V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

CTNNA1 Gene

protein-coding GIFtS: 68

GC05P138117

catenin (cadherin-associated protein), alpha 1, 102kDa
(Previous names: catenin (cadherin-associated protein), alpha 1 (102kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CAP102 ^¹, ²
FLJ36832 ^²
FLJ52416 ^²
alpha-E-catenin ^²
alpha-catenin ^²
alphaE-catenin ^²

Descriptions
Alpha E-catenin ^³
Cadherin-associated protein ^³
NY-REN-13 antigen ^³
cadherin-associated protein,102kDa ^²
catenin (cadherin-associated protein), alpha 1 (102kD) ^¹, ²
catenin (cadherin-associated protein), alpha 1, 102kDa ^²
catenin, alpha 1 ^²

External Ids
HGNC: 2509¹
Entrez Gene: 1495²
UniProtKB: P35221³
Ensembl: ENSG00000044115⁷

Search outside databases for aliases for CTNNA1 gene

Previous GC identifers: GC05P137992 GC05P138765 GC05P138119 GC05P138165 GC05P138193

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221

Function: Associates with the cytoplasmic domain of a variety of cadherins. The association of

catenins to cadherins produces a complex which is linked to the actin filament network, and which

seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role

in cell differentiation

Gene Wiki entry for CTNNA1 (Catenin%2C_alpha_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CTNNA1 gene

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31.2

CTNNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P138117: (about GC identifiers)

Start:	138,117,006 bp from pter
End:	138,298,622 bp from pter
Size:	181,617 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_034772.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221 (See protein sequence)

Recommended Name: Catenin alpha-1

Size: 906 amino acids; 100071 Da

Subunit: Binds MLLT4 and F-actin (By similarity). Interacts directly with PSEN1 and CTNNB1 to form

part of the PSEN1/cadherin/catenin adhesion complex. Interacts with ARHGAP21 and with JUB

Subcellular location: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane;

Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries

and probably at cell-matrix boundaries

PDB structure from and Proteopedia :

1H6G (3D)

1L7C (3D)

Secondary accessions: Q12795

Alternative splicing: 2 isoforms: P35221-1 P35221-2

Post-translational modifications:

Sumoylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001894.2

ENSEMBL proteins:

ENSP00000304669 ENSP00000347190

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (alpha 1 Catenin)
	Human Recombinant Proteins from Abnova (CTNNA1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0015629	actin cytoskeleton	IEA	--
GO:0030054	cell junction	IEA	--

About this table

Antibodies for CTNNA1:

	Invitrogen Antibodies for CTNNA1
	Millipore Mono- and Polyclonal Antibodies for the study of CTNNA1
	Sigma-Aldrich Antibody Arrays and Antibodies for CTNNA1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for CTNNA1 (Alpha-E-Catenin)
	Antibodies from Abcam (alpha 1 Catenin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CTNNA1)
	Novus Biologicals Antibodies for CTNNA1

Assays for CTNNA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P35221

ProtoNet protein and cluster: P35221

1 Blocks protein family: IPB001033 Alpha-catenin signature

UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221

Similarity: Belongs to the vinculin/alpha-catenin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CTNNA1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001903

Applied Biosystems Silencer® siRNAs for CTNNA1

Sigma-Aldrich siRNA for CTNNA1

Sigma-Aldrich shRNA Panels and shRNA for CTNNA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CTNNA1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001903
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001903
untagged cDNA clone in CMV expression vector: NM_001903

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001903

UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221

Function: Associates with the cytoplasmic domain of a variety of cadherins. The association of

catenins to cadherins produces a complex which is linked to the actin filament network, and which

seems to be of primary importance for cadherins cell-adhesion properties. May play a crucial role

in cell differentiation

Genatlas biochemistry entry for CTNNA1:

catenin alpha 1,102kDa,desmosomal plaque component,regulating cell adhesion (component of the E

cadherin multiprotein complex

15 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ctnna1):

cellular	craniofacial	embryogenesis	endocrine/exocrine gland	growth/size
lethality-postnatal	lethality-prenatal/perinatal	limbs/digits/tail	nervous system	normal
other	reproductive system	skin/coat/nails	touch/vibrissae	tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--
GO:0005515	protein binding	IPI	12477722
GO:0017166	vinculin binding	IPI	9700171
GO:0045296	cadherin binding	IPI	12734196

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5 Sigma-Aldrich "Your Favorite Gene" Pathways for CTNNA1 (Your Favorite Gene powered by Ingenuity)

Molecular Mechanisms of Cancer
Endometrial Cancer Signaling
Germ Cell-Sertoli Cell Junction Signaling
Tight Junction Signaling
Leukocyte Extravasation Signaling

