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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTNNA1 Gene

protein-coding   GIFtS: 66
GCID: GC05P137947

Catenin (Cadherin-Associated Protein), Alpha 1, 102kDa

(Previous names: catenin (cadherin-associated protein), alpha 1 (102kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Catenin (Cadherin-Associated Protein), Alpha 1, 102kDa1 2     alpha-catenin2
Alpha E-Catenin2 3     alphaE-catenin2
Renal Carcinoma Antigen NY-REN-132 3     Cadherin-Associated Protein,102kDa2
Catenin (Cadherin-Associated Protein), Alpha 1 (102kD)1     Catenin Alpha-12
CAP1022     Cadherin-Associated Protein3
alpha-E-catenin2     

External Ids:    HGNC: 25091   Entrez Gene: 14952   Ensembl: ENSG000000441157   OMIM: 1168055   UniProtKB: P352213   

Export aliases for CTNNA1 gene to outside databases

Previous GC identifers: GC05P137992 GC05P138765 GC05P138119 GC05P138165 GC05P138193 GC05P138117 GC05P133278


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CTNNA1 Gene: 
CTNNA1 (catenin (cadherin-associated protein), alpha 1, 102kDa) is a protein-coding gene. Diseases associated with CTNNA1 include chromosome 5q deletion, and nonpapillary renal cell carcinoma, and among its related super-pathways are Hypertrophic cardiomyopathy (HCM) and Cell-cell junction organization. GO annotations related to this gene include beta-catenin binding and structural molecule activity. An important paralog of this gene is CTNNA2.

UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221
Function: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to
cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary
importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally
believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of
cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more
dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the
complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may
regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to
actin filaments. May play a crucial role in cell differentiation

Gene Wiki entry for CTNNA1 (Catenin, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTNNA1 gene promoter:
         HOXA9B   HOXA9   GR   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   IRF-1   POU3F2   GR-alpha   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTNNA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CTNNA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTNNA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.2   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31.2

CTNNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTNNA1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P137947:  view genomic region     (about GC identifiers)

Start:
137,946,656 bp from pter      End:
138,270,723 bp from pter
Size:
324,068 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221 (See protein sequence)
Recommended Name: Catenin alpha-1  
Size: 906 amino acids; 100071 Da
Subunit: Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin. Binds MLLT4
and F-actin. Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and
beta-catenin/CTNNB1 or gamma-catenin/JUP; the complex is located to adherens junctions. The stable association of
CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively,
the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Interacts with ARHGAP21
and with AJUBA. Interacts with LIMA1 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral
membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix
boundaries
3 PDB 3D structures from and Proteopedia for CTNNA1:
1H6G (3D)        4EHP (3D)        4IGG (3D)    
Secondary accessions: Q12795
Alternative splicing: 2 isoforms:  P35221-1   P35221-2   

Explore the universe of human proteins at neXtProt for CTNNA1: NX_P35221

Explore proteomics data for CTNNA1 at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35221

  • CTNNA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CTNNA1 Protein Expression
    REFSEQ proteins: NP_001894.2  
    ENSEMBL proteins: 
     ENSP00000428439   ENSP00000429636   ENSP00000428049   ENSP00000430304   ENSP00000428202  
     ENSP00000431033   ENSP00000304669   ENSP00000430626   ENSP00000430671   ENSP00000428457  
     ENSP00000430078   ENSP00000429457   ENSP00000427821   ENSP00000429142   ENSP00000429738  
     ENSP00000430379   ENSP00000429569   ENSP00000428044   ENSP00000430841   ENSP00000428088  
     ENSP00000431118   ENSP00000430240   ENSP00000429103   ENSP00000430177   ENSP00000430981  
     ENSP00000430623   ENSP00000428894   ENSP00000428710   ENSP00000428686   ENSP00000430076  
     ENSP00000347190   ENSP00000438476  
    Reactome Protein details: P35221
    Human Recombinant Protein Products for CTNNA1: 
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    Novus Biologicals CTNNA1 Proteins
    Novus Biologicals CTNNA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction IDA10460003

    CTNNA1 for ontologies           About GeneDecksing



    CTNNA1 Antibody Products: 
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    Assay Products for CTNNA1: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR006077 Vinculin/catenin
     IPR000633 Vinculin_CS
     IPR001033 Alpha_catenin

    Graphical View of Domain Structure for InterPro Entry P35221

    ProtoNet protein and cluster: P35221

    1 Blocks protein domain: IPB001033 Alpha-catenin signature

    UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221
    Similarity: Belongs to the vinculin/alpha-catenin family


    CTNNA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTNA1_HUMAN, P35221
    Function: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to
    cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary
    importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally
    believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of
    cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more
    dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the
    complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may
    regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to
    actin filaments. May play a crucial role in cell differentiation

