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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTDSPL Gene

protein-coding   GIFtS: 60
GCID: GC03P037878

CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide...

(Previous name: chromosome 3 open reading frame 8)
(Previous symbol: C3orf8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small
Phosphatase-Like1 2
     EC 3.1.3.163 8
C3orf81 2 3     Chromosome 3 Open Reading Frame 81
Small CTD Phosphatase 31 2 3     HYA22 Protein1
RB Protein Serine Phosphatase From Chromosome 31 2     HYA222
Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase
32 3
     PSR12
Nuclear LIM Interactor-Interacting Factor 12 3     CTD Small Phosphatase-Like Protein2
Small C-Terminal Domain Phosphatase 32 3     NIF13
CTDSP-like2 3     NIFL3
RBSP32 3     YA223
SCP32 3     hYA223
NIF-Like Protein2 3     Protein YA223
NLI-Interacting Factor 12 3     EC 3.1.38

External Ids:    HGNC: 168901   Entrez Gene: 102172   Ensembl: ENSG000001446777   OMIM: 6085925   UniProtKB: O151943   

Export aliases for CTDSPL gene to outside databases

Previous GC identifer: GC03P037863


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CTDSPL Gene: 
CTDSPL (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like) is a protein-coding gene. Diseases associated with CTDSPL include pandas, and azoospermia, and among its related super-pathways are Signaling by BMP. GO annotations related to this gene include phosphoprotein phosphatase activity and molecular_function. An important paralog of this gene is CTDSPL2.

UniProtKB/Swiss-Prot: CTDSL_HUMAN, O15194
Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the
C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II
transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation
(By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene
silencing in non-neuronal cells

Gene Wiki entry for CTDSPL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTDSPL gene promoter:
         RP58   HTF   Pax-2   Pax-2a   Meis-1b   Pax-2b   FOXO4   c-Myb   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTDSPL promoter sequence
   Search SABiosciences Chromatin IP Primers for CTDSPL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTDSPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p21.3

CTDSPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTDSPL gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P037878:  view genomic region     (about GC identifiers)

Start:
37,903,451 bp from pter      End:
38,025,960 bp from pter
Size:
122,510 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CTDSL_HUMAN, O15194 (See protein sequence)
Recommended Name: CTD small phosphatase-like protein  
Size: 276 amino acids; 31129 Da
Cofactor: Binds 1 magnesium ion per monomer (By similarity)
Subunit: Monomer. Interacts with REST
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAA21667.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CTDSPL:
2HHL (3D)    
Secondary accessions: Q3ZTU0 Q70KI4 Q7Z5Q2
Alternative splicing: 2 isoforms:  O15194-1   O15194-2   

Explore the universe of human proteins at neXtProt for CTDSPL: NX_O15194

Explore proteomics data for CTDSPL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15194

  • 4/9 DME Specific Peptides for CTDSPL (O15194) (see all 9)
     DNSPASY  NADFIVP  GNYVKDL  DFIVPVEI 

    CTDSPL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CTDSPL Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001008393.1  NP_005799.2  

    ENSEMBL proteins: 
     ENSP00000398288   ENSP00000273179   ENSP00000408183   ENSP00000404977   ENSP00000407443  
     ENSP00000409600  

    Human Recombinant Protein Products for CTDSPL: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CTDSPL
    Cloud-Clone Corp. Proteins for CTDSPL 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--

    CTDSPL for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CTD: Serine/threonine phosphatases / CTD aspartate-based phosphatases

    3 InterPro protein domains:
     IPR023214 HAD-like_dom
     IPR011948 Dullard_phosphatase
     IPR004274 NIF

    Graphical View of Domain Structure for InterPro Entry O15194

    ProtoNet protein and cluster: O15194

    1 Blocks protein domain: IPB004274 NLI interacting factor

    UniProtKB/Swiss-Prot: CTDSL_HUMAN, O15194
    Similarity: Contains 1 FCP1 homology domain


    CTDSPL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTDSL_HUMAN, O15194
    Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the
    C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II
    transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation
    (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene
    silencing in non-neuronal cells
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 2 EC 3.1.32

