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Aliases for CTF1 Gene

Aliases for CTF1 Gene

  • Cardiotrophin 1 2 3
  • CT-1 3 4
  • CT1 3 6
  • Cardiotrophin-1 3
  • Cardiophin 1 3

External Ids for CTF1 Gene

Previous GeneCards Identifiers for CTF1 Gene

  • GC16M9B0154
  • GC16P031404
  • GC16P030904
  • GC16P030943
  • GC16P030815
  • GC16P028471

Summaries for CTF1 Gene

Entrez Gene Summary for CTF1 Gene

  • The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

GeneCards Summary for CTF1 Gene

CTF1 (Cardiotrophin 1) is a Protein Coding gene. Diseases associated with CTF1 include neonatal stroke and motor neuron disease. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and NFAT and Cardiac Hypertrophy. GO annotations related to this gene include cytokine activity and leukemia inhibitory factor receptor binding.

UniProtKB/Swiss-Prot for CTF1 Gene

  • Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTF1 Gene

Genomics for CTF1 Gene

Regulatory Elements for CTF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTF1 Gene

30,896,607 bp from pter
30,903,560 bp from pter
6,954 bases
Plus strand

Genomic View for CTF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTF1 Gene

Proteins for CTF1 Gene

  • Protein details for CTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8MVX4
    • Q5U5Y7

    Protein attributes for CTF1 Gene

    201 amino acids
    Molecular mass:
    21227 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CTF1 Gene


neXtProt entry for CTF1 Gene

Proteomics data for CTF1 Gene at MOPED

Post-translational modifications for CTF1 Gene

No Post-translational modifications

Other Protein References for CTF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CTF1 (Cardiotrophin-1/CT-1)

Protein Products

No data available for DME Specific Peptides for CTF1 Gene

Domains for CTF1 Gene

Protein Domains for CTF1 Gene

Suggested Antigen Peptide Sequences for CTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the IL-6 superfamily.
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with CTF1: view

No data available for Gene Families for CTF1 Gene

Function for CTF1 Gene

Molecular function for CTF1 Gene

GENATLAS Biochemistry:
cardiotrophin 1,21.5kDa,interleukin-6 cytokine family member,expressed in adult human heart,skeletal muscle,ovary,colon,testis,fetal kidney and lung,also expressed in dilated cardiomyopathy
UniProtKB/Swiss-Prot Function:
Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor

Gene Ontology (GO) - Molecular Function for CTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005146 leukemia inhibitory factor receptor binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CTF1: view
genes like me logo Genes that share phenotypes with CTF1: view

Animal Models for CTF1 Gene

MGI Knock Outs for CTF1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CTF1 Gene

Localization for CTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTF1 Gene


Subcellular locations from

Jensen Localization Image for CTF1 Gene COMPARTMENTS Subcellular localization image for CTF1 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 7862649
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with CTF1: view

Pathways for CTF1 Gene

genes like me logo Genes that share pathways with CTF1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • cAMP / Ca2+ Signaling PathwayFinder in human,mouse,rat
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for CTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling TAS 7862649
GO:0007399 nervous system development TAS 7738033
GO:0007517 muscle organ development TAS 7862649
GO:0008283 cell proliferation TAS 7738033
GO:0008284 positive regulation of cell proliferation TAS 7862649
genes like me logo Genes that share ontologies with CTF1: view

Compounds for CTF1 Gene

(2) Novoseek inferred chemical compound relationships for CTF1 Gene

Compound -log(P) Hits PubMed IDs
gp 130 93.6 31
il 11 72.9 1
genes like me logo Genes that share compounds with CTF1: view

Transcripts for CTF1 Gene

Unigene Clusters for CTF1 Gene

Cardiotrophin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTF1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: -

Relevant External Links for CTF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTF1 Gene

mRNA expression in normal human tissues for CTF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CTF1 Gene

