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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTGF Gene

protein-coding   GIFtS: 71
GCID: GC06M132269

Connective Tissue Growth Factor

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Connective Tissue Growth Factor1 2     IGFBP-82 3
Hypertrophic Chondrocyte-Specific Protein 242 3     IGFBP82 3
Insulin-Like Growth Factor-Binding Protein 82 3     CCN Family Member 22 3
CCN22 3     IGF-Binding Protein 82 3
HCS242 3     NOV22 5
IBP-82 3     

External Ids:    HGNC: 25001   Entrez Gene: 14902   Ensembl: ENSG000001185237   OMIM: 1210095   UniProtKB: P292793   

Export aliases for CTGF gene to outside databases

Previous GC identifers: GC06M131892 GC06M132116 GC06M132249 GC06M132311 GC06M129844


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTGF Gene:
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein
plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related
to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of
systemic sclerosis. (provided by RefSeq, Nov 2009)

GeneCards Summary for CTGF Gene: 
CTGF (connective tissue growth factor) is a protein-coding gene. Diseases associated with CTGF include gingival overgrowth, and urethral stricture, and among its related super-pathways are Rac1 Pathway and Ras Pathway. GO annotations related to this gene include integrin binding and growth factor activity. An important paralog of this gene is WISP2.

UniProtKB/Swiss-Prot: CTGF_HUMAN, P29279
Function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation
and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell
types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth
factor-induced DNA synthesis

Gene Wiki entry for CTGF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTGF gene promoter:
         SRF   STAT1   AP-1   ATF-2   SRF (504 AA)   PPAR-gamma1   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTGF promoter sequence
   Search SABiosciences Chromatin IP Primers for CTGF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTGF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.1   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23.2

CTGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTGF gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M132269:  view genomic region     (about GC identifiers)

Start:
132,269,316 bp from pter      End:
132,272,518 bp from pter
Size:
3,203 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CTGF_HUMAN, P29279 (See protein sequence)
Recommended Name: Connective tissue growth factor precursor  
Size: 349 amino acids; 38091 Da
Subunit: Monomer
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity). Secreted (By
similarity)
Secondary accessions: E1P578 Q6LCY0 Q96A79 Q96QX2 Q9UDL6
Alternative splicing: 2 isoforms:  P29279-1   P29279-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CTGF: NX_P29279

Explore proteomics data for CTGF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P29279

  • CTGF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CTGF Protein Expression
    REFSEQ proteins: NP_001892.1  
    ENSEMBL proteins: 
     ENSP00000356954  
    Reactome Protein details: P29279
    Human Recombinant Protein Products for CTGF: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CTGF
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CTGF
    GenScript Custom Purified and Recombinant Proteins Services for CTGF
    Novus Biologicals CTGF Proteins
    Novus Biologicals CTGF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CTGF
    Cloud-Clone Corp. Proteins for CTGF 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IEA--
    GO:0005794Golgi apparatus IDA--
    GO:0005801cis-Golgi network IEA--

    CTGF for ontologies           About GeneDecksing



    CTGF Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CTGF
    R&D Systems Antibodies for CTGF (CTGF/CCN2)
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    GenScript Custom Superior Antibodies Services for CTGF
    Novus Biologicals CTGF Antibodies
    Abcam antibodies for CTGF
    Cloud-Clone Corp. Antibodies for CTGF 
    ThermoFisher Antibody for CTGF
    LSBio Antibodies in human, mouse, rat for CTGF 

    Assay Products for CTGF: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CTGF
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CTGF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CTGF 
    Cloud-Clone Corp. CLIAs for CTGF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR000884 Thrombospondin_1_rpt
     IPR006207 Cys_knot_C
     IPR000867 IGFBP-like
     IPR012395 IGFBP_CNN
     IPR017891 Insulin_GF-bd_Cys-rich_CS

    Graphical View of Domain Structure for InterPro Entry P29279

    ProtoNet protein and cluster: P29279

    5 Blocks protein domains:
    IPB000867 Insulin-like growth factor-binding protein
    IPB000884 Thrombospondin
    IPB001007 von Willebrand factor
    IPB006207 Cystine knot
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: CTGF_HUMAN, P29279
    Similarity: Belongs to the CCN family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 TSP type-1 domain
    Similarity: Contains 1 VWFC domain


    CTGF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTGF_HUMAN, P29279
    Function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation
    and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell
    types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth
    factor-induced DNA synthesis

         Genatlas biochemistry entry for CTGF:
    connective tissue growth factor,homologous to NOV,immediate early response gene

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IEA--
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI16457822
    GO:0005520insulin-like growth factor binding IEA--
    GO:0008083growth factor activity IEA--
         
