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Aliases for CTIF Gene

Aliases for CTIF Gene

  • CBP80/20-Dependent Translation Initiation Factor 2 3
  • KIAA0427 2 3 4
  • KIAA0427, 6
  • Gm672 3

External Ids for CTIF Gene

Previous HGNC Symbols for CTIF Gene

  • KIAA0427

Previous GeneCards Identifiers for CTIF Gene

  • GC18P046066

Summaries for CTIF Gene

Entrez Gene Summary for CTIF Gene

  • CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]

GeneCards Summary for CTIF Gene

CTIF (CBP80/20-Dependent Translation Initiation Factor) is a Protein Coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is MIF4GD.

UniProtKB/Swiss-Prot for CTIF Gene

  • Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTIF Gene

Genomics for CTIF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTIF Gene

Start:
48,539,046 bp from pter
End:
48,863,217 bp from pter
Size:
324,172 bases
Orientation:
Plus strand

Genomic View for CTIF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTIF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTIF Gene

No data available for Regulatory Elements for CTIF Gene

Proteins for CTIF Gene

  • Protein details for CTIF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43310-CTIF_HUMAN
    Recommended name:
    CBP80/20-dependent translation initiation factor
    Protein Accession:
    O43310
    Secondary Accessions:
    • B3KTR8
    • Q8IVD5

    Protein attributes for CTIF Gene

    Size:
    598 amino acids
    Molecular mass:
    67587 Da
    Quaternary structure:
    • Interacts with NCBP1/CBP80; the interaction is direct. Associates with the eukaryotic translation initiation factor 3 (eIF-3) complex.
    SequenceCaution:
    • Sequence=BAA24857.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG53180.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for CTIF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTIF Gene

Proteomics data for CTIF Gene at MOPED

Post-translational modifications for CTIF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTIF Gene

No data available for DME Specific Peptides for CTIF Gene

Domains for CTIF Gene

Protein Domains for CTIF Gene

Suggested Antigen Peptide Sequences for CTIF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43310

UniProtKB/Swiss-Prot:

CTIF_HUMAN :
  • O43310
Domain:
  • Contains 1 MIF4G domain.
Family:
  • Belongs to the CTIF family.
genes like me logo Genes that share domains with CTIF: view

No data available for Gene Families for CTIF Gene

Function for CTIF Gene

Molecular function for CTIF Gene

UniProtKB/Swiss-Prot Function: Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD).

Gene Ontology (GO) - Molecular Function for CTIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 19648179
genes like me logo Genes that share ontologies with CTIF: view

Animal Model Products

CRISPR Products

miRNA for CTIF Gene

miRTarBase miRNAs that target CTIF

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTIF

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CTIF Gene

Localization for CTIF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTIF Gene

Cytoplasm, perinuclear region.

Gene Ontology (GO) - Cellular Components for CTIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0048471 perinuclear region of cytoplasm IDA 19648179
genes like me logo Genes that share ontologies with CTIF: view

No data available for Subcellular locations from COMPARTMENTS for CTIF Gene

Pathways for CTIF Gene

SuperPathways for CTIF Gene

No Data Available

Interacting Proteins for CTIF Gene

Gene Ontology (GO) - Biological Process for CTIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP 19648179
GO:0006446 regulation of translational initiation IMP 19648179
genes like me logo Genes that share ontologies with CTIF: view

No data available for Pathways by source for CTIF Gene

Transcripts for CTIF Gene

Unigene Clusters for CTIF Gene

CBP80/20-dependent translation initiation factor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTIF

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CTIF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTIF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for CTIF Gene

GeneLoc Exon Structure for
CTIF
ECgene alternative splicing isoforms for
CTIF

Expression for CTIF Gene

mRNA expression in normal human tissues for CTIF Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CTIF Gene

SOURCE GeneReport for Unigene cluster for CTIF Gene Hs.145230

mRNA Expression by UniProt/SwissProt for CTIF Gene

O43310-CTIF_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with CTIF: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CTIF Gene

