Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CTDP1 Gene

protein-coding GIFtS: 62
GCID: GC18P077494

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide...

Explore 7 diseases affiliated with
CTDP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Phosphatase, Subunit 1¹ ²		Serine Phosphatase FCP1a²
FCP1¹ ² ³ ⁵		TFIIF-Associating CTD Phosphatase 1²
CCFDN² ⁵		Transcription Factor IIF-Associating CTD Phosphatase 1²
CTD Of POLR2A, Phosphatase Of, Subunit 1²		EC 3.1.3.16³
RNA Polymerase II Subunit A C-Terminal Domain Phosphatase²		TFIIF-Associating CTD Phosphatase³

External Ids:	HGNC: 2498¹	Entrez Gene: 9150²	Ensembl: ENSG00000060069⁷	OMIM: 604927⁵	UniProtKB: Q9Y5B0³

Export aliases for CTDP1 gene to outside databases

Previous GC identifers: GC18P076954 GC18P077174 GC18P075538 GC18P075540 GC18P074064

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CTDP1:

This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation

factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of

RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with

congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants

encoding different isoforms have been described for this gene. (provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: CTDP1_HUMAN, Q9Y5B0

Function: Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of

the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from

mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for

M-phase-promoting factor (MPF)/CDK1 inactivation

Gene Wiki entry for CTDP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_025028.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CTDP1 gene promoter:
ER-alpha AhR USF1 Pax-5 c-Ets-1 Roaz Arnt HEN1 AREB6 USF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CTDP1 promoter sequence

Search SABiosciences Chromatin IP Primers for CTDP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTDP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q23 Ensembl cytogenetic band: 18q23 HGNC cytogenetic band: 18q23

CTDP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTDP1 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P077494: view genomic region (about GC identifiers)

Start:	77,439,801 bp from pter	End:	77,514,510 bp from pter
Size:	74,710 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CTDP1_HUMAN, Q9Y5B0 (See protein sequence)

Recommended Name: RNA polymerase II subunit A C-terminal domain phosphatase

Size: 961 amino acids; 104399 Da

Subunit: Homodimer. Interacts with GTF2F1. Interacts with WDR77, SNRPB and SNRNP70

Subcellular location: Nucleus. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm,

cytoskeleton, spindle pole. Midbody. Note=Found at centrosomes in prometaphase, at spindle and spindle poles in

metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively

3 PDB 3D structures from and Proteopedia for CTDP1:

1J2X (3D)

1ONV (3D)

2K7L (3D)

Secondary accessions: A8MY97 Q7Z644 Q96BZ1 Q9Y6F5

Alternative splicing: 4 isoforms: Q9Y5B0-1 Q9Y5B0-2 Q9Y5B0-3 Q9Y5B0-4

Explore the universe of human proteins at neXtProt for CTDP1: NX_Q9Y5B0

Post-translational modifications:

Phosphorylated. In the presence of TFIIF, the phosphorylated form has an increased CTD phosphatase activity. The

phosphorylation is required for the physical interaction with GTF2F1¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y5B0

CTDP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001189433.1 NP_004706.3 NP_430255.2

ENSEMBL proteins:

ENSP00000299543 ENSP00000075430 ENSP00000465119 ENSP00000467563

Reactome Protein details: Q9Y5B0
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CTDP1
	GenScript Custom Purified and Recombinant Proteins Services for CTDP1
	Novus Biologicals CTDP1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CTDP1

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	IDA	--
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--

CTDP1 for ontologies About GeneDecksing

CTDP1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CTDP1
	GenScript Custom Superior Antibodies Services for CTDP1
	Novus Biologicals CTDP1 Antibodies
	Abcam antibodies for CTDP1
	Uscn Antibodies for CTDP1
	ThermoFisher Antibodies for CTDP1

Assay Products for CTDP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CTDP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CTDP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CTDP1 for domains About GeneDecksing

