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CTCFL Gene

protein-coding   GIFtS: 54
GCID: GC20M056064

CCCTC-Binding Factor (Zinc Finger Protein)-Like

  Search for CTCFL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CCCTC-Binding Factor (Zinc Finger Protein)-Like1 2     HMG-1L12
Cancer/Testis Antigen 271 2 3     HMGB1L12
BORIS2 3 5     BORIS-Like Protein2
Brother Of The Regulator Of Imprinted Sites2 3     dJ579F20.22
Zinc Finger Protein CTCF-T2 3     Putative High Mobility Group Protein 1-Like 12
CT272 3     Putative High Mobility Group Protein B1-Like 12
CTCF Paralog2 3     Transcriptional Repressor CTCFL2
CTCF-Like Protein2 3     CCCTC-Binding Factor3
CTCF-T2     

External Ids:    HGNC: 162341   Entrez Gene: 1406902   Ensembl: ENSG000001240927   OMIM: 6070225   UniProtKB: Q8NI513   

Export aliases for CTCFL gene to outside databases

Previous GC identifers: GC20M055800 GC20M056710 GC20M056757 GC20M055505 GC20M052853


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CTCFL Gene:
CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers
to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome
inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of
spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein
encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of
methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jun 2012)

GeneCards Summary for CTCFL Gene:
CTCFL (CCCTC-binding factor (zinc finger protein)-like) is a protein-coding gene. GO annotations related to this gene include histone binding and sequence-specific DNA binding. An important paralog of this gene is CTCF.

UniProtKB/Swiss-Prot: CTCFL_HUMAN, Q8NI51
Function: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and
transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in
gene imprinting in male germline, by participating in the establishment of differential methylation at the
IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7
methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de
novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with
DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for
dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters

Gene Wiki entry for CTCFL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the CTCFL gene promoter:
         NF-1   Sp1   Brachyury   CUTL1   PPAR-gamma1   USF-1   Chx10   SEF-1 (1)   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CTCFL promoter sequence
   Search Chromatin IP Primers for CTCFL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CTCFL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.31   Ensembl cytogenetic band:  20q13.31   HGNC cytogenetic band: 20q13.31

CTCFL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTCFL gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M056064:  view genomic region     (about GC identifiers)

Start:
56,071,035 bp from pter      End:
56,100,708 bp from pter
Size:
29,674 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CTCFL_HUMAN, Q8NI51 (See protein sequence)
Recommended Name: Transcriptional repressor CTCFL  
Size: 663 amino acids; 75747 Da
Subunit: Interacts with histones, PRMT7 and SETD1A. Interacts (via N-terminus) with BAG6/BAT3
Developmental stage: Is up-regulated in primary spermatocytes (expression overlapping with the genome-wide erasure
of methylation) to become silenced on activation of CTCF in post-meiotic germline cells (expression corresponding
to DNA remethylation)
Secondary accessions: A0S6W1 A1L4C6 A6XGL8 A6XGM2 A6XGM3 A6XGM8 A6XGN0 A6XGN1 A6XGN3 E7EQ27
E7EUE3 E9PBA9 Q5JUG4 Q9BZ30 Q9NQJ3
Alternative splicing: 9 isoforms:  Q8NI51-1   Q8NI51-2   Q8NI51-3   Q8NI51-4   Q8NI51-5   Q8NI51-6   Q8NI51-7   Q8NI51-8   
Q8NI51-9   

Explore the universe of human proteins at neXtProt for CTCFL: NX_Q8NI51

Explore proteomics data for CTCFL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CTCFL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (16 alternative transcripts): 
    NP_001255969.1  NP_001255970.1  NP_001255971.1  NP_001255972.1  NP_001255973.1  NP_001255974.1  NP_001255975.1  NP_001255976.1  
    NP_001255977.1  NP_001255978.1  NP_001255979.1  NP_001255980.1  NP_001255981.1  NP_001255983.1  NP_001255984.1  NP_542185.2  

