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CTNNA1 Gene

protein-coding   GIFtS: 67
GCID: GC05P137947

Catenin (Cadherin-Associated Protein), Alpha 1, 102kDa

(Previous names: catenin (cadherin-associated protein), alpha 1 (102kD))
  See CTNNA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Catenin (Cadherin-Associated Protein), Alpha 1, 102kDa1 2     alpha-catenin2
Alpha E-Catenin2 3     alphaE-catenin2
Renal Carcinoma Antigen NY-REN-132 3     Cadherin-Associated Protein,102kDa2
Catenin (Cadherin-Associated Protein), Alpha 1 (102kD)1     Catenin Alpha-12
CAP1022     Cadherin-Associated Protein3
alpha-E-catenin2     

External Ids:    HGNC: 25091   Entrez Gene: 14952   Ensembl: ENSG000000441157   OMIM: 1168055   UniProtKB: P352213   

Export aliases for CTNNA1 gene to outside databases

Previous GC identifers: GC05P137992 GC05P138765 GC05P138119 GC05P138165 GC05P138193 GC05P138117 GC05P133278


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CTNNA1 Gene:
CTNNA1 (catenin (cadherin-associated protein), alpha 1, 102kDa) is a protein-coding gene. Diseases associated with CTNNA1 include diffuse gastric cancer, and chromosome 5q deletion. GO annotations related to this gene include beta-catenin binding and structural molecule activity. An important paralog of this gene is CTNNA2.

UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221
Function: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to
cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary
importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally
believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of
cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more
dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the
complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may
regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to
actin filaments. May play a crucial role in cell differentiation

Gene Wiki entry for CTNNA1 (Catenin, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTNNA1 gene promoter:
         HOXA9B   HOXA9   GR   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   IRF-1   POU3F2   GR-alpha   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTNNA1 promoter sequence
   Search Chromatin IP Primers for CTNNA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTNNA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.2   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31.2

CTNNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTNNA1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P137947:  view genomic region     (about GC identifiers)

Start:
137,946,656 bp from pter      End:
138,270,723 bp from pter
Size:
324,068 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221 (See protein sequence)
Recommended Name: Catenin alpha-1  
Size: 906 amino acids; 100071 Da
Subunit: Monomer and homodimer; the monomer preferentially binds to CTNNB1 and the homodimer to actin. Binds MLLT4
and F-actin. Possible component of an E-cadherin/ catenin adhesion complex together with E-cadherin/CDH1 and
beta-catenin/CTNNB1 or gamma-catenin/JUP; the complex is located to adherens junctions. The stable association of
CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively,
the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Interacts with ARHGAP21
and with AJUBA. Interacts with LIMA1 (By similarity)
3 PDB 3D structures from and Proteopedia for CTNNA1:
1H6G (3D)        4EHP (3D)        4IGG (3D)    
Secondary accessions: Q12795 Q8N1C0
Alternative splicing: 3 isoforms:  P35221-1   P35221-2   P35221-3   (Expressed at high levels in the nervous system. Lacks the beta-catenin interaction domain)

Explore the universe of human proteins at neXtProt for CTNNA1: NX_P35221

Explore proteomics data for CTNNA1 at MOPED

Post-translational modifications: 

  • Sumoylated1
  • Ubiquitination2 at Lys12, Lys16, Lys45, Lys178, Lys216, Lys478, Lys797
  • Modification sites at PhosphoSitePlus

  • See CTNNA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001277236.1  NP_001277238.1  NP_001277239.1  NP_001277241.1  NP_001894.2  

    ENSEMBL proteins: 
     ENSP00000428439   ENSP00000429636   ENSP00000428049   ENSP00000430304   ENSP00000428202  
     ENSP00000431033   ENSP00000304669   ENSP00000430626   ENSP00000430671   ENSP00000430078  
     ENSP00000429457   ENSP00000427821   ENSP00000429142   ENSP00000429738   ENSP00000430379  
     ENSP00000429569   ENSP00000428044   ENSP00000430841   ENSP00000428088   ENSP00000431118  
     ENSP00000430240   ENSP00000429103   ENSP00000430177   ENSP00000430981   ENSP00000430623  
     ENSP00000428894   ENSP00000428710   ENSP00000428686   ENSP00000430076   ENSP00000347190  
     ENSP00000438476  
    Reactome Protein details: P35221

