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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTLA4 Gene

protein-coding   GIFtS: 64
GCID: GC02P204696

Cytotoxic T-Lymphocyte-Associated Protein 4

(Previous name: celiac disease 3)
(Previous symbol: CELIAC3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cytotoxic T-Lymphocyte-Associated Protein 41 2     GSE2
CELIAC31 2 5     CD152 Isoform2
Celiac Disease 31 2     Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form2
Cytotoxic T-Lymphocyte-Associated Antigen 42 3     Cytotoxic T-Lymphocyte Antigen 42
CD1522 3     Cytotoxic T-Lymphocyte Protein 42
CTLA-42 3     Cytotoxic T-Lymphocyte-Associated Serine Esterase-42
GRD42 5     Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen
42
IDDM122 5     CD152 Antigen3
CD2     

External Ids:    HGNC: 25051   Entrez Gene: 14932   Ensembl: ENSG000001635997   OMIM: 1238905   UniProtKB: P164103   

Export aliases for CTLA4 gene to outside databases

Previous GC identifers: GC02P202949 GC02P203457 GC02P204935 GC02P204558 GC02P204440 GC02P196580


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTLA4 Gene:
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal
to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate
transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform
functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer.
Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto
thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune
diseases. (provided by RefSeq, Jul 2008)

GeneCards Summary for CTLA4 Gene: 
CTLA4 (cytotoxic T-lymphocyte-associated protein 4) is a protein-coding gene. Diseases associated with CTLA4 include graves' disease, and celiac disease 3, and among its related super-pathways are Costimulation by the CD28 family and Immune System. GO annotations related to this gene include protein binding. An important paralog of this gene is CD28.

UniProtKB/Swiss-Prot: CTLA4_HUMAN, P16410
Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for
its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate
stimulatory coreceptor CD28

Gene Wiki entry for CTLA4 (CTLA-4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTLA4 gene promoter:
         AML1a   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTLA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CTLA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTLA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q33.2   HGNC cytogenetic band: 2q33

CTLA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTLA4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P204696:  view genomic region     (about GC identifiers)

Start:
204,732,509 bp from pter      End:
204,738,683 bp from pter
Size:
6,175 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CTLA4_HUMAN, P16410 (See protein sequence)
Recommended Name: Cytotoxic T-lymphocyte protein 4 precursor  
Size: 223 amino acids; 24656 Da
Subunit: Homodimer; disulfide-linked. Binds to CD80/B7-1 and CD86/B7.2
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Exists primarily an intracellular
antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid
internalisation;
6/7 PDB 3D structures from and Proteopedia for CTLA4 (see all 7):
1AH1 (3D)        1H6E (3D)        1I85 (3D)        1I8L (3D)        2X44 (3D)        3BX7 (3D)    
Secondary accessions: A0N1S0 E9PDH0 O95653 Q0PP65 Q52MC1 Q53TD5 Q5S005 Q8WXJ1 Q96P43 Q9UKN9
Alternative splicing: 5 isoforms:  P16410-1   P16410-2   P16410-3   P16410-4   P16410-5   

Explore the universe of human proteins at neXtProt for CTLA4: NX_P16410

Explore proteomics data for CTLA4 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylation is important for dimerization
  • UniProtKB: Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to
    retention of CTLA4 on the cell surface
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16410

  • CTLA4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CTLA4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001032720.1  NP_005205.2  

    ENSEMBL proteins: 
     ENSP00000303939   ENSP00000295854   ENSP00000417779   ENSP00000409707  
    Reactome Protein details: P16410
    Human Recombinant Protein Products for CTLA4: 
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    OriGene Protein Over-expression Lysate for CTLA4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CTLA4
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    Novus Biologicals CTLA4 Proteins
    Novus Biologicals CTLA4 Lysate
    Sino Biological Recombinant Protein for CTLA4
    Sino Biological Cell Lysate for CTLA4 
    ProSpec Recombinant Protein for CTLA4
    Cloud-Clone Corp. Proteins for CTLA4 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IDA15814706
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS3220103
    GO:0009897external side of plasma membrane IDA18641304
    GO:0045334clathrin-coated endocytic vesicle IDA15814706

    CTLA4 for ontologies           About GeneDecksing



    CTLA4 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR003596 Ig_V-set_subgr
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR008096 CTLA4

    Graphical View of Domain Structure for InterPro Entry P16410

    ProtoNet protein and cluster: P16410

    3 Blocks protein domains:
    IPB003596 Immunoglobulin V-type
    IPB003599 Immunoglobulin subtype
    IPB008096 Cytotoxic T-lymphocyte antigen 4 signature


    UniProtKB/Swiss-Prot: CTLA4_HUMAN, P16410
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CTLA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTLA4_HUMAN, P16410
    Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for
    its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate
    stimulatory coreceptor CD28

         Genatlas biochemistry entry for CTLA4:
    cytotoxic T-lymphocyte-associated granule serine protease 4,B7 costimulatory protein receptor for
    CD80,CD86,negative regulatory T cell presenting costimulatory molecule,member of the immunoglobulin
    superfamily,with an association of the exon 3 microsatellite,106bp allele with autoimmune disorders (conferring
    susceptibility to Graves disease and to thyroid associated orbitopathy but not to systemic lupus
    erythematosus),susceptibility gene for the celiac disease and for multiple sclerosis

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11279501
         
    CTLA4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CTLA4:
     Increased cell number in G1, a 

         14 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Ctla4):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     normal  pigmentation  respiratory system  skeleton 

    CTLA4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CTLA4: Ctla4tm1All Ctla4tm1Mak Ctla4tm1Shr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CTLA4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTLA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTLA4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTLA4 

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    miRTarBase miRNAs that target CTLA4:
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTLA4
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate CTLA4 (see all 14):
    hsa-miR-4324 hsa-miR-502-5p hsa-miR-4311 hsa-miR-3688-3p hsa-miR-4255 hsa-miR-496 hsa-miR-656 hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidCTLA4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTLA4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CTLA4 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1CD28 co-stimulation
    Costimulation by the CD28 family0.41
    CTLA4 Signaling0.31
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3PKC-Theta Pathway
    TCR Signaling0.68
    4ICos-ICosL Pathway in T-Helper Cell
    CD28 Signaling in T-Helper Cell0.66
    5Allograft rejection
    Autoimmune thyroid disease0.62

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CTLA4
        CTLA4 Signaling
    TCR Signaling
    CD28 Signaling in T-Helper Cell

    1 BioSystems Pathway for CTLA4
        Calcineurin-regulated NFAT-dependent transcription in lymphocytes


    4        Reactome Pathways for CTLA4
        Costimulation by the CD28 family
    Adaptive Immune System
    CTLA4 inhibitory signaling
    Immune System


    4         Kegg Pathways  (Kegg details for CTLA4):
        Cell adhesion molecules (CAMs)
    T cell receptor signaling pathway
    Autoimmune thyroid disease
    Rheumatoid arthritis


    CTLA4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTLA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/24 Interacting proteins for CTLA4 (P164101, 2, 3 ENSP000003039394) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R1P279862, 3, ENSP000002743354MINT-8035246 MINT-8035216 MINT-8035201 I2D: score=2 STRING: ENSP00000274335
    CD86P420811, 3, ENSP000003320494EBI-1030991,EBI-1030956 I2D: score=3 STRING: ENSP00000332049
    CD80P336811, 3, ENSP000002642464EBI-1030991,EBI-1031024 I2D: score=4 STRING: ENSP00000264246
    FYNP062413, ENSP000003576564I2D: score=4 STRING: ENSP00000357656
    LCKP062393, ENSP000003378254I2D: score=2 STRING: ENSP00000337825
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response IEA--
    GO:0006974response to DNA damage stimulus IMP17875758
    GO:0030889negative regulation of B cell proliferation IMP17875758
    GO:0031295T cell costimulation TAS--
    GO:0043065positive regulation of apoptotic process IMP17875758

    CTLA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CTLA4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTLA4

    UniProtKB/Swiss-Prot: CTLA4_HUMAN, P16410
    Pharmaceutical: Engineered fusion proteins consisting of the extracellular domain of CTLA4 and the IgG Fc region
    (Ctla4-Ig), inhibit T-cell-dependent antibody responses, and are used as immunosuppressive agents. They are
    soluble, have an enhanced affinity for B7 ligands and act as a competitive inhibitor of CD28

    1 DrugBank Compound for CTLA4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423

    10/50 Novoseek inferred chemical compound relationships for CTLA4 gene (see all 50)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mh-30 81.1 3 15841095 (1), 15316504 (1)
    abatacept 77.4 32 18050376 (2), 18718877 (1), 19243211 (1), 19259798 (1) (see all 13)
    ctla4-ig 74.7 17 8228824 (2), 17924973 (2), 7678111 (1), 7504299 (1) (see all 13)
    belatacept 63 3 16121705 (1), 20502720 (1)
    indoleamine 45.9 4 17981708 (1), 17715231 (1), 18816483 (1), 16493086 (1)
    il 10 42.3 7 15607008 (2), 15708894 (1), 18261221 (1), 18337305 (1) (see all 5)
    ionomycin 38.2 12 12444128 (3), 10600000 (2), 10777098 (1), 9857283 (1)
    tyrosine 27.9 60 9712716 (6), 9973379 (4), 10604992 (3), 10842319 (3) (see all 29)
    tgf beta1 21.3 6 19269255 (4), 19597336 (1), 16872485 (1)
    infliximab 18.8 1 19104936 (1)

    Search CenterWatch for drugs/clinical trials and news about CTLA4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for CTLA4 gene (2 alternative transcripts): 
    NM_001037631.2  NM_005214.4  

    Unigene Cluster for CTLA4:

    Cytotoxic T-lymphocyte-associated protein 4
    Hs.247824  [show with all ESTs]
    Unigene Representative Sequence: NM_005214
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302823(uc002vak.2 uc002val.2 uc010fty.2 uc010ftz.2)
    ENST00000295854 ENST00000487393 ENST00000472206 ENST00000427473
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTLA4

    Additional mRNA sequence: 

    AF414120.1 AF486806.1 AJ298052.1 AK313732.1 AY209009.1 AY792514.1 AY999702.1 BC069566.1 
    BC070162.1 BC074842.2 BC074893.2 DQ785106.1 L15006.1 U90273.1 

    5 DOTS entries:

    DT.40126443  DT.91756479  DT.95146339  DT.95133126  DT.99980295 

    22 AceView cDNA sequences:

    AW515943 BC074893 U90273 AF486806 AW207094 NM_005214 BG236211 AF414120 
    AI819438 BC074842 BG058720 AY209009 BC070162 CD639535 BC069566 L15006 
    BV183431 BM997840 BE837454 BG536887 AA210929 AI860199 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTLA4 expression in normal human tissues (normalized intensities)      CTLA4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAATATTT
    CTLA4 Expression
    About this image


    CTLA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 6 entries
             T Helper Cells Thymus
             Regulatory T cells
             Peripheral blood Pan-T Cells   
             cd4+ t cells   
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Lymph (Hematopoietic System)
             lymph node   
     
     Tonsil (Hematopoietic System)

    See CTLA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTLA4

    SOURCE GeneReport for Unigene cluster: Hs.247824

    UniProtKB/Swiss-Prot: CTLA4_HUMAN, P16410
    Tissue specificity: Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where
    expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following
    activation

        SABiosciences Expression via Pathway-Focused PCR Arrays including CTLA4: 
              Cell Surface Markers in human mouse rat
              Th1/Th2 Response in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Diabetes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CTLA4
    OriGene qSTAR qPCR primer pairs in human, mouse for CTLA4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTLA4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTLA4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTLA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTLA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CTLA4 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctla41 , 5 cytotoxic T-lymphocyte-associated protein 41, 5 79.97(n)1
    74.89(a)1
      1 (30.58 cM)5
    124771  NM_009843.31  NP_033973.21 
     608870005 
    chicken
    (Gallus gallus)
    Aves CTLA41 cytotoxic T-lymphocyte-associated protein 4 60.85(n)
    49.23(a)
      424106  NM_001040091.1  NP_001035180.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    34(a)
    31(a)
    many → 1
    many → 1
    AAWZ02040505(955-5793)
    GL343208.1(2684025-2687950)
    zebrafish
    (Danio rerio)
    Actinopterygii cd286
    CD28 molecule
    24(a)
    1 → many
    9(14262659-14265291)


    ENSEMBL Gene Tree for CTLA4 (if available)
    TreeFam Gene Tree for CTLA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTLA4 gene
    CD282  

    CTLA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CTLA4_HUMAN, P16410
    Polymorphism: Genetic variations in CTLA4 are associated with susceptibility to several autoimmune disorders. They
    influence responsiveness to hepatitis B virus (HBV) infection [MIM:610424]


    10/179 SNPs in CTLA4 are shown (see all 179)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2317751,2,4
    C,F,O,A,Hother1204122578(+) TGGCTA/GCCAGG 4 T A mis1 ese339Minor allele frequency- G:0.44EA NA MN NS CSA WA EU 11608
    rs358325611,2
    F--204120564(+) TGCTCA/GTCCCC 2 -- us2k15Minor allele frequency- G:0.01MN 404
    rs134101491,2
    C,H--204120624(+) CTTTAG/ACCCAT 2 -- us2k19Minor allele frequency- A:0.00NS EA MN 824
    rs1472677151,2
    --204120657(+) CCACCC/TTTTTC 2 -- us2k10--------
    rs7336191,2
    C,F,H--204120669(-) ATTGAG/CAACAG 2 -- us2k116Minor allele frequency- C:0.03NS EA NA MN CSA WA 1585
    rs360218101,2
    F--204120692(+) CTTTTC/TGTCTT 2 -- us2k15Minor allele frequency- T:0.01MN 404
    rs30872411,2
    C,H--204120755(+) TACATA/GATACT 2 -- us2k19Minor allele frequency- G:0.00MN NS EA 824
    rs115713151,2
    C,F,H--204120765(-) ctggaG/Attgaa 2 -- us2k130Minor allele frequency- A:0.48NS EA NA MN WA CSA 2732
    rs7336181,2
    C,F,A,H--204120808(-) GACAGA/GCAGCT 2 -- us2k121Minor allele frequency- G:0.17NS EA NA MN WA 2742
    rs45538081,2
    C,F,A,H--204120869(+) TTTTTA/GAAAAA 2 -- us2k114Minor allele frequency- G:0.15MN NS EA NA WA 1014

    HapMap Linkage Disequilibrium report for CTLA4 (204732509 - 204738683 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CTLA4: --

    Human Gene Mutation Database (HGMD): CTLA4
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CTLA4
    DNA2.0 Custom Variant and Variant Library Synthesis for CTLA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 123890   
    OMIM disorders: 140300  601388  609755  
    UniProtKB/Swiss-Prot: CTLA4_HUMAN, P16410
  • Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile
    multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints,
    kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory
    mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated
    erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Note=Genetic variations in CTLA4 may influence susceptibility to Graves disease, an autoimmune disorder
    associated with overactivity of the thyroid gland and hyperthyroidism
  • Diabetes mellitus, insulin-dependent, 12 (IDDM12) [MIM:601388]: A multifactorial disorder of glucose
    homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical
    features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and
    secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and
    blood vessels. Note=Disease susceptibility is associated with variations affecting the gene represented in this
    entry
  • Celiac disease 3 (CELIAC3) [MIM:609755]: A multifactorial, chronic disorder of the small intestine caused
    by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal
    absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat
    and rye induces a flat jejunal mucosa with infiltration of lymphocytes. Note=Disease susceptibility is associated
    with variations affecting the gene represented in this entry

  • 20/186 diseases for CTLA4 (see all 186):    About MalaCards
    graves' disease    celiac disease 3    paracoccidioidomycosis    celiac disease
    autoimmune hepatitis    wegener's granulomatosis    allergic encephalomyelitis    cd40 ligand deficiency
    diabetic ketoacidosis    autoimmune thyroiditis    diabetes mellitus    primary biliary cirrhosis
    myxedema    autoimmune myocarditis    type 1 diabetes mellitus    addison's disease
    blood disorders    hypothyroidism, autoimmune    type 1 diabetes    myasthenia gravis

    9 diseases from the University of Copenhagen DISEASES database for CTLA4:
    Hypersensitivity reaction type II disease     Melanoma     Hyperthyroidism     Thyroiditis
    Rheumatoid arthritis     Diabetes mellitus     Connective tissue disease     Multiple sclerosis
    Asthma

    CTLA4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/93 Novoseek inferred disease relationships for CTLA4 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune thyroid disease 84.6 60 9861324 (2), 12202150 (2), 17504905 (2), 19559744 (2) (see all 38)
    autoimmune diseases 84.2 258 18613834 (3), 10215771 (3), 15649153 (3), 9861324 (2) (see all 99)
    graves disease 82.3 122 19524188 (4), 15182328 (4), 10404810 (4), 9231050 (3) (see all 63)
    autoimmunity 80.1 83 19595177 (4), 15790353 (3), 16046318 (2), 19412189 (2) (see all 56)
    hashimotos thyroiditis 75.3 38 9398726 (4), 17020648 (3), 16611252 (2), 12225635 (2) (see all 16)
    genetic susceptibility 70.3 54 11752507 (2), 8989248 (2), 16405845 (2), 10619986 (1) (see all 35)
    metastatic melanoma 68.3 31 16283570 (2), 18528295 (2), 16490844 (2), 16615096 (2) (see all 22)
    cancer regression 64 5 12826605 (2), 16283570 (1), 18528295 (1)
    addisons disease 58.8 22 9398726 (4), 10197076 (3), 15240634 (2), 15621571 (1) (see all 9)
    diabetes mellitus insulin-dependent 55.4 37 10619986 (3), 15961581 (2), 15237707 (2), 19136037 (2) (see all 19)

    Genetic Association Database (GAD): CTLA4
    Human Genome Epidemiology (HuGE) Navigator: CTLA4 (525 documents)

