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Aliases for CTIF Gene

Aliases for CTIF Gene

  • Cap Binding Complex Dependent Translation Initiation Factor 2 3 5
  • KIAA0427 2 3 4
  • CBP80/20-Dependent Translation Initiation Factor 2 3
  • Gm672 3

External Ids for CTIF Gene

Previous HGNC Symbols for CTIF Gene

  • KIAA0427

Previous GeneCards Identifiers for CTIF Gene

  • GC18P046066

Summaries for CTIF Gene

Entrez Gene Summary for CTIF Gene

  • CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]

GeneCards Summary for CTIF Gene

CTIF (Cap Binding Complex Dependent Translation Initiation Factor) is a Protein Coding gene. GO annotations related to this gene include RNA binding and binding. An important paralog of this gene is MIF4GD.

UniProtKB/Swiss-Prot for CTIF Gene

  • Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTIF Gene

Genomics for CTIF Gene

Regulatory Elements for CTIF Gene

Enhancers for CTIF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F048562 1.2 Ensembl ENCODE 12.4 +24.4 24415 2.3 BCOR ESRRA JUN ZMYM3 RAD21 JUND RBAK IKZF1 ZNF580 HMBOX1 CTIF ENSG00000278983
GH18F048486 0.8 Ensembl ENCODE 11.9 -52.2 -52245 0.4 ZFHX2 HLF GLIS1 BHLHE40 CEBPB CTIF GC18P048479
GH18F048598 1.1 Ensembl ENCODE 11.7 +61.3 61305 3.0 ZFP64 ZNF140 ZNF266 ZNF101 ZNF664 ZNF19 ZNF433 ZNF654 ZBTB11 OVOL3 CTIF RPL17 ENSG00000278983 ENSG00000279629
GH18F048460 0.5 ENCODE 11.3 -77.8 -77758 1.5 CTIF RNA5SP456 GC18M048476 ZBTB7C
GH18F048452 0.9 Ensembl ENCODE 11.3 -84.5 -84547 5.0 MLX ZNF133 ARID4B ZNF48 YY1 FOS SP5 NFYC MIER2 PPARG ZBTB7C CTIF RNA5SP456 GC18M048476
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CTIF on UCSC Golden Path with GeneCards custom track

Promoters for CTIF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001514984 954 3201 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 FOS

Genomic Location for CTIF Gene

Chromosome:
18
Start:
48,539,046 bp from pter
End:
48,863,217 bp from pter
Size:
324,172 bases
Orientation:
Plus strand

Genomic View for CTIF Gene

Genes around CTIF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTIF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTIF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTIF Gene

Proteins for CTIF Gene

  • Protein details for CTIF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43310-CTIF_HUMAN
    Recommended name:
    CBP80/20-dependent translation initiation factor
    Protein Accession:
    O43310
    Secondary Accessions:
    • B3KTR8
    • Q8IVD5

    Protein attributes for CTIF Gene

    Size:
    598 amino acids
    Molecular mass:
    67587 Da
    Quaternary structure:
    • Interacts with NCBP1/CBP80; the interaction is direct. Associates with the eukaryotic translation initiation factor 3 (eIF-3) complex.
    SequenceCaution:
    • Sequence=BAA24857.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG53180.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for CTIF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTIF Gene

Post-translational modifications for CTIF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CTIF Gene

Domains & Families for CTIF Gene

Protein Domains for CTIF Gene

Suggested Antigen Peptide Sequences for CTIF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43310

UniProtKB/Swiss-Prot:

CTIF_HUMAN :
  • Contains 1 MIF4G domain.
  • Belongs to the CTIF family.
Domain:
  • Contains 1 MIF4G domain.
Family:
  • Belongs to the CTIF family.
genes like me logo Genes that share domains with CTIF: view

No data available for Gene Families for CTIF Gene

Function for CTIF Gene

Molecular function for CTIF Gene

UniProtKB/Swiss-Prot Function:
Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD).

Gene Ontology (GO) - Molecular Function for CTIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 19648179
genes like me logo Genes that share ontologies with CTIF: view

Phenotypes for CTIF Gene

genes like me logo Genes that share phenotypes with CTIF: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTIF Gene

Localization for CTIF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTIF Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTIF Gene COMPARTMENTS Subcellular localization image for CTIF gene
Compartment Confidence
cytosol 3
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CTIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0048471 perinuclear region of cytoplasm IEA,IDA 19648179
genes like me logo Genes that share ontologies with CTIF: view

Pathways & Interactions for CTIF Gene

SuperPathways for CTIF Gene

No Data Available

Interacting Proteins for CTIF Gene

Gene Ontology (GO) - Biological Process for CTIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP 19648179
GO:0006417 regulation of translation IEA --
GO:0006446 regulation of translational initiation IMP 19648179
genes like me logo Genes that share ontologies with CTIF: view

No data available for Pathways by source and SIGNOR curated interactions for CTIF Gene

Transcripts for CTIF Gene

Unigene Clusters for CTIF Gene

CBP80/20-dependent translation initiation factor:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTIF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for CTIF Gene

GeneLoc Exon Structure for
CTIF
ECgene alternative splicing isoforms for
CTIF

Expression for CTIF Gene

mRNA expression in normal human tissues for CTIF Gene

Protein differential expression in normal tissues from HIPED for CTIF Gene

This gene is overexpressed in Adrenal (44.9) and Bone (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CTIF Gene