    CTNNA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CTNNA1
    OriGene Protein Over-expression Lysate for CTNNA1
    OriGene MassSpec for CTNNA1
    OriGene Custom Protein Services for CTNNA1
    GenScript Custom Purified and Recombinant Proteins Services for CTNNA1
    Novus Biologicals CTNNA1 Proteins
    Novus Biologicals CTNNA1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CTNNA1 

    CTNNA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CTNNA1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CTNNA1 
    OriGene Antibodies for CTNNA1
    OriGene Custom Antibody Services for CTNNA1
    Novus Biologicals CTNNA1 Antibodies
    Abcam antibodies for CTNNA1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CTNNA1
    LSBio Antibodies in human, mouse, rat for CTNNA1

    CTNNA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CTNNA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CTNNA1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CTNNA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR006077 Vinculin/catenin
     IPR000633 Vinculin_CS
     IPR001033 Alpha_catenin

    Graphical View of Domain Structure for InterPro Entry P35221

    ProtoNet protein and cluster: P35221

    1 Blocks protein domain: IPB001033 Alpha-catenin signature

    UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221
    Similarity: Belongs to the vinculin/alpha-catenin family


    Find genes that share domains with CTNNA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTNA1_HUMAN, P35221
    Function: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to
    cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary
    importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally
    believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of
    cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more
    dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the
    complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may
    regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to
    actin filaments. May play a crucial role in cell differentiation

         Genatlas biochemistry entry for CTNNA1:
    catenin alpha 1,102kDa,desmosomal plaque component,regulating cell adhesion (component of the E cadherin
    multiprotein complex

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0005515protein binding IPI12477722
    GO:0008013beta-catenin binding IPI7650039
    GO:0017166vinculin binding IPI9700171
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CTNNA1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CTNNA1:
     Altered focal adhesion (FA) or  Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         14 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ctnna1):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size/body  integument  limbs/digits/tail  mortality/aging  muscle 
     nervous system  other  skeleton  tumorigenesis 

    Find genes that share phenotypes with CTNNA1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTNNA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTNNA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTNNA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTNNA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CTNNA1:
    hsa-mir-615-3p (MIRT039674), hsa-mir-769-3p (MIRT039085), hsa-mir-744-5p (MIRT037739), hsa-mir-155-5p (MIRT020722), hsa-mir-296-3p (MIRT038473)

    Block miRNA regulation of human, mouse, rat CTNNA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTNNA1 (see all 22):
    hsa-miR-4328 hsa-miR-875-5p hsa-miR-200a hsa-miR-197 hsa-miR-141 hsa-miR-9 hsa-miR-1184 hsa-miR-891b
    SwitchGear 3'UTR luciferase reporter plasmidCTNNA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CTNNA1
    Predesigned siRNA for gene silencing in human, mouse, rat CTNNA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CTNNA1

    Clone
    Products:
         
    OriGene clones in human, mouse for CTNNA1 (see all 6)
    OriGene ORF clones in mouse, rat for CTNNA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTNNA1 (NM_001903)
    Sino Biological Human cDNA Clone for CTNNA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTNNA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTNNA1
    Addgene plasmids for CTNNA1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CTNNA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CTNNA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTNNA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTNA1_HUMAN, P35221: Isoform 1: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane;
    Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at
    cell-matrix boundaries
    CTNA1_HUMAN, P35221: Isoform 3: Cell membrane; Peripheral membrane protein; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0005911cell-cell junction IDA10460003

    Find genes that share ontologies with CTNNA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTNNA1 About   (see all 31)  
    See pathways by source

    SuperPathContained pathways About
    1Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Arrhythmogenic right ventricular cardiomyopathy0.54
    2Cell junction organization
    Cell junction organization0.70
    Cell-Cell communication0.64
    Cell-cell junction organization0.70
    Adherens junctions interactions0.49
    3Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    4CDO in myogenesis
    CDO in myogenesis1.00
    Myogenesis1.00
    5CDC42 signaling events
    CDC42 signaling events0.34
    RAC1 signaling pathway0.34


    Find genes that share SuperPaths with CTNNA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CTNNA1 (see all 10)
        Sertoli-Sertoli Cell Junction Dynamics
    Remodeling of Adherens Junctions
    Internalin Pathway
    Molecular Mechanisms of Cancer
    Transendothelial Migration of Leukocytes