GeneDecks CTNNA1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CTNNA1

5/70 Interacting proteins for CTNNA1 (ENSP00000347190³ P35221²) via UniProtKB, MINT, and/or STRING (see all 70 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CTNNB1	P35222²	STRING (score=.999) MINT-7010191 MINT-46006
CDH1	P12830²	STRING (score=.999) MINT-7010191
CDH5	P33151²	STRING (score=.933) MINT-4085212
PARD3	Q8TEW0²	MINT-4085250
JUP	ENSP00000311113³	STRING (score=.999)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	NAS	8323564
GO:0043297	apical junction assembly	NAS	9700171

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CTNNA1
10 Novoseek chemical compound relationships for CTNNA1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	47.77	41	9233779 (4), 11710913 (4), 14517306 (2), 9326449 (2) (see all 22)
phalloidin	44.96	1	10075198 (1)
p00001	13.94	8	11964044 (2), 11054718 (1)
12-o-tetradecanoylphorbol 13-acetate	11.50	5	9166410 (2), 9010457 (1), 11329379 (1)
sphingosine	11.20	6	11489917 (3)
glycogen	8.62	1	18084253 (1)
oligonucleotide	0.00	2	7625768 (1)
calcium	0.00	1	8846022 (1)
p005	0.00	1	15916880 (1)
vanadate	0.00	1	9326449 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CTNNA1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001903

Sigma-Aldrich siRNA for CTNNA1

Sigma-Aldrich shRNA Panels and shRNA for CTNNA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001903

REFSEQ mRNAs for CTNNA1 gene:

NM_001903.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001903

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001903
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001903
                                 untagged cDNA clone in CMV expression vector: NM_001903

Additional cDNA sequence:

AB007876.1 AK291064.1 AK297332.1 AK309790.1 AY182026.1 BC126408.1 BC126410.1 BC143926.1

CR600503.1

24/82 DOTS entries (see all 82 ):

DT.100039653 DT.411950 DT.92465907 DT.100877550 DT.97860742 DT.95099198 DT.95099213 DT.100877566

DT.100877563 DT.100877557 DT.40116642 DT.100698423 DT.95099210 DT.100803613 DT.120805841 DT.120805769

DT.100647294 DT.95213446 DT.120805830 DT.97793731 DT.100877547 DT.454141 DT.120805739 DT.92465923

24/699 AceView cDNA sequences (see all 699 ):

AU280214 BM800769 CF453550 BQ720702 AI658642 BQ945306 CA442351 BU838528

AU126094 BI752235 BQ073345 BQ889431 BU736985 BG287605 BQ921630 BU528625

BQ883592 AL548097 BQ680753 BU194833 BQ878900 BQ437676 BM750503 BU196799

highest scoring ESTs for CTNNA1:

D14705 L23805 U03100 AA010701 AA043851 AA056728 AA058899 AA088699 AA090384 AA121163

Unigene Clusters for CTNNA1:

Catenin (cadherin-associated protein), alpha 1, 102kDa

Hs.534797 [show with all ESTs], Hs.656653 [show with all ESTs]

Unigene Representative Sequences: NM_001903, NM_015564

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for CTNNA1 (see all 18 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	·	11c	·	11d	·	11e	^	12	^	13a	·	13b	^	14	^	15a	·
SP1:							-		-										-				-										-		-		-		-		-		-		-		-		-		-
SP2:																																													-		-		-		-
SP3:																																													-
SP4:																																													-		-
SP5:																																													-

ExUns:	15b	^	16	^	17a	·	17b	·	17c	·	17d	·	17e	·	17f	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23	^	24a	·	24b	^	25a	·	25b	^	26a	·	26b	·	26c
SP1:	-												-		-																		-		-
SP2:	-												-		-																		-		-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CTNNA1

2 Ensembl transcripts including schematic representations:

ENST00000302763 ENST00000355078

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CTNNA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CTNNA1

