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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTDSP1 Gene

protein-coding   GIFtS: 57
GCID: GC02P219262

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide...
 Explore 3 diseases affiliated with
CTDSP1 via
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Biological research products
for CTDSP1    

Aliases
for CTDSP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small
Phosphatase 11 2
     NLI-IF2 3
NLIIF1 2 3 5     NLI-Interacting Factor 32 3
SCP11 2 3 5     EC 3.1.3.163 8
Nuclear LIM Interactor-Interacting Factor 32 3     Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 12
Small C-Terminal Domain Phosphatase 12 3     Small CTD Phosphatase 13
NIF32 3     

External Ids:    HGNC: 216141   Entrez Gene: 581902   Ensembl: ENSG000001445797   OMIM: 6053235   UniProtKB: Q9GZU73   

Export aliases for CTDSP1 gene to outside databases

Previous GC identifers: GC02P219467 GC02P219091 GC02P218972 GC02P211117


Summaries
for CTDSP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CTDSP1:
This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These
proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem
heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene
silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript
variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: CTDS1_HUMAN, Q9GZU7
Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the
C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II
transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal
cells

Gene Wiki entry for CTDSP1


Genomic Views
for CTDSP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTDSP1 gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   E2F-2   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CTDSP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CTDSP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTDSP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

CTDSP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTDSP1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219262:  view genomic region     (about GC identifiers)

Start:
 219,262,979 bp from pter      End:
 219,270,664 bp from pter
Size:
 7,686 bases      Orientation:
 plus strand

Proteins
for CTDSP1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CTDS1_HUMAN, Q9GZU7 (See protein sequence)
Recommended Name: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1  
Size: 261 amino acids; 29203 Da
Cofactor: Binds 1 magnesium ion per monomer
Subunit: Monomer (By similarity). Interacts with GTF2F1. Interacts with REST
Subcellular location: Nucleus. Note=Colocalizes with RNA polymerase II
Sequence caution: Sequence=AAP34398.1; Type=Frameshift; Positions=72;
6/8 PDB 3D structures from and Proteopedia for CTDSP1 (see all 8):
1T9Z (3D)        1TA0 (3D)        2GHQ (3D)        2GHT (3D)        3L0B (3D)        3L0C (3D)    
Secondary accessions: C9IYG0 Q7Z5Q3 Q7Z5Q4
Alternative splicing: 3 isoforms:  Q9GZU7-1   Q9GZU7-2   Q9GZU7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CTDSP1: NX_Q9GZU7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9GZU7

    • 4/5 DME Specific Peptides for CTDSP1 (Q9GZU7) (see all 5)
     GNYVKDL  DNSPASY  HQVYVLKRP  FTASLAKYADPV 

    CTDSP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193807.1  NP_067021.1  NP_872580.1  

    ENSEMBL proteins: 
     ENSP00000392248   ENSP00000273062   ENSP00000404301   ENSP00000403256   ENSP00000411308  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): CTDSP1
    OriGene Protein Over-expression Lysate (see all 2): CTDSP1
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    Novus Biologicals CTDSP1 Proteins
    Novus Biologicals CTDSP1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for CTDSP1
    Uscn Proteins for CTDSP1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10967134


    CTDSP1 for ontologies           About GeneDecksing



    CTDSP1 Antibody Products: 
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    Uscn Antibodies for CTDSP1
    ThermoFisher Antibodies for CTDSP1

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    Uscn ELISAs and CLIAs for CTDSP1

    Protein Domains /
    Families
    for CTDSP1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CTDSP1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023214 HAD-like_dom
     IPR011948 Dullard_phosphatase
     IPR004274 NIF

    Graphical View of Domain Structure for InterPro Entry Q9GZU7

    ProtoNet protein and cluster: Q9GZU7

    1 Blocks protein family: IPB004274 NLI interacting factor

    UniProtKB/Swiss-Prot: CTDS1_HUMAN, Q9GZU7
    Similarity: Contains 1 FCP1 homology domain


    Function
    for CTDSP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CTDS1_HUMAN, Q9GZU7
    Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the
    C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II
    transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.
    Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal
    cells
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Enzyme regulation: Stimulated by GTF2F1. Inhibited by beryllofluoride anions
    Biophysicochemical properties: pH dependence: Optimum pH is 5;

    Enzyme Number (IUBMB): EC 3.1.3.161 2

    miRNA
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    hsa-mir-124 (MIRT002729)

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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CTDSP1 (see all 21):
    hsa-miR-148b* hsa-miR-1271 hsa-miR-486-3p hsa-miR-500a hsa-miR-888* hsa-miR-124 hsa-miR-501-5p hsa-miR-296-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CTDSP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTDSP1 (see all 7)
    OriGene shRNA RFP: CTDSP1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTDSP1

