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CTHRC1 Gene

protein-coding   GIFtS: 54
GCID: GC08P104384

Collagen Triple Helix Repeat Containing 1

  See CTHRC1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Collagen Triple Helix Repeat Containing 11 2
Collagen Triple Helix Repeat-Containing Protein 12
Protein NMTC13

External Ids:    HGNC: 188311   Entrez Gene: 1159082   Ensembl: ENSG000001649327   OMIM: 6106355   UniProtKB: Q96CG83   

Export aliases for CTHRC1 gene to outside databases

Previous GC identifers: GC08P103389 GC08P104451 GC08P104052 GC08P104343 GC08P104344 GC08P104452 GC08P099584


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTHRC1 Gene:
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement
in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal
adenocarcinoma. Alternatively spliced transcript variants have been described. (provided by RefSeq, Jan 2012)

GeneCards Summary for CTHRC1 Gene:
CTHRC1 (collagen triple helix repeat containing 1) is a protein-coding gene. Diseases associated with CTHRC1 include barrett esophagus/esophageal adenocarcinoma, and barrett's esophagus. GO annotations related to this gene include Wnt-protein binding and frizzled binding.

UniProtKB/Swiss-Prot: CTHR1_HUMAN, Q96CG8
Function: May act as a negative regulator of collagen matrix deposition (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTHRC1 gene promoter:
         GR   AML1a   NRSF form 1   GR-beta   FOXD3   AP-4   NRSF form 2   GR-alpha   c-Myc   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTHRC1 promoter sequence
   Search Chromatin IP Primers for CTHRC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTHRC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.3   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22.3

CTHRC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTHRC1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P104384:  view genomic region     (about GC identifiers)

Start:
104,383,743 bp from pter      End:
104,395,225 bp from pter
Size:
11,483 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CTHR1_HUMAN, Q96CG8 (See protein sequence)
Recommended Name: Collagen triple helix repeat-containing protein 1 precursor  
Size: 243 amino acids; 26224 Da
Secondary accessions: G3V141 Q6UW91 Q8IX63
Alternative splicing: 3 isoforms:  Q96CG8-1   Q96CG8-2   Q96CG8-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for CTHRC1: NX_Q96CG8

Explore proteomics data for CTHRC1 at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Glycosylation2 at Asn186

  • See CTHRC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243028.1  NP_612464.1  

    ENSEMBL proteins: 
     ENSP00000330523   ENSP00000416045   ENSP00000430550   ENSP00000430399  

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    antibodies-online proteins for CTHRC1 (7 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008160 Collagen

    Graphical View of Domain Structure for InterPro Entry Q96CG8

    ProtoNet protein and cluster: Q96CG8

    2 Blocks protein domains:
    IPB008160 Collagen triple helix repeat
    IPB008161 Collagen helix repeat


    UniProtKB/Swiss-Prot: CTHR1_HUMAN, Q96CG8
    Similarity: Contains 1 collagen-like domain


    Find genes that share domains with CTHRC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTHR1_HUMAN, Q96CG8
    Function: May act as a negative regulator of collagen matrix deposition (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005109frizzled binding IEA--
    GO:0005515protein binding ----
    GO:0017147Wnt-protein binding IEA--
         
    Find genes that share ontologies with CTHRC1           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cthrc1):
     embryogenesis  hearing/vestibular/ear  homeostasis/metabolism  liver/biliary system  muscle 
     nervous system  normal  skeleton 

    Find genes that share phenotypes with CTHRC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CTHRC1: Cthrc1tm1Vli Cthrc1tm1.2Suna

       genOway: Develop your customized and physiologically relevant rodent model for CTHRC1

    miRNA
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    miRTarBase miRNAs that target CTHRC1:
    hsa-mir-124-3p (MIRT022682), hsa-mir-148b-3p (MIRT019329), hsa-mir-335-5p (MIRT018001)