    Export disorders for CTLA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTLA4 gene, integrated from 9 sources (see all 1496) (see top 10):
    (articles sorted by number of sources associating them with CTLA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta- analysis. (PubMed id 15688186)1, 2, 4, 9 Lee Y.H.... Nath S.K. (2005)
    2. Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus. (PubMed id 15138458)1, 2, 4, 9 Barreto M.... Vicente A.M. (2004)
    3. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. (PubMed id 9259273)1, 2, 4, 9 Marron M.P.... She J.-X. (1997)
    4. A common CTLA4 haplotype associated with coeliac disease. (PubMed id 15657618)1, 2, 4 Hunt K.A.... van Heel D.A. (2005)
    5. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. (PubMed id 12724780)1, 2, 4 Ueda H....Gough S.C. (2003)
    6. Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy. (PubMed id 10475192)1, 2, 4 Vaidya B.... Pearce S.H.S. (1999)
    7. CTLA-4 gene polymorphism is associated with predisposition to coeliac disease. (PubMed id 10189842)1, 2, 4 Djilali-Saiah I.... Caillat-Zucman S. (1998)
    8. Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. (PubMed id 3220103)1, 2, 3 Dariavach P.... Lefranc M.-P. (1988)
    9. Expression of CD152 (CTLA-4) in children with autoimm une thyroiditis and +49 A/G polymorphism of exon 1 of the CTLA-4 gene. (PubMed id 20134044)1, 4, 9 Kucharska A.M....Demkow U. (2009)
    10. CTLA4 is differentially associated with autoimmune diseases in the Dutch population. (PubMed id 16025348)1, 4, 9 Zhernakova A....Koeleman B.P. (2005)
    11. Polymorphsims of CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in spondyloarthropathies. (PubMed id 11771526)1, 4, 9 Lee Y.H....Song G.G. (2001)
    12. Influence of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) common polymorphisms on outcome in treatment of melanoma patients with CTLA-4 blockade. (PubMed id 18528295)1, 4, 9 Breunis W.B....Chanock S.J. (2008)
    13. [+49 A/G genetic polymorphism of cytotoxic T lymphocy te associated antigen 4 (CTLA-4) in type 7 diabetes: association with autoantib odies and cytokines] (PubMed id 19621172)1, 4, 9 PAcrez B F....Carrasco P E. (2009)
    14. Gender-limited association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphism with cord blood IgE levels. (PubMed id 15610363)1, 4, 9 Chang J.C....Yang K.D. (2004)
    15. Analysis of cytotoxic T lymphocyte antigen-4 (CTLA-4) exon 1 polymorphism in patients with type 1 diabetes mellitus in a Turkish population. (PubMed id 15237707)1, 4, 9 Genc S....Buyukgebiz A. (2004)
    16. Genomic regulation of CTLA4 and multiple sclerosis. (PubMed id 18691768)1, 4, 9 Palacios R....Villoslada P. (2008)
    17. Association of the CTLA-4 gene with rheumatoid arthritis in Chinese Han population. (PubMed id 15841095)1, 4, 9 Lei C....Daming R. (2005)
    18. Association of DRB1*04-DQB1*0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto's thyroiditis in an Italian population. (PubMed id 11288988)1, 4, 9 Petrone A....Buzzetti R. (2001)
    19. CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease. (PubMed id 11086105)1, 4, 9 Kouki T....DeGroot L.J. (2000)
    20. Functional polymorphism of cytotoxic T-lymphocyte ant igen 4 and nasopharyngeal carcinoma susceptibility in a Chinese population. (PubMed id 19922464)1, 4, 9 Xiao M....Tang J. (2010)
    21. The CTLA-4 gene polymorphisms are associated with CTL A-4 protein expression levels in multiple sclerosis patients and with susceptib ility to disease. (PubMed id 19740340)1, 4, 9 Karabon L....Frydecka I. (2009)
    22. CTLA4 gene polymorphisms and soluble CTLA4 protein in Behcet's disease. (PubMed id 19563524)1, 4, 9 Park K.S....Lee E.S. (2009)
    23. Functional polymorphism of CTLA-4 and ICOS genes in allogeneic hematopoietic stem cell transplantation. (PubMed id 19332044)1, 4, 9 Wu J....Yang Y.C. (2009)
    24. Recipient cytotoxic T lymphocyte antigen-4 +49 G/G genotype is associated with reduced incidence of hepatitis B virus recurrence after liver transplantation among Chinese patients. (PubMed id 17919231)1, 4, 9 Jiang Z....Zheng S. (2007)
    25. Association of Epstein-Barr virus with systemic lupus erythematosus: effect modification by race, age, and cytotoxic T lymphocyte-associated antigen 4 genotype. (PubMed id 15818712)1, 4, 9 Parks C.G....Pandey J.P. (2005)
    26. Cytotoxic T-lymphocyte antigen 4 gene polymorphisms in sarcoidosis patients. (PubMed id 15881277)1, 4, 9 Hattori N....Ueda R. (2005)
    27. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) exon 1 polymorphism affects lymphocyte profiles in bronchoalveolar lavage of patients with sarcoidosis. (PubMed id 14620161)1, 4, 9 Handa T....Mishima M. (2003)
    28. CTLA-4 gene polymorphism in promoter and exon-1 regions in Chinese patients with systemic lupus erythematosus. (PubMed id 11678454)1, 4, 9 Liu M.F....Wu C.R. (2001)
    29. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location. (PubMed id 1713603)1, 2, 9 Harper K....Golstein P. (1991)
    30. Combination of CTLA-4 and TGFbeta1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak. (PubMed id 19269255)1, 4, 9 Chen R.F....Yang K.D. (2009)
    31. Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. (PubMed id 19951419)1, 4, 9 Carr E.J....Smith K.G. (2009)
    32. [Association of CTLA-4 + 49A/G and CT60 gene polymorp hism with type 1 diabetes and thyroid autoimmunity] (PubMed id 19595177)1, 4, 9 Jin P....Zhou Z.G. (2009)
    33. Interactions between programmed death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) gene polymorphisms in type 1 diabetes. (PubMed id 19147248)1, 4, 9 Momin S....Perez-Bravo F. (2009)
    34. Association of CTLA-4 gene polymorphism with Graves' disease and ophthalmopathy in Iranian patients. (PubMed id 19524188)1, 4, 9 Esteghamati A....Amirzargar A. (2009)
    35. Functional genetic variations in cytotoxic T-lymphocyte antigen 4 and susceptibility to multiple types of cancer. (PubMed id 18757416)1, 4, 9 Sun T....Lin D. (2008)
    36. Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population. (PubMed id 17825114)1, 4, 9 Wang L....Li D. (2007)
    37. Characterization of CD28, CTLA4, and ICOS polymorphisms in three Brazilian ethnic groups. (PubMed id 16112024)1, 4, 9 Guzman V.B....Gerbase-Delima M. (2005)
    38. CTLA-4 gene polymorphism and its association with Graves' disease in the Lebanese population. (PubMed id 15182328)1, 4, 9 Nakkash-Chmaisse H....Salti I. (2004)
    39. Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with type 1 diabetes in the Japanese population. (PubMed id 11685455)1, 4, 9 Ihara K....Hara T. (2001)
    40. Clinical associations of the genetic variants of CTLA -4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease. (PubMed id 19438904)1, 4, 9 Gu L.Q....Zhao Y.J. (2010)
    41. CTLA4 gene variations and haplotypes in patients with lung cancer. (PubMed id 20082854)1, 4, 9 Khaghanzadeh N....Ghaderi A. (2010)
    42. [Interactions between susceptible genes and risk envi ronmental factors in Chinese females with systemic lupus erythematosus] (PubMed id 20388336)1, 4, 9 Peng C.L....Meng W. (2010)
    43. PDCD1, CTLA-4 and p53 gene polymorphism and susceptibility to gestational trophoblastic diseases. (PubMed id 19263877)1, 4, 9 Dehaghani A.S....Ghaderi A. (2009)
    44. Association between IL4 (-590), ACE (I)/(D), CCR5 (Delta32), CTLA4 (+49) and IL1-RN (VNTR in intron 2) gene polymorphisms and vitiligo. (PubMed id 19129082)1, 4, 9 Pehlivan S....Ozkinay C. (2009)
    45. Genetic polymorphisms of immunoregulatory proteins in acute renal allograft rejection. (PubMed id 19857736)1, 4, 9 Krichen H....Gorgi Y. (2009)
    46. CTLA4 gene polymorphisms in children and adolescents with autoimmune thyroid diseases. (PubMed id 18752454)1, 4, 9 Yesilkaya E....Cinaz P. (2008)
    47. Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population. (PubMed id 18396212)1, 4, 9 Suwalska K....Frydecka I. (2008)
    48. Distribution of CTLA-4 polymorphisms in allergic asthma. (PubMed id 16926542)1, 4, 9 Jasek M....Kusnierczyk P. (2006)
    49. [The frequency of CTLA-4 gene polymorphism at position 49 exon 1 in children with Hashimoto's thyroiditis] (PubMed id 17020648)1, 4, 9 Kucharska A....Rymkiewicz-Kluczynska B. (2006)
    50. Cytotoxic T lymphocyte antigen-4 promoter variants in breast cancer. (PubMed id 16527605)1, 4, 9 Erfani N....Ghaderi A. (2006)
    51. CTLA4 polymorphisms are associated with vitiligo, in patients with concomitant autoimmune diseases. (PubMed id 15649153)1, 4, 9 Blomhoff A....Undlien D.E. (2005)
    52. Ethnic differences in cytotoxic T lymphocyte associated antigen 4 genotype associations with systemic sclerosis. (PubMed id 14705224)1, 4, 9 Hudson L.L....Pandey J.P. (2004)
    53. Polymorphism of the immune-braking gene CTLA-4 (+49) involved in gender discrepancy of serum total IgE levels and allergic diseases. (PubMed id 14720259)1, 4, 9 Yang K.D....Wang C.L. (2004)
    54. Association of CTLA4 gene A-G polymorphism with rheumatoid arthritis in Chinese. (PubMed id 14505215)1, 4, 9 Lee C.S....Liu T.L. (2003)
    55. Association of CTLA-4 but not CD28 gene polymorphisms with systemic lupus erythematosus in the Japanese population. (PubMed id 11426024)1, 4, 9 Ahmed S....Hara T. (2001)
    56. Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4. (PubMed id 10842319)1, 2, 9 Chikuma S....Uede T. (2000)
    57. Study of the CTLA-4 gene polymorphisms in systemic lu pus erythematosus (SLE) samples from Malaysia. (PubMed id 19951233)1, 4, 9 Chua K.H....Lian L.H. (2010)
    58. Association of the CTLA4 gene with Graves' disease in the Chinese Han population. (PubMed id 20352109)1, 4, 9 Zhao S.X....Song H.D. (2010)
    59. Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis. (PubMed id 20113255)1, 4, 9 Kim Y.O....Hong S.J. (2010)
    60. Association of plasma soluble CTLA-4 with lung functi on and gene polymorphism in Chinese asthmatic children. (PubMed id 20016193)1, 4, 9 Chan I.H....Lam C.W. (2010)
    61. Functional polymorphism in CTLA4 gene influences the response to therapy with inhaled corticosteroids in Slovenian children with ato pic asthma. (PubMed id 19895365)1, 4, 9 Berce V. and Potocnik U. (2010)
    62. CTLA4 and generalized vitiligo: two genetic association studies and a meta-analysis of published data. (PubMed id 19175525)1, 4, 9 Birlea S.A....Spritz R.A. (2009)
    63. Association of genetic variation in inducible costimulator gene with outcome of kidney transplantation. (PubMed id 19202444)1, 4, 9 Haimila K....Partanen J. (2009)
    64. CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population. (PubMed id 19333938)1, 4, 9 Walker E.J....Siminovitch K.A. (2009)
    65. CTLA-4 gene polymorphism of exon 1(+49 A/G) in Turkis h systemic lupus erythematosus patients. (PubMed id 19602000)1, 4, 9 Ulker M....Terzioglu E. (2009)
    66. CTLA-4 promoter polymorphisms are associated with lat ent autoimmune diabetes in adults. (PubMed id 19735686)1, 4, 9 Douroudis K....Uibo R. (2009)
    67. Association of polymorphism at position 49 in exon 1 of the cytotoxic T-lymphocyte-associated factor 4 gene with Graves' disease ref ractory to medical treatment, but not with amiodarone-associated thyroid dysfun ction. (PubMed id 19731979)1, 4, 9 Kimura H....Sato K. (2009)
    68. Impact of polymorphisms of the major histocompatibili ty complex class II, interleukin-10, tumor necrosis factor-alpha and cytotoxic T-lymphocyte antigen-4 genes on inhibitor development in severe hemophilia A. (PubMed id 19817985)1, 4, 9 Pavlova A....Oldenburg J. (2009)
    69. [Susceptibility genetic variants in Hungarian morbus Crohn and ulcerative colitis patients] (PubMed id 19103559)1, 4, 9 Magyari L. and Melegh B. (2009)
    70. CTLA4 exon 1 and promoter polymorphisms in patients w ith multiple sclerosis. (PubMed id 19737153)1, 4, 9 Yousefipour G....Ghaderi A. (2009)
    71. [Association of polymorphism of proteintyrosine phosphatase nonreceptor-22 gene with AITD.] (PubMed id 18687223)1, 4, 9 Yu Z.Y....Dong B.N. (2008)
    72. PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not. (PubMed id 18200060)1, 4, 9 LaBerge G.S....Spritz R.A. (2008)
    73. Distribution of the CTLA-4 single nucleotide polymorphisms CT60G>A and +49A>G in psoriasis vulgaris patients and control individuals from a Polish Caucasian population. (PubMed id 18093182)1, 4, 9 L/uszczek W....Kusnierczyk P. (2008)
    74. Frequency of concurrent autoimmune disorders in patients with autoimmune hepatitis: effect of age, gender, and genetic background. (PubMed id 18223493)1, 4, 9 Bittencourt P.L....Carrilho F.J. (2008)
    75. Increased frequency of the CTLA-4 49 A/G polymorphism in patients with acquired haemophilia A compared to healthy controls. (PubMed id 18081831)1, 4, 9 Pavlova A....Oldenburg J. (2008)
    76. Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking. (PubMed id 18462498)1, 4, 9 Costenbader K.H....Karlson E.W. (2008)
    77. Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: no association in patients from Germany, Hungary and Poland. (PubMed id 17942509)1, 4, 9 Greve B....Weissert R. (2008)
    78. CTLA4 gene polymorphisms and multiple sclerosis in Northern Ireland. (PubMed id 17524498)1, 4, 9 Heggarty S....Vandenbroeck K. (2007)
    79. Susceptible alleles of the CD40 and CTLA-4 genes are not associated with the relapse after antithyroid withdrawal in Graves' disease. (PubMed id 17949264)1, 4, 9 Kim K.W....Cho B.Y. (2007)
    80. CTLA-4 +49A/G and CT60 gene polymorphisms in primary Sjogren syndrome. (PubMed id 17341301)1, 4, 9 Gottenberg J.E....Miceli-Richard C. (2007)
    81. Interaction of maternal atopy, CTLA-4 gene polymorphism and gender on antenatal immunoglobulin E production. (PubMed id 17456215)1, 4, 9 Yang K.D....Huang E.Y. (2007)
    82. No evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: a meta-analysis. (PubMed id 17439880)1, 4, 9 Bagos P.G....Hamodrakas S.J. (2007)
    83. CTLA-4 gene exon-1 +49 A/G polymorphism: lack of association with autoimmune disease in patients with common variable immune deficiency. (PubMed id 17192819)1, 4, 9 Knight A.K....Cunningham-Rundles C. (2007)
    84. No evidence of a significant role for CTLA-4 in multiple sclerosis. (PubMed id 16325273)1, 4, 9 Roxburgh R.H....Compston A. (2006)
    85. CTLA4 polymorphisms and ophthalmopathy in Graves' disease patients: association study and meta-analysis. (PubMed id 16916658)1, 4, 9 Han S....Mao Y. (2006)
    86. Evidence for unique association signals in SLE at the CD28-CTLA4-ICOS locus in a family-based study. (PubMed id 17000707)1, 4, 9 Graham D.S....Vyse T.J. (2006)
    87. [A/G polymorphism at position 49 in exon 1 of CTLA-4 gene in Chinese women with unexplained recurrent spontaneous abortion] (PubMed id 16640877)1, 4, 9 Wang X.P....Lu P.H. (2006)
    88. Association of Graves' disease and Graves' ophthalmopathy with the polymorphisms in promoter and exon 1 of cytotoxic T lymphocyte associated antigen-4 gene. (PubMed id 17048303)1, 4, 9 Zhang Q....Lv X.Y. (2006)
    89. The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan. (PubMed id 16352685)1, 4, 9 Ikegami H....Ogihara T. (2006)
    90. [Cytotoxic T lymphocyte antigen-4 promoter gene polymorphism is significantly associated with ulcerative colitis] (PubMed id 16831326)1, 4, 9 Zhou F....Cheng H. (2006)
    91. CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE Review and meta-analysis. (PubMed id 15961581)1, 4, 9 Kavvoura F.K. and Ioannidis J.P. (2005)
    92. Association of the A/G polymorphism at position 49 in exon 1 of CTLA-4 with the susceptibility to unexplained recurrent spontaneous abortion in the Chinese population. (PubMed id 15790344)1, 4, 9 Wang X....Lu P. (2005)
    93. Immune response gene polymorphisms in renal transplant recipients. (PubMed id 16378074)1, 4, 9 Dmitrienko S....Keown P.A. (2005)
    94. Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese. (PubMed id 16015687)1, 4, 9 Machida H....Kohno S. (2005)
    95. CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in Japanese. (PubMed id 15652423)1, 4, 9 Fukazawa T....Sasaki H. (2005)
    96. Association of HLA-DR, -DQ genotype and CTLA-4 gene polymorphism with Graves' disease in Japanese children. (PubMed id 15640608)1, 4, 9 Iwama S....Sugihara S. (2005)
    97. [Association of CTLA-4 promoter -1722 polymorphism with systemic lupus erythematosus in Chinese] (PubMed id 15485777)1, 4, 9 Xu A.P....Su X.Y. (2004)
    98. CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States. (PubMed id 15540511)1, 4, 9 Parks C.G....Pandey J.P. (2004)
    99. Association of the CT60 marker of the CTLA4 gene with systemic lupus erythematosus. (PubMed id 15248219)1, 4, 9 Torres B....Gonzalez-Escribano M.F. (2004)
    100. Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population. (PubMed id 15378793)1, 4, 9 Fan L.Y....Zhong R.Q. (2004)
    101. CTLA4 gene and Graves' disease: association of Graves' disease with the CTLA4 exon 1 and intron 1 polymorphisms, but not with the promoter polymorphism. (PubMed id 12780750)1, 4, 9 Vaidya B....Pearce S.H. (2003)
    102. Exon-1 polymorphism of ctla-4 gene in Iranian patients with Graves' disease. (PubMed id 14567561)1, 4, 9 Kalantari T....Ghaderi A. (2003)
    103. CTLA4 polymorphism in Spanish patients with systemic lupus erythematosus. (PubMed id 14522090)1, 4, 9 Aguilar F....Gonzalez-Escribano M.F. (2003)
    104. CTLA-4 +49 A/G dimorphism in Italian patients with celiac disease. (PubMed id 12559633)1, 4, 9 Mora B....Mazzilli M.C. (2003)
    105. The study of CTLA-4 and vitamin D receptor polymorphisms in the Romanian type 1 diabetes population. (PubMed id 12003670)1, 4, 9 Guja C....Ionescu-Tirgoviste C. (2002)
    106. An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies. (PubMed id 11886967)1, 4, 9 Vaidya B....Young-Min S. (2002)
    107. CTLA-4 gene A/G polymorphism associated with diabetes mellitus in Han Chinese. (PubMed id 12515273)1, 4, 9 Ma Y....Yan W. (2002)
    108. Cytotoxic T-lymphocyte antigen-4 gene polymorphisms and human T-cell lymphotrophic virus-1 infection: their associations with Hashimoto's thyroiditis in Japanese patients. (PubMed id 12225635)1, 4, 9 Tomoyose T....Takasu N. (2002)
    109. Association of CTLA-4 with systemic sclerosis in Japanese patients. (PubMed id 12508774)1, 4, 9 Takeuchi F....Tanimoto K. (2002)
    110. Association of the CTLA4 3' untranslated region polymorphism with the susceptibility to rheumatoid arthritis. (PubMed id 11916172)1, 4, 9 Rodriguez M.R....Gonzalez-Escribano M.F. (2002)
    111. No association of polymorphisms of the CTLA-4 exon 1(+49) and promoter(-318) genes with rheumatoid arthritis in the Korean population. (PubMed id 12455815)1, 4, 9 Lee Y.H....Song G.G. (2002)
    112. Relation of three polymorphisms of the CTLA-4 gene in patients with Graves' disease. (PubMed id 11936461)1, 4, 9 Kouki T....Degroot L.J. (2002)
    113. HLA-DQB1 CAR1/CAR2, TNFa IR2/IR4 and CTLA-4 polymorphisms in Tunisian patients with rheumatoid arthritis and Sjogren's syndrome. (PubMed id 11752507)1, 4, 9 Hadj Kacem H....Ayadi H. (2001)
    114. CTLA4 in multiple sclerosis. Lack of genetic association in a European Caucasian population but evidence of interaction with HLA-DR2 among Shanghai Chinese. (PubMed id 11239948)1, 4, 9 Rasmussen H.B....Clausen J. (2001)
    115. Polymorphisms of the CTLA-4 exon 1 and promoter gene in systemic lupus erythematosus. (PubMed id 11678447)1, 4, 9 Lee Y.H....Song G.G. (2001)
    116. The codon 17 polymorphism of the CTLA4 gene in type 2 diabetes mellitus. (PubMed id 11158025)1, 4, 9 Rau H....Badenhoop K. (2001)
    117. Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. (PubMed id 11279501)1, 2, 9 Schwartz J.C....Almo S.C. (2001)
    118. Complex association analysis of Graves disease using a set of polymorphic markers. (PubMed id 10924276)1, 2, 9 Chistyakov D.A.... Nosikov V.V. (2000)
    119. CTLA-4 gene polymorphism in Japanese patients with rheumatoid arthritis. (PubMed id 11128657)1, 4, 9 Yanagawa T....Inada S. (2000)
    120. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. (PubMed id 8817351)1, 4, 9 Nistico L....Todd J.A. (1996)
    121. Polymorphisms of cytotoxic T lymphocyte-associated an tigen-4 and cytokine genes in Taiwanese patients with ankylosing spondylitis. (PubMed id 20030788)1, 4, 9 Lee W.Y....Shiau M.Y. (2010)
    122. The +49A>G CTLA-4 polymorphism is associated with rheumatoid arthritis in Mexican population. (PubMed id 20138855)1, 4, 9 MuA+oz-Valle J.F....Pereira-SuA!rez A.L. (2010)
    123. +49G > A polymorphism in the cytotoxic T-lymphocyt e antigen-4 gene increases susceptibility to hepatitis B-related hepatocellular carcinoma in a male Chinese population. (PubMed id 19778566)1, 4, 9 Gu X....Gao C. (2010)
    124. Influence of CTLA-4/CD28/ICOS gene polymorphisms on t he susceptibility to cervical squamous cell carcinoma and stage of differentiat ion in the Polish population. (PubMed id 19913589)1, 4, 9 Pawlak E....Frydecka I. (2010)
    125. HLA and CTLA4 polymorphisms may confer a synergistic risk in the susceptibility to Graves' disease. (PubMed id 20300120)1, 4, 9 Takahashi M. and Kimura A. (2010)
    126. CTLA-4 +49A>G polymorphism is associated with the risk but not with the progression of colorectal cancer in Chinese. (PubMed id 19787358)1, 4, 9 Qi P....Gao C.F. (2010)
    127. Interaction of immunological genes on chromosome 2q33 and IFNG in susceptibility to cervical cancer. (PubMed id 19959217)1, 4, 9 Ivansson E.L....Gyllensten U.B. (2010)
    128. Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis. (PubMed id 20072139)1, 4, 9 Hinks A....Thomson W. (2010)
    129. A haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis. (PubMed id 19222422)1, 4, 9 Benson M....Cardell L.O. (2009)
    130. The association of CTLA-4 and CD28 gene polymorphisms with idiopathic ischemic stroke in the paediatric population. (PubMed id 19284445)1, 4, 9 Wang J.J....Zou L.P. (2009)
    131. CTLA4 gene polymorphisms are associated with chronic bronchitis. (PubMed id 19386687)1, 4, 9 Zhu G....Pillai S.G. (2009)
    132. Soluble CTLA-4 receptor an immunological marker of Gr aves' disease and severity of ophthalmopathy is associated with CTLA-4 Jo31 and CT60 gene polymorphisms. (PubMed id 19734241)1, 4, 9 Daroszewski J....Bolanowski M. (2009)
    133. CTLA4 autoimmunity-associated genotype contributes to severe pulmonary tuberculosis in an African population. (PubMed id 19609446)1, 4, 9 Thye T....Horstmann R.D. (2009)
    134. Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort. (PubMed id 19180256)1, 4, 9 Martin T.M....Wallace G.R. (2009)
    135. Cytotoxic T-lymphocyte antigen 4 gene polymorphisms are associated with latent autoimmune diabetes in adults. (PubMed id 19332045)1, 4, 9 Douroudis K....Uibo R. (2009)
    136. CTLA-4 CT60 polymorphism in thyroid and polyglandular autoimmunity. (PubMed id 19530270)1, 4, 9 Dultz G....Kahaly G.J. (2009)
    137. CTLA-4 genotype and relapse incidence in patients with acute myeloid leukemia in first complete remission after induction chemotherapy. (PubMed id 19092854)1, 4, 9 PAcrez-GarcA-a A....Gallardo D. (2009)
    138. [Association of cytotoxic T lymphocyte antigen-4 prom oter C-658T polymorphism with ulcerative colitis in Chinese] (PubMed id 20017310)1, 4, 9 Luo Y....Jiang T. (2009)
    139. Association of CTLA-4 polymorphisms and clinical-immunologic characteristics at onset of type 1 diabetes mellitus in children. (PubMed id 19136037)1, 4, 9 Balic I....PAcrez-Bravo F. (2009)
    140. No association of CTLA-4 polymorphisms with susceptib ility to BehAset disease. (PubMed id 19570770)1, 4, 9 Du L....Kijlstra A. (2009)
    141. Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates. (PubMed id 19376178)1, 4, 9 Douroudis K....Kisand K. (2009)
    142. The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 diabetes mellitus in the Portuguese population. (PubMed id 19490216)1, 4, 9 Lemos M.C....Carvalheiro M. (2009)
    143. [Polymorphisms in inflammatory response genes in meta static renal cancer] (PubMed id 19658300)1, 4, 9 SA!enz LA^pez P....CA^zar Olmo J.M. (2009)
    144. Cytotoxic T lymphocyte antigen-4 promoter -658CT gene polymorphism is associated with ulcerative colitis in Chinese patients. (PubMed id 19089435)1, 4, 9 Luo Y....Zhao Y. (2009)
    145. [Genetic predisposition to multiple sclerosis as a po lygenic autoimmune disease] (PubMed id 19894308)1, 4, 9 Favorova O.O....Ochs M.F. (2009)
    146. Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis. (PubMed id 19404967)1, 4, 9 Daha N.A....Toes R.E. (2009)
    147. 49A/G and CT60 polymorphisms of the cytotoxic T-lymph ocyte-associated antigen 4 gene associated with autoimmune thyroid disease. (PubMed id 19559744)1, 4, 9 Bicek A....Hojker S. (2009)
    148. Cytotoxic T lymphocyte-associated molecule-4 polymorphism in Turkish patients with Hashimoto thyroiditis. (PubMed id 19284444)1, 4, 9 Sahin M....Erdogan M.F. (2009)
    149. Influence of CTLA-4 gene polymorphism in autoimmune and infectious diseases. (PubMed id 19345707)1, 4, 9 FernA!ndez-Mestre M....Layrisse Z. (2009)
    150. CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women. (PubMed id 18076363)1, 4, 9 Jaaskelainen E....Heinonen S. (2008)
    151. CTLA-4 gene polymorphisms predispose to autoimmune endocrinopathies but not to celiac disease. (PubMed id 18580850)1, 4, 9 Dallos T....Kovacs L. (2008)
    152. Immunoregulatory gene polymorphisms are associated with ANCA-related vasculitis. (PubMed id 18448390)1, 4, 9 Slot M.C....Cohen Tervaert J.W. (2008)
    153. Graves' disease in Brazilian children and adults: lack of genetic association with CTLA-4 +49A>G polymorphism. (PubMed id 18493148)1, 4, 9 Namo Cury A....Monte O. (2008)
    154. Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis. (PubMed id 18595775)1, 2, 9 Gu M....Wang X. (2008)
    155. CTLA-4 and multiple sclerosis: the A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population. (PubMed id 18378005)1, 4, 9 Wray B.N....McMorran B.J. (2008)
    156. Evaluation of functional single nucleotide polymorphisms of different genes coding for the immunoregulatory molecules in patients with monoclonal large granular lymphocyte lymphocytosis. (PubMed id 18361934)1, 4, 9 Garrido P....Ruiz-Cabello F. (2008)
    157. Primary biliary cirrhosis is associated with a genetic variant in the 3' flanking region of the CTLA4 gene. (PubMed id 18778710)1, 4, 9 Juran B.D....Lazaridis K.N. (2008)
    158. Interacting alleles of the coinhibitory immunoreceptor genes cytotoxic T-lymphocyte antigen 4 and programmed cell-death 1 influence risk and features of primary biliary cirrhosis. (PubMed id 18041714)1, 4, 9 Juran B.D....Lazaridis K.N. (2008)
    159. Family-based association study of cytotoxic T-lymphocyte antigen-4 with susceptibility to Graves' disease in Han population of Taiwan. (PubMed id 18059468)1, 4, 9 Chen P.L....Chang T.C. (2008)
    160. CTLA-4 polymorphisms are not associated with ocular inflammatory disease. (PubMed id 18498289)1, 4, 9 Bye L....Wallace G.R. (2008)
    161. Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms. (PubMed id 19014504)1, 4, 9 Berry A....Oaks M.K. (2008)
    162. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PubMed id 18174230)1, 4, 9 Miyagawa H....Horiuchi T. (2008)
    163. Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children. (PubMed id 18782261)1, 4, 9 Wallden J....Vaarala O. (2008)
    164. Influence of the TSH receptor gene on susceptibility to Graves' disease and Graves' ophthalmopathy. (PubMed id 18925838)1, 4, 9 Yin X....Davies T.F. (2008)
    165. Association of CTLA-4 and IL-13 gene polymorphisms with Graves' disease and ophthalmopathy in Chinese children. (PubMed id 18296657)1, 4, 9 Chong K.K....Pang C.P. (2008)
    166. Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis. (PubMed id 18576317)1, 4, 9 Prahalad S....Bamshad M.J. (2008)
    167. Two SNPs in the promoter region of the CTLA-4 gene affect binding of transcription factors and are associated with human myasthenia gravis. (PubMed id 18088253)1, 4, 9 Wang X.B....Lefvert A.K. (2008)
    168. A common CTLA4 polymorphism confers susceptibility to Autoimmune Thyroid Disease in celiac children. (PubMed id 18929517)1, 4, 9 Tolone C....Del Giudice E.M. (2008)
    169. New approach reveals CD28 and IFNG gene interaction in the susceptibility to cervical cancer. (PubMed id 18337305)1, 4, 9 Guzman V.B....Morgun A. (2008)
    170. Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese. (PubMed id 18371160)1, 4, 9 Umemura T....Kiyosawa K. (2008)
    171. Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children. (PubMed id 17469155)1, 4, 9 Sohn M.H....Kim K.E. (2007)
    172. Association of -318 C/T and +49 A/G cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms with a clinical subset of Italian patients with systemic sclerosis. (PubMed id 17459075)1, 4, 9 Balbi G....Pistillo M.P. (2007)
    173. A suggestive association of fuchs heterochromic cyclitis with cytotoxic T cell antigen 4 gene polymorphism. (PubMed id 17287608)1, 4, 9 Spriewald B.M....Wenkel H. (2007)
    174. T-cell regulatory gene CTLA-4 polymorphism/haplotype association with autoimmune pancreatitis. (PubMed id 17712006)1, 4, 9 Chang M.C....Wong J.M. (2007)
    175. Cytotoxic T-lymphocyte-associated antigen-4 single nucleotide polymorphisms and haplotypes in primary biliary cirrhosis. (PubMed id 17482523)1, 4, 9 Donaldson P....Bassendine M. (2007)
    176. High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer. (PubMed id 17678726)1, 4, 9 Cozar J.M....Ruiz-Cabello F. (2007)
    177. Analysis of CD28 and CTLA-4 gene polymorphisms in Turkish patients with Behcet's disease. (PubMed id 17284227)1, 4, 9 Gunesacar R....Ozbalkan Z. (2007)
    178. The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children. (PubMed id 17659059)1, 4, 9 Jonson C.O....Faresjo M. (2007)
    179. Association of CTLA4 single nucleotide polymorphisms with viral but not autoimmune liver disease. (PubMed id 18049163)1, 4, 9 Schott E....Berg T. (2007)
    180. Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis. (PubMed id 17504905)1, 4, 9 Kavvoura F.K....Ioannidis J.P. (2007)
    181. Susceptibility genes in Graves' ophthalmopathy: searching for a needle in a haystack? (PubMed id 17521325)1, 4, 9 Bednarczuk T....Wall J.R. (2007)
    182. No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples. (PubMed id 17465502)1, 4, 9 Magyari L....Melegh B. (2007)
    183. Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection. (PubMed id 17150279)1, 4, 9 Schott E....Berg T. (2007)
    184. A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene. (PubMed id 17334650)1, 4, 9 Howson J.M....Todd J.A. (2007)
    185. Ctla-4 exon 1 (+49) and promoter (-318) gene polymorphisms in kidney transplantation. (PubMed id 16980072)1, 4, 9 Gorgi Y....Ayed K. (2006)
    186. Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. (PubMed id 16750991)1, 4, 9 Maier L.M....Strachan D.P. (2006)
    187. Haplotypes in the CTLA4 region are associated with coeliac disease in the Irish population. (PubMed id 16237465)1, 4, 9 Brophy K....McManus R. (2006)
    188. CTLA-4 gene polymorphisms and natural soluble CTLA-4 protein in psoriasis vulgaris. (PubMed id 16712655)1, 4, 9 Luszczek W....Kusnierczyk P. (2006)
    189. The CTLA4+49A/G and CT60 polymorphisms and chronic inflammatory arthropathies in Northern Ireland. (PubMed id 16248997)1, 4, 9 Suppiah V....Vandenbroeck K. (2006)
    190. Association of CTLA-4 gene microsatellite polymorphism with ulcerative colitis in Chinese patients. (PubMed id 16670525)1, 4, 9 Jiang Y....Wong B.C. (2006)
    191. Genetics of type 1 diabetes: similarities and differences between Asian and Caucasian populations. (PubMed id 17130532)1, 4, 9 Ikegami H....Ogihara T. (2006)
    192. Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to chronic hepatitis B. (PubMed id 16489681)1, 4, 9 Mohammad Alizadeh A.H....Mousavi S.M. (2006)
    193. A comprehensive candidate gene study on bronchial asthma and juvenile idiopathic arthritis. (PubMed id 16788246)1, 4, 9 Schubert K....Heinzmann A. (2006)
    194. The association of CTLA-4 and HLA class II autoimmune risk genotype with regulatory T cell marker expression in 5-year-old children. (PubMed id 16792673)1, 4, 9 Jonson C.O....Vaarala O. (2006)
