Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CTDSP1 Gene

Aliases for CTDSP1 Gene

  • CTD Small Phosphatase 1 2 3 5
  • CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 2 3
  • Nuclear LIM Interactor-Interacting Factor 3 3 4
  • Small C-Terminal Domain Phosphatase 1 3 4
  • NLI-Interacting Factor 3 3 4
  • Small CTD Phosphatase 1 2 4
  • EC 3.1.3.16 4 61
  • NLI-IF 3 4
  • NLIIF 3 4
  • NIF3 3 4
  • SCP1 3 4
  • Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 1 3
  • Nuclear LIM Interactor-Interacting Factor 2

External Ids for CTDSP1 Gene

Previous GeneCards Identifiers for CTDSP1 Gene

  • GC02P219467
  • GC02P219091
  • GC02P218972
  • GC02P219262
  • GC02P211117

Summaries for CTDSP1 Gene

Entrez Gene Summary for CTDSP1 Gene

  • This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for CTDSP1 Gene

CTDSP1 (CTD Small Phosphatase 1) is a Protein Coding gene. Among its related pathways are Regulation of cytoplasmic and nuclear SMAD2/3 signaling and Signaling by BMP. GO annotations related to this gene include phosphatase activity and CTD phosphatase activity. An important paralog of this gene is CTDSPL.

UniProtKB/Swiss-Prot for CTDSP1 Gene

  • Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

Gene Wiki entry for CTDSP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTDSP1 Gene

Genomics for CTDSP1 Gene

Regulatory Elements for CTDSP1 Gene

Enhancers for CTDSP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F218281 1.5 FANTOM5 ENCODE 12 -108.0 -108018 17.9 HDGF PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ENSG00000261338 SLC11A1 RNF25 CNOT9 CTDSP1 MIR26B STK36 AAMP ARPC2 TMBIM1
GH02F218301 1.3 Ensembl ENCODE 12 -96.7 -96668 0.9 ATF1 ARNT ZFP64 ARID4B DMAP1 ZNF48 ZNF2 GTF3C2 ZNF121 SLC30A9 AAMP PNKD CNOT9 NHEJ1 SLC11A1 CTDSP1 MIR26B USP37 SLC23A3 BCS1L
GH02F218145 0.9 FANTOM5 4.5 -252.9 -252931 0.3 GATAD2A CTCF ZNF263 NFIA FOXA3 CEBPB CEBPG HMG20A MIER3 KLF16 CXCR2 CXCR1 ENSG00000261338 TNS1 SLC11A1 CTDSP1 ARPC2 GC02P218136
GH02F218156 0.5 FANTOM5 3.8 -242.0 -241975 0.3 CTCF CEBPB CXCR1 CXCR2 ENSG00000261338 CTDSP1 SLC11A1 ARPC2 GC02P218136
GH02F218381 1.3 Ensembl ENCODE 0.4 -14.9 -14853 4.0 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TMBIM1 MIR6513 AAMP PNKD SLC11A1 CATIP CTDSP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CTDSP1 on UCSC Golden Path with GeneCards custom track

Promoters for CTDSP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001551843 244 6201 HDGF CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for CTDSP1 Gene

Chromosome:
2
Start:
218,398,256 bp from pter
End:
218,405,941 bp from pter
Size:
7,686 bases
Orientation:
Plus strand

Genomic View for CTDSP1 Gene

Genes around CTDSP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTDSP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTDSP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTDSP1 Gene

Proteins for CTDSP1 Gene

  • Protein details for CTDSP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZU7-CTDS1_HUMAN
    Recommended name:
    Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
    Protein Accession:
    Q9GZU7
    Secondary Accessions:
    • C9IYG0
    • Q7Z5Q3
    • Q7Z5Q4

    Protein attributes for CTDSP1 Gene

    Size:
    261 amino acids
    Molecular mass:
    29203 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer (By similarity). Interacts with GTF2F1. Interacts with REST.
    SequenceCaution:
    • Sequence=AAP34398.1; Type=Frameshift; Positions=72; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CTDSP1 Gene

    Alternative splice isoforms for CTDSP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTDSP1 Gene

Selected DME Specific Peptides for CTDSP1 Gene

Q9GZU7:
  • DNSPASY
  • HQVYVLKRP
  • GNYVKDL
  • DLDETLVHSSFK
  • FTASLAKYADPV

Post-translational modifications for CTDSP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for CTDSP1 Gene

Gene Families for CTDSP1 Gene

Protein Domains for CTDSP1 Gene

Suggested Antigen Peptide Sequences for CTDSP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZU7

UniProtKB/Swiss-Prot:

CTDS1_HUMAN :
  • Contains 1 FCP1 homology domain.
Domain:
  • Contains 1 FCP1 homology domain.
genes like me logo Genes that share domains with CTDSP1: view

Function for CTDSP1 Gene

Molecular function for CTDSP1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 5. {ECO:0000269 PubMed:12721286};
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Stimulated by GTF2F1. Inhibited by beryllofluoride anions.
UniProtKB/Swiss-Prot Function:
Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

Enzyme Numbers (IUBMB) for CTDSP1 Gene

Gene Ontology (GO) - Molecular Function for CTDSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0005515 protein binding IPI 12721286
GO:0008420 CTD phosphatase activity IDA 12721286
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
genes like me logo Genes that share ontologies with CTDSP1: view
genes like me logo Genes that share phenotypes with CTDSP1: view