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0004721phosphoprotein phosphatase activity IEA--
    GO:0005515protein binding ----
    GO:0016791phosphatase activity ----
    GO:0046872metal ion binding IEA--
         
    CTDSPL for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for CTDSPL:
     Cell division defect  Increased G2M DNA content  Increased mitotic index  Increased number of mitotic ce 
     Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CTDSPL 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTDSPL 
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    SwitchGear 3'UTR luciferase reporter plasmidCTDSPL 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CTDSPL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by BMP
    BMP receptor signaling0.31
    2Regulation of cytoplasmic and nuclear SMAD2/3 signaling
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling


    2 BioSystems Pathways for CTDSPL
        Regulation of cytoplasmic and nuclear SMAD2/3 signaling
    BMP receptor signaling


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTDSPL

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for CTDSPL (O151943 ENSP000002731794) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK9P507503, ENSP000003623614I2D: score=2 STRING: ENSP00000362361
    SNAI1O958633, ENSP000002440504I2D: score=2 STRING: ENSP00000244050
    SMAD2ENSP000002621604STRING: ENSP00000262160
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    CTDSPL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CTDSPL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTDSPL (CTDSL)

    1 Novoseek inferred chemical compound relationship for CTDSPL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 9.91 1 9560416 (1)

    Search CenterWatch for drugs/clinical trials and news about CTDSPL / CTDSL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CTDSPL gene (2 alternative transcripts): 
    NM_001008392.1  NM_005808.2  

    Unigene Cluster for CTDSPL:

    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
    Hs.475963  [show with all ESTs]
    Unigene Representative Sequence: D88153
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000443503(uc003chh.3) ENST00000273179(uc003chg.3) ENST00000435525
    ENST00000486978 ENST00000310189 ENST00000416688 ENST00000447745 ENST00000436654

    miRNA
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    8/121 QIAGEN miScript miRNA Assays for microRNAs that regulate CTDSPL (see all 121):
    hsa-miR-3678-3p hsa-miR-579 hsa-miR-520e hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-578 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidCTDSPL 3' UTR sequence
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    Additional mRNA sequence: 

    AJ575644.1 AJ575645.1 AY279532.1 AY364238.1 D88153.1 

    13 DOTS entries:

    DT.40111211  DT.100795972  DT.95209056  DT.454957  DT.95209068  DT.95209057  DT.95209049  DT.100795971 
    DT.87078915  DT.91773812  DT.120860716  DT.95336707  DT.120860867 

    24/357 AceView cDNA sequences (see all 357):

    BM478840 AI014464 AA421118 AW297534 AI971825 Z44840 AA664401 BQ026609 
    BP340299 AI800219 BU689808 BI712061 BQ425314 AI401817 AY279532 AI352325 
    BM449987 AA703367 BQ181940 BM746160 BI912471 AW275051 AI760260 AA133915 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CTDSPL (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14
    SP1:                    -     -                                   -                                                         
    SP2:                                                              -                             -     -     -               
    SP3:                    -     -     -                             -                                                         
    SP4:                                -                             -                                                         
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for CTDSPL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTDSPL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAACTGCA
    CTDSPL Expression
    About this image


    See CTDSPL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTDSPL

    SOURCE GeneReport for Unigene cluster: Hs.475963

    UniProtKB/Swiss-Prot: CTDSL_HUMAN, O15194
    Tissue specificity: Expression is restricted to non-neuronal tissues

        SABiosciences Custom PCR Arrays for CTDSPL
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CTDSPL gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctdspl1 , 5 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more1, 5 90.94(n)1
    96.38(a)1
      9 (71.07 cM)5
    692741  NM_133710.31  NP_598471.31 
     1189264535 
    chicken
    (Gallus gallus)
    Aves CTDSPL1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more 81.7(n)
    89.09(a)
      408252  NM_001001316.1  NP_001001316.1 
    lizard
    (Anolis carolinensis)
    Reptilia CTDSPL6
    Uncharacterized protein
    89(a)
    1 ↔ 1
    6(1195251-1218650)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.189312 Xenopus laevis NIF (NIF) mRNA, complete cds 81.32(n)    AY280863.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK361160.12   -- 78.76(n)    CK361160.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58306
    --
    46(a)
    1 → many
    3L(15985753-15997836)
    worm
    (Caenorhabditis elegans)
    Secernentea scpl-16
    Protein SCPL-1, isoform a
    28(a)
    1 → many
    I(10086392-10102012)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PSR11 Psr1p 52.99(n)
    57.8(a)
      850650   NP_013091.1 


