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CTDSP1 Gene

protein-coding   GIFtS: 60
GCID: GC02P219262

CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small
Phosphatase 11 2
     NIF32 3
NLIIF2 3 5     NLI-IF2 3
SCP12 3 5     NLI-Interacting Factor 32 3
Small CTD Phosphatase 11 3     EC 3.1.3.163 8
Nuclear LIM Interactor-Interacting Factor 32 3     Nuclear LIM Interactor-Interacting Factor1
Small C-Terminal Domain Phosphatase 12 3     Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase
12

External Ids:    HGNC: 216141   Entrez Gene: 581902   Ensembl: ENSG000001445797   OMIM: 6053235   UniProtKB: Q9GZU73   

Export aliases for CTDSP1 gene to outside databases

Previous GC identifers: GC02P219467 GC02P219091 GC02P218972 GC02P211117


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTDSP1 Gene:
This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These
proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within
tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in
neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Oct
2011)

GeneCards Summary for CTDSP1 Gene:
CTDSP1 (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1) is a protein-coding gene. GO annotations related to this gene include CTD phosphatase activity. An important paralog of this gene is CTDSPL2.

UniProtKB/Swiss-Prot: CTDS1_HUMAN, Q9GZU7
Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the
C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II
transcription, possibly by controlling the transition from initiation/capping to processive transcript
elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in
non-neuronal cells

Gene Wiki entry for CTDSP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTDSP1 gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   E2F-2   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTDSP1 promoter sequence
   Search Chromatin IP Primers for CTDSP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTDSP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

CTDSP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTDSP1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P219262:  view genomic region     (about GC identifiers)

Start:
219,262,979 bp from pter      End:
219,270,664 bp from pter
Size:
7,686 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTDS1_HUMAN, Q9GZU7 (See protein sequence)
Recommended Name: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1  
Size: 261 amino acids; 29203 Da
Cofactor: Binds 1 magnesium ion per monomer
Subunit: Monomer (By similarity). Interacts with GTF2F1. Interacts with REST
Sequence caution: Sequence=AAP34398.1; Type=Frameshift; Positions=72;
Selected PDB 3D structures from and Proteopedia for CTDSP1 (see all 8):
1T9Z (3D)        1TA0 (3D)        2GHQ (3D)        2GHT (3D)        3L0B (3D)        3L0C (3D)    
Secondary accessions: C9IYG0 Q7Z5Q3 Q7Z5Q4
Alternative splicing: 3 isoforms:  Q9GZU7-1   Q9GZU7-2   Q9GZU7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CTDSP1: NX_Q9GZU7

Explore proteomics data for CTDSP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CTDSP1 (Q9GZU7) (see all 5)
     GNYVKDL  DNSPASY  HQVYVLKRP  FTASLAKYADPV 


    See CTDSP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193807.1  NP_067021.1  NP_872580.1  

    ENSEMBL proteins: 
     ENSP00000392248   ENSP00000273062   ENSP00000404301   ENSP00000403256   ENSP00000411308  

    CTDSP1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CTD: Serine/threonine phosphatases / CTD aspartate-based phosphatases

    3 InterPro protein domains:
     IPR023214 HAD-like_dom
     IPR011948 Dullard_phosphatase
     IPR004274 NIF

    Graphical View of Domain Structure for InterPro Entry Q9GZU7

    ProtoNet protein and cluster: Q9GZU7

    1 Blocks protein domain: IPB004274 NLI interacting factor

    UniProtKB/Swiss-Prot: CTDS1_HUMAN, Q9GZU7
    Similarity: Contains 1 FCP1 homology domain


    Find genes that share domains with CTDSP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTDS1_HUMAN, Q9GZU7
    Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the
    C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II
    transcription, possibly by controlling the transition from initiation/capping to processive transcript
    elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in
    non-neuronal cells
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
    Enzyme regulation: Stimulated by GTF2F1. Inhibited by beryllofluoride anions
    Biophysicochemical properties: pH dependence: Optimum pH is 5;

         Enzyme Number (IUBMB): EC 3.1.3.161 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12721286
    GO:0008420CTD phosphatase activity IDA12721286
    GO:0016791phosphatase activity ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with CTDSP1           About GenesLikeMe


    Animal Models:
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    miRTarBase miRNAs that target CTDSP1:
    hsa-mir-24-3p (MIRT030562), hsa-mir-125b-5p (MIRT045998), hsa-mir-124-3p (MIRT002729), hsa-mir-7-5p (MIRT025925), hsa-mir-128-3p (MIRT022103)

    Block miRNA regulation of human, mouse, rat CTDSP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTDSP1 (see all 21):
    hsa-miR-148b* hsa-miR-1271 hsa-miR-486-3p hsa-miR-500a hsa-miR-888* hsa-miR-124 hsa-miR-501-5p hsa-miR-296-5p
    SwitchGear 3'UTR luciferase reporter plasmidCTDSP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CTDSP1

