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CTGF Gene

protein-coding GIFtS: 68

GC06M132311

connective tissue growth factor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CCN2 ^¹, ², ³
HCS24 ^², ³
IGFBP8 ^¹, ², ³
MGC102839 ^²
NOV2 ^², ⁵
OTTHUMP00000017213 ^²

Descriptions
Hypertrophic chondrocyte-specific protein 24 ^², ³
connective tissue growth factor ^²
insulin-like growth factor-binding protein 8 ^²

External Ids
HGNC: 2500¹
Entrez Gene: 1490²
UniProtKB: P29279³
Ensembl: ENSG00000118523⁷

Search outside databases for aliases for CTGF gene

Previous GC identifers: GC06M131892 GC06M132116 GC06M132249

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: CTGF_HUMAN, P29279

Function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes

proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent

cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial

cells. Enhances fibroblast growth factor-induced DNA synthesis

Gene Wiki entry for CTGF

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CTGF gene

Entrez Gene cytogenetic band: 6q23.1 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q23.2

CTGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M132311: (about GC identifiers)

Start:	132,311,009 bp from pter
End:	132,314,211 bp from pter
Size:	3,203 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_025741.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CTGF_HUMAN, P29279 (See protein sequence)

Recommended Name: Connective tissue growth factor precursor

Size: 349 amino acids; 38091 Da

Subunit: Monomer

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity). Secreted

(By similarity)

Secondary accessions: Q6LCY0 Q96A79 Q96QX2

Alternative splicing: 2 isoforms: P29279-1 P29279-2

REFSEQ proteins: NP_001892.1

ENSEMBL proteins:

ENSP00000356954

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CTGF)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005578	proteinaceous extracellular matrix	TAS	10809757
GO:0005886	plasma membrane	TAS	10809757

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Antibodies for CTGF:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CTGF
	R&D Systems Antibodies for CTGF (CTGF/CCN2)
	Antibodies from Abcam (CTGF), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CTGF)
	Novus Biologicals Antibodies for CTGF

Assays for CTGF:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P29279

ProtoNet protein and cluster: P29279

5 Blocks protein families:

IPB000867 Insulin-like growth factor-binding protein

IPB000884 Thrombospondin

IPB001007 von Willebrand factor

IPB006207 Cystine knot

IPB006208 Cystine knot domain

UniProtKB/Swiss-Prot: CTGF_HUMAN, P29279

Similarity: Belongs to the CCN family

Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain

Similarity: Contains 1 IGFBP N-terminal domain

Similarity: Contains 1 TSP type-1 domain

Similarity: Contains 1 VWFC domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CTGF)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001901

Applied Biosystems Silencer® siRNAs for CTGF

Sigma-Aldrich siRNA for CTGF

Sigma-Aldrich shRNA Panels and shRNA for CTGF

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001901
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001901
untagged cDNA clone in CMV expression vector: NM_001901

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001901

UniProtKB/Swiss-Prot: CTGF_HUMAN, P29279

Function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes

proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent

cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial

cells. Enhances fibroblast growth factor-induced DNA synthesis

Genatlas biochemistry entry for CTGF:

connective tissue growth factor,homologous to NOV,immediate early response gene

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ctgf):

lethality-prenatal/perinatal

respiratory system

skeleton

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005178	integrin binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0005520	insulin-like growth factor binding	TAS	9371786
GO:0008083	growth factor activity	IEA	--
GO:0008201	heparin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for CTGF (Your Favorite Gene powered by Ingenuity)

Hepatic Fibrosis / Hepatic Stellate Cell Activation
IGF-1 Signaling

GeneDecks CTGF for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CTGF

5/86 Interacting proteins for CTGF (P29279² ENSP00000356954³) via UniProtKB, MINT, and/or STRING (see all 86 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FN1	P02751², ENSP00000323534³	MINT-1781130 MINT-1781181 MINT-1781150 MINT-1780780 MINT-1779933 STRING (score=.987)
ITGA5	P08648², ENSP00000293379³	MINT-1781238 STRING (score=.807)
TGFB1	ENSP00000221930³	STRING (score=.989)
TGFBR2	ENSP00000351905³	STRING (score=.984)
TGFB2	ENSP00000355896³	STRING (score=.983)

