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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CTBS Gene

protein-coding   GIFtS: 52
GCID: GC01M085018

chitobiase, di-N-acetyl-


(Previous symbol: CTB)
 Explore 3 diseases affiliated with
CTBS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CTBS    

Aliases
for CTBS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chitobiase, Di-N-Acetyl-1 2
CTB1 2 3 5
Di-N-Acetylchitobiase1
EC 3.2.1.-3

External Ids:    HGNC: 24961   Entrez Gene: 14862   Ensembl: ENSG000001171517   OMIM: 6008735   UniProtKB: Q014593   

Export aliases for CTBS gene to outside databases

Previous GC identifers: GC01P085516 GC01M084156 GC01M084307 GC01M084442 GC01M084732 GC01M083128


Summaries
for CTBS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CTBS:
Chitobiase is a lysosomal glycosidase involved in degradation of asparagine-linked oligosaccharides on glycoproteins
(Aronson and Kuranda, 1989 (PubMed 2531691)).(supplied by OMIM, Nov 2010)

UniProtKB/Swiss-Prot: DIAC_HUMAN, Q01459
Function: Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine
(1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by
glycosylasparaginase

Gene Wiki entry for CTBS


Genomic Views
for CTBS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CTBS gene promoter:
         ER-alpha   LHX3b/Lhx3b   p300   AP-4   LUN-1   Evi-1   PPAR-alpha   LHX3a/Lhx3a   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CTBS promoter sequence
   Search SABiosciences Chromatin IP Primers for CTBS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CTBS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22

CTBS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CTBS gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M085018:  view genomic region     (about GC identifiers)

Start:
 85,018,804 bp from pter      End:
 85,040,163 bp from pter
Size:
 21,360 bases      Orientation:
 minus strand

Proteins
for CTBS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DIAC_HUMAN, Q01459 (See protein sequence)
Recommended Name: Di-N-acetylchitobiase precursor  
Size: 385 amino acids; 43760 Da
Subcellular location: Lysosome
Secondary accessions: Q5VX50

Explore the universe of human proteins at neXtProt for CTBS: NX_Q01459

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01459

    • CTBS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004379.1  
    ENSEMBL proteins: 
     ENSP00000359664   ENSP00000452177   ENSP00000359659  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CTBS
    OriGene Protein Over-expression Lysate: CTBS
    OriGene Custom Protein Services for CTBS 
    GenScript Custom Purified and Recombinant Proteins Services for CTBS
    Novus Biologicals CTBS Protein
    Novus Biologicals CTBS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CTBS

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005764lysosome IEA--


    CTBS for ontologies           About GeneDecksing



    CTBS Antibody Products: 
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    Uscn ELISAs and CLIAs for CTBS

    Protein Domains /
    Families
    for CTBS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CTBS for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011583 Chitinase_II
     IPR017853 Glycoside_hydrolase_SF
     IPR001223 Glyco_hydro18cat
     IPR013781 Glyco_hydro_catalytic_dom
     IPR001579 Glyco_hydro_18_chit_AS

    Graphical View of Domain Structure for InterPro Entry Q01459

    ProtoNet protein and cluster: Q01459

    1 Blocks protein family: IPB001579 Glycoside hydrolase

    UniProtKB/Swiss-Prot: DIAC_HUMAN, Q01459
    Similarity: Belongs to the glycosyl hydrolase 18 family


    Function
    for CTBS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DIAC_HUMAN, Q01459
    Function: Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine
    (1-4)N-acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by
    glycosylasparaginase

         Genatlas biochemistry entry for CTBS:
    lysosomal chitobiase,involved in degradation of asparagine-linked glycoproteins

    Enzyme Number (IUBMB): EC 3.2.1.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone: CTBS
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTBS
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CTBS:
    hsa-miR-3163 hsa-miR-4307 hsa-miR-607 hsa-miR-4282 hsa-miR-582-5p hsa-miR-567 hsa-miR-3658 hsa-miR-331-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CTBS 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTBS (see all 7)
    OriGene shRNA RFP: CTBS
    OriGene siRNA: CTBS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTBS

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CTBS

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTBS (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTBS
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CTBS (NM_004388)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTBS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTBS 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CTBS
    Search LifeMap BioReagents cell lines for CTBS

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTBS

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004568chitinase activity IEA--
    GO:0043169cation binding IEA--


    CTBS for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CTBS:
     Decreased Hepatitis C virus re 

    Animal Models:
         Mouse knock-out Ctbstm1Tbec for CTBS
         7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ctbs):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  renal/urinary system 

    CTBS for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CTBS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CTBS

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CTBS (Q014593 ENSP000003596644) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNBP1Q96RU33, ENSP000004136254I2D: score=1 STRING: ENSP00000413625
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006032chitin catabolic process IEA--
    GO:0009313oligosaccharide catabolic process IEA--


    CTBS for ontologies           About GeneDecksing



    Drugs & Compounds
    for CTBS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CTBS

    2 HMDB Compounds for CTBS    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Glucosaminide4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxa (see all 2)78341-33-0--
    Glucosamine2-Amino-2-deoxy-D-glucopyranose (see all 10)3416-24-8--
    Search CenterWatch for drugs/clinical trials and news about CTBS / DIAC 

    Transcripts
    for CTBS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CTBS gene: 
    NM_004388.2  

    Unigene Cluster for CTBS:

    Chitobiase, di-N-acetyl-
    Hs.513557  [show with all ESTs]
    Unigene Representative Sequence: NM_004388
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477677(uc001dkb.2) ENST00000370630(uc001dkc.3 uc001dka.2)
    ENST00000465118 ENST00000370625

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CTBS
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CTBS
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CTBS:
    hsa-miR-3163 hsa-miR-4307 hsa-miR-607 hsa-miR-4282 hsa-miR-582-5p hsa-miR-567 hsa-miR-3658 hsa-miR-331-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CTBS 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CTBS (see all 7)
    OriGene shRNA RFP: CTBS
    OriGene siRNA: CTBS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CTBS
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CTBS (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CTBS
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CTBS (NM_004388)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CTBS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CTBS 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CTBS
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CTBS
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CTBS
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CTBS

    Additional cDNA sequence: 

    AK075423.1 AK298703.1 AK314640.1 BC024007.2 BC065191.1 BC096752.1 BC126333.1 BC126335.1 
    M95767.1 

    8 DOTS entries:

    DT.95172057  DT.410826  DT.95297552  DT.92443352  DT.121427673  DT.100782215  DT.121427721  DT.97795709 

    24/423 AceView cDNA sequences (see all 423):

    BF589956 AI360028 AI803051 BG008942 AI346848 CB133657 AI927528 AI911433 
    F36740 BF109470 CK818850 CB121330 AI922298 AI626058 BX956979 BQ232618 
    CR590327 BM784623 AW340694 BM922137 CD108724 CB241216 BT006823 H15938 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CTBS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
    SP1:        -                                                   
    SP2:                                                            
    SP3:        -           -                                       
    SP4:                    -                                       


    ECgene alternative splicing isoforms for CTBS

    Expression
    for CTBS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CTBS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAGTGGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CTBS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CTBS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CTBS

    SOURCE GeneReport for Unigene cluster: Hs.513557
        SABiosciences Custom PCR Arrays for CTBS
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CTBS

