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Aliases for CTDSPL2 Gene

Aliases for CTDSPL2 Gene

  • CTD Small Phosphatase Like 2 2 3 5
  • CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase Like 2 2 3
  • CTDSP-Like 2 3 4
  • CTD Small Phosphatase-Like Protein 2 3
  • EC 3.1.3.16 61
  • EC 3.1.3.- 4
  • EC 3.1.3 61
  • HSPC058 3
  • HSPC129 3

External Ids for CTDSPL2 Gene

Previous GeneCards Identifiers for CTDSPL2 Gene

  • GC15P042508
  • GC15P044719
  • GC15P021542

Summaries for CTDSPL2 Gene

GeneCards Summary for CTDSPL2 Gene

CTDSPL2 (CTD Small Phosphatase Like 2) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is CTDSPL.

UniProtKB/Swiss-Prot for CTDSPL2 Gene

  • Probable phosphatase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTDSPL2 Gene

Genomics for CTDSPL2 Gene

Regulatory Elements for CTDSPL2 Gene

Enhancers for CTDSPL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F043823 1.2 ENCODE 51.2 -601.2 -601206 5.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CTDSPL2 ENSG00000249839 TUBGCP4 RPS3AP47 MFAP1 ADAL LCMT2 UBR1 ELL3 EIF3J-AS1
GH15F044286 1.1 ENCODE 39.3 -138.4 -138441 3.7 HDGF PKNOX1 CREB3L1 SIN3A FEZF1 DMAP1 YY1 ZNF143 KLF13 SP3 CTDSPL2 ENSG00000259563 LCMT2 TUBGCP4 ENSG00000249839 ELL3 MFAP1 WDR76 ENSG00000259659 ADAL
GH15F044425 1.1 ENCODE 30.4 +0.6 562 3.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A FEZF1 DMAP1 ZNF2 YY1 CTDSPL2 EIF3J-AS1 HNRNPMP1 ENSG00000249839 TP53BP1 MFAP1 ENSG00000259659 CATSPER2P1 GC15P044434
GH15F044705 1.5 FANTOM5 ENCODE 22 +284.2 284234 11.6 HDGF PKNOX1 WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 CBX5 EIF3J-AS1 HNRNPMP1 TRIM69 BLOC1S6 CTDSPL2 B2M MFAP1 PATL2 SPG11 CASC4
GH15F045400 1.1 ENCODE 29 +975.5 975470 3.4 PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 SPATA5L1 CTDSPL2 C15orf48 EIF3J-AS1 HNRNPMP1 BLOC1S6 MIR147B RNU7-5P SQRDL DUOX2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CTDSPL2 on UCSC Golden Path with GeneCards custom track

Promoters for CTDSPL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000407169 566 3601 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for CTDSPL2 Gene

Chromosome:
15
Start:
44,427,234 bp from pter
End:
44,529,038 bp from pter
Size:
101,805 bases
Orientation:
Plus strand

Genomic View for CTDSPL2 Gene

Genes around CTDSPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTDSPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTDSPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTDSPL2 Gene

Proteins for CTDSPL2 Gene

  • Protein details for CTDSPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05D32-CTSL2_HUMAN
    Recommended name:
    CTD small phosphatase-like protein 2
    Protein Accession:
    Q05D32
    Secondary Accessions:
    • Q3ZTU1
    • Q6AI06
    • Q8IYI9
    • Q9NVT2
    • Q9NZX8
    • Q9P030

    Protein attributes for CTDSPL2 Gene

    Size:
    466 amino acids
    Molecular mass:
    52999 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF29030.1; Type=Frameshift; Positions=84, 95; Evidence={ECO:0000305}; Sequence=AAH18623.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91664.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CTDSPL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTDSPL2 Gene

Selected DME Specific Peptides for CTDSPL2 Gene

Q05D32:
  • NGIPIESWF
  • FFSPANKN
  • RKPALPLKTRSTPEFSLVLDLDETLVHCSLNEL
  • NLITSTP
  • VEAEEIVKQL
  • RHRLFREHCVCV
  • YQVYVRLRP
  • LVLDLDETL
  • PPLTAPV
  • SPPRTTLLGTIFSPVF
  • DKNDNELLKL
  • KQNGKLED
  • FIKHVPPLTEEQL
  • RVRRKSQVNGEA
  • KNETGLLSSIKKFIKGSTPKEERENP
  • FTASKKVYA
  • WEVFDPY

Post-translational modifications for CTDSPL2 Gene

  • Ubiquitination at Lys 358
  • Modification sites at PhosphoSitePlus

Domains & Families for CTDSPL2 Gene

Gene Families for CTDSPL2 Gene

Protein Domains for CTDSPL2 Gene

Suggested Antigen Peptide Sequences for CTDSPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05D32

UniProtKB/Swiss-Prot:

CTSL2_HUMAN :
  • Contains 1 FCP1 homology domain.
  • Belongs to the CTDSPL2 family.
Domain:
  • Contains 1 FCP1 homology domain.
Family:
  • Belongs to the CTDSPL2 family.
genes like me logo Genes that share domains with CTDSPL2: view

Function for CTDSPL2 Gene

Molecular function for CTDSPL2 Gene

UniProtKB/Swiss-Prot Function:
Probable phosphatase.

