CTNNA1 Gene
protein-coding GIFtS: 63
GCID: GC05P137947
|
|
catenin (cadherin-associated protein), alpha 1, 102kDa(Previous names: catenin (cadherin-associated protein), alpha 1 (102kD)...)
| |
Aliases
for CTNNA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Catenin (Cadherin-Associated Protein), Alpha 1, 102kDa1 2 | | Alpha-Catenin1 | | CAP1021 2 | | AlphaE-Catenin1 | | Alpha E-Catenin2 3 | | Cadherin-Associated Protein,102kDa2 | | Renal Carcinoma Antigen NY-REN-132 3 | | Catenin Alpha-12 | | Catenin (Cadherin-Associated Protein), Alpha 1 (102kD)1 | | Cadherin-Associated Protein3 | | Alpha-E-Catenin1 | | |
Export aliases for CTNNA1 gene to outside databasesPrevious GC identifers: GC05P137992 GC05P138765 GC05P138119 GC05P138165 GC05P138193 GC05P138117 GC05P133278 |
Summaries
for CTNNA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221Function: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherinsproduces a complex which is linked to the actin filament network, and which seems to be of primary importance forcadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stablecomponent of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeletonat adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexesand CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actinand adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actinbranching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in celldifferentiation
Gene Wiki entry for CTNNA1 (Catenin, alpha 1)
|
Genomic Views
for CTNNA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CTNNA1 gene promoter:
HOXA9B HOXA9 GR POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) IRF-1 POU3F2 GR-alpha Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CTNNA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTNNA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.2 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31.2CTNNA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P137947: view genomic region
(about GC identifiers)
Start:
|
137,946,656 bp from pter |
End:
|
138,270,723 bp from pter |
Size:
|
324,068 bases |
Orientation:
|
plus strand |
|
Proteins
for CTNNA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221 (See
protein sequence)Recommended Name: Catenin alpha-1 Size: 906 amino acids; 100071 Da
Subunit: Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin. Binds MLLT4 andF-actin. Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 andbeta-catenin/CTNNB1 or gamma-catenin/JUP; the complex is located to adherens junctions. The stable association ofCTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, theCTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Interacts with ARHGAP21 and withAJUBA. Interacts with LIMA1 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membraneprotein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries
3 PDB 3D structures from  and Proteopedia  for CTNNA1:1H6G (3D)
4EHP (3D)
4IGG (3D)
Secondary accessions: Q12795Alternative splicing: 2 isoforms: P35221-1 P35221-2 Explore the universe of human proteins at neXtProt for CTNNA1: NX_P35221
Post-translational modifications:
Sumoylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P35221
CTNNA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001894.2
ENSEMBL proteins: ENSP00000428439 ENSP00000429636 ENSP00000428049 ENSP00000430304 ENSP00000428202 ENSP00000431033 ENSP00000304669 ENSP00000430626 ENSP00000430671 ENSP00000428457 ENSP00000430078 ENSP00000429457 ENSP00000427821 ENSP00000429142 ENSP00000429738 ENSP00000430379 ENSP00000429569 ENSP00000428044 ENSP00000430841 ENSP00000428088 ENSP00000431118 ENSP00000430240 ENSP00000429103 ENSP00000430177 ENSP00000430981 ENSP00000430623 ENSP00000428894 ENSP00000428710 ENSP00000428686 ENSP00000430076 ENSP00000347190 ENSP00000438476 Reactome Protein details: P35221
Human Recombinant Protein Products:
Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table
CTNNA1 for ontologies About GeneDecksing
CTNNA1 Antibody Products:
Assay Products for CTNNA1: |
Protein
Domains /
Families
for CTNNA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CTNNA1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P35221ProtoNet protein and cluster: P35221 1 Blocks protein family: IPB001033 Alpha-catenin signature
UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221Similarity: Belongs to the vinculin/alpha-catenin family |
Function
for CTNNA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221Function: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherinsproduces a complex which is linked to the actin filament network, and which seems to be of primary importance forcadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stablecomponent of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeletonat adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexesand CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actinand adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actinbranching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in celldifferentiation Genatlas biochemistry entry for CTNNA1:catenin alpha 1,102kDa,desmosomal plaque component,regulating cell adhesion (component of the E cadherin multiproteincomplex
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTNNA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTNNA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CTNNA1 (NM_001903) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTNNA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTNNA1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNA1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
CTNNA1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for CTNNA1:
Animal Models:
12 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ctnna1):