         Genatlas biochemistry entry for CTNNA1:
    catenin alpha 1,102kDa,desmosomal plaque component,regulating cell adhesion (component of the E cadherin
    multiprotein complex

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding IPI12477722
    GO:0008013beta-catenin binding IPI7650039
    GO:0017166vinculin binding IPI9700171
    GO:0045295gamma-catenin binding IPI7650039
         
    CTNNA1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CTNNA1:
     Altered focal adhesion (FA) or  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ctnna1):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size  integument  limbs/digits/tail  mortality/aging  muscle 
     nervous system  other  skeleton  tumorigenesis 

    CTNNA1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CTNNA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTNNA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTNNA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTNNA1 

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CTNNA1 (see all 22):
    hsa-miR-4328 hsa-miR-875-5p hsa-miR-200a hsa-miR-197 hsa-miR-141 hsa-miR-9 hsa-miR-1184 hsa-miR-891b
    SwitchGear 3'UTR luciferase reporter plasmidCTNNA1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CTNNA1 About   (see all 31)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Arrhythmogenic right ventricular cardiomyopathy0.53
    2Cell-cell junction organization
    Cell-cell junction organization0.69
    Cell-Cell communication0.64
    Cell junction organization0.69
    Adherens junctions interactions0.51
    3Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    4CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    5CDC42 signaling events
    RAC1 signaling pathway0.34
    CDC42 signaling events0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for CTNNA1
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Cadherin-mediated cell adhesion
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CTNNA1 (see all 10)
        Sertoli-Sertoli Cell Junction Dynamics
    Remodeling of Adherens Junctions
    Internalin Pathway
    Molecular Mechanisms of Cancer
    Transendothelial Migration of Leukocytes

    1 Cell Signaling Technology (CST) Pathway for CTNNA1
        Adhesion

    3 GeneGo (Thomson Reuters) Pathways for CTNNA1
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Cadherin-mediated cell adhesion

    5/10 BioSystems Pathways for CTNNA1 (see all 10)
        Arrhythmogenic right ventricular cardiomyopathy
    CDC42 signaling events
    E-cadherin signaling in keratinocytes
    E-cadherin signaling in the nascent adherens junction
    Nectin adhesion pathway

    5/7        Reactome Pathways for CTNNA1 (see all 7)
        Developmental Biology
    Adherens junctions interactions
    Myogenesis
    Cell junction organization
    CDO in myogenesis


    5/8         Kegg Pathways  (Kegg details for CTNNA1) (see all 8):
        Hippo signaling pathway
    Adherens junction
    Tight junction
    Leukocyte transendothelial migration
    Bacterial invasion of epithelial cells


    CTNNA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTNNA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/141 Interacting proteins for CTNNA1 (P352212, 3 ENSP000003046694) via UniProtKB, MINT, STRING, and/or I2D (see all 141)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD3Q8TEW02, 3, ENSP000003639214MINT-4085250 I2D: score=1 STRING: ENSP00000363921
    CTNNB1P352222, 3, ENSP000003444564MINT-7010191 MINT-46006 I2D: score=9 STRING: ENSP00000344456
    CDH1P128302, 3, ENSP000002617694MINT-7010191 I2D: score=6 STRING: ENSP00000261769
    CDH5P331512, 3, ENSP000003441154MINT-4085212 I2D: score=2 STRING: ENSP00000344115
    CTBP1Q133632, 3, ENSP000002909214MINT-8253858 I2D: score=2 STRING: ENSP00000290921
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0007155cell adhesion IEA--
    GO:0007163establishment or maintenance of cell polarity IEA--
    GO:0007406negative regulation of neuroblast proliferation IEA--
    GO:0007568aging IEA--

    CTNNA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CTNNA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for CTNNA1 (CTNA1)

    10/15 Novoseek inferred chemical compound relationships for CTNNA1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 48.2 44 9233779 (4), 11710913 (4), 14517306 (2), 9326449 (2) (see all 24)
    phalloidin 43.5 1 10075198 (1)
    paraffin 35.4 5 12800081 (1), 10506713 (1), 19783961 (1), 11745187 (1) (see all 5)
    phosphotyrosine 27.4 2 19639172 (1)
    p00001 13.2 8 11964044 (2), 11054718 (1)
    12-o-tetradecanoylphorbol 13-acetate 10.4 5 9166410 (2), 9010457 (1), 11329379 (1)
    sphingosine 9.23 6 11489917 (3)
    glycogen 6.56 1 18084253 (1)
    5-aza-2'deoxycytidine 2.56 1 16887905 (1)
    vanadate 0 1 9326449 (1)

    Search CenterWatch for drugs/clinical trials and news about CTNNA1 / CTNA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for CTNNA1 gene: 
    NM_001903.2  