    1 Cell Signaling Technology (CST) Pathway for CTNNA1
        Adhesion

    3 GeneGo (Thomson Reuters) Pathways for CTNNA1
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Cadherin-mediated cell adhesion

    Selected BioSystems Pathways for CTNNA1 (see all 10)
        Arrhythmogenic right ventricular cardiomyopathy
    N-cadherin signaling events
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    E-cadherin signaling in keratinocytes
    CDC42 signaling events


    2 Reactome Pathways for CTNNA1
        Adherens junctions interactions
    CDO in myogenesis


    Selected Kegg Pathways  (Kegg details for CTNNA1) (see all 8):
        Hippo signaling pathway
    Adherens junction
    Tight junction
    Leukocyte transendothelial migration
    Bacterial invasion of epithelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTNNA1: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Tumor Metastasis in human mouse rat
              Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CTNNA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTNNA1 (P352212, 3 ENSP000003046694) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD3Q8TEW02, 3, ENSP000003639214MINT-4085250 I2D: score=1 STRING: ENSP00000363921
    CTNNB1P352222, 3, ENSP000003444564MINT-7010191 MINT-46006 I2D: score=9 STRING: ENSP00000344456
    CDH1P128302, 3, ENSP000002617694MINT-7010191 I2D: score=6 STRING: ENSP00000261769
    CDH5P331512, 3, ENSP000003441154MINT-4085212 I2D: score=2 STRING: ENSP00000344115
    CTBP1Q133632, 3, ENSP000002909214MINT-8253858 I2D: score=2 STRING: ENSP00000290921
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0007155cell adhesion NAS8323564
    GO:0007163establishment or maintenance of cell polarity IEA--
    GO:0007406negative regulation of neuroblast proliferation IEA--
    GO:0007568aging IEA--

    Find genes that share ontologies with CTNNA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTNNA1 (CTNA1)

    Selected Novoseek inferred chemical compound relationships for CTNNA1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 48.2 44 9233779 (4), 11710913 (4), 14517306 (2), 9326449 (2) (see all 24)
    phalloidin 43.5 1 10075198 (1)
    paraffin 35.4 5 12800081 (1), 10506713 (1), 19783961 (1), 11745187 (1) (see all 5)
    phosphotyrosine 27.4 2 19639172 (1)
    p00001 13.2 8 11964044 (2), 11054718 (1)
    12-o-tetradecanoylphorbol 13-acetate 10.4 5 9166410 (2), 9010457 (1), 11329379 (1)
    sphingosine 9.23 6 11489917 (3)
    glycogen 6.56 1 18084253 (1)
    5-aza-2'deoxycytidine 2.56 1 16887905 (1)
    vanadate 0 1 9326449 (1)



    Find genes that share compounds with CTNNA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTNNA1 gene (5 alternative transcripts): 
    NM_001290307.1  NM_001290309.1  NM_001290310.1  NM_001290312.1  NM_001903.3  

    Unigene Clusters for CTNNA1:

    Catenin (cadherin-associated protein), alpha 1, 102kDa
    Hs.445981  [show with all ESTs], Hs.656653  [show with all ESTs]
    Unigene Representative Sequences: NM_001903, NM_015564
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 44):
    ENST00000517980 ENST00000522227 ENST00000524127 ENST00000523912 ENST00000520339
    ENST00000521724 ENST00000302763(uc003ldh.3 uc011cyx.2 uc011cyy.2 uc003ldi.3 uc003ldj.3)
    ENST00000518910 ENST00000521941 ENST00000519309 ENST00000519113 ENST00000520158
    ENST00000518825 ENST00000518585 ENST00000518919 ENST00000523275 ENST00000522730
    ENST00000517534
    miRNA
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    Block miRNA regulation of human, mouse, rat CTNNA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTNNA1 (see all 22):
    hsa-miR-4328 hsa-miR-875-5p hsa-miR-200a hsa-miR-197 hsa-miR-141 hsa-miR-9 hsa-miR-1184 hsa-miR-891b
    SwitchGear 3'UTR luciferase reporter plasmidCTNNA1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CTNNA1
    Clone
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    OriGene ORF clones in mouse, rat for CTNNA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTNNA1 (NM_001903)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTNNA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTNNA1
    Addgene plasmids for CTNNA1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CTNNA1
    OriGene qSTAR qPCR primer pairs in human, mouse for CTNNA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTNNA1
      QuantiTect SYBR Green Assays in human, mouse, rat CTNNA1
      QuantiFast Probe-based Assays in human, mouse, rat CTNNA1