    195. The predictive value of CTLA-4 and Tg polymorphisms in the recurrence of Graves' disease after antithyroid withdrawal. (PubMed id 17526951)1, 4, 9 Tanrikulu S....Tezelman S. (2006)
    196. Risk of celiac disease in children with type 1 diabetes is modified by positivity for HLA-DQB1*02-DQA1*05 and TNF -308A. (PubMed id 16567828)1, 4, 9 Sumnik Z....Schober E. (2006)
    197. Thyroid autoantibody production is influenced by exon 1 and promoter CTLA-4 polymorphisms in patients with Hashimoto's thyroiditis. (PubMed id 16611252)1, 4, 9 Zaletel K....Hojker S. (2006)
    198. Three allele combinations associated with multiple sclerosis. (PubMed id 16872485)1, 4, 9 Favorova O.O....Ochs M.F. (2006)
    199. Polymorphisms within the CTLA4 gene are associated with infant atopic dermatitis. (PubMed id 16445777)1, 4, 9 Jones G....Stewart G. (2006)
    200. Association of polymorphisms in CTLA-4, IL-1ra and IL-1beta genes with multiple sclerosis in Serbian population. (PubMed id 16769128)1, 4, 9 Dincic E....Raicevic R. (2006)
    201. Exon-1 polymorphism of ctla-4 gene is not associated with systemic sclerosis in Iranian patients. (PubMed id 16189655)1, 4, 9 Rajaee A....Ghaderi A. (2006)
    202. Possible association of cytotoxic T lymphocyte antigen-4 genetic polymorphism with liver damage of primary biliary cirrhosis in Japan. (PubMed id 17427759)1, 4, 9 Kanno Y....Ohira H. (2006)
    203. Association of CTLA-4 gene promoter polymorphisms with systemic sclerosis in Iranian population. (PubMed id 16775619)1, 4, 9 Almasi S....Ghaderi A. (2006)
    204. The common -318C/T polymorphism in the promoter region of CTLA4 gene is associated with reduced risk of ophthalmopathy in Chinese Graves' patients. (PubMed id 16893393)1, 4, 9 Han S.Z....Li Y. (2006)
    205. Analysis of cytotoxic T lymphocyte associated antigen 4 gene polymorphisms in patients with ulcerative colitis. (PubMed id 16509873)1, 4, 9 Lankarani K.B....Ghaderi A. (2006)
    206. [The research on associating the single nucleotide polymorphism of CTLA-4 gene promoter region with idiopathic dilated cardiomyopathy] (PubMed id 16604497)1, 4, 9 Liu W....Kong Y.H. (2006)
    207. Risk of adverse post-transplant events after kidney allograft transplantation as predicted by CTLA-4 +49 and TNF-alpha -308 single nucleotide polymorphisms: a preliminary study. (PubMed id 17138053)1, 4, 9 Gendzekhadze K....Montano R.F. (2006)
    208. Association of CTLA-4 gene polymorphism with oral squamous cell carcinoma. (PubMed id 16393254)1, 4, 9 Wong Y.K....Liu C.J. (2006)
    209. Lack of a genetic association between the CTLA-4 gene and Graves' disease in Koreans. (PubMed id 16571085)1, 4, 9 Cho H.J....Kim J.W. (2006)
    210. Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin D receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related type 1 diabetes in the Japanese. (PubMed id 17130562)1, 4, 9 Kanazawa Y....Shimada A. (2006)
    211. CT60 single nucleotide polymorphism of the CTLA-4 gene is associated with susceptibility to Graves' disease in the Taiwanese population. (PubMed id 16081581)1, 4, 9 Weng Y.C....Lin W.S. (2005)
    212. Association of non-HLA genes with type 1 diabetes autoimmunity. (PubMed id 16046318)1, 4, 9 Steck A.K....Rewers M.J. (2005)
    213. Genetic interaction among three genomic regions creates distinct contributions to early- and late-onset type 1 diabetes mellitus. (PubMed id 16390390)1, 4, 9 Felner E.I....White P.C. (2005)
    214. [Relationship of CTLA-4 exon 1 A49-->G polymorphism with sCTLA-4 and Th1/Th2 bias in idiopathic dilated cardiomyopathy] (PubMed id 16405845)1, 4, 9 Liu W....Sun N.L. (2005)
    215. Association of a CTLA-4 3' untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population. (PubMed id 16040335)1, 4, 9 Ban Y....Ban Y. (2005)
    216. Heterozygosity in CTLA-4 gene and severe preeclampsia. (PubMed id 15617700)1, 4, 9 Samsami Dehaghani A....Ghaderi A. (2005)
    217. CT60 single nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen-4 gene region is associated with Graves' disease in an Italian population. (PubMed id 15785242)1, 4, 9 Petrone A....Buzzetti R. (2005)
    218. Polymorphisms at +49A/G and CT60 sites in the 3' UTR of the CTLA-4 gene and APECED-related AIRE gene mutations analysis in sporadic idiopathic hypoparathyroidism. (PubMed id 16313305)1, 4, 9 Goswami R....Vupputuri M.R. (2005)
    219. Cytotoxic T lymphocyte antigen 4 polymorphism 49 (A>G) and migraine. (PubMed id 16362660)1, 4, 9 Lulli P....Martelletti P. (2005)
    220. Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. (PubMed id 16380915)1, 4, 9 Plenge R.M....Rioux J.D. (2005)
    221. CTLA4/CT60 polymorphism is not relevant in susceptibility to autoimmune inflammatory intestinal disorders. (PubMed id 15784471)1, 4, 9 Rueda B....Martin J. (2005)
    222. Cytotoxic T lymphocyte-associated molecule-4 polymorphisms in Turkish Graves' disease patients and association with probability of remission after antithyroid therapy. (PubMed id 16137550)1, 4, 9 Sahin M....Erdogan G. (2005)
    223. CTLA4 gene polymorphism in Italian patients with colorectal adenoma and cancer. (PubMed id 15888281)1, 4, 9 Solerio E....Rosina F. (2005)
    224. Variants of the CTLA4 gene that segregate with autoimmune diseases are not associated with endometriosis. (PubMed id 16373368)1, 4, 9 Vigano P....Di Blasio A.M. (2005)
    225. CTLA-4 gene polymorphisms in Chinese patients with ulcerative colitis. (PubMed id 15973119)1, 4, 9 Hou W....Mao L. (2005)
    226. CTLA-4 +49 A/G polymorphism is associated with predisposition to type 1 diabetes in Iranians. (PubMed id 15860238)1, 4, 9 Mojtahedi Z....Ghaderi A. (2005)
    227. The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity. (PubMed id 16025255)1, 4, 9 Hermann R....Ilonen J. (2005)
    228. Distinct tumour necrosis factor alpha, interferon gamma, interleukin 10, and cytotoxic T cell antigen 4 gene polymorphisms in disease occurrence and end stage renal disease in Wegener's granulomatosis. (PubMed id 15708894)1, 4, 9 Spriewald B.M....Kalden J.R. (2005)
    229. Haplotype tagging efficiency in worldwide populations in CTLA4 gene. (PubMed id 16034471)1, 4, 9 Ramirez-Soriano A....Comas D. (2005)
    230. The polymorphisms -318C>T in the promoter and 49A>G in exon 1 of CTLA4 and the risk of aplastic anemia in a Caucasian population. (PubMed id 15812539)1, 4, 9 Svahn J....Iolascon A. (2005)
    231. Cytotoxic T lymphocyte antigen 4 heterozygous codon 49 A/G dimorphism is associated to latent autoimmune diabetes in adults (LADA). (PubMed id 16206510)1, 4, 9 Caputo M....Frechtel G.D. (2005)
    232. CTLA-4 gene 49A/G polymorphism in Turkish patients with Behcet's disease. (PubMed id 16045690)1, 4, 9 Sallakci N....Yegin O. (2005)
    233. Haplotype analysis in simplex families and novel analytic approaches in a case-control cohort reveal no evidence of association of the CTLA-4 gene with rheumatoid arthritis. (PubMed id 15022315)1, 4, 9 Barton A....Worthington J. (2004)
    234. A CTLA-4 polymorphism associated with susceptibility to systemic lupus erythematosus. (PubMed id 14730632)1, 4, 9 Fernandez-Blanco L....Gonzalez A. (2004)
    235. An analysis of CTLA-4 and proinflammatory cytokine genes in Wegener's granulomatosis. (PubMed id 15334480)1, 4, 9 Zhou Y....Hoffman G.S. (2004)
    236. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene polymorphism and susceptibility to non-Hodgkin's lymphoma. (PubMed id 15114591)1, 4, 9 Monne M....Gabbas A. (2004)
    237. No evidence of association of CTLA4 polymorphisms with Addison's disease. (PubMed id 15621571)1, 4, 9 Perez de Nanclares G....Castano L. (2004)
    238. Cytotoxic T lymphocyte antigen-4 gene in breast cancer. (PubMed id 15218356)1, 4, 9 Ghaderi A....Dehaghani A.S. (2004)
    239. Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients. (PubMed id 14975605)1, 4, 9 Teutsch S.M....Stewart G.J. (2004)
    240. [Study on the relationship of CTLA-4 -318, +49 polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in a Chinese population] (PubMed id 15476165)1, 4, 9 Fan L.Y....Kong X.T. (2004)
    241. [Association between the cytotoxic T lymphocyte antigen-4 gene microsatellite polymorphism and inflammatory bowel diseases in the Chinese] (PubMed id 15059373)1, 4, 9 Jiang Y. and Xia B. (2004)
    242. Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease. (PubMed id 15240634)1, 4, 9 Blomhoff A....Undlien D.E. (2004)
    243. Cytotoxic T-lymphocyte antigen-4-CT60 polymorphism in rheumatoid arthritis. (PubMed id 15546339)1, 4, 9 Orozco G....Martin J. (2004)
    244. Cytotoxic T-lymphocyte antigen-4 A49G polymorphism is associated with susceptibility to and severity of alcoholic liver disease in Italian patients. (PubMed id 15208156)1, 4, 9 Valenti L....Fargion S. (2004)
    245. CTLA-4 (CD152) gene polymorphism at position 49 in exon 1 in Graves' disease in a Polish population of the Lower Silesian region. (PubMed id 15507878)1, 4, 9 Frydecka I....Dobosz T. (2004)
    246. Analysis of 6 genetic loci for disease susceptibility in psoriatic arthritis. (PubMed id 15517637)1, 4, 9 Alenius G.M....Samuelsson L. (2004)
    247. Cytotoxic T lymphocyte antigen-4 gene polymorphisms do not confer susceptibility to autoimmune hepatitis types 1 and 2 in Brazil. (PubMed id 12873588)1, 4, 9 Bittencourt P.L....Goldberg A.C. (2003)
    248. Interactions of HLA-DRB4 and CTLA-4 genes influence thyroid function in Hashimoto's thyroiditis in Japanese population. (PubMed id 15055474)1, 4, 9 Terauchi M....Saruta T. (2003)
    249. Promoter polymorphism of IL-10 and severity of multiple sclerosis. (PubMed id 14616291)1, 4, 9 Luomala M....Elovaara I. (2003)
    250. Genetic background of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: association of HLA-DRB1*0901 with microscopic polyangiitis. (PubMed id 12858454)1, 4, 9 Tsuchiya N....Hashimoto H. (2003)
    251. CTLA-4 exon 1 polymorphism in patients with autoimmune blood disorders. (PubMed id 12555221)1, 4, 9 Pavkovic M....Efremov D.G. (2003)
    252. Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease. (PubMed id 12540792)1, 4, 9 Vidali M....Albano E. (2003)
    253. Lack of association between an exon 1 CTLA-4 gene polymorphism A(49)G and multiple sclerosis in a Polish population of the Lower Silesia region. (PubMed id 12894875)1, 4, 9 Bocko D....Frydecka I. (2003)
    254. Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection. (PubMed id 12696006)1, 4, 9 Yee L.J....Kaslow R.A. (2003)
    255. Analysis of major histocompatibility complex and CTLA-4 alleles in Brazilian patients with primary biliary cirrhosis. (PubMed id 12911663)1, 4, 9 Bittencourt P.L....Goldberg A.C. (2003)
    256. CTLA-4 and CD28 gene polymorphisms in susceptibility, clinical course and progression of multiple sclerosis. (PubMed id 12864988)1, 4, 9 van Veen T....Uitdehaag B.M. (2003)
    257. CDS1 and promoter single nucleotide polymorphisms of the CTLA-4 gene in human myasthenia gravis. (PubMed id 11857062)1, 4, 9 Wang X.B....Lefvert A.K. (2002)
    258. Coding sequence 1 and promoter single nucleotide polymorphisms in the CTLA-4 gene in Wegener's granulomatosis. (PubMed id 12022356)1, 4, 9 Giscombe R....Lefvert A.K. (2002)
    259. CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults. (PubMed id 12021137)1, 4, 9 Cosentino A....Falorni A. (2002)
    260. CTLA-4 gene polymorphisms in systemic lupus erythematosus: a highly significant association with a determinant in the promoter region. (PubMed id 12384790)1, 4, 9 Hudson L.L....Pandey J.P. (2002)
    261. CTLA4 gene polymorphisms in Dutch and Chinese patients with inflammatory bowel disease. (PubMed id 12465728)1, 4, 9 Xia B....Pena A.S. (2002)
    262. Markers for risk of type 1 diabetes in relatives of Alsacian patients with type 1 diabetes. (PubMed id 11900275)1, 4, 9 Ongagna J.C....Belcourt A. (2002)
    263. [Polymorphism A/G in position +49 of CTLA4 exon 1 in multiple sclerosis in Russians] (PubMed id 12173468)1, 4, 9 Andreevskii T.V....Favorova O.O. (2002)
    264. Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population. (PubMed id 11477480)1, 4, 9 McCormack R.M....Savage D.A. (2001)
    265. The promoter region of the CTLA4 gene is associated with type 1 diabetes mellitus. (PubMed id 11327371)1, 4, 9 Lee Y.J....Chang J.G. (2001)
    266. Prevalence of CTLA-4 polymorphism A49G in Ashkenazi Jews. (PubMed id 11788096)1, 4, 9 Mack R....Dermody J. (2001)
    267. CTLA4 gene polymorphism contributes to the mode of onset of diabetes with antiglutamic acid decarboxylase antibody in Japanese patients: genetic analysis of diabetic patients with antiglutamic acid decarboxylase antibody. (PubMed id 11606170)1, 4, 9 Abe T....Eguchi K. (2001)
    268. CTLA-4 gene polymorphisms in Tunisian patients with Graves' disease. (PubMed id 11726229)1, 4, 9 Hadj Kacem H....Ayadi H. (2001)
    269. No association of type 1 diabetes with a microsatellite marker for CTLA-4 in a Japanese population. (PubMed id 11681491)1, 4, 9 Ban Y....Ban Y. (2001)
    270. MHC class II region, CTLA4 gene, and ophthalmopathy in patients with Graves' disease. (PubMed id 11583755)1, 4, 9 Allahabadia A....Gough S.C. (2001)
    271. The length of the CTLA-4 microsatellite (AT)N-repeat affects the risk for type 1 diabetes. Diabetes Incidence in Sweden Study Group. (PubMed id 11092697)1, 4, 9 Lowe R.M....Dahlquist G. (2000)
    272. Association of autoimmune thyroid disease with microsatellite markers for the thyrotropin receptor gene and CTLA-4 in Japanese patients. (PubMed id 11081251)1, 4, 9 Akamizu T....Bowden D.W. (2000)
    273. Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4. (PubMed id 9813138)1, 2, 9 Schneider H....Rudd C.E. (1998)
    274. Novel associations for hypothyroidism include known au toimmune risk loci. (PubMed id 22493691)1, 4 Eriksson N....Do C.B. (2012)
    275. Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients . (PubMed id 20881011)1, 4 Webb R....Sawalha A.H. (2011)
    276. Genome-wide association analysis of autoantibody posit ivity in type 1 diabetes cases. (PubMed id 21829393)1, 4 Plagnol V....Todd J.A. (2011)
    277. Effect of cytotoxic T lymphocyte-associated molecule 4 1661 gene polymorphism on its expression and transcription in ulcerative coli tis. (PubMed id 21091900)1, 4 Jiang T....Xia B. (2010)
    278. HLA-DRB1*11: a strong risk factor for acquired severe ADAMTS13 deficiency-related idiopathic thrombotic thrombocytopenic purpura in Caucasians. (PubMed id 20141578)1, 4 Coppo P....Loiseau P. (2010)
    279. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    280. Changes in frequency of IDDM-associated HLA DQB, CTLA 4 and INS alleles. (PubMed id 20345871)1, 4 Witas H.W....Zawicki P. (2010)
    281. A targeted association study in systemic lupus erythe matosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (2010)
    282. Investigation of potential non-HLA rheumatoid arthrit is susceptibility loci in a European cohort increases the evidence for nine mar kers. (PubMed id 20498205)1, 4 Plant D....Worthington J. (2010)
    283. Cumulative association of 22 genetic variants with se ropositive rheumatoid arthritis risk. (PubMed id 20233754)1, 4 Karlson E.W....Plenge R.M. (2010)
    284. Genetic variants in the prediction of rheumatoid arth ritis. (PubMed id 20439292)1, 4 van der Helm-van Mil A.H....Huizinga T.W. (2010)
    285. Association of a functional polymorphism of PTPN22 en coding a lymphoid protein phosphatase in bilateral Meniere's disease. (PubMed id 19780033)1, 4 Lopez-Escamez J.A....Lopez-Nevot M.A. (2010)
    286. Genome-wide association study meta-analysis identifie s seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (2010)
    287. Association between the Cytotoxic T-lymphocyte antige n 4 +49G > A polymorphism and cancer risk: a meta-analysis. (PubMed id 20920330)1, 4 Zheng J....Zhou Y. (2010)
    288. CTLA-4 gene polymorphism +49 A/G contributes to genet ic susceptibility to two infection-related cancers-hepatocellular carcinoma and cervical cancer. (PubMed id 20538028)1, 4 Hu L....Hu Z. (2010)
    289. CTLA4 CT60 A/G gene polymorphism in liver transplant recipients. (PubMed id 20716038)1, 4 Azarpira N....Daraie M. (2010)
    290. Association analysis of cytotoxic T-lymphocyte antige n 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients. (PubMed id 20557968)1, 4 Joshita S....Ota M. (2010)
    291. [The analysis of 49A/G CTLA4 gene polymorphism associ ation with development of allergic rhinitis]. (PubMed id 20608155)1, 4 Alieva V.S.h....Boboev K.T. (2010)
    292. Carriage of a tumor necrosis factor polymorphism ampl ifies the cytotoxic T-lymphocyte antigen 4 attributed risk of primary biliary c irrhosis: evidence for a gene-gene interaction. (PubMed id 20578265)1, 4 Juran B.D....Lazaridis K.N. (2010)
    293. Analysis of multiple candidate genes in association w ith phenotypes of multiple sclerosis. (PubMed id 20378664)1, 4 Sombekke M.H....Uitdehaag B.M. (2010)
    294. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    295. Independent predictive roles of eotaxin Ala23Thr, par aoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on car diac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients. (PubMed id 20536507)1, 4 Wang Y....Chan J.C. (2010)
    296. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    297. Population based allele frequencies of disease associ ated polymorphisms in the Personalized Medicine Research Project. (PubMed id 20565774)1, 4 Cross D.S....McCarty C.A. (2010)
    298. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
    299. Genetically determined amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus. (PubMed id 20848568)1, 4 Sanchez E....AlarcA^n-Riquelme M.E. (2010)
    300. Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-t umour necrosis factor treatment. (PubMed id 20444755)1, 4 Tan R.J....Barton A. (2010)
    301. Replication of genetic association studies in asthma and related phenotypes. (PubMed id 20395963)1, 4 Undarmaa S....Suzuki Y. (2010)
    302. [CTLA-4 gene polymorphism regulates CTLA-4 mRNA stabi lity and protein level in patients with ulcerative colitis]. (PubMed id 21154316)1, 4 Chen Z.T....Ge L.Q. (2010)
    303. Evaluation of six CTLA-4 polymorphisms in high-risk m elanoma patients receiving adjuvant interferon therapy in the He13A/98 multicen ter trial. (PubMed id 21044351)1, 4 Gogas H....Kirkwood J.M. (2010)
    304. Genetic markers in acquired haemophilia. (PubMed id 20586801)1, 4 Oldenburg J....Pavlova A. (2010)
    305. CTLA-4 +49A>G polymorphism of recipients of HLA-ma tched sibling allogeneic stem cell transplantation is associated with survival and relapse incidence. (PubMed id 20020126)1, 4 Piccioli P....Pistillo M.P. (2010)
    306. CTLA4 -1661A/G and 3'UTR long repeat polymorphisms ar e associated with ulcerative colitis and influence CTLA4 mRNA and protein expre ssion. (PubMed id 20445568)1, 4 Chen Z....Xia B. (2010)
    307. Association of CTLA4 gene polymorphism in Iranian pat ients with ankylosing spondylitis. (PubMed id 20012554)1, 4 Azizi E....Nicknam M.H. (2010)
    308. The influence of CTLA-4 gene polymorphism on long-ter m kidney allograft function in Caucasian recipients. (PubMed id 20470888)1, 4 Kusztal M....Klinger M. (2010)
    309. ctla-4 gene variations may influence cervical cancer susceptibility. (PubMed id 20615526)1, 4 Rahimifar S....Ghaderi A. (2010)
    310. Evidence for CTLA4 as a susceptibility gene for dilat ed cardiomyopathy. (PubMed id 20145677)1, 4 Ruppert V....Pankuweit S. (2010)
    311. Investigation of CTLA-4 and CD28 gene polymorphisms i n patients with diabetes mellitus type 2 using PCR-RFLP in a Turkish population . (PubMed id 21291098)1, 4 Uzer E....van Kuilenburg A.B. (2010)
    312. Comprehensive Association Analysis of Candidate Genes for Generalized Vitiligo Supports XBP1, FOXP3, and TSLP. (PubMed id 21085187)1, 4 Birlea S.A....Spritz R.A. (2010)
    313. The CTLA4 variants may interact with the IL23R- and N OD2-conferred risk in development of Crohn's disease. (PubMed id 20537165)1, 4 Hradsky O....Cinek O. (2010)
    314. Association of single nucleotide polymorphisms in cyt otoxic T-lymphocyte antigen 4 and susceptibility to autoimmune type 1 diabetes in Tunisians. (PubMed id 20610662)1, 4 Benmansour J....Almawi W.Y. (2010)
    315. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    316. Cytotoxic T lymphocyte antigen-4 (CTLA-4) polymorphis m in patients with BehAset's disease. (PubMed id 20868585)1, 4 DA1zgA1n N....Tutkak H. (2010)
    317. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    318. Association of cytotoxic T lymphocyte-associated anti gen-4 gene haplotype with the susceptibility to gastric cancer. (PubMed id 19688278)1, 4 Hou R....Chen Z. (2010)
    319. Polymorphisms in the 2q33 and 3q21 chromosome regions including T-cell coreceptor and ligand genes may influence susceptibility to p emphigus foliaceus. (PubMed id 20433886)1, 4 Dalla-Costa R....Petzl-Erler M.L. (2010)
    320. Association of CT60 cytotoxic T lymphocyte antigen-4 gene polymorphism with thyroid autoantibody production in patients with Hashimo to's and postpartum thyroiditis. (PubMed id 20408864)1, 4 Zaletel K....Hojker S. (2010)
    321. Association of candidate susceptible loci with chroni c infection with hepatitis B virus in a Chinese population. (PubMed id 20087947)1, 4 Chen D.Q....Zheng B.J. (2010)
    322. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (2010)
    323. CTLA4 CT60 Single-Nucleotide Polymorphism Is Associat ed with Slovenian Inflammatory Bowel Disease Patients and Regulates Expression of CTLA4 Isoforms. (PubMed id 20491567)1, 4 Repnik K. and PotoA8nik U. (2010)
    324. The cytotoxic lymphocyte antigen 4 polymorphisms affe ct response to hepatitis C virus-specific therapy in HIV(+) patients with acute and chronic hepatitis C virus co-infection. (PubMed id 20588168)1, 4 Nischalke H.D....Nattermann J. (2010)
    325. Single nucleotide polymorphisms in inflammation-relat ed genes are associated with venous thromboembolism. (PubMed id 20603037)1, 4 Beckers M.M....Biesma D.H. (2010)
    326. PD1 as a common candidate susceptibility gene of suba cute sclerosing panencephalitis. (PubMed id 20066438)1, 4 Ishizaki Y....Hara T. (2010)
    327. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    328. In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium. (PubMed id 20378605)1, 4 Qu H.Q....Polychronakos C. (2010)
    329. Latent autoimmune diabetes in adults differs genetica lly from classical type 1 diabetes diagnosed after the age of 35 years. (PubMed id 20805278)1, 4 Andersen M.K....Tuomi T. (2010)
    330. Cytotoxic T-lymphocyte-associated antigen 4 gene poly morphisms in Japanese children with infection-associated hemophagocytic lymphoh istiocytosis. (PubMed id 20224272)1, 4 Yoshiyama M....Yoshikawa N. (2010)
    331. Genome-wide association study in alopecia areata impl icates both innate and adaptive immunity. (PubMed id 20596022)1, 4 Petukhova L....Christiano A.M. (2010)
    332. Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia. (PubMed id 20716621)1, 4 Chang J.S....Buffler P.A. (2010)
    333. Polymorphisms in the CD28/CTLA4/ICOS genes: role in m alignant melanoma susceptibility and prognosis? (PubMed id 19672595)1, 4 Bouwhuis M.G....Kumar R. (2009)
    334. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    335. CTLA4 variants, UV-induced tolerance, and risk of non -melanoma skin cancer. (PubMed id 19622768)1, 4 Welsh M.M....Nelson H.H. (2009)
    336. Association of PTPN22 C1858T and CTLA-4 A49G polymorp hisms with Type 1 Diabetes in Croatians. (PubMed id 19815302)1, 4 Korolija M....Hadzija M.P. (2009)
    337. Associations of the CTLA-4 polymorphisms with type 1 diabetes in a Chilean population: case-parent design. (PubMed id 19592124)1, 4 Angel B....PAcrez-Bravo F. (2009)
    338. Interplay between PTPN22 C1858T polymorphism and cow' s milk formula exposure in type 1 diabetes. (PubMed id 19473815)1, 4 Lempainen J....Ilonen J. (2009)
    339. Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling. (PubMed id 19479237)1, 4 Song X.Y....Chan J.C. (2009)
    340. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    341. A candidate gene association study of 77 polymorphism s in migraine. (PubMed id 19559392)1, 4 SchA1rks M....Zee R.Y. (2009)
    342. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1, 4 Barrett J.C....Rich S.S. (2009)
    343. CTLA-4 +49A/G polymorphism is associated with BehAset's disease in a Tunisian population. (PubMed id 19254250)1, 4 Ben Dhifallah I....Houman M.H. (2009)
    344. Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach. (PubMed id 19263529)1, 4 Zee R.Y....Glynn R.J. (2009)
    345. REL, encoding a member of the NF-kappaB family of tra nscription factors, is a newly defined risk locus for rheumatoid arthritis. (PubMed id 19503088)1, 4 Gregersen P.K....Siminovitch K.A. (2009)
    346. Variation in the Lymphotoxin-alpha/Tumor Necrosis Factor Locus Modifies Risk of Erythema Nodosum in Sarcoidosis. (PubMed id 19225544)1, 4 McDougal K.E....Cutting G.R. (2009)
    347. Type 1 diabetes susceptibility determined by HLA alle les and CTLA-4 and insulin genes polymorphisms in Brazilians. (PubMed id 19578600)1, 4 Ferreira A.C....Godard A.L. (2009)
    348. Analyses of associations with asthma in four asthma population samples from Canada and Australia. (PubMed id 19247692)1, 4 Daley D....Hudson T.J. (2009)
    349. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    350. Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGFbeta gene variants. (PubMed id 19173720)1, 4 Barreto M....Vicente A.M. (2009)
    351. Racial disparity in pathophysiologic pathways of pret erm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (2009)
    352. Common Variants in Immune and DNA Repair Genes and Risk for Human Papillomavirus Persistence and Progression to Cervical Cancer. (PubMed id 19012493)1, 4 Wang S.S....Hildesheim A. (2009)
    353. Association and interaction analyses of eight genes u nder asthma linkage peaks. (PubMed id 19824886)1, 4 Ferreira M.A....Duffy D.L. (2009)
    354. MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth. (PubMed id 19143820)1, 4 Badenhoop K....BAPhm B.O. (2009)
    355. Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay. (PubMed id 19028820)1, 4 Greisenegger S....Mannhalter C. (2009)
    356. Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes? (PubMed id 19188433)1, 4 Steck A.K....Rewers M.J. (2009)
    357. Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions. (PubMed id 19735272)1, 4 Kim S.H....Park H.W. (2009)
    358. Association of Type 1 Diabetes with Two Loci on 12q13 and 16p13 and the Influence Coexisting Thyroid Autoimmunity in Japanese. (PubMed id 18940880)1, 4 Awata T....Katayama S. (2009)
    359. Long-term follow-up of autoimmune pancreatitis: chara cteristics of chronic disease and recurrence. (PubMed id 19896092)1, 4 Kawa S....Arakura N. (2009)
    360. Autoimmune thyroiditis and diabetes: dissecting the joint genetic susceptibility in a large cohort of multiplex families. (PubMed id 19141582)1, 4 Villano M.J....Tomer Y. (2009)
    361. Association between genotypes and phenotypes in coeli ac disease. (PubMed id 19543113)1, 4 GudjA^nsdA^ttir A.H....Ascher H. (2009)
    362. Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms and HLA class II alleles with the development of type 1 diabetes in Korean children and adolescents. (PubMed id 19949652)1, 4 Jung M.H....Lee B.C. (2009)
    363. Polymorphisms in genes involved in autoimmune disease and the risk of FVIII inhibitor development in Italian patients with haemophil ia A. (PubMed id 20015215)1, 4 Bafunno V....Margaglione M. (2009)
    364. CT60 and +49 polymorphisms of CTLA 4 are associated w ith ANCA-positive small vessel vasculitis. (PubMed id 19815671)1, 4 Kamesh L....Harper L. (2009)
    365. Single nucleotide polymorphism of TAG-1 influences IV Ig responsiveness of Japanese patients with CIDP. (PubMed id 19776380)1, 4 Iijima M....Sobue G. (2009)
    366. Pretibial myxedema is associated with polymorphism in exon 1 of CTLA-4 gene in patients with Graves' ophthalmopathy. (PubMed id 19037649)1, 4 Khalilzadeh O....Amirzargar A. (2009)
    367. A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. (PubMed id 19131662)1, 4 Wang X....Cook N.R. (2009)
    368. An inverse association between history of childhood e czema and subsequent risk of type 1 diabetes that is not likely to be explained by HLA-DQ, PTPN22, or CTLA4 polymorphisms. (PubMed id 19895409)1, 4 Stene L.C....Joner G. (2009)
    369. Cytotoxic T lymphocyte-associated antigen-4 polymorph ism in patients with rheumatic heart disease. (PubMed id 19737369)1, 4 DA1zgA1n N....Tutkak H. (2009)
    370. Assessing the Reproducibility of Asthma Candidate Gene Associations Using Genome-wide Data. (PubMed id 19264973)1, 4 Rogers A.J....Weiss S.T. (2009)
    371. The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency. (PubMed id 19020530)1, 4 Haimila K....Saavalainen P. (2008)
    372. Differences in the contribution of the CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patients. (PubMed id 18443194)1, 4 Kawasaki E....Eguchi K. (2008)
    373. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (2008)
    374. CTLA-4 +49 A/G genotype and HLA-DRB1 polymorphisms in Turkish patients with Henoch-Schonlein purpura. (PubMed id 18449568)1, 4 Soylemezoglu O....Hasanoglu E. (2008)
    375. Polymorphism of the oestrogen receptor beta gene (ESR2) is associated with susceptibility to Graves' disease. (PubMed id 17941906)1, 4 Kisiel B....Pl/oski R. (2008)
    376. Analysis of single nucleotide polymorphisms in the FA S and CTLA-4 genes of peripheral T-cell lymphomas. (PubMed id 19669200)1, 4 Bonzheim I....RA1diger T. (2008)
    377. Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the DPT1 trial. (PubMed id 18556337)1, 4 Butty V....Benoist C. (2008)
    378. Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis. (PubMed id 18974840)1, 4 Atik B....Dean D. (2008)
    379. Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study. (PubMed id 17666451)1, 4 Karlson E.W....Shadick N.A. (2008)
    380. Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era. (PubMed id 18633131)1, 4 Habermann T.M....Cerhan J.R. (2008)
    381. Investigation of CTLA-4 and CD28 gene polymorphisms in a group of Turkish patients with colorectal cancer. (PubMed id 18680513)1, 4 Dilmec F....Akkafa F. (2008)
    382. Shared and distinct genetic variants in type 1 diabetes and celiac disease. (PubMed id 19073967)1, 4 Smyth D.J....Todd J.A. (2008)
    383. CTLA-4 gene variants are not associated with BehAset's disease or its clinical manifestations. (PubMed id 19026137)1, 4 Touma Z....Arayssi T. (2008)
    384. CTLA-4 single-nucleotide polymorphisms in a Caucasian population with schizophrenia. (PubMed id 18848621)1, 4 Jones A.L....Greer J.M. (2008)
    385. Association of autoimmune pancreatitis with cytotoxic T-lymphocyte antigen 4 gene polymorphisms in Japanese patients. (PubMed id 18341485)1, 4 Umemura T....Kiyosawa K. (2008)
    386. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    387. Genetic factors of susceptibility and of severity in primary biliary cirrhosis. (PubMed id 18930330)1, 4 Poupon R....Barbu V. (2008)
    388. Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes. (PubMed id 18292987)1, 4 Bjornvold M....Stene L.C. (2008)
    389. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (2008)
    390. Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children. (PubMed id 18691306)1, 4 Chan I.H....Lam C.W. (2008)
    391. Association of the CTLA-4 gene with Vogt-Koyanagi-Harada syndrome. (PubMed id 18282809)1, 4 Du L....Kijlstra A. (2008)
    392. CTLA-4 CT60 polymorphism is not an independent genetic risk marker of rheumatoid arthritis in a Japanese population. (PubMed id 18292106)1, 4 Tsukahara S....Momohara S. (2008)
    393. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. (PubMed id 18636124)1, 4 Skibola C.F....Smith M.T. (2008)
    394. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. (PubMed id 18978792)1, 4 Cooper J.D....Todd J.A. (2008)
    395. Cytotoxic T lymphocyte antigen 4 gene polymorphism associated with ST-segment elevation acute myocardial infarction. (PubMed id 17652883)1, 4 Yip H.K....Wu C.J. (2007)