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12721286
    GO:0008420CTD phosphatase activity IDA12721286
    GO:0016791phosphatase activity ----
    GO:0046872metal ion binding IEA--


    CTDSP1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CTDSP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of cytoplasmic and nuclear SMAD2/3 signaling
    		Regulation of cytoplasmic and nuclear SMAD2/3 signaling1.00
    2Coregulation of Androgen receptor activity
    		Coregulation of Androgen receptor activity1.00
    3Signaling by BMP
    		BMP receptor signaling0.31


    3 BioSystems Pathways for CTDSP1 
        Coregulation of Androgen receptor activity
    BMP receptor signaling
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTDSP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for CTDSP1 (Q9GZU72, 3 ENSP000002730624) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDCA3Q996182, 3, ENSP000002292654MINT-68177 I2D: score=5 STRING: ENSP00000229265
    LDB1Q86U703, ENSP000003924664I2D: score=1 STRING: ENSP00000392466
    GTF2F1P352693, ENSP000003779694I2D: score=1 STRING: ENSP00000377969
    MBPP026863, ENSP000003482734I2D: score=1 STRING: ENSP00000348273
    POLR2AP249283, ENSP000003149494I2D: score=2 STRING: ENSP00000314949
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA12721286
    GO:0006470protein dephosphorylation IDA12721286
    GO:0045665negative regulation of neuron differentiation IEA--
    GO:0050768negative regulation of neurogenesis IEA--


    CTDSP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CTDSP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTDSP1

    3 HMDB Compounds for CTDSP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for CTDSP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aspartate Beryllium Trifluoride-- --target--17139284 17016423 10592235
    Citric Acid-- 77-92-9target--17139284 17016423 10592235

    Search CenterWatch for drugs/clinical trials and news about CTDSP1 / CTDS1 

    Transcripts
    for CTDSP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CTDSP1 gene (4 alternative transcripts): 
    NM_001206878.1  NM_021198.2  NM_182642.2  NM_001206879.1  

    Unigene Cluster for CTDSP1:

    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
    Hs.444468  [show with all ESTs]
    Unigene Representative Sequence: AF229162
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491064 ENST00000443891 ENST00000492545 ENST00000473420 ENST00000498160
    ENST00000273062(uc021vwv.1 uc002vhx.3 uc002vhy.3 uc002vhz.3)
    ENST00000497677 ENST00000494067 ENST00000452977 ENST00000428361 ENST00000496785
    ENST00000431127 ENST00000488627 ENST00000482272 ENST00000464255

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTDSP1
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CTDSP1 (see all 21):
    hsa-miR-148b* hsa-miR-1271 hsa-miR-486-3p hsa-miR-500a hsa-miR-888* hsa-miR-124 hsa-miR-501-5p hsa-miR-296-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CTDSP1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTDSP1 (see all 7)
    OriGene shRNA RFP: CTDSP1
    OriGene siRNA: CTDSP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTDSP1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): CTDSP1 (NM_021198)
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    Primer
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    Additional cDNA sequence: 

    AF217969.1 AF229162.1 AF258582.1 AK075090.1 AY279529.1 AY279530.1 BC012977.2 

    18 DOTS entries:

    DT.115679  DT.100811863  DT.100772643  DT.100811866  DT.40262275  DT.95332856  DT.101954918  DT.95083331 
    DT.75155544  DT.92459251  DT.95083330  DT.100811865  DT.91867513  DT.95083318  DT.95083319  DT.95315128 
    DT.97862167  DT.99956245 

    24/326 AceView cDNA sequences (see all 326):

    BX095079 BM771982 AL524545 Z40235 AF217969 AF229162 BM694082 AI634638 
    BM684398 BM975639 BG392753 BM853080 AW673969 NM_021198 AA566001 BC012977 
    BM930874 CA502813 BM820305 AF258582 F31081 CA428041 AA687943 BG830225 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CTDSP1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e
    SP1:              -     -     -     -     -     -     -     -                       -                                                         
    SP2:                                            -     -     -                       -                                                         
    SP3:                                            -     -     -                       -                                                         
    SP4:                                                        -                       -                                                         
    SP5:                          -     -     -     -     -     -                       -                                                         


    ECgene alternative splicing isoforms for CTDSP1

    Expression
    for CTDSP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTDSP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCGATTCCGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CTDSP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTDSP1

    SOURCE GeneReport for Unigene cluster: Hs.444468

    UniProtKB/Swiss-Prot: CTDS1_HUMAN, Q9GZU7
    Tissue specificity: Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen,
    lung and placenta