5 InterPro domains/families:

IPR011947 FCP1_euk

IPR023214 HAD-like_dom

IPR015388 FCP1_C

IPR004274 NIF

IPR001357 BRCT_dom

Graphical View of Domain Structure for InterPro Entry Q9Y5B0

ProtoNet protein and cluster: Q9Y5B0

2 Blocks protein families:

IPB001357 BRCT domain

IPB004274 NLI interacting factor

UniProtKB/Swiss-Prot: CTDP1_HUMAN, Q9Y5B0

Similarity: Contains 1 BRCT domain

Similarity: Contains 1 FCP1 homology domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CTDP1_HUMAN, Q9Y5B0

Function: Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of

the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from

mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for

M-phase-promoting factor (MPF)/CDK1 inactivation

Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

Enzyme Number (IUBMB): EC 3.1.3.16¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CTDP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTDP1
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CTDP1 (see all 17):
		hsa-miR-548am hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-499-3p hsa-miR-411 hsa-miR-1271 hsa-miR-138-2* hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: CTDP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTDP1 (see all 7) OriGene shRNA RFP: CTDP1 OriGene siRNA: CTDP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTDP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CTDP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTDP1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTDP1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CTDP1 (NM_001202504)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTDP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CTDP1
		Search LifeMap BioReagents cell lines for CTDP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDP1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003899	DNA-directed RNA polymerase activity	TAS	9765293
GO:0005515	protein binding	--	--
GO:0008420	CTD phosphatase activity	IDA	12721286

CTDP1 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for CTDP1:

Decreased POU5F1-GFP protein e

Decreased p24 protein expressi

Increased circadian period len

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of RNA Pol II elongation complex

8/16 pathways (see all 16)
RNA Polymerase II Transcription Elongation	1.00	HIV-1 elongation arrest and recovery	0.74
Formation of HIV-1 elongation complex in the absence of HIV-1 Tat	1.00	Pausing and recovery of HIV-1 elongation	0.74
Formation of RNA Pol II elongation complex	1.00	Elongation arrest and recovery	0.74
Formation of HIV-1 elongation complex containing HIV-1 Tat	0.98	RNA Polymerase II Pre-transcription Events	0.72

Late Phase of HIV Life Cycle

Late Phase of HIV Life Cycle

1.00

HIV Life Cycle

0.90

Transcription

Transcription

1.00

RNA Polymerase II Transcription

0.69

HIV Infection

HIV Infection

1.00

Disease

Disease

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/23 Reactome Pathways for CTDP1 (see all 23)

	Formation of RNA Pol II elongation complex
	Pausing and recovery of Tat-mediated HIV-1 elongation
	Tat-mediated HIV-1 elongation arrest and recovery
	Tat-mediated elongation of the HIV-1 transcript
	Late Phase of HIV Life Cycle

CTDP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CTDP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/91 Interacting proteins for CTDP1 (Q9Y5B0^{2, 3} ENSP00000299543⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 91)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=1 STRING: ENSP00000352980
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006366	transcription from RNA polymerase II promoter	TAS	--
GO:0006368	transcription elongation from RNA polymerase II promoter	TAS	--
GO:0006470	protein dephosphorylation	IDA	--
GO:0007067	mitosis	IEA	--
GO:0010458	exit from mitosis	IMP	--

CTDP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CTDP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CTDP1

3 HMDB Compounds for CTDP1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Phosphate	NFB Orthophosphate (see all 13)	14265-44-2	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

2 Novoseek chemical compound relationships for CTDP1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	26.6	3	15723518 (1), 16939648 (1), 12351650 (1)
threonine	20.2	2	15723518 (2)

Search CenterWatch for drugs/clinical trials and news about CTDP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CTDP1 gene (3 alternative transcripts):

NM_001202504.1 NM_004715.4 NM_048368.3

Unigene Cluster for CTDP1:

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

Hs.465490 [show with all ESTs]

Unigene Representative Sequence: NM_004715

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000299543(uc002lnh.2 uc002lni.2 uc010drd.2 uc021ult.1)

ENST00000075430 ENST00000591598 ENST00000590635 ENST00000587623 ENST00000590599

ENST00000585951

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CTDP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTDP1
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate CTDP1 (see all 17):
		hsa-miR-548am hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-499-3p hsa-miR-411 hsa-miR-1271 hsa-miR-138-2* hsa-miR-9

