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Aliases for CTDSP1 Gene

Aliases for CTDSP1 Gene

  • CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1 2 3
  • NLIIF 3 4 6
  • SCP1 3 4 6
  • Nuclear LIM Interactor-Interacting Factor 3 3 4
  • Small C-Terminal Domain Phosphatase 1 3 4
  • NLI-Interacting Factor 3 3 4
  • Small CTD Phosphatase 1 2 4
  • EC 3.1.3.16 4 64
  • NLI-IF 3 4
  • NIF3 3 4
  • Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 1 3
  • Nuclear LIM Interactor-Interacting Factor 2

External Ids for CTDSP1 Gene

Summaries for CTDSP1 Gene

Entrez Gene Summary for CTDSP1 Gene

  • This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for CTDSP1 Gene

CTDSP1 (CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 1) is a Protein Coding gene. Among its related pathways are Coregulation of Androgen receptor activity and Signaling by BMP. GO annotations related to this gene include CTD phosphatase activity. An important paralog of this gene is CTDSPL.

UniProtKB/Swiss-Prot for CTDSP1 Gene

  • Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

Gene Wiki entry for CTDSP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTDSP1 Gene

Genomics for CTDSP1 Gene

Genomic Location for CTDSP1 Gene

Start:
218,398,256 bp from pter
End:
218,405,941 bp from pter
Size:
7,686 bases
Orientation:
Plus strand

Genomic View for CTDSP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTDSP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTDSP1 Gene

Regulatory Elements for CTDSP1 Gene

Proteins for CTDSP1 Gene

  • Protein details for CTDSP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZU7-CTDS1_HUMAN
    Recommended name:
    Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
    Protein Accession:
    Q9GZU7
    Secondary Accessions:
    • C9IYG0
    • Q7Z5Q3
    • Q7Z5Q4

    Protein attributes for CTDSP1 Gene

    Size:
    261 amino acids
    Molecular mass:
    29203 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per monomer.;
    Quaternary structure:
    • Monomer (By similarity). Interacts with GTF2F1. Interacts with REST.
    SequenceCaution:
    • Sequence=AAP34398.1; Type=Frameshift; Positions=72; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CTDSP1 Gene

    Alternative splice isoforms for CTDSP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CTDSP1 Gene

Proteomics data for CTDSP1 Gene at MOPED

Selected DME Specific Peptides for CTDSP1 Gene

Post-translational modifications for CTDSP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTDSP1 Gene

Domains for CTDSP1 Gene

Gene Families for CTDSP1 Gene

HGNC:
  • CTD :Serine/threonine phosphatases / CTD aspartate-based phosphatases

Protein Domains for CTDSP1 Gene

UniProtKB/Swiss-Prot:

CTDS1_HUMAN
Domain:
  • Contains 1 FCP1 homology domain.:
    • Q9GZU7
genes like me logo Genes that share domains with CTDSP1: view

Function for CTDSP1 Gene

Molecular function for CTDSP1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 5. {ECO:0000269 PubMed:12721286};
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Stimulated by GTF2F1. Inhibited by beryllofluoride anions.
UniProtKB/Swiss-Prot Function: Preferentially catalyzes the dephosphorylation of Ser-5 within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

Enzyme Numbers (IUBMB) for CTDSP1 Gene

Gene Ontology (GO) - Molecular Function for CTDSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12721286
GO:0008420 CTD phosphatase activity IDA 12721286
GO:0016791 phosphatase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CTDSP1: view

miRNA for CTDSP1 Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CTDSP1 Gene

Localization for CTDSP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTDSP1 Gene

Nucleus. Note=Colocalizes with RNA polymerase II.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTDSP1 Gene COMPARTMENTS Subcellular localization image for CTDSP1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CTDSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10967134
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CTDSP1: view

Pathways for CTDSP1 Gene

genes like me logo Genes that share pathways with CTDSP1: view

Gene Ontology (GO) - Biological Process for CTDSP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 12721286
GO:0006470 protein dephosphorylation IDA 12721286
GO:0045665 negative regulation of neuron differentiation IEA --
GO:0050768 negative regulation of neurogenesis --
genes like me logo Genes that share ontologies with CTDSP1: view

Compounds for CTDSP1 Gene

(3) HMDB Compounds for CTDSP1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5

(2) Drugbank Compounds for CTDSP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aspartate Beryllium Trifluoride
target
Citric Acid
77-92-9 target
genes like me logo Genes that share compounds with CTDSP1: view

