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CTDSP2 Gene

protein-coding   GIFtS: 56
GCID: GC12M058213

CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small
Phosphatase 21 2
     OS42 3
NLI-Interacting Factor 21 2 3     SCP22 3
Nuclear LIM Interactor-Interacting Factor 21 2 3     EC 3.1.3.163 8
Small CTD Phosphatase 21 2 3     PSR22
Conserved Gene Amplified In Osteosarcoma1 2     Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase
22
Protein OS-42 3     NIF23
Small C-Terminal Domain Phosphatase 22 3     

External Ids:    HGNC: 170771   Entrez Gene: 101062   Ensembl: ENSG000001752157   OMIM: 6087115   UniProtKB: O145953   

Export aliases for CTDSP2 gene to outside databases

Previous GC identifers: GC12M056499 GC12M055250


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CTDSP2 Gene:
CTDSP2 (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2) is a protein-coding gene. Diseases associated with CTDSP2 include adenosarcoma, and osteosarcoma. GO annotations related to this gene include CTD phosphatase activity. An important paralog of this gene is CTDSPL2.

UniProtKB/Swiss-Prot: CTDS2_HUMAN, O14595
Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the
C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II
transcription, possibly by controlling the transition from initiation/capping to processive transcript
elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in
non-neuronal cells. May contribute to the development of sarcomas

Gene Wiki entry for CTDSP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTDSP2 gene promoter:
         IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTDSP2 promoter sequence
   Search Chromatin IP Primers for CTDSP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTDSP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q14.1

CTDSP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTDSP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M058213:  view genomic region     (about GC identifiers)

Start:
58,213,710 bp from pter      End:
58,240,747 bp from pter
Size:
27,038 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CTDS2_HUMAN, O14595 (See protein sequence)
Recommended Name: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2  
Size: 271 amino acids; 30664 Da
Cofactor: Binds 1 magnesium ion per monomer
Subunit: Monomer (By similarity). Interacts with REST
Sequence caution: Sequence=AAB71816.1; Type=Frameshift; Positions=267; Sequence=AAP34399.1; Type=Frameshift;
Positions=267;
1 PDB 3D structure from and Proteopedia for CTDSP2:
2Q5E (3D)    
Secondary accessions: A8K5H4 Q53ZR2 Q6NZY3 Q9UEX1

Explore the universe of human proteins at neXtProt for CTDSP2: NX_O14595

Explore proteomics data for CTDSP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CTDSP2 (O14595) (see all 5)
     DNSPASY  NADFIVP  HQVYVLKRP  FTASLAKYADPV 


    See CTDSP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005721.3  
    ENSEMBL proteins: 
     ENSP00000381148   ENSP00000447046   ENSP00000448386   ENSP00000446705   ENSP00000448951  
     ENSP00000448299  
    Reactome Protein details: O14595

    CTDSP2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CTDSP2
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    Novus Biologicals CTDSP2 Proteins
    Novus Biologicals CTDSP2 Lysates
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    Cloud-Clone Corp. Proteins for CTDSP2

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    Cloud-Clone Corp. CLIAs for CTDSP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CTD: Serine/threonine phosphatases / CTD aspartate-based phosphatases

    3 InterPro protein domains:
     IPR023214 HAD-like_dom
     IPR011948 Dullard_phosphatase
     IPR004274 NIF

    Graphical View of Domain Structure for InterPro Entry O14595

    ProtoNet protein and cluster: O14595

    1 Blocks protein domain: IPB004274 NLI interacting factor

    UniProtKB/Swiss-Prot: CTDS2_HUMAN, O14595
    Similarity: Contains 1 FCP1 homology domain


    CTDSP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTDS2_HUMAN, O14595
    Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the
    C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II
    transcription, possibly by controlling the transition from initiation/capping to processive transcript
    elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in
    non-neuronal cells. May contribute to the development of sarcomas
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
    Induction: In primary sarcomas

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16724108
    GO:0008420CTD phosphatase activity IDA12721286
    GO:0016791phosphatase activity ----
    GO:0046872metal ion binding IEA--
         
    CTDSP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Ctdsp2 (no phenotypes)

