Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CTGF Gene

protein-coding   GIFtS: 71
GCID: GC06M132269

Connective Tissue Growth Factor

  See CTGF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Connective Tissue Growth Factor1 2     IGFBP-82 3
Hypertrophic Chondrocyte-Specific Protein 242 3     IGFBP82 3
Insulin-Like Growth Factor-Binding Protein 82 3     CCN Family Member 22 3
CCN22 3     IGF-Binding Protein 82 3
HCS242 3     NOV22 5
IBP-82 3     

External Ids:    HGNC: 25001   Entrez Gene: 14902   Ensembl: ENSG000001185237   OMIM: 1210095   UniProtKB: P292793   

Export aliases for CTGF gene to outside databases

Previous GC identifers: GC06M131892 GC06M132116 GC06M132249 GC06M132311 GC06M129844


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CTGF Gene:
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein
plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related
to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of
systemic sclerosis. (provided by RefSeq, Nov 2009)

GeneCards Summary for CTGF Gene:
CTGF (connective tissue growth factor) is a protein-coding gene. Diseases associated with CTGF include renal fibrosis, and diffuse scleroderma. GO annotations related to this gene include integrin binding and growth factor activity. An important paralog of this gene is WISP2.

UniProtKB/Swiss-Prot: CTGF_HUMAN, P29279
Function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation
and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell
types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth
factor-induced DNA synthesis

Gene Wiki entry for CTGF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTGF gene promoter:
         SRF   STAT1   AP-1   ATF-2   SRF (504 AA)   PPAR-gamma1   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTGF promoter sequence
   Search Chromatin IP Primers for CTGF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTGF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.1   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23.2

CTGF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTGF gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M132269:  view genomic region     (about GC identifiers)

Start:
132,269,316 bp from pter      End:
132,272,518 bp from pter
Size:
3,203 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CTGF_HUMAN, P29279 (See protein sequence)
Recommended Name: Connective tissue growth factor precursor  
Size: 349 amino acids; 38091 Da
Subunit: Monomer
Secondary accessions: E1P578 Q6LCY0 Q96A79 Q96QX2 Q9UDL6
Alternative splicing: 2 isoforms:  P29279-1   P29279-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CTGF: NX_P29279

Explore proteomics data for CTGF at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn28, Thr193, Asn225
  • Modification sites at PhosphoSitePlus

  • See CTGF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001892.1  
    ENSEMBL proteins: 
     ENSP00000356954  
    Reactome Protein details: P29279

    CTGF Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CTGF
    OriGene Protein Over-expression Lysate for CTGF
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CTGF
    GenScript Custom Purified and Recombinant Proteins Services for CTGF
    Novus Biologicals CTGF Proteins
    Novus Biologicals CTGF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CTGF
    Cloud-Clone Corp. Proteins for CTGF

     
    eBioscience Proteins for CTGF:  
                        Human Connective Tissue Growth Factor (CTGF) Recombinant Protein 5 ug

     
    antibodies-online proteins for CTGF (78 products) 

     
    antibodies-online peptides for CTGF

    CTGF Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CTGF
    R&D Systems Antibodies for CTGF (CTGF/CCN2)
    OriGene Antibodies for CTGF
    OriGene Custom Antibody Services for CTGF
    Novus Biologicals CTGF Antibodies
    Abcam antibodies for CTGF
    Cloud-Clone Corp. Antibodies for CTGF
    ThermoFisher Antibody for CTGF
    antibodies-online antibodies for CTGF (123 products) 

    CTGF Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CTGF
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CTGF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CTGF
    Cloud-Clone Corp. CLIAs for CTGF
    Search eBioscience for ELISAs for CTGF 
    antibodies-online kits for CTGF (45 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 8):
     IPR000884 Thrombospondin_1_rpt
     IPR006207 Cys_knot_C
     IPR000867 IGFBP-like
     IPR012395 IGFBP_CNN
     IPR017891 Insulin_GF-bd_Cys-rich_CS

    Graphical View of Domain Structure for InterPro Entry P29279

    ProtoNet protein and cluster: P29279

    5 Blocks protein domains:
    IPB000867 Insulin-like growth factor-binding protein
    IPB000884 Thrombospondin
    IPB001007 von Willebrand factor
    IPB006207 Cystine knot
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: CTGF_HUMAN, P29279
    Similarity: Belongs to the CCN family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 TSP type-1 domain
    Similarity: Contains 1 VWFC domain