    Unigene Clusters for CTNNA1:

    Catenin (cadherin-associated protein), alpha 1, 102kDa
    Hs.445981  [show with all ESTs], Hs.656653  [show with all ESTs]
    Unigene Representative Sequences: NM_001903, NM_015564
    18/45 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 45):
    ENST00000517980 ENST00000522227 ENST00000524127 ENST00000523912 ENST00000520339
    ENST00000521724 ENST00000302763(uc003ldh.3 uc011cyx.2 uc011cyy.2 uc003ldi.3 uc003ldj.3)
    ENST00000518910 ENST00000521941 ENST00000519309 ENST00000518245 ENST00000519113
    ENST00000520158 ENST00000518825 ENST00000518585 ENST00000518919 ENST00000523275
    ENST00000522730
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    Additional mRNA sequence: 

    AB007876.1 AK291064.1 AK297332.1 AK309790.1 AY182026.1 BC126408.1 BC126410.1 BC143926.1 

    24/81 DOTS entries (see all 81):

    DT.100039653  DT.411950  DT.92465907  DT.100877550  DT.97860742  DT.95099198  DT.95099213  DT.100877566 
    DT.100877563  DT.100877557  DT.40116642  DT.100698423  DT.95099210  DT.100803613  DT.120805841  DT.120805769 
    DT.95213446  DT.100647294  DT.120805830  DT.100877547  DT.454141  DT.97793731  DT.120805739  DT.92465923 

    24/699 AceView cDNA sequences (see all 699):

    AU133743 CB851518 AA233514 BU180143 CF453550 BG285948 BP344506 BQ437676 
    AA677769 BE409008 BU686641 BU195714 AU117876 BM912812 AU126094 BE385260 
    BU556908 BE713195 AU125224 BQ083229 BM837328 AA910494 BQ447334 BF833058 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for CTNNA1 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a · 13b ^ 14 ^ 15a ·
    SP1:                    -     -                             -           -                             -     -     -     -     -     -     -     -     -     -   
    SP2:                                                                                                                                      -     -     -     -   
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                                      -     -               
    SP5:                                                                                                                                      -                     

    ExUns: 15b ^ 16 ^ 17a · 17b · 17c · 17d · 17e · 17f ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b · 26c
    SP1:  -                                   -     -                                                     -     -                           
    SP2:  -                                   -     -                                                     -     -                           
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for CTNNA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTNNA1 expression in normal human tissues (normalized intensities)      CTNNA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGAAAAT
    CTNNA1 Expression
    About this image


    CTNNA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             brain/forebrain/telencephalon   
     
     Lung (Respiratory System)    fully expand to see all 6 entries
             Stem Bronchi
             lung ; pneumocytes   
             trachea   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 3 entries
             Ureter
             urinary bladder ; urothelial cells   
             visceral organ   
     
     Nose (Sensory Organs)    fully expand to see all 3 entries
             nasopharynx ; respiratory epithelial cells   
             sensory organ/nose   

    See CTNNA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTNNA1

    SOURCE GeneReport for Unigene clusters: Hs.445981 Hs.656653

    UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221
    Tissue specificity: Expressed ubiquitously in normal tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including CTNNA1: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Tumor Metastasis in human mouse rat
              Stem Cells in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CTNNA1 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctnna11 , 5 catenin (cadherin associated protein), alpha 11, 5 91.83(n)1
    99.45(a)1
      18 (18.89 cM)5
    123851  NM_009818.11  NP_033948.11 
     351189125 
    chicken
    (Gallus gallus)
    Aves CTNNA11 catenin (cadherin-associated protein), alpha 1, 102kDa 84.35(n)
    98.01(a)
      416184  XM_414513.3  XP_414513.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTNNA16
    Uncharacterized protein
    97(a)
    1 ↔ 1
    1(131713563-131816823)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.110822 Transcribed sequence with strong similarity to protein more 82.87(n)    BX683605.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ctnna2 catenin (cadherin-associated protein), alpha 77.86(n)   30741  AF099737.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alpha-Cat3 cell adhesion actin binding 59(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea hmp-13 alpha-catenin 38(a)   V(11848474-11854366)   --


    ENSEMBL Gene Tree for CTNNA1 (if available)
    TreeFam Gene Tree for CTNNA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTNNA1 gene
    CTNNA22  CTNNA32  VCL2  CTNNAL12  
    2 SIMAP similar genes for CTNNA1 using alignment to 32 protein entries:     CTNA1_HUMAN (see all proteins):
    CTNNA2    CTNNA3

    CTNNA1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CTNNA1
    PGOHUM00000240613 PGOHUM00000257111