    Additional mRNA sequence: 

    AB007876.1 AK291064.1 AK297332.1 AK309790.1 AY182026.1 BC126408.1 BC126410.1 BC143926.1 

    Selected DOTS entries (see all 81):

    DT.100039653  DT.411950  DT.92465907  DT.100877550  DT.97860742  DT.95099198  DT.95099213  DT.100877566 
    DT.100877563  DT.100877557  DT.40116642  DT.100698423  DT.95099210  DT.100803613  DT.120805841  DT.120805769 
    DT.95213446  DT.100647294  DT.120805830  DT.100877547  DT.454141  DT.97793731  DT.120805739  DT.92465923 

    Selected AceView cDNA sequences (see all 699):

    CA427731 AI908124 AL547479 BQ229713 BM837960 H12224 CA422675 BU838202 
    BQ073548 BQ883550 BQ224175 CD516940 AI659938 AA773495 BQ887572 BM849827 
    BQ940366 BM800769 BQ949952 BQ883592 BP345251 CB151429 BQ889431 AU131625 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CTNNA1 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a · 13b ^ 14 ^ 15a ·
    SP1:                    -     -                             -           -                             -     -     -     -     -     -     -     -     -     -   
    SP2:                                                                                                                                      -     -     -     -   
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                                      -     -               
    SP5:                                                                                                                                      -                     

    ExUns: 15b ^ 16 ^ 17a · 17b · 17c · 17d · 17e · 17f ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b · 26c
    SP1:  -                                   -     -                                                     -     -                           
    SP2:  -                                   -     -                                                     -     -                           
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for CTNNA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CTNNA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGAAAAT
    CTNNA1 Expression
    About this image


    CTNNA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    CTNNA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTNNA1 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.445981 Hs.656653

    UniProtKB/Swiss-Prot: CTNA1_HUMAN, P35221
    Tissue specificity: Expressed ubiquitously in normal tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTNNA1: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Adherens Junctions in human mouse rat
              Tight Junctions in human mouse rat
              Tumor Metastasis in human mouse rat
              Stem Cells in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for CTNNA1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctnna11 , 5 catenin (cadherin associated protein), alpha 11, 5 91.83(n)1
    99.45(a)1
      18 (18.89 cM)5
    123851  NM_009818.11  NP_033948.11 
     351189125 
    chicken
    (Gallus gallus)
    Aves CTNNA11 catenin (cadherin-associated protein), alpha 1, 102kDa 84.35(n)
    98.01(a)
      416184  XM_414513.4  XP_414513.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTNNA16
    catenin (cadherin-associated protein), alpha 1, 10...
    97(a)
    1 ↔ 1
    1(131713563-131816823)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.110822 Transcribed sequence with strong similarity to protein more 82.87(n)    BX683605.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ctnna2 catenin (cadherin-associated protein), alpha 77.86(n)   30741  AF099737.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alpha-Cat3 cell adhesion actin binding 59(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea hmp-13 alpha-catenin 38(a)   V(11848474-11854366)   --


    ENSEMBL Gene Tree for CTNNA1 (if available)
    TreeFam Gene Tree for CTNNA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTNNA1 gene
    CTNNA22  CTNNA32  VCL2  CTNNAL12  
    2 SIMAP similar genes for CTNNA1 using alignment to 30 protein entries:     CTNA1_HUMAN (see all proteins):
    CTNNA2    CTNNA3

    Find genes that share paralogs with CTNNA1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CTNNA1
    PGOHUM00000240613 PGOHUM00000257111