    Find genes that share domains with CTGF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTGF_HUMAN, P29279
    Function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation
    and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell
    types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth
    factor-induced DNA synthesis

         Genatlas biochemistry entry for CTGF:
    connective tissue growth factor,homologous to NOV,immediate early response gene

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IEA--
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI16457822
    GO:0005520insulin-like growth factor binding IEA--
    GO:0008083growth factor activity IEA--
         
    Find genes that share ontologies with CTGF           About GenesLikeMe


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ctgf):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  integument  limbs/digits/tail 
     mortality/aging  normal  respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with CTGF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CTGF: Ctgftm1Kml Ctgftm1Mae

       genOway: Develop your customized and physiologically relevant rodent model for CTGF

    miRNA
    Products:
        
    miRTarBase miRNAs that target CTGF:
    hsa-mir-145-5p (MIRT007247), hsa-mir-205-5p (MIRT006936), hsa-mir-26a-5p (MIRT004338), hsa-mir-18a-5p (MIRT004174), hsa-mir-124-3p (MIRT002604), hsa-mir-375 (MIRT019692)

    Block miRNA regulation of human, mouse, rat CTGF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTGF (see all 21):
    hsa-miR-411* hsa-miR-379* hsa-miR-132 hsa-miR-1297 hsa-miR-133a hsa-miR-3662 hsa-miR-330-3p hsa-miR-212
    SwitchGear 3'UTR luciferase reporter plasmidCTGF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CTGF
    Predesigned siRNA for gene silencing in human, mouse, rat CTGF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CTGF

    Clone
    Products:
         
    OriGene clones in human, mouse for CTGF (see all 6)
    OriGene ORF clones in mouse, rat for CTGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTGF (NM_001901)
    Sino Biological Human cDNA Clone for CTGF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTGF

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CTGF
    ESI BIO PureStem Progenitor for CTGF: 
    PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTGF

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12672) for CTGF 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CTGF_HUMAN, P29279: Secreted, extracellular space, extracellular matrix (By similarity). Secreted (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    golgi apparatus4
    plasma membrane4
    cytoskeleton2
    cytosol2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IEA--
    GO:0005794Golgi apparatus IDA--
    GO:0005801cis-Golgi network IEA--

    Find genes that share ontologies with CTGF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CTGF About   (see all 19)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51


    Find genes that share SuperPaths with CTGF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CTGF (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 BioSystems Pathways for CTGF
        amb2 Integrin signaling
    TGF-beta receptor signaling


    2 Reactome Pathways for CTGF
        PPARA activates gene expression
    YAP1- and WWTR1 (TAZ)-stimulated gene expression


    1 Kegg Pathway  (Kegg details for CTGF):
        Hippo signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTGF (see all 11): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Leukemia in human mouse rat
              Wound Healing in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CTGF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTGF (P292791, 2, 3 ENSP000003569544) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027511, 2, 3, ENSP000003468394EBI-2835375,EBI-1220319 MINT-1781130 MINT-1781181 MINT-1781150 MINT-1780780 MINT-1779933 I2D: score=1 STRING: ENSP00000346839
    ITGA5P086482, 3, ENSP000002933794MINT-1781238 I2D: score=1 STRING: ENSP00000293379
    AP3D1O146173, ENSP000003440554I2D: score=2 STRING: ENSP00000344055
    HSPG2P981603, ENSP000003638274I2D: score=2 STRING: ENSP00000363827
    LRP1Q079543, ENSP000002430774I2D: score=2 STRING: ENSP00000243077
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation IEA--
    GO:0001503ossification IEA--
    GO:0001525angiogenesis IEA--
    GO:0001558regulation of cell growth IEA--
    GO:0001934positive regulation of protein phosphorylation IEA--

    Find genes that share ontologies with CTGF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTGF

    1 HMDB Compound for CTGF    About this table
    CompoundSynonyms CAS #PubMed Ids
    Aldosterone(+)-Aldosterone (see all 22)52-39-117602195

    Selected Novoseek inferred chemical compound relationships for CTGF gene (see all 72)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tgf beta1 66 55 17876891 (6), 15469966 (5), 19494553 (4), 16469114 (3) (see all 15)
    des-arg(10)-kallidin 57.8 7 10777533 (3), 15703175 (3)
    vegf 53.9 104 18628999 (6), 18835464 (6), 17355828 (6), 16609965 (5) (see all 41)
    ang ii 53.3 21 17651610 (6), 18633694 (3), 19229829 (3), 16684954 (3) (see all 5)
    sp 600125 48.6 10 19589256 (3), 18922980 (1), 16086056 (1), 19457704 (1)
    pd 98,059 47.8 13 20067105 (2), 15066218 (1), 20238043 (1), 19457704 (1) (see all 9)
    simvastatin 40.4 17 15298857 (4), 15262182 (2), 15677772 (2), 19358180 (1) (see all 10)
    sb 203580 39.6 8 15066218 (1), 18922143 (1), 19457704 (1), 19218111 (1) (see all 5)
    kallidin 35.4 1 16395527 (1)
    aristolochic acid 34.2 4 16075740 (2), 15495827 (1), 19771738 (1)



