CTCF Gene
protein-coding GIFtS: 64
GCID: GC16P067596
|
|
CCCTC-binding factor (zinc finger protein)
| |
Aliases
for CTCF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CCCTC-Binding Factor (Zinc Finger Protein)1 2 | | 11-Zinc Finger Protein2 3 | | CTCFL Paralog2 3 | | 11 Zinc Finger Transcriptional Repressor2 | | Transcriptional Repressor CTCF2 | | CCCTC-Binding Factor3 |
Export aliases for CTCF gene to outside databasesPrevious GC identifers: GC16P058290 GC16P067974 GC16P067331 GC16P067373 GC16P067374 GC16P066153 GC16P053469 |
Summaries
for CTCF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CTCF:
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highlyconserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains tobind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind ahistone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histonedeacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to atranscriptional insulator element, it can block communication between enhancers and upstream promoters, therebyregulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostatecancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found forthis gene. (provided by RefSeq, Jul 2010)
UniProtKB/Swiss-Prot: CTCF_HUMAN, P49711Function: Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation bybinding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Actsas transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class IIgene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressingtranscription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates inthe allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within theH19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrictenhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome.Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintainingmethylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays a important role inchromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatinlooping. Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to acommon transcription factory. Causes local loss of histone acetylation and gain of histone methylation in thebeta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point fornucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix inestablishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing thepropagation of stable methylation at the escape genes from X- inactivation. Involved in sister chromatid cohesion.Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCFsites. Regulates asynchronous replication of IGF2/H19
Gene Wiki entry for CTCF
|
Genomic Views
for CTCF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CTCF gene promoter:
Egr-2 MEF-2A NF-1 NF-1/L p53 Nkx2-5 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CTCF
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTCF |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q21-q22.3 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q21-q22.3CTCF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P067596: view genomic region
(about GC identifiers)
Start:
|
67,596,310 bp from pter |
End:
|
67,673,088 bp from pter |
Size:
|
76,779 bases |
Orientation:
|
plus strand |
|
Proteins
for CTCF gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CTCF_HUMAN, P49711 (See
protein sequence)Recommended Name: Transcriptional repressor CTCF Size: 727 amino acids; 82785 Da
Subunit: Interacts with CHD8
Subcellular location: Nucleus, nucleoplasm. Chromosome. Chromosome, centromere. Note=May translocate to the nucleolusupon cell differentiation. Associates with both centromeres and chromosomal arms during metaphase. Associates with theH19 ICR in mitotic chromosomes. May be preferentially excluded from heterochromatin during interphase
Miscellaneous: More than 13'00 CTCF-binding sites in potential insulators were identified in the human genome
Sequence caution: Sequence=BAD93030.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from  and Proteopedia  for CTCF:1X6H (3D)
2CT1 (3D)
Secondary accessions: B5MC38 Q53XI7 Q59EL8Alternative splicing: 2 isoforms: P49711-1 P49711-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CTCF: NX_P49711
Post-translational modifications:
Sumoylated on Lys-74 and Lys-689; sumoylation of CTCF contributes to the repressive function of CTCF on the MYC P2promoter (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P49711
CTCF Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001177951.1 NP_006556.1
ENSEMBL proteins: ENSP00000264010 ENSP00000384707
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CTCF for ontologies About GeneDecksing
CTCF Antibody Products:
Assay Products for CTCF: |
Protein
Domains /
Families
for CTCF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CTCF for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P49711ProtoNet protein and cluster: P49711 1 Blocks protein family: IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: CTCF_HUMAN, P49711Domain: The 11 zinc fingers are highly conserved among vertebrates, exhibiting almost identical amino acid sequences.Different subsets or combination of individual zinc fingers gives the ability to CTCF to recognize multiple DNA targetsitesSimilarity: Belongs to the CTCF zinc-finger protein familySimilarity: Contains 11 C2H2-type zinc fingers |
Function
