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CTF1 Gene

protein-coding   GIFtS: 57
GCID: GC16P030910

Cardiotrophin 1

  See CTF1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cardiotrophin 11 2
CT-12 3
CT12 5
Cardiophin 12
cardiotrophin-12

External Ids:    HGNC: 24991   Entrez Gene: 14892   Ensembl: ENSG000001502817   OMIM: 6004355   UniProtKB: Q166193   

Export aliases for CTF1 gene to outside databases

Previous GC identifers: GC16M9B0154 GC16P031404 GC16P030904 GC16P030943 GC16P030815 GC16P028471


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTF1 Gene:
The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has
been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Dec 2008)

GeneCards Summary for CTF1 Gene:
CTF1 (cardiotrophin 1) is a protein-coding gene. Diseases associated with CTF1 include neonatal stroke, and motor neuron disease. GO annotations related to this gene include leukemia inhibitory factor receptor binding and cytokine activity.

UniProtKB/Swiss-Prot: CTF1_HUMAN, Q16619
Function: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTF1 gene promoter:
         STAT1   p53   STAT1beta   NF-kappaB   STAT1alpha   STAT3   Zic3   NF-kappaB1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTF1 promoter sequence
   Search Chromatin IP Primers for CTF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

CTF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTF1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P030910:  view genomic region     (about GC identifiers)

Start:
30,907,928 bp from pter      End:
30,914,881 bp from pter
Size:
6,954 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTF1_HUMAN, Q16619 (See protein sequence)
Recommended Name: Cardiotrophin-1  
Size: 201 amino acids; 21227 Da
Secondary accessions: A8MVX4 Q5U5Y7
Alternative splicing: 2 isoforms:  Q16619-1   Q16619-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CTF1: NX_Q16619

Explore proteomics data for CTF1 at MOPED


See CTF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001136016.1  NP_001321.1  

ENSEMBL proteins: 
 ENSP00000279804   ENSP00000378465  

CTF1 Human Recombinant Protein Products:

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Sino Biological Cell Lysate for CTF1
ProSpec Recombinant Protein for CTF1
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Search eBioscience for Proteins for CTF1 

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ThermoFisher Antibodies for CTF1
LSBio Antibodies in human, mouse, rat for CTF1

CTF1 Assay Products:

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Search eBioscience for ELISAs for CTF1 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR012351 4_helix_cytokine_core
 IPR009079 4_helix_cytokine-like_core
 IPR010681 PRF

Graphical View of Domain Structure for InterPro Entry Q16619

ProtoNet protein and cluster: Q16619

UniProtKB/Swiss-Prot: CTF1_HUMAN, Q16619
Similarity: Belongs to the IL-6 superfamily


Find genes that share domains with CTF1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CTF1_HUMAN, Q16619
Function: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor

     Genatlas biochemistry entry for CTF1:
cardiotrophin 1,21.5kDa,interleukin-6 cytokine family member,expressed in adult human heart,skeletal
muscle,ovary,colon,testis,fetal kidney and lung,also expressed in dilated cardiomyopathy

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005125cytokine activity IEA--
GO:0005146leukemia inhibitory factor receptor binding IEA--
     
Find genes that share ontologies with CTF1           About GenesLikeMe


Phenotypes:
     7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ctf1):
 adipose tissue  behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body 
 homeostasis/metabolism  nervous system 

Find genes that share phenotypes with CTF1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Ctf1tm1Msd for CTF1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTF1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTF1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTF1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTF1

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat CTF1 using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate CTF1:
hsa-miR-548a-3p hsa-miR-214 hsa-miR-520d-5p hsa-miR-3613-3p hsa-miR-524-5p hsa-miR-548e hsa-miR-32* hsa-miR-761
SwitchGear 3'UTR luciferase reporter plasmidCTF1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CTF1
Predesigned siRNA for gene silencing in human, mouse, rat CTF1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CTF1

Clone
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OriGene clones in human, mouse for CTF1 (see all 9)
OriGene ORF clones in mouse, rat for CTF1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): CTF1 (NM_001142544)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTF1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTF1

Cell Line
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GenScript Custom overexpressing Cell Line Services for CTF1
Browse ESI BIO Cell Lines and PureStem Progenitors for CTF1 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTF1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CTF1_HUMAN, Q16619: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
cytosol2
nucleus2
cytoskeleton1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS7862649
GO:0005615extracellular space IEA--

Find genes that share ontologies with CTF1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CTF1 About   (see all 6)  
See pathways by source

SuperPathContained pathways About
1NFAT and Cardiac Hypertrophy
NFAT and Cardiac Hypertrophy0.42
Signaling Involved in Cardiac Hypertrophy0.42
2Apoptotic Pathways in Synovial Fibroblasts
ERK5 Signaling0.61
3PEDF Induced Signaling
Cytokine-cytokine receptor interaction0.43
4Physiological and Pathological Hypertrophy of the Heart
Physiological and Pathological Hypertrophy of the Heart
5MicroRNAs in cardiomyocyte hypertrophy
MicroRNAs in cardiomyocyte hypertrophy