    Find genes that share compounds with CTGF           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CTGF gene: 
    NM_001901.2  

    Unigene Cluster for CTGF:

    Connective tissue growth factor
    Hs.410037  [show with all ESTs]
    Unigene Representative Sequence: NM_001901
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367976(uc003qcz.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CTGF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTGF (see all 21):
    hsa-miR-411* hsa-miR-379* hsa-miR-132 hsa-miR-1297 hsa-miR-133a hsa-miR-3662 hsa-miR-330-3p hsa-miR-212
    SwitchGear 3'UTR luciferase reporter plasmidCTGF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CTGF
    Predesigned siRNA for gene silencing in human, mouse, rat CTGF
    Clone
    Products:
         
    OriGene clones in human, mouse for CTGF (see all 6)
    OriGene ORF clones in mouse, rat for CTGF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTGF (NM_001901)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTGF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTGF
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CTGF
    OriGene qSTAR qPCR primer pairs in human, mouse for CTGF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTGF
      QuantiTect SYBR Green Assays in human, mouse, rat CTGF
      QuantiFast Probe-based Assays in human, mouse, rat CTGF
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12672) for CTGF 

    Additional mRNA sequence: 

    AF127918.1 AK092280.1 AK125220.1 AK290884.1 AK315207.1 BC087839.1 BT019794.1 BT019795.1 
    CR541734.1 CR541759.1 M92934.1 U14750.1 X78947.1 

    Selected DOTS entries (see all 25):

    DT.100855063  DT.40124189  DT.100866437  DT.95157439  DT.95157436  DT.99948760  DT.100664111  DT.100661459 
    DT.95193607  DT.91759638  DT.97860643  DT.91973727  DT.121305973  DT.121306117  DT.100039679  DT.100647949 
    DT.100657846  DT.100661461  DT.102834465  DT.121305940  DT.121305946  DT.121305976  DT.95157443  DT.100868213 

    Selected AceView cDNA sequences (see all 962):

    BQ045067 CF272205 CA412255 AA345317 AI754562 AI754383 AA470417 BQ183946 
    AU118253 AI753603 CA447914 CA413439 CA413949 AA363567 AA480642 CA414037 
    AI343580 BQ182171 AW339089 BG057771 AI679345 CN481029 AW305059 BF981890 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CTGF    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
    SP1:                    -                 -                           
    SP2:                                                                  
    SP3:                    -                                             
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for CTGF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CTGF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGCACCTT
    CTGF Expression
    About this image


    CTGF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 30) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Endochondral Preosteoblasts Zeugopod Perichondrium
             Endochondral Facial Bones
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             Meckel's Cartilage
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Left Ventricle
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Chondrocytes Tracheal Cartilage
             Trachea
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Inner Cell Mass Cells Inner Cell Mass
             Human embryonic stem cells (family)
    CTGF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTGF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.410037

    UniProtKB/Swiss-Prot: CTGF_HUMAN, P29279
    Tissue specificity: Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CTGF (see all 11): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Leukemia in human mouse rat
              Wound Healing in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CTGF
    OriGene qSTAR qPCR primer pairs in human, mouse for CTGF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTGF
    QuantiTect SYBR Green Assays in human, mouse, rat CTGF
    QuantiFast Probe-based Assays in human, mouse, rat CTGF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTGF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CTGF gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctgf1 , 5 connective tissue growth factor1, 5 88.6(n)1
    91.38(a)1
      10 (11.84 cM)5
    142191  NM_010217.21  NP_034347.21 
     245954425 
    chicken
    (Gallus gallus)
    Aves CTGF1 connective tissue growth factor 83.82(n)
    88.37(a)
      374135  NM_204274.1  NP_989605.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTGF6
    connective tissue growth factor
    88(a)
    1 ↔ 1
    1(204367598-204372397)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980032 connective tissue growth factor XCTGF 79.84(n)    BC046944.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmzeh15592 hmzeh1559 78.28(n)   321449  CA474518.1 


