navigator
CTNNA2
genes like me logo Genes that share disorders with CTNNA2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CTNNA2 Gene

Publications for CTNNA2 Gene

  1. Characterization and chromosomal assignment of a human cDNA encoding a protein related to the murine 102-kDa cadherin-associated protein (alpha-catenin). (PMID: 8432524) Claverie J.-M. … Petit C. (Genomics 1993) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Nuclear translocation of alphaN-catenin by the novel zinc finger transcriptional repressor ZASC1. (PMID: 16182284) Bogaerts S. … van Roy F. (Exp. Cell Res. 2005) 3 4
  5. Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization. (PMID: 1638632) Hirano S. … Takeichi M. (Cell 1992) 3 23

Products for CTNNA2 Gene

Sources for CTNNA2 Gene

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