for CTCF gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CTCF_HUMAN, P49711Function: Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation bybinding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Actsas transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class IIgene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressingtranscription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates inthe allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within theH19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrictenhancer access to IGF2. Plays a critical role in gene silencing over considerable distances in the genome.Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintainingmethylation-free zones. Inversely, binding to target sites is prevented by CpG methylation. Plays a important role inchromatin remodeling. Can dimerize when it is bound to different DNA sequences, mediating long-range chromatinlooping. Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to acommon transcription factory. Causes local loss of histone acetylation and gain of histone methylation in thebeta-globin locus, without affecting transcription. When bound to chromatin, it provides an anchor point fornucleosomes positioning. Seems to be essential for homologous X-chromosome pairing. May participate with Tsix inestablishing a regulatable epigenetic switch for X chromosome inactivation. May play a role in preventing thepropagation of stable methylation at the escape genes from X- inactivation. Involved in sister chromatid cohesion.Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCFsites. Regulates asynchronous replication of IGF2/H19 Genatlas biochemistry entry for CTCF:Myc regulatory factor,expressed in cells of multiple lineages,in the chromosomal region deleted in sporadic breast andprostate carcinomas (see TSG16A)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTCF (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTCF (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CTCF (NM_006565) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTCF | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTCF |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTCF |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
CTCF for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CTCF:
Animal Models:
4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ctcf):
CTCF for phenotypes About GeneDecksing
|
Pathways & Interactions
for CTCF gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Meiosis | | | 2 | SIDS Susceptibility Pathways | | | 3 | TGF-beta Receptor Signaling Pathway | | | 4 | Chromatin Regulation / Acetylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CTCF
1 
Cell Signaling Technology (CST) Pathway for CTCF
2  BioSystems Pathways for CTCF
CTCF for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CTCF
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/34 Interacting proteins for CTCF (P497112, 3 ENSP000002640104) via UniProtKB, MINT, STRING, and/or I2D (see all 34)About this table
Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006306 | DNA methylation |
-- | -- | | GO:0006349 | regulation of gene expression by genetic imprinting |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0007059 | chromosome segregation |
IEA | -- |
CTCF for ontologies About GeneDecksing
|
Drugs & Compounds
for CTCF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CTCF for compounds About GeneDecksing
 Browse Tocris compounds for CTCF
4 Novoseek chemical compound relationships for CTCF gene About this table
Search CenterWatch for drugs/clinical trials and news about CTCF
|
Transcripts
for CTCF gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CTCF gene (2 alternative transcripts): NM_001191022.1 NM_006565.3 Unigene Cluster for CTCF: CCCTC-binding factor (zinc finger protein) Hs.368367 [show with all ESTs]Unigene Representative Sequence: NM_0065653 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264010(uc002etl.3) ENST00000401394(uc002etm.1 uc010cek.3)
ENST00000566078
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTCF (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTCF (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CTCF (NM_006565) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CTCF | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTCF |
Additional cDNA sequence: AB209793.1 AK093395.1 AK314804.1 BC014267.2 BT009915.1 U25435.1 11 DOTS entries: DT.417853 DT.100754165 DT.97822115 DT.95090087 DT.92431171 DT.120708965 DT.120708982 DT.91941097 DT.95088550 DT.91897972 DT.95155350 24/215 AceView cDNA sequences (see all 215): BM471463 BM998850 CA396422 AI420206 AI753629 CB241893 BX479165 AU125348 BP351405 H56021 BM981300 BU184110 F03030 CA434958 AU120655 BQ002156 AA478559 BC014267 CA438106 CK904287 N89961 NM_006565 AA478693 AW518901
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for CTCF About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CTCF
|
Expression
for CTCF gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CTCF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGACCTGTAA
About this image
See CTCF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CTCF
SOURCE GeneReport for Unigene cluster: Hs.368367
UniProtKB/Swiss-Prot: CTCF_HUMAN, P49711Tissue specificity: Ubiquitous. Absent in primary spermatocytes
SABiosciences Expression via Pathway-Focused PCR Arrays including CTCF: | Polycomb & Trithorax Complexes in human mouse rat | | Epigenetic Chromatin Remodeling Factors in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTCF
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTCF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTCF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTCF | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTCF |
Orthologs
for CTCF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CTCF gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CTCF1 |
CCCTC-binding factor (zinc finger protein) |
83.88(n)
93.66(a) |
|
396274 NM_205332.4 NP_990663.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CTCF6 |
-- |
92(a) |
1 ↔ 1 |
GL343295.1(966732-978156) |
African clawed frog
(Xenopus laevis) |
Amphibia |
MGC684192 |
hypothetical protein MGC68419 |
79.35(n) |
|
BC057697.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ctcf1 |
CCCTC-binding factor (zinc finger protein) |
72.97(n)
80.39(a) |
|