    396. Polymorphisms in the CTLA-4 gene and inhibitor development in patients with severe hemophilia A. (PubMed id 17269936)1, 4 Astermark J....Lefvert A.K. (2007)
    397. No evidence of association of CTLA-4 -318 C/T, 159 C/T, 3' STR and SUMO4 163 AG polymorphism with autoimmune diabetes. (PubMed id 17558709)1, 4 Caputo M....Gustavo D.F. (2007)
    398. CTLA-4 gene promoter and exon 1 polymorphisms in Iranian patients with gastric and colorectal cancers. (PubMed id 18031393)1, 4 Hadinia A....Ghaderi A. (2007)
    399. CT60 genotype does not affect CTLA-4 isoform expression despite association to T1D and AITD in northern Sweden. (PubMed id 17280620)1, 4 Mayans S....Holmberg D. (2007)
    400. Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15. (PubMed id 18466513)1, 4 Mei L....Rotter J.I. (2007)
    401. CTLA-4 gene and susceptibility to human papillomavirus-16-associated cervical squamous cell carcinoma in Taiwanese women. (PubMed id 17341658)1, 4 Su T.H....Yang Y.C. (2007)
    402. Cytotoxic T lymphocyte-associated molecule-4 gene polymorphism and hyperthyroid Graves' disease relapse after antithyroid drug withdrawal: a follow-up study. (PubMed id 17426089)1, 4 Wang P.W....Juo S.H. (2007)
    403. Genetic analyses of celiac disease in a Spanish population confirm association with CELIAC3 but not with CELIAC4. (PubMed id 17767555)1, 4 Capilla A....Palau F. (2007)
    404. Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes. (PubMed id 17209142)1, 4 Payne F....Todd J.A. (2007)
    405. Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study. (PubMed id 17937736)1, 4 Eising S....Nerup J. (2007)
    406. Helicobacter pylori-induced indoleamine 2,3-dioxygenase activity in vivo is regulated by TGFB1 and CTLA4 polymorphisms. (PubMed id 16620985)1, 4 Raitala A....Hurme M. (2007)
    407. Genetic analysis of the exon 1 position 49 CD152 dimorphism in multiple sclerosis. (PubMed id 17920697)1, 4 Stuart R....Racke M.K. (2007)
    408. CTLA-4 polymorphisms and clinical outcome after allogeneic stem cell transplantation from HLA-identical sibling donors. (PubMed id 17384200)1, 4 Perez-Garcia A....Gallardo D. (2007)
    409. Insulin gene VNTR, CTLA-4 +49A/G and HLA-DQB1 alleles distinguish latent autoimmune diabetes in adults from type 1 diabetes and from type 2 diabetes group. (PubMed id 17257313)1, 4 Haller K....Uibo R. (2007)
    410. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    411. Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes. (PubMed id 18056379)1, 4 Hunter K....Wicker L.S. (2007)
    412. Case-control association analysis of rheumatoid arthritis with candidate genes using related cases. (PubMed id 18466531)1, 4 Yoo Y.J....Zhang K. (2007)
    413. Influence of CTLA4 haplotypes on susceptibility and some extraglandular manifestations in primary Sjogren's syndrome. (PubMed id 16869018)1, 4 Downie-Doyle S....Lester S. (2006)
    414. Promoter region -318 C/ T and -1661 A/G CTLA-4 single nucleotide polymorphisms and type 1 diabetes in North Indians. (PubMed id 16671945)1, 4 Baniasadi V....Das S.N. (2006)
    415. The influence of CTLA-4 gene polymorphisms on liver transplant outcomes. (PubMed id 17004266)1, 4 Perkins J.D. (2006)
    416. Polymorphism of the promoter region and exon 1 of the CTLA4 gene in endemic pemphigus foliaceus (fogo selvagem). (PubMed id 16972006)1, 4 Pavoni D.P....Petzl-Erler M.L. (2006)
    417. Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves' disease: the impact of DRB1*07. (PubMed id 16756466)1, 4 Kula D....Jarzab B. (2006)
    418. Polymorphisms in the T cell regulatory gene cytotoxic T lymphocyte antigen 4 influence the rate of acute rejection after liver transplantation. (PubMed id 16299026)1, 4 Tapirdamaz O....Kwekkeboom J. (2006)
    419. No association between selected candidate gene polymorphisms and severe chronic periodontitis. (PubMed id 16512757)1, 4 Wohlfahrt J.C....Michalowicz B.S. (2006)
    420. Cohort- and time-specific associations of CTLA4 genotypes with HIV-1 disease progression. (PubMed id 16868438)1, 4 Shao W....Kaslow R.A. (2006)
    421. [Susceptibility genes for the development of autoimmune thyroid disease] (PubMed id 17154080)1, 4 Shirasawa S. (2006)
    422. [Study on association of CTLA4 gene polymorphism with Grave's disease in Guangxi Zhuang nationality population] (PubMed id 16767670)1, 4 Liang X.H....Luo Z.J. (2006)
    423. Genetic association of type 1 diabetes in an Azerbaijanian population: the HLA-DQ, -DRB1*04, the insulin gene, and CTLA4. (PubMed id 16629714)1, 4 Ahmedov G....Cinek O. (2006)
    424. Association of T-cell regulatory gene polymorphisms with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma. (PubMed id 16849765)1, 4 Cheng T.Y....Wu M.S. (2006)
    425. No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis. (PubMed id 16638702)1, 4 Wiencke K....Spurkland A. (2006)
    426. Possible association of cytotoxic T-lymphocyte antigen 4 gene promoter single nucleotide polymorphism with acute rejection of allogeneic kidney transplant. (PubMed id 16504663)1, 4 Wisniewski A....Kusnierczyk P. (2006)
    427. A CTLA4high genotype is associated with myasthenia gravis in thymoma patients. (PubMed id 16178018)1, 4 Chuang W.Y....Marx A. (2005)
    428. Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease. (PubMed id 16279844)1, 4 Kurylowicz A....Bednarczuk T. (2005)
    429. Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients. (PubMed id 16005527)1, 4 Lorentzen A.R....Harbo H.F. (2005)
    430. Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes. (PubMed id 16259622)1, 4 Purohit S....She J.X. (2005)
    431. Hierarchical regulation of CTLA-4 dimer-based lattice formation and its biological relevance for T cell inactivation. (PubMed id 16002699)1, 2 Darlington P.J....Madrenas J. (2005)
    432. Estimation of diabetes risk in Brazilian population by typing for polymorphisms in HLA-DR-DQ, INS and CTLA-4 genes. (PubMed id 16276008)1, 4 Hauache O.M....Ilonen J. (2005)
    433. Meta-analysis of the association of CTLA-4 exon-1 +49A/G polymorphism with rheumatoid arthritis. (PubMed id 16133179)1, 4 Han S....Xie Y. (2005)
    434. Lymphoid tyrosine phosphatase (PTPN22/LYP) variant and Graves' disease in a Polish population: association and gene dose-dependent correlation with age of onset. (PubMed id 15943829)1, 4 Skorka A....Ploski R. (2005)
    435. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    436. Detection and frequency estimation of rare variants in pools of genomic DNA from large populations using mutational spectrometry. (PubMed id 15708585)1, 4 Li-Sucholeiki X.C....Thilly W.G. (2005)
    437. Genetic analysis of the 2q33 region containing CD28-CTLA4-ICOS genes: association with non-Hodgkin's lymphoma. (PubMed id 15953005)1, 4 Piras G....Gabbas A. (2005)
    438. Association between IL-18 gene promoter polymorphisms and CTLA-4 gene 49A/G polymorphism in Japanese patients with type 1 diabetes. (PubMed id 14709415)1, 4 Ide A....Eguchi K. (2004)
    439. Complex genetic predisposition in adult and juvenile rheumatoid arthritis. (PubMed id 15018649)1, 4 Miterski B....Epplen J.T. (2004)
    440. Progression of multiple sclerosis is associated with exon 1 CTLA-4 gene polymorphism. (PubMed id 15180809)1, 4 Bilinska M....Pokryszko-Dragan A. (2004)
    441. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    442. Cytotoxic T lymphocyte-associated molecule-4 polymorphism and relapse of Graves' hyperthyroidism after antithyroid withdrawal. (PubMed id 14715845)1, 4 Wang P.W....Wu C.L. (2004)
    443. No evidence for an association of the CTLA4 gene with bipolar I disorder. (PubMed id 14678452)1, 4 Jun T.Y....Han H. (2004)
    444. Analysis of immune regulatory genes in familial and sporadic Graves' disease. (PubMed id 15356063)1, 4 Ban Y....Tomer Y. (2004)
    445. Association of CTLA-4 gene polymorphism with oral submucous fibrosis in Taiwan. (PubMed id 15061706)1, 4 Shin Y.N....Liu H.F. (2004)
    446. Association of the T-cell regulatory gene CTLA4 with Graves' disease and autoimmune thyroid disease in the Japanese. (PubMed id 14986169)1, 4 Furugaki K....Sasazuki T. (2004)
    447. Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA4 gene. (PubMed id 15301861)1, 4 Zalloua P.A....Azar S.T. (2004)
    448. Type 1 diabetes is insulin -2221 MspI and CTLA-4 +49 A/G polymorphism dependent. (PubMed id 15305888)1, 4 Haller K....Uibo R. (2004)
    449. Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection. (PubMed id 15452244)1, 2 Thio C.L.... Thomas D.L. (2004)
    450. Association between CTLA-4 +49 A/G polymorphism and type 1B diabetes in Japanese population. (PubMed id 15711022)1, 4 Liang H....Mabuchi H. (2004)
    451. CTLA4 +49 A/G and CT60 polymorphisms in Dutch coeliac disease patients. (PubMed id 15199380)1, 4 van Belzen M.J....Wijmenga C. (2004)
    452. CTLA-4 dimorphisms in Japanese patients with systemic lupus erythematosus. (PubMed id 12942714)1, 4 Takeuchi F....Tanimoto K. (2003)
    453. CTLA4 is associated with susceptibility to multiple sclerosis. (PubMed id 12507781)1, 4 Kantarci O.H....Weinshenker B.G. (2003)
    454. A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. (PubMed id 12732844)1, 4 Watanabe I....Koga T. (2003)
    455. Population frequencies of single nucleotide polymorphisms (SNPs) in immuno-modulatory genes. (PubMed id 14566095)1, 4 Martin A.M....Weber B.L. (2003)
    456. Coeliac disease: investigation of proposed causal variants in the CTLA4 gene region. (PubMed id 14675397)1, 4 King A.L....Ciclitira P.J. (2003)
    457. Association of the CTLA-4 gene 49 A/G polymorphism with type 1 diabetes and autoimmune thyroid disease in Japanese children. (PubMed id 12610047)1, 4 Mochizuki M....Nanazawa S. (2003)
    458. Recipient ctla-4 +49 G/G genotype is associated with reduced incidence of acute rejection after liver transplantation. (PubMed id 14629291)1, 4 de Reuver P....Kwekkeboom J. (2003)
    459. Association of the CTLA4 promoter region (-1661G allele) with type 1 diabetes in the South Moroccan population. (PubMed id 12618861)1, 4 Bouqbis L....Comas D. (2003)
    460. Association of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene polymorphism and non-genetic factors with Graves' ophthalmopathy in European and Japanese populations. (PubMed id 12534352)1, 4 Bednarczuk T....Nauman J. (2003)
    461. Association of CTLA-4 variation with type I diabetes in Filipinos. (PubMed id 12185534)1, 4 Klitz W....Erlich H.A. (2002)
    462. CTLA4 dimorphisms and the multiple sclerosis phenotype. (PubMed id 12458054)1, 4 Masterman T....Hillert J. (2002)
    463. Remission of Graves' hyperthyroidism and A/G polymorphism at position 49 in exon 1 of cytotoxic T lymphocyte-associated molecule-4 gene. (PubMed id 12050220)1, 4 Kinjo Y....Yoshimura H. (2002)
    464. CTLA-4/CD28 gene region is associated with genetic susceptibility to coeliac disease in UK families. (PubMed id 11826026)1, 4 King A.L....Ciclitira P.J. (2002)
    465. CTLA4 exon 1 dimorphism is associated with primary progressive multiple sclerosis. (PubMed id 12458055)1, 4 Maurer M....Rieckmann P. (2002)
    466. Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom. (PubMed id 11842815)1, 4 Nithiyananthan R....Gough S.C. (2002)
    467. Polymorphism of CTLA-4 gene at position 49 of exon 1 may be associated with schizophrenia in the Korean population. (PubMed id 12007590)1, 4 Jun T.Y....Han H. (2002)
    468. CTLA-4 gene A-G polymorphism and childhood Graves' disease. (PubMed id 12030917)1, 4 Yung E....Wong G.W. (2002)
    469. Association of asthma severity and bronchial hyperresponsiveness with a polymorphism in the cytotoxic T-lymphocyte antigen-4 gene. (PubMed id 12114354)1, 4 Lee S.Y....In K.H. (2002)
    470. A recently described polymorphism in the CD28 gene on chromosome 2q33 is not associated with susceptibility to type 1 diabetes. (PubMed id 12121283)1, 4 Wood J.P....Badenhoop K. (2002)
    471. The CTLA4 +49 A/G dimorphism is not associated with type 1 diabetes in Czech children. (PubMed id 12047357)1, 4 Cinek O....Vavrinec J. (2002)
    472. CTLA-4 49 A/G dimorphism and type 1 diabetes susceptibility: a French case-control study and segregation analysis. Evidence of a maternal effect. (PubMed id 12047362)1, 4 Fajardy I....Fontaine P. (2002)
    473. The influence of the exon 1 polymorphism of the cytotoxic T lymphocyte antigen 4 gene on thyroid antibody production in patients with newly diagnosed Graves' disease. (PubMed id 12097196)1, 4 Zaletel K....Hojker S. (2002)
    474. Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes. (PubMed id 11978629)1, 4 Graham J.... . (2002)
    475. Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches. (PubMed id 11735222)1, 2 Ling V.... Collins M. (2001)
    476. Polymorphism in codon 17 of the CTLA-4 gene (+49 A/G) is not associated with susceptibility to rheumatoid arthritis in British Caucasians. (PubMed id 11580858)1, 4 Milicic A....Wordsworth B.P. (2001)
    477. Cytotoxic T-lymphocyte antigen-4 microsatellite polymorphism is associated with multiple myeloma. (PubMed id 11167807)1, 4 Zheng C....Sundblad A. (2001)
    478. Polymorphism of CTLA-4 gene for major depression in the Korean population. (PubMed id 11555351)1, 4 Jun T.Y....Kim K.S. (2001)
    479. Association of a novel point mutation (C159G) of the CTLA4 gene with type 1 diabetes in West Africans but not in Chinese. (PubMed id 11522687)1, 4 Osei-Hyiaman D....Harada S. (2001)
    480. [Association between type 1 diabetes and polymorphism of the CTLA-4 gene in a Tunisian population] (PubMed id 11776689)1, 4 Kamoun Abid H....Nagati K. (2001)
    481. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. (PubMed id 10903931)1, 2 Deng Z....Knowles J.A. (2000)
    482. CD28/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family-based association study. (PubMed id 10372542)1, 4 Holopainen P....Partanen J. (1999)
    483. Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders. (PubMed id 10493833)1, 2 Ling V.... Collins M. (1999)
    484. Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28. (PubMed id 9228944)1, 2 Metzler W.J....Linsley P.S. (1997)
    485. CTLA-4 is a second receptor for the B cell activation antigen B7. (PubMed id 1714933)1, 2 Linsley P.S....Ledbetter J.A. (1991)
    486. CTLA-4 is not restricted to the lymphoid cell lineage and can function as a target molecule for apoptosis induction of leukemic cells. (PubMed id 12393538)1, 9 Pistillo M.P....Ferrara G.B. (2003)
    487. Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter. (PubMed id 17785820)1, 9 Gibson H.M....Wong H.K. (2007)
    488. Cyclic adenosine 5'-monophosphate and calcium induce CD152 (CTLA-4) up-regulation in resting CD4+ T lymphocytes. (PubMed id 12444128)1, 9 Vendetti S....De Magistris M.T. (2002)
    489. Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3. (PubMed id 18641304)1, 9 Zheng Y....Sansom D.M. (2008)
    490. Increased production of soluble CTLA-4 in patients wi th spondylarthropathies correlates with disease activity. (PubMed id 19570209)1, 9 Toussirot E....Wendling D. (2009)
    491. Surface CD152 (CTLA-4) expression and signaling dictates longevity of CD28(null) T cells. (PubMed id 19380781)1, 9 Hoff H....Brunner-Weinzierl M.C. (2009)
    492. CTLA-4 AT-repeat polymorphism reduces the inhibitory function of CTLA-4 in Graves' disease. (PubMed id 14751028)1, 9 Takara M....DeGroot L.J. (2003)
    493. Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells. (PubMed id 12355442)1, 9 Manzotti C.N....Sansom D.M. (2002)
    494. Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases. (PubMed id 9973379)1, 9 Chuang E....Thompson C.B. (1999)
    495. Regulation of CD28 expression on CD8+ T cells by CTLA-4. (PubMed id 18162511)1, 9 Berg M. and Zavazava N. (2008)
    496. Increased expression of CTLA-4 in malignant T-cells from patients with mycosis fungoides -- cutaneous T cell lymphoma. (PubMed id 16417239)1, 9 Wong H.K....Lim H.W. (2006)
    497. Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation. (PubMed id 12021313)1, 9 Darlington P.J....Madrenas J. (2002)
    498. Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A. (PubMed id 11994459)1, 9 Baroja M.L....Kuchroo V.K. (2002)
    499. Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein. (PubMed id 9256472)1, 9 Zhang Y. and Allison J.P. (1997)
    500. TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells. (PubMed id 20016783)1, 9 Elrefaei M....Cao H. (2009)
    501. Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. (PubMed id 19036923)1, 9 Flores-Borja F....Ehrenstein M.R. (2008)
    502. Adult T-cell leukemia/lymphoma cells from blood and skin tumors express cytotoxic T lymphocyte-associated antigen-4 and Foxp3 but lack suppressor activity toward autologous CD8+ T cells. (PubMed id 17970785)1, 9 Shimauchi T....Tokura Y. (2008)
    503. CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors. (PubMed id 18563180)1, 9 Shah K.V....Moon R.T. (2008)
    504. TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression. (PubMed id 17082597)1, 9 Bulwin G.C....Utku N. (2006)
    505. CTLA-4 expression in T cells of patients with atopic dermatitis. (PubMed id 16101935)1, 9 Choi S.Y....Kim K.E. (2005)
    506. Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells. (PubMed id 15814706)1, 9 Mead K.I....Sansom D.M. (2005)
    507. Two different forms of human CTLA-4 proteins following peripheral T cell activation. (PubMed id 15019292)1, 9 Chun T....Chung Y.H. (2004)
    508. A linkage analysis of the CTLA4 gene region in Finnish patients with type 1 diabetes. (PubMed id 12919291)4, 9 Turpeinen H....Ilonen J. (2003)
    509. CTLA-4 and autoimmune thyroid disease: lack of influence of the A49G signal peptide polymorphism on functional recombinant human CTLA-4. (PubMed id 12202150)1, 9 Xu Y....Davies T.F. (2002)
    510. Increased total serum IgE levels in patients with asthma and promoter polymorphisms at CTLA4 and FCER1B. (PubMed id 11447385)4, 9 Hizawa N....Nishimura M. (2001)
    511. Lack of association between CTLA-4 gene polymorphism and IDDM in Japanese subjects. (PubMed id 10052685)4, 9 Yanagawa T....Saruta T. (1999)
    512. Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152). (PubMed id 9712716)1, 9 Miyatake S....Saito T. (1998)
    513. Common polymorphisms in the CTLA-4 and CD28 genes at 2q33 are not associated with asthma or atopy. (PubMed id 10792419)4, 9 Heinzmann A....Deichmann K.A. (2000)
    514. Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes. (PubMed id 17197413)1, 9 Butty V....Mathis D. (2007)
    515. Expression of CD28 and cytotoxic T lymphocyte antigen 4 at the maternal-fetal interface in women with unexplained pregnancy loss. (PubMed id 16564528)1, 9 Wang X....Lin Q. (2006)
    516. Schistosoma mansoni PIII antigen modulates in vitro granuloma formation by regulating CD28, CTLA-4, and CD86 expression in humans. (PubMed id 15019278)1, 9 Zouain C.S....Goes A.M. (2004)
    517. Association of CTLA-4 polymorphism with positive anti-GAD antibody in Japanese subjects with type 1 diabetes mellitus. (PubMed id 10619986)4, 9 Hayashi H....Ishikawa S.E. (1999)
    518. CTLA4 polymorphisms in Spanish patients with rheumatoid arthritis. (PubMed id 10203024)4, 9 Gonzalez-Escribano M.F....Nunez-Roldan A. (1999)
    519. B70 antigen is a second ligand for CTLA-4 and CD28. (PubMed id 7694153)1, 9 Azuma M....Somoza C. (1993)
    520. Abnormal CTLA-4 function in T cells from patients wit h systemic lupus erythematosus. (PubMed id 19950182)1, 9 Jury E.C....Ehrenstein M.R. (2010)
    521. Association Between Serum IgE Levels and the CTLA4 +4 9A/G and FCER1B -654C/T Polymorphisms in Korean Children With Asthma. (PubMed id 20358027)1, 9 Oh K.Y....Hong S.J. (2010)
    522. A functional soluble form of CTLA-4 is present in the serum of celiac patients and correlates with mucosal injury. (PubMed id 19625381)1, 9 Simone R....Saverino D. (2009)
    523. The CD4+CD25 bright regulatory T cells and CTLA-4 exp ression in peripheral and decidual lymphocytes are down-regulated in human misc arriage. (PubMed id 19766059)1, 9 Jin L.P....Li D.J. (2009)
    524. Genetic polymorphisms in cytotoxic T-lymphocyte antig en 4 and cancer: the dialectical nature of subtle human immune dysregulation. (PubMed id 19638588)1, 9 Sun T....Lin D. (2009)
    525. An African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans. (PubMed id 19300490)4, 9 Kelley J.M....Bridges S.L. (2009)
    526. Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabe tes. (PubMed id 19547759)1, 9 A8uczyA8ski W....GA^rska M. (2009)
    527. Association of CT60 polymorphism of the CTLA4 gene with Graves' disease in Taiwanese children. (PubMed id 18780601)1, 9 Tsai S.T....Lee Y.J. (2008)
    528. [Studies on the genetic pathogenesis of myasthenia gravis caused by CTLA-4 gene polymorphism.] (PubMed id 15583985)4, 9 Mao H.T....Gu H.T. (2004)
    529. High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy. (PubMed id 15610849)1, 9 Huxley P....Classon B.J. (2004)
    530. Involvement of CTLA-4 in T-cell anergy induced by sta phylococcal enterotoxin A in vitro. (PubMed id 15140570)1, 9 Xu G.L....Wu Y.Z. (2004)
    531. CTLA4 gene polymorphisms are associated with, and linked to, insulin-dependent diabetes mellitus in a Russian population. (PubMed id 11286636)1, 9 Chistiakov D.A....Nosikov V.V. (2001)
    532. Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. (PubMed id 11279502)1, 9 Stamper C.C....Mosyak L. (2001)
    533. Association of CTLA-4 gene A/G polymorphism in Japanese type 1 diabetic patients with younger age of onset and autoimmune thyroid disease. (PubMed id 10895849)4, 9 Takara M....Takasu N. (2000)
    534. Lack of a strong association of CTLA-4 exon 1 polymorphism with the susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese: an association study using a novel variation screening method. (PubMed id 10674972)4, 9 Matsushita M....Tokunaga K. (1999)
    535. CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis. (PubMed id 10082437)4, 9 Harbo H.F....Spurkland A. (1999)
    536. No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies. (PubMed id 9861324)4, 9 Heward J.M....Gough S.C. (1998)
    537. CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. (PubMed id 8989248)4, 9 Donner H....Badenhoop K. (1997)
    538. Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease. (PubMed id 9398726)4, 9 Donner H....Badenhoop K. (1997)
    539. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. (PubMed id 7807015)1, 9 Schneider H....Rudd C.E. (1995)
    540. Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail. (PubMed id 7559643)1, 9 Leung H.T....Linsley P.S. (1995)
    541. Cytotoxic T lymphocyte antigen-4 Ala17 polymorphism i s a genetic marker of autoimmune adrenal insufficiency: Italian association stu dy and meta-analysis of European studies. (PubMed id 19884265)1, 9 Brozzetti A....Falorni A. (2010)
    542. CTLA-4 A49G gene polymorphism is not associated with vitiligo in South Indian population. (PubMed id 20418973)1, 9 Deeba F....Rao H. (2010)
    543. CTLA4 targeting strategy in DNA vaccination against periodontitis. (PubMed id 18783892)1, 9 Yu F....Chen W. (2009)
    544. CTLA4 silencing with siRNA promotes deviation of Th1/Th2 in chronic hepatitis B patients. (PubMed id 19403062)1, 9 Yu Y....Zang G. (2009)
    545. Alpha-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis. (PubMed id 18545145)1, 9 Oble D.A....Lauwers G.Y. (2008)
    546. Cytotoxic T lymphocyte associated antigen-4 exon 1 A/G polymorphism in Iranian patients with multiple sclerosis. (PubMed id 18705023)1, 9 Borhani Haghighi A....Nikseresht A.R. (2008)
    547. The 3' UTR of the human CTLA4 mRNA can regulate mRNA stability and translational efficiency. (PubMed id 18078835)1, 9 Malquori L....Ruberti G. (2008)
    548. [Expressions of Fas, CTLA-4 and RhoBTB2 genes in breast carcinoma and their relationship with clinicopathological factors] (PubMed id 19173804)1, 9 Bi Y....Zuo W.S. (2008)
    549. CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization. (PubMed id 18095376)1, 9 Schneider H....Rudd C.E. (2008)
    550. [Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms with susceptibility to breast cancer.] (PubMed id 18328194)1, 9 Li H....Li D.J. (2008)
    551. Possible association of CTLA-4 gene polymorphism with cyclosporine-induced gingival overgrowth in kidney transplant recipients. (PubMed id 18021981)1, 9 Kusztal M....Klinger M. (2007)
    552. ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. (PubMed id 17875758)1, 9 Joshi A.D....Joshi S.S. (2007)
    553. Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations. (PubMed id 17938902)1, 9 Lan Q....Yeager M. (2007)
    554. Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86. (PubMed id 16708397)1, 9 Manzotti C.N....Sansom D.M. (2006)
    555. Reversal of the TCR stop signal by CTLA-4. (PubMed id 16931720)1, 9 Schneider H....Rudd C.E. (2006)
    556. Exon-3 polymorphism of CTLA-4 gene in Turkish patients with vitiligo. (PubMed id 15888380)1, 9 Itirli G....Pehlivan S. (2005)
    557. The CTLA4 +49 A/G*G-CT60*G haplotype is associated with susceptibility to multiple sclerosis in Flanders. (PubMed id 15904974)1, 9 Suppiah V....Vandenbroeck K. (2005)
    558. Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression. (PubMed id 15994283)1, 9 Tan P.H....George A.J. (2005)
    559. CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. (PubMed id 16227604)1, 9 Parry R.V....Riley J.L. (2005)
    560. HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity? (PubMed id 16229750)1, 9 Brand O....Heward J. (2005)
    561. Conversion of CTLA-4 from inhibitor to activator of T cells with a bispecific tandem single-chain Fv ligand. (PubMed id 15128776)1, 9 Madrenas J....Ling V. (2004)
    562. The emerging role of the CTLA-4 gene in autoimmune endocrinopathies. (PubMed id 15132716)1, 9 Vaidya B. and Pearce S. (2004)
    563. Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement mediate T cell unresponsiveness in patients with paracoccidioidomycosis. (PubMed id 12717632)1, 9 Campanelli A.P....Silva J.S. (2003)
    564. CTLA-4 in filarial infections: implications for a role in diminished T cell reactivity. (PubMed id 12574361)1, 9 Steel C. and Nutman T.B. (2003)
    565. Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients. (PubMed id 12838528)1, 9 Alizadeh M....Semana G. (2003)
    566. CTLA-4. FasL induces alloantigen-specific hyporesponsiveness. (PubMed id 12794109)1, 9 Elhalel M.D....Tykocinski M.L. (2003)
    567. CTLA-4 and its role in autoimmune thyroid disease. (PubMed id 12914522)1, 9 Chistiakov D.A. and Turakulov R.I. (2003)
    568. Increased expression of soluble cytotoxic T-lymphocyte-associated antigen-4 molecule in patients with systemic lupus erythematosus. (PubMed id 12791095)1, 9 Liu M.F....Fung L.L. (2003)
    569. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. (PubMed id 12826605)1, 9 Phan G.Q....Rosenberg S.A. (2003)
    570. A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele. (PubMed id 12244107)1, 9 Anjos S....Polychronakos C. (2002)
    571. Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence. (PubMed id 12225905)1, 9 Wang X.B....Lefvert A.K. (2002)
    572. Identification of an alternatively spliced variant of human CD86 mRNA. (PubMed id 11162656)1, 9 Magistrelli G....Delneste Y. (2001)
    573. Technical note: linkage disequilibrium and disease-associated CTLA4 gene polymorphisms. (PubMed id 11509583)4, 9 Holopainen P.M. and Partanen J.A. (2001)
    574. Association analysis of the cytotoxic T lymphocyte antigen-4 (CTLA-4) and autoimmune regulator-1 (AIRE-1) genes in sporadic autoimmune Addison's disease. (PubMed id 10690877)4, 9 Vaidya B....Pearce S.H. (2000)
    575. A native soluble form of CTLA-4. (PubMed id 10831323)1, 9 Oaks M.K....Tector A.J. (2000)
    576. Cutting edge: a soluble form of CTLA-4 in patients with autoimmune thyroid disease. (PubMed id 10799854)1, 9 Oaks M.K. and Hallett K.M. (2000)
    577. Polymorphisms in CTLA-4 but not tumor necrosis factor-alpha or interleukin 1beta genes are associated with Wegener's granulomatosis. (PubMed id 10685804)4, 9 Huang D....Lefvert A.K. (2000)
    578. Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms and susceptibility to type 1 autoimmune hepatitis. (PubMed id 10613727)4, 9 Agarwal K....Donaldson P.T. (2000)
    579. Lack of association between CD28/CTLA-4 gene polymorphisms and atopic asthma in the Japanese population. (PubMed id 11096256)4, 9 Nakao F....Hara T. (2000)
    580. The CTLA-4 gene is associated with multiple sclerosis. (PubMed id 10408973)4, 9 Ligers A....Olerup O. (1999)
    581. Cytotoxic T lymphocyte antigen 4 (CTLA-4) dimorphism in patients with systemic lupus erythematosus. (PubMed id 10609073)4, 9 Pullmann R....Hyrdel R. (1999)
    582. The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus. (PubMed id 10369864)1, 9 Vaidya B....Pearce S.H. (1999)
    583. No major role for the CTLA-4 gene in the association of autoimmune thyroid disease with IDDM. (PubMed id 9421385)4, 9 Djilali-Saiah I....Caillat-Zucman S. (1998)
    584. Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population. (PubMed id 9421386)4, 9 Awata T....Katayama S. (1998)
    585. A study of the association between a polymorphism in the CTLA-4 gene and postpartum thyroiditis. (PubMed id 9828915)4, 9 Waterman E.A....Weetman A.P. (1998)
    586. CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. The Belgian Diabetes Registry. (PubMed id 9353155)4, 9 Van der Auwera B.J....Gorus F.K. (1997)
    587. CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese. (PubMed id 9459626)4, 9 Yanagawa T....Saruta T. (1997)
    588. CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population. (PubMed id 7829637)4, 9 Yanagawa T....DeGroot L.J. (1995)
    589. Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28. (PubMed id 7545666)1, 9 Peach R.J....Linsley P.S. (1995)
    590. Overexpression and secretion of the soluble CTLA-4 spl ice variant in various autoimmune diseases and in cases with overlapping autoimm unity. (PubMed id 23448385)1 AlFadhli S. (2013)
    591. Melanoma immunotherapy: historical precedents, recent successes and future prospects. (PubMed id 23413908)1 Raaijmakers M.I....Levesque M.P. (2013)
    592. CTLA-4 -1722T/C polymorphism and systemic lupus erythe matosus susceptibility: a meta-analysis involving ten separate studies. (PubMed id 23323522)1 Zhu J.M....Ye D.Q. (2013)
    593. The associations between the polymorphisms in the CTLA -4 gene and the risk of Graves' disease in the Chinese population. (PubMed id 23597029)1 Du L....Huang J. (2013)
    594. The soluble isoform of CTLA-4 as a regulator of T-cell responses. (PubMed id 23400950)1 Ward F.J....Barker R.N. (2013)
    595. CTLA-4 polymorphisms and systemic lupus erythematosus: a comprehensive meta-analysis. (PubMed id 23289635)1 Liu J. and Zhang H.X. (2013)
    596. Post-transcriptional control of candidate risk genes f or type 1 diabetes by rare genetic variants. (PubMed id 22932817)1 de Jong V.M....Koeleman B.P. (2013)
    597. Pancreatic tumors and immature immunosuppressive myelo id cells in blood and spleen: role of inhibitory co-stimulatory molecules PDL1 a nd CTLA4. An in vivo and in vitro study. (PubMed id 23359812)1 Basso D....Plebani M. (2013)
    598. -1722T/C polymorphism (rs733618) of CTLA-4 significant ly associated with systemic lupus erythematosus (SLE): a comprehensive meta-anal ysis. (PubMed id 23261408)1 Liu J. and Zhang H. (2013)
    599. A molecular insight of CTLA-4 in food allergy. (PubMed id 23254121)1 Kumar S....Dwivedi P.D. (2013)
    600. Association between cytotoxic T lymphocyte antigen-4 p olymorphism and type 1 diabetes: a meta-analysis. (PubMed id 23261825)1 Chen Z....Wang X. (2013)
    601. Recipient cytotoxic T lymphocyte antigen 4 +49 single- nucleotide polymorphism is not associated with acute rejection after liver trans plantation in Chinese population. (PubMed id 23372431)1 Jiang Z....Zheng S. (2013)
    602. The CTLA-4 +49 A/G, CT60 A/G and PTPN22 1858 C/T polym orphisms and susceptibility to vitiligo: a meta-analysis. (PubMed id 23264102)1 Song G.G....Lee Y.H. (2013)
