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CTDNEP1 Gene

protein-coding   GIFtS: 48
GCID: GC17M007147

CTD Nuclear Envelope Phosphatase 1

(Previous name: dullard homolog (Xenopus laevis))
(Previous symbol: DULLARD)
  Search for CTDNEP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CTD Nuclear Envelope Phosphatase 11 2     HSA0119162
DULLARD1 2 3 5     NET562
C-Terminal Domain Nuclear Envelope Phosphatase 11 2     Dullard Homolog2
Serine/Threonine-Protein Phosphatase Dullard2 3     EC 3.1.3.163
Dullard Homolog (Xenopus Laevis)1     

External Ids:    HGNC: 190851   Entrez Gene: 233992   Ensembl: ENSG000001758267   OMIM: 6106845   UniProtKB: O954763   

Export aliases for CTDNEP1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CTDNEP1 Gene:
CTDNEP1 (CTD nuclear envelope phosphatase 1) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine phosphatase activity.

UniProtKB/Swiss-Prot: CNEP1_HUMAN, O95476
Function: Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that
dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze
the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents
levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be
required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of
lipid droplets and triacylglycerol. May antagonize BMP signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CTDNEP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCTDNEP1 promoter sequence
   Search Chromatin IP Primers for CTDNEP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTDNEP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13

CTDNEP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTDNEP1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007147:  view genomic region     (about GC identifiers)

Start:
7,146,906 bp from pter      End:
7,155,810 bp from pter
Size:
8,905 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CNEP1_HUMAN, O95476 (See protein sequence)
Recommended Name: CTD nuclear envelope phosphatase 1  
Size: 244 amino acids; 28377 Da
Subunit: Interacts with CNEP1R1; the complex dephosphorylates LPIN1 and LPIN2
Secondary accessions: D3DTN7 Q96GQ9

Explore the universe of human proteins at neXtProt for CTDNEP1: NX_O95476

Explore proteomics data for CTDNEP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CTDNEP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137247.1  NP_056158.2  

    ENSEMBL proteins: 
     ENSP00000460527   ENSP00000460683   ENSP00000461749   ENSP00000458758   ENSP00000321732  
     ENSP00000459866   ENSP00000458763   ENSP00000461122   ENSP00000461567   ENSP00000458408  
    Reactome Protein details: O95476

    CTDNEP1 Human Recombinant Protein Products:

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    Novus Biologicals CTDNEP1 Protein
    Novus Biologicals CTDNEP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    CTDNEP1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for CTDNEP1

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    Search eBioscience for ELISAs for CTDNEP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CTD: Serine/threonine phosphatases / CTD aspartate-based phosphatases

    3 InterPro protein domains:
     IPR023214 HAD-like_dom
     IPR011948 Dullard_phosphatase
     IPR004274 NIF

    Graphical View of Domain Structure for InterPro Entry O95476

    ProtoNet protein and cluster: O95476

    1 Blocks protein domain: IPB004274 NLI interacting factor

    UniProtKB/Swiss-Prot: CNEP1_HUMAN, O95476
    Similarity: Belongs to the dullard family
    Similarity: Contains 1 FCP1 homology domain


    Find genes that share domains with CTDNEP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CNEP1_HUMAN, O95476
    Function: Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that
    dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze
    the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents
    levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be
    required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of
    lipid droplets and triacylglycerol. May antagonize BMP signaling
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
    Biophysicochemical properties: Kinetic parameters: KM=18 mM for p-nitrophenylphosphate; pH dependence: Optimum pH
    is 5.5;

         Enzyme Number (IUBMB): EC 3.1.3.161

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004722protein serine/threonine phosphatase activity IMP17420445
    GO:0005515protein binding IPI--
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with CTDNEP1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CTDNEP1:
     Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ctdnep1):
     cellular  embryogenesis  mortality/aging  renal/urinary system  reproductive system 

    Find genes that share phenotypes with CTDNEP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ctdnep1tm1Ryn for CTDNEP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTDNEP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTDNEP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTDNEP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTDNEP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CTDNEP1:
    hsa-mir-1229-3p (MIRT036334), hsa-mir-26b-5p (MIRT029871), hsa-mir-1226-3p (MIRT036478), hsa-mir-1 (MIRT023923)

    Block miRNA regulation of human, mouse, rat CTDNEP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTDNEP1 (see all 12):
    hsa-miR-485-5p hsa-miR-4328 hsa-miR-122 hsa-miR-622 hsa-miR-605 hsa-miR-3065-5p hsa-miR-551b* hsa-miR-4316
    SwitchGear 3'UTR luciferase reporter plasmidCTDNEP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CTDNEP1
    Predesigned siRNA for gene silencing in human, mouse, rat CTDNEP1

