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Aliases for CTDSP2 Gene

Aliases for CTDSP2 Gene

  • CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 2 3
  • Nuclear LIM Interactor-Interacting Factor 2 2 3 4
  • NLI-Interacting Factor 2 2 3 4
  • Small CTD Phosphatase 2 2 3 4
  • Conserved Gene Amplified In Osteosarcoma 2 3
  • Small C-Terminal Domain Phosphatase 2 3 4
  • Protein OS-4 3 4
  • EC 3.1.3.16 4 63
  • SCP2 3 4
  • OS4 3 4
  • Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 2 3
  • PSR2 3
  • NIF2 4

External Ids for CTDSP2 Gene

Previous GeneCards Identifiers for CTDSP2 Gene

  • GC12M056499
  • GC12M058213
  • GC12M055250

Summaries for CTDSP2 Gene

GeneCards Summary for CTDSP2 Gene

CTDSP2 (CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2) is a Protein Coding gene. Diseases associated with CTDSP2 include adenosarcoma. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include CTD phosphatase activity. An important paralog of this gene is CTDSPL.

UniProtKB/Swiss-Prot for CTDSP2 Gene

  • Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.

Gene Wiki entry for CTDSP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTDSP2 Gene

Genomics for CTDSP2 Gene

Regulatory Elements for CTDSP2 Gene

Transcription factor binding sites by QIAGEN in the CTDSP2 gene promoter:

Genomic Location for CTDSP2 Gene

Start:
57,819,927 bp from pter
End:
57,846,964 bp from pter
Size:
27,038 bases
Orientation:
Minus strand

Genomic View for CTDSP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTDSP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTDSP2 Gene

Proteins for CTDSP2 Gene

  • Protein details for CTDSP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14595-CTDS2_HUMAN
    Recommended name:
    Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
    Protein Accession:
    O14595
    Secondary Accessions:
    • A8K5H4
    • Q53ZR2
    • Q6NZY3
    • Q9UEX1

    Protein attributes for CTDSP2 Gene

    Size:
    271 amino acids
    Molecular mass:
    30664 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per monomer.;
    Quaternary structure:
    • Monomer (By similarity). Interacts with REST.
    SequenceCaution:
    • Sequence=AAB71816.1; Type=Frameshift; Positions=267; Evidence={ECO:0000305}; Sequence=AAP34399.1; Type=Frameshift; Positions=267; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CTDSP2 Gene

neXtProt entry for CTDSP2 Gene

Proteomics data for CTDSP2 Gene at MOPED

Selected DME Specific Peptides for CTDSP2 Gene

Post-translational modifications for CTDSP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTDSP2 Gene

Domains for CTDSP2 Gene

Gene Families for CTDSP2 Gene

HGNC:
  • CTD :Serine/threonine phosphatases / CTD aspartate-based phosphatases

Protein Domains for CTDSP2 Gene

Suggested Antigen Peptide Sequences for CTDSP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14595

UniProtKB/Swiss-Prot:

CTDS2_HUMAN :
  • O14595
Domain:
  • Contains 1 FCP1 homology domain.
genes like me logo Genes that share domains with CTDSP2: view

Function for CTDSP2 Gene

Molecular function for CTDSP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
UniProtKB/Swiss-Prot Induction: In primary sarcomas

Enzyme Numbers (IUBMB) for CTDSP2 Gene

Gene Ontology (GO) - Molecular Function for CTDSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16724108
GO:0008420 CTD phosphatase activity IDA 12721286
GO:0016791 phosphatase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CTDSP2: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CTDSP2 Gene

Localization for CTDSP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTDSP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTDSP2 Gene COMPARTMENTS Subcellular localization image for CTDSP2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for CTDSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CTDSP2: view

Pathways for CTDSP2 Gene

genes like me logo Genes that share pathways with CTDSP2: view

Gene Ontology (GO) - Biological Process for CTDSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006470 protein dephosphorylation IDA 12721286
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0016311 dephosphorylation --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
genes like me logo Genes that share ontologies with CTDSP2: view

