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CTDSPL Gene

protein-coding   GIFtS: 60
GCID: GC03P037878

CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide...

(Previous name: chromosome 3 open reading frame 8)
(Previous symbol: C3orf8)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small
Phosphatase-Like1 2
     EC 3.1.3.163 8
C3orf81 2 3     Chromosome 3 Open Reading Frame 81
Small CTD Phosphatase 31 2 3     HYA22 Protein1
RB Protein Serine Phosphatase From Chromosome 31 2     HYA222
Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase
32 3
     PSR12
Nuclear LIM Interactor-Interacting Factor 12 3     CTD Small Phosphatase-Like Protein2
Small C-Terminal Domain Phosphatase 32 3     NIF13
CTDSP-like2 3     NIFL3
RBSP32 3     YA223
SCP32 3     hYA223
NIF-Like Protein2 3     Protein YA223
NLI-Interacting Factor 12 3     EC 3.1.38

External Ids:    HGNC: 168901   Entrez Gene: 102172   Ensembl: ENSG000001446777   OMIM: 6085925   UniProtKB: O151943   

Export aliases for CTDSPL gene to outside databases

Previous GC identifer: GC03P037863


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CTDSPL Gene:
CTDSPL (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like) is a protein-coding gene. GO annotations related to this gene include phosphoprotein phosphatase activity. An important paralog of this gene is CTDSPL2.

UniProtKB/Swiss-Prot: CTDSL_HUMAN, O15194
Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the
C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II
transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation
(By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene
silencing in non-neuronal cells

Gene Wiki entry for CTDSPL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTDSPL gene promoter:
         RP58   HTF   Pax-2   Pax-2a   Meis-1b   Pax-2b   FOXO4   c-Myb   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTDSPL promoter sequence
   Search Chromatin IP Primers for CTDSPL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTDSPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p21.3

CTDSPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTDSPL gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P037878:  view genomic region     (about GC identifiers)

Start:
37,903,451 bp from pter      End:
38,025,960 bp from pter
Size:
122,510 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTDSL_HUMAN, O15194 (See protein sequence)
Recommended Name: CTD small phosphatase-like protein  
Size: 276 amino acids; 31129 Da
Cofactor: Binds 1 magnesium ion per monomer (By similarity)
Subunit: Monomer. Interacts with REST
Sequence caution: Sequence=BAA21667.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CTDSPL:
2HHL (3D)    
Secondary accessions: Q3ZTU0 Q70KI4 Q7Z5Q2
Alternative splicing: 2 isoforms:  O15194-1   O15194-2   

Explore the universe of human proteins at neXtProt for CTDSPL: NX_O15194

Explore proteomics data for CTDSPL at MOPED

Selected DME Specific Peptides for CTDSPL (O15194) (see all 9)
 DNSPASY  NADFIVP  GNYVKDL  DFIVPVEI 


See CTDSPL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001008393.1  NP_005799.2  

ENSEMBL proteins: 
 ENSP00000398288   ENSP00000273179   ENSP00000408183   ENSP00000404977   ENSP00000407443  
 ENSP00000409600  

CTDSPL Human Recombinant Protein Products:

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Novus Biologicals CTDSPL Proteins
Novus Biologicals CTDSPL Lysates
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ProSpec Recombinant Protein for CTDSPL
Cloud-Clone Corp. Proteins for CTDSPL

 
Search eBioscience for Proteins for CTDSPL 

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LSBio Antibodies in human, mouse, rat for CTDSPL

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
CTD: Serine/threonine phosphatases / CTD aspartate-based phosphatases

3 InterPro protein domains:
 IPR023214 HAD-like_dom
 IPR011948 Dullard_phosphatase
 IPR004274 NIF

Graphical View of Domain Structure for InterPro Entry O15194

ProtoNet protein and cluster: O15194

1 Blocks protein domain: IPB004274 NLI interacting factor

UniProtKB/Swiss-Prot: CTDSL_HUMAN, O15194
Similarity: Contains 1 FCP1 homology domain