Transcripts for CTDSP1 Gene

Unigene Clusters for CTDSP1 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTDSP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e
SP1: - - - - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - -
SP6:
SP7: - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10: - -
SP11: -

Relevant External Links for CTDSP1 Gene

GeneLoc Exon Structure for
CTDSP1
ECgene alternative splicing isoforms for
CTDSP1

Expression for CTDSP1 Gene

mRNA expression in normal human tissues for CTDSP1 Gene

mRNA differential expression in normal tissues according to GTEx for CTDSP1 Gene

This gene is overexpressed in Whole Blood (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTDSP1 Gene

SOURCE GeneReport for Unigene cluster for CTDSP1 Gene Hs.444468

mRNA Expression by UniProt/SwissProt for CTDSP1 Gene

Q9GZU7-CTDS1_HUMAN
Tissue specificity: Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.
genes like me logo Genes that share expressions with CTDSP1: view

Orthologs for CTDSP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTDSP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTDSP1 36
  • 99.62 (n)
  • 99.62 (a)
CTDSP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTDSP1 36
  • 91.41 (n)
  • 98.85 (a)
CTDSP1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTDSP1 36
  • 91.95 (n)
  • 98.47 (a)
CTDSP1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctdsp1 36
  • 92.34 (n)
  • 98.85 (a)
Ctdsp1 16
Ctdsp1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTDSP1 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 16 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ctdsp1 36
  • 90.8 (n)
  • 98.47 (a)
chicken
(Gallus gallus)
Aves CTDSP1 36
  • 79.83 (n)
  • 81.97 (a)
CTDSP1 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTDSP1 37
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctdsp1 36
  • 73.46 (n)
  • 76.54 (a)
zebrafish
(Danio rerio)
Actinopterygii ctdsp1 37
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011422 36
  • 65.28 (n)
  • 71.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5830 36
  • 60.64 (n)
  • 63.45 (a)
CG5830 37
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea scpl-1 36
  • 57.29 (n)
  • 63.2 (a)
scpl-1 37
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSR1 37
  • 26 (a)
ManyToMany
PSR2 37
  • 29 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU08380 36
  • 55.22 (n)
  • 54.73 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 75 (a)
OneToMany
Species with no ortholog for CTDSP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTDSP1 Gene

ENSEMBL:
Gene Tree for CTDSP1 (if available)
TreeFam:
Gene Tree for CTDSP1 (if available)

Paralogs for CTDSP1 Gene

Paralogs for CTDSP1 Gene

Selected SIMAP similar genes for CTDSP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CTDSP1: view

Variants for CTDSP1 Gene

Sequence variations from dbSNP and Humsavar for CTDSP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs13015 -- 218,405,602(-) GTTGG(A/C)ACAGG utr-variant-3-prime
rs1046052 -- 218,405,684(+) TGTTT(C/T)TGAAG utr-variant-3-prime
rs1057651 -- 218,403,769(+) GAATA(A/G)AAAAT intron-variant
rs1809231 -- 218,397,456(-) GTGCA(C/G)AAAGT upstream-variant-2KB
rs2227259 -- 218,403,234(+) CAGTA(C/T)GCAGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CTDSP1 Gene

Variant ID Type Subtype PubMed ID
nsv519829 CNV Loss 19592680
nsv875855 CNV Loss 21882294
nsv3166 CNV Insertion 18451855
dgv4435n71 CNV Loss 21882294
nsv875858 CNV Loss 21882294
nsv875860 CNV Loss 21882294

Relevant External Links for CTDSP1 Gene

HapMap Linkage Disequilibrium report
CTDSP1

Disorders for CTDSP1 Gene

Relevant External Links for CTDSP1

Genetic Association Database (GAD)
CTDSP1
Human Genome Epidemiology (HuGE) Navigator
CTDSP1
genes like me logo Genes that share disorders with CTDSP1: view

No data available for UniProtKB/Swiss-Prot for CTDSP1 Gene

Publications for CTDSP1 Gene

  1. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. (PMID: 12721286) Yeo M. … Gill G.N. (J. Biol. Chem. 2003) 2 3 4 23
  2. Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35. (PMID: 10967134) Marquet S. … Schurr E. (Mamm. Genome 2000) 3 4 23
  3. Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility. (PMID: 11950066) Ma X. … Graviss E. (J. Hum. Genet. 2002) 2 3 23
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  5. Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous system. (PMID: 14743429) Fernandes A.O. … Campagnoni A.T. (J. Neurosci. Res. 2004) 3 23

Products for CTDSP1 Gene

Sources for CTDSP1 Gene

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