    Block miRNA regulation of human, mouse, rat CTHRC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTHRC1 (see all 17):
    hsa-miR-30c hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-let-7c hsa-let-7g hsa-miR-9 hsa-miR-30a
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTHR1_HUMAN, Q96CG8: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005581collagen IEA--
    GO:0005615extracellular space IDA18467647
    GO:0005737cytoplasm IEA--
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with CTHRC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTHRC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling network
    Wnt signaling network
    2Noncanonical Wnt signaling pathway
    Noncanonical Wnt signaling pathway


    2 BioSystems Pathways for CTHRC1
        Wnt signaling network
    Noncanonical Wnt signaling pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTHRC1
    Interactions:

        Search GeneGlobe Interaction Network for CTHRC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for CTHRC1 (ENSP000003305234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DVL1ENSP000003681694STRING: ENSP00000368169
    DVL2ENSP000000053404STRING: ENSP00000005340
    DVL3ENSP000003160544STRING: ENSP00000316054
    FZD6ENSP000003516054STRING: ENSP00000351605
    FZD5ENSP000003546074STRING: ENSP00000354607
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    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016477cell migration IEA--
    GO:0032092positive regulation of protein binding IEA--
    GO:0033690positive regulation of osteoblast proliferation IEA--
    GO:0043932ossification involved in bone remodeling IEA--
    GO:0045669positive regulation of osteoblast differentiation IEA--

    Find genes that share ontologies with CTHRC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTHRC1 (CTHR1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTHRC1 gene (2 alternative transcripts): 
    NM_001256099.1  NM_138455.3  

    Unigene Cluster for CTHRC1:

    Collagen triple helix repeat containing 1
    Hs.405614  [show with all ESTs]
    Unigene Representative Sequence: BC021025
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330295(uc003ylk.3) ENST00000415886(uc011lhq.1) ENST00000520337
    ENST00000520880
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CTHRC1 (see all 17):
    hsa-miR-30c hsa-miR-3607-3p hsa-let-7d hsa-miR-30d hsa-let-7c hsa-let-7g hsa-miR-9 hsa-miR-30a
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      QuantiTect SYBR Green Assays in human, mouse, rat CTHRC1
      QuantiFast Probe-based Assays in human, mouse, rat CTHRC1

    Additional mRNA sequence: 

    AF395488.1 AK130063.1 AK300273.1 AY136825.1 AY358914.1 BC014245.2 BC021025.1 

    7 DOTS entries:

    DT.413271  DT.91728711  DT.100777173  DT.99954906  DT.97812284  DT.121479179  DT.100777171 

    Selected AceView cDNA sequences (see all 135):

    BC014245 AI418593 AW594685 CA868123 AW236626 AW137377 AI074769 AI359844 
    BF000103 AI422726 AA857920 BQ648112 AA588673 AW662493 AW071610 CR592899 
    NM_138455 AK130063 BE221566 BE550264 AW316980 AI081084 CR594803 AI656907 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTHRC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTCAGCGT
    CTHRC1 Expression
    About this image


    CTHRC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Osteochondro Mesenchymal Cells Rib
             Zeugopod Long Bone
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Osteochondro Mesenchymal Cells Rib
             Laryngeal Cartilage
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast-like cells
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Pelvic Girdle
    CTHRC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTHRC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.405614

    UniProtKB/Swiss-Prot: CTHR1_HUMAN, Q96CG8
    Tissue specificity: Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CTHRC1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cthrc11 , 5 collagen triple helix repeat containing 11, 5 87.65(n)1
    94.24(a)1
      15 (15.35 cM)5
    685881  NM_026778.21  NP_081054.11 
     390769325 
    chicken
    (Gallus gallus)
    Aves CTHRC11 collagen triple helix repeat containing 1 76.59(n)
    87.44(a)
      420262  XM_418373.4  XP_418373.3 
    lizard
    (Anolis carolinensis)
    Reptilia CTHRC16
    collagen triple helix repeat containing 1
    91(a)
    1 ↔ 1
    4(13697502-13701997)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cthrc11 collagen triple helix repeat containing 1 74.3(n)
    83.18(a)
      548356  XM_002931537.2  XP_002931583.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.180642 Transcribed sequences 72.98(n)    57083753 


