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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTDSPL2 Gene

protein-coding   GIFtS: 49
GCID: GC15P044719

CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide...

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small
Phosphatase Like 21 2
     EC 3.1.3.-3
CTDSP-Like 22 3     EC 3.1.38
HSPC1292     EC 3.1.3.168
CTD Small Phosphatase-Like Protein 22     

External Ids:    HGNC: 269361   Entrez Gene: 514962   Ensembl: ENSG000001377707   UniProtKB: Q05D323   

Export aliases for CTDSPL2 gene to outside databases

Previous GC identifers: GC15P042508 GC15P021542


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CTDSPL2 Gene: 
CTDSPL2 (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2) is a protein-coding gene. Diseases associated with CTDSPL2 include sarcoma. GO annotations related to this gene include phosphoprotein phosphatase activity. An important paralog of this gene is CTDSP1.

UniProtKB/Swiss-Prot: CTSL2_HUMAN, Q05D32
Function: Probable phosphatase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTDSPL2 gene promoter:
         Spz1   NF-kappaB   Egr-4   GATA-1   YY1   NF-kappaB2   FOXJ2 (long isoform)   FOXJ2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTDSPL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CTDSPL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTDSPL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3-q21.1   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15.3-q21.1

CTDSPL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTDSPL2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P044719:  view genomic region     (about GC identifiers)

Start:
44,719,432 bp from pter      End:
44,821,236 bp from pter
Size:
101,805 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CTSL2_HUMAN, Q05D32 (See protein sequence)
Recommended Name: CTD small phosphatase-like protein 2  
Size: 466 amino acids; 52999 Da
Sequence caution: Sequence=AAF29030.1; Type=Frameshift; Positions=84, 95; Sequence=AAH18623.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA91664.1; Type=Erroneous
initiation;
Secondary accessions: Q3ZTU1 Q6AI06 Q8IYI9 Q9NVT2 Q9NZX8 Q9P030
Alternative splicing: 2 isoforms:  Q05D32-1   Q05D32-2   

Explore the universe of human proteins at neXtProt for CTDSPL2: NX_Q05D32

Explore proteomics data for CTDSPL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q05D32

  • 4/17 DME Specific Peptides for CTDSPL2 (Q05D32) (see all 17)
     NLITSTP  PPLTAPV  WEVFDPY  FFSPANKN 

    CTDSPL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CTDSPL2 Protein Expression
    REFSEQ proteins: NP_057480.2  
    ENSEMBL proteins: 
     ENSP00000260327   ENSP00000453612   ENSP00000452837   ENSP00000454187   ENSP00000454154  
     ENSP00000453051   ENSP00000453538   ENSP00000380000  

    Human Recombinant Protein Products for CTDSPL2: 
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    Novus Biologicals CTDSPL2 Protein
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    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for CTDSPL2 


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    Cloud-Clone Corp. ELISAs for CTDSPL2 
    Cloud-Clone Corp. CLIAs for CTDSPL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CTD: Serine/threonine phosphatases / CTD aspartate-based phosphatases

    3 InterPro protein domains:
     IPR023214 HAD-like_dom
     IPR011948 Dullard_phosphatase
     IPR004274 NIF

    Graphical View of Domain Structure for InterPro Entry Q05D32

    ProtoNet protein and cluster: Q05D32

    UniProtKB/Swiss-Prot: CTSL2_HUMAN, Q05D32
    Similarity: Belongs to the CTDSPL2 family
    Similarity: Contains 1 FCP1 homology domain


    CTDSPL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTSL2_HUMAN, Q05D32
    Function: Probable phosphatase (By similarity)

         Enzyme Numbers (IUBMB): EC 3.1.32 EC 3.1.3.162 EC 3.1.3.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity IEA--
    GO:0005515protein binding ----
    GO:0016791phosphatase activity ----
         
    CTDSPL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CTDSPL2:
     Decreased focal adhesion (FA)  