¹ / ² / ³

20 probe-sets matching CTNNA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41153_f_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.08	AF102803	0.20	1.00	0.72	1
41155_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.14	U03100	1.00	1.00	1.00	1
73090_g_at²^{, 3}	U95-E	1	1.00	1.00	0.95	1.26	AA700838	0.80	1.00	0.91	1
41154_r_at²^{, 3}	U95-A	1	1.00	1.00	0.86	0.54	AF102803	0.20	1.00	0.72	1
41156_g_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.05	U03100	1.00	1.00	1.00	1
2069_s_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.01	L23805	1.00	1.00	1.00	1
2085_s_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.89	D14705	1.00	1.00	1.00	1
73092_at²^{, 3}	U95-E	1	0.56	1.00	0.89	1.13	AA781015	0.40	1.00	0.76	1
73088_at²^{, 3}	U95-E	1	0.50	1.00	0.92	0.91	AA700838	0.80	1.00	0.91	1
210844_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D14705	1.00	1.00	1.00	1
200765_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001903	0.60	1.00	0.82	1
200764_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI826881	0.60	1.00	0.82	1
215883_at*²^{, 3}	U133-A	1	1.00	1.00	--	--	AK022326	0.60	1.00	0.82	1
217366_at*²	U133-A	NULL	0.00	0.00	--	--	--	--	--	--	--
210844_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200765_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200764_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1558214_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215883_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217366_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks CTNNA1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAATGAAAAT

SOURCE GeneReport for Unigene clusters: Hs.534797 Hs.656653
Expression variation in blood from EXPOLDB for CTNNA1
UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221
Tissue specificity: Expressed ubiquitously in normal tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CTNNA1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	CTNNA1¹	--	catenin (cadherin-associated protein), alpha 1, 102kDa	99.56(n) 99.89(a)	450165 XM_001171986.1 XP_001171986.1
cow (Bos taurus)	CTNNA1¹	--	catenin (cadherin-associated protein), alpha 1, 102kDa	93.64(n) 99.12(a)	526848 NM_001035366.1 NP_001030443.1
rat (Rattus norvegicus)	Ctnna1¹	--	catenin (cadherin associated protein), alpha 1	90.21(n) 99.45(a)	307505 NM_001007145.1 NP_001007146.1
mouse (Mus musculus)	Ctnna1^{1, 5}	18 (11.00 cM)⁵	catenin (cadherin associated protein), alpha 1^{1, 5}	91.83(n)¹ 99.45(a)¹	12385¹ NM_009818.1¹ NP_033948.1¹ AA517462⁵ AI988031⁵ (see all 26)
chicken (Gallus gallus)	CTNNA1¹	--	catenin (cadherin-associated protein), alpha 1, 102kDa	84.35(n) 98.01(a)	416184 XM_414513.2 XP_414513.1

About this table Species with no ortholog for CTNNA1

ENSEMBL Gene Tree for CTNNA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CTNNA1 gene

CTNNA2² CTNNA3²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1034 NCBI SNPs in CTNNA1 are shown (see all 1034 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 358)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3749663^1,2	A,C,F,H	138299086(+)	`TGTTGA/TCATTT`	1	--	ng3¹		6		EU EA WA NA	568
	rs3763016^1,2	A,C,F,H	138298631(+)	`AAGAGC/GCCAAA`	1	--	ng3¹		21		EA NA NS EU WA	3070
	rs700616^1,2	A,C,F,H	138115772(-)	`TATCAG/TCCTGG`	1	--	ng5¹		4		EU EA WA	412
	rs17031^1,2	C,F,H	138298441(-)	`CAAACA/TCTATG`	1	--	ut3¹		18		MN NA NS EU EA WA	1294
--	rs28363503^1,2	C,F	138298195(+)	`ATCAT-/CATGAAGA`	1	--	ut3¹		5		NS	160
--	rs28363406^1,2	C,F	138188184(+)	`ACGTTC/TCGATC`	1	P/S	mis¹		10		NS NA EU EA WA	668
--	rs700618^1,2	A,C	138116017(-)	`GCACCA/GCAGCA`	1	--	ng5¹		0	--	--	--	--
--	rs4211^1,2	C,F	138298507(-)	`ATAGTAATC/- AATCA`	1	--	ut3¹		9		EU NA EA NS	502
--	rs1059043^1,2	H	138281357(+)	`TAGCAG/CCAAAA`	1	P/A	mis¹ ese³		4		EU EA WA	396
	rs28365836^1,2	F	138116655(+)	`GCAGCC/GCTCTC`	1	--	ng5¹		1		EA	852

About this table

HapMap Linkage Disequilibrium images for CTNNA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 116805

UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221

Abnormalities of alpha-catenin are involved in the process of cancer invasion and

metastasis

10/71 Novoseek disease relationships for CTNNA1 gene (see all 71 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	57.04	55	10461060 (4), 7629995 (4), 7565577 (4), 9624037 (3) (see all 26)
carcinoma	55.54	37	15948257 (2), 11554165 (2), 7887451 (2), 10709091 (2) (see all 24)
colon carcinoma	54.85	20	8081881 (2), 9166410 (1), 18690644 (1), 9700171 (1) (see all 13)
carcinoma lobular	54.67	3	8188525 (1), 17143261 (1)
familial adenomatous polyposis	53.38	5	10207085 (1), 10681434 (1), 9024698 (1), 9110993 (1)
tumors	51.97	114	16554911 (4), 17316610 (3), 9234707 (3), 17989230 (3) (see all 61)
cancer	40.08	42	17945508 (3), 10343606 (3), 11096236 (2), 10385365 (2) (see all 25)
gastric carcinoma	37.33	8	15948257 (4), 15133841 (1), 15128072 (1)
colon cancer	35.02	16	10896949 (2), 7629995 (2), 15051498 (2), 9809040 (1) (see all 10)
primary tumor	32.33	5	11455558 (2), 9552044 (1), 8160768 (1), 19124205 (1)

About this table

1 PharmGKB disease relationship for CTNNA1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/454 PubMed articles for CTNNA1 gene (see all 454 ):

The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. (PubMed id 1924379)^{1, 2, 3} Herrenknecht K....Kemler R. (1991)
Molecular cloning reveals alternative splice forms of human alpha(E)- catenin. (PubMed id 7945318)^{1, 3, 4} Rimm D.L.... Morrow J.S. (1994)
Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)^{3, 4} Beranova-Giorgianni S.... Giorgianni F. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)^{3, 4} Gocke C.B.... Kang J. (2005)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. (PubMed id 12417594)^{3, 4} Marie H.... Braga V.M. (2003)
Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. (PubMed id 10635315)^{3, 4} Georgakopoulos A.... Robakis N.K. (1999)
Antigens recognized by autologous antibody in patients with renal-cell carcinoma. (PubMed id 10508479)^{3, 4} Scanlan M.J....Old L.J. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1495	HGNC: 2509	AceView: CTNNA1	Ensembl:ENSG00000044115	euGenes: HUgn1495
ECgene: CTNNA1	H-InvDB: CTNNA1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CTNNA1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ctnna1/

Licensable Technologies for CTNNA1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CTNNA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CTNNA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CTNNA1		Antibodies for CTNNA1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CTNNA1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CTNNA1)
	Antibodies (CTNNA1)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CTNNA1 (Alpha-E-Catenin)

	Recombinant Proteins (alpha 1 Catenin)
	Antibodies (alpha 1 Catenin)

Search OriGene for CTNNA1

Search Tocris compounds for CTNNA1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CTNNA1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
CTNNA1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

CTNNA1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for CTNNA1

Summaries
for CTNNA1

Genomic Location
for CTNNA1

Proteins
for CTNNA1

Protein Domains/
Families
for CTNNA1

Gene Function
for CTNNA1

Pathways & Interactions
for CTNNA1

Drugs & Compounds
for CTNNA1

Transcripts
for CTNNA1

Expression
for CTNNA1

Orthologs
for CTNNA1

Paralogs
for CTNNA1

SNPs/Variants
for CTNNA1

Disorders & Mutations
for CTNNA1

Medical News
for CTNNA1

Publications
for CTNNA1

Search for CTNNA1

Genome Databases showing CTNNA1

Other Databases showing CTNNA1

Specialized Databases showing CTNNA1

Licensable Technologies
for CTNNA1

Services
for CTNNA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CTNNA1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor CTNNA1

Summariesfor CTNNA1

Genomic Locationfor CTNNA1

Proteinsfor CTNNA1

Protein Domains/Familiesfor CTNNA1

Gene Functionfor CTNNA1

Pathways & Interactionsfor CTNNA1

Drugs & Compoundsfor CTNNA1

Transcriptsfor CTNNA1

Expression for CTNNA1

Orthologsfor CTNNA1

Paralogsfor CTNNA1

SNPs/Variantsfor CTNNA1

Disorders & Mutationsfor CTNNA1

Medical Newsfor CTNNA1

Publicationsfor CTNNA1

Search for CTNNA1

Genome Databases showing CTNNA1

Other Databases showing CTNNA1

Specialized Databases showing CTNNA1

Licensable Technologiesfor CTNNA1

Servicesfor CTNNA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CTNNA1

Summaries
for CTNNA1

Genomic Location
for CTNNA1

Proteins
for CTNNA1

Protein Domains/
Families
for CTNNA1

Gene Function
for CTNNA1

Pathways & Interactions
for CTNNA1

Drugs & Compounds
for CTNNA1

Transcripts
for CTNNA1

Expression
for CTNNA1

Orthologs
for CTNNA1

Paralogs
for CTNNA1

SNPs/Variants
for CTNNA1

Disorders & Mutations
for CTNNA1

Medical News
for CTNNA1

Publications
for CTNNA1

Licensable Technologies
for CTNNA1

Services
for CTNNA1