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Aliases for CTDNEP1 Gene

Aliases for CTDNEP1 Gene

  • CTD Nuclear Envelope Phosphatase 1 2 3
  • DULLARD 3 4 6
  • C-Terminal Domain Nuclear Envelope Phosphatase 1 2 3
  • Serine/Threonine-Protein Phosphatase Dullard 3 4
  • Dullard Homolog (Xenopus Laevis) 2
  • Dullard Homolog 3
  • EC 3.1.3.16 4
  • HSA011916 3
  • NET56 3

External Ids for CTDNEP1 Gene

Previous Symbols for CTDNEP1 Gene

  • DULLARD

Summaries for CTDNEP1 Gene

GeneCards Summary for CTDNEP1 Gene

CTDNEP1 (CTD Nuclear Envelope Phosphatase 1) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity.

UniProtKB/Swiss-Prot for CTDNEP1 Gene

  • Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTDNEP1 Gene

Genomics for CTDNEP1 Gene

Genomic Location for CTDNEP1 Gene

Start:
7,243,587 bp from pter
End:
7,252,491 bp from pter
Size:
8,905 bases
Orientation:
Minus strand

Genomic View for CTDNEP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTDNEP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTDNEP1 Gene

No data available for Regulatory Elements for CTDNEP1 Gene

Proteins for CTDNEP1 Gene

  • Protein details for CTDNEP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95476-CNEP1_HUMAN
    Recommended name:
    CTD nuclear envelope phosphatase 1
    Protein Accession:
    O95476
    Secondary Accessions:
    • D3DTN7
    • Q96GQ9

    Protein attributes for CTDNEP1 Gene

    Size:
    244 amino acids
    Molecular mass:
    28377 Da
    Quaternary structure:
    • Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2.

neXtProt entry for CTDNEP1 Gene

Proteomics data for CTDNEP1 Gene at MOPED

Post-translational modifications for CTDNEP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CTDNEP1 Gene

Domains for CTDNEP1 Gene

Gene Families for CTDNEP1 Gene

HGNC:
  • CTD :Serine/threonine phosphatases / CTD aspartate-based phosphatases

Protein Domains for CTDNEP1 Gene

UniProtKB/Swiss-Prot:

CNEP1_HUMAN
Domain:
  • Contains 1 FCP1 homology domain.:
    • O95476
Family:
  • Belongs to the dullard family.:
    • O95476
genes like me logo Genes that share domains with CTDNEP1: view

Function for CTDNEP1 Gene

Molecular function for CTDNEP1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=18 mM for p-nitrophenylphosphate {ECO:0000269 PubMed:17420445}; pH dependence: Optimum pH is 5.5. {ECO:0000269 PubMed:17420445};
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling.

Enzyme Numbers (IUBMB) for CTDNEP1 Gene

Gene Ontology (GO) - Molecular Function for CTDNEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity TAS --
GO:0005515 protein binding IPI 22134922
GO:0016791 phosphatase activity --
genes like me logo Genes that share ontologies with CTDNEP1: view
genes like me logo Genes that share phenotypes with CTDNEP1: view

Animal Models for CTDNEP1 Gene

MGI Knock Outs for CTDNEP1:

miRNA for CTDNEP1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for CTDNEP1 Gene

Localization for CTDNEP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTDNEP1 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for CTDNEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope TAS --
GO:0005737 cytoplasm IDA 22134922
GO:0005789 endoplasmic reticulum membrane IDA 17420445
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CTDNEP1: view

Pathways for CTDNEP1 Gene

SuperPathways for CTDNEP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTDNEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006470 protein dephosphorylation IDA 17420445
GO:0006998 nuclear envelope organization IDA 17420445
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0007276 gamete generation IEA --
genes like me logo Genes that share ontologies with CTDNEP1: view

No data available for Pathways by source for CTDNEP1 Gene

Transcripts for CTDNEP1 Gene

Unigene Clusters for CTDNEP1 Gene

CTD nuclear envelope phosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTDNEP1 Gene

No ASD Table

Relevant External Links for CTDNEP1 Gene

GeneLoc Exon Structure for
CTDNEP1
ECgene alternative splicing isoforms for
CTDNEP1

Expression for CTDNEP1 Gene

mRNA expression in normal human tissues for CTDNEP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTDNEP1 Gene

