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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTDSP2 Gene

protein-coding   GIFtS: 56
GCID: GC12M058213

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide...
 Explore 5 diseases affiliated with
CTDSP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CTDSP2    

Aliases
for CTDSP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small
Phosphatase 21 2
     Small CTD Phosphatase 22 3
OS41 2 3     NLI-Interacting Factor 22 3
SCP21 2 3     EC 3.1.3.163 8
PSR21 2     Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 22
Nuclear LIM Interactor-Interacting Factor 22 3     Conserved Gene Amplified In Osteosarcoma2
Protein OS-42 3     NIF23
Small C-Terminal Domain Phosphatase 22 3     

External Ids:    HGNC: 170771   Entrez Gene: 101062   Ensembl: ENSG000001752157   OMIM: 6087115   UniProtKB: O145953   

Export aliases for CTDSP2 gene to outside databases

Previous GC identifers: GC12M056499 GC12M055250


Summaries
for CTDSP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CTDS2_HUMAN, O14595
Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the
C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II
transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal
cells. May contribute to the development of sarcomas

Gene Wiki entry for CTDSP2


Genomic Views
for CTDSP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTDSP2 gene promoter:
         IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CTDSP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CTDSP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTDSP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.1   Ensembl cytogenetic band:  12q14.1   HGNC cytogenetic band: 12q14.1

CTDSP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTDSP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M058213:  view genomic region     (about GC identifiers)

Start:
 58,213,710 bp from pter      End:
 58,240,747 bp from pter
Size:
 27,038 bases      Orientation:
 minus strand

Proteins
for CTDSP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CTDS2_HUMAN, O14595 (See protein sequence)
Recommended Name: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2  
Size: 271 amino acids; 30664 Da
Cofactor: Binds 1 magnesium ion per monomer
Subunit: Monomer (By similarity). Interacts with REST
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAB71816.1; Type=Frameshift; Positions=267; Sequence=AAP34399.1; Type=Frameshift;
Positions=267;
1 PDB 3D structure from and Proteopedia for CTDSP2:
2Q5E (3D)    
Secondary accessions: A8K5H4 Q53ZR2 Q6NZY3 Q9UEX1

Explore the universe of human proteins at neXtProt for CTDSP2: NX_O14595

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14595

    • 4/5 DME Specific Peptides for CTDSP2 (O14595) (see all 5)
     DNSPASY  NADFIVP  HQVYVLKRP  FTASLAKYADPV 

    CTDSP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005721.3  
    ENSEMBL proteins: 
     ENSP00000381148   ENSP00000447046   ENSP00000448386   ENSP00000446705   ENSP00000448951  
     ENSP00000448299  
    Reactome Protein details: O14595
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: CTDSP2
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    Novus Biologicals CTDSP2 Proteins
    Novus Biologicals CTDSP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CTDSP2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005654nucleoplasm TAS--


    CTDSP2 for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for CTDSP2

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    Uscn ELISAs and CLIAs for CTDSP2

    Protein Domains /
    Families
    for CTDSP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CTDSP2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023214 HAD-like_dom
     IPR011948 Dullard_phosphatase
     IPR004274 NIF

    Graphical View of Domain Structure for InterPro Entry O14595

    ProtoNet protein and cluster: O14595

    1 Blocks protein family: IPB004274 NLI interacting factor

    UniProtKB/Swiss-Prot: CTDS2_HUMAN, O14595
    Similarity: Contains 1 FCP1 homology domain


    Function
    for CTDSP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CTDS2_HUMAN, O14595
    Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the
    C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II
    transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.
    Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal
    cells. May contribute to the development of sarcomas
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Induction: In primary sarcomas

    Enzyme Number (IUBMB): EC 3.1.3.161 2

    miRNA
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    hsa-mir-124 (MIRT002613)

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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTDSP2
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate CTDSP2 (see all 92):
    hsa-miR-194* hsa-miR-3678-3p hsa-miR-582-3p hsa-miR-1321 hsa-miR-15a hsa-miR-128 hsa-miR-759 hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTDSP2 (see all 4)
    OriGene shRNA RFP: CTDSP2
    OriGene siRNA: CTDSP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTDSP2

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTDSP2 (see all 3)
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    Search LifeMap BioReagents cell lines for CTDSP2