    ENSEMBL Gene Tree for CTHRC1 (if available)
    TreeFam Gene Tree for CTHRC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTHRC1 gene

    Find genes that share paralogs with CTHRC1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CTHRC1
    PGOHUM00000241411


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTHRC1 (see all 315)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409370731,2
    --104381781(+) TTTGTC/GTTTTC 1 -- us2k10--------
    rs31337991,2
    C,F,A,H--104381998(+) GTGGGG/ACAAAT 1 -- us2k1 tfbs313Minor allele frequency- A:0.21NS EA NA WA 790
    rs30982301,2
    C,F,O,A,H--104382151(-) TTAAAG/AAGAGG 1 -- us2k1 trp3100Minor allele frequency- A:0.22NS EA NA PA EU CA WA 5246
    rs796842081,2
    F--104382190(+) GAAAAC/ACTGCA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1449123471,2
    --104382227(+) GCTGAA/CTTTGA 1 -- us2k10--------
    rs1479646721,2
    --104382307(+) TTCCAA/GCCAGT 1 -- us2k10--------
    rs1835406271,2
    --104382911(+) TTAGCC/TGGGGC 2 -- us2k10--------
    rs3750889991,2
    C--104383039(+) AAATAC/TAAAAA 2 -- us2k10--------
    rs625255441,2
    C--104383088(+) TACTCG/TGGAGG 2 -- us2k10--------
    rs69892451,2
    C--104383217(+) aaaaaA/Taaaaa 2 -- us2k1 trp30--------

    HapMap Linkage Disequilibrium report for CTHRC1 (104383743 - 104395225 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CTHRC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2625329CNV Deletion19546169

    Human Gene Mutation Database (HGMD): CTHRC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTHRC1
    DNA2.0 Custom Variant and Variant Library Synthesis for CTHRC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610635   
    OMIM disorders: 614266  
    UniProtKB/Swiss-Prot: CTHR1_HUMAN, Q96CG8
  • Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal
    esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett
    esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is
    gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus
    causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed
    to trigger the pathologic changes. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • 3 diseases for CTHRC1:    
    About MalaCards
    barrett esophagus/esophageal adenocarcinoma    barrett's esophagus    adenocarcinoma


    Find genes that share disorders with CTHRC1           About GenesLikeMe

    Genetic Association Database (GAD): CTHRC1
    Human Genome Epidemiology (HuGE) Navigator: CTHRC1 (2 documents)

    Export disorders for CTHRC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTHRC1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with CTHRC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. (PubMed id 15618538)1, 2, 3 Pyagay P.... Lindner V. (Circ. Res. 2005)
    2. Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. (PubMed id 21791690)1, 2 Orloff M.... Eng C. (JAMA 2011)
    3. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    7. Aberrant expression of collagen triple helix repeat containing 1 in human solid cancers. (PubMed id 16778098)1, 9 Tang L....Zhou Y. (Clin. Cancer Res. 2006)
    8. Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells. (PubMed id 23222813)1 Park E.H....Koh S.S. (Carcinogenesis 2013)
    9. N-glycosylation induces the CTHRC1 protein and drives oral cancer cell migration. (PubMed id 23703614)1 Liu G....Kukuruzinska M.A. (J. Biol. Chem. 2013)
    10. The involvement of collagen triple helix repeat containing 1 in muscular dystrophies. (PubMed id 23274062)1 Spector I....Pines M. (Am. J. Pathol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115908 HGNC: 18831 AceView: CTHRC1 Ensembl:ENSG00000164932 euGenes: HUgn115908
    ECgene: CTHRC1 H-InvDB: CTHRC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTHRC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTHRC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTHRC1 gene:
    Search GeneIP for patents involving CTHRC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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