		SwitchGear 3'UTR luciferase reporter plasmid: CTDP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTDP1 (see all 7) OriGene shRNA RFP: CTDP1 OriGene siRNA: CTDP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTDP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTDP1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTDP1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CTDP1 (NM_001202504)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTDP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTDP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CTDP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTDP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTDP1

Additional cDNA sequence:

AF081287.1 AF154115.1 AK123180.1 BC015010.1 BC032515.1 BC047999.1 BC052576.1 BC063447.1

10 DOTS entries:

DT.97799180 DT.95159868 DT.95363116 DT.99973672 DT.100784054 DT.100784053 DT.121091640 DT.95077512

DT.95108466 DT.95144042

24/122 AceView cDNA sequences (see all 122):

BU857066 BM873335 BC052576 AA906696 CK300775 AI093288 BQ352227 AW009110

BQ014320 CR602644 BQ709073 BI793020 BQ082167 AW129505 AW444978 BC032515

BQ708848 CB123966 BM984547 BI792919 BE887531 CO249597 AA974914 AK123180

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CTDP1 (see all 9) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	·	14c	·	14d
SP1:
SP2:
SP3:																																			-		-		-
SP4:																																							-
SP5:																																							-

ECgene alternative splicing isoforms for CTDP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CTDP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See CTDP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTDP1

SOURCE GeneReport for Unigene cluster: Hs.465490

UniProtKB/Swiss-Prot: CTDP1_HUMAN, Q9Y5B0

Tissue specificity: Ubiquitously expressed. Isoform 3 is expressed in heart, brain, placenta, lung, liver, skeletal

muscle, kidney and placenta

SABiosciences Custom PCR Arrays for CTDP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTDP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CTDP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTDP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTDP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CTDP1 gene from 9/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ctdp1^{1 , 5}	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more^{1, 5}	79.01(n)¹ 79.89(a)¹		18 (53.48 cM)⁵ 67655¹ NM_026295.2¹ NP_080571.2¹ 80407959⁵
chicken (Gallus gallus)	Aves	CTDP1¹	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide more	67.23(n) 71.27(a)		420813 XM_418905.3 XP_418905.3
lizard (Anolis carolinensis)	Reptilia	CTDP1⁶	--	65(a)	1 ↔ 1	4(52783718-52828842)
African clawed frog (Xenopus laevis)	Amphibia	AF348120.1²	--	73.65(n)		AF348120.1
zebrafish (Danio rerio)	Actinopterygii	BM957098.1²	--	73.9(n)		BM957098.1
fruit fly (Drosophila melanogaster)	Insecta	CG12252³ Fcp1¹	CTD phosphatase³ CG12252-PA¹	35(a)³ 50.22(n)¹ 41.75(a)¹		60D5³ 37925¹ NM_138090.1¹ NP_611934.1¹
worm (Caenorhabditis elegans)	Secernentea	F36F2.6³ fcp-1¹	Protein FCP-1¹	39(a)³ 46.73(n)¹ 42.11(a)¹		I(9013061-9016767)³ 172719¹ NM_060022.3¹ NP_492423.2¹
thale cress (Arabidopsis thaliana)	eudicotyledons	CPL4¹	RNA polymerase II C-terminal domain phosphatase-like more	42.25(n) 29.67(a)		5008312 NM_001085295.1 NP_001078764.1
rice (Oryza sativa)	Liliopsida	Os05g0390500¹	hypothetical protein	43.9(n) 29.51(a)		4338679 NM_001061975.1 NP_001055440.1