    CTDSP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTDSP2
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    miRNA
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    miRTarBase miRNAs that target CTDSP2:
    hsa-mir-124-3p (MIRT002613), hsa-mir-106b-5p (MIRT044322), hsa-mir-193b-3p (MIRT016407), hsa-mir-615-3p (MIRT039866), hsa-mir-375 (MIRT019804), hsa-mir-24-3p (MIRT030513), hsa-mir-335-5p (MIRT017775)

    Block miRNA regulation of human, mouse, rat CTDSP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTDSP2 (see all 92):
    hsa-miR-194* hsa-miR-3678-3p hsa-miR-582-3p hsa-miR-1321 hsa-miR-15a hsa-miR-128 hsa-miR-759 hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat CTDSP2

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    Sino Biological Human cDNA Clone for CTDSP2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDSP2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDSP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTDS2_HUMAN, O14595: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    CTDSP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTDSP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    2Signaling by BMP
    BMP receptor signaling0.31
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Regulation of cytoplasmic and nuclear SMAD2/3 signaling
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling
    5Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for CTDSP2
        BMP receptor signaling
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling
    Coregulation of Androgen receptor activity


    1 Reactome Pathway for CTDSP2
        XBP1(S) activates chaperone genes



    CTDSP2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTDSP2
    Interactions:

        Search GeneGlobe Interaction Network for CTDSP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTDSP2 (O145951, 3 ENSP000003811484) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751, 3, ENSP000003638224EBI-2802973,EBI-608057 I2D: score=2 STRING: ENSP00000363822
    POLR2AP249283, ENSP000003149494I2D: score=1 STRING: ENSP00000314949
    SNAI1O958633, ENSP000002440504I2D: score=2 STRING: ENSP00000244050
    SMAD2ENSP000002621604STRING: ENSP00000262160
    POLR1AENSP000002638574STRING: ENSP00000263857
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IDA12721286
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--
    GO:0044267cellular protein metabolic process TAS--

    CTDSP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTDSP2 (CTDS2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CTDSP2 gene: 
    NM_005730.3  

    Unigene Cluster for CTDSP2:

    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
    Hs.524530  [show with all ESTs]
    Unigene Representative Sequence: NM_005730
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398073(uc010ssg.2 uc009zqf.3 uc001sqm.3 uc009zqg.3)
    ENST00000548823 ENST00000547169 ENST00000549039 ENST00000547701 ENST00000551594
    ENST00000550144 ENST00000552294
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CTDSP2 (see all 92):
    hsa-miR-194* hsa-miR-3678-3p hsa-miR-582-3p hsa-miR-1321 hsa-miR-15a hsa-miR-128 hsa-miR-759 hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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      QuantiTect SYBR Green Assays in human, mouse, rat CTDSP2
      QuantiFast Probe-based Assays in human, mouse, rat CTDSP2

    Additional mRNA sequence: 

    AF000152.1 AF022231.1 AK226076.1 AK291289.1 AK294930.1 AK310183.1 AK310873.1 AK311070.1 
    AK312413.1 AY279531.1 BC018922.2 BC065920.1 U09409.1 U81556.1 

    24 DOTS entries:

    DT.101963578  DT.100868113  DT.100652837  DT.449946  DT.95174954  DT.100652835  DT.91764701  DT.121115513 
    DT.91764707  DT.91764713  DT.100652838  DT.100652842  DT.95152094  DT.121115532  DT.87017361  DT.121115501 
    DT.121115508  DT.95091824  DT.95174964  DT.95174992  DT.95174993  DT.95348418  DT.121115553  DT.95174957 

    Selected AceView cDNA sequences (see all 672):

    N40264 BM678963 BQ217331 AI089244 AI471912 BM554837 AI268585 BQ889591 
    AW474554 BU730111 BQ026528 CA310110 BU149334 AA306471 AA868026 BQ448397 
    AW014622 CR594177 BQ877323 BE513580 BQ230814 BP377831 BU844959 BU151218 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CTDSP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
    SP1:        -                 -                 -                                                   
    SP2:        -                                   -                                                   
    SP3:                          -                 -                                                   
    SP4:                                            -           -                                       
    SP5:                                                                                                


    ECgene alternative splicing isoforms for CTDSP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTDSP2 expression in normal human tissues (normalized intensities)      CTDSP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTGATAAA
    CTDSP2 Expression
    About this image


    CTDSP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
    CTDSP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTDSP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524530