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CTDNEP1 (NM_001143775)
    Sino Biological Human cDNA Clone for CTDNEP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTDNEP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDNEP1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CTDNEP1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDNEP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CNEP1_HUMAN, O95476: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass
    membrane protein

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IDA17420445
    GO:0005737cytoplasm IDA--
    GO:0005789endoplasmic reticulum membrane IDA17420445
    GO:0016021integral component of membrane IEA--
    GO:0031965nuclear membrane IDA--

    Find genes that share ontologies with CTDNEP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Find genes that share SuperPaths with CTDNEP1           About GenesLikeMe

    Pathways by sourceSee SuperPaths
    Show all pathways



    1 Reactome Pathway for CTDNEP1
        Depolymerisation of the Nuclear Lamina


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTDNEP1
    Interactions:

        Search GeneGlobe Interaction Network for CTDNEP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CTDNEP1 (O954761, 3 ENSP000003217324) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNEP1R1Q8N9A81, ENSP000004056354EBI-5323433,EBI-5323455 STRING: ENSP00000405635
    NANPQ8TBE93I2D: score=4 
    CYCSENSP000003077864STRING: ENSP00000307786
    PPP1CAENSP000003260314STRING: ENSP00000326031
    PPP1R12AENSP000002612074STRING: ENSP00000261207
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IDA17420445
    GO:0006998nuclear envelope organization IDA17420445
    GO:0010867positive regulation of triglyceride biosynthetic process IGI--
    GO:0034504protein localization to nucleus IDA--

    Find genes that share ontologies with CTDNEP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTDNEP1 (CNEP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTDNEP1 gene (2 alternative transcripts): 
    NM_001143775.1  NM_015343.4  

    Unigene Cluster for CTDNEP1:

    CTD nuclear envelope phosphatase 1
    Hs.513913  [show with all ESTs]
    Unigene Representative Sequence: NM_015343
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570828 ENST00000574322(uc002gfd.2 uc002gfe.2) ENST00000573600
    ENST00000574205 ENST00000318988 ENST00000572043 ENST00000570484 ENST00000576613
    ENST00000575783 ENST00000570385 ENST00000570380 ENST00000571409
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CTDNEP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTDNEP1 (see all 12):
    hsa-miR-485-5p hsa-miR-4328 hsa-miR-122 hsa-miR-622 hsa-miR-605 hsa-miR-3065-5p hsa-miR-551b* hsa-miR-4316
    SwitchGear 3'UTR luciferase reporter plasmidCTDNEP1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CTDNEP1 (NM_001143775)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTDNEP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTDNEP1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CTDNEP1
      QuantiTect SYBR Green Assays in human, mouse, rat CTDNEP1
      QuantiFast Probe-based Assays in human, mouse, rat CTDNEP1

    Additional mRNA sequence: 

    AJ011916.1 AY364239.1 BC009295.2 

    Selected DOTS entries (see all 25):

    DT.99937435  DT.95163850  DT.99957873  DT.450749  DT.120968467  DT.97815358  DT.100822729  DT.100808943 
    DT.120968797  DT.120968540  DT.99968689  DT.100808957  DT.120968539  DT.97860299  DT.120968636  DT.100734388 
    DT.100808950  DT.100808954  DT.87079522  DT.91959307  DT.95370686  DT.100796871  DT.120862573  DT.120968557 

    Selected AceView cDNA sequences (see all 672):

    BQ437256 CR625645 AI587171 CF130158 CA442960 CD675069 AI024256 AW571512 
    BE855808 BG746404 AW511436 BM450012 AI364059 AA678902 BU179461 BM818900 
    AA774393 BM309960 AA477128 BX384546 BM999373 BM764363 CR606307 BG912922 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTDNEP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTATAACT
    CTDNEP1 Expression
    About this image

    CTDNEP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTDNEP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513913

    UniProtKB/Swiss-Prot: CNEP1_HUMAN, O95476
    Tissue specificity: Muscle specific with lower expression in other metabolic tissues