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3321 SNPs in CTNNA1 are shown (see all 3321)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2074664281,2
    Cuntested1138239147(+) AGTACC/TGTGTA 1 -- int10--------
    rs2003258991,2
    C--138087248(+) GGTTCA/CCTGCA 1 -- us2k10--------
    rs1825570211,2
    --138087583(+) ACCCAA/CAGATG 1 -- us2k10--------
    rs768864921,2
    C--138087587(+) ACAGAC/TGTTCA 1 -- us2k10--------
    rs1143707081,2
    F--138087616(+) ATGGGC/GAATGT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1867407511,2
    --138087623(+) ATGTGC/GTGGGT 1 -- us2k10--------
    rs1124849761,2
    F--138087695(+) GTGAGG/TAGTAG 1 -- us2k12Minor allele frequency- T:0.10CSA WA 120
    rs1161119971,2
    C,F--138087821(+) TATCTT/CATTCA 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs7006161,2
    C,F,A,H--138087873(-) TATCAG/TCCTGG 1 -- us2k121Minor allele frequency- T:0.28NS EA WA NA CSA 2348
    rs1420676231,2
    C--138087910(+) TTGTG-/TTGT  
            
    TTGTT
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CTNNA1 (137946656 - 138196656 bp, first 250kb of CTNNA1)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CTNNA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1333927CNV Deletion17803354
    esv2675323CNV Deletion23128226
    esv2200225CNV Deletion18987734
    esv2672371CNV Deletion23128226
    esv2730824CNV Deletion23290073
    esv2659340CNV Deletion23128226
    esv2730822CNV Deletion23290073
    esv2730823CNV Deletion23290073


    Human Gene Mutation Database (HGMD): CTNNA1
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CTNNA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 116805    OMIM disorders: --

    20/72 diseases for CTNNA1 (see all 72):    About MalaCards
    chromosome 5q deletion    nonpapillary renal cell carcinoma    colonic neoplasm    bile duct carcinoma
    basaloid squamous cell carcinoma    malignant mesothelioma    desmoid tumor    adenoiditis
    barrett's esophagus    testicular cancer    thymoma    prostate adenocarcinoma
    fibromatosis    chordoma    esophagitis    bladder carcinoma
    gastric cancer    mucoepidermoid carcinoma    familial adenomatous polyposis    adenocarcinoma


    CTNNA1 for disorders           About GeneDecksing

    10/71 Novoseek inferred disease relationships for CTNNA1 gene (see all 71)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 57.5 56 10461060 (4), 7629995 (4), 7565577 (4), 9624037 (3) (see all 27)
    colon carcinoma 55.9 20 8081881 (2), 9166410 (1), 18690644 (1), 9700171 (1) (see all 13)
    carcinoma 54.8 37 15948257 (2), 11554165 (2), 7887451 (2), 10709091 (2) (see all 24)
    carcinoma lobular 53.5 3 8188525 (1), 17143261 (1)
    tumors 52.6 122 16554911 (4), 17316610 (3), 9234707 (3), 17989230 (3) (see all 66)
    familial adenomatous polyposis 52.1 5 10207085 (1), 10681434 (1), 9024698 (1), 9110993 (1)
    cancer 42.9 47 17945508 (3), 10343606 (3), 19458087 (3), 11096236 (2) (see all 26)
    colon cancer 37.7 16 10896949 (2), 7629995 (2), 15051498 (2), 9809040 (1) (see all 10)
    gastric carcinoma 35.8 8 15948257 (4), 15133841 (1), 15128072 (1)
    bladder carcinoma 34.7 4 16413663 (2), 16554911 (2)

    Genetic Association Database (GAD): CTNNA1
    Human Genome Epidemiology (HuGE) Navigator: CTNNA1 (3 documents)

    Export disorders for CTNNA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTNNA1 gene, integrated from 9 sources (see all 531):
    (articles sorted by number of sources associating them with CTNNA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning reveals alternative splice forms of human alpha(E)- catenin. (PubMed id 7945318)1, 2, 9 Rimm D.L.... Morrow J.S. (1994)
    2. The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. (PubMed id 1924379)1, 3, 9 Herrenknecht K....Kemler R. (1991)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)1, 2 Beranova-Giorgianni S.... Giorgianni F. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. (PubMed id 12417594)1, 2 Marie H.... Braga V.M. (2003)
    9. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    10. Assignment of the human alpha-catenin gene (CTNNA1) to chromosome 5q21-q22. (PubMed id 8188230)1, 2 McPherson J.D.... Isaacs W.B. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1495 HGNC: 2509 AceView: CTNNA1 Ensembl:ENSG00000044115 euGenes: HUgn1495
    ECgene: CTNNA1 Kegg: 1495 H-InvDB: CTNNA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTNNA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTNNA1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ctnna1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CTNNA1 gene:
    Search GeneIP for patents involving CTNNA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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