Aliases for CTDSP1 Gene
External Ids for CTDSP1 Gene
Previous GeneCards Identifiers for CTDSP1 Gene
This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for CTDSP1 Gene
CTDSP1 (CTD Small Phosphatase 1) is a Protein Coding gene. Among its related pathways are Regulation of cytoplasmic and nuclear SMAD2/3 signaling and Signaling by BMP. GO annotations related to this gene include phosphatase activity and CTD phosphatase activity. An important paralog of this gene is CTDSPL.
UniProtKB/Swiss-Prot for CTDSP1 Gene
Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.