Aliases for CTDSP1 Gene
External Ids for CTDSP1 Gene
Previous GeneCards Identifiers for CTDSP1 Gene
This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for CTDSP1 Gene
CTDSP1 (CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1) is a Protein Coding gene. Among its related pathways are Coregulation of Androgen receptor activity and Signaling by BMP. GO annotations related to this gene include phosphatase activity and CTD phosphatase activity. An important paralog of this gene is CTDSPL.
UniProtKB/Swiss-Prot for CTDSP1 Gene
Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.