    603. Frequency and expression of inhibitory markers of CD4( +) CD25(+) FOXP3(+) regulatory T cells in patients with common variable immunode ficiency. (PubMed id 23432692)1 Arandi N....Aghamohammadi A. (2013)
    604. Impaired proteasome function activates GATA3 in T cell s and upregulates CTLA-4: relevance for Sezary syndrome. (PubMed id 22951729)1 Gibson H.M....Wong H.K. (2013)
    605. Intracellular CTLA4 and regulatory T cells in patients with laryngeal squamous cell carcinoma. (PubMed id 23252863)1 Erfani N....Ghaderi A. (2013)
    606. Role of the crosstalk between CTLA-4 and NKG2D in the development of anti-CTLA-4 treatment strategies. (PubMed id 23413900)1 Demaria S. and Dustin M.L. (2013)
    607. Association of CTLA-4 polymorphisms with improved over all survival in melanoma patients treated with CTLA-4 blockade: a pilot study. (PubMed id 23641913)1 Queirolo P....Pistillo M.P. (2013)
    608. Expression of cytotoxic T lymphocyte antigen-4 in T ce lls from children with Hashimoto's thyroiditis. (PubMed id 22836632)1 Kucharska A.M....Demkow U. (2013)
    609. Functional genetic variants of CTLA-4 and risk of toba cco-related oral carcinoma in high-risk North Indian population. (PubMed id 23246583)1 Bharti V....Das S.N. (2013)
    610. Analysis of cytotoxic T lymphocyte antigen-4 (CTLA-4) promoter -318C/T and +49A/G gene polymorphisms in Turkish patients with familial Mediterranean fever. (PubMed id 22923220)1 Gunesacar R....Dinkci S. (2013)
    611. Association of CTLA4 gene polymorphisms with susceptib ility and pathology correlation to pulmonary tuberculosis in Southern Han Chines e. (PubMed id 22811616)1 Wang C....Li J.C. (2012)
    612. Association between CTLA-4 exon-1 +49A/G polymorphism and systemic lupus erythematosus: an updated analysis. (PubMed id 22718509)1 Chang W.W....Su H. (2012)
    613. Increased production of circulating soluble co-stimula tory molecules CTLA-4, CD28 and CD80 in patients with rheumatoid arthritis. (PubMed id 22917707)1 Cao J....Zhang L. (2012)
    614. A pilot study on cytotoxic T lymphocyte-4 gene polymor phisms in urinary schistosomiasis. (PubMed id 22288822)1 Idris Z.M....Noordin R. (2012)
    615. CTLA-4 and TNF-a promoter-308 A/G polymorphisms and AN CA-associated vasculitis susceptibility: a meta-analysis. (PubMed id 21553055)1 Lee Y.H....Song G.G. (2012)
    616. Three different classifications, B lymphocyte subpopul ations, TNFRSF13B (TACI), TNFRSF13C (BAFF-R), TNFSF13 (APRIL) gene mutations, CT LA-4 and ICOS gene polymorphisms in Turkish patients with common variable immuno deficiency. (PubMed id 22699762)1 Kutukculer N....Berdeli A. (2012)
    617. The impact of rs231775 (+49AG) CTLA4 gene polymorphism on transplanted kidney function. (PubMed id 23018253)1 Domanski L....Ciechanowski K. (2012)
    618. Genotypes in relation to phenotypic appearance and exp osure to environmental factors in Graves' hyperthyroidism. (PubMed id 22968483)1 Vos X.G....Wiersinga W.M. (2012)
    619. CTLA-4 blockade with ipilimumab: long-term follow-up o f 177 patients with metastatic melanoma. (PubMed id 22271879)1 Prieto P.A....Phan G.Q. (2012)
    620. Low expression and secretion of circulating soluble CT LA-4 in peripheral blood mononuclear cells and sera from type 1 diabetic childre n. (PubMed id 22218756)1 Ryden A....Faresjo M. (2012)
    621. Cytotoxic T-lymphocyte antigen-4 polymorphisms and sus ceptibility to Ewing's sarcoma. (PubMed id 22905924)1 Yang S....Gao S. (2012)
    622. Polymorphisms in the CTLA-4 gene and rheumatoid arthri tis susceptibility: a meta-analysis. (PubMed id 22354566)1 Li X....Xiao X. (2012)
    623. Association of CTLA-4 (+49A/G) gene polymorphism with type 1 diabetes mellitus in Egyptian children. (PubMed id 21615267)1 Mosaad Y.M....El-Deek B.S. (2012)
    624. Association of genetic variation in co-stimulatory mol ecule genes with outcome of liver transplant in Iranian patients. (PubMed id 22579879)1 Karimi M.H....Nikeghbalian S. (2012)
    625. Inhibitory receptors are expressed by Trypanosoma cruz i-specific effector T cells and in hearts of subjects with chronic Chagas disease. (PubMed id 22574131)1 Arguello R.J....Laucella S.A. (2012)
    626. Human CD19(+)CD25(high) B regulatory cells suppress pr oliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regul atory cells. (PubMed id 22155204)1 Kessel A....Toubi E. (2012)
    627. IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-in dependent, IL-2-dependent manner from Th2 effectors during chronic inflammation. (PubMed id 22547705)1 Altin J.A....Cook M.C. (2012)
    628. Polymorphisms in cytotoxic T lymphocyte associated ant igen-4 influence the rate of acute rejection after renal transplantation in 167 Chinese recipients. (PubMed id 22418270)1 Gao J.W....Zhang F. (2012)
    629. The functional cytotoxic T lymphocyte-associated Prote in 4 49G-to-A genetic variant and risk of pancreatic cancer. (PubMed id 22359319)1 Yang M....Yu D. (2012)
    630. The CTLA-4 +49 A/G and -318 C/T polymorphisms and susc eptibility to asthma: a meta-analysis. (PubMed id 22707194)1 Lee Y.H....Song G.G. (2012)
    631. Cytotoxic T-lymphocyte associated antigen 4 polymorphi sms and asthma risk: a meta-analysis. (PubMed id 22844542)1 Nie W....Xiu Q. (2012)
    632. [Association of cytotoxic T lymphocyte-associated anti gen-4+49A/G polymorphism with childhood type 1 diabetes mellitus: a meta-analysi s]. (PubMed id 22989439)1 Luo S.Y....Chen Y.X. (2012)
    633. Association between CTLA4 gene polymorphisms and acute rejection of kidney transplantation: a meta-analysis. (PubMed id 22307437)1 Duan Z....Gao J. (2012)
    634. Association of CTLA-4 and TNF-a polymorphism with recu rrent miscarriage among North Indian women. (PubMed id 22727980)1 Gupta R....Agrawal S. (2012)
    635. Cytotoxic T-lymphocyte associated antigen-4 gene polym orphisms and primary biliary cirrhosis: a systematic review. (PubMed id 22414241)1 Li M....Liu D.W. (2012)
    636. A secreted protein microarray platform for extracellul ar protein interaction discovery. (PubMed id 21982860)1 Ramani S.R....Gonzalez L.C. (2012)
    637. Polymorphisms in the cytotoxic T-lymphocyte antigen 4 gene and acute rejection risk in transplant recipients. (PubMed id 22711308)1 Zhu C.L....Xie F. (2012)
    638. Association of CTLA-4 gene polymorphisms with sporadic breast cancer risk and clinical features in Han women of northeast China. (PubMed id 22249287)1 Li D....Pang D. (2012)
    639. Effects of different up-dosing regimens for hymenopter a venom immunotherapy on serum CTLA-4 and IL-10. (PubMed id 22723841)1 Riccio A.M....Passalacqua G. (2012)
    640. Gene-gene interactions between candidate gene polymorp hisms are associated with total IgE levels in Korean children with asthma. (PubMed id 22376040)1 Choi W.A....Hong S.J. (2012)
    641. Association of cytotoxic T-lymphocyte associated antig en 4 gene polymorphism with type 1 diabetes mellitus: a meta-analysis. (PubMed id 22964358)1 Tang S.T....Peng W.J. (2012)
    642. Association between the CTLA-4 +49 A/G polymorphism an d susceptibility to rheumatoid arthritis: a meta-analysis. (PubMed id 22179750)1 Lee Y.H....Song G.G. (2012)
    643. Dysregulated expression of both the costimulatory CD28 and inhibitory CTLA-4 molecules in PB T cells of advanced cervical cancer patie nts suggests systemic immunosuppression related to disease progression. (PubMed id 22094905)1 Kosmaczewska A....Frydecka I. (2012)
    644. Lack of association between CTLA-4 +49A/G and -318C/T polymorphisms and Behcet's disease risk: a meta-analysis. (PubMed id 23010350)1 Zhang Y.J....Ye D.Q. (2012)
    645. Recipient CTLA-4*CT60-AA genotype is a prognostic fact or for acute graft-versus-host disease in hematopoietic stem cell transplantatio n for thalassemia. (PubMed id 22245568)1 Orru S....La Nasa G. (2012)
    646. [Correlation between CTLA-4 gene polymorphism and syst emic lupus erythematosus: a meta-analysis]. (PubMed id 23232526)1 Chen S.L....Meng W. (2012)
    647. FOXP3, CBLB and ITCH gene expression and cytotoxic T l ymphocyte antigen 4 expression on CD4(+) CD25(high) T cells in multiple sclerosi s. (PubMed id 23039885)1 Sellebjerg F....Sorensen P.S. (2012)
    648. Constitutive clathrin-mediated endocytosis of CTLA-4 p ersists during T cell activation. (PubMed id 22262842)1 Qureshi O.S....Sansom D.M. (2012)
    649. sCTLA-4, CD4+CD25+Foxp3+ regulatory T cells in Behcet' s disease patients. (PubMed id 23010434)1 Demir N....Godekmerdan A. (2012)
    650. Cutting edge: cell-extrinsic immune regulation by CTLA -4 expressed on conventional T cells. (PubMed id 22753931)1 Wang C.J....Walker L.S. (2012)
    651. Association between the CTLA-4 +49A/G polymorphism and type 1 diabetes: a meta-analysis. (PubMed id 23009570)1 Si X....Tang W. (2012)
    652. Evaluation of CTLA-4 expression and relevance as a nov el prognostic factor in patients with non-small cell lung cancer. (PubMed id 22318401)1 Salvi S....Pistillo M.P. (2012)
    653. CTLA-4 polymorphisms and susceptibility to Behcet's di sease: a meta-analysis. (PubMed id 22722994)1 Lee Y.H. and Song G.G. (2012)
    654. CD40 C/T(-1) and CTLA-4 A/G(49) SNPs are associated wi th autoimmune thyroid diseases in the Chinese population. (PubMed id 21866398)1 Yang J....Zhang J.A. (2012)
    655. Genetic polymorphisms and surface expression of CTLA-4 and PD-1 on T cells of silica-exposed workers. (PubMed id 22153879)1 Rocha M.C....Queiroz M.L. (2012)
    656. Genetic variation in donor CTLA-4 regulatory region is a strong predictor of outcome after allogeneic hematopoietic cell transplantati on for hematologic malignancies. (PubMed id 22178694)1 Jagasia M....Savani B.N. (2012)
    657. A soluble form of CTLA-4 is present in paediatric pati ents with acute lymphoblastic leukaemia and correlates with CD1d+ expression. (PubMed id 23049754)1 Simone R....Saverino D. (2012)
    658. CD40, CD45 CTLA-4 levels are elevated in healthy older adults. (PubMed id 22783574)1 Yalcin A.D....Terzioglu E. (2012)
    659. Influence of cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms in periodontitis. (PubMed id 22497911)1 Houshmand B....Hajilooi M. (2012)
    660. Variations in suppressor molecule ctla-4 gene are rela ted to susceptibility to multiple myeloma in a polish population. (PubMed id 21744007)1 Karabon L....Frydecka I. (2012)
    661. Polymorphisms in CTLA4 influence incidence of drug-ind uced liver injury after renal transplantation in Chinese recipients. (PubMed id 23300559)1 Guo Y....Guo F. (2012)
    662. CTLA-4 exon 1 +49A/G polymorphism is associated with r enal involvement in pediatric Henoch-Schonlein purpura. (PubMed id 22700162)1 Wang J.J....Zou L.P. (2012)
    663. Genetic variants of TNFa, IL10, IL1b, CTLA4 and TGFb1 modulate the indices of alcohol-induced liver injury in East Indian population. (PubMed id 22902304)1 Roy N....Chowdhury A. (2012)
    664. PDCD1 polymorphism amplifies the predisposing effect c onferred by CTLA4 polymorphism in chronic hepatitis B virus infection. (PubMed id 22342451)1 Zhang G....Liu Z. (2012)
    665. Correlations of CTLA-4 gene polymorphisms and hepatiti s C chronic infection. (PubMed id 22136395)1 Danilovic D.L....Marui S. (2012)
    666. Association between the polymorphism A/G at position 4 9 of exon 1 of the CTLA-4 gene and antithyroid antibody production in children w ith Hashimoto's thyroiditis. (PubMed id 22922453)1 Kucharska A.M....Demkow U. (2012)
    667. Cytotoxic T-lymphocyte antigen-4 +49G/A polymorphism a nd susceptibility to pancreatic cancer. (PubMed id 22011251)1 Lang C....Li S. (2012)
    668. [The role of co-inhibitory signals driven by CTLA-4 i n immune system]. (PubMed id 22027421)1 Olive D....NunA"s J.A. (2011)
    669. Cytotoxic T-lymphocyte antigen 4 gene +49A/G polymorph ism significantly associated with susceptibility to primary biliary cirrhosis: a meta-analysis. (PubMed id 22118691)1 Chen R.R....Fan D.M. (2011)
    670. Polymorphism analysis of the CTLA-4 gene in paracocci dioidomycosis patients. (PubMed id 21537684)1 Lozano V.F....Felipe M.S. (2011)
    671. Genetic variants in CTLA4 are strongly associated wit h alopecia areata. (PubMed id 21346773)1 John K.K....Betz R.C. (2011)
    672. Associations between cytotoxic T lymphocyte-associated antigen-4 polymorphisms and serum tumor necrosis factor-a and interferon-g leve ls in patients with chronic hepatitis B virus infection. (PubMed id 21847627)1 Han Q....Liu Z. (2011)
    673. Association of variants in MMEL1 and CTLA4 with rheum atoid arthritis in the Han Chinese population. (PubMed id 21784728)1 Danoy P....Xu H. (2011)
    674. Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells i n infants. (PubMed id 21934066)1 Rabe H....Rudin A. (2011)
    675. CTLA4 is expressed on mature dendritic cells derived from human monocytes and influences their maturation and antigen presentation. (PubMed id 21414236)1 Wang X.B....Lefvert A.K. (2011)
    676. Cell-autonomous and -non-autonomous roles of CTLA-4 i n immune regulation. (PubMed id 21723783)1 Wing K....Sakaguchi S. (2011)
    677. Th3 immune responses in the progression of leprosy vi a molecular cross-talks of TGF-I^, CTLA-4 and Cbl-b. (PubMed id 21807564)1 Kumar S....Rao D.N. (2011)
    678. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. (PubMed id 21474713)1 Qureshi O.S....Sansom D.M. (2011)
    679. Cytotoxic T-lymphocyte antigen-4 +49G/A polymorphism is associated with increased risk of osteosarcoma. (PubMed id 21453059)1 Wang W....Cao X. (2011)
    680. Interaction between CTLA4 gene and IBD5 locus in Hung arian Crohn's disease patients. (PubMed id 21519805)1 CsAPngei V....Melegh B. (2011)
    681. Genetic polymorphisms in CTLA4 and SLC4A2 are differen tially associated with the pathogenesis of primary biliary cirrhosis in Japanese patients. (PubMed id 21594562)1 Aiba Y....Ishibashi H. (2011)
    682. Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering. (PubMed id 21156796)2 Yu C....Davis S.J. (2011)
    683. Polymorphisms in the cytotoxic T-lymphocyte antigen 4 gene and cancer risk: a meta-analysis. (PubMed id 21387262)1 Zhang Y....Fan H. (2011)
    684. CTLA4 exon1 A49G polymorphism in Slovak patients with rheumatoid arthritis and Hashimoto thyroiditis-results and the review of the l iterature. (PubMed id 21503616)1 Benhatchi K....LazA_rovA! I. (2011)
    685. Analysis of CTLA4 gene variant in infertile Brazilian women with and without endometriosis. (PubMed id 21599853)1 Lerner T.G....Barbosa C.P. (2011)
    686. Association of CTLA4, CD28 and ICOS gene polymorphism s with clinicopathologic characteristics of childhood IgA nephropathy in Korean population. (PubMed id 21677403)1 Kim H.J....Hahn W.H. (2011)
    687. Cytotoxic T-lymphocyte antigen 4 haplotype correlates with relapse and survival after allogeneic hematopoietic SCT. (PubMed id 21170090)1 Murase M....Naoe T. (2011)
    688. CTLA-4, CD28, and ICOS gene polymorphism associations with non-small-cell lung cancer. (PubMed id 21669243)1 Karabon L....Frydecka I. (2011)
    689. Association of HLA class II alleles and CTLA-4 polymo rphism with type 1 diabetes. (PubMed id 21422625)1 Ei Wafai R.J....Fakhoury H. (2011)
    690. Association between CTLA-4 exon-1 +49A>G polymorph ism and primary biliary cirrhosis risk: a meta-analysis. (PubMed id 21722820)1 Huang Q....Yu J.H. (2011)
    691. Association between T-lymphocyte regulatory gene CTLA 4 single nucleotide polymorphism at position 49 in exon 1 and HLA-DRB1*08 in Ja panese patients with psoriasis vulgaris. (PubMed id 21316924)1 Muto M....Ichimiya M. (2011)
    692. Cytotoxic T-lymphocyte antigen-4 polymorphisms and su sceptibility to osteosarcoma. (PubMed id 21612409)1 Liu Y....Yuan W. (2011)
    693. Association between CTLA-4 polymorphisms and the susc eptibility to systemic lupus erythematosus and Graves' disease in Thai populati on. (PubMed id 22053592)1 Kimkong I....Hirankarn N. (2011)
    694. CTLA-4 exon 1 +49 polymorphism alone and in a haploty pe with -318 promoter polymorphism may confer susceptibility to chronic HBV inf ection in Chinese Han patients. (PubMed id 21161390)1 Duan S....Xing F. (2011)
    695. Association of CTLA4 gene polymorphisms with lymphati c filariasis in an East Malaysian population. (PubMed id 21513760)1 Idris Z.M....Noordin R. (2011)
    696. Association of cytotoxic T lymphocyte associated anti gen-4 gene (rs60872763) polymorphism with Crohn's disease and high levels of se rum sCTLA-4 in Crohn's disease. (PubMed id 21251066)1 Chen Z....Xia B. (2011)
    697. CTLA-4 gene polymorphism and the risk of systemic lup us erythematosus in the Chinese population. (PubMed id 21915163)1 Taha Khalaf A....Lei T.C. (2011)
    698. [Single nucleotide polymorphisms of CTLA4 gene and th eir association with human cervical cancer]. (PubMed id 21644231)1 Jiang L....Cheng Y.X. (2011)
    699. CTLA-4 +49A>G polymorphism is associated with advan ced non-small cell lung cancer prognosis. (PubMed id 21832820)1 Song B....Han J. (2011)
    700. Enhancement of anti-tumor immunity through local modul ation of CTLA-4 and GITR by dendritic cells. (PubMed id 22028176)1 Pruitt S.K....Nair S. (2011)
    701. [Association between CTLA-4 gene polymorphism and susc eptibility to cervical cancer]. (PubMed id 22340049)1 Li H....Lin D.X. (2011)
    702. Differences in allergen-induced T cell activation bet ween allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4. (PubMed id 21356099)1 Botturi K....Magnan A. (2011)
    703. Immunoregulatory gene polymorphisms in women with pre eclampsia. (PubMed id 21160481)1 Pendeloski K.P....Daher S. (2011)
    704. Haplotype analysis of CTLA4 gene and risk of esophage al squamous cell carcinoma in Anyang area of China. (PubMed id 21661409)1 Cheng X.L....Chen Z.P. (2011)
    705. CTLA-4 +49 A/G gene polymorphism in Croatian and Slov enian multiple sclerosis patients. (PubMed id 21797987)1 CizmareviA8 N.S....RistiA8 S. (2011)
    706. A genome-wide association study identifies two new ris k loci for Graves' disease. (PubMed id 21841780)1 Chu X....Song H.D. (2011)
    707. CTLA4 A49G polymorphism shows significant association with glioma risk in a Chinese population. (PubMed id 21165767)1 Wu Q....Lu D. (2011)
    708. Low CTLA-4 expression in CD4+ helper T-cells in patie nts with fulminant type 1 diabetes. (PubMed id 21620894)1 Haseda F....Hanafusa T. (2011)
    709. The regulated secretory pathway in CD4(+) T cells cont ributes to human immunodeficiency virus type-1 cell-to-cell spread at the virolo gical synapse. (PubMed id 21909273)1 Jolly C....Sattentau Q.J. (2011)
    710. [Expression and significance of gp96 and immune-relat ed gene CTLA-4, CD8 in lung cancer tissues]. (PubMed id 20704820)1 Zheng H....Wang X. (2010)
    711. Inducing CTLA-4-dependent immune regulation by select ive CD28 blockade promotes regulatory T cells in organ transplantation. (PubMed id 20371478)1 Poirier N....Vanhove B. (2010)
    712. The role of rheumatoid arthritis genetic susceptibili ty markers in the prediction of erosive disease in patients with early inflamma tory polyarthritis: results from the Norfolk Arthritis Register. (PubMed id 20219786)1 Plant D....Barton A. (2010)
    713. New insights of CTLA-4 into its biological function i n breast cancer. (PubMed id 20578982)1 Mao H....Qu X. (2010)
    714. CTLA-4 gene polymorphisms (-318C/T, +49A/G, +6230A/G) in Iranian patients with multiple sclerosis. (PubMed id 21131701)1 Heidari A....Amirzargar A.A. (2010)
    715. CTLA-4 is expressed by human monocyte-derived dendrit ic cells and regulates their functions. (PubMed id 20650297)1 Laurent S....Pistillo M.P. (2010)
    716. Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity. (PubMed id 20825955)1 Moriguchi M....Ikegami H. (2010)
    717. Circulating soluble CTLA-4 is related to inflammatory markers in the 70 year old population. (PubMed id 20331384)1 Sakthivel P....Lind L. (2010)
    718. Elevated mRNA levels of CTLA-4, FoxP3, and granzyme B in BAL, but not in blood, during acute rejection of lung allografts. (PubMed id 20633650)1 Madsen C.B....Ryder L.P. (2010)
    719. Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with idiopathic thrombocytopenic purpura in a Chinese population. (PubMed id 21034161)1 Li H....Yang R. (2010)
    720. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    721. CTLA-4 suppresses the pathogenicity of self antigen-s pecific T cells by cell-intrinsic and cell-extrinsic mechanisms. (PubMed id 20037585)1 Ise W....Murphy K.M. (2010)
    722. Domain metastability: a molecular basis for immunoglo bulin deposition? (PubMed id 20394753)1 Sonnen A.F....Gilbert R.J. (2010)
    723. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    724. (AT) repeat in the 3' untranslated region of the CTLA -4 gene and susceptibility to acute allograft rejection in Tunisian renal trans plantation. (PubMed id 21168689)1 Krichen H....Gorgi Y. (2010)
    725. [Association of CTLA4 gene +49G/A polymorphism with H BV infection and HBV-related hepatocellular carcinoma in Hunan Han population]. (PubMed id 20813679)1 Liu G. and Lu G.X. (2010)
    726. Increased CTLA-4 and FOXP3 transcripts in peripheral blood mononuclear cells of patients with breast cancer. (PubMed id 20306312)1 Jaberipour M....Ghaderi A. (2010)
    727. CTLA4 polymorphisms and COPD. (PubMed id 20123855)1 Wood A.M....Stockley R.A. (2010)
    728. Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythema tosus. (PubMed id 19758313)1 JAorvinen T.M....Saarialho-Kere U. (2010)
    729. Association of genetic polymorphisms and risk of late post-transplantation infection in pediatric heart recipients. (PubMed id 20869265)1 Ohmann E.L....Zeevi A. (2010)
    730. CTLA-4 confers a risk of recurrent schizophrenia, maj or depressive disorder and bipolar disorder in the Chinese Han population. (PubMed id 21040781)1 Liu J....Shi Y. (2010)
    731. Association of T-cell regulatory gene polymorphisms w ith oral squamous cell carcinoma. (PubMed id 20435510)1 KAommerer P.W....Al-Nawas B. (2010)
    732. Effect of donor CTLA-4 alleles and haplotypes on graf t-versus-host disease occurrence in Tunisian patients receiving a human leukocy te antigen-identical sibling hematopoietic stem cell transplant. (PubMed id 21081144)1 Sellami M.H....Hmida S. (2010)
    733. ICOS gene polymorphism may be associated with pemphig us. (PubMed id 21084022)1 Narbutt J....MA8ynarski W. (2010)
    734. Genetic polymorphisms of the T-cell coreceptors CD28 and CTLA-4 in Afro- and Euro-Brazilians. (PubMed id 20477885)1 Pincerati M.R....Petzl-Erler M.L. (2010)
    735. Analysis of Immune Regulatory Genes' Copy Number Vari ants in Graves' Disease. (PubMed id 21054240)1 Huber A.K....Tomer Y. (2010)
    736. CTLA-4, Position 49 A/G Polymorphism Associated with Coronary Artery Lesions in Kawasaki Disease. (PubMed id 21082224)1 Kuo H.C....Yang K.D. (2010)
    737. Polymorphisms of the CTLA4 gene and kidney transplant rejection in Korean patients. (PubMed id 20940051)1 Kim H.J....Chung J.H. (2010)
    738. Circulating soluble CTLA4 (sCTLA4) is elevated in pat ients with breast cancer. (PubMed id 20482250)1 Erfani N....Ghaderi A. (2010)
    739. A screen for endocytic motifs. (PubMed id 20214754)1 Kozik P....Robinson M.S. (2010)
    740. IL1/IL1 Ra, CTLA-4 and Apo1/Fas genes polymorphisms a nd susceptibility to IgA nephropathy in Tunisian patients. (PubMed id 21049406)1 Gorgi Y....Ayed K. (2010)
    741. CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease. (PubMed id 20732370)1 Liu Y....Zhang L. (2010)
    742. Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheuma toid arthritis in African Americans. (PubMed id 21120996)4 Hughes L.B....Bridges S.L. (2010)
    743. Synergistic inhibition of T-cell activation by a cell-permeable ZAP-70 mutant and ctCTLA-4. (PubMed id 19230824)1 Kim K.D....Lee S.K. (2009)
    744. HIV-1 mediated immune pathogenesis: spotlight on the role of viral protein R (Vpr). (PubMed id 19275586)1 Majumder B....Ayyavoo V. (2009)
    745. Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte a ntigen-4 and programmed death-1. (PubMed id 19505258)1 Babu S....Nutman T.B. (2009)
    746. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    747. Prevalence of asthmatic symptoms in Lebanese patients with type 1 diabetes and their unaffected siblings compared to age-matched controls. (PubMed id 19319467)4 Taleb N....Azar S.T. (2009)
    748. Remapping the type I diabetes association of the CTLA 4 locus. (PubMed id 19956097)1 Qu H.Q....Polychronakos C. (2009)
    749. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    750. Evidence for genetic association and interaction betw een the TYK2 and IRF5 genes in systemic lupus erythematosus. (PubMed id 19567624)4 Hellquist A....Kere J. (2009)
    751. The clinical utility of inhibiting CD28-mediated costimulation. (PubMed id 19426230)2 Linsley P.S. and Nadler S.G. (2009)
    752. Lentiviral gene transfer of CTLA4 generates B cells w ith reduced costimulatory properties. (PubMed id 19811307)1 Vogt B....Sheriff A. (2009)
    753. CTLA-4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the CNS. (PubMed id 18665147)1 Hodi F.S....Mihm M. (2008)
    754. CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion. (PubMed id 18523152)1 Kavanagh B....Fong L. (2008)
    755. Inflammatory gene haplotype-interaction networks invol ved in coronary collateral formation. (PubMed id 18612209)4 Zhang J....Doevendans P.A. (2008)
    756. CT60 A/G marker of the 3'-UTR of the CTLA4 gene and liver transplant. (PubMed id 18047932)1 Muro M....Alvarez-Lopez M.R. (2008)
    757. Human leukocyte antigen class I-restricted immunosuppression by human CD8+ regulatory T cells requires CTLA-4-mediated interaction with dendritic cells. (PubMed id 18817831)1 Jarvis L.B....Gaston J.S. (2008)
    758. Analysis of 45 candidate genes for disease modifying a ctivity in multiple sclerosis. (PubMed id 18563468)4 Ramagopalan S.V....Ebers G.C. (2008)
    759. CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients. (PubMed id 18256061)1 Botturi K....Magnan A. (2008)
    760. Immunomodulatory and osteogenic differentiation effects of mesenchymal stem cells by adenovirus-mediated coexpression of CTLA4Ig and BMP2. (PubMed id 17960657)1 Zhang X....Dai K. (2008)
    761. Human immunodeficiency virus (HIV) type 1 Vpr induces differential regulation of T cell costimulatory molecules: direct effect of Vpr on T cell activation and immune function. (PubMed id 17023015)1 Venkatachari N.J....Ayyavoo V. (2007)
    762. Donor CTLA-4 +49 A/G*GG genotype is associated with chronic GVHD after HLA-identical haematopoietic stem-cell transplantations. (PubMed id 18056853)1 Azarian M....Socie G. (2007)
    763. Diminished myelin-specific T cell activation associated with increase in CTLA4 and Fas molecules in multiple sclerosis patients treated with IFN-beta. (PubMed id 17970696)1 Hallal-Longo D.E....Santos L.M. (2007)
    764. Molecular determinants of inverse agonist activity of biologicals targeting CTLA-4. (PubMed id 17785798)1 Teft W.A. and Madrenas J. (2007)
    765. The CTLA-4 -1661A/G and -1772T/C dimorphisms in Japanese patients with systemic sclerosis. (PubMed id 17225925)1 Takeuchi F....Tanimoto K. (2007)
    766. Significance of CTLA-4 and CD14 genetic polymorphisms in clinical outcome after allogeneic stem cell transplantation. (PubMed id 17846597)1 Vannucchi A.M....Bosi A. (2007)
    767. [Role of CD28/CTLA-4 co-stimulators in immune pathoph ysiology of aplastic anemia] (PubMed id 18246813)1 He G.S....Wu X.J. (2007)
    768. Production and characterization of human CTLA4Ig expressed in transgenic rice cell suspension cultures. (PubMed id 17079164)1 Lee S.J....Kim D.I. (2007)
    769. Allelic variant in CTLA4 alters T cell phosphorylation patterns. (PubMed id 18000051)1 Maier L.M....Hafler D.A. (2007)
    770. Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus. (PubMed id 17712998)1 Lyssuk E.Y....Bykovskaia S.N. (2007)
    771. A molecular perspective of CTLA-4 function. (PubMed id 16551244)2 Teft W.A.... Madrenas J. (2006)
    772. Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes. (PubMed id 16614815)1 Hermann R....Ilonen J. (2006)
    773. Prolongation of renal allograft survival in rats by replication-defective recombinant adenovirus-mediated coexpression of CD40L and CTLA4Ig. (PubMed id 16797372)1 Tian P.X....Wu J. (2006)
    774. CTLA-4 overexpression inhibits T cell responses through a CD28-B7-dependent mechanism. (PubMed id 16818761)1 Engelhardt J.J....Allison J.P. (2006)
    775. The genetic contribution of CTLA-4 dimorphisms in promoter and exon 1 regions in Japanese patients with rheumatoid arthritis. (PubMed id 16641053)1 Takeuchi F....Matsuta K. (2006)
    776. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    777. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    778. CTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription. (PubMed id 16476059)1 Srahna M....Vandenberghe P. (2006)
    779. Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection. (PubMed id 17005693)1 Zaunders J.J....Kelleher A.D. (2006)
    780. Functional evaluation of the autoimmunity-associated CTLA4 gene: the effect of the (AT) repeat in the 3'untranslated region (UTR). (PubMed id 16891094)1 Anjos S.M. and Polychronakos C. (2006)
    781. Induction of IL-10 suppressors in lung transplant patients by CD4+25+ regulatory T cells through CTLA-4 signaling. (PubMed id 17015751)1 Bharat A....Mohanakumar T. (2006)
    782. Virus attachment and replication are promoted after acquisition of host CD28 and CD152 by HIV-1. (PubMed id 16136471)1 Giguere J.F....Tremblay M.J. (2005)
    783. CBLB variants in type 1 diabetes and their genetic interaction with CTLA4. (PubMed id 15629882)1 Bergholdt R....Pociot F. (2005)
    784. CTLA-4 overexpression in CD19+/CD5+ cells correlates with the level of cell cycle regulators and disease progression in B-CLL patients. (PubMed id 15549146)1 Kosmaczewska A....Frydecka I. (2005)
    785. Prevention of experimental autoimmune myocarditis by hydrodynamics-based naked plasmid DNA encoding CTLA4-Ig gene delivery. (PubMed id 16198253)1 Abe S....Aizawa Y. (2005)
    786. Association of CTLA4 polymorphism with regulatory T cell frequency. (PubMed id 15940668)1 Atabani S.F....Karp C.L. (2005)
    787. Anti-human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies. (PubMed id 15486062)1 May K.F....Liu Y. (2005)
    788. Genetic analysis of families with autoimmune diabetes and thyroiditis: evidence for common and unique genes. (PubMed id 15928253)1 Golden B....Tomer Y. (2005)
    789. Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice. (PubMed id 15494488)1 Hwang K.W....Alegre M.L. (2004)
    790. Association of the cytotoxic T lymphocyte-associated antigen 4 gene with type 1 diabetes: evidence for independent effects of two polymorphisms on the same haplotype block. (PubMed id 15579786)1 Anjos S.M....Polychronakos C. (2004)
    791. Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling. (PubMed id 12606712)1 Zhang X....Nathenson S.G. (2003)
    792. c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. (PubMed id 12582153)1 Goto E.... Hotta H. (2003)
    793. Dual effect of CD85/leukocyte Ig-like receptor-1/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells. (PubMed id 11751964)1 Saverino D....Ciccone E. (2002)
    794. Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. (PubMed id 11826754)1 Chang T.T....Sharpe A.H. (2002)
    795. CTLA-4 upregulation during aging. (PubMed id 12297345)1 Leng Q....Borkow G. (2002)
    796. Genetic approaches to the investigation of rheumatoid arthritis. (PubMed id 11981324)4 Barton A. and Ollier W. (2002)
    797. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    798. Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. (PubMed id 12195015)1 Riley J.L....Linsley P.S. (2002)
    799. Polymorphisms in immunoregulatory genes: towards individualized immunosuppressive therapy? (PubMed id 12083951)4 Daly A.K....Donaldson P.T. (2002)
    800. Cell surface expression of the HIV-1 envelope glycoproteins is directed from intracellular CTLA-4-containing regulated secretory granules. (PubMed id 12060749)1 Miranda L.R....Franzusoff A. (2002)
    801. Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes. (PubMed id 12135671)1 Miller R.E....Laughlin M.J. (2002)