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    In Situ
    Assay Products:     
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    Orthologs
    for CTDSP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CTDSP1 gene from 5/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC1008577541 carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1-like less 77.82(n)
    80(a)    		   100857754  XM_003641649.1  XP_003641697.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CTDSP16
    		 --
    		 81(a)
    		 1 ↔ 1
    		 1(88577991-88587496)
    zebrafish
    (Danio rerio)    		 Actinopterygii ctdsp11 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 less 70.16(n)
    77.52(a)    		   553744  NM_001020715.2  NP_001018551.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG58301 CG5830 60.64(n)
    63.45(a)    		   39748  NM_140568.1  NP_648825.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea scpl-11 Protein SCPL-1 55.25(n)
    59.76(a)    		   181944  NM_170918.3  NP_740912.2 


    ENSEMBL Gene Tree for CTDSP1 (if available)
    TreeFam Gene Tree for CTDSP1 (if available) 

    Paralogs
    for CTDSP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CTDSP1 gene
    CTDSPL22  CTDSPL2  CTDSP22  
    4 SIMAP similar genes for CTDSP1 using alignment to 4 protein entries:     CTDS1_HUMAN (see all proteins):
    CTDSPL    CTDSP2    CTDSPL2    CTDNEP1

    CTDSP1 for paralogs           About GeneDecksing



    Genomic Variants
    for CTDSP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/177 NCBI SNPs in CTDSP1 are shown (see all 177)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs18092311,2
    		C,F,A,H,--219262179(-) GTGCAC/GAAAGT 1 -- us2k115Minor allele frequency- G:0.49NA WA CSA EA 511
    rs1893797151,2
    		--219262225(+) GCCCTA/GTTTGG 1 -- us2k10--------
    rs1814241431,2
    		--219262423(+) GTAGAA/GACAGA 1 -- us2k10--------
    rs38065541,2
    		C,F,--219262497(+) AATCCC/G/TGGCCT 3 -- us2k11EA 120
    rs730730951,2
    		C,F,--219262508(+) CTCGCT/ACACTC 3 -- us2k13Minor allele frequency- A:0.11WA 122
    rs101890621,2
    		C,F,--219262538(+) CAGGCG/ATGGGG 3 -- us2k11Minor allele frequency- A:0.06WA 118
    rs730730971,2
    		C,F,--219262583(+) TACCTC/TTGCCG 3 -- us2k13Minor allele frequency- T:0.10WA 122
    rs739904751,2
    		C,F,--219262708(+) GTGAGC/TTCAGG 3 -- us2k13Minor allele frequency- T:0.05WA CSA 122
    rs1837513191,2
    		--219262817(+) GCGAGA/GCCACG 3 -- us2k10--------
    rs621821231,2
    		--219262887(+) AGATAA/GAGCCG 3 -- us2k12Minor allele frequency- G:0.05NA 122

    HapMap Linkage Disequilibrium report for CTDSP1 (219262979 - 219270664 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CTDSP1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTDSP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CTDSP1

    Disorders / Diseases
    for CTDSP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CTDSP1 for disorders           About GeneDecksing

    OMIM gene information: 605323    OMIM disorders: --

    3 diseases for CTDSP1:    About MalaCards
    neuronitis    tuberculosis    sarcoma

    Human Genome Epidemiology (HuGE) Navigator: CTDSP1 (3 documents)

    Export disorders for CTDSP1 gene to outside databases

    Publications
    for CTDSP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTDSP1 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with CTDSP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. (PubMed id 12721286)1, 2, 3, 9 Yeo M....Gill G.N. (2003)
    2. Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35. (PubMed id 10967134)1, 2, 9 Marquet S.... Schurr E. (2000)
    3. Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility. (PubMed id 11950066)1, 3, 9 Ma X....Graviss E. (2002)
    4. Small CTD phosphatases function in silencing neuronal gene expression. (PubMed id 15681389)1, 2 Yeo M....Gill G.N. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Determinants for dephosphorylation of the RNA polymerase II C- terminal domain by Scp1. (PubMed id 17157258)2, 9 Zhang Y.... Noel J.P. (2006)
    7. Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous system. (PubMed id 14743429)1, 9 Fernandes A.O....Campagnoni A.T. (2004)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Suppression of BMP-Smad signaling axis-induced osteob lastic differentiation by small C-terminal domain phosphatase 1, a Smad phospha tase. (PubMed id 21239611)1 Kokabu S....Katagiri T. (2011)
    10. Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor. (PubMed id 21348431)1 Zhang M....Zhang Y. (2011)

    External Searches for CTDSP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CTDSP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58190 HGNC: 21614 AceView: CTDSP1 Ensembl:ENSG00000144579 euGenes: HUgn58190
    ECgene: CTDSP1 H-InvDB: CTDSP1

    Other Databases showing CTDSP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CTDSP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTDSP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CTDSP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CTDSP1 gene:
    Search GeneIP for patents involving CTDSP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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