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Aliases for CTDSPL Gene

Aliases for CTDSPL Gene

  • CTD Small Phosphatase Like 2 3 5
  • Small CTD Phosphatase 3 2 3 4
  • CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase-Like 2 3
  • Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 3 3 4
  • RB Protein Serine Phosphatase From Chromosome 3 2 3
  • Nuclear LIM Interactor-Interacting Factor 1 3 4
  • Small C-Terminal Domain Phosphatase 3 3 4
  • NLI-Interacting Factor 1 3 4
  • NIF-Like Protein 3 4
  • EC 3.1.3.16 4 61
  • CTDSP-Like 3 4
  • C3orf8 3 4
  • HYA22 3 4
  • RBSP3 3 4
  • SCP3 3 4
  • CTD Small Phosphatase-Like Protein 3
  • Chromosome 3 Open Reading Frame 8 2
  • HYA22 Protein 2
  • Protein YA22 4
  • EC 3.1.3 61
  • PSR1 3
  • NIF1 4
  • NIFL 4
  • YA22 4

External Ids for CTDSPL Gene

Previous HGNC Symbols for CTDSPL Gene

  • C3orf8

Previous GeneCards Identifiers for CTDSPL Gene

  • GC03P037863

Summaries for CTDSPL Gene

GeneCards Summary for CTDSPL Gene

CTDSPL (CTD Small Phosphatase Like) is a Protein Coding gene. Among its related pathways are Regulation of cytoplasmic and nuclear SMAD2/3 signaling and Signaling by BMP. GO annotations related to this gene include phosphatase activity and phosphoprotein phosphatase activity. An important paralog of this gene is CTDSP1.

UniProtKB/Swiss-Prot for CTDSPL Gene

  • Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.

Gene Wiki entry for CTDSPL Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTDSPL Gene

Genomics for CTDSPL Gene

Regulatory Elements for CTDSPL Gene

Enhancers for CTDSPL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CTDSPL on UCSC Golden Path with GeneCards custom track

Promoters for CTDSPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CTDSPL Gene

Chromosome:
3
Start:
37,861,960 bp from pter
End:
37,984,469 bp from pter
Size:
122,510 bases
Orientation:
Plus strand

Genomic View for CTDSPL Gene

Genes around CTDSPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTDSPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTDSPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTDSPL Gene

Proteins for CTDSPL Gene

  • Protein details for CTDSPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15194-CTDSL_HUMAN
    Recommended name:
    CTD small phosphatase-like protein
    Protein Accession:
    O15194
    Secondary Accessions:
    • Q3ZTU0
    • Q70KI4
    • Q7Z5Q2

    Protein attributes for CTDSPL Gene

    Size:
    276 amino acids
    Molecular mass:
    31129 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with REST (By similarity). Monomer.
    SequenceCaution:
    • Sequence=BAA21667.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CTDSPL Gene

    Alternative splice isoforms for CTDSPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTDSPL Gene

Selected DME Specific Peptides for CTDSPL Gene

Post-translational modifications for CTDSPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTDSPL Gene

Domains & Families for CTDSPL Gene

Gene Families for CTDSPL Gene

Protein Domains for CTDSPL Gene

Suggested Antigen Peptide Sequences for CTDSPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15194

UniProtKB/Swiss-Prot:

CTDSL_HUMAN :
  • Contains 1 FCP1 homology domain.
Domain:
  • Contains 1 FCP1 homology domain.
genes like me logo Genes that share domains with CTDSPL: view

Function for CTDSPL Gene

Molecular function for CTDSPL Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.

Enzyme Numbers (IUBMB) for CTDSPL Gene

Gene Ontology (GO) - Molecular Function for CTDSPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004721 phosphoprotein phosphatase activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CTDSPL: view
genes like me logo Genes that share phenotypes with CTDSPL: view

Animal Models for CTDSPL Gene

MGI Knock Outs for CTDSPL:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTDSPL Gene

Localization for CTDSPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTDSPL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTDSPL Gene COMPARTMENTS Subcellular localization image for CTDSPL gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
chloroplast 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CTDSPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CTDSPL: view

Pathways & Interactions for CTDSPL Gene

genes like me logo Genes that share pathways with CTDSPL: view

Pathways by source for CTDSPL Gene

Gene Ontology (GO) - Biological Process for CTDSPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006470 protein dephosphorylation IEA --
GO:0008150 biological_process ND --
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA --
genes like me logo Genes that share ontologies with CTDSPL: view

No data available for SIGNOR curated interactions for CTDSPL Gene

Drugs & Compounds for CTDSPL Gene

(3) Drugs for CTDSPL Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with CTDSPL: view

Transcripts for CTDSPL Gene

Unigene Clusters for CTDSPL Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTDSPL Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5:
SP6: - -

Relevant External Links for CTDSPL Gene

GeneLoc Exon Structure for
CTDSPL
ECgene alternative splicing isoforms for
CTDSPL

Expression for CTDSPL Gene

mRNA expression in normal human tissues for CTDSPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTDSPL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (40.9) and Platelet (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTDSPL Gene



Protein tissue co-expression partners for CTDSPL Gene

NURSA nuclear receptor signaling pathways regulating expression of CTDSPL Gene:

CTDSPL

SOURCE GeneReport for Unigene cluster for CTDSPL Gene:

