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Aliases for CTDSPL Gene

Aliases for CTDSPL Gene

  • CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase-Like 2 3
  • Small CTD Phosphatase 3 2 3 4
  • Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 3 3 4
  • RB Protein Serine Phosphatase From Chromosome 3 2 3
  • Nuclear LIM Interactor-Interacting Factor 1 3 4
  • Small C-Terminal Domain Phosphatase 3 3 4
  • NLI-Interacting Factor 1 3 4
  • NIF-Like Protein 3 4
  • EC 3.1.3.16 4 63
  • CTDSP-Like 3 4
  • C3orf8 3 4
  • HYA22 3 4
  • RBSP3 3 4
  • SCP3 3 4
  • Chromosome 3 Open Reading Frame 8 2
  • HYA22 Protein 2
  • Protein YA22 4
  • EC 3.1.3 63
  • PSR1 3
  • NIF1 4
  • NIFL 4
  • YA22 4

External Ids for CTDSPL Gene

Previous HGNC Symbols for CTDSPL Gene

  • C3orf8

Previous GeneCards Identifiers for CTDSPL Gene

  • GC03P037863

Summaries for CTDSPL Gene

GeneCards Summary for CTDSPL Gene

CTDSPL (CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase-Like) is a Protein Coding gene. Among its related pathways are Signaling by BMP and Regulation of cytoplasmic and nuclear SMAD2/3 signaling. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is CTDSP1.

UniProtKB/Swiss-Prot for CTDSPL Gene

  • Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.

Gene Wiki entry for CTDSPL Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTDSPL Gene

Genomics for CTDSPL Gene

Regulatory Elements for CTDSPL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTDSPL Gene

Chromosome:
3
Start:
37,861,960 bp from pter
End:
37,984,469 bp from pter
Size:
122,510 bases
Orientation:
Plus strand

Genomic View for CTDSPL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTDSPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTDSPL Gene

Proteins for CTDSPL Gene

  • Protein details for CTDSPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15194-CTDSL_HUMAN
    Recommended name:
    CTD small phosphatase-like protein
    Protein Accession:
    O15194
    Secondary Accessions:
    • Q3ZTU0
    • Q70KI4
    • Q7Z5Q2

    Protein attributes for CTDSPL Gene

    Size:
    276 amino acids
    Molecular mass:
    31129 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per monomer.;
    Quaternary structure:
    • Interacts with REST (By similarity). Monomer.
    SequenceCaution:
    • Sequence=BAA21667.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CTDSPL Gene

    Alternative splice isoforms for CTDSPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTDSPL Gene

Proteomics data for CTDSPL Gene at MOPED

Selected DME Specific Peptides for CTDSPL Gene

Post-translational modifications for CTDSPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTDSPL Gene

Antibody Products

Domains & Families for CTDSPL Gene

Gene Families for CTDSPL Gene

Protein Domains for CTDSPL Gene

Suggested Antigen Peptide Sequences for CTDSPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15194

UniProtKB/Swiss-Prot:

CTDSL_HUMAN :
  • Contains 1 FCP1 homology domain.
Domain:
  • Contains 1 FCP1 homology domain.
genes like me logo Genes that share domains with CTDSPL: view

Function for CTDSPL Gene

Molecular function for CTDSPL Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.

Enzyme Numbers (IUBMB) for CTDSPL Gene

Gene Ontology (GO) - Molecular Function for CTDSPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
GO:0008420 CTD phosphatase activity IBA --
GO:0016791 phosphatase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CTDSPL: view
genes like me logo Genes that share phenotypes with CTDSPL: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTDSPL

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CTDSPL Gene

Localization for CTDSPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTDSPL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTDSPL Gene COMPARTMENTS Subcellular localization image for CTDSPL gene
Compartment Confidence
extracellular 5
nucleus 3
chloroplast 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTDSPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CTDSPL: view

Pathways & Interactions for CTDSPL Gene

genes like me logo Genes that share pathways with CTDSPL: view

Pathways by source for CTDSPL Gene

Gene Ontology (GO) - Biological Process for CTDSPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006470 protein dephosphorylation IEA --
GO:0008150 biological_process ND --
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with CTDSPL: view

No data available for SIGNOR curated interactions for CTDSPL Gene

Drugs & Compounds for CTDSPL Gene

(1) Drugs for CTDSPL Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Pharma Activator 0

(2) Additional Compounds for CTDSPL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with CTDSPL: view

Transcripts for CTDSPL Gene

Unigene Clusters for CTDSPL Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTDSPL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTDSPL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5:
SP6: - -

Relevant External Links for CTDSPL Gene

GeneLoc Exon Structure for
CTDSPL
ECgene alternative splicing isoforms for
CTDSPL

Expression for CTDSPL Gene

mRNA expression in normal human tissues for CTDSPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTDSPL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (40.9) and Platelet (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTDSPL Gene