         1 MGI phenotypic allele for Ctdspl2 (no phenotypes)

    CTDSPL2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CTDSPL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CTDSPL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTDSPL2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTDSPL2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTDSPL2
    8/114 QIAGEN miScript miRNA Assays for microRNAs that regulate CTDSPL2 (see all 114):
    hsa-miR-3130-5p hsa-miR-548j hsa-miR-4254 hsa-miR-193a-3p hsa-miR-106a hsa-miR-30d hsa-miR-30a hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidCTDSPL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CTDSPL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTDSPL2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CTDSPL2
    Sirion Biotech Customized adenovirus for overexpression of CTDSPL2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: CTDSPL2 (NM_016396)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDSPL2
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                         Customized lentivirus expression plasmids for stable overexpression of CTDSPL2 

    Cell Line
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    Search LifeMap BioReagents cell lines for CTDSPL2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDSPL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CTDSPL2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Phosphatases
    Phosphatases

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CTDSPL2
        Phosphatases



    CTDSPL2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTDSPL2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CTDSPL2 (ENSP000002603274) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTDSPL2 (CTSL2)

    Search CenterWatch for drugs/clinical trials and news about CTDSPL2 / CTSL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CTDSPL2 gene: 
    NM_016396.2  

    Unigene Cluster for CTDSPL2:

    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
    Hs.497967  [show with all ESTs]
    Unigene Representative Sequence: NM_016396
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260327(uc001ztr.3 uc001zts.3 uc001ztt.3) ENST00000558791
    ENST00000560834 ENST00000558966 ENST00000559793 ENST00000558968 ENST00000558373
    ENST00000561189 ENST00000560620 ENST00000559738 ENST00000559175 ENST00000396780(uc010bdv.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTDSPL2
    8/114 QIAGEN miScript miRNA Assays for microRNAs that regulate CTDSPL2 (see all 114):
    hsa-miR-3130-5p hsa-miR-548j hsa-miR-4254 hsa-miR-193a-3p hsa-miR-106a hsa-miR-30d hsa-miR-30a hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidCTDSPL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CTDSPL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTDSPL2
    Clone
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    OriGene clones in human, mouse for CTDSPL2 (see all 7)
    OriGene ORF clones in mouse, rat for CTDSPL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTDSPL2 (NM_016396)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTDSPL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDSPL2
    Sirion Biotech Customized lentivirus for stable overexpression of CTDSPL2 
                         Customized lentivirus expression plasmids for stable overexpression of CTDSPL2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CTDSPL2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTDSPL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTDSPL2

    Additional mRNA sequence: 

    AF161478.1 AF161543.1 AK001385.1 AK128644.1 AK226094.1 AK291230.1 AY364237.1 BC018623.1 
    BC035744.1 CR627421.1 DQ128104.1 

    15 DOTS entries:

    DT.453337  DT.100812895  DT.99938410  DT.40126266  DT.121017700  DT.100812897  DT.102824114  DT.121017777 
    DT.91834702  DT.95375894  DT.100704935  DT.121017716  DT.426450  DT.429964  DT.91644430 

    24/149 AceView cDNA sequences (see all 149):

    CB150530 CD677795 BU155782 BX092212 AA417141 AI458882 AW085183 AA478538 
    BQ435158 W74196 BM667162 CR627421 BM729031 BC035744 AA478539 AA495986 
    BQ951566 BX390094 BE887006 CB146727 BM552151 BM697975 BQ960069 AK128644 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CTDSPL2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c
    SP1:                                            -                             -     -                           
    SP2:                                                                                                            
    SP3:                                                                          -                                 
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for CTDSPL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTDSPL2 expression in normal human tissues (normalized intensities)      CTDSPL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACAGGCTC
    CTDSPL2 Expression
    About this image


    CTDSPL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             fetal cartilage   
     
     Testis (Reproductive System)
             sperm   
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Amnion (Extraembryonic Tissues)
             amniotic fluid   