Find genes that share SuperPaths with CTF1           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CTF1
    ERK5 Signaling
NFAT and Cardiac Hypertrophy
Signaling Involved in Cardiac Hypertrophy

2 BioSystems Pathways for CTF1
    MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the Heart



2 Kegg Pathways  (Kegg details for CTF1):
    Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CTF1: 
          cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Common Cytokines in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CTF1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for CTF1 (Q166193 ENSP000002798044) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
IL6STP401893, ENSP000003387994I2D: score=2 STRING: ENSP00000338799
LIFRP427023, ENSP000002634094I2D: score=1 STRING: ENSP00000263409
TAF7ENSP000003127094STRING: ENSP00000312709
About this table

Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007267cell-cell signaling TAS7862649
GO:0007399nervous system development TAS7738033
GO:0007517muscle organ development TAS7862649
GO:0008283cell proliferation TAS7738033
GO:0008284positive regulation of cell proliferation TAS7862649

Find genes that share ontologies with CTF1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CTF1

2 Novoseek inferred chemical compound relationships for CTF1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gp 130 93.6 37 17885560 (2), 10843995 (1), 16920889 (1), 17525365 (1) (see all 30)
il 11 72.9 1 8605875 (1)



Find genes that share compounds with CTF1           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CTF1 gene (2 alternative transcripts): 
NM_001142544.1  NM_001330.3  

Unigene Cluster for CTF1:

Cardiotrophin 1
Hs.483811  [show with all ESTs]
Unigene Representative Sequence: BC036787
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000279804(uc002dzx.3 uc002dzw.3) ENST00000395019
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CTF1 using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate CTF1:
hsa-miR-548a-3p hsa-miR-214 hsa-miR-520d-5p hsa-miR-3613-3p hsa-miR-524-5p hsa-miR-548e hsa-miR-32* hsa-miR-761
SwitchGear 3'UTR luciferase reporter plasmidCTF1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CTF1
Predesigned siRNA for gene silencing in human, mouse, rat CTF1
Clone
Products:
     
OriGene clones in human, mouse for CTF1 (see all 9)
OriGene ORF clones in mouse, rat for CTF1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): CTF1 (NM_001142544)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTF1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTF1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CTF1
OriGene qSTAR qPCR primer pairs in human, mouse for CTF1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTF1
  QuantiTect SYBR Green Assays in human, mouse, rat CTF1
  QuantiFast Probe-based Assays in human, mouse, rat CTF1

Additional mRNA sequence: 

BC036787.1 BC049822.1 BC064416.1 U43030.1 

2 DOTS entries:

DT.455000  DT.97766569 

Selected AceView cDNA sequences (see all 31):

BC049822 R48250 BM973002 BC064416 BC036787 BM853228 BX102298 U43030 
BM703635 NM_001330 BQ923694 AA928268 BG741447 BU730083 AI918317 BM717303 
AI086477 BG149728 AI933282 AA708512 BG753490 BM921528 AA570388 AI870644 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CTF1    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:              -                     
SP2:              -                     
SP3:                                    


ECgene alternative splicing isoforms for CTF1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CTF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGTACATCTC
CTF1 Expression
About this image


CTF1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Blood (Hematopoietic System)
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
 
 Eye (Sensory Organs)
CTF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CTF1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.483811

UniProtKB/Swiss-Prot: CTF1_HUMAN, Q16619
Tissue specificity: Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney,
pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or
peripheral blood leukocytes

    Pathway & Disease-focused RT2 Profiler PCR Arrays including CTF1: 
          cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
          Cytokines & Chemokines in human mouse rat
          Common Cytokines in human mouse rat
          Inflammatory Response & Autoimmunity 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CTF1
OriGene qSTAR qPCR primer pairs in human, mouse for CTF1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTF1
QuantiTect SYBR Green Assays in human, mouse, rat CTF1
QuantiFast Probe-based Assays in human, mouse, rat CTF1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTF1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for CTF1 gene from Selected species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ctf11 , 5 cardiotrophin 11, 5 82.26(n)1
79.1(a)1
  7 (69.69 cM)5
130191  NM_007795.11  NP_031821.11 
 1277127365 


ENSEMBL Gene Tree for CTF1 (if available)
TreeFam Gene Tree for CTF1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CTF1 (see all 113)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs557682651,2
C--30906997(+) AATTG-/TCTG  
        