SOURCE GeneReport for Unigene cluster for CTDSPL Gene Hs.475963

mRNA Expression by UniProt/SwissProt for CTDSPL Gene

O15194-CTDSL_HUMAN
Tissue specificity: Expression is restricted to non-neuronal tissues.
genes like me logo Genes that share expression patterns with CTDSPL: view

Protein tissue co-expression partners for CTDSPL Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CTDSPL Gene

Orthologs for CTDSPL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTDSPL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTDSPL 35
  • 93.96 (n)
  • 97.46 (a)
CTDSPL 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTDSPL 35
  • 93.92 (n)
  • 98.41 (a)
mouse
(Mus musculus)
Mammalia Ctdspl 35
  • 90.94 (n)
  • 96.38 (a)
Ctdspl 16
Ctdspl 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTDSPL 35
  • 100 (n)
  • 100 (a)
CTDSPL 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTDSPL 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTDSPL 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTDSPL 35
  • 81.7 (n)
  • 89.09 (a)
NFI1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTDSPL 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctdspl 35
  • 75.03 (n)
  • 84.36 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18931 35
zebrafish
(Danio rerio)
Actinopterygii ctdsplb 35
  • 74.49 (n)
  • 80.68 (a)
ctdspla 36
  • 80 (a)
OneToMany
ctdsplb 36
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5830 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scpl-1 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSR1 36
  • 27 (a)
ManyToMany
PSR2 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 76 (a)
OneToMany
Species with no ortholog for CTDSPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTDSPL Gene

ENSEMBL:
Gene Tree for CTDSPL (if available)
TreeFam:
Gene Tree for CTDSPL (if available)

Paralogs for CTDSPL Gene

Paralogs for CTDSPL Gene

(3) SIMAP similar genes for CTDSPL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CTDSPL: view

Variants for CTDSPL Gene

Sequence variations from dbSNP and Humsavar for CTDSPL Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs10095 -- 37,982,062(+) AAAGG(A/G)CCACA utr-variant-3-prime
rs582528 -- 37,895,845(-) gccca(A/C)atctt intron-variant
rs587068 -- 37,895,768(+) AACAG(G/T)AGTTT intron-variant
rs588010 -- 37,863,919(+) TGCCT(A/T)TCAGA intron-variant
rs589662 -- 37,883,149(+) AGAGA(A/C)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTDSPL Gene

Variant ID Type Subtype PubMed ID
nsv834666 CNV Gain+Loss 17160897
dgv1447e1 CNV Complex 17122850
nsv10262 CNV Gain 18304495
dgv1448e1 CNV Complex 17122850
nsv428416 CNV Loss 18775914
nsv522422 CNV Loss 19592680
nsv3767 CNV Loss 18451855
nsv518995 CNV Loss 19592680
nsv437702 CNV Loss 16327808
nsv437329 CNV Loss 16327808
nsv10263 CNV Loss 18304495
esv2676043 CNV Deletion 23128226
esv2725159 CNV Deletion 23290073
esv25990 CNV Loss 19812545
dgv802n67 CNV Loss 20364138
esv2422037 CNV Deletion 20811451
esv32619 CNV Loss 17666407
nsv442857 CNV CNV 18776908
dgv600n27 CNV Loss 19166990
nsv517156 CNV Loss 19592680
nsv522017 CNV Loss 19592680
nsv514147 CNV Loss 21397061

Variation tolerance for CTDSPL Gene

Residual Variation Intolerance Score: 58.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTDSPL Gene

HapMap Linkage Disequilibrium report
CTDSPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTDSPL Gene

Disorders for CTDSPL Gene

Relevant External Links for CTDSPL

Genetic Association Database (GAD)
CTDSPL
Human Genome Epidemiology (HuGE) Navigator
CTDSPL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTDSPL
genes like me logo Genes that share disorders with CTDSPL: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTDSPL Gene

Publications for CTDSPL Gene

  1. An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies. (PMID: 12543795) Protopopov A. … Zabarovsky E.R. (Cancer Res. 2003) 2 23 67
  2. Multimodality imaging of TGFbeta signaling in breast cancer metastases. (PMID: 19325038) Serganova I. … Blasberg R. (FASEB J. 2009) 23 67
  3. High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer. (PMID: 19478941) Kashuba V.I. … Zabarovsky E.R. (PLoS ONE 2009) 23 67
  4. HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro. (PMID: 18725949) Wang F. … Zabarovsky E.R. (PLoS ONE 2008) 23 67
  5. Regulation of Ca2+/calmodulin kinase II by a small C-terminal domain phosphatase. (PMID: 18338982) Gangopadhyay S.S. … Morgan K.G. (Biochem. J. 2008) 23 67

Products for CTDSPL Gene

Sources for CTDSPL Gene

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