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CTDSPL2 Gene

protein-coding   GIFtS: 50
GCID: GC15P044719

CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small
Phosphatase Like 21 2
     EC 3.1.3.-3
CTDSP-Like 22 3     EC 3.1.38
HSPC1292     EC 3.1.3.168
CTD Small Phosphatase-Like Protein 22     

External Ids:    HGNC: 269361   Entrez Gene: 514962   Ensembl: ENSG000001377707   UniProtKB: Q05D323   

Export aliases for CTDSPL2 gene to outside databases

Previous GC identifers: GC15P042508 GC15P021542


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CTDSPL2 Gene:
CTDSPL2 (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2) is a protein-coding gene. GO annotations related to this gene include phosphoprotein phosphatase activity. An important paralog of this gene is CTDSP1.

UniProtKB/Swiss-Prot: CTSL2_HUMAN, Q05D32
Function: Probable phosphatase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTDSPL2 gene promoter:
         Spz1   NF-kappaB   Egr-4   GATA-1   YY1   NF-kappaB2   FOXJ2 (long isoform)   FOXJ2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTDSPL2 promoter sequence
   Search Chromatin IP Primers for CTDSPL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTDSPL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3-q21.1   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15.3-q21.1

CTDSPL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTDSPL2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P044719:  view genomic region     (about GC identifiers)

Start:
44,719,432 bp from pter      End:
44,821,236 bp from pter
Size:
101,805 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTSL2_HUMAN, Q05D32 (See protein sequence)
Recommended Name: CTD small phosphatase-like protein 2  
Size: 466 amino acids; 52999 Da
Sequence caution: Sequence=AAF29030.1; Type=Frameshift; Positions=84, 95; Sequence=AAH18623.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA91664.1; Type=Erroneous
initiation;
Secondary accessions: Q3ZTU1 Q6AI06 Q8IYI9 Q9NVT2 Q9NZX8 Q9P030
Alternative splicing: 2 isoforms:  Q05D32-1   Q05D32-2   

Explore the universe of human proteins at neXtProt for CTDSPL2: NX_Q05D32

Explore proteomics data for CTDSPL2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys358
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CTDSPL2 (Q05D32) (see all 17)
     NLITSTP  PPLTAPV  WEVFDPY  FFSPANKN 


    See CTDSPL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057480.2  
    ENSEMBL proteins: 
     ENSP00000260327   ENSP00000453612   ENSP00000452837   ENSP00000454187   ENSP00000454154  
     ENSP00000453051   ENSP00000453538   ENSP00000380000  

    CTDSPL2 Human Recombinant Protein Products:

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    OriGene Purified Protein for CTDSPL2
    OriGene Protein Over-expression Lysate for CTDSPL2
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    GenScript Custom Purified and Recombinant Proteins Services for CTDSPL2
    Novus Biologicals CTDSPL2 Protein
    Novus Biologicals CTDSPL2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTDSPL2

     
    Search eBioscience for Proteins for CTDSPL2 

    CTDSPL2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    CTDSPL2 Assay Products:

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    Cloud-Clone Corp. ELISAs for CTDSPL2
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    Search eBioscience for ELISAs for CTDSPL2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CTD: Serine/threonine phosphatases / CTD aspartate-based phosphatases

    3 InterPro protein domains:
     IPR023214 HAD-like_dom
     IPR011948 Dullard_phosphatase
     IPR004274 NIF

    Graphical View of Domain Structure for InterPro Entry Q05D32

    ProtoNet protein and cluster: Q05D32

    UniProtKB/Swiss-Prot: CTSL2_HUMAN, Q05D32
    Similarity: Belongs to the CTDSPL2 family
    Similarity: Contains 1 FCP1 homology domain


    Find genes that share domains with CTDSPL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTSL2_HUMAN, Q05D32
    Function: Probable phosphatase (By similarity)

         Enzyme Numbers (IUBMB): EC 3.1.32 EC 3.1.3.162 EC 3.1.3.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721phosphoprotein phosphatase activity IEA--
    GO:0005515protein binding ----
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with CTDSPL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CTDSPL2:
     Decreased focal adhesion (FA)  