    802. The APOE locus and the pharmacogenetics of lipid response. (PubMed id 11891412)4 Ordovas J.M. and Mooser V. (2002)
    803. Long-term therapy with recombinant human erythropoietin decreases percentage of CD152(+) lymphocytes in primary glomerulonephritis haemodialysis patients. (PubMed id 12032199)1 Trzonkowski P....Rutkowski B. (2002)
    804. Expression, refolding, purification, molecular characterization, crystallization, and preliminary X-ray analysis of the receptor binding domain of human B7-2. (PubMed id 12071705)1 Zhang X....Nathenson S.G. (2002)
    805. A CTLA-4 gene polymorphism at position -318 in the promoter region affects the expression of protein. (PubMed id 12058260)1 Wang X.B....Lefvert A.K. (2002)
    806. Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families. (PubMed id 11507694)4 Cox N.J....Concannon P. (2001)
    807. Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T- lymphocyte antigen 4 and CD28. (PubMed id 11583591)1 Follows E.R.... Abbott W.M. (2001)
    808. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. (PubMed id 11022011)4 Ober C....Cox N.J. (2000)
    809. Association of CTLA4 gene A-G polymorphism with type 1 diabetes in Chinese children. (PubMed id 10671941)4 Lee Y.J....Chang J.G. (2000)
    810. The CTLA4/CD28 gene region on chromosome 2q33 confers susceptibility to celiac disease in a way possibly distinct from that of type 1 diabetes and other chronic inflammatory disorders. (PubMed id 11098935)1 Naluai A.T....Wahlstrom J. (2000)
    811. The Nef protein of HIV-1 associates with rafts and primes T cells for activation. (PubMed id 10618429)1 Wang J.K....Trono D. (2000)
    812. Soluble CD86 is a costimulatory molecule for human T lymphocytes. (PubMed id 11021528)1 Jeannin P....Delneste Y. (2000)
    813. A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells. (PubMed id 10556814)1 Magistrelli G....Delneste Y. (1999)
    814. CTLA-4 and HLA gene susceptibility to thyroid-associated orbitopathy. (PubMed id 10577673)4 Buzzetti R....Cascino I. (1999)
    815. A structural explanation for the recognition of tyrosine-based endocytotic signals. (PubMed id 9812899)1 Owen D.J. and Evans P.R. (1998)
    816. CTLA-4 gene polymorphism is associated with predisposition to IDDM in a population from central Poland. (PubMed id 9690057)4 Krokowski M....Caillat-Zucman S. (1998)
    817. Immune cell signaling aberrations in human lupus. (PubMed id 9724847)1 Liossis S.N....Tsokos G.C. (1998)
    818. Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. (PubMed id 9175836)2 Shiratori T.... Saito T. (1997)
    819. Analysis of candidate genes for susceptibility to type I diabetes: a case-control and family-association study of genes on chromosome 2q31-35. (PubMed id 9166681)4 Owerbach D....Gabbay K.H. (1997)
    820. Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression. (PubMed id 9200449)1 Chuang E....Thompson C.B. (1997)
    821. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. (PubMed id 8638161)1 Marengere L.E....Mak T.W. (1996)
    822. Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule. (PubMed id 7513726)1 Chen C....Nabavi N. (1994)
    823. (PubMed id 18468488)2 
    824. CD152 (CTLA-4) determines CD4 T cell migration in vit ro and in vivo. (PubMed id 19479036)9 Knieke K....Brunner-Weinzierl M.C. (2009)
    825. Increased expression of CTLA-4 (CD152) by T and B lymphocytes in Wegener's granulomatosis. (PubMed id 11678911)9 Steiner K....Broker B.M. (2001)
    826. Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4. (PubMed id 10464177)9 Oki S....Azuma M. (1999)
    827. Diversity of clonal T cell proliferation is mediated by differential expression of CD152 (CTLA-4) on the cell surface of activated i ndividual T lymphocytes. (PubMed id 14500641)9 Maszyna F....Brunner-Weinzierl M.C. (2003)
    828. Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation. (PubMed id 10583602)9 Vandenborre K....Vandenberghe P. (1999)
    829. Characterization of CTLA-4 structure and expression on human T cells. (PubMed id 8397258)9 Lindsten T....Gray G.S. (1993)
    830. Expression of CTLA-4 by human monocytes. (PubMed id 11841692)9 Wang X.B....Lefvert A.K. (2002)
    831. Human CTLA-4 is expressed in situ on T lymphocytes in germinal centers, in cutaneous graft-versus-host disease, and in Hodgkin's disease. (PubMed id 9546357)9 Vandenborre K....Vandenberghe P. (1998)
    832. Multiple negative feedbacks on CD152 expression in allograft tolerance. (PubMed id 15665765)9 Tsai M.K....Lee P.H. (2005)
    833. Molecular characterization of CD28 and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) of woodchuck (Marmota monax). (PubMed id 12956876)9 Yang D....Lu M. (2003)
    834. Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells. (PubMed id 11046036)9 Iida T....Saito T. (2000)
    835. Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection. (PubMed id 10193417)9 Steiner K....Broker B.M. (1999)
    836. CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. (PubMed id 1281186)9 Freeman G.J....Reiser H. (1992)
    837. T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor. (PubMed id 17070077)9 Valk E....Schneider H. (2006)
    838. Soluble CTLA-4 in sera of patients with bronchial asthma. (PubMed id 15871446)9 Shi H.Z....Zhong X.N. (2005)
    839. Differential expression of CTLA-4 among T cell subsets. (PubMed id 15147348)9 Jago C.B....Lombardi G. (2004)
    840. Chimeric co-stimulatory molecules that selectively act through CD28 or CTLA-4 on human T cells. (PubMed id 12167647)9 Lazetic S....Punnonen J. (2002)
    841. A polymorphism in the human cytotoxic T-lymphocyte antigen 4 ( CTLA4) gene (exon 1 +49) alters T-cell activation. (PubMed id 11976786)9 Maurer M....Rieckmann P. (2002)
    842. Regulation of surface and intracellular expression of CTLA-4 on human peripheral T cells. (PubMed id 11696196)9 Wang X.B....Lefvert A.K. (2001)
    843. ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement. (PubMed id 11290772)9 Riley J.L....June C.H. (2001)
    844. CTLA-4 gene expression is influenced by promoter and exon 1 polymorphisms. (PubMed id 11426323)9 Ligers A....Hillert J. (2001)
    845. Expression and function of CTLA-4 in Th1 and Th2 cells. (PubMed id 9759851)9 Alegre M.L....Gajewski T.F. (1998)
    846. Characterization of oligomers induced by inverse agon ists of CTLA-4. (PubMed id 18634825)9 Teft W.A. and Madrenas J. (2008)
    847. Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. (PubMed id 18419049)9 Chin L.T....Liao S.K. (2008)
    848. CTLA-4 expressed by chemoresistant, as well as untreated, myeloid leukaemia cells can be targeted with ligands to induce apoptosis. (PubMed id 17367412)9 Laurent S....Pistillo M.P. (2007)
    849. Genetic variation in ICOS regulates mRNA levels of ICOS and splicing isoforms of CTLA4. (PubMed id 16996590)9 Kaartinen T....Partanen J. (2007)
    850. Site-directed in vitro immunization leads to a complete human monoclonal IgG4 lambda that binds specifically to the CDR2 region of CTLA-4 (CD152) without interfering the engagement of natural ligands. (PubMed id 17714596)9 Chin L.T....Chu C.H. (2007)
    851. CTLA-4 polymorphisms in allergy and asthma and the TH1/ TH2 paradigm. (PubMed id 15316504)9 Munthe-Kaas M.C....Undlien D.E. (2004)
    852. CTLA-4 (CD152) expression in peripheral blood T cells in Kawasaki disease. (PubMed id 12653853)9 Matsubara T....Furukawa S. (2003)
    853. CTLA-4 upregulation during HIV infection: association with anergy and possible target for therapeutic intervention. (PubMed id 11872994)9 Leng Q....Borkow G. (2002)
    854. Cytotoxic T lymphocyte antigen 4 gene polymorphism confers susceptibility to type 1 diabetes in Japanese children: analysis of association with HLA genotypes and autoantibodies. (PubMed id 11894970)9 Kikuoka N....Murata M. (2001)
    855. The comparative efficacy of CTLA-4 and L-selectin targeted DNA vaccines in mice and sheep. (PubMed id 11483267)9 Drew D.R....Strugnell R.A. (2001)
    856. CD85/LIR-1/ILT2 and CD152 (cytotoxic T lymphocyte antigen 4) inhibitory molecules down-regulate the cytolytic activity of human CD4+ T-cell clones specific for Mycobacterium tuberculosis. (PubMed id 11553539)9 Merlo A....Ciccone E. (2001)
    857. Expression of CTLA-4 molecule in peripheral blood T lymphocytes from patients with systemic lupus erythematosus. (PubMed id 9857283)9 Liu M.F....Lei H.Y. (1998)
    858. Accumulation of CTLA-4 expressing T lymphocytes in th e germinal centres of human lymphoid tissues. (PubMed id 9135556)9 Castan J....BrAPker B.M. (1997)
    859. Regulation of CTLA-4 expression during T cell activat ion. (PubMed id 8666782)9 Perkins D....Finn P.W. (1996)
    860. Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7. (PubMed id 7511623)9 Damle N.K....Linsley P.S. (1994)
    861. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. (PubMed id 1334116)9 Linsley P.S....Damle N.K. (1992)
    862. PD-1 and CTLA-4 combination blockade expands infiltra ting T cells and reduces regulatory T and myeloid cells within B16 melanoma tum ors. (PubMed id 20160101)9 Curran M.A....Allison J.P. (2010)
    863. Structure-Function analysis of the CTLA-4 interaction with PP2A. (PubMed id 19405949)9 Teft W.A....Madrenas J. (2009)
    864. CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation. (PubMed id 19462377)9 Sojka D.K....Fowell D.J. (2009)
    865. [Effects of dexamethasone on CTLA-4 expression and ap optosis in lymphocytes obtained from children with mesangial proliferative neph ritis] (PubMed id 20113596)9 Wang F.Y....Luo R.H. (2009)
    866. CTLA-4 . FasL induces early apoptosis of activated T cells by interfering with anti-apoptotic signals. (PubMed id 18025171)9 Orbach A....Dranitzki-Elhalel M. (2007)
    867. CTLA-4 lacking the cytoplasmic domain costimulates IL-2 production in T-cell hybridomas. (PubMed id 16405652)9 Hueber A.J....Nagel T. (2006)
    868. [The surface CD152 (CTLA-4) expression on peripheral blood lymphocytes in children with Hashimoto's thyroiditis] (PubMed id 17020649)9 Kucharska A....Rymkiewicz-Kluczynska B. (2006)
    869. CTLA-4 is constitutively expressed on tumor cells and can trigger apoptosis upon ligand interaction. (PubMed id 15912538)9 Contardi E....Pistillo M.P. (2005)
    870. CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function. (PubMed id 16126897)9 Schneider H....Rudd C.E. (2005)
    871. Expression of CTLA-4 (CD152) in peripheral blood T cells of children with influenza virus infection including encephalopathy in comparison with respiratory syncytial virus infection. (PubMed id 15196256)9 Ayukawa H....Furukawa S. (2004)
    872. Activity and safety of CTLA-4 blockade combined with vaccines in cynomolgus macaques. (PubMed id 14634142)9 Keler T....Korman A. (2003)
    873. CTLA-4 regulates cell cycle progression during a primary immune response. (PubMed id 11807776)9 Greenwald R.J....Sharpe A.H. (2002)
    874. Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function. (PubMed id 11733581)9 Martin M....Rudd C.E. (2001)
    875. Patients with neoplastic and nonneoplastic hematologic diseases acquire CTLA-4 antibodies after blood transfusion. (PubMed id 11316895)9 Pistillo M.P....Ferrara G.B. (2001)
    876. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. (PubMed id 10899917)9 Takahashi T....Sakaguchi S. (2000)
    877. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can regulate dendritic cell-induced activation and cytotoxicity of CD8(+) T cel ls independently of CD4(+) T cell help. (PubMed id 10190907)9 McCoy K.D....Ronchese F. (1999)
    878. Costimulatory markers in muscle of patients with idiopathic inflammatory myopathies and in cultured muscle cells. (PubMed id 10444360)9 Nagaraju K....Plotz P.H. (1999)
    879. Increased expression of down-regulatory CTLA-4 molecule on T lymphocytes from rheumatoid synovial compartment. (PubMed id 10404054)9 Liu M.F....Lei H.Y. (1999)
    880. CTLA4 gene polymorphism correlates with the mode of onset and presence of ICA512 Ab in Japanese type 1 diabetes. (PubMed id 10724097)9 Abe T....Eguchi K. (1999)
    881. Expression of CTLA-4 (CD152) on human medullary CD4+ thymocytes. (PubMed id 9749982)9 Castan J....BrAPker B.M. (1998)
    882. Activated T cells can induce high levels of CTLA-4 expression on B cells. (PubMed id 7543532)9 Kuiper H.M....van Lier R.A. (1995)
    883. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. (PubMed id 7543139)9 Krummel M.F. and Allison J.P. (1995)
    884. Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4). A disulfide-linked homodimer binds two CD86 molecules. (PubMed id 7541042)9 Linsley P.S....Brady W. (1995)
    885. Functional analysis of Foxp3 and CTLA-4 expressing HT LV-1-infected cells in a rat model. (PubMed id 19596078)9 Takayanagi R....Shida H. (2009)
    886. Regulatory effect of FK506 on CD152 and PD-1 in the liver allorecipients. (PubMed id 18589137)9 Li J....Wu H. (2008)
    887. A theoretical framework for quantitative analysis of the molecular basis of costimulation. (PubMed id 16034096)9 Jansson A....Nilsson P. (2005)
    888. Increased expression of plasma and cell surface co-stimulatory molecules CTLA-4, CD28 and CD86 in adult patients with allergic asthma. (PubMed id 15958078)9 Wong C.K....Lam C.W. (2005)
    889. B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse. (PubMed id 15357951)9 Pentcheva-Hoang T....Allison J.P. (2004)
    890. Analysis of the CTLA-4, CD28, and inducible costimulator (ICOS) genes in autoimmune thyroid disease. (PubMed id 14647199)9 Ban Y....Tomer Y. (2003)
    891. CTLA-4-Mediated inhibition of early events of T cell proliferation. (PubMed id 10229815)9 Brunner M.C....Allison J.P. (1999)
    892. The complexities of CD28 and CTLA-4 signalling: PI3K and beyond. (PubMed id 10202558)9 Ward S.G. (1999)
    893. Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4. (PubMed id 7544393)9 Fargeas C.A....SAckaly R.P. (1995)
    894. CTLA-4: a key regulatory point in the control of autoimmune disease. (PubMed id 18613834)9 Scalapino K.J. and Daikh D.I. (2008)
    895. CD28 downregulation on CD4+ T cells is associated with age of kidney transplant recipient. (PubMed id 18346013)9 Kusztal M....Klinger M. (2008)
    896. Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus. (PubMed id 16423064)9 Lee J.H....Chiang B.L. (2006)
    897. Cutting edge: monovalency of CD28 maintains the antigen dependence of T cell costimulatory responses. (PubMed id 16670276)9 Dennehy K.M....Hunig T. (2006)
    898. Insulin treatment in patients with type 1 diabetes induces upregulation of regulatory T-cell markers in peripheral blood mononuclear cells stimulated with insulin in vitro. (PubMed id 17130491)9 Tiittanen M....Vaarala O. (2006)
    899. Dysregulation of CD28 and CTLA-4 expression by CD4 T cells from previously immunodeficient HIV-infected patients with sustained virological responses to highly active antiretroviral therapy. (PubMed id 16011533)9 Stone S.F....French M.A. (2005)
    900. Relationship between CTLA-4 and CD28 molecule expression on T lymphocytes and stimulating and blocking autoantibodies to the TSH-receptor in children with Graves' disease. (PubMed id 16220002)9 Bossowski A....Urban M. (2005)
    901. CTLA4 gene polymorphism and autoimmunity. (PubMed id 15790353)9 Gough S.C....Sansom D.M. (2005)
    902. [Analysis of costimulatory molecules (CD28-CTLA-4/B7) expression on chosen mononuclear cells in adolescents with Graves' disease during methimazole therapy] (PubMed id 15504312)9 Bossowski A....Rinderle C. (2004)
    903. Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation. (PubMed id 15585834)9 Li D....Zhang J. (2004)
    904. Increased salivary gland tissue expression of Fas, Fas ligand, cytotoxic T lymphocyte-associated antigen 4, and programmed cell death 1 in primary Sjogren's syndrome. (PubMed id 12528117)9 Bolstad A.I....Jonsson R. (2003)
    905. The interaction properties of costimulatory molecules revisited. (PubMed id 12196291)9 Collins A.V....Davis S.J. (2002)
    906. [A linkage study of cytotoxic T lymphocyte-associated antigen 4 gene and Graves' disease in northern Chinese Han ethnic] (PubMed id 12654233)9 Jin Y....Huang W. (2002)
    907. IFN-beta1a modulates the expression of CTLA-4 and CD28 splice variants in human mononuclear cells: induction of soluble isoforms. (PubMed id 11710992)9 Giorelli M....Trojano M. (2001)
    908. Cell surface CD28 levels define four CD4+ T cell subsets: abnormal expression in rheumatoid arthritis. (PubMed id 11318597)9 Salazar-Fontana L.I....Alvarez-Mon M. (2001)
    909. Expression and functional significance of CTLA-4, a negative regulator of T cell activation. (PubMed id 11266089)9 Kosmaczewska A....Frydecka I. (2001)
    910. The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation. (PubMed id 10604992)9 Baroja M.L....Madrenas J. (2000)
    911. Expression of costimulatory molecules CD80 and CD86 and their receptors CD28, CTLA-4 on malignant ascites CD3+ tumour-infiltrating lymphocytes (TIL) from patients with ovarian and other types of peritoneal carcinomatosis. (PubMed id 10606960)9 Melichar B....Freedman R.S. (2000)
    912. Differential expression of costimulatory molecules in chronic inflammatory periodontal disease tissue. (PubMed id 9933436)9 Orima K....Hara K. (1999)
    913. [Regulation of T-cell activation by CD28 and CTLA-4] (PubMed id 9849050)9 Nagel T....Manger B. (1998)
    914. Molecular basis of T cell inactivation by CTLA-4. (PubMed id 9856951)9 Lee K.M....Bluestone J.A. (1998)
    915. CTLA4 codon 17 dimorphism in patients with rheumatoid arthritis. (PubMed id 9459504)9 Seidl C....Badenhoop K. (1998)
    916. A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with autoimmune Addison's disease in English patients. (PubMed id 10197076)9 Kemp E.H....Weetman A.P. (1998)
    917. The IgV domain of human B7-2 (CD86) is sufficient to co-stimulate T lymphocytes and induce cytokine secretion. (PubMed id 9199963)9 Rennert P....Gray G.S. (1997)
    918. In situ expression of B7 and CD28 receptor families in human malignant melanoma: relevance for T-cell-mediated anti-tumor immunity. (PubMed id 7543078)9 Denfeld R.W....Simon J.C. (1995)
    919. BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination. (PubMed id 20038811)9 DerrAc L....Speiser D.E. (2010)
    920. Mycobacterium bovis bacillus Calmette-Guerin treated human cord blood monocyte-derived dendritic cells polarize naA^ve T cells into a tolerogenic phenotype in newborns. (PubMed id 20127220)9 Liu E.M....Lau Y.L. (2010)
    921. CD4(+) T-cell activation is differentially modulated by bacteria-primed dendritic cells, but is generally down-regulated by n-3 poly unsaturated fatty acids. (PubMed id 19909377)9 Brix S....kiaer H. (2010)
    922. Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. (PubMed id 19247441)9 Nakamoto N....Chang K.M. (2009)
    923. Desmoglein 3-specific T regulatory 1 cells consist of two subpopulations with differential expression of the transcription factor Foxp3. (PubMed id 18800988)9 Veldman C....Hertl M. (2009)
    924. Are CD4+CD25-Foxp3+ cells in untreated new-onset lupu s patients regulatory T cells? (PubMed id 19821980)9 Yang H.X....Zhang X. (2009)
    925. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulato ry T cells expressing CTLA-4 and FoxP3. (PubMed id 19843932)9 Jeffery L.E....Sansom D.M. (2009)
    926. The inhibitory co-receptors: a way to save from anergy the HIV-specific T cells. (PubMed id 19442121)9 Simone R....Saverino D. (2009)
    927. CD4+ and CD8+ T cells expressing FoxP3 in HIV-infecte d patients are phenotypically distinct and influenced by disease severity and a ntiretroviral therapy. (PubMed id 19363449)9 Lim A....Price P. (2009)
    928. The Type I Diabetes Genetics Consortium 'Rapid Respon se' family-based candidate gene study: strategy, genes selection, and main outc ome. (PubMed id 19956109)9 Julier C....Pugliese A. (2009)
    929. Recent advances using anti-CTLA-4 for the treatment o f melanoma. (PubMed id 19556898)9 Sarnaik A.A. and Weber J.S. (2009)
    930. Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphoma. (PubMed id 18569641)9 Capriotti E....Hess A.D. (2008)
    931. DNA vaccines targeting tumor antigens to B7 molecules on antigen-presenting cells induce protective antitumor immunity and delay onset of HER-2/Neu-driven mammary carcinoma. (PubMed id 18980988)9 Sloots A....Wels W.S. (2008)
    932. Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. (PubMed id 18832734)9 Frommer F....Waisman A. (2008)
    933. Altered expression of the costimulatory molecules CD80, CD86, CD152, PD-1 and ICOS on T-cells from paracoccidioidomycosis patients: lack of correlation with T-cell hyporesponsiveness. (PubMed id 18757242)9 Cacere C.R....Benard G. (2008)
    934. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. (PubMed id 18759926)9 Fife B.T. and Bluestone J.A. (2008)
    935. CTLA-4 activation of phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death. (PubMed id 19052636)9 Schneider H....Rudd C.E. (2008)
    936. [Regulatory effect of FK506 on the expression of CD15 2 and PD-1 in the liver allo-recipients] (PubMed id 18177621)9 Li J....Wu H. (2008)
    937. Upregulation of molecules associated with T-regulatory function by thymoglobulin pretreatment of human CD4+ cells. (PubMed id 19034013)9 Liu Z....Xu H. (2008)
    938. Effect of house dust mite immunotherapy on transforming growth factor beta1-producing T cells in asthmatic children. (PubMed id 18450115)9 Ajduk J....Gagro A. (2008)
    939. SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade. (PubMed id 18303116)9 Fasso M....Allison J.P. (2008)
    940. Expression of surface markers on peripheral CD4+CD25high T cells in patients with atopic asthma: role of inhaled corticosteroid. (PubMed id 18298910)9 Zhang Q....Yin K.S. (2008)
    941. Special regulatory T cell review: The resurgence of the concept of contrasuppression in immunoregulation. (PubMed id 18154618)9 Lehner T. (2008)
    942. Deficiency of forkhead box P3 and cytotoxic T-lymphocyte-associated antigen-4 gene expressions and impaired suppressor function of CD4(+)CD25(+) T cells in patients with autoimmune hepatitis. (PubMed id 18624718)9 Okumura A....Kakumu S. (2008)
    943. Proportions of circulating T cells with a regulatory cell phenotype increase with HIV-associated immune activation and remain high on antiretroviral therapy. (PubMed id 17630546)9 Lim A....French M.A. (2007)
    944. [The implications of nasal associated lymphoid tissue in development of respiratory allergic diseases in children] (PubMed id 17625281)9 Zakrzewska A....GA^rski P. (2007)
    945. Differential inhibition of autoreactive memory- and alloreactive naive T cell responses by soluble cytotoxic T lymphocyte antigen 4 (sCTLA4), CTLA4Ig and LEA29Y. (PubMed id 17924973)9 Huurman V.A....Roep B.O. (2007)
    946. Paradoxical effect of reduced costimulation in T cell-mediated colitis. (PubMed id 17442938)9 Kim G....Kronenberg M. (2007)
    947. IMGT Colliers de Perles and IgSF domain standardization for T cell costimulatory activatory (CD28, ICOS) and inhibitory (CTLA4, PDCD1 and BTLA) receptors. (PubMed id 17391759)9 Garapati V.P. and Lefranc M.P. (2007)
    948. Potential role of CD4+CD25HIGH regulatory T cells in morbidity in Chagas disease. (PubMed id 17485260)9 Araujo F.F....Correa-Oliveira R. (2007)
    949. Evaluation of immunogenicity of the T cell costimulat ion modulator abatacept in patients treated for rheumatoid arthritis. (PubMed id 18050376)9 Haggerty H.G....Aranda R. (2007)
    950. Tremelimumab (CP-675,206), a cytotoxic T lymphocyte associated antigen 4 blocking monoclonal antibody in clinical development for patients with cancer. (PubMed id 17673618)9 Ribas A....Gomez-Navarro J. (2007)
    951. Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy for the treatment of prostate cancer. (PubMed id 16962497)9 Thompson R.H....Kwon E.D. (2006)
    952. Skin reactions in a subset of patients with stage IV melanoma treated with anti-cytotoxic T-lymphocyte antigen 4 monoclonal antibody as a single agent. (PubMed id 16490844)9 Jaber S.H....Hwang S.T. (2006)
    953. Biologic and immunomodulatory events after CTLA-4 blockade with ticilimumab in patients with advanced malignant melanoma. (PubMed id 16615096)9 Reuben J.M....Camacho L.H. (2006)
    954. Expression of Fas ligand and CTLA4 in adenoids has a predictive value for allergic rhinitis development in children. (PubMed id 16685136)9 Zakrzewska A....GA^rski P. (2006)
    955. Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation. (PubMed id 16604087)9 Choi J.M....Lee S.K. (2006)
    956. CD40L, CD28, and CTLA-4 expression on CD4+ T cells in kidney graft recipients: a relationship with post-transplantation clinical course. (PubMed id 16701174)9 Kosmaczewska A....Klinger M. (2006)
    957. Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity. (PubMed id 16754847)9 Jinushi M....Dranoff G. (2006)
    958. Phenotypic and genetic analyses of T-cell-mediated immunoregulation in patients with Type 1 diabetes. (PubMed id 16978382)9 Tsutsumi Y....Hara T. (2006)
    959. [Lymphocyte coreceptors] (PubMed id 17156728)9 Olive D. (2006)
    960. Mechanisms of CTLA-4-Ig in tolerance induction. (PubMed id 16454732)9 Alegre M.L. and Fallarino F. (2006)
    961. Genetic analysis and functional evaluation of the C/T(-318) and A/G(-1661) polymorphisms of the CTLA-4 gene in patients affected with Graves' disease. (PubMed id 16297665)9 Chistiakov D.A....Demurov L.M. (2006)
    962. Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation. (PubMed id 17028180)9 Chen C....Wells A.D. (2006)
    963. CD4+CD25+ regulatory T cells in patients with BehAset's disease. (PubMed id 17067431)9 Hamzaoui K....Houman H. (2006)
    964. Plasma concentrations of soluble CTLA-4, CD28, CD80 and CD86 costimulatory molecules reflect disease severity of acute asthma in children. (PubMed id 16703581)9 Ip W.K....Lam C.W. (2006)
    965. Allelic effects on gene regulation at the autoimmunity-predisposing CTLA4 locus: a re-evaluation of the 3' +6230G>A polymorphism. (PubMed id 15858600)9 Anjos S.M....Polychronakos C. (2005)
    966. Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. (PubMed id 16283570)9 Maker A.V....Rosenberg S.A. (2005)
    967. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. (PubMed id 16087944)9 Attia P....Rosenberg S.A. (2005)
    968. Aberrant production of soluble costimulatory molecules CTLA-4, CD28, CD80 and CD86 in patients with systemic lupus erythematosus. (PubMed id 15870153)9 Wong C.K....Lam C.W. (2005)
    969. The soluble CTLA-4 receptor: a new marker in autoimmune diseases. (PubMed id 16088318)9 Pawlak E....BiliA8ska M. (2005)
    970. Gene expression analysis of the CD4+ T-cell clones derived from gingival tissues of periodontitis patients. (PubMed id 16238600)9 Ito H....Yamazaki K. (2005)
    971. Ctla4 and multiple sclerosis in the Italian population. (PubMed id 15596061)9 Malferrari G....Biunno I. (2005)
    972. CTLA-4 blockade augments human T lymphocyte-mediated suppression of lung tumor xenografts in SCID mice. (PubMed id 15846492)9 Sabel M.S....Bankert R.B. (2005)
    973. Quantitative association tests of immune responses to antigens of Mycobacterium tuberculosis: a study of twins in West Africa. (PubMed id 15607008)9 Wiart A....Hill A.V. (2004)
    974. Genetic association of coeliac disease susceptibility to polymorphisms in the ICOS gene on chromosome 2q33. (PubMed id 14712308)9 Haimila K....Holopainen P. (2004)
    975. Two distinct pathways of immuno-modulation improve potency of p53 immunization in rejecting established tumors. (PubMed id 15289349)9 Daftarian P....Ellenhorn J.D. (2004)
    976. CD25+CD4+ regulatory T cells in patients with Kawasaki disease. (PubMed id 15343196)9 Furuno K....Hara T. (2004)
    977. Dominant expression of interleukin-10 and transforming growth factor-beta genes in activated T-cells of chronic active Epstein-Barr virus infection. (PubMed id 15368517)9 Ohga S....Hara T. (2004)
    978. [Surface expression of costimulatory molecules CD28/CTLA-4 on peripheral blood T lymphocytes in the course of type 1 diabetes mellitus in children and adolescents] (PubMed id 15504310)9 PawA8owski P....Stasiak-Barmuta A. (2004)
    979. Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis. (PubMed id 15534492)9 Robinson M.R....Rosenberg S.A. (2004)
    980. Altering immune tolerance therapeutically: the power of negative thinking. (PubMed id 14657212)9 Prud'homme G.J. (2004)
    981. Intracellular capture of B7 in antigen-presenting cells reduces costimulatory activity. (PubMed id 12589793)9 Sheriff A....Micheel B. (2003)
    982. Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity. (PubMed id 14515359)9 Tsaknaridis L....Vandenbark A.A. (2003)
    983. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. (PubMed id 12515820)9 Chikuma S....Bluestone J.A. (2003)
    984. CTLA-4 negative signaling via lipid rafts: A new pers pective. (PubMed id 11972356)9 Rudd C.E....Schneider H. (2002)
    985. Structural mechanisms of costimulation. (PubMed id 11976720)9 Schwartz J.C....Almo S.C. (2002)
    986. CTLA-4 blockade of antigen-induced cell death. (PubMed id 11159548)9 da Rocha Dias S. and Rudd C.E. (2001)
    987. Crystallization and preliminary X-ray analysis of the complex between human CTLA-4 and B7-2. (PubMed id 11375523)9 Zhang X....Almo S.C. (2001)
    988. Surgical and molecular approaches to the sentinel lymph nodes. (PubMed id 11599894)9 Essner R. and Kojima M. (2001)
    989. Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand. (PubMed id 10760791)9 Mages H.W....Kroczek R.A. (2000)
    990. Modulation of susceptibility to HIV-1 infection by the cytotoxic T lymphocyte antigen 4 costimulatory molecule. (PubMed id 10839813)9 Riley J.L....June C.H. (2000)
    991. The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A. (PubMed id 11021529)9 Chuang E....Thompson C.B. (2000)
    992. Activation of lymphocytes by BAT and anti CTLA-4: com parison of binding to T and B cells. (PubMed id 10482359)9 Raiter A....Hardy B. (1999)
    993. Molecular weights of CTLA-4 and CD80 by sedimentation equilibrium ultracentrifugation. (PubMed id 10334846)9 Fairman R....Shaw S.Y. (1999)
    994. Expression of the costimulator molecules, CD80, CD86, CD28, and CD152 on lymphocytes from neonates and young children. (PubMed id 10600000)9 Elliott S.R....Zola H. (1999)
    995. Detection of a soluble form of B7-1 (CD80) in synovial fluid from patients with arthritis using monoclonal antibodies against distinct epitopes of human B7-1. (PubMed id 9576010)9 McHugh R.S....Selvaraj P. (1998)
    996. Genetic association of Ctla-4 to myasthenia gravis with thymoma. (PubMed id 9688341)9 Huang D....Lefvert A.K. (1998)
    997. Localization in situ of costimulatory molecules and cytokines in B-cell non-Hodgkin's lymphoma. (PubMed id 9767448)9 Vyth-Dreese F.A....De Jong D. (1998)
    998. Synergistic effect between IL-10 and bcl-2 genotypes in determining susceptibility to systemic lupus erythematosus. (PubMed id 9550468)9 Mehrian R....Jacob C.O. (1998)
    999. A CTLA-4 gene polymorphism is associated with both Graves disease and autoimmune hypothyroidism. (PubMed id 9231050)9 Kotsa K....Weetman A.P. (1997)
    1000. Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function. (PubMed id 8683128)9 Kariv I....Sweet R.W. (1996)
    1001. CTLA-4 ligation blocks CD28-dependent T cell activation. (PubMed id 8676075)9 Walunas T.L....Bluestone J.A. (1996)
    1002. CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis. (PubMed id 8759711)9 Perrin P.J....Racke M.K. (1996)
    1003. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. (PubMed id 8676074)9 Krummel M.F. and Allison J.P. (1996)
    1004. Cell-cell interactions regulate dendritic cell-dependent HIV-1 production in CD4+ T lymphocytes. (PubMed id 8526118)9 Pinchuk L.M....Clark E.A. (1995)
    1005. Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors. (PubMed id 7534620)9 Linsley P.S....Peach R. (1994)
    1006. Expression of functional B7 and CTLA4 on rheumatoid synovial T cells. (PubMed id 7517975)9 Verwilghen J....Pope R.M. (1994)
    1007. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. (PubMed id 7694363)9 Freeman G.J.... Nadler L.M. (1993)
