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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CTHRC1 Gene

protein-coding GIFtS: 53
GCID: GC08P104384

collagen triple helix repeat containing 1

Explore 4 diseases affiliated with
CTHRC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Collagen Triple Helix Repeat Containing 1¹ ²
Collagen Triple Helix Repeat-Containing Protein 1²
Protein NMTC1³

External Ids:	HGNC: 18831¹	Entrez Gene: 115908²	Ensembl: ENSG00000164932⁷	OMIM: 610635⁵	UniProtKB: Q96CG8³

Export aliases for CTHRC1 gene to outside databases

Previous GC identifers: GC08P103389 GC08P104451 GC08P104052 GC08P104343 GC08P104344 GC08P104452 GC08P099584

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTHRC1:

This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in

vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal

adenocarcinoma. Alternatively spliced transcript variants have been described. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: CTHR1_HUMAN, Q96CG8

Function: May act as a negative regulator of collagen matrix deposition (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CTHRC1 gene promoter:
GR AML1a NRSF form 1 GR-beta FOXD3 AP-4 NRSF form 2 GR-alpha c-Myc ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CTHRC1 promoter sequence

Search SABiosciences Chromatin IP Primers for CTHRC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTHRC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.3 Ensembl cytogenetic band: 8q22.3 HGNC cytogenetic band: 8q22.3

CTHRC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTHRC1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P104384: view genomic region (about GC identifiers)

Start:	104,383,743 bp from pter	End:	104,395,225 bp from pter
Size:	11,483 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CTHR1_HUMAN, Q96CG8 (See protein sequence)

Recommended Name: Collagen triple helix repeat-containing protein 1 precursor

Size: 243 amino acids; 26224 Da

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Secondary accessions: Q6UW91 Q8IX63

Alternative splicing: 2 isoforms: Q96CG8-1 Q96CG8-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CTHRC1: NX_Q96CG8

Post-translational modifications:

N-glycosylated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96CG8

CTHRC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001243028.1 NP_612464.1

ENSEMBL proteins:

ENSP00000330523 ENSP00000416045 ENSP00000430550 ENSP00000430399

Human Recombinant Protein Products for CTHRC1:

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	Uscn Proteins for CTHRC1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005581	collagen	IEA	--
GO:0005615	extracellular space	IDA	18467647
GO:0005737	cytoplasm	IEA	--

CTHRC1 for ontologies About GeneDecksing

CTHRC1 Antibody Products:

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	Uscn ELISAs and CLIAs for CTHRC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CTHRC1 for domains About GeneDecksing

1 InterPro domain/family:

IPR008160 Collagen

Graphical View of Domain Structure for InterPro Entry Q96CG8

ProtoNet protein and cluster: Q96CG8

2 Blocks protein families:

IPB008160 Collagen triple helix repeat

IPB008161 Collagen helix repeat

UniProtKB/Swiss-Prot: CTHR1_HUMAN, Q96CG8

Similarity: Contains 1 collagen-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CTHR1_HUMAN, Q96CG8

Function: May act as a negative regulator of collagen matrix deposition (By similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005109	frizzled binding	IEA	--
GO:0005515	protein binding	--	--
GO:0017147	Wnt-protein binding	IEA	--

CTHRC1 for ontologies About GeneDecksing

Phenotypes:
8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cthrc1):

embryogenesis	hearing/vestibular/ear	homeostasis/metabolism	liver/biliary system	muscle
nervous system	normal	skeleton

CTHRC1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cthrc1^tm1Vli for CTHRC1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CTHRC1

miRNA Products:		OriGene 3'-UTR Clone: CTHRC1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTHRC1
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CTHRC1 (see all 17):
		hsa-miR-30c hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-let-7c hsa-let-7g hsa-miR-9 hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: CTHRC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTHRC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTHRC1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTHRC1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt signaling network