    UniProtKB/Swiss-Prot: CTDS2_HUMAN, O14595
    Tissue specificity: Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in
    liver

        Custom PCR Arrays for CTDSP2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDSP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CTDSP2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctdsp21 , 5 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more1, 5 90.25(n)1
    94.81(a)1
      10 (74.35 cM)5
    524681  NM_001113470.11  NP_001106941.11 
     1269787175 
    lizard
    (Anolis carolinensis)
    Reptilia CTDSP26
    CTD (carboxy-terminal domain, RNA polymerase II, p...
    85(a)
    1 ↔ 1
    2(67033474-67047647)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC057696.12   -- 79.97(n)    BC057696.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb16c042 wufb16c04 81.27(n)   321465  BC063974.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58306
    --
    44(a)
    1 → many
    3L(15985753-15997836)
    worm
    (Caenorhabditis elegans)
    Secernentea scpl-16
    Protein SCPL-1, isoform b
    30(a)
    1 → many
    I(10085713-10102012) WBGene00007054
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PSR11 PSR1 52.58(n)
    55.08(a)
      850650   NP_013091.1 


    ENSEMBL Gene Tree for CTDSP2 (if available)
    TreeFam Gene Tree for CTDSP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTDSP2 gene
    CTDSPL22  CTDSP12  CTDSPL2  
    4 SIMAP similar genes for CTDSP2 using alignment to 6 protein entries:     CTDS2_HUMAN (see all proteins):
    CTDSPL    CTDSP1    CTDNEP1    TIMM50

    CTDSP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CTDSP2
    PGOHUM00000246751


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTDSP2 (see all 484)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914688511,2
    --58215181(+) TAGGAA/GAGGGG 1 -- ut310--------
    rs1837339531,2
    --58215439(+) AAGAGG/TCTGAG 1 -- ut310--------
    rs1118814361,2
    C--58215463(+) TCAAGA/GGACAG 1 -- ut310--------
    rs1408667641,2
    --58215478(+) TTTCTA/GGCTAG 1 -- ut310--------
    rs1924042631,2
    --58215524(+) CCCCAC/TAGGCA 1 -- ut310--------
    rs1834495201,2
    --58215688(+) GAGAGC/TACGAA 1 -- ut310--------
    rs9375401,2
    C,F,A,H--58215707(+) TCTACC/TACCTG 1 -- ut3119Minor allele frequency- T:0.01NA NS EA CSA WA 1686
    rs115555551,2
    F--58215708(-) GCAGGT/CAGTAG 1 -- ut312Minor allele frequency- C:0.00NA 4
    rs1145742741,2
    F--58215709(+) TACTAC/GCTGCT 1 -- ut311Minor allele frequency- G:0.03WA 118
    rs1866259521,2
    --58215713(+) ACCTGA/CTTTTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CTDSP2 (58213710 - 58240747 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CTDSP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv726CNV Insertion18451855
    nsv826388CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTDSP2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608711    OMIM disorders: --

    5 diseases for CTDSP2:    About MalaCards
    adenosarcoma    osteosarcoma    hemochromatosis    sarcoma
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CTDSP2:
    Adenosarcoma

    CTDSP2 for disorders           About GeneDecksing


    Export disorders for CTDSP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTDSP2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with CTDSP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. (PubMed id 12721286)1, 2, 3 Yeo M.... Gill G.N. (J. Biol. Chem. 2003)
    2. Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas. (PubMed id 9315096)1, 2, 3 Su Y.A.... Meltzer P.S. (Oncogene 1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription. (PubMed id 16724108)1, 9 Thompson J....JAonne O.A. (EMBO J. 2006)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Small C-terminal domain phosphatase enhances snail activity through dephosphorylation. (PubMed id 19004823)1 Wu Y....Zhou B.P. (J. Biol. Chem. 2009)
    7. Structural genomics of protein phosphatases. (PubMed id 18058037)2 Almo S.C.... Burley S.K. (J. Struct. Funct. Genomics 2007)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10106 HGNC: 17077 AceView: CTDSP2 Ensembl:ENSG00000175215 euGenes: HUgn10106
    ECgene: CTDSP2 H-InvDB: CTDSP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTDSP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTDSP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTDSP2 gene:
    Search GeneIP for patents involving CTDSP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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