ENSEMBL Gene Tree for CTDP1 (if available)
TreeFam Gene Tree for CTDP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111905286^1,2	C,	--	74063824(+)	`TAAAAT/GTTATA`	1	--	int¹		4	NA WA EA	360
rs113297720^1,2	C,	--	74063828(+)	`ATTTAT/CATACG`	1	--	int¹		4	NA WA EA	360
rs113432577^1,2	C,	--	74063832(+)	`ATATAC/TGTAAG`	1	--	int¹		4	NA WA EA	360
rs74898744^1,2	C,	--	74063854(+)	`ATAGTG/AAAAAA`	1	--	int¹		1	WA	2
rs77067725^1,2	C,F,	--	74064130(+)	`TTAATT/CCACGT`	1	--	int¹		4	NA CSA WA	242
rs75631874^1,2	C,	--	74064368(+)	`AGGTCG/CGAGGA`	1	--	int¹		3	NA WA	240
rs56006341^1,2	C,F,	--	74064973(+)	`ACCGAG/TAGGAA`	1	--	us2k¹		4	NA	126
rs79644263^1,2	C,	--	74065262(+)	`TCCGGG/CGCCTC`	1	--	us2k¹		1	NA	2
rs73972710^1,2	C,	--	74065453(+)	`AGGACC/GCCCGG`	1	--	us2k¹		2	WA	120
rs113762153^1,2	C,F,	--	74065490(+)	`CGCCCC/TTGGTG`	1	--	us2k¹		5	NA CSA WA EA	362

HapMap Linkage Disequilibrium report for CTDP1 (77439801 - 77514510 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for CTDP1
4 CNVs: 73228 102750 102749 73229
7 Indels: 26158 45714 42990 73227 26159 102748 61654
Human Gene Mutation Database (HGMD): CTDP1

Locus Specific Mutation Databases (LSDB): CTDP1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTDP1

DNA2.0 Custom Variant and Variant Library Synthesis for CTDP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CTDP1 for disorders           About GeneDecksing

OMIM gene information: 604927
OMIM disorders: 604168
UniProtKB/Swiss-Prot: CTDP1_HUMAN, Q9Y5B0

Defects in CTDP1 are a cause of congenital cataracts facial dysmorphism and neuropathy syndrome (CCFDN)

[MIM:604168]. CCFDN is an autosomal recessive developmental disorder that occurs in an endogamous group of Vlax Roma

(Gypsies). The syndrome is characterized by a complex clinical phenotype with seemingly unrelated features involving

multiple organs and systems. Developmental abnormalities include congenital cataracts and microcorneae,

hypomyelination of the peripheral nervous system, impaired physical growth, delayed early motor and intellectual

development, facial dysmorphism and hypogonadism. Central nervous system involvement, with cerebral and spinal cord

atrophy, may be the result of disrupted development with superimposed degenerative changes. Affected individuals are

prone to severe rhabdomyolysis after viral infections and to serious complications related to general anesthesia (such

as pulmonary edema and epileptic seizures)

7 diseases for CTDP1: About MalaCards

congenital cataracts, facial dysmorphism, and neuropathy congenital cataracts cataract neuropathy

pulmonary edema hypogonadism immunodeficiency

1 disease from the University of Copenhagen DISEASES database for CTDP1:

Neuropathy

Human Genome Epidemiology (HuGE) Navigator: CTDP1 (3 documents)

Export disorders for CTDP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CTDP1 gene, integrated from 9 sources (see all 67):
(articles sorted by number of sources associating them with CTDP1)

Utopia: connect your pdf to the dynamic
world of online information

FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO. (PubMed id 9765293)^{1, 2, 3} Archambault J....Greenblatt J. (1998)
The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation. (PubMed id 12591939)^{1, 2, 9} Friedl E.M.... Reinberg D. (2003)
Molecular mechanism of recruitment of TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF. (PubMed id 12591941)^{1, 2, 9} Kamada K.... Burley S.K. (2003)
The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP. (PubMed id 12560496)^{1, 2, 9} Licciardo P....Majello B. (2003)
Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit. (PubMed id 22692537)^{1, 2} Visconti R.... Grieco D. (2012)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Partial deficiency of the C-terminal-domain phosphatase of RNA polymerase II is associated with congenital cataracts facial dysmorphism neuropathy syndrome. (PubMed id 14517542)^{1, 2} Varon R.... Kalaydjieva L. (2003)
A protein phosphatase functions to recycle RNA polymerase II. (PubMed id 10385623)^{1, 2} Cho H.... Reinberg D. (1999)
An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae. (PubMed id 9405607)^{1, 3} Archambault J....Greenblatt J. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9150	HGNC: 2498	AceView: CTDP1	Ensembl:ENSG00000060069	euGenes: HUgn9150
ECgene: CTDP1	H-InvDB: CTDP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CTDP1	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CTDP1