         1 MGI phenotypic allele for Ctdspl2 (no phenotypes)

    Find genes that share phenotypes with CTDSPL2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTDSPL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTDSPL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTDSPL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTDSPL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CTDSPL2:
    hsa-mir-100-5p (MIRT048493), hsa-mir-877-3p (MIRT036890), hsa-mir-132-3p (MIRT021771), hsa-mir-193b-3p (MIRT041362)

    Block miRNA regulation of human, mouse, rat CTDSPL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTDSPL2 (see all 114):
    hsa-miR-3130-5p hsa-miR-548j hsa-miR-4254 hsa-miR-193a-3p hsa-miR-106a hsa-miR-30d hsa-miR-30a hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidCTDSPL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CTDSPL2
    Predesigned siRNA for gene silencing in human, mouse, rat CTDSPL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CTDSPL2

    Clone
    Products:
         
    OriGene clones in human, mouse for CTDSPL2 (see all 7)
    OriGene ORF clones in mouse, rat for CTDSPL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTDSPL2 (NM_016396)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTDSPL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDSPL2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CTDSPL2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CTDSPL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDSPL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTDSPL2 About    
    See pathways by source

    SuperPathContained pathways About
    1Phosphatases
    Phosphatases


    Find genes that share SuperPaths with CTDSPL2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CTDSPL2
        Phosphatases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTDSPL2
    Interactions:

        Search GeneGlobe Interaction Network for CTDSPL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for CTDSPL2 (ENSP000002603274) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAM16ENSP000003156934STRING: ENSP00000315693
    RTF1ENSP000003742804STRING: ENSP00000374280
    POLR1AENSP000002638574STRING: ENSP00000263857
    HAO1ENSP000003680664STRING: ENSP00000368066
    HAO2ENSP000003163394STRING: ENSP00000316339
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTDSPL2 (CTSL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTDSPL2 gene: 
    NM_016396.2  

    Unigene Cluster for CTDSPL2:

    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
    Hs.497967  [show with all ESTs]
    Unigene Representative Sequence: NM_016396
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260327(uc001ztr.3 uc001zts.3 uc001ztt.3) ENST00000558791
    ENST00000560834 ENST00000558966 ENST00000559793 ENST00000558968 ENST00000558373
    ENST00000561189 ENST00000560620 ENST00000559738 ENST00000559175 ENST00000396780(uc010bdv.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CTDSPL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTDSPL2 (see all 114):
    hsa-miR-3130-5p hsa-miR-548j hsa-miR-4254 hsa-miR-193a-3p hsa-miR-106a hsa-miR-30d hsa-miR-30a hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidCTDSPL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CTDSPL2
    Predesigned siRNA for gene silencing in human, mouse, rat CTDSPL2
    Clone
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    OriGene clones in human, mouse for CTDSPL2 (see all 7)
    OriGene ORF clones in mouse, rat for CTDSPL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTDSPL2 (NM_016396)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTDSPL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDSPL2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CTDSPL2
    OriGene qSTAR qPCR primer pairs in human, mouse for CTDSPL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTDSPL2
      QuantiTect SYBR Green Assays in human, mouse, rat CTDSPL2
      QuantiFast Probe-based Assays in human, mouse, rat CTDSPL2

    Additional mRNA sequence: 

    AF161478.1 AF161543.1 AK001385.1 AK128644.1 AK226094.1 AK291230.1 AY364237.1 BC018623.1 
    BC035744.1 CR627421.1 DQ128104.1 

    15 DOTS entries:

    DT.453337  DT.100812895  DT.99938410  DT.40126266  DT.121017700  DT.100812897  DT.102824114  DT.121017777 
    DT.91834702  DT.95375894  DT.100704935  DT.121017716  DT.426450  DT.429964  DT.91644430 

    Selected AceView cDNA sequences (see all 149):

    AL119085 AA478539 BM552151 AW085183 CB150530 BU155782 BQ960069 BM667162 
    AA417141 BE887006 BM457375 AA478538 AW004824 BC035744 BQ951566 BC018623 
    BX092212 BQ229926 AK128644 W79839 AA416987 W74196 BQ435158 CR627421 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CTDSPL2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c
    SP1:                                            -                             -     -                           
    SP2:                                                                                                            
    SP3:                                                                          -                                 
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for CTDSPL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTDSPL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACAGGCTC
    CTDSPL2 Expression
    About this image