NURSA nuclear receptor signaling pathways regulating expression of CTIF Gene:

CTIF

SOURCE GeneReport for Unigene cluster for CTIF Gene:

Hs.145230

mRNA Expression by UniProt/SwissProt for CTIF Gene:

O43310-CTIF_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with CTIF: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for CTIF Gene

Orthologs for CTIF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTIF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTIF 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia CTIF 34 35
  • 91.95 (n)
cow
(Bos Taurus)
Mammalia CTIF 34 35
  • 90.61 (n)
mouse
(Mus musculus)
Mammalia Ctif 34 16 35
  • 89.06 (n)
rat
(Rattus norvegicus)
Mammalia Ctif 34
  • 87.6 (n)
oppossum
(Monodelphis domestica)
Mammalia CTIF 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTIF 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTIF 34 35
  • 81.53 (n)
lizard
(Anolis carolinensis)
Reptilia CTIF 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctif 34
  • 75.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15060 34
zebrafish
(Danio rerio)
Actinopterygii ctif 34
  • 69.58 (n)
CTIF 35
  • 59 (a)
OneToOne
Species where no ortholog for CTIF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTIF Gene

ENSEMBL:
Gene Tree for CTIF (if available)
TreeFam:
Gene Tree for CTIF (if available)

Paralogs for CTIF Gene

Paralogs for CTIF Gene

genes like me logo Genes that share paralogs with CTIF: view

Variants for CTIF Gene

Sequence variations from dbSNP and Humsavar for CTIF Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
VAR_035749 A breast cancer sample
VAR_035750 A breast cancer sample
rs1000031 -- 48,835,070(-) TACCA(C/T)GAACA intron-variant
rs1004751 -- 48,577,206(-) TCCTG(A/G)GGCGG intron-variant
rs10048289 -- 48,695,626(+) TAATC(A/G)TAGTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CTIF Gene

Variant ID Type Subtype PubMed ID
dgv1596n106 CNV deletion 24896259
dgv1597n106 CNV deletion 24896259
dgv1891e59 CNV duplication 20981092
dgv454e201 CNV deletion 23290073
esv1006969 CNV deletion 20482838
esv1009332 CNV insertion 20482838
esv1253863 CNV insertion 17803354
esv1435704 CNV insertion 17803354
esv1745659 CNV deletion 17803354
esv1976211 CNV deletion 18987734
esv2253454 CNV deletion 18987734
esv2668418 CNV deletion 23128226
esv2717061 CNV deletion 23290073
esv2717063 CNV deletion 23290073
esv2717064 CNV deletion 23290073
esv2717065 CNV deletion 23290073
esv2717067 CNV deletion 23290073
esv2717069 CNV deletion 23290073
esv2717070 CNV deletion 23290073
esv3214871 CNV deletion 24192839
esv3340374 CNV insertion 20981092
esv3341407 CNV duplication 20981092
esv3360048 CNV duplication 20981092
esv33629 CNV gain 17666407
esv3378062 CNV duplication 20981092
esv3431496 CNV insertion 20981092
esv3434394 CNV duplication 20981092
esv3555354 CNV deletion 23714750
esv3583042 CNV loss 25503493
esv3642478 CNV loss 21293372
esv3642481 CNV loss 21293372
esv5388 CNV loss 18987735
esv988938 CNV deletion 20482838
esv992593 CNV insertion 20482838
nsv1058379 CNV loss 25217958
nsv1072800 CNV deletion 25765185
nsv1160522 CNV duplication 26073780
nsv130701 CNV deletion 16902084
nsv2290 CNV insertion 18451855
nsv2291 CNV insertion 18451855
nsv438287 CNV loss 16468122
nsv458065 CNV loss 19166990
nsv458066 CNV loss 19166990
nsv471801 CNV loss 16327809
nsv472763 CNV novel sequence insertion 20440878
nsv473065 CNV novel sequence insertion 20440878
nsv473606 CNV novel sequence insertion 20440878
nsv474890 CNV novel sequence insertion 20440878
nsv475295 CNV novel sequence insertion 20440878
nsv481152 CNV novel sequence insertion 20440878
nsv481257 CNV novel sequence insertion 20440878
nsv481475 CNV novel sequence insertion 20440878
nsv509694 CNV insertion 20534489
nsv510739 CNV deletion 20534489
nsv515638 CNV gain+loss 19592680
nsv517984 CNV loss 19592680
nsv521210 CNV loss 19592680
nsv525699 CNV loss 19592680
nsv576855 CNV loss 21841781
nsv576856 CNV loss 21841781
nsv576857 CNV loss 21841781
nsv576858 CNV loss 21841781
nsv576859 CNV loss 21841781
nsv819050 CNV gain 19587683
nsv833642 CNV gain 17160897
nsv833643 CNV gain 17160897
nsv833644 CNV gain 17160897

Variation tolerance for CTIF Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTIF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTIF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTIF Gene

Disorders for CTIF Gene

Relevant External Links for CTIF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTIF

No disorders were found for CTIF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTIF Gene

Publications for CTIF Gene

  1. A new MIF4G domain-containing protein, CTIF, directs nuclear cap- binding protein CBP80/20-dependent translation. (PMID: 19648179) Kim K.M. … Kim Y.K. (Genes Dev. 2009) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CTIF Gene

Sources for CTIF Gene

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