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Aliases for CTIF Gene

Aliases for CTIF Gene

  • CBP80/20-Dependent Translation Initiation Factor 2 3 5
  • KIAA0427 2 3 4
  • Gm672 3

External Ids for CTIF Gene

Previous HGNC Symbols for CTIF Gene

  • KIAA0427

Previous GeneCards Identifiers for CTIF Gene

  • GC18P046066

Summaries for CTIF Gene

Entrez Gene Summary for CTIF Gene

  • CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]

GeneCards Summary for CTIF Gene

CTIF (CBP80/20-Dependent Translation Initiation Factor) is a Protein Coding gene. GO annotations related to this gene include RNA binding and binding. An important paralog of this gene is MIF4GD.

UniProtKB/Swiss-Prot for CTIF Gene

  • Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTIF Gene

Genomics for CTIF Gene

Regulatory Elements for CTIF Gene

Enhancers for CTIF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CTIF on UCSC Golden Path with GeneCards custom track

Promoters for CTIF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CTIF on UCSC Golden Path with GeneCards custom track

Genomic Location for CTIF Gene

Chromosome:
18
Start:
48,539,046 bp from pter
End:
48,863,217 bp from pter
Size:
324,172 bases
Orientation:
Plus strand

Genomic View for CTIF Gene

Genes around CTIF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTIF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTIF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTIF Gene

Proteins for CTIF Gene

  • Protein details for CTIF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43310-CTIF_HUMAN
    Recommended name:
    CBP80/20-dependent translation initiation factor
    Protein Accession:
    O43310
    Secondary Accessions:
    • B3KTR8
    • Q8IVD5

    Protein attributes for CTIF Gene

    Size:
    598 amino acids
    Molecular mass:
    67587 Da
    Quaternary structure:
    • Interacts with NCBP1/CBP80; the interaction is direct. Associates with the eukaryotic translation initiation factor 3 (eIF-3) complex.
    SequenceCaution:
    • Sequence=BAA24857.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG53180.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for CTIF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTIF Gene

Proteomics data for CTIF Gene at MOPED

Post-translational modifications for CTIF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTIF Gene

No data available for DME Specific Peptides for CTIF Gene

Domains & Families for CTIF Gene

Protein Domains for CTIF Gene

Suggested Antigen Peptide Sequences for CTIF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43310

UniProtKB/Swiss-Prot:

CTIF_HUMAN :
  • Contains 1 MIF4G domain.
  • Belongs to the CTIF family.
Domain:
  • Contains 1 MIF4G domain.
Family:
  • Belongs to the CTIF family.
genes like me logo Genes that share domains with CTIF: view

No data available for Gene Families for CTIF Gene

Function for CTIF Gene

Molecular function for CTIF Gene

UniProtKB/Swiss-Prot Function:
Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD).

Phenotypes for CTIF Gene

GenomeRNAi human phenotypes for CTIF:
genes like me logo Genes that share phenotypes with CTIF: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTIF Gene

Localization for CTIF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTIF Gene

Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTIF Gene COMPARTMENTS Subcellular localization image for CTIF gene
Compartment Confidence
cytosol 3
nucleus 3
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for CTIF Gene

Pathways & Interactions for CTIF Gene

SuperPathways for CTIF Gene

No Data Available

Interacting Proteins for CTIF Gene

Gene Ontology (GO) - Biological Process for CTIF Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CTIF Gene

Drugs & Compounds for CTIF Gene

No Compound Related Data Available

Transcripts for CTIF Gene

Unigene Clusters for CTIF Gene

CBP80/20-dependent translation initiation factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTIF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for CTIF Gene

GeneLoc Exon Structure for
CTIF
ECgene alternative splicing isoforms for
CTIF

Expression for CTIF Gene

mRNA expression in normal human tissues for CTIF Gene

Protein differential expression in normal tissues from HIPED for CTIF Gene

This gene is overexpressed in Adrenal (44.9) and Bone (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CTIF Gene



SOURCE GeneReport for Unigene cluster for CTIF Gene Hs.145230

mRNA Expression by UniProt/SwissProt for CTIF Gene

O43310-CTIF_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with CTIF: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for CTIF Gene