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5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001502	cartilage condensation	IEA	--
GO:0001503	ossification	IEA	--
GO:0001525	angiogenesis	IEA	--
GO:0001558	regulation of cell growth	IEA	--
GO:0006260	DNA replication	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CTGF
10/30 Novoseek chemical compound relationships for CTGF gene (see all 30 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tgf beta1	64.80	44	17876891 (6), 15469966 (5), 16469114 (3), 18369694 (3) (see all 12)
des-arg(10)-kallidin	59.70	7	10777533 (3), 15703175 (3)
pd 98,059	43.16	7	15066218 (1), 15955090 (1), 15946238 (1), 16086056 (1) (see all 5)
sp 600125	36.43	6	18922980 (1), 16086056 (1)
geranylgeranyl pyrophosphate	34.80	5	15298857 (1), 11487529 (1)
sphingosylphosphorylcholine	32.69	12	15946238 (5), 17592175 (2)
procollagen	29.65	4	16646035 (1), 16680573 (1), 15994428 (1), 17372041 (1)
oligonucleotide	28.30	22	14996733 (3), 10607888 (3), 12714619 (2), 11278731 (2) (see all 10)
phosphatidylinositol	25.54	6	12760970 (1), 15946238 (1), 15377500 (1), 17498677 (1) (see all 5)
farnesyl diphosphate	22.79	3	15298857 (1), 11487529 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CTGF)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001901

Sigma-Aldrich siRNA for CTGF

Sigma-Aldrich shRNA Panels and shRNA for CTGF

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001901

REFSEQ mRNAs for CTGF gene:

NM_001901.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001901

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001901
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001901
                                 untagged cDNA clone in CMV expression vector: NM_001901

Additional cDNA sequence:

AF127918.1 AK092280.1 AK125220.1 AK290884.1 AK315207.1 BC087839.1 BT019794.1 BT019795.1

CR541734.1 CR541759.1 M92934.1 U14750.1 X78947.1

24 DOTS entries:

DT.100855063 DT.40124189 DT.100866437 DT.95157439 DT.99948760 DT.95157436 DT.100664111 DT.100661459

DT.95193607 DT.91759638 DT.97860643 DT.91973727 DT.121306117 DT.100039679 DT.100661461 DT.102834465

DT.121305940 DT.121305946 DT.121305976 DT.95157443 DT.100647949 DT.100657846 DT.100868213 DT.121306122

24/962 AceView cDNA sequences (see all 962 ):

CA414888 CA450417 AW305059 CA413001 AI913185 CA448629 CA413727 AW005973

AW780245 CA771036 AA305173 BM981417 AA373257 CD678647 CA449044 CA748897

BQ045061 BQ182171 BQ183946 AI720883 CN480101 CN484574 BG927679 BQ425870

highest scoring ESTs for CTGF:

X78947 AI751961 AK125220 AL043964 AL542806 AU129464 AU132344 AU133455 AU134062 AU280594

Unigene Cluster for CTGF:

Connective tissue growth factor

Hs.591346 [show with all ESTs]

Unigene Representative Sequence: NM_001901

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CTGF

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b
SP1:							-						-
SP2:
SP3:							-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for CTGF

1 Ensembl transcript including schematic representation:

ENST00000367976

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CTGF expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CTGF

¹ / ² / ³

4 probe-sets matching CTGF gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
64342_at²^{, 3}	U95-C	1	1.00	1.00	0.98	1.18	AW008273	0.80	1.00	0.91	1
36638_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.82	X78947	1.00	1.00	1.00	1
209101_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M92934	0.80	1.00	0.91	1
209101_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CTGF for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTGCACCTT

SOURCE GeneReport for Unigene cluster: Hs.591346
Expression variation in blood from EXPOLDB for CTGF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CTGF gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	CTGF¹	--	connective tissue growth factor	99.33(n) 98.85(a)	463003 XM_518744.2 XP_518744.2
cow (Bos taurus)	CTGF¹	--	connective tissue growth factor	89.37(n) 90.8(a)	281103 NM_174030.2 NP_776455.1
rat (Rattus norvegicus)	Ctgf¹	--	connective tissue growth factor	88.86(n) 91.93(a)	64032 NM_022266.2 NP_071602.1
mouse (Mus musculus)	Ctgf^{1, 5}	10 (17.00 cM)⁵	connective tissue growth factor^{1, 5}	88.22(n)¹ 91.09(a)¹	14219¹ NM_010217.1¹ NP_034347.1¹ AB039094⁵ AB039095⁵ (see all 22)
chicken (Gallus gallus)	CTGF¹	--	connective tissue growth factor	83.82(n) 88.37(a)	374135 NM_204274.1 NP_989605.1

About this table Species with no ortholog for CTGF

ENSEMBL Gene Tree for CTGF

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for CTGF gene

NOV² WISP2² CYR61²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

5 NCBI SNPs in CTGF are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs9399005^1,2	A,C,F,H	132310657(+)	`TATAAC/TGGCCA`	1	--	ng5¹		4		EU EA WA	416
--	rs12206863^1,2	A	132310735(+)	`AGAGAA/CTTGAA`	1	--	ng5¹		0	--	--	--	--
	rs35846502^1,2	--	132311013(-)	`TTTCTA/TTAAAG`	1	--	ut3¹		0	--	--	--	--
--	rs71731528^1,2	--	132311148(+)	`CTGAT-/CAGCTAT`	1	--	ut3¹		0	--	--	--	--
--	rs35547392^1,2	--	132310575(+)	`TAAAA-/ATTTTT`	1	--	ng5¹		0	--	--	--	--

About this table
The following additional 35 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs928501	rs1931003	rs11966728	rs1931002	rs7748518	rs34609895	rs9493150
rs34385143	rs10872387	rs11575	rs12527379	rs12192573	rs13219571	rs6912547
rs34679197	rs7763896	rs9654640	rs6918698	rs15960	rs34664852	rs34296867
rs9402373	rs7768619	rs15375	rs9493149	rs12526196	rs36015056	rs12527705
rs9388949	rs6917644	rs12529636	rs2151532	rs9483364	rs6918923	rs12191459

HapMap Linkage Disequilibrium images for CTGF (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 121009

10/95 Novoseek disease relationships for CTGF gene (see all 95 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
renal fibrosis	80.50	31	17300978 (3), 12217862 (2), 17376761 (2), 18266088 (2) (see all 19)
skin fibrosis	72.84	9	8618012 (1), 17034590 (1), 18481257 (1), 9550312 (1) (see all 5)
diabetic nephropathies	69.35	42	16373901 (3), 16501850 (3), 15111539 (2), 15882275 (2) (see all 27)
sclerosis systemic	68.88	29	10942593 (7), 17881752 (3), 10648031 (1), 18199873 (1) (see all 14)
conjunctival scarring	68.60	1	15818386 (1)
scleroderma disease	62.52	1	12368229 (1)
pulmonary fibrosis	61.60	18	10648031 (2), 9700098 (2), 18610632 (2), 18525195 (1) (see all 10)
subcutaneous fibrosis	58.62	3	12672195 (1), 12578541 (1), 18481257 (1)
glomerulosclerosis	56.28	11	12846740 (3), 15319369 (1), 16790529 (1), 15012739 (1) (see all 8)
wilms tumor	55.59	19	18922980 (4), 12064632 (1), 15611078 (1), 16287080 (1) (see all 14)

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1 PharmGKB disease relationship for CTGF gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

Human Gene Mutation Database: CTGF
Genetic Association Database: CTGF
Human Genome Epidemiology Navigator: CTGF (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

ASN: Connective Tissue Growth Factor Is A Potential Marker For Progressive Diabetic Nephropathy