This gene is overexpressed in Liver, secretome (19.7), Prostate (13.7), and Uterus (6.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CTF1 Gene

SOURCE GeneReport for Unigene cluster for CTF1 Gene Hs.483811

mRNA Expression by UniProt/SwissProt for CTF1 Gene

Tissue specificity: Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes
genes like me logo Genes that share expressions with CTF1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for CTF1 Gene

Orthologs for CTF1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CTF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CTF1 35
  • 87.73 (n)
  • 82.59 (a)
CTF1 36
  • 82 (a)
(Canis familiaris)
Mammalia CTF1 35
  • 89.55 (n)
  • 84.58 (a)
CTF1 36
  • 85 (a)
(Mus musculus)
Mammalia Ctf1 35
  • 82.26 (n)
  • 79.1 (a)
Ctf1 16
Ctf1 36
  • 79 (a)
(Pan troglodytes)
Mammalia CTF1 35
  • 99.34 (n)
  • 99.5 (a)
CTF1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ctf1 35
  • 82.09 (n)
  • 80.1 (a)
(Monodelphis domestica)
Mammalia CTF1 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia CTF1 36
  • 62 (a)
Species with no ortholog for CTF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CTF1 Gene

Gene Tree for CTF1 (if available)
Gene Tree for CTF1 (if available)

Paralogs for CTF1 Gene

No data available for Paralogs for CTF1 Gene

Variants for CTF1 Gene

Sequence variations from dbSNP and Humsavar for CTF1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1046276 -- 30,903,305(+) TACTC(C/T)GCATC utr-variant-3-prime
rs1870292 -- 30,903,074(-) CCAAG(A/G)AAGGA utr-variant-3-prime
rs2234710 -- 30,896,514(+) AAAAG(A/C/G/T)GGGGG upstream-variant-2KB
rs2234933 Uncertain significance, - 30,902,207(+) ACGCG(A/G)CGGCG missense, reference
rs7185757 -- 30,904,060(+) GAGGT(G/T)CATCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CTF1 Gene

Variant ID Type Subtype PubMed ID
nsv905728 CNV Loss 21882294
nsv905729 CNV Loss 21882294
nsv905733 CNV Loss 21882294
nsv833189 CNV Loss 17160897
dgv35n68 CNV Loss 17160897
dgv2670n71 CNV Loss 21882294
dgv2671n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
nsv905738 CNV Loss 21882294

Relevant External Links for CTF1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTF1 Gene

Disorders for CTF1 Gene

(1) University of Copenhagen DISEASES for CTF1 Gene

(17) Novoseek inferred disease relationships for CTF1 Gene

Disease -log(P) Hits PubMed IDs
leukemia 71.5 50
hypertrophy 59.9 17
heart failure 50.7 16
ventricular hypertrophy 42.2 3
cardiac hypertrophy 37.8 3

Relevant External Links for CTF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CTF1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for CTF1 Gene

Publications for CTF1 Gene

  1. Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization. (PMID: 8833032) Pennica D. … Wood W.I. (Cytokine 1996) 2 3 4 23
  2. Genetic variants in the promoter (g983G>T) and coding region (A92T) of the human cardiotrophin-1 gene (CTF1) in patients with dilated cardiomyopathy. (PMID: 11058912) Erdmann J. … Regitz-Zagrose V. (Hum. Mutat. 2000) 3 23
  3. Augmented expression of cardiotrophin-1 in failing human hearts is accompanied by diminished glycoprotein 130 receptor protein abundance. (PMID: 12234945) Zolk O. … Eschenhagen T. (Circulation 2002) 3 23
  4. Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor. (PMID: 12707269) Plun-Favreau H. … Chabbert M. (J. Biol. Chem. 2003) 3 23
  5. Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system. (PMID: 15219667) Gard A.L. … Pennica D. (Neuroscience 2004) 3 23

Products for CTF1 Gene

Sources for CTF1 Gene

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