Hs.475963

mRNA Expression by UniProt/SwissProt for CTDSPL Gene:

O15194-CTDSL_HUMAN
Tissue specificity: Expression is restricted to non-neuronal tissues.
genes like me logo Genes that share expression patterns with CTDSPL: view

Primer Products

No data available for mRNA differential expression in normal tissues for CTDSPL Gene

Orthologs for CTDSPL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTDSPL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTDSPL 34
  • 93.96 (n)
  • 97.46 (a)
CTDSPL 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTDSPL 34
  • 93.92 (n)
  • 98.41 (a)
mouse
(Mus musculus)
Mammalia Ctdspl 34
  • 90.94 (n)
  • 96.38 (a)
Ctdspl 16
Ctdspl 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTDSPL 34
  • 100 (n)
  • 100 (a)
CTDSPL 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTDSPL 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTDSPL 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTDSPL 34
  • 81.7 (n)
  • 89.09 (a)
NFI1 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTDSPL 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctdspl 34
  • 75.03 (n)
  • 84.36 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18931 34
zebrafish
(Danio rerio)
Actinopterygii ctdsplb 34
  • 74.49 (n)
  • 80.68 (a)
ctdspla 35
  • 80 (a)
OneToMany
ctdsplb 35
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5830 35
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scpl-1 35
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSR1 35
  • 27 (a)
ManyToMany
PSR2 35
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 76 (a)
OneToMany
Species where no ortholog for CTDSPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTDSPL Gene

ENSEMBL:
Gene Tree for CTDSPL (if available)
TreeFam:
Gene Tree for CTDSPL (if available)

Paralogs for CTDSPL Gene

Paralogs for CTDSPL Gene

(3) SIMAP similar genes for CTDSPL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CTDSPL: view

Variants for CTDSPL Gene

Sequence variations from dbSNP and Humsavar for CTDSPL Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_019683 -
VAR_019684 -
VAR_019685 -
rs10095 -- 37,982,062(+) AAAGG(A/G)CCACA utr-variant-3-prime
rs993615 -- 37,957,554(+) ACTGG(C/G)CTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTDSPL Gene

Variant ID Type Subtype PubMed ID
dgv1368e212 CNV loss 25503493
dgv1369e212 CNV loss 25503493
dgv2510n106 CNV deletion 24896259
dgv4721n100 CNV loss 25217958
dgv600n27 CNV loss 19166990
dgv802n67 CNV loss 20364138
dgv8282n54 CNV loss 21841781
dgv8283n54 CNV loss 21841781
dgv8284n54 CNV loss 21841781
dgv8285n54 CNV loss 21841781
dgv8286n54 CNV loss 21841781
esv2422037 CNV deletion 20811451
esv25990 CNV loss 19812545
esv2676043 CNV deletion 23128226
esv2725159 CNV deletion 23290073
esv2759140 CNV loss 17122850
esv2760795 CNV loss 21179565
esv2763754 CNV loss 21179565
esv32619 CNV loss 17666407
esv3561753 CNV deletion 23714750
esv3561754 CNV deletion 23714750
esv3584784 CNV loss 24956385
esv3595887 CNV gain 21293372
esv3595895 CNV gain 21293372
esv3595902 CNV loss 21293372
esv3595903 CNV loss 21293372
esv3595904 CNV loss 21293372
esv3893682 CNV loss 25118596
esv3893683 CNV loss 25118596
nsv10262 CNV gain 18304495
nsv10263 CNV loss 18304495
nsv1072682 CNV deletion 25765185
nsv1160928 CNV duplication 26073780
nsv1160929 OTHER complex 26073780
nsv1160930 CNV deletion 26073780
nsv3767 CNV deletion 18451855
nsv428416 CNV loss 18775914
nsv437329 CNV loss 16327808
nsv437702 CNV loss 16327808
nsv442857 CNV loss 18776908
nsv514147 CNV loss 21397061
nsv517156 CNV loss 19592680
nsv518995 CNV loss 19592680
nsv522017 CNV loss 19592680
nsv522422 CNV loss 19592680
nsv590076 CNV loss 21841781
nsv590077 CNV loss 21841781
nsv590078 CNV loss 21841781
nsv590094 CNV loss 21841781
nsv590100 CNV loss 21841781
nsv834666 CNV gain+loss 17160897
nsv954464 CNV deletion 24416366
nsv980087 CNV deletion 23825009

Variation tolerance for CTDSPL Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTDSPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTDSPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTDSPL Gene

Disorders for CTDSPL Gene

Relevant External Links for CTDSPL

Genetic Association Database (GAD)
CTDSPL
Human Genome Epidemiology (HuGE) Navigator
CTDSPL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTDSPL

No disorders were found for CTDSPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTDSPL Gene

Publications for CTDSPL Gene

  1. An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies. (PMID: 12543795) Protopopov A. … Zabarovsky E.R. (Cancer Res. 2003) 2 3 22 65
  2. Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line. (PMID: 9179494) Ishikawa S. … Nakamura Y. (DNA Res. 1997) 2 3 4 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer. (PMID: 19478941) Kashuba V.I. … Zabarovsky E.R. (PLoS ONE 2009) 3 22 65
  5. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PMID: 19047128) Horikawa Y. … Wu X. (Clin. Cancer Res. 2008) 3 46 65

Products for CTDSPL Gene

Sources for CTDSPL Gene

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