Wnt signaling network

1.00

Noncanonical Wnt signaling pathway

Noncanonical Wnt signaling pathway

1.00

2 BioSystems Pathways for CTHRC1

	Noncanonical Wnt signaling pathway
	Wnt signaling network

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CTHRC1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for CTHRC1 (ENSP00000330523⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DVL1	ENSP00000368169⁴	STRING: ENSP00000368169
DVL2	ENSP00000005340⁴	STRING: ENSP00000005340
DVL3	ENSP00000316054⁴	STRING: ENSP00000316054
FZD6	ENSP00000351605⁴	STRING: ENSP00000351605
FZD5	ENSP00000354607⁴	STRING: ENSP00000354607

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016477	cell migration	IEA	--
GO:0032092	positive regulation of protein binding	IEA	--
GO:0033690	positive regulation of osteoblast proliferation	IEA	--
GO:0043932	ossification involved in bone remodeling	IEA	--
GO:0045669	positive regulation of osteoblast differentiation	IEA	--

CTHRC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CTHRC1
Search CenterWatch for drugs/clinical trials and news about CTHRC1 / CTHR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CTHRC1 gene (2 alternative transcripts):

NM_001256099.1 NM_138455.3

Unigene Cluster for CTHRC1:

Collagen triple helix repeat containing 1

Hs.405614 [show with all ESTs]

Unigene Representative Sequence: BC021025

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000330295(uc003ylk.3) ENST00000415886(uc011lhq.1) ENST00000520337

ENST00000520880

miRNA Products:		OriGene 3'-UTR Clone: CTHRC1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTHRC1
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CTHRC1 (see all 17):
		hsa-miR-30c hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-let-7c hsa-let-7g hsa-miR-9 hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: CTHRC1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTHRC1

Additional cDNA sequence:

AF395488.1 AK130063.1 AK300273.1 AY136825.1 AY358914.1 BC014245.2 BC021025.1

7 DOTS entries:

DT.413271 DT.91728711 DT.100777173 DT.99954906 DT.97812284 DT.121479179 DT.100777171

24/135 AceView cDNA sequences (see all 135):

AK130063 AA410434 AW236626 AI380885 AI656907 BQ648112 CA868123 AW594685

AA857920 AI074769 CR605392 AI359844 CR596030 NM_138455 AI418593 AW662493

BF000103 AI379443 CR592899 AW071610 AI422726 BE221566 AI218433 AW137377

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CTHRC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTCAGCGT

About this image

CTHRC1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

GABAergic Amacrine Cells

Amacrine, Retina

Heart

Atrioventricular Canal

Atrioventricular Canal Cells

Myocardium

Heart

Endocardium

Cushion Mesenchymal Cells

Endocardium

Ovary

Bone

Caudal Endochondral Bones

Bone

Endochondral Facial Bones

Bone

Stylopod Long Bone

Bone

Thoracic Rib

Bone

Zeugopod Long Bone

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

CD31, CD144 positive cells (Two-step protocol fo...)

Epiblast-like cells (Reconstitution of mo...)

See CTHRC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTHRC1

SOURCE GeneReport for Unigene cluster: Hs.405614

UniProtKB/Swiss-Prot: CTHR1_HUMAN, Q96CG8

Tissue specificity: Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells

SABiosciences Custom PCR Arrays for CTHRC1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CTHRC1 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cthrc1^{1 , 5}	collagen triple helix repeat containing 1^{1, 5}	87.93(n)¹ 94.65(a)¹		15 (15.35 cM)⁵ 68588¹ NM_026778.2¹ NP_081054.1¹ 39076932⁵
chicken (Gallus gallus)	Aves	CTHRC1¹	collagen triple helix repeat containing 1	75.93(n) 86.55(a)		420262 XM_418373.3 XP_418373.3
lizard (Anolis carolinensis)	Reptilia	CTHRC1⁶	--	93(a)	1 ↔ 1	4(13697502-13701759)
zebrafish (Danio rerio)	Actinopterygii	Dr.18064²	Transcribed sequences	72.98(n)		57083753