    CTGF for ontologies           About GeneDecksing


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ctgf):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hearing/vestibular/ear  homeostasis/metabolism  integument  limbs/digits/tail 
     mortality/aging  normal  respiratory system  skeleton  vision/eye 

    CTGF for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CTGF: Ctgftm1Kml Ctgftm1Mae

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CTGF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTGF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTGF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTGF 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CTGF:
    hsa-mir-26a (MIRT004338), hsa-mir-18a (MIRT004174), hsa-mir-124 (MIRT002604)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTGF
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CTGF (see all 21):
    hsa-miR-411* hsa-miR-379* hsa-miR-132 hsa-miR-1297 hsa-miR-133a hsa-miR-3662 hsa-miR-330-3p hsa-miR-212
    SwitchGear 3'UTR luciferase reporter plasmidCTGF 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CTGF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTGF

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CTGF

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CTGF (see all 7)
    OriGene ORF clones in mouse, rat for CTGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTGF (NM_001901)
    Sino Biological Human cDNA Clone for CTGF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTGF
    Sirion Biotech Customized lentivirus for stable overexpression of CTGF 
                         Customized lentivirus expression plasmids for stable overexpression of CTGF 

    Cell Line
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    LifeMap BioReagents: cell line associated with CTGF: PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTGF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CTGF About   (see all 19)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/54 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CTGF (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 BioSystems Pathways for CTGF
        TGF-beta receptor signaling
    amb2 Integrin signaling


    5/8        Reactome Pathways for CTGF (see all 8)
        Generic Transcription Pathway
    Metabolism
    YAP1- and WWTR1 (TAZ)-stimulated gene expression
    Fatty acid, triacylglycerol, and ketone body metabolism
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)


    1         Kegg Pathway  (Kegg details for CTGF):
        Hippo signaling pathway


    CTGF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTGF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for CTGF (P292792, 3 ENSP000003569544) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027512, 3, ENSP000003468394MINT-1781130 MINT-1781181 MINT-1781150 MINT-1780780 MINT-1779933 I2D: score=1 STRING: ENSP00000346839
    ITGA5P086482, 3, ENSP000002933794MINT-1781238 I2D: score=1 STRING: ENSP00000293379
    AP3D1O146173, ENSP000003440554I2D: score=2 STRING: ENSP00000344055
    HSPG2P981603, ENSP000003638274I2D: score=2 STRING: ENSP00000363827
    LRP1Q079543, ENSP000002430774I2D: score=2 STRING: ENSP00000243077
    About this table

    Gene Ontology (GO): 5/46 biological process terms (GO ID links to tree view) (see all 46):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation IEA--
    GO:0001503ossification IEA--
    GO:0001525angiogenesis IEA--
    GO:0001558regulation of cell growth IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--

    CTGF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CTGF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTGF

    1 HMDB Compound for CTGF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aldosterone(+)-Aldosterone (see all 22)52-39-117602195

    10/72 Novoseek inferred chemical compound relationships for CTGF gene (see all 72)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tgf beta1 66 55 17876891 (6), 15469966 (5), 19494553 (4), 16469114 (3) (see all 15)
    des-arg(10)-kallidin 57.8 7 10777533 (3), 15703175 (3)
    vegf 53.9 104 18628999 (6), 18835464 (6), 17355828 (6), 16609965 (5) (see all 41)
    ang ii 53.3 21 17651610 (6), 18633694 (3), 19229829 (3), 16684954 (3) (see all 5)
    sp 600125 48.6 10 19589256 (3), 18922980 (1), 16086056 (1), 19457704 (1)
    pd 98,059 47.8 13 20067105 (2), 15066218 (1), 20238043 (1), 19457704 (1) (see all 9)
    simvastatin 40.4 17 15298857 (4), 15262182 (2), 15677772 (2), 19358180 (1) (see all 10)
    sb 203580 39.6 8 15066218 (1), 18922143 (1), 19457704 (1), 19218111 (1) (see all 5)
    kallidin 35.4 1 16395527 (1)
    aristolochic acid 34.2 4 16075740 (2), 15495827 (1), 19771738 (1)

    Search CenterWatch for drugs/clinical trials and news about CTGF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CTGF gene: 
    NM_001901.2  

    Unigene Cluster for CTGF:

    Connective tissue growth factor
    Hs.410037  [show with all ESTs]
    Unigene Representative Sequence: NM_001901
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367976(uc003qcz.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTGF
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CTGF (see all 21):
    hsa-miR-411* hsa-miR-379* hsa-miR-132 hsa-miR-1297 hsa-miR-133a hsa-miR-3662 hsa-miR-330-3p hsa-miR-212
    SwitchGear 3'UTR luciferase reporter plasmidCTGF 3' UTR sequence
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTGF
    Sirion Biotech Customized lentivirus for stable overexpression of CTGF 
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTGF

    Additional mRNA sequence: 

    AF127918.1 AK092280.1 AK125220.1 AK290884.1 AK315207.1 BC087839.1 BT019794.1 BT019795.1 
    CR541734.1 CR541759.1 M92934.1 U14750.1 X78947.1 

    24/25 DOTS entries (see all 25):

    DT.100855063  DT.40124189  DT.100866437  DT.95157439  DT.95157436  DT.99948760  DT.100664111  DT.100661459 
    DT.95193607  DT.91759638  DT.97860643  DT.91973727  DT.121305973  DT.121306117  DT.100039679  DT.100647949 
    DT.100657846  DT.100661461  DT.102834465  DT.121305940  DT.121305946  DT.121305976  DT.95157443  DT.100868213 

    24/962 AceView cDNA sequences (see all 962):

    BQ182171 AA470417 BQ019724 BG929365 CA412434 AW069663 AA373980 AW069169 
    AA142977 BQ045049 CA412861 CA413669 AI888825 BQ573897 AI095632 AI926732 
    CA414960 BM694955 AA305173 BQ425870 CA415097 AA600878 BQ183935 BQ045016 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CTGF    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
    SP1:                    -                 -                           
    SP2:                                                                  
    SP3:                    -                                             
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for CTGF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTGF expression in normal human tissues (normalized intensities)      CTGF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGCACCTT
    CTGF Expression
    About this image


    CTGF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 20 entries
             Endochondral Preosteoblasts Stylopod Perichondrium
             Endochondral Facial Bones
             skeleton/pectoral girdle and thoracic body wall/sternum   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 18 entries
             Intervertebral Disc Nucleus Pulposus Cells Sacral Intervertebral Disc
             Meckel's Cartilage
             sensory organ/nose/nasal septum   
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Olfactory Bulb   
     
     Limb (Muscoskeletal System)    fully expand to see all 8 entries
             Mesenchymal Condensate Cells Zeugopod
             Pelvic Girdle
     
     Endothelium (Cardiovascular System)    fully expand to see all 7 entries
             Peripheral blood endothelial colony-forming cells
             pulmonary trunk   

    See CTGF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTGF

    SOURCE GeneReport for Unigene cluster: Hs.410037

    UniProtKB/Swiss-Prot: CTGF_HUMAN, P29279
    Tissue specificity: Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested

        SABiosciences Expression via Pathway-Focused PCR Arrays including CTGF (see all 11): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Leukemia in human mouse rat
              Wound Healing in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CTGF gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctgf1 , 5 connective tissue growth factor1, 5 88.6(n)1
    91.38(a)1
      10 (11.84 cM)5
    142191  NM_010217.21  NP_034347.21 
     245954425 
    chicken
    (Gallus gallus)
    Aves CTGF1 connective tissue growth factor 83.82(n)
    88.37(a)
      374135  NM_204274.1  NP_989605.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTGF6
    --
    --
    87(a)
    50(a)
    1 ↔ 1
    possible ortholog
    1(204367598-204372397)
    GL344047.1(94023-98972)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980032 connective tissue growth factor XCTGF 79.84(n)    BC046944.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmzeh15592 hmzeh1559 78.28(n)   321449  CA474518.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ccn6
    Ccn
    18(a)
    1 → many
    3L(17683115-17741939)


    ENSEMBL Gene Tree for CTGF (if available)
    TreeFam Gene Tree for CTGF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTGF gene
    WISP22  NOV2  WISP32  WISP12  CYR612  
    7 SIMAP similar genes for CTGF using alignment to 3 protein entries:     CTGF_HUMAN (see all proteins):
    NOV    WISP1    LIBC    WISP3    CYR61    WISP2
    wisp3 varinat

    CTGF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/149 SNPs in CTGF are shown (see all 149)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0279254
    ----see VAR_0279252 H D mis40--------
    rs562364211,2
    C--129845261(+) CACAC-/AATA  
            
    TTTAC
    1 -- ut310--------
    rs352209391,2
    C,F--132269783(+) TATATAC/-ACACA 1 -- ut311Minor allele frequency- -:0.17NS 532
    rs737791591,2
    C--132269784(+) ATATAC/TACACA 1 -- ut312Minor allele frequency- T:0.10WA NS 542
    rs562236101,2
    C--132269802(+) ACACA-/CAATATT 1 -- ut311Minor allele frequency- CA:0.00NA 2
    rs1393551391,2
    C--132270229(+) AAACA-/TTTTCC 1 -- int10--------
    rs1864309131,2
    --132270281(+) GAAACG/TAACCT 1 -- int10--------
    rs93990051,2
    C,F,A,H--132270291(+) TATAAC/TGGCCA 1 -- int120Minor allele frequency- T:0.26NS EA NA WA 2896
    rs784949501,2
    C,F--132270320(+) AAGGAC/ACAAGT 1 -- int12Minor allele frequency- A:0.04NS NA 664
    rs1911473621,2
    --132270367(+) AGAGAG/TAATTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CTGF (132269316 - 132272518 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CTGF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7968CNV Loss18304495