Orthologs for CTIF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTIF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTIF 35
  • 99.64 (n)
  • 99.78 (a)
CTIF 36
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTIF 35
  • 90.61 (n)
  • 92.67 (a)
CTIF 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTIF 35
  • 91.95 (n)
  • 95.89 (a)
CTIF 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctif 35
  • 89.06 (n)
  • 93.5 (a)
Ctif 16
Ctif 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTIF 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTIF 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctif 35
  • 87.6 (n)
  • 91.67 (a)
chicken
(Gallus gallus)
Aves CTIF 35
  • 81.53 (n)
  • 87.31 (a)
CTIF 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTIF 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15060 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ctif 35
  • 75.27 (n)
  • 75.99 (a)
zebrafish
(Danio rerio)
Actinopterygii ctif 35
  • 69.58 (n)
  • 69.23 (a)
CTIF 36
  • 59 (a)
OneToOne
Species with no ortholog for CTIF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTIF Gene

ENSEMBL:
Gene Tree for CTIF (if available)
TreeFam:
Gene Tree for CTIF (if available)

Paralogs for CTIF Gene

Paralogs for CTIF Gene

genes like me logo Genes that share paralogs with CTIF: view

Variants for CTIF Gene

Sequence variations from dbSNP and Humsavar for CTIF Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs58964 -- 48,617,066(-) ccagc(C/T)aagaa intron-variant
rs169936 -- 48,630,419(-) TGATT(A/G)AAATC intron-variant
rs172500 -- 48,630,292(-) caacc(C/T)tgagg intron-variant
rs177259 -- 48,638,590(+) ATGGG(C/T)CCATG intron-variant
rs182457 -- 48,639,116(+) GTCTG(C/T)GACGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTIF Gene

Variant ID Type Subtype PubMed ID
nsv833642 CNV Gain 17160897
nsv833643 CNV Gain 17160897
esv2717061 CNV Deletion 23290073
esv2253454 CNV Deletion 18987734
esv5388 CNV Deletion 18987735
esv2717063 CNV Deletion 23290073
nsv471801 CNV Loss 16327809
esv2717064 CNV Deletion 23290073
nsv458065 CNV Loss 19166990
nsv517984 CNV Loss 19592680
nsv909619 CNV Gain 21882294
nsv2290 CNV Insertion 18451855
nsv2291 CNV Insertion 18451855
nsv509694 CNV Insertion 20534489
esv1009332 CNV Insertion 20482838
esv1253863 CNV Insertion 17803354
nsv909620 CNV Gain 21882294
esv2717065 CNV Deletion 23290073
dgv495e201 CNV Deletion 23290073
esv2717067 CNV Deletion 23290073
esv1745659 CNV Deletion 17803354
esv2717069 CNV Deletion 23290073
nsv909621 CNV Gain 21882294
esv1006969 CNV Deletion 20482838
esv33629 CNV Gain 17666407
nsv833644 CNV Gain 17160897
esv992593 CNV Insertion 20482838
esv1435704 CNV Insertion 17803354
nsv521210 CNV Loss 19592680
esv2717070 CNV Deletion 23290073
esv1976211 CNV Deletion 18987734
esv2668418 CNV Deletion 23128226
nsv130701 CNV Loss 16902084
nsv515638 CNV Gain+Loss 19592680
nsv458066 CNV Loss 19166990
nsv525699 CNV Loss 19592680
nsv510739 CNV Loss 20534489
esv988938 CNV Deletion 20482838
nsv438287 CNV Loss 16468122
nsv909622 CNV Loss 21882294
nsv819050 CNV Gain 19587683

Relevant External Links for CTIF Gene

HapMap Linkage Disequilibrium report
CTIF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTIF Gene

Disorders for CTIF Gene

No disorders were found for CTIF Gene.

No data available for UniProtKB/Swiss-Prot for CTIF Gene

Publications for CTIF Gene

  1. A new MIF4G domain-containing protein, CTIF, directs nuclear cap- binding protein CBP80/20-dependent translation. (PMID: 19648179) Kim K.M. … Kim Y.K. (Genes Dev. 2009) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for CTIF Gene

Sources for CTIF Gene

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