Find genes that share domains with CTDSPL           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CTDSL_HUMAN, O15194
Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the
C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II
transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation
(By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene
silencing in non-neuronal cells
Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

     Enzyme Numbers (IUBMB): EC 3.1.3.161 2 EC 3.1.32

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0004721phosphoprotein phosphatase activity IEA--
GO:0005515protein binding ----
GO:0016791phosphatase activity ----
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with CTDSPL           About GenesLikeMe


Phenotypes:
     5 GenomeRNAi human phenotypes for CTDSPL:
 Cell division defect  Increased G2M DNA content  Increased mitotic index  Increased number of mitotic ce 
 Synthetic lethal with imatinib 

     1 MGI phenotypic allele for Ctdspl (no phenotypes)

Find genes that share phenotypes with CTDSPL           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTDSPL
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTDSPL

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTDSPL
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTDSPL

miRNA
Products:
    
miRTarBase miRNAs that target CTDSPL:
hsa-mir-124-3p (MIRT022910), hsa-mir-183-5p (MIRT025030), hsa-mir-18a-5p (MIRT031350)

Block miRNA regulation of human, mouse, rat CTDSPL using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CTDSPL (see all 121):
hsa-miR-3678-3p hsa-miR-579 hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-578 hsa-miR-3653
SwitchGear 3'UTR luciferase reporter plasmidCTDSPL 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CTDSPL
Predesigned siRNA for gene silencing in human, mouse, rat CTDSPL

Gene Editing
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTDSPL
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDSPL

Cell Line
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GenScript Custom overexpressing Cell Line Services for CTDSPL
Browse ESI BIO Cell Lines and PureStem Progenitors for CTDSPL 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDSPL


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CTDSL_HUMAN, O15194: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
extracellular1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ----
GO:0005634nucleus IEA--
GO:0070062extracellular vesicular exosome IDA19056867

Find genes that share ontologies with CTDSPL           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CTDSPL About    
See pathways by source

SuperPathContained pathways About
1Signaling by BMP
BMP receptor signaling0.31
2Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Regulation of cytoplasmic and nuclear SMAD2/3 signaling


2 BioSystems Pathways for CTDSPL
    BMP receptor signaling
Regulation of cytoplasmic and nuclear SMAD2/3 signaling


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTDSPL
Interactions:

    Search GeneGlobe Interaction Network for CTDSPL

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CTDSPL (O151943 ENSP000002731794) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
InteractantInteraction Details
GeneCardExternal ID(s)
CDK9P507503, ENSP000003623614I2D: score=2 STRING: ENSP00000362361
SNAI1O958633, ENSP000002440504I2D: score=2 STRING: ENSP00000244050
SMAD2ENSP000002621604STRING: ENSP00000262160
POLR1AENSP000002638574STRING: ENSP00000263857
UBCENSP000003448184STRING: ENSP00000344818
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--

Find genes that share ontologies with CTDSPL           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CTDSPL (CTDSL)

1 Novoseek inferred chemical compound relationship for CTDSPL gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
atp 9.91 1 9560416 (1)



Find genes that share compounds with CTDSPL           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CTDSPL gene (2 alternative transcripts): 
NM_001008392.1  NM_005808.2  

Unigene Cluster for CTDSPL:

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
Hs.475963  [show with all ESTs]
Unigene Representative Sequence: D88153
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000443503(uc003chh.3) ENST00000273179(uc003chg.3) ENST00000435525
ENST00000486978 ENST00000310189 ENST00000416688 ENST00000447745 ENST00000436654

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CTDSPL using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate CTDSPL (see all 121):
hsa-miR-3678-3p hsa-miR-579 hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-578 hsa-miR-3653
SwitchGear 3'UTR luciferase reporter plasmidCTDSPL 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CTDSPL
Predesigned siRNA for gene silencing in human, mouse, rat CTDSPL
Clone
Products:
     