    ENSEMBL Gene Tree for CTGF (if available)
    TreeFam Gene Tree for CTGF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CTGF gene
    WISP22  NOV2  WISP32  WISP12  CYR612  
    7 SIMAP similar genes for CTGF using alignment to 3 protein entries:     CTGF_HUMAN (see all proteins):
    NOV    WISP1    LIBC    WISP3    CYR61    WISP2
    wisp3 varinat

    Find genes that share paralogs with CTGF           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CTGF (see all 149)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs562364211,2
    C--129845261(+) CACAC-/AATA  
            
    TTTAC
    1 -- ut310--------
    rs352209391,2
    C,F--132269783(+) TATATAC/-ACACA 1 -- ut311Minor allele frequency- -:0.17NS 532
    rs737791591,2
    C--132269784(+) ATATAC/TACACA 1 -- ut312Minor allele frequency- T:0.10WA NS 542
    rs562236101,2
    C--132269802(+) ACACA-/CAATATT 1 -- ut311Minor allele frequency- CA:0.00NA 2
    rs1393551391,2
    C--132270229(+) AAACA-/TTTTCC 1 -- int10--------
    rs1864309131,2
    --132270281(+) GAAACG/TAACCT 1 -- int10--------
    rs93990051,2
    C,F,A,H--132270291(+) TATAAC/TGGCCA 1 -- int120Minor allele frequency- T:0.26NS EA NA WA 2896
    rs784949501,2
    C,F--132270320(+) AAGGAC/ACAAGT 1 -- int12Minor allele frequency- A:0.04NS NA 664
    rs1911473621,2
    --132270367(+) AGAGAG/TAATTG 1 -- int10--------
    rs122068631,2
    C,F,A--132270369(+) AGAGAA/CTTGAA 1 -- int16Minor allele frequency- C:0.12NA NS EA 798

    HapMap Linkage Disequilibrium report for CTGF (132269316 - 132272518 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CTGF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7968CNV Loss18304495

    Human Gene Mutation Database (HGMD): CTGF
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTGF
    DNA2.0 Custom Variant and Variant Library Synthesis for CTGF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 121009    OMIM disorders: --

    20 diseases for CTGF:    
    About MalaCards
    renal fibrosis    diffuse scleroderma    limited scleroderma    scleroderma
    gingival overgrowth    paraneoplastic syndromes    nephrogenic systemic fibrosis    ureteral disease
    urethral stricture    trachoma    collagenous colitis    congenital hepatic fibrosis
    ocular cicatricial pemphigoid    proliferative diabetic retinopathy    biliary atresia    diabetic retinopathy
    nephroblastoma    pulmonary fibrosis    diabetic nephropathy    malaria

    7 diseases from the University of Copenhagen DISEASES database for CTGF:
    Systemic scleroderma     Pulmonary fibrosis     Nephroblastoma     Kidney disease
    Ureteral disease     Diabetes mellitus     Gingival overgrowth

    Find genes that share disorders with CTGF           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CTGF gene (see all 94)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal fibrosis 82.2 44 19482689 (3), 19955828 (3), 17300978 (3), 12217862 (2) (see all 25)
    skin fibrosis 72.6 9 8618012 (1), 17034590 (1), 18481257 (1), 9550312 (1) (see all 5)
    diabetic nephropathies 72.1 52 16373901 (3), 16501850 (3), 15111539 (2), 15882275 (2) (see all 35)
    sclerosis systemic 69.5 38 10942593 (7), 17881752 (3), 19054818 (2), 20430497 (2) (see all 19)
    scleroderma disease 66.8 1 12368229 (1)
    conjunctival scarring 66.8 1 15818386 (1)
    pulmonary fibrosis 64.6 27 19565505 (4), 10648031 (2), 9700098 (2), 20035857 (2) (see all 12)
    liver fibrosis 58.3 54 20121404 (5), 19243500 (3), 10498649 (3), 18991162 (2) (see all 16)
    glomerulosclerosis 56.5 11 12846740 (3), 15319369 (1), 16790529 (1), 15012739 (1) (see all 8)
    subcutaneous fibrosis 56.3 3 12672195 (1), 12578541 (1), 18481257 (1)

    Genetic Association Database (GAD): CTGF
    Human Genome Epidemiology (HuGE) Navigator: CTGF (21 documents)