Enzyme Numbers (IUBMB) for CTDSPL2 Gene

Gene Ontology (GO) - Molecular Function for CTDSPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with CTDSPL2: view
genes like me logo Genes that share phenotypes with CTDSPL2: view

Animal Models for CTDSPL2 Gene

MGI Knock Outs for CTDSPL2:

Animal Model Products

  • Taconic Biosciences Mouse Models for CTDSPL2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTDSPL2 Gene

Localization for CTDSPL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTDSPL2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CTDSPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with CTDSPL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CTDSPL2 Gene

Pathways & Interactions for CTDSPL2 Gene

SuperPathways for CTDSPL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTDSPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0030514 negative regulation of BMP signaling pathway IEA --
GO:0046827 positive regulation of protein export from nucleus IEA --
genes like me logo Genes that share ontologies with CTDSPL2: view

No data available for Pathways by source and SIGNOR curated interactions for CTDSPL2 Gene

Transcripts for CTDSPL2 Gene

Unigene Clusters for CTDSPL2 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTDSPL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c
SP1: - - -
SP2:
SP3: -
SP4:

Relevant External Links for CTDSPL2 Gene

GeneLoc Exon Structure for
CTDSPL2
ECgene alternative splicing isoforms for
CTDSPL2

Expression for CTDSPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTDSPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTDSPL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.7), CD8 Tcells (16.0), Blymphocyte (6.7), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTDSPL2 Gene



Protein tissue co-expression partners for CTDSPL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CTDSPL2 Gene:

CTDSPL2

SOURCE GeneReport for Unigene cluster for CTDSPL2 Gene:

Hs.497967
genes like me logo Genes that share expression patterns with CTDSPL2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CTDSPL2 Gene

Orthologs for CTDSPL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTDSPL2 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia CTDSPL2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTDSPL2 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia CTDSPL2 34 35
  • 96.42 (n)
cow
(Bos Taurus)
Mammalia CTDSPL2 34 35
  • 95.64 (n)
oppossum
(Monodelphis domestica)
Mammalia CTDSPL2 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctdspl2 34 16 35
  • 93.62 (n)
rat
(Rattus norvegicus)
Mammalia Ctdspl2 34
  • 93.48 (n)
chicken
(Gallus gallus)
Aves CTDSPL2 34 35
  • 86.27 (n)
lizard
(Anolis carolinensis)
Reptilia CTDSPL2 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctdspl2 34
  • 73.07 (n)
Str.516 34
African clawed frog
(Xenopus laevis)
Amphibia hspc129-prov 34
zebrafish
(Danio rerio)
Actinopterygii ctdspl2b 35
  • 71 (a)
OneToMany
ctdspl2a 34 35
  • 67.61 (n)
BX323045.3 35
  • 40 (a)
OneToMany
wufb81c12 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004967 34
  • 63.18 (n)
worm
(Caenorhabditis elegans)
Secernentea scpl-3 35
  • 46 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSR2 35
  • 26 (a)
ManyToMany
PSR1 35
  • 23 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8447 34
Species where no ortholog for CTDSPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTDSPL2 Gene

ENSEMBL:
Gene Tree for CTDSPL2 (if available)
TreeFam:
Gene Tree for CTDSPL2 (if available)

Paralogs for CTDSPL2 Gene

Paralogs for CTDSPL2 Gene

(1) SIMAP similar genes for CTDSPL2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CTDSPL2 Gene

genes like me logo Genes that share paralogs with CTDSPL2: view

Variants for CTDSPL2 Gene

Sequence variations from dbSNP and Humsavar for CTDSPL2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10467910 -- 44,505,377(+) gtgat(C/T)acgcc intron-variant
rs10467977 -- 44,505,476(+) CACCT(C/G)TAATC intron-variant
rs10518985 -- 44,432,089(-) TTTCC(A/G)AGACA intron-variant
rs10627036 -- 44,516,864(+) GAAAC(-/AG)AGTCT intron-variant
rs10851419 -- 44,428,889(+) TTTTT(A/T)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTDSPL2 Gene

Variant ID Type Subtype PubMed ID
nsv569301 CNV loss 21841781
nsv1127429 CNV deletion 24896259
nsv1122958 CNV deletion 24896259
esv3636309 CNV loss 21293372
esv3636308 CNV loss 21293372
esv2657720 CNV deletion 23128226
esv2449630 CNV deletion 19546169
dgv4510n54 CNV loss 21841781

Variation tolerance for CTDSPL2 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTDSPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTDSPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTDSPL2 Gene

Disorders for CTDSPL2 Gene

Relevant External Links for CTDSPL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTDSPL2

No disorders were found for CTDSPL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTDSPL2 Gene

Publications for CTDSPL2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for CTDSPL2 Gene

Sources for CTDSPL2 Gene

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