Transcripts for CTDSP2 Gene

Unigene Clusters for CTDSP2 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTDSP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for CTDSP2 Gene

GeneLoc Exon Structure for
CTDSP2
ECgene alternative splicing isoforms for
CTDSP2

Expression for CTDSP2 Gene

mRNA expression in normal human tissues for CTDSP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CTDSP2 Gene

SOURCE GeneReport for Unigene cluster for CTDSP2 Gene Hs.524530

mRNA Expression by UniProt/SwissProt for CTDSP2 Gene

O14595-CTDS2_HUMAN
Tissue specificity: Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver.
genes like me logo Genes that share expressions with CTDSP2: view

No data available for mRNA differential expression in normal tissues for CTDSP2 Gene

Orthologs for CTDSP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTDSP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTDSP2 35
  • 99.51 (n)
  • 100 (a)
CTDSP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTDSP2 35
  • 93.6 (n)
  • 98.52 (a)
CTDSP2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTDSP2 35
  • 93.6 (n)
  • 98.15 (a)
CTDSP2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctdsp2 35
  • 90.25 (n)
  • 94.81 (a)
Ctdsp2 16
Ctdsp2 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTDSP2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTDSP2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTDSP2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctdsp2 35
  • 75.68 (n)
  • 80.37 (a)
Str.2966 35
zebrafish
(Danio rerio)
Actinopterygii ctdsp2 35
  • 71.35 (n)
  • 76.95 (a)
ctdsp2 36
  • 76 (a)
OneToOne
wufb16c04 35
fruit fly
(Drosophila melanogaster)
Insecta CG5830 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scpl-1 36
  • 30 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL158W 35
  • 52.93 (n)
  • 56.04 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSR1 35
  • 52.58 (n)
  • 55.08 (a)
PSR1 36
  • 27 (a)
ManyToMany
PSR2 36
  • 28 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15620g 35
  • 54.97 (n)
  • 53.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToMany
Species with no ortholog for CTDSP2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTDSP2 Gene

ENSEMBL:
Gene Tree for CTDSP2 (if available)
TreeFam:
Gene Tree for CTDSP2 (if available)

Paralogs for CTDSP2 Gene

Paralogs for CTDSP2 Gene

Selected SIMAP similar genes for CTDSP2 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CTDSP2 Gene

genes like me logo Genes that share paralogs with CTDSP2: view

Variants for CTDSP2 Gene

Sequence variations from dbSNP and Humsavar for CTDSP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs937540 -- 57,821,924(+) TCTAC(C/T)ACCTG utr-variant-3-prime
rs1599750 -- 57,848,762(+) TGCTA(G/T)GGGGG upstream-variant-2KB
rs1801928 -- 57,820,799(-) CTTTG(A/G)ACACA utr-variant-3-prime
rs1804791 -- 57,821,210(-) AGCTA(C/T)TCGGC utr-variant-3-prime
rs1875125 -- 57,833,458(+) TCCCT(G/T)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTDSP2 Gene

Variant ID Type Subtype PubMed ID
nsv726 CNV Insertion 18451855
nsv826388 CNV Gain 20364138

Relevant External Links for CTDSP2 Gene

HapMap Linkage Disequilibrium report
CTDSP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTDSP2 Gene

Disorders for CTDSP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CTDSP2 Gene including...

Search for CTDSP2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CTDSP2 Gene

genes like me logo Genes that share disorders with CTDSP2: view

No data available for UniProtKB/Swiss-Prot for CTDSP2 Gene

Publications for CTDSP2 Gene

  1. Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas. (PMID: 9315096) Su Y.A. … Meltzer P.S. (Oncogene 1997) 2 3 4
  2. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. (PMID: 12721286) Yeo M. … Gill G.N. (J. Biol. Chem. 2003) 2 3 4
  3. Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription. (PMID: 16724108) Thompson J. … JAonne O.A. (EMBO J. 2006) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CTDSP2 Gene

Sources for CTDSP2 Gene

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