CTNNA1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CTNNA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of p38 alpha/beta MAPK | | | 2 | Cell-cell junction organization | | | 3 | Sertoli-Sertoli Cell Junction Dynamics | | | 4 | Cell adhesion Endothelial cell contacts by junctional mechanisms | | | 5 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for CTNNA1
5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CTNNA1 (see all 10)
1 
Cell Signaling Technology (CST) Pathway for CTNNA1
3  GeneGo (Thomson Reuters) Pathways for CTNNA1
5/10  BioSystems Pathways for CTNNA1 (see all 10)
5/9 
Reactome Pathways for CTNNA1 (see all 9)
5/7 
Kegg Pathways (Kegg details for CTNNA1) (see all 7):
CTNNA1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTNNA1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/141 Interacting proteins for CTNNA1 (P352212, 3 ENSP000003046694) via UniProtKB, MINT, STRING, and/or I2D (see all 141)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| PARD3 | Q8TEW02, 3, ENSP000003639214 | MINT-4085250 I2D:
score=1 STRING: ENSP00000363921 | | CTNNB1 | P352222, 3, ENSP000003444564 | MINT-7010191 MINT-46006 I2D:
score=9 STRING: ENSP00000344456 | | CDH1 | P128302, 3, ENSP000002617694 | MINT-7010191 I2D:
score=6 STRING: ENSP00000261769 | | CDH5 | P331512, 3, ENSP000003441154 | MINT-4085212 I2D:
score=2 STRING: ENSP00000344115 | | CTBP1 | Q133632, 3, ENSP000002909214 | MINT-8253858 I2D:
score=2 STRING: ENSP00000290921 |
About this table
Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001541 | ovarian follicle development |
IEA | -- | | GO:0007155 | cell adhesion |
IEA | -- | | GO:0007163 | establishment or maintenance of cell polarity |
IEA | -- | | GO:0007406 | negative regulation of neuroblast proliferation |
IEA | -- | | GO:0007568 | aging |
IEA | -- |
CTNNA1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CTNNA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CTNNA1 for compounds About GeneDecksing
 Browse Tocris compounds for CTNNA1
10/15 Novoseek chemical compound relationships for CTNNA1 gene (see all 15) About this table
Search CenterWatch for drugs/clinical trials and news about CTNNA1 / CTNA1
|
Transcripts
for CTNNA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CTNNA1 gene: NM_001903.2 Unigene Clusters for CTNNA1: Catenin (cadherin-associated protein), alpha 1, 102kDa Hs.445981 [show with all ESTs], Hs.656653 [show with all ESTs]Unigene Representative Sequences: NM_001903, NM_01556418/45 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 45): ENST00000517980 ENST00000522227 ENST00000524127 ENST00000523912 ENST00000520339
ENST00000521724 ENST00000302763(uc003ldh.3 uc011cyx.2 uc011cyy.2 uc003ldi.3 uc003ldj.3)
ENST00000518910 ENST00000521941 ENST00000519309 ENST00000518245 ENST00000519113
ENST00000520158 ENST00000518825 ENST00000518585 ENST00000518919 ENST00000523275
ENST00000522730
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTNNA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTNNA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CTNNA1 (NM_001903) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTNNA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTNNA1 |
Additional cDNA sequence: AB007876.1 AK291064.1 AK297332.1 AK309790.1 AY182026.1 BC126408.1 BC126410.1 BC143926.1 24/81 DOTS entries (see all 81): DT.100039653 DT.411950 DT.92465907 DT.100877550 DT.97860742 DT.95099198 DT.95099213 DT.100877566 DT.100877563 DT.100877557 DT.40116642 DT.100698423 DT.95099210 DT.100803613 DT.120805841 DT.120805769 DT.95213446 DT.100647294 DT.120805830 DT.100877547 DT.454141 DT.97793731 DT.120805739 DT.92465923 24/699 AceView cDNA sequences (see all 699): AA677769 AI858805 AA843133 BU838528 BU838897 BM975341 BQ064744 AA331026 BQ887572 AU132270 BM801338 AU133743 BQ925358 BQ279078 BE713195 BM791816 BM791628 AA356359 BQ232424 CA392351 AW029204 AU131234 CD515590 D13866
GeneLoc Exon Structure
5/18 Alternative Splicing Database (ASD) splice patterns (SP) for CTNNA1 (see all 18) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | - | | | | - | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
| ExUns: | 15b | ^ | 16 | ^ | 17a | · | 17b | · | 17c | · | 17d | · | 17e | · | 17f | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25a | · | 25b | ^ | 26a | · | 26b | · | 26c |
|---|
|
| SP1: | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP2: | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CTNNA1
|
Expression
for CTNNA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CTNNA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATGAAAAT
About this image
See CTNNA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTNNA1
SOURCE GeneReport for Unigene clusters: Hs.445981 Hs.656653
UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221Tissue specificity: Expressed ubiquitously in normal tissues
SABiosciences Expression via Pathway-Focused PCR Arrays including CTNNA1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTNNA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTNNA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTNNA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTNNA1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNA1 |
Orthologs
for CTNNA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CTNNA1 gene from 7/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ctnna11 , 5 |
catenin (cadherin associated protein), alpha 11, 5 |
91.83(n)1
99.45(a)1 |
|
18 (18.89 cM)5
123851 NM_009818.11 NP_033948.11
351189125 |
chicken
(Gallus gallus) |
Aves |
CTNNA11 |
catenin (cadherin-associated protein), alpha 1, 102kDa |
84.35(n)
98.01(a) |
|
416184 XM_414513.3 XP_414513.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CTNNA16 |
-- |