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTNNA1 (see all 3321)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2074664281,2
    Cuntested1138239147(+) AGTACC/TGTGTA 1 -- int10--------
    rs2003258991,2
    C--138087248(+) GGTTCA/CCTGCA 1 -- us2k10--------
    rs1825570211,2
    --138087583(+) ACCCAA/CAGATG 1 -- us2k10--------
    rs768864921,2
    C--138087587(+) ACAGAC/TGTTCA 1 -- us2k10--------
    rs1143707081,2
    F--138087616(+) ATGGGC/GAATGT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1867407511,2
    --138087623(+) ATGTGC/GTGGGT 1 -- us2k10--------
    rs1124849761,2
    F--138087695(+) GTGAGG/TAGTAG 1 -- us2k12Minor allele frequency- T:0.10CSA WA 120
    rs1161119971,2
    C,F--138087821(+) TATCTT/CATTCA 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs7006161,2
    C,F,A,H--138087873(-) TATCAG/TCCTGG 1 -- us2k121Minor allele frequency- T:0.28NS EA WA NA CSA 2348
    rs1420676231,2
    C--138087910(+) TTGTG-/TTGT  
            
    TTGTT
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CTNNA1 (137946656 - 138196656 bp, first 250kb of CTNNA1)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CTNNA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1333927CNV Deletion17803354
    esv2675323CNV Deletion23128226
    esv2200225CNV Deletion18987734
    esv2672371CNV Deletion23128226
    esv2730824CNV Deletion23290073
    esv2659340CNV Deletion23128226
    esv2730822CNV Deletion23290073
    esv2730823CNV Deletion23290073

    Human Gene Mutation Database (HGMD): CTNNA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTNNA1
    DNA2.0 Custom Variant and Variant Library Synthesis for CTNNA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116805    OMIM disorders: --

    6 diseases for CTNNA1:    
    About MalaCards
    diffuse gastric cancer    chromosome 5q deletion    hereditary diffuse gastric cancer    lobular neoplasia
    malignant mesothelioma    barrett's esophagus


    Find genes that share disorders with CTNNA1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CTNNA1 gene (see all 71)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 57.5 56 10461060 (4), 7629995 (4), 7565577 (4), 9624037 (3) (see all 27)
    colon carcinoma 55.9 20 8081881 (2), 9166410 (1), 18690644 (1), 9700171 (1) (see all 13)
    carcinoma 54.8 37 15948257 (2), 11554165 (2), 7887451 (2), 10709091 (2) (see all 24)
    carcinoma lobular 53.5 3 8188525 (1), 17143261 (1)
    tumors 52.6 122 16554911 (4), 17316610 (3), 9234707 (3), 17989230 (3) (see all 66)
    familial adenomatous polyposis 52.1 5 10207085 (1), 10681434 (1), 9024698 (1), 9110993 (1)
    cancer 42.9 47 17945508 (3), 10343606 (3), 19458087 (3), 11096236 (2) (see all 26)
    colon cancer 37.7 16 10896949 (2), 7629995 (2), 15051498 (2), 9809040 (1) (see all 10)
    gastric carcinoma 35.8 8 15948257 (4), 15133841 (1), 15128072 (1)
    bladder carcinoma 34.7 4 16413663 (2), 16554911 (2)

    Genetic Association Database (GAD): CTNNA1
    Human Genome Epidemiology (HuGE) Navigator: CTNNA1 (3 documents)

    Export disorders for CTNNA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTNNA1 gene, integrated from 10 sources (see all 532):
    (articles sorted by number of sources associating them with CTNNA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning reveals alternative splice forms of human alpha(E)- catenin. (PubMed id 7945318)1, 2, 9 Rimm D.L.... Morrow J.S. (Biochem. Biophys. Res. Commun. 1994)
    2. The uvomorulin-anchorage protein alpha catenin is a vinculin homologue. (PubMed id 1924379)1, 3, 9 Herrenknecht K....Kemler R. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    3. Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms. (PubMed id 21708131)1, 2 Kask M.... Timmusk T. (Biochem. Biophys. Res. Commun. 2011)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)1, 2 Beranova-Giorgianni S.... Giorgianni F. (Pituitary 2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Systematic identification and analysis of mammalian small ubiquitin- like modifier substrates. (PubMed id 15561718)1, 2 Gocke C.B.... Kang J. (J. Biol. Chem. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. (PubMed id 12417594)1, 2 Marie H.... Braga V.M. (J. Biol. Chem. 2003)
    10. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1495 HGNC: 2509 AceView: CTNNA1 Ensembl:ENSG00000044115 euGenes: HUgn1495
    ECgene: CTNNA1 Kegg: 1495 H-InvDB: CTNNA1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CTNNA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTNNA1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ctnna1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTNNA1 gene:
    Search GeneIP for patents involving CTNNA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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