    ENSEMBL proteins: 
     ENSP00000415579   ENSP00000476783   ENSP00000476398   ENSP00000415329   ENSP00000243914  
     ENSP00000360239   ENSP00000477488   ENSP00000403369   ENSP00000413713   ENSP00000437999  
     ENSP00000392034   ENSP00000409344   ENSP00000439998   ENSP00000476718   ENSP00000399061  
     ENSP00000476458   ENSP00000477412   ENSP00000477165   ENSP00000476577  

    CTCFL Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CTCFL
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    Novus Biologicals CTCFL Protein
    Novus Biologicals CTCFL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CTCFL

     
    Search eBioscience for Proteins for CTCFL 

    CTCFL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CTCFL
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CTCFL  (BORIS)
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    OriGene Custom Antibody Services for CTCFL
    Novus Biologicals CTCFL Antibodies
    Abcam antibodies for CTCFL
    Cloud-Clone Corp. Antibodies for CTCFL
    Search ThermoFisher Antibodies for CTCFL
    LSBio Antibodies in human, mouse, rat for CTCFL

    CTCFL Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CTCFL
    Cloud-Clone Corp. CLIAs for CTCFL
    Search eBioscience for ELISAs for CTCFL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8NI51

    ProtoNet protein and cluster: Q8NI51

    UniProtKB/Swiss-Prot: CTCFL_HUMAN, Q8NI51
    Similarity: Belongs to the CTCF zinc-finger protein family
    Similarity: Contains 11 C2H2-type zinc fingers


    Find genes that share domains with CTCFL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CTCFL_HUMAN, Q8NI51
    Function: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and
    transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in
    gene imprinting in male germline, by participating in the establishment of differential methylation at the
    IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7
    methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de
    novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with
    DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for
    dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IDA18413740
    GO:0005515protein binding IPI18765639
    GO:0042393histone binding ISS--
    GO:0043565sequence-specific DNA binding ISS--
         
    Find genes that share ontologies with CTCFL           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ctcfl):
     cellular  endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with CTCFL           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CTCFL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CTCFL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CTCFL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CTCFL

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  CNNBRGCGCCCCCTGSTGGC 

    miRNA
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    Block miRNA regulation of human, mouse, rat CTCFL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CTCFL (see all 16):
    hsa-miR-548w hsa-miR-548j hsa-miR-579 hsa-miR-548p hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p
    SwitchGear 3'UTR luciferase reporter plasmidCTCFL 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CTCFL
    Predesigned siRNA for gene silencing in human, mouse, rat CTCFL

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CTCFL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CTCFL (NM_080618)
    Sino Biological Human cDNA Clone for CTCFL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTCFL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTCFL

    Cell Line
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12429) for CTCFL 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CTCFL_HUMAN, Q8NI51: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CTCFL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CTCFL About    
    See pathways by source

    SuperPathContained pathways About
    1Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with CTCFL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CTCFL
        Chromatin Regulation / Acetylation



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CTCFL
    Interactions:

        GeneGlobe Interaction Network for CTCFL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for CTCFL (Q8NI513 ENSP000002439144) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006349regulation of gene expression by genetic imprinting ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0007049cell cycle IEA--
    GO:0010628positive regulation of gene expression IDA18413740
    GO:0016571histone methylation ISS--

    Find genes that share ontologies with CTCFL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CTCFL

    1 Novoseek inferred chemical compound relationship for CTCFL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 77.9 18 16140943 (2), 18095639 (1), 17260018 (1), 20305816 (1) (see all 5)



    Find genes that share compounds with CTCFL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CTCFL gene (16 alternative transcripts): 
    NM_001269040.1  NM_001269041.1  NM_001269042.1  NM_001269043.1  NM_001269044.1  NM_001269045.1  NM_001269046.1  NM_001269047.1  
    NM_001269048.1  NM_001269049.1  NM_001269050.1  NM_001269051.1  NM_001269052.1  NM_001269054.1  NM_001269055.1  NM_080618.3  

    Unigene Cluster for CTCFL:

    CCCTC-binding factor (zinc finger protein)-like
    Hs.131543  [show with all ESTs]
    Unigene Representative Sequence: DQ778110
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000423479(uc010giu.3 uc010giw.1) ENST00000608263 ENST00000609232
    ENST00000429804(uc010gjb.1 uc010gja.1) ENST00000243914(uc002xym.2 uc021wff.1 uc021wfg.1)
    ENST00000371196(uc010gix.1 uc010gjc.1 uc010gjd.1) ENST00000608440
    ENST00000426658 ENST00000422109 ENST00000502686(uc010giv.3 uc010gjg.3)
    ENST00000433949(uc010gje.3 uc021wfe.1 uc010gjf.3) ENST00000432255(uc010gjh.2 uc010gjk.1)
    ENST00000539382(uc010gji.2) ENST00000608903 ENST00000422869(uc010gjj.2 uc010gjl.1)
    ENST00000608425 ENST00000608720 ENST00000607923
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CTCFL (see all 16):
    hsa-miR-548w hsa-miR-548j hsa-miR-579 hsa-miR-548p hsa-miR-559 hsa-miR-548h hsa-miR-548i hsa-miR-548c-5p
    SwitchGear 3'UTR luciferase reporter plasmidCTCFL 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CTCFL (NM_080618)
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat CTCFL
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12429) for CTCFL 

    Additional mRNA sequence: 

    AF336042.1 AK128070.1 AK313990.1 AY071919.1 BC060763.1 BC130486.1 BC137482.1 BC137483.1 
    DQ294738.1 DQ778108.1 DQ778109.1 DQ778110.1 DQ778111.1 DQ778112.1 DQ778113.1 DQ778114.1 
    DQ778115.2 DQ778116.2 DQ778117.2 DQ778118.2 DQ778119.2 DQ778120.2 DQ778121.3 DQ778122.2 
    DQ778123.2 DQ778124.2 DQ778125.2 DQ778126.2 DQ778127.2 DQ778128.2 DQ778129.2 DQ778130.1 
    DQ778131.1 NR_072975.1 

    6 DOTS entries:

    DT.101979256  DT.303300  DT.99957215  DT.100696089  DT.97768285  DT.100052897 

    Selected AceView cDNA sequences (see all 27):

    BX094837 AI024580 BX282332 AY071919 NM_080618 AI024578 AL844306 BG527694 
    BC060763 AL844477 BU629814 BG687495 BU170289 AK128070 AL732020 AF336042 
    AL844280 BG722482 AL844304 BQ429595 AL049118 BF209606 AL844410 AW243377 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CTCFL    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:                                                                                    
    SP2:        -                                                                           
    SP3:                                                                                    


    ECgene alternative splicing isoforms for CTCFL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CTCFL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCCCTGTG
    CTCFL Expression
    About this image


    CTCFL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Testis (Reproductive System)
    CTCFL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CTCFL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131543

    UniProtKB/Swiss-Prot: CTCFL_HUMAN, Q8NI51
    Tissue specificity: Testis specific. Specifically expressed in primary spermatocytes

        Custom PCR Arrays for CTCFL
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    QuantiFast Probe-based Assays in human, mouse, rat CTCFL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTCFL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CTCFL gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ctcfl1 , 5 CCCTC-binding factor (zinc finger protein)-like1, 5 68.75(n)1
    60.83(a)1
      2 (95.74 cM)5
    6647991  NM_001081387.21  NP_001074856.11 
     1730936095 
    lizard
    (Anolis carolinensis)
    Reptilia CTCFL6
    CCCTC-binding factor (zinc finger protein)-like
    53(a)
    1 ↔ 1
    GL343217.1(1033070-1048475)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1120836
    zgc:112083
    18(a)
    many ↔ many
    15(18951710-18965512) ENSDARG00000037405
    fruit fly
    (Drosophila melanogaster)
    Insecta CTCF6
    CTCF
    24(a)
    1 → many
    3L(7346678-7349813)


    ENSEMBL Gene Tree for CTCFL (if available)
    TreeFam Gene Tree for CTCFL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CTCFL gene
    CTCF2  HINFP2  ZFP642  
    Selected SIMAP similar genes for CTCFL using alignment to 6 protein entries:     CTCFL_HUMAN (see all proteins) (see all similar genes):
    CTCF    ZNF55    ZNF78L1    ZFAT    ZNF    DKFZp686C13142
    ZNF333    ZNF705A    ZFP41    ZNF135    ZNF266    ZNF552
    ZNF567    ZNF624    ZNF699    ZNF778    ZNF782    KLF13