97(a) |
1 ↔ 1 |
1(131730505-131815656) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.110822 |
Transcribed sequence with strong similarity to protein more |
82.87(n) |
|
BX683605.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ctnna2 |
catenin (cadherin-associated protein), alpha |
77.86(n) |
|
30741 AF099737.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
alpha-Cat3 |
cell adhesion actin binding |
59(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
hmp-13 |
alpha-catenin |
38(a) |
|
V(11848474-11854366) -- |
ENSEMBL Gene Tree for CTNNA1 (if available)
TreeFam Gene Tree for CTNNA1 (if available) |
Paralogs
for CTNNA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CTNNA1 gene
- CTNNA22 CTNNA32 VCL2 CTNNAL12
2 SIMAP similar genes for CTNNA1 using alignment to 32 protein entries: CTNA1_HUMAN (see all proteins):CTNNA2 CTNNA3
CTNNA1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for CTNNA1
PGOHUM00000240613 PGOHUM00000257111
|
Genomic Variants
for CTNNA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CTNNA1 (137946656 - 138196656 bp, first 250kb of CTNNA1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CTNNA1
1 Indel: 46775 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTNNA1 |
|
Disorders
/ Diseases
for CTNNA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CTNNA1 for disorders About GeneDecksing
OMIM gene information: 116805
OMIM disorders: --
20/83  diseases for CTNNA1 (see all 83): About MalaCardscarcinoma renal carcinoma familial adenomatous polyposis adenomatous polyposis coli
barrett's esophagus nonpapillary renal cell carcinoma squamous cell carcinoma malignant mesothelioma
basaloid squamous cell carcinoma bile duct carcinoma inflammatory bowel disease laryngeal squamous cell carcinoma
cutaneous malignant melanoma adenoid cystic carcinoma oral squamous cell carcinoma esophageal squamous cell carcinoma
renal cell carcinoma desmoid tumor gallbladder carcinoma polyposis
10/71 Novoseek disease relationships for CTNNA1 gene (see all 71) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| metastasis |
57.5 |
56 |
10461060 (4), 7629995 (4), 7565577 (4), 9624037 (3) (see all 27) |
| colon carcinoma |
55.9 |
20 |
8081881 (2), 9166410 (1), 18690644 (1), 9700171 (1) (see all 13) |
| carcinoma |
54.8 |
37 |
15948257 (2), 11554165 (2), 7887451 (2), 10709091 (2) (see all 24) |
| carcinoma lobular |
53.5 |
3 |
8188525 (1), 17143261 (1) |
| tumors |
52.6 |
122 |
16554911 (4), 17316610 (3), 9234707 (3), 17989230 (3) (see all 66) |
| familial adenomatous polyposis |
52.1 |
5 |
10207085 (1), 10681434 (1), 9024698 (1), 9110993 (1) |
| cancer |
42.9 |
47 |
17945508 (3), 10343606 (3), 19458087 (3), 11096236 (2) (see all 26) |
| colon cancer |
37.7 |
16 |
10896949 (2), 7629995 (2), 15051498 (2), 9809040 (1) (see all 10) |
| gastric carcinoma |
35.8 |
8 |
15948257 (4), 15133841 (1), 15128072 (1) |
| bladder carcinoma |
34.7 |
4 |
16413663 (2), 16554911 (2) |
Human Genome Epidemiology (HuGE) Navigator: CTNNA1 (3 documents)
Export disorders for CTNNA1 gene to outside databases
|
Publications
for CTNNA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CTNNA1 gene, integrated from 9 sources (see all 520):
(articles sorted by number of sources associating them with CTNNA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning reveals alternative splice forms of human alpha(E)- catenin. (PubMed id 7945318)1, 2, 9 Rimm D.L.... Morrow J.S. (1994)
- The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. (PubMed id 1924379)1, 3, 9 Herrenknecht K....Kemler R. (1991)
- Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)1, 2 Beranova-Giorgianni S.... Giorgianni F. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. (PubMed id 12417594)1, 2 Marie H.... Braga V.M. (2003)
- Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
- Assignment of the human alpha-catenin gene (CTNNA1) to chromosome 5q21-q22. (PubMed id 8188230)1, 2 McPherson J.D.... Isaacs W.B. (1994)
- Structure, expression and chromosome assignment of the human catenin (cadherin-associated protein) alpha 1 gene (CTNNA1). (PubMed id 8404069)1, 2 Furukawa Y.... Horii A. (1994)
|
External Searches for CTNNA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CTNNA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CTNNA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CTNNA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CTNNA1 gene:
Search GeneIP for patents involving CTNNA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CTNNA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CTNNA1 | | OriGene shRNA RFP for CTNNA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTNNA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTNNA1 | | | OriGene Protein Over-expression Lysate for CTNNA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CTNNA1 | | OriGene 3'-UTR Clone for CTNNA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTNNA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTNNA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CTNNA1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CTNNA1 | | OriGene Custom Protein Services for CTNNA1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTNNA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTNNA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTNNA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTNNA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTNNA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTNNA1 |
| |
 |  |  |  | |
| | Antibodies & Assays for CTNNA1 |
| | | | Search Tocris compounds for CTNNA1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNA1 |
|  |  |  | | | | ThermoFisher Antibody for CTNNA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTNNA1 |
|
|
|
|