    See CTDSPL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTDSPL2

    SOURCE GeneReport for Unigene cluster: Hs.497967
        SABiosciences Custom PCR Arrays for CTDSPL2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTDSPL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDSPL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CTDSPL2 gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctdspl21 , 5 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more1, 5 93.76(n)1
    97.42(a)1
      2 (60.46 cM)5
    3295061  NM_212450.31  NP_997615.11 
     1219560015 
    chicken
    (Gallus gallus)
    Aves CTDSPL21 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more 86.27(n)
    93.78(a)
      415574  NM_001012772.1  NP_001012790.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTDSPL26
    Uncharacterized protein
    89(a)
    1 ↔ 1
    GL343795.1(6014-32862)
    African clawed frog
    (Xenopus laevis)
    Amphibia hspc129-prov2 hypothetical protein MGC52903 76.07(n)    BC047962.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb81c122 Transcribed sequence with weak similarity to protein more 78.08(n)    57045692 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0049671 AGAP004967-PA 63.18(n)
    74.09(a)
      1275779  XM_315066.4  XP_315066.4 
    worm
    (Caenorhabditis elegans)
    Secernentea scpl-36
    CTD small phosphatase-like protein 3
    46(a)
    1 ↔ 1
    I(4298259-4302245)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PSR26
    PSR16
    Functionally redundant Psr1p homolog, a plasma mem...
    Plasma membrane associated protein phosphatase inv...
    21(a)
    21(a)
    many ↔ many
    many ↔ many
    XII(180288-181481)
    XII(129330-130613)
    rice
    (Oryza sativa)
    Liliopsida AK101126.12   -- 73.53(n)    AK101126.1 


    ENSEMBL Gene Tree for CTDSPL2 (if available)
    TreeFam Gene Tree for CTDSPL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTDSPL2 gene
    CTDSP12  CTDSPL2  CTDSP22  
    1 SIMAP similar gene for CTDSPL2 using alignment to 6 protein entries:     CTSL2_HUMAN (see all proteins):
    CTDSP1

    CTDSPL2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CTDSPL2
    PGOHUM00000241461 PGOHUM00000241937


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1884 SNPs in CTDSPL2 are shown (see all 1884)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125911781,2
    C,F,H--44717594(+) TTGAGC/ACCAGG 1 -- us2k16Minor allele frequency- A:0.08NS EA NA 658
    rs1378766481,2
    C--44717724(+) GGCCCA/GTAATC 1 -- us2k10--------
    rs1167415681,2
    F--44717739(+) CACTTT/GGGGAG 1 -- us2k11Minor allele frequency- G:0.12WA 118
    rs1437460011,2
    C--44717980(+) TTGTGA/TGTGTG 1 -- us2k10--------
    rs1472065301,2
    C--44718062(+) TTGCAC/TTAGGA 1 -- us2k10--------
    rs1859707091,2
    --44718078(+) TAGGGC/TGCAAA 1 -- us2k10--------
    rs744080781,2
    --44718145(+) CTCCAC/TACTTC 1 -- us2k10--------
    rs1891821511,2
    --44718274(+) CAACAC/GAGTCT 1 -- us2k10--------
    rs1427997681,2
    --44718300(+) CCGTCC/TGTTGT 1 -- us2k10--------
    rs1472812801,2
    --44718368(+) GTTATC/TTTACG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CTDSPL2 (44719432 - 44821236 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CTDSPL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2449630CNV Deletion19546169
    esv2657720CNV Deletion23128226
    nsv904180CNV Loss21882294
    nsv904178CNV Loss21882294
    nsv904177CNV Loss21882294
    nsv904179CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CTDSPL2:    About MalaCards
    sarcoma    


    CTDSPL2 for disorders           About GeneDecksing


    Export disorders for CTDSPL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTDSPL2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with CTDSPL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. CTD small phosphatase like 2 (CTDSPL2) can increase I/- and I^-globin gene expression in K562 cells and CD34+ cells derived from umbi lical cord blood. (PubMed id 20932329)1 Ma Y.N....Zhang J.W. (2010)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    10. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51496 HGNC: 26936 AceView: HSPC129 Ensembl:ENSG00000137770 euGenes: HUgn51496
    ECgene: CTDSPL2 H-InvDB: CTDSPL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTDSPL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CTDSPL2 gene:
    Search GeneIP for patents involving CTDSPL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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