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Aliases for CTBS Gene

Aliases for CTBS Gene

  • Chitobiase, Di-N-Acetyl- 2 3
  • CTB 3 4 6
  • Di-N-Acetylchitobiase 3
  • EC 3.2.1.- 4

External Ids for CTBS Gene

Previous HGNC Symbols for CTBS Gene

  • CTB

Previous GeneCards Identifiers for CTBS Gene

  • GC01P085516
  • GC01M084156
  • GC01M084307
  • GC01M084442
  • GC01M084732
  • GC01M085018
  • GC01M083128

Summaries for CTBS Gene

Entrez Gene Summary for CTBS Gene

  • Chitobiase is a lysosomal glycosidase involved in degradation of asparagine-linked oligosaccharides on glycoproteins (Aronson and Kuranda, 1989 [PubMed 2531691]).[supplied by OMIM, Nov 2010]

GeneCards Summary for CTBS Gene

CTBS (Chitobiase, Di-N-Acetyl-) is a Protein Coding gene. GO annotations related to this gene include chitinase activity.

UniProtKB/Swiss-Prot for CTBS Gene

  • Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase

Gene Wiki entry for CTBS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTBS Gene

Genomics for CTBS Gene

Regulatory Elements for CTBS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTBS Gene

84,549,606 bp from pter
84,574,480 bp from pter
24,875 bases
Minus strand

Genomic View for CTBS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTBS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTBS Gene

Proteins for CTBS Gene

  • Protein details for CTBS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5VX50

    Protein attributes for CTBS Gene

    385 amino acids
    Molecular mass:
    43760 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CTBS Gene

Proteomics data for CTBS Gene at MOPED

Post-translational modifications for CTBS Gene

  • Glycosylation at Asn193, Asn228, Asn262, and Asn299
  • Modification sites at PhosphoSitePlus

Other Protein References for CTBS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CTBS Gene

Domains for CTBS Gene

Suggested Antigen Peptide Sequences for CTBS Gene

Graphical View of Domain Structure for InterPro Entry



  • Q01459
  • Belongs to the glycosyl hydrolase 18 family.
genes like me logo Genes that share domains with CTBS: view

No data available for Gene Families for CTBS Gene

Function for CTBS Gene

Molecular function for CTBS Gene

GENATLAS Biochemistry: lysosomal chitobiase,involved in degradation of asparagine-linked glycoproteins
UniProtKB/Swiss-Prot Function: Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase

Enzyme Numbers (IUBMB) for CTBS Gene

Gene Ontology (GO) - Molecular Function for CTBS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds --
GO:0004568 chitinase activity IBA --
GO:0008061 chitin binding IBA --
genes like me logo Genes that share ontologies with CTBS: view
genes like me logo Genes that share phenotypes with CTBS: view

Animal Models for CTBS Gene

MGI Knock Outs for CTBS:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for CTBS Gene

Localization for CTBS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTBS Gene


Subcellular locations from

Jensen Localization Image for CTBS Gene COMPARTMENTS Subcellular localization image for CTBS gene
Compartment Confidence
lysosome 5
vacuole 5
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CTBS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005764 lysosome IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CTBS: view

Pathways for CTBS Gene

SuperPathways for CTBS Gene

No Data Available

Interacting Proteins for CTBS Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000359664 Q01459-DIAC_HUMAN for CTBS Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CTBS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006032 chitin catabolic process IBA --
GO:0009313 oligosaccharide catabolic process IEA --
genes like me logo Genes that share ontologies with CTBS: view

No data available for Pathways by source for CTBS Gene

Compounds for CTBS Gene

(2) HMDB Compounds for CTBS Gene

Compound Synonyms Cas Number PubMed IDs
  • 4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxa
  • 2-Amino-2-deoxy-D-glucopyranose
genes like me logo Genes that share compounds with CTBS: view

Transcripts for CTBS Gene

Unigene Clusters for CTBS Gene

Chitobiase, di-N-acetyl-:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTBS

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CTBS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTBS Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP3: - -
SP4: -

Relevant External Links for CTBS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CTBS Gene

mRNA expression in normal human tissues for CTBS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CTBS Gene

This gene is overexpressed in Whole Blood (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CTBS Gene

SOURCE GeneReport for Unigene cluster for CTBS Gene Hs.513557

genes like me logo Genes that share expressions with CTBS: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CTBS Gene

Orthologs for CTBS Gene

This gene was present in the common ancestor of chordates.

Orthologs for CTBS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CTBS 35
  • 98.43 (n)
  • 97.91 (a)
  • 98 (a)
(Bos Taurus)
Mammalia CTB 36
  • 71 (a)
  • 84.21 (n)
  • 74.27 (a)
(Canis familiaris)
Mammalia CTBS 35
  • 84.52 (n)
  • 77.04 (a)
  • 77 (a)
(Mus musculus)
Mammalia Ctbs 35
  • 86.97 (n)
  • 87.2 (a)
Ctbs 16
Ctbs 36
  • 83 (a)
(Monodelphis domestica)
Mammalia CTBS 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia CTBS 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Ctbs 35
  • 82.8 (n)
  • 82.8 (a)
(Gallus gallus)
Aves CTBS 35
  • 74.22 (n)
  • 75.29 (a)
  • 69 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 62 (a)
-- 36
  • 66 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64330 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ctbs 35
  • 67.85 (n)
  • 67.46 (a)
Str.703 35
(Danio rerio)
Actinopterygii ctbs 35
  • 66.96 (n)
  • 70 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for CTBS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTBS Gene

Gene Tree for CTBS (if available)
Gene Tree for CTBS (if available)

Paralogs for CTBS Gene

No data available for Paralogs for CTBS Gene

Variants for CTBS Gene

Sequence variations from dbSNP and Humsavar for CTBS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15911 - 84,563,394(+) AGGGA(C/T)TTTTG missense, reference
rs1891126 -- 84,570,855(-) TGGGA(A/C)CCCTA intron-variant
rs2303306 -- 84,570,556(+) TGCTG(C/G)ACACA intron-variant
rs2303307 -- 84,574,272(+) CGGCA(A/G)AGCTC reference, synonymous-codon
rs2911584 -- 84,564,676(+) GTCTT(G/T)CCTGA intron-variant

Relevant External Links for CTBS Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CTBS Gene

Disorders for CTBS Gene

No disorders were found for CTBS Gene.

No data available for UniProtKB/Swiss-Prot for CTBS Gene

Publications for CTBS Gene

  1. Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22. (PMID: 7606925) Ahmad W. … Aronson N.N. (Cytogenet. Cell Genet. 1995) 2 3 23
  2. Cloning and expression of the cDNA sequence encoding the lysosomal glycosidase di-N-acetylchitobiase. (PMID: 1527079) Fisher K.J. … Aronson N.N. Jr. (J. Biol. Chem. 1992) 3 4
  3. Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5). (PMID: 1549114) Fisher K.J. … Aronson N.N. (Mol. Cell. Biol. 1992) 2 3
  4. Structure of the human gene for lysosomal di-N-acetylchitobiase. (PMID: 10336991) Liu B. … Aronson N.N. Jr. (Glycobiology 1999) 3 4
  5. N-acetyl beta-D-glucosaminidase is not attached to human sperm membranes through the glycosylphosphatidyl inositol (GPI)-anchor. (PMID: 11907625) Hutchinson T. … Pereira B.M. (Asian J. Androl. 2002) 3

Products for CTBS Gene

Sources for CTBS Gene

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