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Aliases for CTDSPL2 Gene

Aliases for CTDSPL2 Gene

  • CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase Like 2 2 3
  • CTDSP-Like 2 3 4
  • EC 3.1.3.16 63
  • EC 3.1.3.- 4
  • EC 3.1.3 63
  • HSPC058 3
  • HSPC129 3

External Ids for CTDSPL2 Gene

Previous GeneCards Identifiers for CTDSPL2 Gene

  • GC15P042508
  • GC15P044719
  • GC15P021542

Summaries for CTDSPL2 Gene

GeneCards Summary for CTDSPL2 Gene

CTDSPL2 (CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase Like 2) is a Protein Coding gene. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is CTDSPL.

UniProtKB/Swiss-Prot for CTDSPL2 Gene

  • Probable phosphatase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTDSPL2 Gene

Genomics for CTDSPL2 Gene

Regulatory Elements for CTDSPL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTDSPL2 Gene

Chromosome:
15
Start:
44,427,234 bp from pter
End:
44,529,038 bp from pter
Size:
101,805 bases
Orientation:
Plus strand

Genomic View for CTDSPL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTDSPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTDSPL2 Gene

Proteins for CTDSPL2 Gene

  • Protein details for CTDSPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05D32-CTSL2_HUMAN
    Recommended name:
    CTD small phosphatase-like protein 2
    Protein Accession:
    Q05D32
    Secondary Accessions:
    • Q3ZTU1
    • Q6AI06
    • Q8IYI9
    • Q9NVT2
    • Q9NZX8
    • Q9P030

    Protein attributes for CTDSPL2 Gene

    Size:
    466 amino acids
    Molecular mass:
    52999 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF29030.1; Type=Frameshift; Positions=84, 95; Evidence={ECO:0000305}; Sequence=AAH18623.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA91664.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CTDSPL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTDSPL2 Gene

Proteomics data for CTDSPL2 Gene at MOPED

Post-translational modifications for CTDSPL2 Gene

  • Ubiquitination at Lys 358
  • Modification sites at PhosphoSitePlus

Other Protein References for CTDSPL2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CTDSPL2 (CTDSPL2)

Domains & Families for CTDSPL2 Gene

Gene Families for CTDSPL2 Gene

Protein Domains for CTDSPL2 Gene

Suggested Antigen Peptide Sequences for CTDSPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05D32

UniProtKB/Swiss-Prot:

CTSL2_HUMAN :
  • Contains 1 FCP1 homology domain.
  • Belongs to the CTDSPL2 family.
Domain:
  • Contains 1 FCP1 homology domain.
Family:
  • Belongs to the CTDSPL2 family.
genes like me logo Genes that share domains with CTDSPL2: view

Function for CTDSPL2 Gene

Molecular function for CTDSPL2 Gene

UniProtKB/Swiss-Prot Function:
Probable phosphatase.

Enzyme Numbers (IUBMB) for CTDSPL2 Gene

Gene Ontology (GO) - Molecular Function for CTDSPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IBA --
GO:0005515 protein binding --
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with CTDSPL2: view
genes like me logo Genes that share phenotypes with CTDSPL2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTDSPL2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CTDSPL2 Gene

Localization for CTDSPL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTDSPL2 Gene COMPARTMENTS Subcellular localization image for CTDSPL2 gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for CTDSPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CTDSPL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CTDSPL2 Gene

Pathways & Interactions for CTDSPL2 Gene

SuperPathways for CTDSPL2 Gene

No Data Available

Interacting Proteins for CTDSPL2 Gene

Gene Ontology (GO) - Biological Process for CTDSPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0030514 negative regulation of BMP signaling pathway IEA --
GO:0046827 positive regulation of protein export from nucleus IEA --
genes like me logo Genes that share ontologies with CTDSPL2: view

No data available for Pathways by source and SIGNOR curated interactions for CTDSPL2 Gene

Drugs & Compounds for CTDSPL2 Gene

No Compound Related Data Available

Transcripts for CTDSPL2 Gene

Unigene Clusters for CTDSPL2 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTDSPL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTDSPL2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b · 13c
SP1: - - -
SP2:
SP3: -
SP4:

Relevant External Links for CTDSPL2 Gene

GeneLoc Exon Structure for
CTDSPL2
ECgene alternative splicing isoforms for
CTDSPL2

Expression for CTDSPL2 Gene

mRNA expression in normal human tissues for CTDSPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTDSPL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.7), CD8 Tcells (16.0), Blymphocyte (6.7), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTDSPL2 Gene



SOURCE GeneReport for Unigene cluster for CTDSPL2 Gene Hs.497967

genes like me logo Genes that share expression patterns with CTDSPL2: view

Protein tissue co-expression partners for CTDSPL2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CTDSPL2 Gene

Orthologs for CTDSPL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTDSPL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTDSPL2 35
  • 95.64 (n)
  • 99.36 (a)
CTDSPL2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTDSPL2 35
  • 96.42 (n)
  • 99.36 (a)
CTDSPL2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctdspl2 35
  • 93.62 (n)
  • 97.2 (a)
Ctdspl2 16
Ctdspl2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTDSPL2 35
  • 99.86 (n)
  • 99.79 (a)
CTDSPL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctdspl2 35
  • 93.48 (n)
  • 96.99 (a)
oppossum
(Monodelphis domestica)
Mammalia CTDSPL2 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTDSPL2 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTDSPL2 35
  • 86.27 (n)
  • 93.78 (a)
CTDSPL2 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTDSPL2 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctdspl2 35
  • 73.07 (n)
  • 84.02 (a)
Str.516 35
African clawed frog
(Xenopus laevis)
Amphibia hspc129-prov 35
zebrafish
(Danio rerio)
Actinopterygii ctdspl2a 35
  • 67.61 (n)
  • 75.43 (a)
wufb81c12 35
BX323045.3 36
  • 40 (a)
OneToMany
ctdspl2a 36
  • 73 (a)
OneToMany
ctdspl2b 36
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004967 35
  • 63.18 (n)
  • 74.09 (a)
worm
(Caenorhabditis elegans)
Secernentea scpl-3 36
  • 46 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSR1 36
  • 23 (a)
ManyToMany
PSR2 36
  • 26 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8447 35
Species with no ortholog for CTDSPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTDSPL2 Gene

ENSEMBL:
Gene Tree for CTDSPL2 (if available)
TreeFam:
Gene Tree for CTDSPL2 (if available)

Paralogs for CTDSPL2 Gene

Paralogs for CTDSPL2 Gene

(1) SIMAP similar genes for CTDSPL2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CTDSPL2 Gene

genes like me logo Genes that share paralogs with CTDSPL2: view

Variants for CTDSPL2 Gene

Sequence variations from dbSNP and Humsavar for CTDSPL2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs867816 -- 44,496,090(+) ATTAC(A/G/T)TTTTT intron-variant
rs871923 - 44,496,419(-) CCTCC(A/G)CGTGG reference, missense, nc-transcript-variant
rs883943 -- 44,496,507(-) GTACT(C/T)TCATC intron-variant
rs905303 -- 44,482,195(-) CACCC(A/C)AGCCT intron-variant
rs961163 -- 44,514,450(+) TATAC(C/T)TGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTDSPL2 Gene

Variant ID Type Subtype PubMed ID
nsv904177 CNV Loss 21882294
nsv904178 CNV Loss 21882294
nsv904179 CNV Gain 21882294
esv2657720 CNV Deletion 23128226
nsv904180 CNV Loss 21882294
esv2449630 CNV Deletion 19546169

Variation tolerance for CTDSPL2 Gene

Residual Variation Intolerance Score: 22.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTDSPL2 Gene

HapMap Linkage Disequilibrium report
CTDSPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTDSPL2 Gene

Disorders for CTDSPL2 Gene

Relevant External Links for CTDSPL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTDSPL2
genes like me logo Genes that share disorders with CTDSPL2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTDSPL2 Gene

Publications for CTDSPL2 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  2. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67
  3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 67
  4. CTD small phosphatase like 2 (CTDSPL2) can increase I/- and I^-globin gene expression in K562 cells and CD34+ cells derived from umbilical cord blood. (PMID: 20932329) Ma Y.N. … Zhang J.W. (BMC Cell Biol. 2010) 67
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 67

Products for CTDSPL2 Gene

Sources for CTDSPL2 Gene

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