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDSP2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008420CTD phosphatase activity IDA12721286
    GO:0016791phosphatase activity ----
    GO:0046872metal ion binding IEA--


    CTDSP2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CTDSP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of Chaperone Genes by XBP1(S)
    		Activation of Chaperone Genes by XBP1(S)1.00
    		Unfolded Protein Response0.71
    		Activation of Chaperones by IRE1alpha0.94
    2Expression of CTDSP2
    		Expression of CTDSP21.00
    3Coregulation of Androgen receptor activity
    		Coregulation of Androgen receptor activity1.00
    4Regulation of cytoplasmic and nuclear SMAD2/3 signaling
    		Regulation of cytoplasmic and nuclear SMAD2/3 signaling1.00
    5Signaling by BMP
    		BMP receptor signaling0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for CTDSP2 
        Regulation of cytoplasmic and nuclear SMAD2/3 signaling
    BMP receptor signaling
    Coregulation of Androgen receptor activity

    5        Reactome Pathways for CTDSP2
        Activation of Chaperone Genes by XBP1(S)
    Expression of CTDSP2
    Metabolism of proteins
    Activation of Chaperones by IRE1alpha
    Unfolded Protein Response



    CTDSP2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTDSP2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CTDSP2 (O145953 ENSP000003811484) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    POLR2AP249283, ENSP000003149494I2D: score=1 STRING: ENSP00000314949
    SNAI1O958633, ENSP000002440504I2D: score=2 STRING: ENSP00000244050
    SMAD2ENSP000002621604STRING: ENSP00000262160
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IDA12721286
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--


    CTDSP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CTDSP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTDSP2
    Search CenterWatch for drugs/clinical trials and news about CTDSP2 / CTDS2 

    Transcripts
    for CTDSP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CTDSP2 gene: 
    NM_005730.3  

    Unigene Cluster for CTDSP2:

    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
    Hs.524530  [show with all ESTs]
    Unigene Representative Sequence: NM_005730
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398073(uc010ssg.2 uc009zqf.3 uc001sqm.3 uc009zqg.3)
    ENST00000548823 ENST00000547169 ENST00000549039 ENST00000547701 ENST00000551594
    ENST00000550144 ENST00000552294

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CTDSP2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTDSP2
    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate CTDSP2 (see all 92):
    hsa-miR-194* hsa-miR-3678-3p hsa-miR-582-3p hsa-miR-1321 hsa-miR-15a hsa-miR-128 hsa-miR-759 hsa-miR-877*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTDSP2 (see all 4)
    OriGene shRNA RFP: CTDSP2
    OriGene siRNA: CTDSP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTDSP2
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CTDSP2 (NM_005730)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTDSP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDSP2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CTDSP2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTDSP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTDSP2

    Additional cDNA sequence: 

    AF000152.1 AF022231.1 AK226076.1 AK291289.1 AK294930.1 AK310183.1 AK310873.1 AK311070.1 
    AK312413.1 AY279531.1 BC018922.2 BC065920.1 U09409.1 U81556.1 

    24 DOTS entries:

    DT.101963578  DT.100868113  DT.100652837  DT.449946  DT.95174954  DT.100652835  DT.91764701  DT.121115513 
    DT.91764707  DT.91764713  DT.100652838  DT.100652842  DT.95152094  DT.121115532  DT.87017361  DT.121115501 
    DT.121115508  DT.95091824  DT.95174964  DT.95174992  DT.95174993  DT.95348418  DT.121115553  DT.95174957 

    24/672 AceView cDNA sequences (see all 672):

    CB215373 AI660487 AA351871 BQ448397 BE295801 BQ777184 BQ427552 AA811327 
    BU931707 AA424489 BE741103 AW327815 CK724879 BU741904 AI279575 BM142340 
    AA306471 AI355616 BE672036 BM722442 BU508262 CF125384 BM703934 BQ026528 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CTDSP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
    SP1:        -                 -                 -                                                   
    SP2:        -                                   -                                                   
    SP3:                          -                 -                                                   
    SP4:                                            -           -                                       
    SP5:                                                                                                


    ECgene alternative splicing isoforms for CTDSP2

    Expression
    for CTDSP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTDSP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTTGATAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CTDSP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CTDSP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTDSP2

    SOURCE GeneReport for Unigene cluster: Hs.524530

    UniProtKB/Swiss-Prot: CTDS2_HUMAN, O14595
    Tissue specificity: Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in
    liver