OriGene clones in human, mouse for CTDSPL (see all 11)
OriGene ORF clones in mouse, rat for CTDSPL
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): CTDSPL (NM_005808)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTDSPL
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDSPL
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CTDSPL
OriGene qSTAR qPCR primer pairs in human, mouse for CTDSPL
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTDSPL
  QuantiTect SYBR Green Assays in human, mouse, rat CTDSPL
  QuantiFast Probe-based Assays in human, mouse, rat CTDSPL

Additional mRNA sequence: 

AJ575644.1 AJ575645.1 AY279532.1 AY364238.1 D88153.1 

13 DOTS entries:

DT.40111211  DT.100795972  DT.95209056  DT.454957  DT.95209068  DT.95209057  DT.95209049  DT.100795971 
DT.87078915  DT.91773812  DT.120860716  DT.95336707  DT.120860867 

Selected AceView cDNA sequences (see all 357):

AW297534 AI971825 AA421118 AI014464 BQ026609 AI768308 AA664401 Z44840 
BM478840 BP340299 AI800219 BU689808 BI712061 BQ425314 AI401817 AY279532 
AI352325 BM449987 AA703367 BQ181940 BM746160 BI912471 AW275051 AI760260 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CTDSPL (see all 6)    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14
SP1:                    -     -                                   -                                                         
SP2:                                                              -                             -     -     -               
SP3:                    -     -     -                             -                                                         
SP4:                                -                             -                                                         
SP5:                                                                                                                        


ECgene alternative splicing isoforms for CTDSPL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CTDSPL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGAAACTGCA
CTDSPL Expression
About this image


CTDSPL expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Blood (Hematopoietic System)
         Megakaryocytes Hematopoietic Bone Marrow
CTDSPL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CTDSPL Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.475963

UniProtKB/Swiss-Prot: CTDSL_HUMAN, O15194
Tissue specificity: Expression is restricted to non-neuronal tissues

    Custom PCR Arrays for CTDSPL
Primer
Products:
OriGene qPCR primer pairs and template standards for CTDSPL
OriGene qSTAR qPCR primer pairs in human, mouse for CTDSPL
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CTDSPL
QuantiTect SYBR Green Assays in human, mouse, rat CTDSPL
QuantiFast Probe-based Assays in human, mouse, rat CTDSPL
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDSPL

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for CTDSPL gene from Selected species (see all 16)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ctdspl1 , 5 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more1, 5 90.94(n)1
96.38(a)1
  9 (71.07 cM)5
692741  NM_133710.31  NP_598471.31 
 1189264535 
chicken
(Gallus gallus)
Aves CTDSPL1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more 81.7(n)
89.09(a)
  408252  NM_001001316.1  NP_001001316.1 
lizard
(Anolis carolinensis)
Reptilia CTDSPL6
CTD (carboxy-terminal domain, RNA polymerase II, p...
89(a)
1 ↔ 1
6(1195251-1218650)
African clawed frog
(Xenopus laevis)
Amphibia Xl.189312 Xenopus laevis NIF (NIF) mRNA, complete cds 81.32(n)    AY280863.1 
zebrafish
(Danio rerio)
Actinopterygii CK361160.12   -- 78.76(n)    CK361160.1 
fruit fly
(Drosophila melanogaster)
Insecta CG58306
--
47(a)
1 → many
3L(15985753-15997836)
worm
(Caenorhabditis elegans)
Secernentea scpl-16
Protein SCPL-1, isoform b
30(a)
1 → many
I(10085713-10102012) WBGene00007054
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSR26
PSR16
Functionally redundant Psr1p homolog, a plasma mem...
Plasma membrane associated protein phosphatase inv...
29(a)
27(a)
many ↔ many
many ↔ many
XII(180288-181481) YLR019W
XII(129330-130613) YLL010C