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/608 PubMed articles for CTGF gene (see all 608 ):

Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. (PubMed id 1654338)^{2, 3, 4} Bradham D.M.... Grotendorst G.R. (1991)
The amount of calcium-deficient hexagonal hydroxyapatite in aortic valves is influenced by gender and associated with genetic polymorphisms in patients with severe calcific aortic stenosis. (PubMed id 15039132)^{1, 3, 6} Ortlepp J.R....Hoffmann R. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. (PubMed id 12553878)^{3, 4} Ball D.K.... Brigstock D.R. (2003)
Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte- specific gene, on the proliferation and differentiation of chondrocytes in culture. (PubMed id 10614647)^{3, 4} Nakanishi T.... Takigawa M. (2000)
Human connective tissue growth factor is expressed in advanced atherosclerotic lesions. (PubMed id 9054739)^{3, 4} Oemar B.S.... Luescher T.F. (1997)
Connective tissue growth factor. (PubMed id 1293144)^{3, 4} Igarashi A.... Grotendorst G.R. (1992)
Connective tissue growth factor is secreted through the Golgi and is degraded in the endosome. (PubMed id 11697887)^{1, 3} Chen Y....Leask A. (2001)
Expression of connective tissue growth factor in tumor tissues is an independent predictor of poor prognosis in patients with gastric cancer. (PubMed id 18395916)^{1, 3} Liu L.Y....Lv Z.H. (2008)
Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer. (PubMed id 17671176)^{1, 3} Kikuchi R....Imoto I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1490	HGNC: 2500	AceView: CTGF	Ensembl:ENSG00000118523	euGenes: HUgn1490
ECgene: CTGF	H-InvDB: CTGF

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CTGF	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CTGF
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CTGF:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CTGF-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CTGF		Antibodies for CTGF
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CTGF		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (CTGF)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (CTGF)
	Antibodies (CTGF)

Search OriGene for CTGF

Search Tocris compounds for CTGF

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CTGF

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CTGF Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for CTGF

Summaries
for CTGF

Genomic Location
for CTGF

Proteins
for CTGF

Protein Domains/
Families
for CTGF

Gene Function
for CTGF

Pathways & Interactions
for CTGF

Drugs & Compounds
for CTGF

Transcripts
for CTGF

Expression
for CTGF

Orthologs
for CTGF

Paralogs
for CTGF

SNPs/Variants
for CTGF

Disorders & Mutations
for CTGF

Medical News
for CTGF

Publications
for CTGF

Search for CTGF

Genome Databases showing CTGF

Other Databases showing CTGF

Specialized Databases showing CTGF

Licensable Technologies
for CTGF

Services
for CTGF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CTGF Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor CTGF

Summariesfor CTGF

Genomic Locationfor CTGF

Proteinsfor CTGF

Protein Domains/Familiesfor CTGF

Gene Functionfor CTGF

Pathways & Interactionsfor CTGF

Drugs & Compoundsfor CTGF

Transcriptsfor CTGF

Expression for CTGF

Orthologsfor CTGF

Paralogsfor CTGF

SNPs/Variantsfor CTGF

Disorders & Mutationsfor CTGF

Medical Newsfor CTGF

Publicationsfor CTGF

Search for CTGF

Genome Databases showing CTGF

Other Databases showing CTGF

Specialized Databases showing CTGF

Licensable Technologiesfor CTGF

Servicesfor CTGF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CTGF

Summaries
for CTGF

Genomic Location
for CTGF

Proteins
for CTGF

Protein Domains/
Families
for CTGF

Gene Function
for CTGF

Pathways & Interactions
for CTGF

Drugs & Compounds
for CTGF

Transcripts
for CTGF

Expression
for CTGF

Orthologs
for CTGF

Paralogs
for CTGF

SNPs/Variants
for CTGF

Disorders & Mutations
for CTGF

Medical News
for CTGF

Publications
for CTGF

Licensable Technologies
for CTGF

Services
for CTGF