    1008. A major costimulatory molecule on antigen-presenting cells, CTLA4 ligand A, is distinct from B7. (PubMed id 8228824)9 Wu Y....Liu Y. (1993)
    1009. Role of CD8+ CD25+ Foxp3+ regulatory T cells in multi ple sclerosis. (PubMed id 20437560)9 Correale J. and Villa A. (2010)
    1010. Belatacept in clinical and experimental transplantati on - progress and promise. (PubMed id 20502720)9 Rangel E.B. (2010)
    1011. Patients with oral squamous cell carcinoma are charac terized by increased frequency of suppressive regulatory T cells in the blood a nd tumor microenvironment. (PubMed id 20012605)9 Gasparoto T.H....Campanelli A.P. (2010)
    1012. Foxp3-transduced polyclonal regulatory T cells suppre ss NK cell functions in a TGF-beta dependent manner. (PubMed id 20166879)9 Zhou H....Zou P. (2010)
    1013. The biologic importance of tumor-infiltrating lymphoc ytes. (PubMed id 20482675)9 Hodi F.S. and Dranoff G. (2010)
    1014. Homeostasis of peripheral FoxP3(+) CD4 (+) regulatory T cells in patients with early and late stage breast cancer. (PubMed id 19855964)9 Rech A.J....Vonderheide R.H. (2010)
    1015. Regulatory function of cytomegalovirus-specific CD4+C D27-CD28- T cells. (PubMed id 20034645)9 Tovar-Salazar A....Weinberg A. (2010)
    1016. CTLA4 promoter polymorphisms are associated with cani ne diabetes mellitus. (PubMed id 20196832)9 Short A.D....Ollier W.E. (2010)
    1017. Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial. (PubMed id 20460488)9 Carthon B.C....Sharma P. (2010)
    1018. Novel immunotherapies as potential therapeutic partne rs for traditional or targeted agents: cytotoxic T-lymphocyte antigen-4 blockad e in advanced melanoma. (PubMed id 19952852)9 Agarwala S.S. (2010)
    1019. FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua. (PubMed id 20018909)9 MjAPsberg J....Ernerudh J. (2010)
    1020. Anti-CTLA-4 antibody therapy associated autoimmune hy pophysitis: serious immune related adverse events across a spectrum of cancer s ubtypes. (PubMed id 19639414)9 Dillard T....Fleseriu M. (2010)
    1021. Characterization of rabbit antithymocyte globulins-in duced CD25+ regulatory T cells from cells of patients with end-stage renal dise ase. (PubMed id 20164820)9 Sewgobind V.D....Baan C.C. (2010)
    1022. Isolation and characterization of human interleukin-1 0-secreting T cells from peripheral blood. (PubMed id 20034527)9 Mazza G....Wraith D.C. (2010)
    1023. The role of costimulatory molecules in allergic disea se and asthma. (PubMed id 19786798)9 Lombardi V....Akbari O. (2010)
    1024. Overcoming immunological tolerance to melanoma: Targe ting CTLA-4. (PubMed id 20482528)9 Hodi F.S. (2010)
    1025. Interaction of T-cell and antigen presenting cell co- stimulatory genes in childhood IgE. (PubMed id 19574333)9 Bottema R.W....Kerkhof M. (2010)
    1026. Genetics of thyroid autoimmunity and the role of the TSHR. (PubMed id 20083159)9 Brand O.J. and Gough S.C. (2010)
    1027. Regulatory T cells modulate Th17 responses in patient s with positive tuberculin skin test results. (PubMed id 19929695)9 Babu S....Nutman T.B. (2010)
    1028. Plasmodium vivax: induction of CD4+CD25+FoxP3+ regula tory T cells during infection are directly associated with level of circulating parasites. (PubMed id 20224778)9 Bueno L.L....Braga E.M. (2010)
    1029. Association between regulatory T cell activity and se psis and outcome of severely burned patients: a prospective, observational stud y. (PubMed id 20064232)9 Huang L.F....Sheng Z.Y. (2010)
    1030. Imaging of CTLA4 blockade-induced cell replication wi th (18)F-FLT PET in patients with advanced melanoma treated with tremelimumab. (PubMed id 20150263)9 Ribas A....Czernin J. (2010)
    1031. Ipilimumab monotherapy in patients with pretreated ad vanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. (PubMed id 20004617)9 Wolchok J.D....LebbAc C. (2010)
    1032. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodi es. (PubMed id 19581407)9 Peggs K.S....Allison J.P. (2009)
    1033. The regulatory function of umbilical cord blood CD4(+ ) CD25(+) T cells stimulated with anti-CD3/anti-CD28 and exogenous interleukin (IL)-2 or IL-15. (PubMed id 19302176)9 Lee C.C....Kuo M.L. (2009)
    1034. Regulatory T cells (Treg) in rheumatoid arthritis. (PubMed id 19028128)9 Boissier M.C....Bessis N. (2009)
    1035. FOXP3 and its role in the immune system. (PubMed id 20429413)9 Kim C.H. (2009)
    1036. Efficient induction and expansion of human alloantige n-specific CD8 regulatory T cells from naive precursors by CD40-activated B cel ls. (PubMed id 19684082)9 Zheng J....Tu W. (2009)
    1037. Therapeutic efficacy of ipilimumab, an anti-CTLA-4 mo noclonal antibody, in patients with metastatic melanoma unresponsive to prior s ystemic treatments: clinical and immunological evidence from three patient case s. (PubMed id 19139884)9 Di Giacomo A.M....Maio M. (2009)
    1038. Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors. (PubMed id 19028999)9 Jacobs J.F....Adema G.J. (2009)
    1039. PD-1 signaling in primary T cells. (PubMed id 19426218)9 Riley J.L. (2009)
    1040. [Regulatory T cells in children with acute lymphoblas tic leukaemia] (PubMed id 19648661)9 Stasiak-Barmuta A....SzymaA8ski M. (2009)
    1041. An integrated classification of pediatric inflammator y diseases, based on the concepts of autoinflammation and the immunological dis ease continuum. (PubMed id 19190531)9 McGonagle D....McDermott M.F. (2009)
    1042. Anti-CTLA-4 therapy-related autoimmune hypophysitis i n a melanoma patient. (PubMed id 19512947)9 Kaehler K.C....Hauschild A. (2009)
    1043. Impact of a recombinant fowlpox vaccine on the effica cy of adoptive cell therapy with tumor infiltrating lymphocytes in a patient wi th metastatic melanoma. (PubMed id 19752747)9 Smith F.O....Dudley M.E. (2009)
    1044. The genetics of autoimmune thyroid disease. (PubMed id 19343617)9 Weetman A.P. (2009)
    1045. Immune response genes in uveitis. (PubMed id 19657978)9 Du L....Yang P. (2009)
    1046. IL-17 secreted by tumor reactive T cells induces IL-8 release by human renal cancer cells. (PubMed id 19238009)9 Inozume T....Yang J.C. (2009)
    1047. Therapeutic breast cancer vaccines: a new strategy fo r early-stage disease. (PubMed id 19754218)9 Shumway N.M....Murray J.L. (2009)
    1048. The monoclonal antibody to cytotoxic T lymphocyte antigen 4, ipilimumab (MDX-010), a novel treatment strategy in cancer management. (PubMed id 19236253)9 Movva S. and Verschraegen C. (2009)
    1049. How do regulatory T cells work? (PubMed id 19751267)9 Corthay A. (2009)
    1050. Modulation of T-cell co-stimulation in rheumatoid art hritis: clinical experience with abatacept. (PubMed id 19243211)9 LaganA B....D'Amelio R. (2009)
    1051. [Genetics of autoimmune and collagen diseases] (PubMed id 19507500)9 Kochi Y. and Yamamoto K. (2009)
    1052. Association between CTLA-4 gene promoter (49 A/G) in exon 1 polymorphisms and inflammatory bowel disease in the Tunisian population. (PubMed id 19568552)9 Ben Alaya W....Ayed K. (2009)
    1053. Pharmacokinetics of CTLA4Ig fusion protein in healthy volunteers and patients with rheumatoid arthritis. (PubMed id 19262560)9 Ma Y....Guo Y.J. (2009)
    1054. [Pathogenesis of autoimmune thyroid diseases] (PubMed id 19347180)9 Sgarbi J.A. and Maciel R.M. (2009)
    1055. HSCT recipients have specific tolerance to MSC but no t to the MSC donor. (PubMed id 19561533)9 Sundin M....Blanc K.L. (2009)
    1056. An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodi es. (PubMed id 19416843)9 SchAPnfeld D....Skerra A. (2009)
    1057. Autoimmunity: CTLA-4: a key protein in autoimmunity. (PubMed id 19412189)9 Bayry J. (2009)
    1058. Suppression of glomerulonephritis in NZB/NZW lupus pr one mice by adoptive transfer of ex vivo expanded regulatory T cells. (PubMed id 19551149)9 Scalapino K.J. and Daikh D.I. (2009)
    1059. Production and characterization of transgenic pigs ex pressing porcine CTLA4-Ig. (PubMed id 20042047)9 Phelps C.J....Ayares D.L. (2009)
    1060. Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues. (PubMed id 19202079)9 Chen H....Sharma P. (2009)
    1061. What is the role of cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma? (PubMed id 19648604)9 Robert C. and Ghiringhelli F. (2009)
    1062. Serum cytotoxic T lymphocyte-associated antigen 4 in Hymenoptera venom allergy and its modulation by specific immunotherapy. (PubMed id 18926563)9 Saverino D....Pesce G. (2009)
    1063. The significantly enhanced frequency of functional CD4+CD25+Foxp3+ T regulatory cells in therapeutic dose aspirin-treated mice. (PubMed id 19146957)9 Javeed A....Zhao Y. (2009)
    1064. Potentiating endogenous antitumor immunity to prostate cancer through combination immunotherapy with CTLA4 blockade and GM-CSF. (PubMed id 19147575)9 Fong L....Small E.J. (2009)
    1065. Multiple functions of human T cells generated by expe rimental malaria challenge. (PubMed id 19658096)9 Todryk S.M....Hill A.V. (2009)
    1066. The prevalence of FOXP3+ regulatory T-cells in periph eral blood of patients with NSCLC. (PubMed id 19538059)9 Li L....Shi-ang H. (2009)
    1067. Autoimmunity risk alleles in costimulation pathways. (PubMed id 19426231)9 Maier L.M. and Hafler D.A. (2009)
    1068. Induction of IL-10- and IFN-gamma-producing T-cell re sponses by autoreactive T-cells expressing human T-cell leukemia virus type I T ax. (PubMed id 19654198)9 Takatsuka N....Kannagi M. (2009)
    1069. Selective costimulation modulation with abatacept: a look at quality-of-life outcomes in patients with rheumatoid arthritis. (PubMed id 18538830)9 Shergy W.J. (2009)
    1070. BiTE: Teaching antibodies to engage T-cells for cancer therapy. (PubMed id 19169956)9 Baeuerle P.A....Bargou R. (2009)
    1071. CD13+CD4+CD25hi regulatory T cells exhibit higher sup pressive function and increase with tumor stage in non-small cell lung cancer p atients. (PubMed id 19597336)9 Ju S....Shu Y. (2009)
    1072. Expanding and converting regulatory T cells: a horizo n for immunotherapy. (PubMed id 19479206)9 Khattar M....Stepkowski S.M. (2009)
    1073. Protein disulfide isomerases are antibody targets during immune-mediated tumor destruction. (PubMed id 19008459)9 Fonseca C....Dranoff G. (2009)
    1074. Beyond tumor necrosis factor: next-generation biologi c therapy for inflammatory bowel disease. (PubMed id 19786766)9 Podolsky D.K. (2009)
    1075. Pathogenesis of primary adrenal insufficiency. (PubMed id 19500759)9 Husebye E....vAYs K. (2009)
    1076. Immune modulation in melanoma and advanced cancer the rapy: anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibodies. (PubMed id 19793711)9 Esper P. (2009)
    1077. Filarial lymphedema is characterized by antigen-specific Th1 and th17 proinflammatory responses and a lack of regulatory T cells. (PubMed id 19381284)9 Babu S....Nutman T.B. (2009)
    1078. Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications. (PubMed id 19349365)9 AndrAc S....Bayry J. (2009)
    1079. Functional activation of proline-rich tyrosine kinase 2 (PYK2) in peripheral blood mononuclear cells from patients with systemic lupu s erythematosus. (PubMed id 19919693)9 Wang M....Zhang Y. (2009)
    1080. The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's dise ase. (PubMed id 19961590)9 Penna-Martinez M....Badenhoop K. (2009)
    1081. Immunotherapy of distant metastatic disease. (PubMed id 19617297)9 Schadendorf D....Hersey P. (2009)
    1082. The onset of diabetes in three out of four sisters: a Japanese family with type 1 diabetes. A case report. (PubMed id 19506323)9 Kishi A....Maegawa H. (2009)
    1083. The etiology of autoimmune thyroid disease: a story of genes and environment. (PubMed id 19307103)9 Tomer Y. and Huber A. (2009)
    1084. CTLA-4Ig: uses and future directions. (PubMed id 19519590)9 Ben-Shoshan M. (2009)
    1085. Docosahexaenoic acid reduces suppressive and migrator y functions of CD4+CD25+ regulatory T-cells. (PubMed id 19561360)9 Yessoufou A....Khan N.A. (2009)
    1086. CD4+ CD25+ Foxp3- T-regulatory cells produce both gam ma interferon and interleukin-10 during acute severe murine spotted fever ricke ttsiosis. (PubMed id 19564386)9 Fang R....Walker D.H. (2009)
    1087. Cytotoxic T-lymphocyte-associated antigen 4 antibody- induced colitis and its management with infliximab. (PubMed id 19104936)9 Johnston R.L....Barkin J.S. (2009)
    1088. T cell receptor signaling co-regulates multiple Golgi genes to enhance N-glycan branching. (PubMed id 19706602)9 Chen H.L....Demetriou M. (2009)
    1089. Unraveling the genetics of complex diseases: suscepti bility genes for rheumatoid arthritis and psoriasis. (PubMed id 19446472)9 Li Y. and Begovich A.B. (2009)
    1090. The relationship between thyroid function, serum monokine induced by interferon gamma and soluble interleukin-2 receptor in thyroid autoimmune diseases. (PubMed id 19250272)9 Jiskra J....LacinovA! Z. (2009)
    1091. Regulatory cells, cytokine pattern and clinical risk factors for asthma in infants and young children with recurrent wheeze. (PubMed id 19438590)9 Borrego L.M....Trindade H. (2009)
    1092. Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory t cells in the granulomatous lesions. (PubMed id 19435796)9 Rahman S....Brighenti S.G. (2009)
    1093. Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections. (PubMed id 19426215)9 Pentcheva-Hoang T....Allison J.P. (2009)
    1094. Allogeneic induced human FOXP3(+)IFN-gamma(+) T cells exhibit selective suppressive capacity. (PubMed id 19634189)9 Stroopinsky D....Katz T. (2009)
    1095. Novel mechanisms of suppressor activity exhibited by cytotoxic regulatory T cell lines, HOZOT. (PubMed id 19013006)9 Suzuki M....Kibata M. (2009)
    1096. Epidemiology and gene markers of ulcerative colitis in the Chinese. (PubMed id 19230040)9 Yun J....Pan B.R. (2009)
    1097. Clinical grade production of IL-10 producing regulato ry Tr1 lymphocytes for cell therapy of chronic inflammatory diseases. (PubMed id 19539556)9 Brun V....Foussat A. (2009)
    1098. Expression of regulatory T-cell-related molecule genes and clinical outcome in kidney transplant recipients. (PubMed id 19300189)9 Alvarez C.M....SA1sal C. (2009)
    1099. [Biological agents] (PubMed id 19280938)9 Amano K. (2009)
    1100. [Genetics of thyroid autoimmunity - update and clinical relevance] (PubMed id 19337711)9 Dultz G....Kahaly G.J. (2009)
    1101. Ipilimumab: controversies in its development, utility and autoimmune adverse events. (PubMed id 19198837)9 Weber J. (2009)
    1102. [Efficacy of new biologics on bone destruction in rheumatoid arthritis] (PubMed id 19252247)9 Kazuyoshi S. and Tanaka Y. (2009)
    1103. Abatacept does not induce direct gene expression chan ges in antigen-presenting cells. (PubMed id 19259798)9 Carman J.A....Nadler S.G. (2009)
    1104. Foxp3 processing by proprotein convertases and control of regulatory T cell function. (PubMed id 19117830)9 de Zoeten E.F....Ozkaynak E. (2009)
    1105. Analysis of 19 genes for association with type I diab etes in the Type I Diabetes Genetics Consortium families. (PubMed id 19956106)9 Howson J.M....Todd J.A. (2009)
    1106. T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy. (PubMed id 18941113)9 Houot R. and Levy R. (2009)
    1107. Costimulatory pathways in multiple sclerosis: distinc tive expression of PD-1 and PD-L1 in patients with different patterns of disease. (PubMed id 19794071)9 Trabattoni D....Clerici M. (2009)
    1108. Dasatinib inhibits the proliferation and function of CD4+CD25+ regulatory T cells. (PubMed id 19016717)9 Fei F....Schmitt M. (2009)
    1109. Genetics of graves' disease: the lost concept. (PubMed id 19258680)9 Sibarani R.P. (2009)
    1110. Ex vivo expanded human CD4+CD25+Foxp3+ regulatory T cells prevent lethal xenogenic graft versus host disease (GVHD). (PubMed id 19410243)9 Cao T....Li L. (2009)
    1111. Genetic factors affecting the occurrence, clinical phenotype, and outcome of autoimmune hepatitis. (PubMed id 18328791)9 Czaja A.J. (2008)
    1112. Fusions of dendritic cells with breast carcinoma stimulate the expansion of regulatory T cells while concomitant exposure to IL-12, CpG oligodeoxynucleotides, and anti-CD3/CD28 promotes the expansion of activated tumor reactive cells. (PubMed id 18566447)9 Vasir B....Avigan D. (2008)
    1113. Concurrent decrease in IL-10 with development of immune-related adverse events in a patient treated with anti-CTLA-4 therapy. (PubMed id 18503261)9 Sun J....Sharma P. (2008)
    1114. Overcoming immunologic tolerance to melanoma: targeting CTLA-4 with tremelimumab (CP-675,206). (PubMed id 19001146)9 Ribas A. (2008)
    1115. Association of genetic polymorphisms and autoimmune A ddison's disease. (PubMed id 20477573)9 Falorni A....Gambelunghe G. (2008)
    1116. Genetic Basis of Type 1 Diabetes: Similarities and Differences between East and West. (PubMed id 18795209)9 Ikegami H....Kawabata Y. (2008)
    1117. Activation of counter-regulatory mechanisms in a rat renal acute rejection model. (PubMed id 18261221)9 Edemir B....Schlatter E. (2008)
    1118. Interaction of human PD-L1 and B7-1. (PubMed id 18585785)9 Butte M.J....Sharpe A.H. (2008)
    1119. Co-stimulatory modulation in rheumatoid arthritis: th e role of (CTLA4-Ig) abatacept. (PubMed id 18718877)9 Fiocco U....Punzi L. (2008)
    1120. Circulating CD4+ CD25+ regulatory T cells correlate with chronic hepatitis B infection. (PubMed id 17764450)9 Peng G....Chen Z. (2008)
    1121. Cell-penetrating peptides and proteins: new inhibitors of allergic airways disease. (PubMed id 18418441)9 Kinyanjui M.W. and Fixman E.D. (2008)
    1122. The characterization and role of regulatory T cells in immune reactions. (PubMed id 17981708)9 Wilczynski J.R....Kalinka J. (2008)
    1123. CCR5-dependent regulatory T cell migration mediates fungal survival and severe immunosuppression. (PubMed id 18292527)9 Moreira A.P....Silva J.S. (2008)
    1124. Targeting metastatic melanoma. (PubMed id 19052265)9 Poust J. (2008)
    1125. alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice. (PubMed id 18852465)9 Lewis E.C....Dinarello C.A. (2008)
    1126. Common Cellular and Diverse Genetic Basis of Thymoma-associated Myasthenia Gravis: Role of MHC Class II and AIRE Genes and Genetic Polymorphisms. (PubMed id 18567864)9 Strobel P....Marx A. (2008)
    1127. Targeting of interleukin-10 is superior to cytotoxic T-lymphocyte associated antigen 4 with human immunoglobulin G(1) for the prevention of chronic allograft deterioration in organ transplantation. (PubMed id 18816483)9 Xu T....Tsui T.Y. (2008)
    1128. Ctla-4 blockade confers lymphocyte resistance to regulatory T-cells in advanced melanoma: surrogate marker of efficacy of tremelimumab? (PubMed id 18698043)9 MAcnard C....Robert C. (2008)
    1129. Expansion of circulating Foxp3+)D25bright CD4+ T cells during specific venom immunotherapy. (PubMed id 18070166)9 Pereira-Santos M.C....Sousa A.E. (2008)
    1130. IL-27 inhibits the development of regulatory T cells via STAT3. (PubMed id 18156621)9 Huber M....Lohoff M. (2008)
    1131. [Molecular genetics of type 1 diabetes mellitus: achievements and future trends] (PubMed id 18988535)9 Nosikov V.V. and Seregin I.u.A. (2008)
    1132. Treatment with type I interferons induces a regulatory T cell subset in peripheral blood mononuclear cells from multiple sclerosis patients. (PubMed id 18442793)9 PentA^n-Rol G....LA^pez-Saura P. (2008)
    1133. CTLA-4: negative regulator of the immune response and a target for cancer therapy. (PubMed id 18463542)9 Keilholz U. (2008)
    1134. Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis. (PubMed id 18451325)9 Cardoso C.R....Silva J.S. (2008)
    1135. Effects of inhaled fluticasone propionate on CTLA-4-positive CD4+CD25+ cells in induced sputum in mild asthmatics. (PubMed id 18699801)9 Kawayama T....Aizawa H. (2008)
    1136. Gene-gene interactions in the NOD mouse model of type 1 diabetes. (PubMed id 19111166)9 Ridgway W.M....Wicker L.S. (2008)
    1137. Effect of low-dose IL-2 immunotherapy on frequency and phenotype of regulatory T cells and NK cells in HIV/HCV-coinfected patients. (PubMed id 18275348)9 Velilla P.A....Chougnet C. (2008)
    1138. Recent insights into the pathogenesis and management of thyroid-associated ophthalmopathy. (PubMed id 18769218)9 Gianoukakis A.G. and Smith T.J. (2008)
    1139. The reverse stop-signal model for CTLA4 function. (PubMed id 18219311)9 Rudd C.E. (2008)
    1140. Genetic background of IL-10(-/-) mice alters host-pathogen interactions with Campylobacter jejuni and influences disease phenotype. (PubMed id 18586081)9 Mansfield L.S....Bell J.A. (2008)
    1141. ret/PTC-1 expression alters the immunoprofile of thyroid follicular cells. (PubMed id 18505566)9 Denning K....Sheils O. (2008)
    1142. The mechanism of anti-CTLA-4 activity and the negative regulation of T-cell activation. (PubMed id 19001145)9 Wolchok J.D. and Saenger Y. (2008)
    1143. CTLA-4 directly inhibits osteoclast formation. (PubMed id 18203760)9 Axmann R....Schett G. (2008)
    1144. Regulatory T-cell expansion and function do not account for the impaired alloreactivity of ex vivo-expanded T cells. (PubMed id 18445006)9 Montcuquet N....Robinet E. (2008)
    1145. Enhancement of immunotherapeutic effects of HPV16E7 on cervical cancer by fusion with CTLA4 extracellular region. (PubMed id 19107404)9 Zheng Y....Huang L. (2008)
    1146. Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. (PubMed id 18287062)9 Hodi F.S....Dranoff G. (2008)
    1147. In vitro induction of regulatory T cells by anti-CD3 antibody in humans. (PubMed id 18191540)9 Abraham M....Weiner H.L. (2008)
    1148. Molecular mechanisms of autoimmunity. (PubMed id 18324481)9 Atassi M.Z. and Casali P. (2008)
    1149. Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis. (PubMed id 19066215)9 Choi J.M....Lee S.K. (2008)
    1150. Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis. (PubMed id 18250419)9 Aricha R....Souroujon M.C. (2008)
    1151. Novel therapies targeting the immune system: CTLA4 blockade with tremelimumab (CP-675,206), a fully human monoclonal antibody. (PubMed id 18321236)9 Camacho L.H. (2008)
    1152. CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit. (PubMed id 19074257)9 Yuan J....Wolchok J.D. (2008)
    1153. [Main regulatory factors for differentiation, development and function of naturally occurred CD4+ CD25+ regulatory T cells] (PubMed id 18315933)9 Wu M. and Xue Y.H. (2008)
    1154. Novel homozygous AIRE mutation in a German patient with severe APECED. (PubMed id 19209622)9 von Schnurbein J....Wabitsch M. (2008)
    1155. Fetal tolerance in human pregnancy--a crucial balance between acceptance and limitation of trophoblast invasion. (PubMed id 18055021)9 von Rango U. (2008)
    1156. The HLA gene complex in thyroid autoimmunity: from epidemiology to etiology. (PubMed id 18178059)9 Jacobson E.M....Tomer Y. (2008)
    1157. Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. (PubMed id 18519750)9 Sfanos K.S....Drake C.G. (2008)
    1158. The CD4+CD26- T-cell population in classical Hodgkin's lymphoma displays a distinctive regulatory T-cell profile. (PubMed id 18362907)9 Ma Y....van den Berg A. (2008)
    1159. Anti-cytotoxic T-lymphocyte antigen-4 antibody: the first in an emerging class of immunomodulatory antibodies for cancer treatment. (PubMed id 18838703)9 Fong L. and Small E.J. (2008)
    1160. Colorectal Cancer Treatment: What's Next? (or: Is The re Life After EGFR and VEGF?). (PubMed id 19343143)9 Saltz L. (2008)
    1161. Genetics and natural history of multiple sclerosis. (PubMed id 18256983)9 Kantarci O.H. (2008)
    1162. Overcoming immunologic tolerance to melanoma: targeting CTLA-4 with ipilimumab (MDX-010). (PubMed id 19001147)9 Weber J. (2008)
    1163. Tremelimumab (CP-675,206): a fully human anticytotoxic T lymphocyte-associated antigen 4 monoclonal antibody for treatment of patients with advanced cancers. (PubMed id 18774925)9 Tarhini A.A. and Kirkwood J.M. (2008)
    1164. Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections. (PubMed id 18613845)9 Ha S.J....Ahmed R. (2008)
    1165. Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. (PubMed id 18776148)9 Huber A....Tomer Y. (2008)
    1166. CTLA-4 blockade with monoclonal antibodies in patients with metastatic cancer: surgical issues. (PubMed id 18716842)9 Phan G.Q....Sondak V.K. (2008)
    1167. Parallel expansion of human virus-specific FoxP3- effector memory and de novo-generated FoxP3+ regulatory CD8+ T cells upon antigen recognition in vitro. (PubMed id 17617596)9 Billerbeck E....Thimme R. (2007)
    1168. Celiac disease and autoimmune thyroid disease. (PubMed id 18056028)9 Ch'ng C.L....Kingham J.G. (2007)
    1169. A pilot trial of CTLA-4 blockade with human anti-CTLA-4 in patients with hormone-refractory prostate cancer. (PubMed id 17363537)9 Small E.J....Allison J.P. (2007)
    1170. Functional evaluation of the type 1 diabetes (T1D) susceptibility candidate genes. (PubMed id 17448564)9 Park Y. (2007)
    1171. Helicobacter pylori inflammation, immunity, and vaccines. (PubMed id 17727455)9 D'Elios M.M. and Andersen L.P. (2007)
    1172. Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses. (PubMed id 17575163)9 Tuve S....Lieber A. (2007)
    1173. Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction. (PubMed id 17606437)9 Prevosto C....Poggi A. (2007)
    1174. In vitro expansion of CD4+CD25highFOXP3+CD127low/- regulatory T cells from peripheral blood lymphocytes of healthy Mycobacterium tuberculosis-infected humans. (PubMed id 17890131)9 Hougardy J.M....Mascart F. (2007)
    1175. The genetic basis of thyroid autoimmunity. (PubMed id 17824829)9 Jacobson E.M. and Tomer Y. (2007)
    1176. Abatacept binds to the Fc receptor CD64 but does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytoto xicity. (PubMed id 17787038)9 Davis P.M....Suchard S.J. (2007)
    1177. Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells. (PubMed id 17164341)9 Curti A....Lemoli R.M. (2007)
    1178. Enhancement of lymphokine-activated killer cell induction using anti-CD25 and anti-CTLA-4 monoclonal antibodies. (PubMed id 17487401)9 Okita R....Toge T. (2007)
    1179. Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin. (PubMed id 17182569)9 Strauss L....Zippelius A. (2007)
    1180. Update on anti-CTLA-4 antibodies in clinical trials. (PubMed id 17696822)9 Langer L.F....Morse M.A. (2007)
    1181. The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: back to the future. (PubMed id 17369021)9 Jacobson E.M. and Tomer Y. (2007)
    1182. Surveillance of the eye and vision in clinical trials of CP-675,206 for metastatic melanoma. (PubMed id 17434437)9 Straatsma B.R....Ribas A. (2007)
    1183. Role and mechanisms of CD4+CD25+ regulatory T cells in the induction and maintenance of transplantation tolerance. (PubMed id 17306743)9 Yong Z....Yi L. (2007)
    1184. Current status of lupus genetics. (PubMed id 17509159)9 Sestak A.L....Harley J.B. (2007)
    1185. Hepatocellular carcinoma cell supernatants increase expansion and function of CD4(+)CD25(+) regulatory T cells. (PubMed id 17372588)9 Cao M....Nelson D.R. (2007)
    1186. The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck. (PubMed id 17975141)9 Strauss L....Whiteside T.L. (2007)
    1187. Soluble CTLA-4 in autoimmune thyroid diseases: relationship with clinical status and possible role in the immune response dysregulation. (PubMed id 17321799)9 Saverino D....Bagnasco M. (2007)
    1188. Trypanosoma cruzi infection induces differential modulation of costimulatory molecules and cytokines by monocytes and T cells from patients with indeterminate and cardiac Chagas' disease. (PubMed id 17283096)9 Souza P.E....Dutra W.O. (2007)
    1189. IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. (PubMed id 16968902)9 Clark R.A. and Kupper T.S. (2007)
    1190. Intragraft FOXP3 mRNA expression reflects antidonor immune reactivity in cardiac allograft patients. (PubMed id 17565321)9 Dijke I.E....Baan C.C. (2007)
    1191. Soluble costimulatory factors sCD28, sCD80, sCD86 and sCD152 in relation to other markers of immune activation in patients with myasthenia gravis. (PubMed id 17346804)9 Kakoulidou M....Lefvert A.K. (2007)
    1192. [Management for TNF failure] (PubMed id 17642247)9 Mukai M. (2007)
    1193. Functional and phenotypic characteristics of CD4+CD25highFoxp3+ Treg clones obtained from peripheral blood of patients with cancer. (PubMed id 17691114)9 Strauss L....Whiteside T.L. (2007)
    1194. Immunogenetic factors determining the evolution of T-cell large granular lymphocyte leukaemia and associated cytopenias. (PubMed id 17156396)9 Nearman Z.P....Maciejewski J.P. (2007)
    1195. The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cells. (PubMed id 16902146)9 Kreijveld E....Joosten I. (2007)
    1196. Treatment of patients with advanced soft tissue sarcoma: disappointment or challenge? (PubMed id 17545796)9 Kasper B....Awada A. (2007)
    1197. Genetics of type 1 diabetes in Asian and Caucasian populations. (PubMed id 17452059)9 Ikegami H....Ogihara T. (2007)
    1198. Diagnosis of acute renal allograft rejection by analyzing whole blood mRNA expression of lymphocyte marker molecules. (PubMed id 17414714)9 Alakulppi N.S....Laine J.T. (2007)
    1199. Hodgkin's reed-sternberg cell line (KM-H2) promotes a bidirectional differentiation of CD4+CD25+Foxp3+ T cells and CD4+ cytotoxic T lymphocytes from CD4+ naive T cells. (PubMed id 17545218)9 Tanijiri T....Fukuhara S. (2007)
    1200. Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine. (PubMed id 17588483)9 Shaffer J....Sykes M. (2007)
    1201. The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro. (PubMed id 17545278)9 Yates J....Garden O.A. (2007)
    1202. [CTLA4-Ig (abatacept)] (PubMed id 17642237)9 Harigai M. (2007)
    1203. Frequencies and role of regulatory T cells in patients with (pre)malignant cervical neoplasia. (PubMed id 17937675)9 Visser J....Daemen T. (2007)
    1204. The role of the CTLA4 blockade in the treatment of malignant melanoma. (PubMed id 18027152)9 Cranmer L.D. and Hersh E. (2007)
    1205. Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection. (PubMed id 17229698)9 Larrea E....Prieto J. (2007)
    1206. [Effect of CTLA4-Ig on radiographic outcome of patien ts with rheumatoid arthritis] (PubMed id 17404488)9 Harigai M. (2007)
    1207. Regulatory T-cell markers, indoleamine 2,3-dioxygenase, and virus levels in spleen and gut during progressive simian immunodeficiency virus infection. (PubMed id 17715231)9 Boasso A....Chougnet C. (2007)
    1208. Cytotoxic T-lymphocyte-associated antigen-4. (PubMed id 17875750)9 Hodi F.S. (2007)
    1209. Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. (PubMed id 17982122)9 Downey S.G....Rosenberg S.A. (2007)
    1210. The role of indoleamine 2,3-dioxygenase in transplantation. (PubMed id 17239019)9 Hainz U....Heitger A. (2007)
    1211. Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function. (PubMed id 17621372)9 Pillemer B.B....Ray A. (2007)
    1212. Extremely high frequency of autoimmune-predisposing alleles in medieval specimens. (PubMed id 17610332)9 Witas H.W....Zawicki P. (2007)
    1213. ICER/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cells. (PubMed id 17372992)9 Bodor J....Sakaguchi S. (2007)
    1214. IL-2-independent generation of FOXP3(+)CD4(+)CD8(+)CD25(+) cytotoxic regulatory T cell lines from human umbilical cord blood. (PubMed id 17258077)9 Nakamura S....Kibata M. (2007)
    1215. Enhanced efficacy of CTLA-4 fusion anti-caries DNA vaccines in gnotobiotic hamsters. (PubMed id 17640488)9 Zhang F....Tian Q.W. (2007)
    1216. Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction. (PubMed id 17906628)9 Kaufmann D.E....Walker B.D. (2007)
    1217. Human resting CD4+ T cells are constitutively inhibited by TGF beta under steady-state conditions. (PubMed id 17513742)9 Classen S....Schultze J.L. (2007)
    1218. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. (PubMed id 17377532)9 Ono M....Sakaguchi S. (2007)
    1219. Protective autoimmunity in cancer (review). (PubMed id 17143505)9 Toubi E. and Shoenfeld Y. (2007)
    1220. CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo. (PubMed id 17878360)9 Taylor M.D....Maizels R.M. (2007)