    Orthologs
    for CTBS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CTBS gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ctbs1 , 5 chitobiase, di-N-acetyl-1, 5 86.58(n)1
    86.04(a)1    		   3 (71.26 cM)5
    742451  NM_028836.31  NP_083112.11 
     1464504705 
    chicken
    (Gallus gallus)    		 Aves CTBS1 chitobiase, di-N-acetyl- 72.73(n)
    73(a)    		   424535  XM_422372.3  XP_422372.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CTBS6
    		 --
    		 67(a)
    		 1 ↔ 1
    		 GL343194.1(9678186-9686703)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC643302 hypothetical protein MGC64330 75.88(n)    BC041322.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ctbs1 chitobiase, di-N-acetyl- 66.96(n)
    70(a)    		   553763  NM_001020729.1  NP_001018565.1 


    ENSEMBL Gene Tree for CTBS (if available)
    TreeFam Gene Tree for CTBS (if available) 

    Paralogs
    for CTBS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CTBS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/394 NCBI SNPs in CTBS are shown (see all 394)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs604193061,2
    		C,F,--83128406(+) AAGGGT/GTTTTT 1 -- int14Minor allele frequency- G:0.33WA CSA 123
    rs170991631,2
    		C,F,H,--83128708(+) GTTTAC/TATGAC 1 -- int121Minor allele frequency- T:0.13NA NS EA WA CSA 2242
    rs120683401,2
    		F,H,--83129340(+) TATGAT/CAGAGA 1 -- ds50014Minor allele frequency- C:0.01NS EA 420
    rs1867963521,2
    		--85018321(+) ATTCCA/GTTCCT 2 -- int10--------
    rs1395992871,2
    		--85018495(+) TAAACA/GAGGTT 2 -- int10--------
    rs1443331401,2
    		--85018627(+) TAAAGC/TGGTTA 2 -- int10--------
    rs1930145611,2
    		--85019145(+) TAAATA/GTATAT 2 -- ut31 ds50010--------
    rs1418133151,2
    		--85019216(+) ATATC-/TTAA  
                TTAAA     		2 -- ut31 ds50010--------
    rs1510002021,2
    		--85019424(+) CATAAC/TAGATG 1 -- ut310--------
    rs1171152561,2
    		F,--85019549(+) GGGCAG/ACACAA 1 -- ut311Minor allele frequency- A:0.02EA 120

    HapMap Linkage Disequilibrium report for CTBS (85018804 - 85040163 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CTBS: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CTBS
    DNA2.0 Custom Variant and Variant Library Synthesis for CTBS

    Disorders / Diseases
    for CTBS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CTBS for disorders           About GeneDecksing

    OMIM gene information: 600873    OMIM disorders: --

    3 diseases for CTBS:    About MalaCards
    pre-eclampsia    spontaneous abortion    eclampsia


    Export disorders for CTBS gene to outside databases

    Publications
    for CTBS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CTBS gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CTBS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22. (PubMed id 7606925)1, 3, 9 Ahmad W....Aronson N.N. (1995)
    2. Structure of the human gene for lysosomal di-N-acetylchitobiase. (PubMed id 10336991)1, 2 Liu B.... Aronson N.N. Jr. (1999)
    3. Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5). (PubMed id 1549114)1, 3 Fisher K.J. and Aronson N.N. (1992)
    4. Cloning and expression of the cDNA sequence encoding the lysosomal glycosidase di-N-acetylchitobiase. (PubMed id 1527079)1, 2 Fisher K.J. and Aronson N.N. Jr. (1992)
    5. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    7. Optimum substrate size and specific anomer requirements for the reducing-end glycoside hydrolase di-N-acetylchitobiase. (PubMed id 16794344)1 Aronson N.N. and Halloran B.A. (2006)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    9. A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. (PubMed id 15252009)1 Kamioka Y....Mochizuki N. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for CTBS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CTBS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1486 HGNC: 2496 AceView: CTBSandGNG5 Ensembl:ENSG00000117151 euGenes: HUgn1486
    ECgene: CTBS H-InvDB: CTBS

    Other Databases showing CTBS gene

    (According to HUGE)
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    Specialized Databases showing CTBS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CTBS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    		Patent Information for CTBS gene:
    Search GeneIP for patents involving CTBS

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