Orthologs for CTIF Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTIF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTIF 35
  • 90.61 (n)
  • 92.67 (a)
CTIF 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTIF 35
  • 91.95 (n)
  • 95.89 (a)
CTIF 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctif 35
  • 89.06 (n)
  • 93.5 (a)
Ctif 16
Ctif 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTIF 35
  • 99.64 (n)
  • 99.78 (a)
CTIF 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctif 35
  • 87.6 (n)
  • 91.67 (a)
oppossum
(Monodelphis domestica)
Mammalia CTIF 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTIF 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTIF 35
  • 81.53 (n)
  • 87.31 (a)
CTIF 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTIF 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctif 35
  • 75.27 (n)
  • 75.99 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15060 35
zebrafish
(Danio rerio)
Actinopterygii ctif 35
  • 69.58 (n)
  • 69.23 (a)
CTIF 36
  • 59 (a)
OneToOne
Species with no ortholog for CTIF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTIF Gene

ENSEMBL:
Gene Tree for CTIF (if available)
TreeFam:
Gene Tree for CTIF (if available)

Paralogs for CTIF Gene

Paralogs for CTIF Gene

genes like me logo Genes that share paralogs with CTIF: view

Variants for CTIF Gene

Sequence variations from dbSNP and Humsavar for CTIF Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs2277712 - 48,636,678(+) CCCCC(A/C/T)ACAGC reference, missense
VAR_035749 A breast cancer sample
VAR_035750 A breast cancer sample
rs58964 -- 48,617,066(-) ccagc(C/T)aagaa intron-variant
rs169936 -- 48,630,419(-) TGATT(A/G)AAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTIF Gene

Variant ID Type Subtype PubMed ID
nsv833642 CNV Gain 17160897
nsv833643 CNV Gain 17160897
esv2717061 CNV Deletion 23290073
esv2253454 CNV Deletion 18987734
esv5388 CNV Deletion 18987735
esv2717063 CNV Deletion 23290073
nsv471801 CNV Loss 16327809
esv2717064 CNV Deletion 23290073
nsv458065 CNV Loss 19166990
nsv517984 CNV Loss 19592680
nsv909619 CNV Gain 21882294
nsv2290 CNV Insertion 18451855
nsv2291 CNV Insertion 18451855
nsv509694 CNV Insertion 20534489
esv1009332 CNV Insertion 20482838
esv1253863 CNV Insertion 17803354
nsv909620 CNV Gain 21882294
esv2717065 CNV Deletion 23290073
dgv495e201 CNV Deletion 23290073
esv2717067 CNV Deletion 23290073
esv1745659 CNV Deletion 17803354
esv2717069 CNV Deletion 23290073
nsv909621 CNV Gain 21882294
esv1006969 CNV Deletion 20482838
esv33629 CNV Gain 17666407
nsv833644 CNV Gain 17160897
esv992593 CNV Insertion 20482838
esv1435704 CNV Insertion 17803354
nsv521210 CNV Loss 19592680
esv2717070 CNV Deletion 23290073
esv1976211 CNV Deletion 18987734
esv2668418 CNV Deletion 23128226
nsv130701 CNV Loss 16902084
nsv515638 CNV Gain+Loss 19592680
nsv458066 CNV Loss 19166990
nsv525699 CNV Loss 19592680
nsv510739 CNV Loss 20534489
esv988938 CNV Deletion 20482838
nsv438287 CNV Loss 16468122
nsv909622 CNV Loss 21882294
nsv819050 CNV Gain 19587683

Variation tolerance for CTIF Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CTIF Gene

Disorders for CTIF Gene

Relevant External Links for CTIF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTIF

No disorders were found for CTIF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTIF Gene

Publications for CTIF Gene

  1. A new MIF4G domain-containing protein, CTIF, directs nuclear cap- binding protein CBP80/20-dependent translation. (PMID: 19648179) Kim K.M. … Kim Y.K. (Genes Dev. 2009) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Association of SNPs in LCP1 and CTIF with hearing in 11 year old children: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort and the G-EAR consortium. (PMID: 26264041) Harrison S. … Adams J.C. (BMC Med Genomics 2015) 3
  5. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3

Products for CTIF Gene

Sources for CTIF Gene

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