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    GenScript: all cDNA clones in your preferred vector (see all 4): CTDSP1 (NM_021198)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTDSP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDSP1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTDS1_HUMAN, Q9GZU7: Nucleus. Note=Colocalizes with RNA polymerase II
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10967134

    Find genes that share ontologies with CTDSP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTDSP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by BMP
    BMP receptor signaling0.31
    2Regulation of cytoplasmic and nuclear SMAD2/3 signaling
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling
    3Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity


    3 BioSystems Pathways for CTDSP1
        BMP receptor signaling
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling
    Coregulation of Androgen receptor activity


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTDSP1
    Interactions:

        Search GeneGlobe Interaction Network for CTDSP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTDSP1 (Q9GZU71, 2, 3 ENSP000002730624) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDCA3Q996182, 3, ENSP000002292654MINT-68177 I2D: score=5 STRING: ENSP00000229265
    LDB1Q86U703, ENSP000003924664I2D: score=1 STRING: ENSP00000392466
    GTF2F1P352693, ENSP000003779694I2D: score=1 STRING: ENSP00000377969
    MBPP026863, ENSP000003482734I2D: score=1 STRING: ENSP00000348273
    POLR2AP249283, ENSP000003149494I2D: score=2 STRING: ENSP00000314949
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA12721286
    GO:0006470protein dephosphorylation IDA12721286
    GO:0045665negative regulation of neuron differentiation IEA--
    GO:0050768negative regulation of neurogenesis IEA--

    Find genes that share ontologies with CTDSP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTDSP1 (CTDS1)

    3 HMDB Compounds for CTDSP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 DrugBank Compounds for CTDSP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aspartate Beryllium Trifluoride-- --target--17139284 17016423 10592235
    Citric Acid-- 77-92-9target--17139284 17016423 10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTDSP1 gene (4 alternative transcripts): 
    NM_001206878.1  NM_021198.2  NM_182642.2  NM_001206879.1  

    Unigene Cluster for CTDSP1:

    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
    Hs.444468  [show with all ESTs]
    Unigene Representative Sequence: AF229162
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491064 ENST00000443891 ENST00000492545 ENST00000473420 ENST00000498160
    ENST00000273062(uc021vwv.1 uc002vhx.3 uc002vhy.3 uc002vhz.3)
    ENST00000497677 ENST00000494067 ENST00000452977 ENST00000428361 ENST00000496785
    ENST00000431127 ENST00000488627 ENST00000482272 ENST00000464255
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CTDSP1 (see all 21):
    hsa-miR-148b* hsa-miR-1271 hsa-miR-486-3p hsa-miR-500a hsa-miR-888* hsa-miR-124 hsa-miR-501-5p hsa-miR-296-5p
    SwitchGear 3'UTR luciferase reporter plasmidCTDSP1 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 4): CTDSP1 (NM_021198)
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      QuantiFast Probe-based Assays in human, mouse, rat CTDSP1

    Additional mRNA sequence: 

    AF217969.1 AF229162.1 AF258582.1 AK075090.1 AY279529.1 AY279530.1 BC012977.2 

    18 DOTS entries:

    DT.115679  DT.100811863  DT.100772643  DT.100811866  DT.40262275  DT.95332856  DT.101954918  DT.95083331 
    DT.75155544  DT.92459251  DT.95083330  DT.100811865  DT.91867513  DT.95083318  DT.95083319  DT.95315128 
    DT.97862167  DT.99956245 

    Selected AceView cDNA sequences (see all 326):

    AA566001 AF217969 BM820305 BM684398 AF229162 BM975639 AA687750 BM771982 
    CA502813 BI908384 BM562147 AA970842 AW673969 AL524545 BQ941801 AI285191 
    AI184352 AW574683 BX437591 CR590321 AI283397 BM704641 CA311121 BE018086 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CTDSP1 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e
    SP1:              -     -     -     -     -     -     -     -                       -                                                         
    SP2:                                            -     -     -                       -                                                         
    SP3:                                            -     -     -                       -                                                         
    SP4:                                                        -                       -                                                         
    SP5:                          -     -     -     -     -     -                       -                                                         


    ECgene alternative splicing isoforms for CTDSP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTDSP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGATTCCGG
    CTDSP1 Expression
    About this image

    CTDSP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTDSP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444468

    UniProtKB/Swiss-Prot: CTDS1_HUMAN, Q9GZU7
    Tissue specificity: Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle,
    spleen, lung and placenta