    Export disorders for CTGF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CTGF gene, integrated from 10 sources (see all 878):
    (articles sorted by number of sources associating them with CTGF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. (PubMed id 1654338)1, 2, 3 Bradham D.M.... Grotendorst G.R. (J. Cell Biol. 1991)
    2. Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis. (PubMed id 19243500)1, 4, 9 Kovalenko E....Weiskirchen R. (J. Viral Hepat. 2009)
    3. Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor. (PubMed id 17602195)1, 6, 9 Gauer S....Goppelt-Struebe M. (Nephrol. Dial. Transplant. 2007)
    4. A polymorphism in the CTGF promoter region associated with systemic sclerosis. (PubMed id 17881752)1, 4, 9 Fonseca C....Abraham D.J. (N. Engl. J. Med. 2007)
    5. Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nephropathy. (PubMed id 16501850)1, 4, 9 McKnight A.J.... Maxwell A.P. (J. Hum. Genet. 2006)
    6. The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. (PubMed id 12553878)1, 2, 9 Ball D.K.... Brigstock D.R. (J. Endocrinol. 2003)
    7. Post-mortem pathologic and genetic studies in &quot;dead in bed syndrome&quot; cases in type 1 diabetes mellitus. (PubMed id 20004937)1, 4, 9 Tu E....Semsarian C. (Hum. Pathol. 2010)
    8. Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population. (PubMed id 19054818)1, 4, 9 Kawaguchi Y....Hara M. (Ann. Rheum. Dis. 2009)
    9. Association between a CTGF gene polymorphism and systemic sclerosis in a French population. (PubMed id 20032097)1, 4, 9 Granel B....Chevillard C. (J. Rheumatol. 2010)
    10. Analysis of connective tissue growth factor promoter polymorphism in Thai children with biliary atresia. (PubMed id 17375628)1, 4, 9 Sa-nguanmoo P....Poovorawan Y. (J Med Assoc Thai 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1490 HGNC: 2500 AceView: CTGF Ensembl:ENSG00000118523 euGenes: HUgn1490
    ECgene: CTGF Kegg: 1490 H-InvDB: CTGF

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CTGF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTGF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CTGF gene:
    Search GeneIP for patents involving CTGF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CTGF
     
     EMD Millipore genomic analysis products

      
     Antibodies for CTGF (CTGF/CCN2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CTGF   OriGene RNAi products in human, mouse, rat for CTGF  
     OriGene qPCR primer pairs and template standards for CTGF   OriGene Protein Over-expression Lysate for CTGF  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CTGF  
     OriGene qSTAR qPCR primer pairs in human, mouse for CTGF   OriGene Purified Protein for CTGF  
     OriGene ORF clones in mouse, rat for CTGF   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CTGF   OriGene Custom Protein Services for CTGF  

     
     
     Block miRNA regulation of human, mouse, rat CTGF using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CTGF
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTGF Predesigned siRNA for gene silencing in human, mouse, rat CTGF
     QuantiFast Probe-based Assays in human, mouse, rat CTGF QuantiTect SYBR Green Assays in human, mouse, rat CTGF
     PCR Arrays including human, mouse, rat CTGF Search Chromatin IP Primers for CTGF
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTGF  GeneGlobe Interaction Network for CTGF
     Regulatory tfbs in CTGF promoter
     GenScript Custom Purified and Recombinant Proteins Services for CTGF GenScript cDNA clones with any tag delivered in your preferred vector for CTGF
     GenScript Custom Assay Services for CTGF GenScript Custom overexpressing Cell Line Services for CTGF
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CTGF
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CTGF
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CTGF antibodies
     CTGF proteins
     CTGF lysates
     Antibodies for CTGF
     See all of Abcam's Antibodies, Kits and Proteins for CTGF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CTGF
     Proteins for CTGF
     Antibodies for CTGF
     ELISAs for CTGF
     CLIAs for CTGF



     PureStem Progenitor for CTGF: PureStem ES-210, Ecto-ntu Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTGF
     SwitchGear 3'UTR luciferase reporter plasmids for CTGF
     SwitchGear Promoter luciferase reporter plasmids for CTGF
     ThermoFisher Antibody for CTGF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTGF
     Browse compounds at ApexBio
     Search Addgene for plasmids for CTGF
     eBioscience proteins for CTGF (Human Connective Tissue Growth Factor (CTGF) Recombinant Protein 5 ug)
      Search eBioscience for elisas for CTGF
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CTGF
     antibodies-online antibodies for CTGF (123 products)
     antibodies-online kits for CTGF (45 products)
     antibodies-online peptides for CTGF
     antibodies-online proteins for CTGF (78 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CTGF gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4