    Human Gene Mutation Database (HGMD): CTGF
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 121009    OMIM disorders: --

    20/133 diseases for CTGF (see all 133):    About MalaCards
    gingival overgrowth    urethral stricture    scleroderma    renal vascular disease
    nephrogenic systemic fibrosis    paraneoplastic syndromes    collagenous colitis    keloids
    congenital hepatic fibrosis    biliary atresia    diabetic retinopathy    proliferative diabetic retinopathy
    trachoma    hypertrophic scars    ocular cicatricial pemphigoid    urethritis
    nephroblastoma    localized scleroderma    cicatricial pemphigoid    peritonitis

    7 diseases from the University of Copenhagen DISEASES database for CTGF:
    Systemic scleroderma     Pulmonary fibrosis     Nephroblastoma     Kidney disease
    Ureteral disease     Diabetes mellitus     Gingival overgrowth

    CTGF for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/94 Novoseek inferred disease relationships for CTGF gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal fibrosis 82.2 44 19482689 (3), 19955828 (3), 17300978 (3), 12217862 (2) (see all 25)
    skin fibrosis 72.6 9 8618012 (1), 17034590 (1), 18481257 (1), 9550312 (1) (see all 5)
    diabetic nephropathies 72.1 52 16373901 (3), 16501850 (3), 15111539 (2), 15882275 (2) (see all 35)
    sclerosis systemic 69.5 38 10942593 (7), 17881752 (3), 19054818 (2), 20430497 (2) (see all 19)
    scleroderma disease 66.8 1 12368229 (1)
    conjunctival scarring 66.8 1 15818386 (1)
    pulmonary fibrosis 64.6 27 19565505 (4), 10648031 (2), 9700098 (2), 20035857 (2) (see all 12)
    liver fibrosis 58.3 54 20121404 (5), 19243500 (3), 10498649 (3), 18991162 (2) (see all 16)
    glomerulosclerosis 56.5 11 12846740 (3), 15319369 (1), 16790529 (1), 15012739 (1) (see all 8)
    subcutaneous fibrosis 56.3 3 12672195 (1), 12578541 (1), 18481257 (1)

    Genetic Association Database (GAD): CTGF
    Human Genome Epidemiology (HuGE) Navigator: CTGF (21 documents)

    Export disorders for CTGF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTGF gene, integrated from 9 sources (see all 861):
    (articles sorted by number of sources associating them with CTGF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. (PubMed id 1654338)1, 2, 3 Bradham D.M.... Grotendorst G.R. (1991)
    2. Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis. (PubMed id 19243500)1, 4, 9 Kovalenko E....Weiskirchen R. (2009)
    3. Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor. (PubMed id 17602195)1, 6, 9 Gauer S....Goppelt-Struebe M. (2007)
    4. A polymorphism in the CTGF promoter region associated with systemic sclerosis. (PubMed id 17881752)1, 4, 9 Fonseca C....Abraham D.J. (2007)
    5. Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nephropathy. (PubMed id 16501850)1, 4, 9 McKnight A.J.... Maxwell A.P. (2006)
    6. The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. (PubMed id 12553878)1, 2, 9 Ball D.K.... Brigstock D.R. (2003)
    7. Post-mortem pathologic and genetic studies in 'd ead in bed syndrome' cases in type 1 diabetes mellitus. (PubMed id 20004937)1, 4, 9 Tu E....Semsarian C. (2010)
    8. Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population. (PubMed id 19054818)1, 4, 9 Kawaguchi Y....Hara M. (2008)
    9. Association between a CTGF gene polymorphism and syst emic sclerosis in a French population. (PubMed id 20032097)1, 4, 9 Granel B....Chevillard C. (2010)
    10. Analysis of connective tissue growth factor promoter polymorphism in Thai children with biliary atresia. (PubMed id 17375628)1, 4, 9 Sa-nguanmoo P....Poovorawan Y. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1490 HGNC: 2500 AceView: CTGF Ensembl:ENSG00000118523 euGenes: HUgn1490
    ECgene: CTGF Kegg: 1490 H-InvDB: CTGF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTGF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTGF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CTGF gene:
    Search GeneIP for patents involving CTGF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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