    ENSEMBL Gene Tree for CTDSPL (if available)
    TreeFam Gene Tree for CTDSPL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTDSPL gene
    CTDSPL22  CTDSP12  CTDSP22  
    3 SIMAP similar genes for CTDSPL using alignment to 5 protein entries:     CTDSL_HUMAN (see all proteins):
    CTDSP2    CTDSP1    CTDNEP1

    CTDSPL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2294 SNPs in CTDSPL are shown (see all 2294)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
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    ----------
    VAR_0196854
    ----see VAR_0196852 V G mis40--------
    VAR_0196844
    ----see VAR_0196842 N S mis40--------
    VAR_0196834
    ----see VAR_0196832 S P mis40--------
    rs754369311,2
    C,F--37901730(+) CTCCTA/TCAGGT 2 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1124541401,2
    C--37901756(+) TCTGCG/-GGGCT 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1896782521,2
    C--37901922(+) CCACAC/GAAGAG 2 -- us2k10--------
    rs1835310211,2
    --37901934(+) TGGACA/CTGCCC 2 -- us2k10--------
    rs622415481,2
    C,F--37901957(+) GTGCGC/TGCGCA 2 -- us2k13Minor allele frequency- T:0.08NA WA 240
    rs1878750131,2
    --37902105(+) AGCCCG/TCCCTC 2 -- us2k10--------
    rs1907389071,2
    --37902106(+) GCCCGC/TCCTCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CTDSPL (37903451 - 38025960 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/22 variations for CTDSPL (see all 22):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676043CNV Deletion23128226
    esv2725159CNV Deletion23290073
    esv2422037CNV Deletion20811451
    nsv428416CNV Loss18775914
    nsv514147CNV Loss21397061
    dgv802n67CNV Loss20364138
    nsv437329CNV Loss16327808
    nsv517156CNV Loss19592680
    nsv437702CNV Loss16327808
    nsv522422CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608592    OMIM disorders: --

    13 diseases for CTDSPL:    About MalaCards
    pandas    azoospermia    renal cell carcinoma    acute myeloid leukemia
    sarcoma    myeloid leukemia    cervicitis    lung cancer
    prostate cancer    prostatitis    neuronitis    breast cancer
    leukemia


    CTDSPL for disorders           About GeneDecksing

    Genetic Association Database (GAD): CTDSPL
    Human Genome Epidemiology (HuGE) Navigator: CTDSPL (3 documents)

    Export disorders for CTDSPL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTDSPL gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with CTDSPL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line. (PubMed id 9179494)1, 2, 3 Ishikawa S.... Nakamura Y. (1997)
    2. An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies. (PubMed id 12543795)1, 3, 9 Protopopov A.... Zabarovsky E.R. (2003)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. (PubMed id 19047128)1, 4 Horikawa Y....Wu X. (2008)
    5. A genome-wide association study of breast and prostate cancer in the NHLBI's Framingham Heart Study. (PubMed id 17903305)1, 4 Murabito J.M....Hwang S.J. (2007)
    6. RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies. (PubMed id 15051889)1, 2 Kashuba V.I....Zabarovsky E.R. (2004)
    7. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. (PubMed id 12721286)1, 2 Yeo M....Gill G.N. (2003)
    8. High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer. (PubMed id 19478941)1, 9 Kashuba V.I....Zabarovsky E.R. (2009)
    9. MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia. (PubMed id 21643017)1 Zheng Y.S....Chen Y.Q. (2012)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10217 HGNC: 16890 AceView: CTDSPL Ensembl:ENSG00000144677 euGenes: HUgn10217
    ECgene: CTDSPL H-InvDB: CTDSPL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTDSPL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTDSPL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CTDSPL gene:
    Search GeneIP for patents involving CTDSPL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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