CTCAC
2 -- us2k10--------
rs1914924771,2
--30907404(+) TGTTAC/TTAGGC 2 -- us2k10--------
rs792348991,2
C--30907462(+) GACAA-/GTGAGA 2 -- us2k10--------
rs792333011,2
C--30907689(+) GAACAC/TTGGGC 2 -- us2k10--------
rs1482093881,2
C--30907758(+) GCCTTC/TCCCCT 2 -- us2k10--------
rs1400939011,2
--30907790(+) CCCCAC/TGGACG 2 -- us2k10--------
rs22347101,2
C--30907835(+) AAAAGA/G/TGGGGG 2 -- us2k10--------
rs1870883451,2
C--30907838(+) AGGGGA/GGGTAG 2 -- us2k10--------
rs1908815861,2
--30907840(+) GGGGGA/GTAGGA 2 -- us2k10--------
rs1834292521,2
--30908447(+) GGGGTG/TGGGCG 2 -- int10--------

HapMap Linkage Disequilibrium report for CTF1 (30907928 - 30914881 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for CTF1:    About this table    
Variant IDTypeSubtypePubMed ID
dgv35n68CNV Loss17160897
nsv833189CNV Loss17160897
nsv905738CNV Loss21882294
nsv457483CNV Loss19166990
dgv2671n71CNV Loss21882294
nsv905729CNV Loss21882294
nsv905733CNV Loss21882294
nsv905728CNV Loss21882294
dgv2670n71CNV Loss21882294

Human Gene Mutation Database (HGMD): CTF1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CTF1
DNA2.0 Custom Variant and Variant Library Synthesis for CTF1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600435    OMIM disorders: --

4 diseases for CTF1:    
About MalaCards
neonatal stroke    motor neuron disease    acute myocardial infarction    myocardial infarction

1 disease from the University of Copenhagen DISEASES database for CTF1:
Heart disease

Find genes that share disorders with CTF1           About GenesLikeMe

Selected Novoseek inferred disease relationships for CTF1 gene (see all 17)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia 71.5 53 9341130 (2), 12707269 (2), 9304697 (1), 9325015 (1) (see all 48)
hypertrophy 59.9 19 10583628 (1), 10843995 (1), 12234945 (1), 15716706 (1) (see all 17)
heart failure 50.7 23 19155793 (3), 17766177 (2), 11914103 (2), 17885541 (1) (see all 12)
ventricular hypertrophy 42.2 3 15716706 (1), 11113715 (1), 11914103 (1)
cardiac hypertrophy 37.8 3 9602434 (1), 11768733 (1), 15632104 (1)
response acute phase 37.4 1 12773095 (1)
heart failure congestive 34.5 1 12948841 (1), 17637508 (1)
dilated cardiomyopathy 32.2 2 11691527 (1), 11058912 (1)
motor neuron disease 25.2 2 11360260 (2)
valvular heart diseases 22.1 2 14674704 (1), 15721858 (1)

Genetic Association Database (GAD): CTF1
Human Genome Epidemiology (HuGE) Navigator: CTF1 (5 documents)

Export disorders for CTF1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CTF1 gene, integrated from 10 sources (see all 165):
(articles sorted by number of sources associating them with CTF1)
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  1. Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization. (PubMed id 8833032)1, 2, 3, 9 Pennica D.... Wood W.I. (Cytokine 1996)
  2. A novel custom resequencing array for dilated cardiomyopathy. (PubMed id 20474083)1, 4 Zimmerman R.S....Funke B.H. (Genet. Med. 2010)
  3. Protective effect of the 1742(C/G) polymorphism of human cardiotrophin-1 against left ventricular hypertrophy in essential hypertension. (PubMed id 20683337)1, 4 Robador P.A....DA-ez J. (J. Hypertens. 2010)
  4. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Association of plasma cardiotrophin-1 with stage C heart failure in hypertensive patients: potential diagnostic implications. (PubMed id 19155793)1, 9 LA^pez B....DA-ez J. (J. Hypertens. 2009)
  8. Cardiotrophin-1 and TNF-alpha circulating levels at rest and during cardiopulmonary exercise test in athletes and healthy individuals. (PubMed id 20053569)1, 9 Limongelli G....CalabrA^ R. (Cytokine 2010)
  9. Cardiotrophin-1 induces tumor necrosis factor alpha synthesis in human peripheral blood mononuclear cells. (PubMed id 20224758)1, 9 Fritzenwanger M....Figulla H.R. (Mediators Inflamm. 2009)
  10. Cardiotrophin-1 is expressed in adipose tissue and upregulated in the metabolic syndrome. (PubMed id 17940213)1, 9 Natal C....Varo N. (Am. J. Physiol. Endocrinol. Metab. 2008)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1489 HGNC: 2499 AceView: CTF1 Ensembl:ENSG00000150281 euGenes: HUgn1489
ECgene: CTF1 Kegg: 1489 H-InvDB: CTF1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CTF1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CTF1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CTF1 gene:
Search GeneIP for patents involving CTF1

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