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    QuantiTect SYBR Green Assays in human, mouse, rat CTDNEP1
    QuantiFast Probe-based Assays in human, mouse, rat CTDNEP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTDNEP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CTDNEP1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctdnep11 , 5 CTD nuclear envelope phosphatase 11, 5 93.44(n)1
    99.59(a)1
      11 (42.95 cM)5
    671811  NM_026017.21  NP_080293.11 
     699811565 
    lizard
    (Anolis carolinensis)
    Reptilia CTDNEP16
    CTD nuclear envelope phosphatase 1
    88(a)
    1 ↔ 1
    GL344421.1(21-16420)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ctdnep11 CTD nuclear envelope phosphatase 1 76.91(n)
    93.03(a)
      549931  NM_001017177.2  NP_001017177.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ctdnep1a1 CTD nuclear envelope phosphatase 1a 77.87(n)
    90.57(a)
      492343  NM_001007309.1  NP_001007310.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dd1 Dullard 65.54(n)
    70.89(a)
      33107  NM_134605.2  NP_608449.1 
    worm
    (Caenorhabditis elegans)
    Secernentea scpl-21 scpl-2 59.38(n)
    67.65(a)
      185802  NM_001267194.1  NP_001254123.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NEM1(YHR004C)4 Probable catalytic subunit of Nem1p-Spo7p phosphatase more   --   8(113094-111754) 856393  NP_011867.1 


    ENSEMBL Gene Tree for CTDNEP1 (if available)
    TreeFam Gene Tree for CTDNEP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTDNEP1 gene
    3 SIMAP similar genes for CTDNEP1 using alignment to 7 protein entries:     CNEP1_HUMAN (see all proteins):
    CTDSPL    CTDSP2    CTDSP1

    Find genes that share paralogs with CTDNEP1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CTDNEP1
    PGOHUM00000238135 PGOHUM00000235650


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTDNEP1 (see all 99)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1133026101,2
    C--7147873(+) ACCTGA/GGGGCA 4 P L mis10--------
    rs1859387001,2
    --7148297(+) CATAAC/TGAGAT 2 -- int10--------
    rs1407306561,2
    --7148387(+) CGGACA/GAATCA 2 -- int10--------
    rs1908429381,2
    --7148559(+) TAAGCC/TGAGAT 2 -- int10--------
    rs1808670251,2
    --7148567(+) GATCAC/TGCCAC 2 -- int10--------
    rs1861132641,2
    --7148608(+) TCTGTC/GTCAAA 2 -- int10--------
    rs1909659381,2
    --7148680(+) TGAGAA/GGCTGA 2 -- int10--------
    rs1125404021,2
    C,F--7149208(+) AATAAG/CTTGCA 2 -- int11Minor allele frequency- C:0.50NA 2
    rs782383141,2
    --7149213(+) CTTGCA/GTTTCG 2 -- int10--------
    rs1995463601,2
    C--7149320(+) TCCTGC/TCAGAC 2 -- int10--------

    HapMap Linkage Disequilibrium report for CTDNEP1 (7146906 - 7155810 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CTDNEP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665200CNV Deletion23128226
    esv2422288CNV Deletion17116639
    nsv907637CNV Loss21882294
    dgv3053n71CNV Loss21882294
    nsv907640CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv1963CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610684    OMIM disorders: --


    Find genes that share disorders with CTDNEP1           About GenesLikeMe


    Export disorders for CTDNEP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTDNEP1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with CTDNEP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of dullard: a novel gene required for neural development. (PubMed id 12083771)1, 2, 3 Satow R.... Asashima M. (Biochem. Biophys. Res. Commun. 2002)
    2. Nuclear envelope phosphatase-regulatory subunit 1 (formerly TMEM188) is the metazoan SPO7 ortholog and functions in the lipin activation pathway. (PubMed id 22134922)1, 2 Han S.... Goodman J.M. (J. Biol. Chem. 2012)
    3. A conserved phosphatase cascade that regulates nuclear membrane biogenesis. (PubMed id 17420445)1, 2 Kim Y....Dixon J.E. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    4. Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction. (PubMed id 17141153)1, 3 Satow R....Asashima M. (Dev. Cell 2006)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Homo sapiens dullard protein phosphatase shows a preference for the insulin-dependent phosphorylation site of lipin1. (PubMed id 21413788)1 Wu R....Allen K.N. (Biochemistry 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. NovelFam3000 -- uncharacterized human protein domains conserved across model organisms. (PubMed id 16533400)2 Kemmer D.... Wasserman W.W. (BMC Genomics 2006)
    10. Determinants for dephosphorylation of the RNA polymerase II C- terminal domain by Scp1. (PubMed id 17157258)1 Zhang Y.... Noel J.P. (Mol. Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23399 HGNC: 19085 AceView: CLDN7andGABARAPandDULLARD Ensembl:ENSG00000175826 euGenes: HUgn23399
    ECgene: CTDNEP1 H-InvDB: CTDNEP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CTDNEP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTDNEP1 gene:
    Search GeneIP for patents involving CTDNEP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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