    1221. Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): a novel strategy for the treatment of melanoma and other malignancies. (PubMed id 18000991)9 O'Day S.J....Urba W.J. (2007)
    1222. Analysis of candidate susceptibility genes in canine diabetes. (PubMed id 17611256)9 Short A.D....Ollier W.E. (2007)
    1223. Immune accessory functions of human endothelial cells are modulated by overexpression of B7-H1 (PDL1). (PubMed id 16916652)9 LaGier A.J. and Pober J.S. (2006)
    1224. B7+ iris pigment epithelium induce CD8+ T regulatory cells; both suppress CTLA-4+ T cells. (PubMed id 16365402)9 Sugita S....Streilein J.W. (2006)
    1225. Human CD4+CD25high regulatory T cells modulate myeloid but not plasmacytoid dendritic cells activation. (PubMed id 16621995)9 Houot R....Lebecque S. (2006)
    1226. Combinatorial cancer immunotherapy. (PubMed id 16730268)9 Hodi F.S. and Dranoff G. (2006)
    1227. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. (PubMed id 16903919)9 Izcue A....Powrie F. (2006)
    1228. Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases. (PubMed id 17041104)9 Lee C.H....Hwang S.T. (2006)
    1229. The clinical utility of cytotoxic T lymphocyte antigen 4 abrogation by human antibodies. (PubMed id 17013086)9 Weber J.S. (2006)
    1230. Mechanisms of allergen-specific immunotherapy: T-regulatory cells and more. (PubMed id 16701141)9 Verhagen J....Akdis M. (2006)
    1231. Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma. (PubMed id 16403912)9 Yang Z.Z....Ansell S.M. (2006)
    1232. [Expression pattern and level of cytotoxic T lymphocyte-associated antigen-4 targeted anti-caries plasmids in eukaryotic cells] (PubMed id 16784605)9 Guo J.H....Yu F. (2006)
    1233. Higher prevalence of autoantibodies to insulin and GAD65 in Swedish compared to Lithuanian children with type 1 diabetes. (PubMed id 16442659)9 Holmberg H....Ludvigsson J. (2006)
    1234. Inhibition of the transcription factor Foxp3 converts desmoglein 3-specific type 1 regulatory T cells into Th2-like cells. (PubMed id 16493082)9 Veldman C....Hertl M. (2006)
    1235. Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma. (PubMed id 16799341)9 Maker A.V....Rosenberg S.A. (2006)
    1236. Basic science for the clinician 37: Protecting against autoimmunity-tolerance: mechanisms of negative selection in the thymus. (PubMed id 16601548)9 Sigal L.H. (2006)
    1237. Non-HLA associations with autoimmune diseases. (PubMed id 16483921)9 Serrano N.C....PA!ez M.C. (2006)
    1238. Regulatory networks induced by live parasites impair both Th1 and Th2 pathways in patent lymphatic filariasis: implications for parasite persistence. (PubMed id 16493086)9 Babu S....Nutman T.B. (2006)
    1239. CD127+CCR5+CD38+++ CD4+ Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2+ memory CD4+ T cells. (PubMed id 17005692)9 Zaunders J.J....Kelleher A.D. (2006)
    1240. Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study. (PubMed id 17052659)9 Barcellos L.F....Hauser S.L. (2006)
    1241. Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases. (PubMed id 16519819)9 Smyth D.J....Todd J.A. (2006)
    1242. Update on immunotherapy for melanoma. (PubMed id 16884670)9 Ribas A. (2006)
    1243. Retraction: Studies on the genetic pathogenesis of myasthenia gravis caused by CTLA-4 gene polymorphism. (PubMed id 16456801)9 Mao H.T....Gu H.T. (2006)
    1244. [Regulatory T cells] (PubMed id 17217101)9 Marinic I....Rabatic S. (2006)
    1245. Inhibition of human allergic T-helper type 2 immune responses by induced regulatory T cells requires the combination of interleukin-10-treated dendritic cells and transforming growth factor-beta for their induction. (PubMed id 17177678)9 Bellinghausen I....Saloga J. (2006)
    1246. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells. (PubMed id 16556256)9 Taylor A....Akdis C.A. (2006)
    1247. [CD28 and CTLA-4 costimulatory molecules expression on T lymphocytes and NK cells in nonallergic bronchial asthma] (PubMed id 16708626)9 Rutkowski R....Sidorczuk M. (2006)
    1248. Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity. (PubMed id 16849577)9 Kocak E....Liu Y. (2006)
    1249. CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques. (PubMed id 16896154)9 Hryniewicz A....Franchini G. (2006)
    1250. [The phenotype and function of CD4+ CD25+ regulatory T cells in hepatitis B patients] (PubMed id 17074148)9 Fu J.L....Wang F.S. (2006)
    1251. Delineation of immunoregulatory properties of adult T-cell leukemia cells. (PubMed id 16867905)9 Matsubar Y....Uchiyama T. (2006)
    1252. CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. (PubMed id 16586370)9 Campanelli A.P....Silva J.S. (2006)
    1253. Characteristics of rat CD4(+)CD25(+) T cells and their ability to prevent not only diabetes but also insulitis in an adoptive transfer model in BB rats. (PubMed id 16784487)9 Holm T.L....Markholst H. (2006)
    1254. Clinical review: Type 1 diabetes-associated autoimmunity: natural history, genetic associations, and screening. (PubMed id 16403820)9 Barker J.M. (2006)
    1255. Immunopathological and genetic features in slowly progressive insulin-dependent diabetes mellitus and latent autoimmune diabetes in adults. (PubMed id 17130533)9 Kobayashi T....Maruyama T. (2006)
    1256. Regulatory T cells in immune surveillance and treatment of cancer. (PubMed id 16376102)9 Yamaguchi T. and Sakaguchi S. (2006)
    1257. HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS. (PubMed id 16902147)9 Nilsson J....Chougnet C. (2006)
    1258. CTLA-4.FasL inhibits allogeneic responses in vivo. (PubMed id 16828466)9 Dranitzki-Elhalel M....Tykocinski M.L. (2006)
    1259. Treatment of rheumatoid arthritis with rituximab: an update and possible indications. (PubMed id 16920570)9 De Vita S. and Quartuccio L. (2006)
    1260. Maturational alterations of peripheral T cell subsets and cytokine gene expression in 22q11.2 deletion syndrome. (PubMed id 16542369)9 Kanaya Y....Hara T. (2006)
    1261. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. (PubMed id 16710025)9 Beck K.E....Yang J.C. (2006)
    1262. Mechanism of T cell hyporesponsiveness to HBcAg is associated with regulatory T cells in chronic hepatitis B. (PubMed id 16865771)9 Kondo Y....Shimosegawa T. (2006)
    1263. CD25 regulatory T cells determine secondary but not primary remission in EAE: impact on long-term disease progression. (PubMed id 16360886)9 GAortner D....Brunner-Weinzierl M.C. (2006)
    1264. Coinhibitory T-cell signaling in islet allograft rejection and tolerance. (PubMed id 16719045)9 Truong W....Shapiro A.M. (2006)
    1265. Reduced function of CD4+25+ regulatory T cell fraction in silicosis patients. (PubMed id 16831302)9 Wu P....Otsuki T. (2006)
    1266. From bases to basis: linking genetics to causation in primary biliary cirrhosis. (PubMed id 15880308)9 Invernizzi P....Gershwin M.E. (2005)
    1267. Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. (PubMed id 16224277)9 Blansfield J.A....Sherry R.M. (2005)
    1268. Type 1 diabetes genes and pathways shared by humans and NOD mice. (PubMed id 16257508)9 Wicker L.S....Peterson L.B. (2005)
    1269. Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. (PubMed id 15814720)9 Taylor M.D....Maizels R.M. (2005)
    1270. Genetic susceptibility in thyroid autoimmunity. (PubMed id 16369210)9 Ban Y. and Tomer Y. (2005)
    1271. Increased expression of CD152 (CTLA-4) by normal T lymphocytes in untreated patients with B-cell chronic lymphocytic leukemia. (PubMed id 16094420)9 Motta M....Wierda W.G. (2005)
    1272. HIV may produce inhibitory microRNAs (miRNAs) that bl ock production of CD28, CD4 and some interleukins. (PubMed id 15862587)9 Couturier J.P. and Root-Bernstein R.S. (2005)
    1273. Coculture of Th cells with interleukin (IL)-7 in the absence of antigenic stimuli induced T-cell anergy reversed by IL-15. (PubMed id 15993713)9 Chen Y.Z....Nishimura Y. (2005)
    1274. Estrogen and brain inflammation: effects on microglial expression of MHC, costimulatory molecules and cytokines. (PubMed id 15748951)9 Dimayuga F.O....Bruce-Keller A.J. (2005)
    1275. Pre-eclampsia is not associated with changes in the levels of regulatory T cells in peripheral blood. (PubMed id 16305664)9 Paeschke S....Zenclussen A.C. (2005)
    1276. Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies. (PubMed id 16037385)9 Lute K.D....Liu Y. (2005)
    1277. Novel agents in development for the treatment of mela noma. (PubMed id 16022577)9 Tarhini A.A. and Agarwala S.S. (2005)
    1278. Technology evaluation: ipilimumab, Medarex/Bristol-Myers Squibb. (PubMed id 16370382)9 Morse M.A. (2005)
    1279. Evaluation of CD86 gene polymorphism at +1057 position in liver transplant recipients. (PubMed id 16223675)9 Marin L.A....Alvarez-Lopez M.R. (2005)
    1280. The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients. (PubMed id 15749840)9 Andersson J....Chougnet C.A. (2005)
    1281. Regulatory polymorphisms underlying complex disease traits. (PubMed id 15592805)9 Knight J.C. (2005)
    1282. Sex-specific association of PTPN22 1858T with type 1 diabetes but not with Hashimoto's thyroiditis or Addison's disease in the German population. (PubMed id 16322396)9 Kahles H....Badenhoop K. (2005)
    1283. Disruption of T cell regulatory pathways is necessary for immunotherapeutic cure of T cell acute lymphoblastic leukemia in mice. (PubMed id 16464745)9 Fiorentino S....Regnault A. (2005)
    1284. Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells. (PubMed id 15466932)9 Boasso A....Shearer G.M. (2005)
    1285. Tumor regression and autoimmunity in cytotoxic T lymphocyte-associated antigen 4 blockade-treated patients. (PubMed id 16244797)9 Weber J.S. (2005)
    1286. Targeted delivery of the ErbB2/HER2 tumor antigen to professional APCs results in effective antitumor immunity. (PubMed id 15843546)9 Rohrbach F....Wels W.S. (2005)
    1287. Assessment of selected co-stimulatory, adhesion and activatory molecules and cytokines of Th(1)/Th(2) balance in acute lymphoblastic leukemia in children. (PubMed id 16088321)9 LuczyA8ski W....Malinowska I. (2005)
    1288. Autoimmunity in a phase I trial of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and Montanide ISA 51 for patients with resected stages III and IV melanoma. (PubMed id 15613700)9 Sanderson K....Weber J. (2005)
    1289. Regulatory T-cells infiltrate periodontal disease tissues. (PubMed id 15972593)9 Nakajima T....Yamazaki K. (2005)
    1290. Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells. (PubMed id 15514008)9 Berger C.L....Edelson R.L. (2005)
    1291. In vivo infusion of interleukin-1beta and chorionic gonadotropin induces endometrial changes that mimic early pregnancy events in the baboon. (PubMed id 15932926)9 Strakova Z....Fazleabas A.T. (2005)
    1292. Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function. (PubMed id 16180249)9 Jarvis L.B....Gaston J.S. (2005)
    1293. Susceptibility genes in thyroid autoimmunity. (PubMed id 15712599)9 Ban Y. and Tomer Y. (2005)
    1294. [Study on the cytotoxic T-lymphocyte related antigen 4 exons 1A/G49 polymorphism in patients of insulin-dependent diabetes mellitus and their parents] (PubMed id 15949390)9 Zhang S.W....Zhao W.Z. (2005)
    1295. Technology evaluation: Belatacept, Bristol-Myers Squi bb. (PubMed id 16121705)9 Vanhove B. and Soulillou J.P. (2005)
    1296. Peripheral generation and function of CD4+CD25+ regulatory T cells. (PubMed id 15981478)9 Taams L.S. and Akbar A.N. (2005)
    1297. Increased induction of allogeneic-specific cord blood CD4+CD25+ regulatory T (Treg) cells: a comparative study of naive and antigenic-specific cord blood Treg cells. (PubMed id 16338494)9 Chang C.C....Cairo M.S. (2005)
    1298. Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine. (PubMed id 15914560)9 Beyer M....Schultze J.L. (2005)
    1299. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. (PubMed id 15640801)9 Tai X....Singer A. (2005)
    1300. Development and activation of regulatory T cells in the human fetus. (PubMed id 15682453)9 Cupedo T....Spits H. (2005)
    1301. Effects of allergen inhalation and oral glucocorticoid on serum soluble CTLA-4 in allergic asthmatics. (PubMed id 15876307)9 Qin X.J....Zhong X.N. (2005)
    1302. Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. (PubMed id 15374887)9 Godfrey W.R....Porter S.B. (2005)
    1303. CTLA-4 and the genetic predisposition to autoimmunity. (PubMed id 16026134)9 Dallos T. and Kovacs L. (2005)
    1304. Cytokine gene polymorphism in sympathetic ophthalmia. (PubMed id 16249504)9 Atan D....Churchill A.J. (2005)
    1305. A mutant B7-1/Ig fusion protein that selectively binds to CTLA-4 ameliorates anti-tumor DNA vaccination and counters regulatory T cell activity. (PubMed id 15919138)9 Chakrabarti R....Prud'homme G.J. (2005)
    1306. Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206. (PubMed id 16204013)9 Ribas A....Gomez-Navarro J. (2005)
    1307. Suppression of myasthenogenic responses of a T cell line by a dual altered peptide ligand by induction of CD4+CD25+ regulatory cells. (PubMed id 16014414)9 Aruna B.V....Mozes E. (2005)
    1308. Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25- T cells. (PubMed id 15237111)9 Park H.B....Youn J. (2004)
    1309. Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases. (PubMed id 15059264)9 Brunner-Weinzierl M.C....Burmester G.R. (2004)
    1310. CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. (PubMed id 15457445)9 van Amelsfort J.M....Taams L.S. (2004)
    1311. Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants. (PubMed id 15048937)9 Buenafe A.C....Vandenbark A.A. (2004)
    1312. Candidate gene region 2q33 in European families with coeliac disease. (PubMed id 14989710)9 Holopainen P....Partanen J. (2004)
    1313. Cytotoxic T lymphocyte antigen 4 polymorphisms and allergic asthma. (PubMed id 14720255)9 van Oosterhout A.J....Groot P.C. (2004)
    1314. Genomewide search and association studies in a Finnis h celiac disease population: Identification of a novel locus and replication of the HLA and CTLA4 loci. (PubMed id 15386476)9 Rioux J.D....Laakso M. (2004)
    1315. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. (PubMed id 15173208)9 Akdis M....Akdis C.A. (2004)
    1316. Activation requirements for the induction of CD4+CD25+ T cell suppressor function. (PubMed id 14768041)9 Thornton A.M....Shevach E.M. (2004)
    1317. Circulating CD4+CD25+ T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugs. (PubMed id 15024182)9 Putheti P....Huang Y.M. (2004)
    1318. Minor H antigen HA-1-specific regulator and effector CD8+ T cells, and HA-1 microchimerism, in allograft tolerance. (PubMed id 15067036)9 Cai J....Burlingham W.J. (2004)
    1319. CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells. (PubMed id 15322172)9 Makita S....Watanabe M. (2004)
    1320. Interleukin-10-modulated immature dendritic cells control the proinflammatory environment in multiple sclerosis. (PubMed id 15182256)9 Adikari S.B....Link H. (2004)
    1321. Genetic common ground between allergic and autoimmune disease: The role of cytotoxic T-lymphocyte antigen 4. (PubMed id 15316503)9 Holgate S.T. (2004)
    1322. Expression of CD80/CD86 and CTLA-4 mRNA in peripheral blood mononuclear cells of the patients with systemic lupus erythematosus. (PubMed id 15315339)9 Liu W. and Li J. (2004)
    1323. TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes. (PubMed id 15070759)9 Peng Y....Flavell R.A. (2004)
    1324. Overlap between molecular markers expressed by naturally occurring CD4+CD25+ regulatory T cells and antigen specific CD4+CD25+ and CD8+CD28- T suppressor cells. (PubMed id 15556680)9 Scotto L....Suciu-Foca N. (2004)
    1325. The regulation of lymphocyte activation by inhibitory receptors. (PubMed id 15134782)9 Leibson P.J. (2004)
    1326. Immunopathogenesis of acute graft-versus-host disease: implications for novel preventive and therapeutic strategies. (PubMed id 15449032)9 Zeiser R....Finke J. (2004)
    1327. CTLA4 exon 1 polymorphism, rheumatoid arthritis and autoimmune endocrinopathy. (PubMed id 15278761)9 Young-Min S. and Vaidya B. (2004)
    1328. Expression and activity analyses of CTLA4 in peripheral blood lymphocytes in systemic lupus erythematosus patients. (PubMed id 14870914)9 Hirashima M....Hashimoto H. (2004)
    1329. Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma. (PubMed id 14604957)9 Marshall N.A....Vickers M.A. (2004)
    1330. Signalling molecules and cytokine production in T cells of multiple myeloma-increased abnormalities with advancing stage. (PubMed id 14717778)9 Mozaffari F....Osterborg A. (2004)
    1331. CTLA-4 gene polymorphism in promoter and exon-1 regions is not associated with Chinese patients with rheumatoid arthritis. (PubMed id 15045639)9 Liu M.F....Lin T.L. (2004)
    1332. First International Symposium on Melanoma and Other C utaneous Malignancies. (PubMed id 15335320)9 Tarhini A.A. and Agarwala S.S. (2004)
    1333. T regulatory cells in allergy and health: a question of allergen specificity and balance. (PubMed id 15340251)9 Taylor A....Akdis M. (2004)
    1334. Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation. (PubMed id 12753665)9 Haaning Andersen A.D.... Lillevang S.T. (2003)
    1335. Effect of glatiramer acetate (Copaxone) on CD4+CD25high T regulatory cells and their IL-10 production in multiple sclerosis. (PubMed id 14597106)9 Putheti P....Huang Y.M. (2003)
    1336. The impact of costimulatory molecule gene polymorphis ms on clinical outcomes in liver transplantation. (PubMed id 12694064)9 Marder B.A....Murphy B. (2003)
    1337. Association of a rare thyroglobulin gene microsatellite variant with autoimmune thyroid disease. (PubMed id 14557492)9 Collins J.E....Gough S.C. (2003)
    1338. No association of CTLA4 gene with celiac disease in the Basque population. (PubMed id 12883299)9 MartA-n-Pagola A....CastaA+o L. (2003)
    1339. Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes. (PubMed id 12893750)9 Cosmi L....Annunziato F. (2003)
    1340. IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression. (PubMed id 14662842)9 Koenen H.J....Joosten I. (2003)
    1341. Enhancement of gp120-specific immune responses by genetic vaccination with the human immunodeficiency virus type 1 envelope gene fused to the gene coding for soluble CTLA4. (PubMed id 14512535)9 Nayak B.P....Jabbar A.M. (2003)
    1342. TGF-beta: the missing link in CD4+CD25+ regulatory T cell-mediated immunosuppression. (PubMed id 12651220)9 Chen W. and Wahl S.M. (2003)
    1343. Why mapping celiac disease susceptibility genes is so challenging: lessons from the CTLA-4 gene. (PubMed id 12883293)9 Caillat-Zucman S. (2003)
    1344. Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. (PubMed id 12742378)9 Spatz M....Eibl M.M. (2003)
    1345. The contribution of immune regulatory and thyroid specific genes to the etiology of Graves' and Hashimoto's diseases. (PubMed id 14669944)9 Ban Y. and Tomer Y. (2003)
    1346. Generation of antigen-specific, interleukin-10-producing T-cells using dendritic cell stimulation and steroid hormone conditioning. (PubMed id 12967785)9 Dong X....Griffin M.D. (2003)
    1347. TCR subunit specificity of CTLA-4-mediated signaling. (PubMed id 12972512)9 Siu E....Madrenas J. (2003)
    1348. Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigen. (PubMed id 12777848)9 Shirasugi N....Niimi M. (2003)
    1349. [Factors involved in ketoacidosis at the onset of type 1 diabetes in childhood] (PubMed id 12831634)9 MA8ynarski W....Bodalski J. (2003)
    1350. No associations of CTLA-4 and ICAM-1 polymorphisms with psoriasis in the Korean population. (PubMed id 14527743)9 Kim Y.K....Kim T.G. (2003)
    1351. Cytotoxic T lymphocyte antigen-4 gene (CTLA4) polymorphisms in Japanese patients with psoriasis vulgaris. (PubMed id 12850309)9 Tsunemi Y....Sekiya T. (2003)
    1352. [Susceptibility genes for multiple sclerosis] (PubMed id 12962016)9 Fukazawa T....Tashiro K. (2003)
    1353. Fine-tuning of T lymphocytes in autoimmunity: genetic association of CTLA-4 variants and Graves' disease revisited. (PubMed id 14616877)9 Badenhoop K. and Seidl C. (2003)
    1354. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. (PubMed id 12682289)9 Hodi F.S....Dranoff G. (2003)
    1355. No association of two Fas gene polymorphisms with Hashimoto's thyroiditis and Graves' disease. (PubMed id 14585083)9 Stuck B.J....Badenhoop K. (2003)
    1356. Selective blockade of CD28 and not CTLA-4 with a single-chain Fv-alpha1-antitrypsin fusion antibody. (PubMed id 12649149)9 Vanhove B....Soulillou J.P. (2003)
    1357. Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism. (PubMed id 12874215)9 Blazar B.R....Taylor P.A. (2003)
    1358. Secondary immune deficiencies associated with biological therapeutics. (PubMed id 12906774)9 Lee S.J....Kavanaugh A. (2003)
    1359. High GAD65 autoantibody levels in nondiabetic adults are associated with HLA but not with CTLA-4 or INS VNTR. (PubMed id 12653874)9 Rolandsson O....Lernmark A. (2003)
    1360. Prostate cancer: advances in immunotherapy. (PubMed id 12641491)9 Hurwitz A.A....Kwon E.D. (2003)
    1361. Suppressor activity of anergic T cells induced by IL-10-treated human dendritic cells: association with IL-2- and CTLA-4-dependent G1 arrest of the cell cycle regulated by p27Kip1. (PubMed id 12884865)9 Kubsch S....Steinbrink K. (2003)
    1362. The therapeutic potential of costimulatory blockade with CTLA4Ig in rheumatoid arthritis. (PubMed id 12665422)9 Emery P. (2003)
    1363. Genetic dissection of familial autoimmune thyroid diseases using whole genome screening. (PubMed id 12848996)9 Tomer Y. (2002)
    1364. Interleukin-10-mediated regulatory T-cell responses to epitopes on a human red blood cell autoantigen. (PubMed id 12393426)9 Hall A.M....Barker R.N. (2002)
    1365. Population screening of single-nucleotide polymorphisms exemplified by analysis of 8000 alleles. (PubMed id 14599347)9 EkstrA...Giercksky K.E. (2002)
    1366. Expression of the costimulatory molecule BB-1 and its receptors in patients with scleroderma-polymyositis overlap syndrome. (PubMed id 12409186)9 Murata K.Y....Ueno S. (2002)
    1367. Characterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: activation markers. (PubMed id 12220103)9 Anand A....Lydyard P.M. (2002)
    1368. CTLA-4-Ig regulates tryptophan catabolism in vivo. (PubMed id 12368911)9 Grohmann U....Puccetti P. (2002)
    1369. Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28. (PubMed id 12417883)9 Howard T.D....Bleecker E.R. (2002)
    1370. Heavy chain ferritin activates regulatory T cells by induction of changes in dendritic cells. (PubMed id 11964300)9 Gray C.P....Hersey P. (2002)
    1371. Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. (PubMed id 12163566)9 Annunziato F....Romagnani S. (2002)
    1372. No evidence to support CTLA-4 as a susceptibility gene in MS families: the Canadian Collaborative Study. (PubMed id 11880164)9 Dyment D.A....Ebers G.C. (2002)
    1373. Co-stimulatory molecules in islet xenotransplantation: CTLA4Ig treatment in CD40 ligand-deficient mice. (PubMed id 12518898)9 Benda B....Korsgren O. (2002)
    1374. Genetic polymorphism of the human ICOS gene. (PubMed id 11904679)9 Haimila K.E....Holopainen P.M. (2002)
    1375. Treatment of autoimmune hepatitis. (PubMed id 12447708)9 Czaja A.J. (2002)
    1376. Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells. (PubMed id 12438424)9 Levings M.K....Roncarolo M.G. (2002)
    1377. Acquisition of CD80 by human T cells at early stages of activation: functional involvement of CD80 acquisition in T cell to T cell interaction. (PubMed id 12444120)9 Tatari-Calderone Z....Sabzevari H. (2002)
    1378. Re: An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies, by Vaidya et al. (PubMed id 12364657)9 Grennan D.M. (2002)
    1379. The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance. (PubMed id 11920563)9 Eagar T.N....Miller S.D. (2002)
    1380. Targeting T cell costimulation in autoimmune disease. (PubMed id 12223069)9 Stuart R.W. and Racke M.K. (2002)
    1381. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade enhances incidence and severity of experimental autoimmune neuritis in resistant mice. (PubMed id 11282160)9 Zhu J....Ljunggren H. (2001)
    1382. Src kinases Fyn and Lck facilitate the accumulation of phosphorylated CTLA-4 and its association with PI-3 kinase in intracellular compartments of T-cells. (PubMed id 11676481)9 Hu H....Schneider H. (2001)
    1383. Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-ligand and co-stimulatory molecules. (PubMed id 11491535)9 Villinger F....Ansari A.A. (2001)
    1384. A retro-inverso peptide mimic of CD28 encompassing the MYPPPY motif adopts a polyproline type II helix and inhibits encephalitogenic T cells in vitro. (PubMed id 11418697)9 Srinivasan M....Kaumaya P.T. (2001)
    1385. Immunogenetics in PSC. (PubMed id 11492971)9 Donaldson P.T. and Norris S. (2001)
    1386. Linkage analysis of HLA and candidate genes for celiac disease in a North American family-based study. (PubMed id 11737870)9 Neuhausen S.L....Zone J.J. (2001)
    1387. Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. (PubMed id 11390436)9 Levings M.K....Roncarolo M.G. (2001)
    1388. CTLA-4/CD 28 region polymorphisms in children from families with autoimmune hepatitis. (PubMed id 11756004)9 Djilali-Saiah I....Alvarez F. (2001)
    1389. Costimulation blockade promotes the apoptotic death of graft-infiltrating T cells and prolongs survival of hepatic allografts from FLT3L-treated donors. (PubMed id 11685115)9 Li W....Qian S. (2001)
    1390. A regulatory role for cytoplasmic YVKM motif in CTLA-4 inhibition of TCR signaling. (PubMed id 11449357)9 Schneider H....Rudd C.E. (2001)
    1391. CTLA-4 up-regulation plays a role in tolerance mediat ed by CD45. (PubMed id 11135579)9 Fecteau S....Rothstein D.M. (2001)
    1392. Early immune responses accompanying human asymptomatic Ebola infections. (PubMed id 11472407)9 Leroy E.M....Mavoungou E. (2001)
    1393. CTLA-4-mediated inhibition in regulation of T cell re sponses: mechanisms and manipulation in tumor immunotherapy. (PubMed id 11244047)9 Chambers C.A....Allison J.P. (2001)
    1394. Islet cell transplantation tolerance. (PubMed id 11888156)9 Rossini A.A....Stoff J.S. (2001)
    1395. Lack of linkage and association between autoimmune thyroid diseases and the CTLA-4 gene in a large Tunisian family. (PubMed id 11704287)9 Maalej A....Ayadi H. (2001)
    1396. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. (PubMed id 11560997)9 Sutmuller R.P....Melief C.J. (2001)
    1397. The inhibitory effects of transforming growth factor-beta-1 (TGF-beta1) in autoimmune diseases. (PubMed id 10648114)9 Prud'homme G.J. and Piccirillo C.A. (2000)
    1398. Primary structure and functional characterization of a soluble, alternatively spliced form of B7-1. (PubMed id 10843688)9 Faas S.J....Rother R.P. (2000)
    1399. Vitamin D receptor gene polymorphism is associated with Graves' disease in the Japanese population. (PubMed id 11134121)9 Ban Y....Ban Y. (2000)
    1400. A simple method for non-radioactive PCR-SSCP using MDE gel solution and a midi gel format: application for the detection of variants in the GLUT1 and CTLA-4 genes. (PubMed id 10725543)9 Sentinelli F....Baroni M.G. (2000)
    1401. Expression of the co-stimulatory molecule BB-1, the ligands CTLA-4 and CD28 and their mRNAs in chronic inflammatory demyelinating polyneuropathy. (PubMed id 10908195)9 Murata K. and Dalakas M.C. (2000)
    1402. Porcine CTLA4-Ig lacks a MYPPPY motif, binds inefficiently to human B7 and specifically suppresses human CD4+ T cell responses costimulated by pig but not human B7. (PubMed id 10975832)9 Vaughan A.N....Dorling A. (2000)
    1403. Impaired up-regulation of CD86 in B cells of 'type A' common variable immunodeficiency patients. (PubMed id 10760795)9 Denz A....Peter H.H. (2000)
    1404. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. (PubMed id 10899916)9 Read S....Powrie F. (2000)
    1405. Induction of T cell anergy in the absence of CTLA-4/B7 interaction. (PubMed id 10706686)9 Frauwirth K.A....Thompson C.B. (2000)
    1406. LICOS, a primordial costimulatory ligand? (PubMed id 10744980)9 Brodie D....Davis S.J. (2000)
    1407. Role of CD28/B7 costimulation in the dexamethasone-induced suppression of IFN-gamma. (PubMed id 11096449)9 Agarwal S.K. and Marshall G.D. (2000)
    1408. Limited genetic susceptibility to severe Graves' ophthalmopathy: no role for CTLA-4 but evidence for an environmental etiology. (PubMed id 11041456)9 Villanueva R....Davies T.F. (2000)
    1409. New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus. (PubMed id 11196673)9 Matsushita M....Tokunaga K. (2000)
    1410. CTLA-4 in autoimmune diseases--a general susceptibility gene to autoimmunity? (PubMed id 11196709)9 Kristiansen O.P....Pociot F. (2000)
    1411. Systemic lupus erythematosus candidate genes in the Italian population: evidence for a significant association with interleukin-10. (PubMed id 10643707)9 D'Alfonso S....Momigliano-Richardi P. (2000)
    1412. Disparate effects of phorbol esters, CD3 and the costimulatory receptors CD2 and CD28 on RANTES secretion by human T lymphocytes. (PubMed id 11012750)9 Sotsios Y....Ward S.G. (2000)
    1413. B7-1, B7-2 and class II MHC molecules in idiopathic pulmonary fibrosis and bronchiolitis obliterans-organizing pneumonia. (PubMed id 10678620)9 Kaneko Y....Hara N. (2000)
    1414. The role of costimulation in autoimmune demyelination. (PubMed id 10854658)9 Racke M.K....Lovett-Racke A. (2000)
    1415. Role of tolerogen conformation in induction of oral tolerance in experimental autoimmune myasthenia gravis. (PubMed id 11034361)9 Im S.H....Fuchs S. (2000)
    1416. Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis. (PubMed id 10807521)9 Czaja A.J. and Donaldson P.T. (2000)
    1417. CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis. (PubMed id 10782900)9 Agarwal K....Bassendine M.F. (2000)
    1418. Molecular characterization and applications of recombinant scFv antibodies to CD152 co-stimulatory molecule. (PubMed id 10777098)9 Pistillo M.P....Ferrara G.B. (2000)
    1419. Decreased response to recall antigens is associated with depressed costimulatory receptor expression in septic critically ill patients. (PubMed id 10695660)9 Manjuck J....Rackow E.C. (2000)
    1420. Genetic determinants of Graves disease. (PubMed id 11001797)9 Chistyakov D.A....Nosikov V.V. (2000)
    1421. Allergens and irritants transcriptionally upregulate CD80 gene expression in human keratinocytes. (PubMed id 10844549)9 Wakem P....Gaspari A.A. (2000)
    1422. Elevated CTLA-4 expression on CD4 T cells from periodontitis patients stimulated with Porphyromonas gingivalis outer membrane antigen. (PubMed id 10632663)9 Aoyagi T....Hara K. (2000)
    1423. Dinucleotide repeat expansion in the CTLA-4 gene leads to T cell hyper-reactivity via the CD28 pathway in myasthenia gravis. (PubMed id 10713366)9 Huang D....Lefvert A.K. (2000)
    1424. Polymorphism in the promoter and exon 1 of the cytotoxic T lymphocyte antigen-4 gene associated with autoimmune thyroid disease in Koreans. (PubMed id 10907987)9 Park Y.J....Cho B.Y. (2000)
    1425. Inhibition of IgG1 and IgE production by stimulation of the B cell CTLA-4 receptor. (PubMed id 11067906)9 Pioli C....Doria G. (2000)
    1426. Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population. (PubMed id 10655112)9 Anderson D.E....Hafler D.A. (2000)
    1427. The human leukocyte antigen HLA DRB3*020/DQA1*0501 haplotype is associated with Graves' disease in African Americans. (PubMed id 10770195)9 Chen Q.Y....Maclaren N.K. (2000)
    1428. Autoantibodies to T cell costimulatory molecules in systemic autoimmune diseases. (PubMed id 10201965)9 Matsui T....Kato T. (1999)
    1429. A gene therapy or purified CTLA4IgG treatment of experimental allergic encephalomyelitis. (PubMed id 10642893)9 Kawaguchi Y. (1999)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1493 HGNC: 2505 AceView: CTLA4 Ensembl:ENSG00000163599 euGenes: HUgn1493
    ECgene: CTLA4 Kegg: 1493 H-InvDB: CTLA4