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDSP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CTDSP1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctdsp11 , 5 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more1, 5 92.34(n)1
    98.85(a)1
      1 (38.54 cM)5
    2272921  NM_153088.21  NP_694728.11 
     743915095 
    chicken
    (Gallus gallus)
    Aves CTDSP11 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more 79.83(n)
    81.97(a)
      100857754  XM_003641649.2  XP_003641697.2 
    lizard
    (Anolis carolinensis)
    Reptilia CTDSP16
    CTD (carboxy-terminal domain, RNA polymerase II, p...
    78(a)
    1 ↔ 1
    1(88577991-88614643)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ctdsp11 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more 73.46(n)
    76.54(a)
      100380164  XM_002933936.2  XP_002933982.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ctdsp16
    CTD (carboxy-terminal domain, RNA polymerase II, p...
    75(a)
    1 ↔ 1
    9(42763196-42814463) ENSDARG00000040674
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58301 CG5830 60.64(n)
    63.45(a)
      39748  NM_140568.2  NP_648825.1 
    worm
    (Caenorhabditis elegans)
    Secernentea scpl-11 scpl-1 57.29(n)
    63.2(a)
      181944  NM_170917.4  NP_740911.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PSR26
    PSR16
    Functionally redundant Psr1p homolog, a plasma mem...
    Plasma membrane associated protein phosphatase inv...
    29(a)
    26(a)
    many ↔ many
    many ↔ many
    XII(180288-181481) YLR019W
    XII(129330-130613) YLL010C


    ENSEMBL Gene Tree for CTDSP1 (if available)
    TreeFam Gene Tree for CTDSP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTDSP1 gene
    CTDSPL22  CTDSPL2  CTDSP22  
    4 SIMAP similar genes for CTDSP1 using alignment to 4 protein entries:     CTDS1_HUMAN (see all proteins):
    CTDSPL    CTDSP2    CTDSPL2    CTDNEP1

    Find genes that share paralogs with CTDSP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTDSP1 (see all 248)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1123513491,2
    C,F--218647321(+) CCAAGT/AGCCCA 3 -- us2k1 int12Minor allele frequency- A:0.03NA 122
    rs1151818951,2
    C,F--218647364(+) TGAGGG/ACCTCT 3 -- us2k1 int13Minor allele frequency- A:0.10WA NA EA 358
    rs1870807601,2
    --218647412(+) GCGTGA/CGGCGC 3 -- us2k1 int10--------
    rs27390481,2
    C,H--218647490(+) GGCCGG/TCGACC 3 -- us2k1 int110Minor allele frequency- T:0.03NA CSA WA EA 370
    rs1121520871,2
    F--218647534(+) GAGAAG/AGTGGC 3 -- us2k1 int11Minor allele frequency- A:0.50CSA 2
    rs1143545091,2
    F--218647605(+) GGCGGG/CAACGC 3 -- us2k1 int11Minor allele frequency- C:0.02WA 118
    rs1815112531,2
    --218647680(+) CAGGGC/GGCTTT 3 -- us2k1 int10--------
    rs27390491,2
    C,F,H--218647805(+) GTTTCA/GGGCCA 3 -- us2k1 int122Minor allele frequency- G:0.48NS EA NA CSA WA 2347
    rs1411079641,2
    --218647927(+) AGGAAA/CCCGAG 3 -- us2k1 int10--------
    rs1159423601,2
    C,F--218648031(+) TGGCCG/TAGGGC 3 -- us2k1 int12Minor allele frequency- T:0.15WA EA 238

    HapMap Linkage Disequilibrium report for CTDSP1 (219262979 - 219270664 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CTDSP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3166CNV Insertion18451855
    nsv519829CNV Loss19592680
    dgv4435n71CNV Loss21882294
    nsv875860CNV Loss21882294
    nsv875855CNV Loss21882294
    nsv875858CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTDSP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CTDSP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605323    OMIM disorders: --


    Find genes that share disorders with CTDSP1           About GenesLikeMe

    Genetic Association Database (GAD): CTDSP1
    Human Genome Epidemiology (HuGE) Navigator: CTDSP1 (3 documents)

    Export disorders for CTDSP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTDSP1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with CTDSP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. (PubMed id 12721286)1, 2, 3, 9 Yeo M.... Gill G.N. (J. Biol. Chem. 2003)
    2. Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35. (PubMed id 10967134)1, 2, 9 Marquet S.... Schurr E. (Mamm. Genome 2000)
    3. Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility. (PubMed id 11950066)1, 3, 9 Ma X....Graviss E. (J. Hum. Genet. 2002)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Small CTD phosphatases function in silencing neuronal gene expression. (PubMed id 15681389)1, 2 Yeo M.... Gill G.N. (Science 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Determinants for dephosphorylation of the RNA polymerase II C- terminal domain by Scp1. (PubMed id 17157258)2, 9 Zhang Y.... Noel J.P. (Mol. Cell 2006)
    8. Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous system. (PubMed id 14743429)1, 9 Fernandes A.O....Campagnoni A.T. (J. Neurosci. Res. 2004)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58190 HGNC: 21614 AceView: CTDSP1 Ensembl:ENSG00000144579 euGenes: HUgn58190
    ECgene: CTDSP1 H-InvDB: CTDSP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CTDSP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CTDSP1 gene:
    Search GeneIP for patents involving CTDSP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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