ENSEMBL Gene Tree for CTDSPL (if available)
TreeFam Gene Tree for CTDSPL (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CTDSPL gene
CTDSPL22  CTDSP12  CTDSP22  
3 SIMAP similar genes for CTDSPL using alignment to 5 protein entries:     CTDSL_HUMAN (see all proteins):
CTDSP2    CTDSP1    CTDNEP1

Find genes that share paralogs with CTDSPL           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CTDSPL (see all 2294)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs754369311,2
C,F--37901730(+) CTCCTA/TCAGGT 2 -- us2k11Minor allele frequency- T:0.04WA 118
rs1124541401,2
C--37901756(+) TCTGCG/-GGGCT 2 -- us2k11Minor allele frequency- -:0.50CSA 2
rs1896782521,2
C--37901922(+) CCACAC/GAAGAG 2 -- us2k10--------
rs1835310211,2
--37901934(+) TGGACA/CTGCCC 2 -- us2k10--------
rs622415481,2
C,F--37901957(+) GTGCGC/TGCGCA 2 -- us2k13Minor allele frequency- T:0.08NA WA 240
rs1878750131,2
--37902105(+) AGCCCG/TCCCTC 2 -- us2k10--------
rs1907389071,2
--37902106(+) GCCCGC/TCCTCC 2 -- us2k10--------
rs1386831971,2
C--37902184(+) ACGCGA/GGCGTC 2 -- us2k10--------
rs1426891231,2
--37902226(+) CACTTG/TGTCGT 2 -- us2k10--------
rs6886031,2
C,H--37902395(+) ACTGCC/TCAGGC 2 -- us2k16Minor allele frequency- T:0.00NS EA NA 366

HapMap Linkage Disequilibrium report for CTDSPL (37903451 - 38025960 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CTDSPL (see all 22):    About this table    
Variant IDTypeSubtypePubMed ID
esv2676043CNV Deletion23128226
esv2725159CNV Deletion23290073
esv2422037CNV Deletion20811451
nsv428416CNV Loss18775914
nsv514147CNV Loss21397061
dgv802n67CNV Loss20364138
nsv437329CNV Loss16327808
nsv517156CNV Loss19592680
nsv437702CNV Loss16327808
nsv522422CNV Loss19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608592    OMIM disorders: --


Find genes that share disorders with CTDSPL           About GenesLikeMe

Genetic Association Database (GAD): CTDSPL
Human Genome Epidemiology (HuGE) Navigator: CTDSPL (3 documents)

Export disorders for CTDSPL gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CTDSPL gene, integrated from 10 sources (see all 42):
(articles sorted by number of sources associating them with CTDSPL)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line. (PubMed id 9179494)1, 2, 3 Ishikawa S.... Nakamura Y. (DNA Res. 1997)
  2. An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies. (PubMed id 12543795)1, 3, 9 Protopopov A.... Zabarovsky E.R. (Cancer Res. 2003)
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  4. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PubMed id 19047128)1, 4 Horikawa Y....Wu X. (Clin. Cancer Res. 2008)
  5. A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study. (PubMed id 17903305)1, 4 Murabito J.M....Hwang S.J. (BMC Med. Genet. 2007)
  6. RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies. (PubMed id 15051889)1, 2 Kashuba V.I....Zabarovsky E.R. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  7. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. (PubMed id 12721286)1, 2 Yeo M.... Gill G.N. (J. Biol. Chem. 2003)
  8. High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer. (PubMed id 19478941)1, 9 Kashuba V.I....Zabarovsky E.R. (PLoS ONE 2009)
  9. MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia. (PubMed id 21643017)1 Zheng Y.S....Chen Y.Q. (Oncogene 2012)
  10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10217 HGNC: 16890 AceView: CTDSPL Ensembl:ENSG00000144677 euGenes: HUgn10217
ECgene: CTDSPL H-InvDB: CTDSPL

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CTDSPL Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CTDSPL Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CTDSPL gene:
Search GeneIP for patents involving CTDSPL

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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