SOURCE GeneReport for Unigene cluster for CTDNEP1 Gene Hs.513913

mRNA Expression by UniProt/SwissProt for CTDNEP1 Gene

O95476-CNEP1_HUMAN
Tissue specificity: Muscle specific with lower expression in other metabolic tissues.
genes like me logo Genes that share expressions with CTDNEP1: view

Orthologs for CTDNEP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CTDNEP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTDNEP1 36
  • 99.86 (n)
  • 100 (a)
CTDNEP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CTDNEP1 36
  • 96.17 (n)
  • 99.59 (a)
CTDNEP1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTDNEP1 36
  • 95.22 (n)
  • 99.59 (a)
CTDNEP1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ctdnep1 36
  • 93.44 (n)
  • 99.59 (a)
Ctdnep1 16
Ctdnep1 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTDNEP1 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ctdnep1 36
  • 94.26 (n)
  • 99.59 (a)
lizard
(Anolis carolinensis)
Reptilia CTDNEP1 37
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ctdnep1 36
  • 76.91 (n)
  • 93.03 (a)
zebrafish
(Danio rerio)
Actinopterygii ctdnep1a 36
  • 77.87 (n)
  • 90.57 (a)
ctdnep1a 37
  • 90 (a)
OneToMany
ctdnep1b 37
  • 89 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006231 36
  • 64.98 (n)
  • 70.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dd 36
  • 65.54 (n)
  • 70.89 (a)
Dd 37
  • 69 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cnep-1 37
  • 59 (a)
OneToOne
scpl-2 36
  • 59.38 (n)
  • 67.65 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NEM1 37
  • 21 (a)
OneToOne
NEM1 39
bread mold
(Neurospora crassa)
Ascomycetes NCU08948 36
  • 54.1 (n)
  • 50.86 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9125 37
  • 56 (a)
OneToOne
Species with no ortholog for CTDNEP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTDNEP1 Gene

ENSEMBL:
Gene Tree for CTDNEP1 (if available)
TreeFam:
Gene Tree for CTDNEP1 (if available)

Paralogs for CTDNEP1 Gene

Selected SIMAP similar genes for CTDNEP1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for CTDNEP1 Gene

genes like me logo Genes that share paralogs with CTDNEP1: view

No data available for Paralogs for CTDNEP1 Gene

Variants for CTDNEP1 Gene

Sequence variations from dbSNP and Humsavar for CTDNEP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2074217 -- 7,247,233(+) GAGCT(A/G)GCCCC intron-variant
rs2521987 -- 7,248,603(+) CCACC(C/T)GCCTC intron-variant
rs2654186 -- 7,247,792(+) caacc(A/C)taata intron-variant
rs9899339 -- 7,248,028(+) gaggc(A/C)aaggc intron-variant
rs9899344 -- 7,248,037(+) gcagg(A/C)ggatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTDNEP1 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
esv2665200 CNV Deletion 23128226
dgv3053n71 CNV Loss 21882294
nsv907637 CNV Loss 21882294
nsv907640 CNV Loss 21882294
nsv1963 CNV Loss 18451855

Relevant External Links for CTDNEP1 Gene

HapMap Linkage Disequilibrium report
CTDNEP1

Disorders for CTDNEP1 Gene

No disorders were found for CTDNEP1 Gene.

No data available for UniProtKB/Swiss-Prot for CTDNEP1 Gene

Publications for CTDNEP1 Gene

  1. Molecular cloning and characterization of dullard: a novel gene required for neural development. (PMID: 12083771) Satow R. … Asashima M. (Biochem. Biophys. Res. Commun. 2002) 2 3 4
  2. Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction. (PMID: 17141153) Satow R. … Asashima M. (Dev. Cell 2006) 2 3
  3. Nuclear envelope phosphatase-regulatory subunit 1 (formerly TMEM188) is the metazoan SPO7 ortholog and functions in the lipin activation pathway. (PMID: 22134922) Han S. … Goodman J.M. (J. Biol. Chem. 2012) 3 4
  4. A conserved phosphatase cascade that regulates nuclear membrane biogenesis. (PMID: 17420445) Kim Y. … Dixon J.E. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for CTDNEP1 Gene

Sources for CTDNEP1 Gene

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