415104 NM_001001844.1 NP_001001844.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CTCF3 |
transcription factor |
34(a) |
|
65F6 -- |
ENSEMBL Gene Tree for CTCF (if available)
TreeFam Gene Tree for CTCF (if available) |
Paralogs
for CTCF gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CTCF gene
- CTCFL2 HINFP2 ZFP642 ZNF3112
5 SIMAP similar genes for CTCF using alignment to 1 protein entry: CTCF_HUMAN:CTCFL ZNF323 ZNF32 ZNF419 ZNF589
CTCF for paralogs About GeneDecksing
|
Genomic Variants
for CTCF gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CTCF (67596310 - 67673088 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CTCF
1 CNV: 67019 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTCF |
|
Disorders
/ Diseases
for CTCF gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CTCF for disorders About GeneDecksing
OMIM gene information: 604167
OMIM disorders: --
20/35  diseases for CTCF (see all 35): About MalaCardsnorth american indian childhood cirrhosis wilms tumor beckwith-wiedemann syndrome cornelia de lange syndrome
breast cancer prostate cancer silver-russell syndrome congenital mesoblastic nephroma
mesoblastic nephroma prostatitis x inactivation b-cell lymphomas
laryngeal squamous cell carcinoma friedreich ataxia mantle cell lymphoma squamous cell carcinoma
coronary heart disease herpes simplex myeloid leukemia kaposi's sarcoma
3 diseases from the University of Copenhagen DISEASES database for CTCF:Beckwith-Wiedemann syndrome Silver-Russell syndrome Cornelia de Lange syndrome 10/18 Novoseek disease relationships for CTCF gene (see all 18) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| beckwith-wiedemann syndrome |
67.3 |
2 |
17158821 (1), 15743916 (1) |
| wilms tumor |
42.1 |
5 |
15743916 (2), 11431321 (1), 12203779 (1), 11782357 (1) |
| carcinoma lobular |
31.5 |
2 |
18213475 (1), 15609312 (1) |
| breast cancer |
25.4 |
23 |
15958555 (6), 15084242 (3), 15354217 (2), 14503807 (2) (see all 11) |
| growth retardation |
24.9 |
2 |
15941718 (1), 11507042 (1) |
| cancer |
20.1 |
15 |
12191639 (2), 18095639 (1), 20101205 (1), 18625744 (1) (see all 11) |
| tumors |
15.5 |
44 |
9591631 (3), 10545425 (2), 15958555 (2), 19450526 (2) (see all 22) |
| hnscc |
15.3 |
2 |
16391843 (2) |
| myeloid leukemia |
8.49 |
3 |
15941718 (2), 10037138 (1) |
| breast carcinoma |
3.66 |
1 |
15354217 (1) |
Genetic Association Database (GAD): CTCF
Human Genome Epidemiology (HuGE) Navigator: CTCF (8 documents)
Export disorders for CTCF gene to outside databases
|
Publications
for CTCF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CTCF gene, integrated from 9 sources (see all 261):
(articles sorted by number of sources associating them with CTCF) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. (PubMed id 8649389)1, 2, 3, 9 Filippova G.N.... Lobanenkov V.V. (1996)
- CTCF physically links cohesin to chromatin. (PubMed id 18550811)1, 2, 3, 9 Rubio E.D.... Krumm A. (2008)
- A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers. (PubMed id 9591631)1, 2, 9 Filippova G.N.... Lobanenkov V.V. (1998)
- CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. (PubMed id 16815976)1, 2, 9 Kurukuti S.... Ohlsson R. (2006)
- Critical DNA binding interactions of the insulator protein CTCF: a small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci. (PubMed id 17827499)1, 2, 9 Renda M....Pedone P.V. (2007)
- Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter its DNA-binding specificity. (PubMed id 11782357)1, 2, 9 Filippova G.N.... Lobanenkov V.V. (2002)
- The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. (PubMed id 12191639)1, 2, 9 Klenova E.M.... Lobanenkov V.V. (2002)
- A screen for germline mutations in the gene encoding CCCTC-binding factor (CTCF) in familial non-BRCA1/BRCA2 breast cancer. (PubMed id 15084242)1, 4, 9 Zhou X.L....Lindblom A. (2004)
- CTCF, a candidate trans-acting factor for X-inactivation choice. (PubMed id 11743158)1, 2, 9 Chao W.... Lee J.T. (2002)
- Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster. (PubMed id 19322193)1, 2, 9 Mishiro T.... Nakao M. (2009)
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External Searches for CTCF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CTCF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CTCF gene
(According to HUGE)
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Specialized Databases showing CTCF gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for CTCF gene:
Search GeneIP for patents involving CTCF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CTCF gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for CTCF | | OriGene shRNA RFP for CTCF | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTCF | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTCF | | | OriGene Protein Over-expression Lysate for CTCF | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CTCF | | OriGene 3'-UTR Clone for CTCF | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTCF | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTCF | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CTCF | | OriGene Custom Protein Services for CTCF | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CTCF | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTCF | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTCF | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTCF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTCF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTCF |
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| | Antibodies & Assays for CTCF |
| | | | Search Tocris compounds for CTCF |
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 | | | CTCF Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTCF |
|  |  |  | | | | ThermoFisher Antibodies for CTCF |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTCF |
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