    CTDSPL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    CTDSPL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTDSPL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497967
        Custom PCR Arrays for CTDSPL2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CTDSPL2
    OriGene qSTAR qPCR primer pairs in human, mouse for CTDSPL2
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    QuantiFast Probe-based Assays in human, mouse, rat CTDSPL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDSPL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CTDSPL2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctdspl21 , 5 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more1, 5 93.62(n)1
    97.2(a)1
      2 (60.46 cM)5
    3295061  NM_212450.31  NP_997615.11 
     1219560015 
    chicken
    (Gallus gallus)
    Aves CTDSPL21 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more 86.27(n)
    93.78(a)
      415574  NM_001012772.1  NP_001012790.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTDSPL26
    CTD (carboxy-terminal domain, RNA polymerase II, p...
    89(a)
    1 ↔ 1
    GL343795.1(6014-32862)
    African clawed frog
    (Xenopus laevis)
    Amphibia hspc129-prov2 hypothetical protein MGC52903 76.07(n)    BC047962.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb81c122 Transcribed sequence with weak similarity to protein more 78.08(n)    57045692 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0049671 AgaP_AGAP004967 63.18(n)
    74.09(a)
      1275779  XM_315066.4  XP_315066.4 
    worm
    (Caenorhabditis elegans)
    Secernentea scpl-36
    Protein SCPL-3, isoform b (scpl-3) mRNA, complete ...
    46(a)
    1 ↔ 1
    I(4298259-4302245) WBGene00021629
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PSR26
    PSR16
    Functionally redundant Psr1p homolog, a plasma mem...
    Plasma membrane associated protein phosphatase inv...
    26(a)
    23(a)
    many ↔ many
    many ↔ many
    XII(180288-181481) YLR019W
    XII(129330-130613) YLL010C
    rice
    (Oryza sativa)
    Liliopsida AK101126.12   -- 73.53(n)    AK101126.1 


    ENSEMBL Gene Tree for CTDSPL2 (if available)
    TreeFam Gene Tree for CTDSPL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTDSPL2 gene
    CTDSP12  CTDSPL2  CTDSP22  
    1 SIMAP similar gene for CTDSPL2 using alignment to 6 protein entries:     CTSL2_HUMAN (see all proteins):
    CTDSP1

    Find genes that share paralogs with CTDSPL2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CTDSPL2
    PGOHUM00000241461 PGOHUM00000241937


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTDSPL2 (see all 1884)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125911781,2
    C,F,H--44717594(+) TTGAGC/ACCAGG 1 -- us2k16Minor allele frequency- A:0.08NS EA NA 658
    rs1378766481,2
    C--44717724(+) GGCCCA/GTAATC 1 -- us2k10--------
    rs1167415681,2
    F--44717739(+) CACTTT/GGGGAG 1 -- us2k11Minor allele frequency- G:0.12WA 118
    rs1437460011,2
    C--44717980(+) TTGTGA/TGTGTG 1 -- us2k10--------
    rs1472065301,2
    C--44718062(+) TTGCAC/TTAGGA 1 -- us2k10--------
    rs1859707091,2
    --44718078(+) TAGGGC/TGCAAA 1 -- us2k10--------
    rs744080781,2
    --44718145(+) CTCCAC/TACTTC 1 -- us2k10--------
    rs1891821511,2
    --44718274(+) CAACAC/GAGTCT 1 -- us2k10--------
    rs1427997681,2
    --44718300(+) CCGTCC/TGTTGT 1 -- us2k10--------
    rs1472812801,2
    --44718368(+) GTTATC/TTTACG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CTDSPL2 (44719432 - 44821236 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CTDSPL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2449630CNV Deletion19546169
    esv2657720CNV Deletion23128226
    nsv904180CNV Loss21882294
    nsv904178CNV Loss21882294
    nsv904177CNV Loss21882294
    nsv904179CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTDSPL2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with CTDSPL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. CTD small phosphatase like 2 (CTDSPL2) can increase I/- and I^-globin gene expression in K562 cells and CD34+ cells derived from umbilical cord blood. (PubMed id 20932329)1 Ma Y.N....Zhang J.W. (BMC Cell Biol. 2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51496 HGNC: 26936 AceView: HSPC129 Ensembl:ENSG00000137770 euGenes: HUgn51496
    ECgene: CTDSPL2 H-InvDB: CTDSPL2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTDSPL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTDSPL2 gene:
    Search GeneIP for patents involving CTDSPL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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