Animal Models for CTDSP1 Gene

MGI Knock Outs for CTDSP1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CTDSP1 Gene

Localization for CTDSP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTDSP1 Gene

Nucleus. Note=Colocalizes with RNA polymerase II.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTDSP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CTDSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10967134
GO:0005654 nucleoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CTDSP1: view

Pathways & Interactions for CTDSP1 Gene

genes like me logo Genes that share pathways with CTDSP1: view

SIGNOR curated interactions for CTDSP1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for CTDSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 12721286
GO:0006470 protein dephosphorylation IDA 12721286
GO:0016311 dephosphorylation IEA --
GO:0045665 negative regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with CTDSP1: view

Drugs & Compounds for CTDSP1 Gene

(5) Drugs for CTDSP1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Aspartate Beryllium Trifluoride Experimental Pharma Target 0
Citric Acid Vet_approved Nutra Agonist, Activator, Target 1106
calcium Nutra 0

(1) Additional Compounds for CTDSP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with CTDSP1: view

Transcripts for CTDSP1 Gene

Unigene Clusters for CTDSP1 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTDSP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e
SP1: - - - - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - -
SP6:
SP7: - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - -
SP11: -

Relevant External Links for CTDSP1 Gene

GeneLoc Exon Structure for
CTDSP1
ECgene alternative splicing isoforms for
CTDSP1

Expression for CTDSP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CTDSP1 Gene

mRNA differential expression in normal tissues according to GTEx for CTDSP1 Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for CTDSP1 Gene

This gene is overexpressed in NK cells (22.2), Bone (15.5), and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTDSP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CTDSP1 Gene:

CTDSP1

SOURCE GeneReport for Unigene cluster for CTDSP1 Gene:

Hs.444468

mRNA Expression by UniProt/SwissProt for CTDSP1 Gene:

Q9GZU7-CTDS1_HUMAN
Tissue specificity: Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.
genes like me logo Genes that share expression patterns with CTDSP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for CTDSP1 Gene

Orthologs for CTDSP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTDSP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTDSP1 34 35
  • 99.62 (n)
mouse
(Mus musculus)
Mammalia Ctdsp1 34 16 35
  • 92.34 (n)
dog
(Canis familiaris)
Mammalia CTDSP1 34 35
  • 91.95 (n)
cow
(Bos Taurus)
Mammalia CTDSP1 34 35
  • 91.41 (n)
rat
(Rattus norvegicus)
Mammalia Ctdsp1 34
  • 90.8 (n)
oppossum
(Monodelphis domestica)
Mammalia CTDSP1 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 16 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CTDSP1 34 35
  • 79.83 (n)
lizard
(Anolis carolinensis)
Reptilia CTDSP1 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctdsp1 34
  • 73.46 (n)
zebrafish
(Danio rerio)
Actinopterygii ctdsp1 35
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011422 34
  • 65.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5830 34 35
  • 60.64 (n)
worm
(Caenorhabditis elegans)
Secernentea scpl-1 34 35
  • 57.29 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSR2 35
  • 29 (a)
ManyToMany
PSR1 35
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 75 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU08380 34
  • 55.22 (n)
Species where no ortholog for CTDSP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTDSP1 Gene

ENSEMBL:
Gene Tree for CTDSP1 (if available)
TreeFam:
Gene Tree for CTDSP1 (if available)

Paralogs for CTDSP1 Gene

Paralogs for CTDSP1 Gene

(4) SIMAP similar genes for CTDSP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CTDSP1: view

Variants for CTDSP1 Gene

Sequence variations from dbSNP and Humsavar for CTDSP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10189062 -- 218,397,815(+) CAGGC(A/G)TGGGG upstream-variant-2KB
rs1046052 -- 218,405,684(+) TGTTT(C/T)TGAAG utr-variant-3-prime
rs1057651 -- 218,403,769(+) GAATA(A/G)AAAAT intron-variant, utr-variant-3-prime
rs111377494 -- 218,397,585(+) GAATC(C/T)CGTTC upstream-variant-2KB
rs111615340 -- 218,399,070(+) GCCGT(A/C)GACCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CTDSP1 Gene

Variant ID Type Subtype PubMed ID
nsv519829 CNV loss 19592680
nsv3166 CNV insertion 18451855
nsv1073011 CNV deletion 25765185

Variation tolerance for CTDSP1 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTDSP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTDSP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTDSP1 Gene

Disorders for CTDSP1 Gene

Relevant External Links for CTDSP1

Genetic Association Database (GAD)
CTDSP1
Human Genome Epidemiology (HuGE) Navigator
CTDSP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTDSP1

No disorders were found for CTDSP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTDSP1 Gene

Publications for CTDSP1 Gene

  1. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. (PMID: 12721286) Yeo M. … Gill G.N. (J. Biol. Chem. 2003) 2 3 4 22 64
  2. Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility. (PMID: 11950066) Ma X. … Graviss E. (J. Hum. Genet. 2002) 2 3 22 64
  3. Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35. (PMID: 10967134) Marquet S. … Schurr E. (Mamm. Genome 2000) 3 4 22 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Determinants for dephosphorylation of the RNA polymerase II C- terminal domain by Scp1. (PMID: 17157258) Zhang Y. … Noel J.P. (Mol. Cell 2006) 4 22 64

Products for CTDSP1 Gene

Sources for CTDSP1 Gene

Content
Loading form....