ENSEMBL Gene Tree for CTHRC1 (if available)
TreeFam Gene Tree for CTHRC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CTHRC1 gene

CTHRC1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for CTHRC1
PGOHUM00000241411

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80192912^1,2		--	99583112(+)	`CTACAA/GTGGAC`	1	--	us2k¹		1		EA	120
rs6984377^1,2	C	--	99583181(+)	`ACTCAA/CAAGTG`	1	--	us2k¹		1		NA	2
rs140937073^1,2		--	104381781(+)	`TTTGTC/GTTTTC`	1	--	us2k¹		0	--	--	--	--
rs3133799^1,2	C,F,A,H	--	104381998(+)	`GTGGGG/ACAAAT`	1	--	us2k¹ tfbs³		13		NS EA NA WA	790
rs3098230^1,2	C,F,O,A,H	--	104382151(-)	`TTAAAG/AAGAGG`	1	--	us2k¹ trp³		100		NS EA NA PA EU CA WA	5246
rs79684208^1,2		--	104382190(+)	`GAAAAC/ACTGCA`	1	--	us2k¹		1		WA	118
rs144912347^1,2		--	104382227(+)	`GCTGAA/CTTTGA`	1	--	us2k¹		0	--	--	--	--
rs147964672^1,2		--	104382307(+)	`TTCCAA/GCCAGT`	1	--	us2k¹		0	--	--	--	--
rs827600^1,2	C,H	--	104382350(-)	`CACCAG/CGTAGG`	1	--	us2k¹		13		NA WA CSA	257
rs191028730^1,2		--	104382516(+)	`AGTTTC/TCTCAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CTHRC1 (104383743 - 104395225 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CTHRC1
1 CNV: 100442
Human Gene Mutation Database (HGMD): CTHRC1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTHRC1

DNA2.0 Custom Variant and Variant Library Synthesis for CTHRC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CTHRC1 for disorders About GeneDecksing

OMIM gene information: 610635 OMIM disorders: --

UniProtKB/Swiss-Prot: CTHR1_HUMAN, Q96CG8

Defects in CTHRC1 may be a cause of Barrett esophagus (BE) [MIM:614266]. A condition characterized by a

metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type

epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of

Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the

esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is

believed to trigger the pathologic changes. Note=Genetic variants in CTHRC1 have been found in individuals with

Barrett esophagus and are thought to contribute to disease susceptibility

4 diseases for CTHRC1: About MalaCards

barrett's esophagus esophagitis adenocarcinoma thyroiditis

Human Genome Epidemiology (HuGE) Navigator: CTHRC1 (2 documents)

Export disorders for CTHRC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CTHRC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CTHRC1)

Utopia: connect your pdf to the dynamic
world of online information

Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. (PubMed id 15618538)^{1, 2, 3} Pyagay P.... Lindner V. (2005)
Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. (PubMed id 21791690)^{1, 2} Orloff M.... Eng C. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Aberrant expression of collagen triple helix repeat containing 1 in human solid cancers. (PubMed id 16778098)^{1, 9} Tang L....Zhou Y. (2006)
The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)¹ Landa I....Robledo M. (2009)
Intracellular localization of Cthrc1 characterizes differentiated smooth muscle. (PubMed id 18467647)¹ Leclair R.J....Lindner V. (2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 115908	HGNC: 18831	AceView: CTHRC1	Ensembl:ENSG00000164932	euGenes: HUgn115908
ECgene: CTHRC1	H-InvDB: CTHRC1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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PharmGKB entry for CTHRC1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CTHRC1	Genetics and Cytogenetics in Oncology and Haematology

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CTHRC1 Gene

collagen triple helix repeat containing 1

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CTHRC1 Gene

collagen triple helix repeat containing 1

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