Intellectual Property for CTDP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CTDP1 gene:
Search GeneIP for patents involving CTDP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CTDP1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTDP1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTDP1
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CTDP1		OriGene 3'-UTR Clone for CTDP1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTDP1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTDP1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CTDP1		OriGene Custom Protein Services for CTDP1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTDP1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTDP1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTDP1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTDP1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTDP1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTDP1

	GenScript Custom Purified and Recombinant Proteins Services for CTDP1		GenScript cDNA clones with any tag delivered in your preferred vector for CTDP1
	GenScript Custom Assay Services for CTDP1		GenScript Custom Superior Antibodies Services for CTDP1
	GenScript Custom overexpressing Cell Line Services for CTDP1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CTDP1 promoter
	Search Chromatin IP Primers for CTDP1
	RT² qPCR Primer Assay in human, mouse, rat CTDP1
	GNC Network for CTDP1
	SABiosciences Custom PCR Arrays for CTDP1

Search Tocris compounds for CTDP1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CTDP1 antibodies
	CTDP1 proteins

	Antibodies for CTDP1
	See all of Abcam's Antibodies, Kits and Proteins for CTDP1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CTDP1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CTDP1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDP1

	SwitchGear 3'UTR luciferase reporter plasmids for CTDP1
	SwitchGear Promoter luciferase reporter plasmids for CTDP1

ThermoFisher Antibodies for CTDP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDP1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CTDP1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CTDP1 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide...

Aliases
for CTDP1 gene

Summaries
for CTDP1 gene

Genomic Views
for CTDP1 gene

Proteins
for CTDP1 gene

Protein Domains /
Families
for CTDP1 gene

Function
for CTDP1 gene

Pathways & Interactions
for CTDP1 gene

Drugs & Compounds
for CTDP1 gene

Transcripts
for CTDP1 gene

Expression
for CTDP1 gene

Orthologs
for CTDP1 gene

Paralogs
for CTDP1 gene

Genomic Variants
for CTDP1 gene

Disorders / Diseases
for CTDP1 gene

Publications
for CTDP1 gene

External Searches for CTDP1 gene

Genome Databases showing CTDP1 gene

Other Databases showing CTDP1 gene

Specialized Databases showing CTDP1 gene

Intellectual Property
for CTDP1 gene

Products
for CTDP1 gene

View Random Gene

Advanced Search

Export list of displayed genes

CTDP1 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide...

Aliasesfor CTDP1 gene

Summariesfor CTDP1 gene

Genomic Viewsfor CTDP1 gene

Proteinsfor CTDP1 gene

Protein Domains /Familiesfor CTDP1 gene

Functionfor CTDP1 gene

Pathways & Interactionsfor CTDP1 gene

Drugs & Compoundsfor CTDP1 gene

Transcriptsfor CTDP1 gene

Expression for CTDP1 gene

Orthologsfor CTDP1 gene

Paralogsfor CTDP1 gene

Genomic Variantsfor CTDP1 gene

Disorders / Diseasesfor CTDP1 gene

Publicationsfor CTDP1 gene

External Searches for CTDP1 gene

Genome Databases showing CTDP1 gene

Other Databases showing CTDP1 gene

Specialized Databases showing CTDP1 gene

Intellectual Propertyfor CTDP1 gene

Productsfor CTDP1 gene

View Random Gene

Aliases
for CTDP1 gene

Summaries
for CTDP1 gene

Genomic Views
for CTDP1 gene

Proteins
for CTDP1 gene

Protein Domains /
Families
for CTDP1 gene

Function
for CTDP1 gene

Pathways & Interactions
for CTDP1 gene

Drugs & Compounds
for CTDP1 gene

Transcripts
for CTDP1 gene

Expression
for CTDP1 gene

Orthologs
for CTDP1 gene

Paralogs
for CTDP1 gene

Genomic Variants
for CTDP1 gene

Disorders / Diseases
for CTDP1 gene

Publications
for CTDP1 gene

Intellectual Property
for CTDP1 gene

Products
for CTDP1 gene