        SABiosciences Custom PCR Arrays for CTDSP2
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDSP2

    Orthologs
    for CTDSP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CTDSP2 gene from 5/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia CTDSP26
    		 --
    		 88(a)
    		 1 ↔ 1
    		 2(67037063-67048577)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC057696.12   -- 79.97(n)    BC057696.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb16c042 wufb16c04 81.27(n)   321465  BC063974.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG58306
    		 --
    		 42(a)
    		 1 → many
    		 3L(15985753-15997836)
    worm
    (Caenorhabditis elegans)    		 Secernentea scpl-16
    		 SCP(Small C-terminal domain Phosphatase)-Like phos...
    		 28(a)
    		 possible ortholog
    		 I(10086381-10102001)


    ENSEMBL Gene Tree for CTDSP2 (if available)
    TreeFam Gene Tree for CTDSP2 (if available) 

    Paralogs
    for CTDSP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTDSP2 gene
    CTDSPL22  CTDSP12  CTDSPL2  
    4 SIMAP similar genes for CTDSP2 using alignment to 6 protein entries:     CTDS2_HUMAN (see all proteins):
    CTDSPL    CTDSP1    CTDNEP1    TIMM50

    CTDSP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CTDSP2
    PGOHUM00000246751


    Genomic Variants
    for CTDSP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/441 NCBI SNPs in CTDSP2 are shown (see all 441)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1117266451,2
    		C,--55250358(+) CAAGAC/TTCCAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs2010058571,2
    		C--55250387(-) GGATTA/TTTATT 1 -- us2k10--------
    rs10594701,2
    		C--55250884(-) TTCAAG/AATGCC 1 -- us2k12Minor allele frequency- A:0.00NA 4
    rs1115530151,2
    		--55250897(+) GGGAAA/GGCGGC 1 -- us2k10--------
    rs1130765201,2
    		--55250944(+) GCCCAA/GAGAGG 1 -- us2k10--------
    rs115555541,2
    		C--55251595(-) GGCTTC/TTAAAT 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1907082941,2
    		--58213229(+) GAAACC/TCCATC 2 -- int1 us2k10--------
    rs1479786681,2
    		--58213271(+) GCTGGC/TAGGCG 2 -- us2k1 int10--------
    rs111723501,2
    		C,F,A,--58213272(+) CTGGCG/AGGCGC 2 -- int1 us2k13Minor allele frequency- A:0.50NA WA 6
    rs47601701,2
    		C,H--58213419(+) AAAAAA/TAATAA 2 -- us2k1 int15Minor allele frequency- T:0.00NA WA 10

    HapMap Linkage Disequilibrium report for CTDSP2 (58213710 - 58240747 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CTDSP2: --

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    Disorders / Diseases
    for CTDSP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CTDSP2 for disorders           About GeneDecksing

    OMIM gene information: 608711    OMIM disorders: --

    5 diseases for CTDSP2:    About MalaCards
    osteosarcoma    adenosarcoma    hemochromatosis    sarcoma
    neuronitis


    Export disorders for CTDSP2 gene to outside databases

    Publications
    for CTDSP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTDSP2 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with CTDSP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. (PubMed id 12721286)1, 2, 3 Yeo M....Gill G.N. (2003)
    2. Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas. (PubMed id 9315096)1, 2, 3 Su Y.A.... Meltzer P.S. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription. (PubMed id 16724108)1, 9 Thompson J....Janne O.A. (2006)
    5. Small C-terminal domain phosphatase enhances snail activity through dephosphorylation. (PubMed id 19004823)1 Wu Y....Zhou B.P. (2009)
    6. Structural genomics of protein phosphatases. (PubMed id 18058037)2 Almo S.C....Burley S.K. (2007)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
    10. Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways. (PubMed id 17085434)1 Sapkota G....Massague J. (2006)

    External Searches for CTDSP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing CTDSP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10106 HGNC: 17077 AceView: CTDSP2 Ensembl:ENSG00000175215 euGenes: HUgn10106
    ECgene: CTDSP2 H-InvDB: CTDSP2

    Other Databases showing CTDSP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CTDSP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTDSP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CTDSP2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CTDSP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CTDSP2 gene:
    Search GeneIP for patents involving CTDSP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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