    Find genes that share paralogs with CTCFL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CTCFL (see all 819)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1913516591,2
    --56070566(+) AGTCAA/CGCACG 1 -- ds50010--------
    rs1843417711,2
    --56070567(+) GTCACA/GCACGT 1 -- ds50010--------
    rs1886486771,2
    --56070650(+) TGCAAA/CTATTT 1 -- ds50010--------
    rs1811314951,2
    C--56070698(+) GAGTCA/CCACTC 1 -- ds50010--------
    rs116998781,2
    H--56070713(+) gcccaA/Ggctgg 1 -- ds50010--------
    rs1853019821,2
    --56070751(+) GCAACC/TTCCGC 1 -- ds50010--------
    rs1460800341,2
    --56070762(+) CTCCCA/GGGTTC 1 -- ds50010--------
    rs1898776011,2
    --56070783(+) CCTGCC/TTCCGC 1 -- ds50010--------
    rs1824500901,2
    --56070787(+) CCTCCC/GCCCCC 1 -- ds50010--------
    rs1861966561,2
    --56070920(+) TGCCTC/TGGCCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CTCFL (56071035 - 56100708 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CTCFL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666374CNV Deletion23128226
    nsv3425CNV Insertion18451855
    nsv828758CNV Gain20364138
    esv25156CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CTCFL
    DNA2.0 Custom Variant and Variant Library Synthesis for CTCFL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607022    OMIM disorders: --


    Find genes that share disorders with CTCFL           About GenesLikeMe

    4 Novoseek inferred disease relationships for CTCFL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testicular cancer 48.6 1 17363524 (1)
    cancer 17.8 17 12191639 (3), 18095639 (2), 17363524 (2), 17962299 (2) (see all 6)
    cancer lung 11.7 9 16140944 (5), 17260018 (3)
    tumors 5.38 12 17062669 (2), 18095639 (1), 20305816 (1)

    Genetic Association Database (GAD): CTCFL
    Human Genome Epidemiology (HuGE) Navigator: CTCFL (2 documents)

    Export disorders for CTCFL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CTCFL gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with CTCFL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of the CTCF-paralogous cancer-testis gene, brother of the regulator of imprinted sites (BORIS), is regulated by three alternative promoters modulated by CpG methylation and by CTCF and p53 transcription factors. (PubMed id 17962299)1, 2, 9 Renaud S.... Lobanenkov V. (Nucleic Acids Res. 2007)
    2. The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. (PubMed id 12191639)1, 2, 9 Klenova E.M.... Lobanenkov V.V. (Semin. Cancer Biol. 2002)
    3. BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. (PubMed id 12011441)1, 2, 9 Loukinov D.I.... Lobanenkov V.V. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. The testis-specific factor CTCFL cooperates with the protein methyltransferase PRMT7 in H19 imprinting control region methylation. (PubMed id 17048991)1, 2, 9 Jelinic P.... Shaw P. (PLoS Biol. 2006)
    5. Susceptibility for breast cancer in young patients with short rare minisatellite alleles of BORIS. (PubMed id 21034534)1, 4 Yoon S.L....Leem S.H. (BMB Rep 2010)
    6. No evidence for mutations of CTCFL/BORIS in Silver-Russell syndrome patients with IGF2/H19 imprinting control region 1 hypomethylation. (PubMed id 19675668)1, 4 Bernier-Latmani J....Shaw P. (PLoS ONE 2009)
    7. DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. (PubMed id 18413740)1, 2 Sun L....Gius D. (Cancer Res. 2008)
    8. BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression. (PubMed id 18765639)1, 2 Nguyen P.... Gius D. (Mol. Cell. Biol. 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140690 HGNC: 16234 AceView: CTCFL Ensembl:ENSG00000124092 euGenes: HUgn140690
    ECgene: CTCFL H-InvDB: CTCFL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CTCFL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CTCFL gene:
    Search GeneIP for patents involving CTCFL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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