Aliases for CTNNA1 Gene
External Ids for CTNNA1 Gene
Previous GeneCards Identifiers for CTNNA1 Gene
GeneCards Summary for CTNNA1 Gene
CTNNA1 (Catenin Alpha 1) is a Protein Coding gene. Diseases associated with CTNNA1 include macular dystrophy, butterfly-shaped pigmentary, 2 and diffuse gastric cancer. Among its related pathways are Adherens junction and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include poly(A) RNA binding and actin filament binding. An important paralog of this gene is CTNNA3.
UniProtKB/Swiss-Prot for CTNNA1 Gene
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.